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<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also" itemprop="name">Acid mucopolysaccharides</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Acid mucopolysaccharides is a test that measures the amount of <a test="test" href="./002263.htm">mucopolysaccharides</a> released into the urine either during one episode or over a 24-hour period.</p><p>Mucopolysaccharides are long chains of sugar molecules in the body. They are often found in mucus and in fluid around the joints.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>For the 24-hour test, you must urinate into a special bag or container every time you use the bathroom. Most often, you will be given two containers. You will urinate directly into the smaller special container and then transfer that urine into the other larger container.</p><ul><li>On day 1, urinate into the toilet when you wake up in the morning.</li><li>After the first urination, urinate into the special container every time you use the bathroom for the next 24 hours. Transfer the urine into the larger container and keep the larger container in a cool place or in a refrigerator. Keep this container tightly capped.</li><li>On day 2, urinate into the container in the morning again when you wake up and transfer this urine to the larger container.</li><li>Label the larger container with your name, the date, the time of completion, and return it as instructed. </li></ul><p>For an infant:</p><p>Thoroughly wash the area around the urethra (the hole where urine flows out). Open a urine collection bag (a plastic bag with an adhesive paper on one end).</p><ul><li>For males, place the entire penis in the bag and attach the adhesive paper to the skin.</li><li>For females, place the bag over the two folds of skin on either side of the vagina (labia). Put a diaper on the baby (over the bag). </li></ul><p>Check the infant often, and change the bag after the infant has urinated. Empty the urine from the bag into the container provided by your health care provider.</p><p>Active babies can move the bag, causing the urine to go into the diaper. You may need extra collection bags.</p><p>When finished, label the container and return it as you have been told.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How to Prepare for the Test</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>There is no special preparation needed.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test will Feel</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>The test involves only normal urination, and there is no discomfort.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Why the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>This test is done to diagnose a rare group of genetic disorders called mucopolysaccharidoses (MPS). These include, Hurler, Scheie, and Hurler/Scheie syndromes (MPS I), Hunter syndrome (MPS II), Sanfilippo syndrome (MPS III), Morquio syndrome (MPS IV), Maroteaux-Lamy syndrome (MPS VI), and Sly syndrome (MPS VII).</p><p>Most of the time, this test is done in infants who may have a symptom or family history of one of these disorders.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Normal Results</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Normal levels vary with age and from lab to lab. Talk to your provider about the meaning of your specific test results.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>What Abnormal Results Mean</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Abnormally high levels could indicate a type of mucopolysaccharidosis. Further tests are needed to determine the specific type of mucopolysaccharidosis.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>AMP; Dermatan sulfate - urine; Urine heparan sulfate; Urine dermatan sulfate; Heparan sulfate - urine</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Kumar V, Abbas AK, Aster JC. Genetic disorders. In: Kumar V, Abbas AK, Aster JC, eds. <em>Robbins & Cotran Pathologic Basis of Disease</em>. 10th ed. Philadelphia, PA: Elsevier; 2021:chap 5.</p><p>Spranger JW. Mucopolysaccharidoses. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. <em>Nelson Textbook of Pediatrics</em>. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 107.</p><p>Turnpenny PD, Ellard S, Cleaver R. Inborn errors of metabolism. In: Turnpenny PD, Ellard S, Cleaver R, eds. <em>Emery's Elements of Medical Genetics and Genomics</em>. 16th ed. Philadelphia, PA: Elsevier; 2022:chap 18.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 4/24/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Anna C. Edens Hurst, MD, MS, Associate Professor in Medical Genetics, The University of Alabama at Birmingham, Birmingham, AL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. </p>
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