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<div class="c-callout__content c-chief__content">
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<a href="/research/research-labs-and-branches/molecular-immunology-section" hreflang="en">Molecular Immunology Section</a>
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<strong>Research interests:</strong>
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Molecular immunology
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<span class="c-contact__label c-contact__phone">
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301-496-0049
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</span>
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</p>
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<p class="c-contact__label c-contact__address">
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<span>Building 10, Room 10N248G</span>
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<br />
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<span>10 Center Drive</span>
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<br />
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<span>Bethesda, </span>
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<span>
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Maryland
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</span>
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<span>
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20892
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</span>
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</p>
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<div class="c-link c-staff__link">
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<a href="https://irp.nih.gov/pi/charles-egwuagu">View site</a>
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</div>
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<div class="c-section">
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<h2>Biography</h2>
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<div><p>Dr. Charles E. Egwuagu is an Epidemiologist/Immunologist and Chief of the Molecular Immunology Section, National Eye Institute. He received his Ph.D. and M.Phil. from Yale University and an M.P.H from the Yale School of Medicine, New Haven, Connecticut. Dr. Egwuagu then served as a Commissioned Officer of the USA Public Health Service, attaining the rank of Captain (06). Major research focus in the Egwuagu laboratory is on autoreactive lymphocytes that mediate CNS autoimmune diseases, such as Uveitis and Multiple Sclerosis. Particular interest is on cytokine signaling and epigenetic mechanisms that regulate lymphocyte development and cell-fate decisions. The ultimate goal is to develop Biologics and autologous regulatory B cell (Breg) immunotherapy for autoimmune and neurodegenerative diseases.</p></div>
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</div>
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<div class="c-section">
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<h2>Current research</h2>
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<div><p>The Molecular Immunology Section (MIS) seeks an integrated understanding of molecular and cellular mechanisms that regulate host immunity. Particular emphasis is on: (i) mechanisms that regulate lymphocyte development and cell-fate decisions; (ii) identifying and characterizing lymphocyte subsets that mediate or suppress CNS (central nervous system) autoimmune diseases; (iii) developing biologics and cell-based therapies for CNS inflammatory diseases, such as uveitis, multiple sclerosis and age-related macular degeneration (AMD). Use of genetically altered mouse strains and cell types has led to our discovery of novel Regulatory B cell (Breg) populations that suppress inflammation through production of the immune-suppressive cytokines, Interleukin 27 (i27-Breg) or IL-35 (i35-Breg). The long-term goal of our research program is to develop i27-Breg and i35-Breg immunotherapies for the treatment of CNS autoimmune and neurodegenerative diseases and also chronic graft-versus-host disease (GVHD).</p></div>
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</div>
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<div class="c-section">
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<h2>Selected publications</h2>
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<div>
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<div><div class="c-text">
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<p>Amadi-Obi A, Yu CR, Liu X, Mahdi RM, Clarke GL, Nussenblatt RB, Gery I, Lee YS, Egwuagu CE.</p>
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</div>
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</div>
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<div>
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<div class="c-link">
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<a href="https://www.ncbi.nlm.nih.gov/pubmed/17496900" class="c-link__link">TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1.</a>
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</div>
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</div>
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<div><div class="c-text">
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<p>Egwuagu CE, Yu CR.</p>
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</div>
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</div>
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<div>
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<div class="c-link">
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<a href="https://www.ncbi.nlm.nih.gov/pubmed/25746047" class="c-link__link">Interleukin 35-Producing B Cells (i35-Breg): A New Mediator of Regulatory B-Cell Functions in CNS Autoimmune Diseases.</a>
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</div>
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</div>
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<div><div class="c-text">
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<p>He C, Yu CR, Sun L, Mahdi RM, Larkin J 3rd, Egwuagu CE.</p>
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</div>
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</div>
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<div>
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<div class="c-link">
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<a href="https://www.ncbi.nlm.nih.gov/pubmed/26094775" class="c-link__link">Topical administration of a suppressor of cytokine signaling-1 (SOCS1) mimetic peptide inhibits ocular inflammation and mitigates ocular pathology during mouse uveitis.</a>
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</div>
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</div>
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<div><div class="c-text">
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<p>Dambuza IM, He C, Choi JK, Yu CR, Wang R, Mattapallil MJ, Wingfield PT, Caspi RR, Egwuagu CE.</p>
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</div>
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</div>
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<div>
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<div class="c-link">
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<a href="https://www.ncbi.nlm.nih.gov/pubmed/28959012" class="c-link__link">IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease.</a>
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</div>
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</div>
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<div><div class="c-text">
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<p>Wang RX, Yu CR, Dambuza IM, Mahdi RM, Dolinska MB, Sergeev YV, Wingfield PT, Kim SH, Egwuagu CE.</p>
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</div>
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</div>
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<div>
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<div class="c-link">
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<a href="https://www.ncbi.nlm.nih.gov/pubmed/24743305" class="c-link__link">Interleukin-35 induces regulatory B cells that suppress autoimmune disease.</a>
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</div>
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</div>
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</div>
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</div>
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<div class="c-link">
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<a href="https://www.ncbi.nlm.nih.gov/pubmed?term=Egwuagu%20C%5BAuthor%5D">PubMed search for Egwuagu, C.</a>
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</div>
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</div>
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</article>
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</div>
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<p class="views-element-container c-last-updated" id="block-views-block-nei-last-updated-block-1"><strong>Actualización más reciente:</strong> 17 de diciembre de 2024</p>
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