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</div><div><span>Marfan syndrome</span></div></div>
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<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also" itemprop="name">Marfan syndrome</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Marfan syndrome is a disorder of connective tissue. This is the tissue that strengthens the body's structures.</p><p>Disorders of connective tissue affect the skeletal system, cardiovascular system, eyes, and skin.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>Marfan syndrome is caused by variants in a gene called fibrillin-1. Fibrillin-1 plays an important role as the building block for connective tissue in the body.</p><p>The gene variant also causes the long bones of the body to grow too much. People with this syndrome have tall height and long arms and legs. How this overgrowth happens is not well understood.</p><p>Other areas of the body that are affected include:</p><ul><li>Lung tissue (there may be a pneumothorax, in which air can escape from the lung into the chest cavity and collapse the lung)</li><li>The aorta, the main blood vessel that takes blood from the heart to the body may stretch or become weak (called aortic dilation or aortic aneurysm)</li><li>The heart valves</li><li>The eyes, causing cataracts and other problems (such as a dislocation of the lenses)</li><li>The skin</li><li>Tissue covering the spinal cord </li><li>The joints</li></ul><p>In most cases, Marfan syndrome is passed down through families (inherited). However, up to 30% of people have no family history, which is called "sporadic." In sporadic cases, the syndrome is believed to be caused by a new gene change.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>People with Marfan syndrome are often tall with long, thin arms and legs and spider-like fingers (called arachnodactyly). The length of the arms is greater than height when arms are stretched out. </p><p>Other symptoms include:</p><ul><li>A chest that sinks in or sticks out, called funnel chest (<a test="test" href="./003320.htm">pectus excavatum</a>) or pigeon breast (<a test="test" href="./003321.htm">pectus carinatum</a>)</li><li>Flat feet</li><li>Highly arched palate and crowded teeth</li><li><a test="test" href="./003298.htm">Hypotonia</a> of muscles (low muscle tone)</li><li>Joints that are too flexible (but the elbows may be less flexible)</li><li>Learning disability</li><li>Movement of the lens of the eye from its normal position (dislocation)</li><li>Nearsightedness</li><li>Small lower jaw (micrognathia)</li><li>Spine that curves to one side (<a test="test" href="./001241.htm">scoliosis</a>)</li><li>Thin, narrow face </li></ul><p>Many people with Marfan syndrome suffer from chronic muscle and joint pain.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>The health care provider will perform a physical exam. The joints may move around more than normal. There may also be signs of:</p><ul><li><a test="test" href="./001119.htm">Aneurysm</a></li><li>Collapsed lung</li><li>Heart valve problems </li></ul><p>An eye exam may show:</p><ul><li>Defects of the lens or cornea</li><li><a test="test" href="./001027.htm">Retinal detachment</a></li><li>Vision problems </li></ul><p>The following tests may be performed:</p><ul><li><a test="test" href="./003869.htm">Echocardiogram</a></li><li>Fibrillin-1 mutation testing (in some people) </li></ul><p>An echocardiogram or another test should be done every year to look at the base of the aorta and possibly the heart valves. Depending on the results, you may need this test less often than yearly.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>Vision problems should be treated when possible.</p><p>Monitor for scoliosis, especially during the teenage years.</p><p>Medicine to slow the heart rate and lower blood pressure may help prevent stress on the aorta. To avoid injuring the aorta, people with the condition may have to modify their activities. Some people may need surgery to replace the aortic root and valve.</p><p>Pregnant women with Marfan syndrome must be monitored very closely because of the increased stress on the heart and aorta.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Support Groups</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>More information and support for people with Marfan syndrome and their families can be found at:</p><ul><li>The Marfan Foundation -- <a class="extln" target="_blank" href="https://marfan.org/">marfan.org</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Heart-related complications may shorten the lifespan of people with this disease. However, many people live into their 60s and beyond. Good care and surgery may further extend lifespan.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Possible Complications</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Complications may include:</p><ul><li><a test="test" href="./000179.htm">Aortic regurgitation</a></li><li>Aortic rupture</li><li>Bacterial endocarditis</li><li><a test="test" href="./000181.htm">Dissecting aortic aneurysm</a> (also called aortic dissection) </li><li>Enlargement of the base of the aorta</li><li><a test="test" href="./000158.htm">Heart failure</a></li><li>Mitral valve prolapse</li><li>Scoliosis</li><li>Vision problems </li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-8"><p>Couples who have this condition and are planning to have children may want to talk to a genetic counselor before starting a family. </p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Prevention</h2></div><div class="section-button"><button type="submit" aria-controls="section-9" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-9"><p>Spontaneous new gene variants leading to Marfan syndrome (less than one third of cases) cannot be prevented. If you have Marfan syndrome, see your provider at least once every year.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Aortic aneurysm - Marfan</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/2927t.jpg" alt="Pectus excavatum" title="Pectus excavatum" class="side-img"/><a href="../imagepages/2927.htm">Pectus excavatum</a></li>
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/9611t.jpg" alt="Marfan syndrome" title="Marfan syndrome" class="side-img"/><a href="../imagepages/9611.htm">Marfan syndrome</a></li>
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</div></div><div class="section-body" id="section-Ref"><p>Doyle JJ, Dietz HC. Marfan syndrome. In: Kliegman RM, St. Geme JW, Blum NJ, et al. eds. <em>Nelson Textbook of Pediatrics.</em> 22nd ed. Philadelphia, PA: Elsevier; 2025:chap 743.</p><p>Madan-Khetarpal S, Arnold G, Ortiz D. Genetic disorders and dysmorphic conditions. In: Zitelli BJ, McIntire SC, Nowalk AJ, Garrison J, eds. <em>Zitelli and Davis' Atlas of Pediatric Diagnosis.</em> 8th ed. Philadelphia, PA: Elsevier; 2023:chap 1.</p><p>Pyeritz RE. Inherited diseases of connective tissue. In: Goldman L, Cooney KA, eds.<em> Goldman-Cecil Medicine.</em> 27th ed. Philadelphia, PA: Elsevier; 2024:chap 239.</p></div></div></section>
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