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</a><h1 class="with-also" itemprop="name">Drug-induced thrombocytopenia</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p><a test="test" href="./000586.htm">Thrombocytopenia</a> is any disorder in which there are not enough platelets. Platelets are elements in the blood that help the blood clot. A low platelet count makes bleeding more likely.</p><p>When medicines or drugs cause a low platelet count, it is called drug-induced thrombocytopenia.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>Drug-induced thrombocytopenia occurs when certain medicines destroy platelets or interfere with the body's ability to make enough of them.</p><p>There are two types of drug-induced thrombocytopenia: immune and nonimmune.</p><p>If a medicine causes your immune system to produce <a test="test" href="./002223.htm">antibodies</a> which seek and destroy your platelets, the condition is called drug-induced immune thrombocytopenia. Heparin, a blood thinner, is the most common cause of drug-induced immune thrombocytopenia.</p><p>If a medicine prevents your bone marrow from making enough platelets, the condition is called drug-induced nonimmune thrombocytopenia. <a test="test" href="./002324.htm">Chemotherapy</a> drugs and a seizure medicine called valproic acid may lead to this problem.</p><p>Other medicines that cause drug-induced thrombocytopenia include:</p><ul><li>
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Furosemide</li><li>Gold, used to treat arthritis</li><li>Nonsteroidal anti-inflammatory drugs (NSAIDs)</li><li>Penicillin</li><li>Quinidine</li><li>Quinine</li><li>Ranitidine</li><li>Sulfonamides</li><li>Linezolid and other antibiotics</li><li>Statins</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Decreased platelets may cause:</p><ul><li>Abnormal bleeding</li><li>Bleeding when you brush your teeth</li><li>Easy <a test="test" href="./007213.htm">bruising</a></li><li>Pinpoint red spots on the skin (<a test="test" href="./003235.htm">petechiae</a>)</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>The first step is to stop using the medicine that is causing the problem.</p><p>For people who have life-threatening bleeding, treatments may include:</p><ul><li>Immunoglobulin therapy (IVIG) given through a vein</li><li>Plasma exchange (plasmapheresis)</li><li>Platelet transfusions</li><li>Corticosteroid medicine</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Possible Complications</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>Bleeding can be life threatening if it occurs in the brain or certain other organs.</p><p>A pregnant woman who has antibodies to platelets may pass the antibodies to the baby in the womb.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Contact your health care provider if you have unexplained bleeding or bruising and are taking medicines, such as the ones mentioned above under Causes.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Drug-induced thrombocytopenia; Immune thrombocytopenia - drug</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/19462t.jpg" alt="Blood clot formation" title="Blood clot formation" class="side-img"/><a href="../imagepages/19462.htm">Blood clot formation</a></li>
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/9326t.jpg" alt="Blood clots" title="Blood clots" class="side-img"/><a href="../imagepages/9326.htm">Blood clots</a></li>
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Abrams CS. Thrombocytopenia. In: Goldman L, Cooney KA, eds. <em>Goldman-Cecil Medicine</em>. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 158.</p><p>Warkentin TE. Thrombocytopenia caused by hypersplenism, platelet destruction, or surgery/hemodilution. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. <em>Hematology: Basic Principles and Practice</em>. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 130.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 4/18/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: John Roberts, MD, Professor of Internal Medicine (Medical Oncology), Yale Cancer Center, New Haven, CT. He is board certified in Internal Medicine, Medical Oncology, Pediatrics, Hospice and Palliative Medicine. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. </p>
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