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</div><div><span>Retinitis pigmentosa</span></div></div>
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</a><h1 class="with-also" itemprop="name">Retinitis pigmentosa</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Retinitis pigmentosa is an eye disease in which there is damage to the <a test="test" href="./002291.htm">retina</a>. The retina is the layer of tissue at the back of the inner eye. This layer converts light images to nerve signals and sends them to the brain.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>Retinitis pigmentosa can run in families. The disorder can be caused by several genetic defects.</p><p>The cells controlling night vision (rods) are most likely to be affected. However, in some cases, retinal cone cells are damaged the most. The main sign of the disease is the presence of dark deposits in the retina.</p><p>The main risk factor is a family history of retinitis pigmentosa. It is a rare condition affecting about 1 in 4,000 people in the United States.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Symptoms often first appear in childhood. However, severe vision problems do not often develop before early adulthood.</p><ul><li>Decreased vision at night or in low light. Early signs may include having a harder time moving around in the dark.</li><li>Loss of side (peripheral) vision, causing "tunnel vision."</li><li>Loss of <a test="test" href="./002311.htm">central</a> vision (in advanced cases). This will affect the ability to read.</li><li>Loss of color vision</li><li>Sensitivity to bright light</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>Tests to evaluate the retina:</p><ul><li>Color vision</li><li>Exam of the retina by <a test="test" href="./003881.htm">ophthalmoscopy</a> after the pupils have been dilated</li><li><a test="test" href="./003846.htm">Fluorescein angiography</a></li><li><a test="test" href="./003447.htm">Intraocular pressure</a></li><li>Measurement of the electrical activity in the retina (<a test="test" href="./003388.htm">electroretinogram</a>)</li><li>Pupil reflex response</li><li><a test="test" href="./003844.htm">Refraction test</a></li><li><a test="test" href="./003846.htm">Retinal photography</a></li><li>Side vision test (visual field test)</li><li><a test="test" href="./003880.htm">Slit lamp examination</a></li><li><a test="test" href="./003396.htm">Visual acuity</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>There is no effective treatment for this condition. Wearing sunglasses to protect the retina from ultraviolet light may help preserve vision.</p><p>Some studies suggest that treatment with antioxidants (such as high doses of vitamin A palmitate) may slow the disease. However, taking high doses of vitamin A can cause serious liver problems. The benefit of treatment has to be weighed against risks to the liver.</p><p>Clinical trials are in progress to assess new treatments for retinitis pigmentosa, including the:</p><ul><li>Use of DHA, which is an omega-3 fatty acid.</li><li>Treatments related to the possible genetic causes of this disorder</li></ul><p>Other treatments, such as microchip implants into the retina that act like a microscopic video camera, are in the early stages of development. These treatments may be useful for treating blindness associated with RP and other serious eye conditions.</p><p>A vision specialist can help you adapt to vision loss. Make regular visits to an eye care specialist, who can detect <a test="test" href="./001001.htm">cataracts</a> or retinal swelling. Both of these problems can be treated.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>The disorder will continue to progress slowly. Complete blindness is uncommon.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Possible Complications</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Peripheral and central <a test="test" href="./003040.htm">loss of vision</a> will occur over time.</p><p>People with retinitis pigmentosa often develop cataracts at an early age. They may also develop swelling of the retina (macular edema). Cataracts can be removed if they contribute to vision loss.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Contact your health care provider if you have problems with night vision or you develop other symptoms of this disorder.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Prevention</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-8"><p>Genetic counseling and testing may help determine whether your children are at risk for this disease.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>RP; Vision loss - RP; Night vision loss - RP; Rod Cone dystrophy; Peripheral vision loss - RP; Night blindness</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>American Academy of Ophthalmology website. New treatments for retinitis pigmentosa. <a href="https://www.aao.org/eye-health/tips-prevention/gene-therapy-new-retinitis-pigmentosa-lca-luxturna" target="_blank">www.aao.org/eye-health/tips-prevention/gene-therapy-new-retinitis-pigmentosa-lca-luxturna</a>. Updated August 16, 2021. Accessed February 20, 2024.</p><p>Cioffi GA, Liebmann JM. Diseases of the visual system. In: Goldman L, Cooney KA, eds. <em>Goldman-Cecil Medicine</em>. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 391.</p><p>Cukras CA, Zein WM, Sieving PA. Progressive and 'stationary' inherited retinal degenerations. In: Yanoff M, Duker JS, eds. <em>Ophthalmology</em>. 6th ed. Philadelphia, PA: Elsevier; 2023:chap 6.12.</p><p>Gregory-Evans K, Yang P, Pennesi ME. Retinitis pigmentosa and allied disorders. In: Sadda SR, Sarraf D, Freund KB, et al , eds. <em>Ryan's Retina</em>. 7th ed. Philadelphia, PA: Elsevier; 2023:chap 43.</p><p>Olitisky SE, Marsh JD. Disorders of the retina and vitreous. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. <em>Nelson Textbook of Pediatrics</em>. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 648.</p></div></div></section>
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