nih-gov/medlineplus.gov/ency/article/003501.htm
2025-02-26 13:17:41 -05:00

295 lines
No EOL
30 KiB
HTML
Raw Blame History

This file contains ambiguous Unicode characters

This file contains Unicode characters that might be confused with other characters. If you think that this is intentional, you can safely ignore this warning. Use the Escape button to reveal them.

<!DOCTYPE html>
<html lang="en" id="article" class="nojs us" data-root="//medlineplus.gov" itemid="https://medlineplus.gov/ency/article/003501.htm" itemtype="http://schema.org/MedicalWebPage" itemscope="">
<head>
<meta http-equiv="X-UA-Compatible" content="IE=edge,chrome=1"/>
<meta http-equiv="window-target" content="_top"/>
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8"/>
<meta charset="utf-8"/>
<meta property="fb:app_id" content="1042245625821448"/>
<meta name="expires" content="Wed, 05 02 2025"/>
<meta name="ac-dictionary" content="medlineplus-ac-dictionary"/>
<link rel="shortcut icon" href="https://medlineplus.gov/images/favicon.ico" type="image/x-icon"/>
<link rel="apple-touch-icon" href="//medlineplus.gov/images/touch-icon.png"/>
<meta name="viewport" content="width=device-width, initial-scale=1"/>
<link rel="stylesheet" href="https://medlineplus.gov/css/common_new.css?04272023"/>
<!--[if IE 8]> <link rel="stylesheet" href="https://medlineplus.gov/css/ie8/common.css"><![endif]-->
<link rel="stylesheet" href="https://medlineplus.gov/uswds/css/uswds_styles.css"/>
<link rel="stylesheet" href="https://medlineplus.gov/css/ency/ency2.css?07162024"/>
<script type="text/javascript">document.querySelector("html").className = document.querySelector("html").className.replace(/nojs[\s]*/g, '');</script>
<script src="https://medlineplus.gov/uswds/js/uswds-init.min.js" type="text/javascript">
</script>
<script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&amp;l='+l:'';j.async=true;j.src='//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-MMVM77');</script>
<link rel="canonical" href="https://medlineplus.gov/ency/article/003501.htm" itemprop="url"/>
<link rel="alternative" hreflang="es" href="https://medlineplus.gov/spanish/ency/article/003501.htm"/>
<link rel="alternative" hreflang="en" href="https://medlineplus.gov/ency/article/003501.htm"/><meta property="og:title" content="Schirmer test: MedlinePlus Medical Encyclopedia"/><meta property="og:url" content="https://medlineplus.gov/ency/article/003501.htm"/><meta property="twitter:title" content="Schirmer test: MedlinePlus Medical Encyclopedia"/><meta name="twitter:card" content="summary_large_image"/><meta name="description" content="The Schirmer test determines whether the eye produces enough tears to keep it moist."/><meta itemprop="description" name="description" content="The Schirmer test determines whether the eye produces enough tears to keep it moist."/><meta property="og:description" content="The Schirmer test determines whether the eye produces enough tears to keep it moist."/><meta property="twitter:description" content="The Schirmer test determines whether the eye produces enough tears to keep it moist."/><meta property="og:image" content="https://medlineplus.gov/images/share_ency_1.jpg"/><meta property="og:image" content="https://medlineplus.gov/images/share_ency_2.jpg"/><meta property="og:image" content="https://medlineplus.gov/images/share_ency_3.jpg"/><meta property="twitter:image" content="https://medlineplus.gov/images/share_ency_1.jpg"/>
<title>Schirmer test: MedlinePlus Medical Encyclopedia</title>
</head>
<body><link href="http://schema.org/Patient" itemprop="audience"/>
<!-- Google Tag Manager -->
<noscript><iframe title="googletagmanager" src="//www.googletagmanager.com/ns.html?id=GTM-MMVM77" height="0" width="0" style="display:none;visibility:hidden">
</iframe>
</noscript>
<!-- End Google Tag Manager -->
<a name="top" id="top">
</a>
<a class="hide-offscreen" href="#start">Skip navigation</a>
<section class="usa-banner" aria-label="Official website of the United States government">
<div class="usa-accordion">
<header class="usa-banner__header">
<div class="usa-banner__inner">
<div class="grid-col-auto">
<img aria-hidden="true" class="usa-banner__header-flag" src="https://medlineplus.gov/uswds/img/us_flag_small.png" alt=""/>
</div>
<div class="grid-col-fill tablet:grid-col-auto" aria-hidden="true">
<p class="usa-banner__header-text">
An official website of the United States government
</p>
<p class="usa-banner__header-action">Heres how you know</p>
</div>
<button type="button" class="usa-accordion__button usa-banner__button" aria-expanded="false" aria-controls="gov-banner-default-default">
<span class="usa-banner__button-text">Heres how you know</span>
</button>
</div>
</header>
<div class="usa-banner__content usa-accordion__content" id="gov-banner-default-default">
<div class="grid-row grid-gap-lg">
<div class="usa-banner__guidance tablet:grid-col-6">
<img class="usa-banner__icon usa-media-block__img" src="https://medlineplus.gov/uswds/img/icon-dot-gov.svg" role="img" alt="" aria-hidden="true"/>
<div class="usa-media-block__body">
<p>
<strong>Official websites use .gov</strong><br/>A
<strong>.gov</strong> website belongs to an official government
organization in the United States.
</p>
</div>
</div>
<div class="usa-banner__guidance tablet:grid-col-6">
<img class="usa-banner__icon usa-media-block__img" src="https://medlineplus.gov/uswds/img/icon-https.svg" role="img" alt="" aria-hidden="true"/>
<div class="usa-media-block__body">
<p>
<strong>Secure .gov websites use HTTPS</strong><br/>A
<strong>lock</strong> (
<span class="icon-lock"><svg xmlns="http://www.w3.org/2000/svg" width="52" height="64" viewBox="0 0 52 64" class="usa-banner__lock-image" role="img" aria-labelledby="banner-lock-description-default" focusable="false">
<title id="banner-lock-title-default">Lock</title>
<desc id="banner-lock-description-default">Locked padlock icon</desc>
<path fill="#000000" fill-rule="evenodd" d="M26 0c10.493 0 19 8.507 19 19v9h3a4 4 0 0 1 4 4v28a4 4 0 0 1-4 4H4a4 4 0 0 1-4-4V32a4 4 0 0 1 4-4h3v-9C7 8.507 15.507 0 26 0zm0 8c-5.979 0-10.843 4.77-10.996 10.712L15 19v9h22v-9c0-6.075-4.925-11-11-11z">
</path>
</svg> </span>) or <strong>https://</strong> means youve safely connected to
the .gov website. Share sensitive information only on official,
secure websites.
</p>
</div>
</div>
</div>
</div>
</div>
</section>
<div id="mplus-wrap">
<header>
<div id="mplus-header">
<!-- Orgs
================================================== -->
<div id="mplus-orgs">
<a title="National Institutes of Health" target="_blank" class="nih-org" href="//www.nih.gov/">
<img alt="National Institutes of Health" src="https://medlineplus.gov/images/nihlogo.png" class="nihlogo"/>
</a><a target="_blank" href="https://www.nlm.nih.gov/"> National Library of Medicine </a>
</div>
<!-- Logo
================================================== -->
<div id="mplus-logo" class="years-25">
<a href="https://medlineplus.gov">
<img src="https://medlineplus.gov/images/m_logo_25.png" title="MedlinePlus Trusted Health Information for You" alt="MedlinePlus Trusted Health Information for You"/>
</a>
</div>
<!-- Nav Menu
================================================== -->
<div id="mplus-nav">
<div class="sm-live-area hide-offscreen" aria-live="polite">The navigation menu has been collapsed.</div>
<!-- Menu Button-->
<button type="submit" aria-controls="mplus-menu-list" role="button" title="Menu" class="navmenu-btn" id="sm-menu-btn" aria-pressed="false" tabindex="0">Menu<span class="icon icon-nav-menu">
</span></button><ul class="nav-list" id="mplus-menu-list">
<li><a href="https://medlineplus.gov/healthtopics.html">Health Topics</a></li>
<li><a href="https://medlineplus.gov/druginformation.html">Drugs &amp; Supplements</a></li>
<li><a href="https://medlineplus.gov/genetics/">Genetics</a></li>
<li><a href="https://medlineplus.gov/lab-tests/">Medical Tests</a></li>
<li><a href="https://medlineplus.gov/encyclopedia.html">Medical Encyclopedia</a></li>
<li><a href="https://medlineplus.gov/about/">About MedlinePlus</a></li>
</ul><button type="submit" aria-controls="mplus-search" role="button" title="Search" class="navmenu-btn" id="sm-search-btn" aria-pressed="false" tabindex="0"><span class="hide-offscreen">Show </span>Search<span class="icon icon-nav-search">
</span></button>
<div class="top-1">
<!-- Search
================================================== -->
<form target="_self" title="Search MedlinePlus" action="//vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta" method="get" id="mplus-search">
<input type="hidden" value="medlineplus" name="v:project"/>
<input type="hidden" value="medlineplus-bundle" name="v:sources"/>
<div class="form-box text-combo">
<div class="form-area"><label for="searchtext_primary" class="hide-offscreen">Search MedlinePlus</label>
<span role="status" aria-live="polite" class="ui-helper-hidden-accessible">
</span><input type="text" aria-haspopup="true" aria-autocomplete="list" role="textbox" autocomplete="off" name="query" size="40" maxlength="400" title="Site Search input" alt="Site Search input" placeholder="Search MedlinePlus" class="form-text ui-autocomplete-input" id="searchtext_primary"/>
</div>
<div class="button-area">
<button type="submit" alt="Search MedlinePlus" title="Search MedlinePlus" class="form-btn">GO</button>
</div>
</div>
</form>
<!-- Secondary Nav
================================================== -->
<div class="secondarynav">
<ul class="nav-list">
<li><a href="https://medlineplus.gov/about/"><span>About MedlinePlus</span></a></li>
<li><a href="https://medlineplus.gov/whatsnew/"><span>What's New</span></a></li>
<li><a href="https://medlineplus.gov/sitemap.html"><span>Site Map</span></a></li>
<li><a target="_blank" href="https://support.nlm.nih.gov/knowledgebase/category/?id=CAT-01231&amp;category=medlineplus&amp;from=//medlineplus.gov/ency/article/003501.htm"><span>Customer Support</span></a></li>
</ul>
</div>
</div>
<!-- Nav Bar
================================================== -->
<div id="mplus-nav-bar">
<ul class="nav-list">
<li><a href="https://medlineplus.gov/healthtopics.html">Health Topics</a></li><li><a href="https://medlineplus.gov/druginformation.html">Drugs &amp; Supplements</a></li><li><a href="https://medlineplus.gov/genetics/">Genetics</a></li><li><a href="https://medlineplus.gov/lab-tests/">Medical Tests</a></li><li><a href="https://medlineplus.gov/encyclopedia.html">Medical Encyclopedia</a></li>
</ul>
</div>
<a title="Español" id="mplus-lang-toggle" href="../../spanish/ency/article/003501.htm">Español</a>
</div>
</div>
</header>
<!-- Content
================================================== -->
<div id="mplus-content">
<!-- Breadrcumbs -->
<div id="breadcrumbs"><div itemtype="http://schema.org/BreadcrumbList" itemscope="" itemprop="breadcrumb"><span class="hide-offscreen">You Are Here:</span>
<div itemscope itemprop="itemListElement" itemtype="http://schema.org/ListItem">
<a href="https://medlineplus.gov" itemprop="item"><span itemprop="name">Home</span></a>
&rarr;
<meta itemprop="position" content="1"/>
</div>
<div itemscope itemprop="itemListElement" itemtype="http://schema.org/ListItem">
<a href="https://medlineplus.gov/encyclopedia.html" itemprop="item"><span itemprop="name">Medical Encyclopedia</span></a>
&rarr;
<meta itemprop="position" content="2"/>
</div>
</div><div><span>Schirmer test</span></div></div>
<span class="page-url print-only">URL of this page: //medlineplus.gov/ency/article/003501.htm
</span>
<!-- Article -->
<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
</a><h1 class="with-also" itemprop="name">Schirmer test</h1>
</div><div class="page-actions">
</div>
<noscript>
<span class="js-disabled-message">To use the sharing features on this page, please enable JavaScript.</span>
</noscript></div><div class="main"><div id="ency_summary"><p>The Schirmer test determines whether the eye produces enough tears to keep it moist.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-1"><p>The eye doctor will place the end of a strip of filter paper inside the lower eyelid of each eye. Both eyes are tested at the same time. Before the test, you will be given numbing eye drops to prevent your eyes from tearing due to irritation from the paper strips.</p><p>The exact procedure may vary. Most often, the eyes are closed for 5 minutes. Close your eyes gently. Closing the eyes tightly or rubbing the eyes during the test can cause abnormal test results.</p><p>After 5 minutes, the doctor removes the paper and measures how much of it has become moist.</p><p>Sometimes the test is done without numbing drops to test for other types of tear problems.</p><p>The phenol red thread test is similar to the Schirmer test, except that red strips of special thread are used instead of paper strips. Numbing drops are not needed. The test takes 15 seconds.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How to Prepare for the Test</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-2"><p>You will be asked to remove your glasses or contact lenses before the test.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test will Feel</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-3"><p>Some people find that holding the paper against the eye is irritating or mildly uncomfortable. The numbing drops often sting at first.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Why the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-4"><p>This test is used when the eye doctor suspects you have dry eye. Symptoms include dryness of the eyes or excessive watering of the eyes.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Normal Results</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-5"><p>More than 10 mm of moisture on the filter paper after 5 minutes is a sign of normal tear production. Both eyes normally release the same amount of tears.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>What Abnormal Results Mean</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-6"><p>Dry eyes may result from:</p><ul><li>Aging</li><li>Swelling or inflammation of the eyelids (<a test="test" href="./001619.htm">blepharitis</a>)</li><li>Climate changes</li><li><a test="test" href="./001032.htm">Corneal ulcers and infections</a></li><li>Eye infections (for example, <a test="test" href="./001010.htm">conjunctivitis</a>)</li><li><a test="test" href="./007018.htm">Laser vision correction</a></li><li><a test="test" href="./001299.htm">Leukemia</a></li><li>Lymphoma (cancer of the lymph system)</li><li><a test="test" href="./000431.htm">Rheumatoid arthritis</a></li><li>Previous eyelid or facial surgery</li><li><a test="test" href="./000456.htm">Sjögren syndrome</a></li><li><a test="test" href="./002400.htm">Vitamin A deficiency</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Risks</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-7"><p>There are no risks with this test.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Considerations</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-8"><p>Do not rub the eyes for at least 30 minutes after the test. Leave contact lenses out for at least 2 hours after the test.</p><p>Even though the Schirmer test has been available since 1903, several studies show that it does not properly identify a large group of people with dry eyes. Newer and better tests are being developed. One test measures a molecule called lactoferrin. People with low tear production and dry eye have low levels of this molecule.</p><p>Another test measures tear osmolarity, or how concentrated the tears are. The higher the osmolarity, the more likely it is that you have dry eye.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-Alt"><p>Tear test; Tearing test; Dry eye test; Basal secretion test; Sjögren - Schirmer; Schirmer's test</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div name="Images" class="section-body" id="section-tnails"><ul class="img-grid group">
<li><img src="//medlineplus.gov/ency/images/ency/tnails/1094t.jpg" alt="Eye" title="Eye" class="side-img"/><a href="../imagepages/1094.htm">Eye</a></li>
<li><img src="//medlineplus.gov/ency/images/ency/tnails/9888t.jpg" alt="Schirmer's test" title="Schirmer's test" class="side-img"/><a href="../imagepages/9888.htm">Schirmer's test</a></li>
</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div class="section-body" id="section-Ref"><p>Akpek EK, Amescua G, Farid Ml; American Academy of Ophthalmology Preferred Practice Pattern Cornea and External Disease Panel, et al. Dry eye syndrome Preferred Practice Pattern. <em>Ophthalmology</em>. 2019;126(1):286-334. PMID: 30366798 <a href="https://pubmed.ncbi.nlm.nih.gov/30366798/" target="_blank">pubmed.ncbi.nlm.nih.gov/30366798/</a>.</p><p>Brissette AR, Bohm KJ, Starr CE. Dry eye overview: classification and treatment algorithm. In: Mannis MJ, Holland EJ, eds. <em>Cornea: Fundamentals, Diagnosis and Management</em>. 5th ed. Philadelphia, PA: Elsevier; 2022:chap 31.</p><p>Chuck RS, Dunn SP, Flaxel CJ; American Academy of Ophthalmology Preferred Practice Pattern Committee, et al. Comprehensive adult medical eye evaluation PPP 2020. <em>Ophthalmology</em>. 2021;128(1):1-29. <a href="https://www.aao.org/preferred-practice-pattern/comprehensive-adult-medical-eye-evaluation-ppp" target="_blank">www.aao.org/preferred-practice-pattern/comprehensive-adult-medical-eye-evaluation-ppp</a>. Published November 2020.</p><p>Salmon JF. Dry eye. In: Salmon JF, ed. <em>Kanski's Clinical Ophthalmology</em>. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 5.</p></div></div></section>
<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 2/12/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div>
<div id="section-version" class="section-body"><p>Updated by: Franklin W. Lusby, MD, Ophthalmologist, Lusby Vision Institute, La Jolla, CA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.</p>
</div></div></section><section><div class="section ency-citation"><div class="section-header"><div class="section-title ency-citation"><div id="citation-how-to"><button><span>Learn how to cite this page</span></button></div></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Related MedlinePlus Health Topics</h2></div><div class="section-button"><button type="submit" aria-controls="section-mtp" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
</div></div><div name="Related MedlinePlus Health Topics" class="section-body" id="section-mtp"><ul class="side-nav"><li><a href="https://medlineplus.gov/sjogrenssyndrome.html">Sjogren's Syndrome</a></li>
<li><a href="https://medlineplus.gov/tears.html">Tears</a></li>
</ul></div></div></section></div></div></article>
</div>
<footer>
<div class="provider-box group">
<div class="urac-logo">
<a href="https://accreditnet.urac.org/directory/#/certification/HCP-2/info"><img src="https://medlineplus.gov/images/CertifiedSeal.png"/></a>
<p class="urac-logo-info">Health Content Provider<br>06/01/2025</p>
</div>
<p class="adam-info">
<a href='javascript:urac_open();'>A.D.A.M., Inc. is accredited by URAC</a>, for Health Content Provider (www.urac.org). URAC's <a href='javascript:hwsopen();'>accreditation program</a> is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s <a href='javascript:edpolopen();'>editorial policy, editorial process</a>, and <a href='javascript:ppopen();'>privacy policy</a>. A.D.A.M. is also a founding member of Hi-Ethics. This site complies with the HONcode standard for trustworthy health information: <a href='javascript:honc_open();'>verify here</a>.
</p>
</div>
<p class="adam-info">
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997-2025 A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
</p>
<div class="adam-logo">
<a href="https://www.adam.com/about" target="_blank"><img width="49" height="10" alt="About A.D.A.M." src="https://medlineplus.gov/ency/images/ency/ftrAdamlogo.gif"/></a>
</div>
<div id="mplus-footer">
<div class="footer1">
<ul class="secondarynav">
<li><a href="https://medlineplus.gov/about/">About MedlinePlus</a></li>
<li><a href="https://medlineplus.gov/whatsnew/">What's New</a></li>
<li><a href="https://medlineplus.gov/sitemap.html">Site Map</a></li>
<li><a name="contact" target="_blank" href="https://support.nlm.nih.gov/knowledgebase/category/?id=CAT-01231&amp;category=medlineplus&amp;from="><span>Customer Support</span></a></li>
</ul>
<ul class="follow-footer">
<li><a href="https://medlineplus.gov/rss.html" class="follow-item">Subscribe to RSS<img src="https://medlineplus.gov/images/feed.png" class="social-media-toolkit-icon" alt="RSS" title="RSS"></a></li>
<li><span class="follow-label">Follow us</span>
<a href="https://twitter.com/medlineplus" class="follow-item" target="_blank"><img src="https://medlineplus.gov/images/i_share_twitter.png" class="follow-icon" alt="X" title="X"></a>
<a href="https://facebook.com/Mplus.gov/" class="follow-item" target="_blank"><img src="https://medlineplus.gov/images/i_share_fb.png" class="follow-icon" alt="Facebook" title="Facebook"></a>
<a href="https://www.instagram.com/mplusgov/" class="follow-item" target="_blank"><img src="https://medlineplus.gov/images/Instagram_Glyph_Gradient_RGB.png" class="follow-icon" alt="Instagram" title="Instagram"></a>
</li>
<li><a href="https://medlineplus.gov/social-media-toolkit/" class="social-media-toolkit-item">Social Media Toolkit<img src="https://medlineplus.gov/images/i_social_media_toolkit.png" class="social-media-toolkit-icon" alt="Social Media Toolkit" title="Social Media Toolkit"></a></li>
</ul>
</div>
<div class="footer2">
<ul>
<li><a href="https://www.nlm.nih.gov/web_policies.html" target="_blank">NLM Web Policies</a></li>
<li><a href="https://medlineplus.gov/about/using/usingcontent/" >Copyright</a></li>
<li><a href="//medlineplus.gov/accessibility.html">Accessibility</a></li>
<li><a href="https://medlineplus.gov/about/using/criteria/">Guidelines for Links</a></li>
<li><a href="//medlineplus.gov/plugins.html">Viewers &amp; Players</a></li>
<li><a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" target="_blank">HHS Vulnerability Disclosure</a></li>
<li><a href="https://medlineplus.gov/medlineplus-connect/">MedlinePlus Connect for EHRs</a></li>
<li><a href="https://medlineplus.gov/about/developers/">For Developers</a></li>
</ul>
<div class="address">
<a href="//www.nlm.nih.gov" target="_blank">National Library of Medicine</a>
<span>8600 Rockville Pike, Bethesda, MD 20894</span>
<a href="//www.hhs.gov" target="_blank">U.S. Department of Health and Human Services</a>
<a href="//www.nih.gov" target="_blank">National Institutes of Health</a>
</div>
<div class="return-top"><a href="#top" title="Return to top"><img class="return-top-icon" alt="Return to top" src="https://medlineplus.gov/images/return-top.png"></a></div>
</div>
</div>
</footer>
</div><!-- End Wrap -->
<script src="https://medlineplus.gov/jslib/jquery-3.6.0.min.js" type="text/javascript">
</script>
<script src="https://medlineplus.gov/jslib/mplus-frontend-controls.js" type="text/javascript">
</script>
<!--[if lte IE 9]>
<script src="https://medlineplus.gov/jslib/jquery.placeholder.js" type="text/javascript"></script>
<![endif]-->
<script src="https://medlineplus.gov/jslib/mplus-share.js?id=1112022" type="text/javascript">
</script>
<script src="https://medlineplus.gov/jslib/control.js" type="text/javascript">
</script>
<script src="https://medlineplus.gov/uswds/js/uswds.min.js" type="text/javascript">
</script>
<script src="https://medlineplus.gov/jslib/ency/ency.js" type="text/javascript">
</script>
</body>
</html>