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</div><div><span>Apert syndrome</span></div></div>
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</a><h1 class="with-also" itemprop="name">Apert syndrome</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Apert syndrome is a genetic disease in which the seams between the skull bones close earlier than normal. This affects the shape of the head and face. Children with Apert syndrome often have deformities of the hands and feet as well.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>Apert syndrome can be passed down through families (inherited) as an <a test="test" href="./002049.htm">autosomal dominant</a> trait. This means that only one parent needs to pass on the altered gene to a child to have the condition.</p><p>Most cases may occur without a known family history.</p><p>Apert syndrome is caused by one of two changes to the <em>FGFR2</em> gene. This gene change causes some of the bony sutures of the skull to close too early. This condition is called <a test="test" href="./001590.htm">craniosynostosis</a>.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Symptoms include:</p><ul><li>Early closure of sutures between bones of the skull, noted by ridging along sutures (craniosynostosis)</li><li>Frequent ear infections</li><li>Fusion or severe webbing of the 2nd, 3rd, and 4th fingers, often called "mitten hands"</li><li>Hearing loss</li><li>Large or late-closing soft spot on a baby's skull (fontanelle)</li><li>Possible, slow intellectual development (varies from person to person)</li><li>Prominent or bulging eyes</li><li>Severe under-development of the midface</li><li><a test="test" href="./003170.htm">Skeletal (limb) abnormalities</a></li><li>Short height</li><li>Webbing or fusion of the toes </li></ul><p>Several other syndromes can lead to a similar appearance of the face and head, but do not include the severe hand and foot features of Apert syndrome. These similar syndromes include:</p><ul><li>Carpenter syndrome (kleeblattschadel, cloverleaf skull deformity)</li><li>Crouzon disease (craniofacial dysostosis)</li><li>Pfeiffer syndrome</li><li>Saethre-Chotzen syndrome </li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>Your health care provider will perform a physical exam. Hand, foot, and <a test="test" href="./003802.htm">skull x-rays</a> will be done. Hearing tests should always be performed.</p><p>Genetic testing can confirm the diagnosis of Apert syndrome.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>Treatment consists of surgery to correct abnormal bone growth of the skull, as well as for the fusion of the fingers and toes. Children with this disorder should be examined by a specialized craniofacial surgery team at a children's medical center.</p><p>A hearing specialist should be consulted if there are hearing problems.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Support Groups</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>More information and support for people with Apert syndrome and their families can be found at:</p><ul><li>Children's Craniofacial Association: <a class="extln" target="_blank" href="https://ccakids.org/">ccakids.org</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Contact your provider if you have a family history of Apert syndrome or you notice your baby's skull is not developing normally.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Prevention</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Genetic counseling may be helpful if you have a family history of this disorder and are planning to become pregnant. Your provider can test your baby for this disease during pregnancy.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Acrocephalosyndactyly</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/1763t.jpg" alt="Syndactyly" title="Syndactyly" class="side-img"/><a href="../imagepages/1763.htm">Syndactyly</a></li>
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Goldstein JA, Davit AJ, Losee JE. Pediatric plastic surgery. In: Zitelli BJ, McIntire SC, Nowalk AJ, Garrison J, eds. <em>Zitelli and Davis' Atlas of Pediatric Physical Diagnosis. </em>8th ed. Philadelphia, PA: Elsevier; 2023:chap 23.</p><p>Kinsman SL, Johnston MV. Congenital anomalies of the central nervous system. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. <em>Nelson Textbook of Pediatrics.</em> 21st ed. Philadelphia, PA: Elsevier; 2020:chap 609.</p><p>Mauck BM. Congenital anomalies of the hand. In: Azar FM, Beaty JH, eds. <em>Campbell's Operative Orthopaedics.</em> 14th ed. Philadelphia, PA: Elsevier; 2021:chap 80.</p><p>National Center for Advancing Translational Sciences. Genetic and Rare Diseases Information Center website. Apert syndrome. <a href="https://rarediseases.info.nih.gov/diseases/5833/apert-syndrome" target="_blank">rarediseases.info.nih.gov/diseases/5833/apert-syndrome</a>. Updated February 2023. Accessed October 17, 2023.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 9/18/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Anna C. Edens Hurst, MD, MS, Associate Professor in Medical Genetics, The University of Alabama at Birmingham, Birmingham, AL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.</p>
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