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Updated: February, 2025
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<span class="headername">Database of Clusters of Orthologous Genes (COGs)</span>
<ul data-jig="ncbimenu" id="ui-ncbimenu-1" role="menubar">
<li role="presentation" class="no-submenu">
<a href="/research/cog/" title="Home" class="uppercase" role="menuitem"
id="ui-ncbimenu-1_1">
COG Database
</a>
</li>
<li role="presentation" class="sub-menu">
<a href="#" data-jig="ncbilinksmenu" data-dest-selector="#menu-categories"
class="uppercase">
COG Categories
</a>
<ul style="display:none" id="menu-categories">
<a href="/research/cog/cogcategory/J/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
J - Translation, ribosomal structure and biogenesis</a>
<a href="/research/cog/cogcategory/A/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
A - RNA processing and modification</a>
<a href="/research/cog/cogcategory/K/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
K - Transcription</a>
<a href="/research/cog/cogcategory/L/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
L - Replication, recombination and repair</a>
<a href="/research/cog/cogcategory/B/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
B - Chromatin structure and dynamics</a>
<a href="/research/cog/cogcategory/D/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
D - Cell cycle control, cell division, chromosome partitioning</a>
<a href="/research/cog/cogcategory/Y/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
Y - Nuclear structure</a>
<a href="/research/cog/cogcategory/V/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
V - Defense mechanisms</a>
<a href="/research/cog/cogcategory/T/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
T - Signal transduction mechanisms</a>
<a href="/research/cog/cogcategory/M/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
M - Cell wall/membrane/envelope biogenesis</a>
<a href="/research/cog/cogcategory/N/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
N - Cell motility</a>
<a href="/research/cog/cogcategory/Z/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
Z - Cytoskeleton</a>
<a href="/research/cog/cogcategory/W/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
W - Extracellular structures</a>
<a href="/research/cog/cogcategory/U/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
U - Intracellular trafficking, secretion, and vesicular transport</a>
<a href="/research/cog/cogcategory/O/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
O - Posttranslational modification, protein turnover, chaperones</a>
<a href="/research/cog/cogcategory/X/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
X - nan</a>
<a href="/research/cog/cogcategory/C/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
C - Energy production and conversion</a>
<a href="/research/cog/cogcategory/G/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
G - Carbohydrate transport and metabolism</a>
<a href="/research/cog/cogcategory/E/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
E - Amino acid transport and metabolism</a>
<a href="/research/cog/cogcategory/F/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
F - Nucleotide transport and metabolism</a>
<a href="/research/cog/cogcategory/H/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
H - Coenzyme transport and metabolism</a>
<a href="/research/cog/cogcategory/I/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
I - Lipid transport and metabolism</a>
<a href="/research/cog/cogcategory/P/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
P - Inorganic ion transport and metabolism</a>
<a href="/research/cog/cogcategory/Q/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
Q - Secondary metabolites biosynthesis, transport and catabolism</a>
<a href="/research/cog/cogcategory/R/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
R - General function prediction only</a>
<a href="/research/cog/cogcategory/S/" title="COG Categories"
class="uppercase"
role="menuitem"
style="font-weight: normal;"
id="ui-ncbimenu-1_2">
S - Function unknown</a>
</ul>
</li>
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<a href="/research/cog/pathways/" title="Pathway" class="uppercase"
role="menuitem" tabindex="-1"
id="ui-ncbimenu-1_3">
Pathways
</a>
</li>
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Web Services
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<main id="main_content" accesskey="3">
<section class="usa-section cog_top_section">
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<h1>Web Services</h1>
<h2>COG</h2>
<ol>
<li>Get all COGs:<br>
<b>Web API:</b> <a href="/research/cog/api/cog/" target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/
</a><br>
<b>JSON Format:</b> <a href="/research/cog/api/cog/?format=json" target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?format=json
</a>
</li>
<li>Filter COGs by gene tag: MK0280<br>
<b>Web API:</b> <a href="/research/cog/api/cog/?gene=MK0280" target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?gene=MK0280
</a><br>
<b>JSON Format:</b> <a href="/research/cog/api/cog/?gene=MK0280&format=json"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?gene=MK0280&format=json
</a>
</li>
<li>Filter COGs by COG ID tag: COG0003<br>
<b>Web API:</b> <a href="/research/cog/api/cog/?cog=COG0003" target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?cog=COG0003
</a><br>
<b>JSON Format:</b> <a href="/research/cog/api/cog/?cog=COG0003&format=json"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?cog=COG0003&format=json
</a>
</li>
<li>Filter COGs by assembly ID: GCA_000007185.1<br>
<b>Web API:</b> <a href="/research/cog/api/cog/?assembly=GCA_000007185.1"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?assembly=GCA_000007185.1
</a><br>
<b>JSON Format:</b> <a href="/research/cog/api/cog/?assembly=GCA_000007185.1&format=json"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?assembly=GCA_000007185.1&format=json
</a>
</li>
<li>Filter COGs by organism name: Nitrosopumilus_maritimus_SCM1<br>
<b>Web API:</b> <a href="/research/cog/api/cog/?organism=Nitrosopumilus_maritimus_SCM1"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?organism=Nitrosopumilus_maritimus_SCM1
</a><br>
<b>JSON Format:</b> <a
href="/research/cog/api/cog/?organism=Nitrosopumilus_maritimus_SCM1&format=json"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?organism=Nitrosopumilus_maritimus_SCM11&format=json
</a>
</li>
<li>Filter COGs by taxid: 1229908<br>
<b>Web API:</b> <a href="/research/cog/api/cog/?taxid=1229908"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?taxid=1229908
</a><br>
<b>JSON Format:</b> <a
href="/research/cog/api/cog/?taxid=1229908&format=json"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?taxid=1229908&format=json
</a>
</li>
<li>Filter COGs by Taxonomic Category: ACTINOBACTERIA<br>
<b>Web API:</b> <a href="/research/cog/api/cog/?category=ACTINOBACTERIA"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?category=ACTINOBACTERIA
</a><br>
<b>JSON Format:</b> <a
href="/research/cog/api/cog/?category=ACTINOBACTERIA&format=json"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?category=ACTINOBACTERIA&format=json
</a>
</li>
<li>Filter COGs by Taxonomic Category taxid: 651137<br>
<b>Web API:</b> <a href="/research/cog/api/cog/?cat_taxid=651137"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?cat_taxid=651137
</a><br>
<b>JSON Format:</b> <a
href="/research/cog/api/cog/?cat_taxid=651137&format=json"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?cat_taxid=651137&format=json
</a>
</li>
<li>Filter COGs by Protein name: AJP49128.1<br>
<b>Web API:</b> <a href="/research/cog/api/cog/?protein=AJP49128.1"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?protein=AJP49128.1
</a><br>
<b>JSON Format:</b> <a
href="/research/cog/api/cog/?protein=AJP49128.1&format=json"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?protein=AJP49128.1&format=json
</a>
</li>
</ol>
<h3>COG combined queries</h3>
<p>The search keywords (cog, assembly, organism, taxid, category, cat_taxid and protein) can be combined to
filter the COG lists.</p>
<ol>
<li>Filter COGs by COG id and Taxonomy Categories: COG0004 and CYANOBACTERIA<br>
<b>Web API:</b> <a href="/research/cog/api/cog/?cog=COG0004&category=CYANOBACTERIA"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?cog=COG0004&category=CYANOBACTERIA
</a><br>
<b>JSON Format:</b> <a
href="/research/cog/api/cog/?cog=COG0004&category=CYANOBACTERIA&format=json"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?cog=COG0004&category=CYANOBACTERIA&format=json
</a>
</li>
<li>Filter COGs by COG id and organism: COG0004 and Escherichia_coli_K-12_sub_MG1655<br>
<b>Web API:</b> <a href="/research/cog/api/cog/?cog=COG0004&organism=Escherichia_coli_K-12_sub_MG1655"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?cog=COG0004&organism=Escherichia_coli_K-12_sub_MG1655
</a><br>
<b>JSON Format:</b> <a
href="/research/cog/api/cog/?cog=COG0004&organism=Escherichia_coli_K-12_sub_MG1655&format=json"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cog/?cog=COG0004&organism=Escherichia_coli_K-12_sub_MG1655&format=json
</a>
</li>
</ol>
<h2>COG Definitions</h2>
<ol>
<li>Get all COG Definitions:<br>
<b>Web API:</b> <a href="/research/cog/api/cogdef/" target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cogdef/
</a><br>
<b>JSON Format:</b> <a href="/research/cog/api/cogdef/?format=json" target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cogdef/?format=json
</a>
</li>
<li>Get specific COG Definitions by COG: COG0003<br>
<b>Web API:</b> <a href="/research/cog/api/cogdef/?cog=COG0003" target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cogdef/?cog=COG0003
</a><br>
<b>JSON Format:</b> <a href="/research/cog/api/cogdef/?cog=COG0003&format=json"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cogdef/?cog=COG0003&format=json
</a>
</li>
<li>Get specific COG Definitions by name: Thiamin-binding stress-response protein YqgV, UPF0045
family<br>
<b>Web API:</b> <a
href="/research/cog/api/cogdef/?name=Thiamin-binding%20stress-response%20protein%20YqgV,%20UPF0045%20family"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cogdef/?name=Thiamin-binding%20stress-response%20protein%20YqgV,%20UPF0045%20family
</a><br>
<b>JSON Format:</b> <a
href="/research/cog/api/cogdef/?name=Thiamin-binding%20stress-response%20protein%20YqgV,%20UPF0045%20family&format=json"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/cogdef/?name=Thiamin-binding%20stress-response%20protein%20YqgV,%20UPF0045%20family&format=json
</a>
</li>
</ol>
<h2>Taxonomic Categories</h2>
<ol>
<li>Get all Taxonomic Categories:<br>
<b>Web API:</b> <a href="/research/cog/api/taxonomy/" target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/taxonomy/
</a><br>
<b>JSON Format:</b> <a href="/research/cog/api/taxonomy/?format=json" target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/taxonomy/?format=json
</a>
</li>
<li>Get specific Taxonomic Category by name: ALPHAPROTEOBACTERIA<br>
<b>Web API:</b> <a href="/research/cog/api/taxonomy/?name=ALPHAPROTEOBACTERIA"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/taxonomy/?name=ALPHAPROTEOBACTERIA
</a><br>
<b>JSON Format:</b> <a
href="/research/cog/api/taxonomy/?name=ALPHAPROTEOBACTERIA&format=json"
target="_blank">
https://www.ncbi.nlm.nih.gov/research/cog/api/taxonomy/?name=ALPHAPROTEOBACTERIA&format=json
</a>
</li>
</ol>
</div>
</section>
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