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</div><div><span>Peutz-Jeghers syndrome</span></div></div>
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<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also" itemprop="name">Peutz-Jeghers syndrome</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Peutz-Jeghers syndrome (PJS) is a rare disorder in which growths called polyps form in the intestines. A person with PJS has a high risk for developing certain cancers.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>It is unknown how many people are affected by PJS. However, the National Institutes of Health estimates that it affects about 1 in 50,000 to 200,000 people.</p><p>PJS is caused by a mutation in the gene called STK11 (previously known as LKB1). There are two ways that PJS can occur:</p><ul><li>Familial PJS is inherited in families as an <a test="test" href="./002049.htm">autosomal dominant</a> trait. That means if one of your parents has this type of PJS, you have a 50% chance of inheriting the gene and having the disease.</li><li>Spontaneous PJS is not inherited from a parent. The gene mutation occurs on its own. Once someone carries the genetic change, their children have a 50% chance of inheriting it.</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Symptoms of PJS are:</p><ul><li>Brownish or bluish-gray spots on the lips, gums, inner lining of the mouth, and skin</li><li><a test="test" href="./003282.htm">Clubbed fingers or toes</a></li><li>Cramping pain in the belly area</li><li>Dark freckles on and around the lips of a child</li><li><a test="test" href="./003130.htm">Blood in the stool</a> that can be seen with the naked eye (sometimes)</li><li>Vomiting</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>The polyps develop mainly in the small intestine, but also in the large intestine (colon). An exam of the colon called a <a test="test" href="./003886.htm">colonoscopy</a> will show colon polyps. The small intestine is evaluated in two ways. One is a barium x-ray (small bowel series). The other is a capsule endoscopy, in which a small camera is swallowed and then takes many pictures as it travels through the small intestine.</p><p>Additional exams may show:</p><ul><li>
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Part of the intestine folded in on itself (<a test="test" href="./000958.htm">intussusception</a>)</li><li>Benign (noncancerous) tumors in the nose, airways, ureters, or bladder</li></ul><p>Laboratory tests may include:</p><ul><li>Complete blood count (CBC) -- may reveal <a test="test" href="./000560.htm">anemia</a></li><li>Genetic testing</li><li><a test="test" href="./003393.htm">Stool occult blood</a>, to look for blood in stool</li><li><a test="test" href="./003489.htm">Total serum iron and iron-binding capacity</a> (TIBC) -- may indicate iron-deficiency anemia</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>Surgery may be needed to remove polyps that cause long-term problems. Iron supplements help counteract blood loss.</p><p>People with this condition should be monitored by a health care provider and checked regularly for cancerous polyp changes.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Support Groups</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>More information and support for people with PJS and their families can be found at:</p><ul><li>National Organization for Rare Disorders (NORD) -- <a class="extln" target="_blank" href="https://rarediseases.org/rare-diseases/peutz-jeghers-syndrome">rarediseases.org/rare-diseases/peutz-jeghers-syndrome</a></li><li>Genetic and Rare Diseases Information Center (GARD) -- <a class="extln" target="_blank" href="https://rarediseases.info.nih.gov/diseases/7378/peutz-jeghers-syndrome">rarediseases.info.nih.gov/diseases/7378/peutz-jeghers-syndrome</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>There may be a high risk for these polyps becoming cancerous. Some studies link PJS with cancers of the gastrointestinal tract, lung, breast, uterus, and ovaries.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Possible Complications</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Complications may include:</p><ul><li>Intussusception</li><li>Polyps that lead to cancer</li><li><a test="test" href="./001504.htm">Ovarian cysts</a></li><li>A type of ovarian tumors called sex cord tumors</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-8"><p>Contact your provider for an appointment if you or your child has symptoms of this condition. Severe abdominal pain may be a sign of an emergency condition such as intussusception.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Prevention</h2></div><div class="section-button"><button type="submit" aria-controls="section-9" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-9"><p>Genetic counseling is recommended if you are planning to have children and have a family history of this condition.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>PJS</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Garber JJ, Chung DC. Colonic polyps and polyposis syndromes. In: Feldman M, Friedman LS, Brandt LJ, eds. <em>Sleisenger and Fordtran's Gastrointestinal and Liver Disease</em>. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 126.</p><p>McGarrity TJ, Amos CI, Baker MJ. Peutz-Jeghers syndrome. In: Adam MP, Ardinger HH, Pagon RA, et al, eds. <em>GeneReviews</em>. Seattle, WA: University of Washington. <a href="https://www.ncbi.nlm.nih.gov/books/NBK1266/" target="_blank">www.ncbi.nlm.nih.gov/books/NBK1266/</a>. Updated September 2, 2021. Accessed April 18, 2024.</p><p>Zahler SG, Kabbany MN, Murray KF. Tumors of the digestive tract. In: Kliegman RM, St. Geme JW, Blum NJ, et al, eds. <em>Nelson Textbook of Pediatrics</em>. 22nd ed. Philadelphia, PA: Elsevier; 2025:chap 393.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 12/31/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Anna C. Edens Hurst, MD, MS, Associate Professor in Medical Genetics, The University of Alabama at Birmingham, Birmingham, AL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. </p>
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