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</div><div><span>Creatinine clearance test</span></div></div>
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</noscript></div><div class="main"><div id="ency_summary"><p>The creatinine clearance test helps provide information about how well the kidneys are working. The test compares the creatinine level in urine with the creatinine level in blood. </p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>This test requires both a <a test="test" href="./003610.htm">urine sample</a> and <a test="test" href="./003475.htm">blood sample</a>. You will <a test="test" href="./003425.htm">collect your urine for 24 hours</a> and then have blood taken. Follow instructions exactly. This ensures accurate results.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How to Prepare for the Test</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Before the test, your health care provider may ask you to stop taking medicines that may affect the test results. These include some antibiotics and stomach acid medicines. Be sure to tell your provider about all the medicines you take. </p><p>Do not stop taking any medicine before talking to your provider.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test will Feel</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>The urine test involves only normal urination. There is no discomfort.</p><p>When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Why the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>Creatinine is a waste product of creatine. Creatine is a chemical the body makes to supply energy, mainly to muscles.</p><p>The creatinine clearance test compares the <a test="test" href="./003610.htm">creatinine level in urine</a> with the <a test="test" href="./003475.htm">creatinine level in blood</a>. This gives an estimate of the <a test="test" href="./007305.htm">glomerular filtration rate</a> (GFR). GFR is a measure of how well the kidneys are working, mainly the kidneys' filtering units. These filtering units are called glomeruli.</p><p>Creatinine is removed, or cleared, from the body by the kidneys. If kidney function is abnormal, creatinine level increases in the blood because less creatinine is excreted through the urine. </p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Normal Results</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Clearance is often measured as milliliters per minute (mL/min) or milliliters per second (mL/s). Normal values are:</p><ul><li>Male: 97 to 137 mL/min (1.65 to 2.33 mL/s).</li><li>Female: 88 to 128 mL/min (1.467 to 2.18 mL/s). </li></ul><p>Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider to know about the meaning of your specific test results. </p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>What Abnormal Results Mean</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>A lower than normal creatinine clearance may indicate:</p><ul><li>
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Kidney problems, such as <a test="test" href="./000512.htm">damage to the tubule cells</a></li><li><a test="test" href="./000501.htm">Kidney failure</a></li><li>Too little blood flow to the kidneys</li><li><a test="test" href="./000484.htm">Damage to the filtering units of the kidneys</a> (glomerulonephritis)</li><li><a test="test" href="./000982.htm">Loss of body fluids</a> (dehydration)</li><li>Bladder outlet obstruction</li><li><a test="test" href="./000158.htm">Heart failure</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Risks</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.</p><p>Other risks associated with having blood drawn are slight, but may include:</p><ul><li>Excessive bleeding</li><li>Fainting or feeling lightheaded</li><li>Multiple punctures to locate veins</li><li>Blood accumulating under the skin (hematoma)</li><li>Infection (a slight risk any time the skin is broken) </li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Serum creatinine clearance; Kidney function - creatinine clearance; Renal function - creatinine clearance</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/9229t.jpg" alt="Creatinine tests" title="Creatinine tests" class="side-img"/><a href="../imagepages/9229.htm">Creatinine tests</a></li>
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Gharavi AG, Landry DW. Approach to the patient with renal disease. In: Goldman L, Cooney KA, eds. <em>Goldman-Cecil Medicine</em>. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 100.</p><p>Oh MS, Briefel G, Pincus MR. Evaluation of renal function, water, electrolytes, and acid-base balance. In: McPherson RA, Pincus MR, eds. <em>Henry's Clinical Diagnosis and Management by Laboratory Methods</em>. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 15.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 8/20/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Jacob Berman, MD, MPH, Clinical Assistant Professor of Medicine, Division of General Internal Medicine, University of Washington School of Medicine, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. Editorial update: 02/07/2024.</p>
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