823 lines
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823 lines
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<p>Use these free digital, outreach materials in your community and on social media to spread the word about mental health.</p>
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<p>NIMH supports research at universities, medical centers, and other institutions via grants, contracts, and cooperative agreements. Learn more about NIMH research areas, policies, resources, and initiatives.</p>
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<p>The Division of Intramural Research Programs (IRP) is the internal research division of the NIMH. Over 40 research groups conduct basic neuroscience research and clinical investigations of mental illnesses, brain function, and behavior at the NIH campus in Bethesda, Maryland. Learn more about research conducted at NIMH.</p>
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<p>Learn about NIMH priority areas for research and funding that have the potential to improve mental health care over the short, medium, and long term.</p>
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<p>Read more about the NIMH Strategic Plan for Research, Strategic Research Priorities, the anatomy of NIMH funding, and our yearly funding strategy for research grants.</p>
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<p>Find the latest NIH and NIMH policies, guidance, and resources for clinical research.</p>
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<h1 class="splashBanner__title" >Genomics Research</h1>
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<div class="field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Genomics research funded by the National Institute of Mental Health aims to deepen our understanding of the genomic and non-genomic factors (such as environment) that contribute to the development of mental illnesses. The ultimate goal of this research is to improve current approaches to diagnose, treat, and prevent mental disorders.</p><p>In 2018, the National Advisory Mental Health Council Workgroup on Genomics established <a href="/about/advisory-boards-and-groups/namhc/reports/report-of-the-national-advisory-mental-health-council-workgroup-on-genomics" data-entity-type="node" data-entity-uuid="df9ff2cd-228a-4a63-b757-afce386efb2d" data-entity-substitution="canonical">criteria for rigorous genomics</a> research. The Genomics Team implements these recommendations across NIMH-funded projects and the genomics research priorities described in the <a href="/about/strategic-planning-reports" data-entity-type="node" data-entity-uuid="7db249bf-8c01-4a5b-b70e-2aedc818e0f7" data-entity-substitution="canonical">NIMH Strategic Plan for Research</a>.</p><p>The Genomics Team establishes genomics initiatives and programs through funding opportunity announcements. These opportunities span basic, clinical, and translational research and could help establish a framework for translating genetic findings into clinical applications (e.g., risk prediction, diagnostics, therapeutic, and prognostic).</p><p>The team also develops initiatives that have the potential to advance and transform our understanding of how disease risk genes cause changes in brain function and behavior. An example includes the <a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-22-111.html" rel="external">Genes to Biology initiative <i class="fa-solid fa-arrow-up-right-from-square ext-link-icon"></i></a>. Through this initiative, researchers will systematically evaluate the neurobiology of psychiatric risk genes and establish a harmonized cross-modality and cross-species phenotypic data resource. In addition, the team seeks to advance <a href="/news/events/2021/workshop-gene-based-therapeutics-for-rare-genetic-neurodevelopmental-psychiatric-disorders" data-entity-type="node" data-entity-uuid="23285960-4ecb-4a6b-92cf-f74f3cdaa487" data-entity-substitution="canonical">gene-based therapeutics research</a> for rare genetic neurodevelopmental disorders for which targeted, gene-based treatments are not currently available.</p><h3>Resources for researchers planning to study specific genes </h3><p class="MsoNormal"><a href="/about/advisory-boards-and-groups/namhc/reports/namhc-genomics-workgroup-research-recommendations-summary" data-entity-type="node" data-entity-uuid="6787733d-72d0-41e1-bd19-c088725392c0" data-entity-substitution="canonical">NIMH supports research</a> for genes that exhibit significant evidence, at a genome-wide level, of association with a particular trait regardless of whether the variation is rare or common. To help researchers understand how NIMH evaluates grant applications related to studying specific genes, we have created two resources:<p></p></p><ol><li><a href="/sites/default/files/documents/research/research-funded-by-nimh/NIMH_gene_list_version01_2023-09-21.xlsx" data-entity-type="media" data-entity-uuid="dbc48b9c-a4aa-48c1-ac7e-874fea6c665c" data-entity-substitution="media">A list of human genes</a> that have demonstrated genome-wide association with mental illness through rare variation</li><li><a href="/sites/default/files/documents/research/research-funded-by-nimh/NIMH_gene_list_documentation_version01_2023-09-21.docx" data-entity-type="media" data-entity-uuid="111184e5-a669-4697-8f60-271b66b4cae0" data-entity-substitution="media">Detailed documentation</a> that explains the rationale behind the list</li></ol><p class="MsoNormal">While the list focuses on rare genetic variation, NIMH is open to supporting studies on genes that are not included. We actively encourage dialogue with the research community regarding the list and any proposed genes for investigation. For further inquiries, please contact us at <a href="mailto:NIMHgenes@nih.gov">NIMHgenes@nih.gov</a>.<p></p></p><h3>Recent meetings and events</h3><div class="group equal"><div class="col-md-4 col-sm-4 col-xs-12 margin-top-sm"><div class="border-box text-small pad-small"><a href="/news/events/2021/workshop-advanced-statistical-methods-and-dynamic-data-visualizations-for-mental-health-studies" data-entity-type="node" data-entity-uuid="f21ec484-d2c0-4cf2-a0e0-52f29ed88ae5" data-entity-substitution="canonical"><em><i class="fas fa-file-video">​</i></em></a> <br><a href="/news/events/2021/workshop-advanced-statistical-methods-and-dynamic-data-visualizations-for-mental-health-studies" data-entity-type="node" data-entity-uuid="f21ec484-d2c0-4cf2-a0e0-52f29ed88ae5" data-entity-substitution="canonical">Workshop: Advanced Statistical Methods and Dynamic Data Visualizations for Mental Health Studies</a> <br>June 28, 2021 - June 30, 2021</div></div><div class="col-md-4 col-sm-4 col-xs-12 margin-top-sm"><div class="border-box text-small pad-small"><a href="/news/events/2021/directors-innovation-speaker-series-genetic-clues-to-autism-heterogeneity" data-entity-type="node" data-entity-uuid="a8f1b756-0e60-4ada-b515-9a5f941080fa" data-entity-substitution="canonical"><em><i class="fas fa-file-video">​</i></em></a> <br><a href="/news/events/2021/directors-innovation-speaker-series-genetic-clues-to-autism-heterogeneity" data-entity-type="node" data-entity-uuid="a8f1b756-0e60-4ada-b515-9a5f941080fa" data-entity-substitution="canonical">The NIMH Director’s Innovation Speaker Series: Genetic Clues to Autism Heterogeneity</a> <br>May 13, 2021</div></div><div class="col-md-4 col-sm-4 col-xs-12 margin-top-sm"><div class="border-box text-small pad-small"><a href="/news/events/2021/workshop-gene-based-therapeutics-for-rare-genetic-neurodevelopmental-psychiatric-disorders" data-entity-type="node" data-entity-uuid="23285960-4ecb-4a6b-92cf-f74f3cdaa487" data-entity-substitution="canonical"><em><i class="fas fa-file-video">​</i></em></a> <br><a href="/news/events/2021/workshop-gene-based-therapeutics-for-rare-genetic-neurodevelopmental-psychiatric-disorders" data-entity-type="node" data-entity-uuid="23285960-4ecb-4a6b-92cf-f74f3cdaa487" data-entity-substitution="canonical">Workshop: Gene-based Therapeutics for Rare Genetic Neurodevelopmental Psychiatric Disorders</a> <br>January 21, 2021</div></div></div><div class="group equal"><div class="col-md-2 col-sm-0 col-xs-0"> </div><div class="col-md-4 col-sm-6 col-xs-12 margin-top-sm"><div class="border-box text-small pad-small"><a href="/news/events/2021/virtual-workshop-integrating-genomics-with-dimensional-and-transdiagnostic-approaches-to-advance-mental-health-research" data-entity-type="node" data-entity-uuid="ee0bd33a-7677-4f6e-bbe1-47246f8df15d" data-entity-substitution="canonical"><em><i class="fas fa-file-video">​</i></em></a> <br><a href="/news/events/2021/virtual-workshop-integrating-genomics-with-dimensional-and-transdiagnostic-approaches-to-advance-mental-health-research" data-entity-type="node" data-entity-uuid="ee0bd33a-7677-4f6e-bbe1-47246f8df15d" data-entity-substitution="canonical">Virtual Workshop: Integrating Genomics with Dimensional and Transdiagnostic Approaches to Advance Mental Health Research</a> <br>April 6, 2021</div></div><div class="col-md-4 col-sm-6 col-xs-12 margin-top-sm"><div class="border-box text-small pad-small"><a href="/news/events/2020/virtual-workshop-genes-to-biology-integrative-systematic-approaches-for-revealing-biological-functions-of-psychiatric-risk-genes-and-alleles" data-entity-type="node" data-entity-uuid="891e6f9a-4d08-4098-bb34-df2451918cda" data-entity-substitution="canonical"><em><i class="fas fa-file-video">​</i></em></a> <br><a href="/news/events/2020/virtual-workshop-genes-to-biology-integrative-systematic-approaches-for-revealing-biological-functions-of-psychiatric-risk-genes-and-alleles" data-entity-type="node" data-entity-uuid="891e6f9a-4d08-4098-bb34-df2451918cda" data-entity-substitution="canonical">Virtual Workshop: Genes to Biology: Integrative Systematic Approaches for Revealing Biological Functions of Psychiatric Risk Genes and Alleles</a> <br>September 22, 2020</div></div><div class="col-md-2 col-sm-0 col-xs-0"> </div></div><h3>Genomics news and events</h3><div class="row"><div class="col-md-4 col-sm-4 col-xs-12 margin-top-sm"><div class="border-box text-small pad-small"><h3 class="mt-3"><a href="/news/science-updates/genetics" data-entity-type="node" data-entity-uuid="16e81c5b-03f1-4cff-927b-5dc31ab19047" data-entity-substitution="canonical"><em><i class="fas fa-bell">​</i></em> </a> <br><a href="/news/science-updates/genetics" data-entity-type="node" data-entity-uuid="16e81c5b-03f1-4cff-927b-5dc31ab19047" data-entity-substitution="canonical">Science News</a></h3><p class="text-small">Find NIMH science news related to genomics research.</p></div></div><div class="col-md-4 col-sm-4 col-xs-12 margin-top-sm"><div class="border-box text-small pad-small"><h3 class="mt-3"><a href="/news/events/genetics-index" data-entity-type="node" data-entity-uuid="e89d57de-c3a4-4a2c-a190-ecc07f88b1bc" data-entity-substitution="canonical"><em><i class="fas fa-calendar-check">​</i></em> </a> <br><a href="/news/events/genetics-index" data-entity-type="node" data-entity-uuid="e89d57de-c3a4-4a2c-a190-ecc07f88b1bc" data-entity-substitution="canonical">Meetings and Events</a></h3><p class="text-small">Discover NIMH workshops and scientific meetings related to genomics research.</p></div></div></div><h3>Team leads</h3><p><strong>Jonathan Pevsner, Ph.D.</strong> <br>Chief, Genomics Research Branch, Division of Neuroscience and Basic Behavioral Science <br><a href="mailto:jonathan.pevsner@nih.gov">jonathan.pevsner@nih.gov</a> <br>301-728-5618</p><p><strong>Doug L. Meinecke, Ph.D.</strong> <br>Program Chief, Molecular and Cellular Pathophysiology Program<br><a href="mailto:dmeineck@mail.nih.gov">dmeineck@nih.gov</a> <br>301-443-6767</p></div>
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