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</div><div><span>Alpha-1 antitrypsin blood test</span></div></div>
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<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also" itemprop="name">Alpha-1 antitrypsin blood test</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Alpha-1 antitrypsin (AAT) is a laboratory test to measure the amount of AAT in your blood. The test is also done to check for abnormal forms of AAT.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>A blood sample is needed.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How to Prepare for the Test</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-2"><p>There is no special preparation.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test will Feel</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Why the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>This test is helpful in identifying a rare form of emphysema in adults and a rare form of liver disease (cirrhosis) in children and adults caused by an <a test="test" href="./000120.htm">AAT deficiency</a>. AAT deficiency is passed down through families. The condition causes the liver to make too little of AAT, a protein that protects the lungs and liver from damage.</p><p>Everyone has two copies of the gene that makes AAT. People with two abnormal copies of the gene have more severe disease and lower blood levels.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Normal Results</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Normal value ranges may vary slightly among different laboratories. Talk to your health care provider about the meaning of your specific test results.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>What Abnormal Results Mean</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>A lower-than-normal level of AAT may be associated with:</p><ul><li>
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Damage of the large airways in the lungs (<a test="test" href="./000144.htm">bronchiectasis</a>)</li><li>
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Scarring of the liver (<a test="test" href="./000255.htm">cirrhosis</a>)</li><li><a test="test" href="./000091.htm">Chronic obstructive pulmonary disease</a> (COPD)</li><li><a test="test" href="./000280.htm">Liver tumors</a></li><li>
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Yellowing of the skin and eyes due to blocked bile flow (<a test="test" href="./000210.htm">obstructive jaundice</a>)</li><li>High blood pressure in the large vein that leads to the liver (portal hypertension)</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Risks</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another, and from one side of the body to the other. Taking blood from some people may be more difficult than from others.</p><p>Other risks associated with having blood drawn are slight, but may include:</p><ul><li>Fainting or feeling lightheaded</li><li>Multiple punctures to locate veins</li><li>Hematoma (blood accumulating under the skin)</li><li>Infection (a slight risk anytime the skin is broken) </li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>A1AT test</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Chernecky CC, Berger BJ. Alpha<sub>1</sub>-antitrypsin - serum. In: Chernecky CC, Berger BJ, eds. <em>Laboratory Tests and Diagnostic Procedures</em>. 6th ed. St Louis, MO: Elsevier Saunders; 2013:121-122.</p><p>Winnie GB, Boas SR. a<sub>1 </sub>- Antitrypsin deficiency and emphysema. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. <em>Nelson Textbook of Pediatrics</em>. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 421. </p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 7/31/2022</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Denis Hadjiliadis, MD, MHS, Paul F. Harron, Jr. Professor of Medicine, Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.</p>
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</div></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Related MedlinePlus Health Topics</h2></div><div class="section-button"><button type="submit" aria-controls="section-mtp" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div name="Related MedlinePlus Health Topics" class="section-body" id="section-mtp"><ul class="side-nav"><li><a href="https://medlineplus.gov/alpha1antitrypsindeficiency.html">Alpha-1 Antitrypsin Deficiency</a></li>
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<li><a href="https://medlineplus.gov/cirrhosis.html">Cirrhosis</a></li>
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<li><a href="https://medlineplus.gov/emphysema.html">Emphysema</a></li>
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