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<ul data-jig="ncbimenu" id="ui-ncbimenu-1" role="menubar">
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J - Translation, ribosomal structure and biogenesis</a>
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A - RNA processing and modification</a>
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K - Transcription</a>
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L - Replication, recombination and repair</a>
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B - Chromatin structure and dynamics</a>
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D - Cell cycle control, cell division, chromosome partitioning</a>
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Y - Nuclear structure</a>
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V - Defense mechanisms</a>
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T - Signal transduction mechanisms</a>
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M - Cell wall/membrane/envelope biogenesis</a>
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N - Cell motility</a>
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Z - Cytoskeleton</a>
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W - Extracellular structures</a>
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U - Intracellular trafficking, secretion, and vesicular transport</a>
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O - Posttranslational modification, protein turnover, chaperones</a>
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X - nan</a>
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C - Energy production and conversion</a>
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G - Carbohydrate transport and metabolism</a>
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E - Amino acid transport and metabolism</a>
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F - Nucleotide transport and metabolism</a>
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H - Coenzyme transport and metabolism</a>
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I - Lipid transport and metabolism</a>
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P - Inorganic ion transport and metabolism</a>
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Q - Secondary metabolites biosynthesis, transport and catabolism</a>
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R - General function prediction only</a>
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S - Function unknown</a>
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COG Project
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<section class="usa-section cog_top_section">
|
||
<div class="usa-grid">
|
||
<p class="index_desc">
|
||
COGs stand for Clusters of Orthologous Genes. The database was initially created in 1997
|
||
(Tatusov et al., PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/9381173/" target="_blank">9381173</a>) followed by
|
||
several updates, most recently in 2024 (Galperin et al., PMID:
|
||
<a href="https://pubmed.ncbi.nlm.nih.gov/39494517/" target="_blank">39494517</a>).
|
||
The current update includes genomes from 2,103 bacterial and 193 archaeal species, of which 2,232
|
||
represent complete genomes in RefSeq and 64 are at the “Chromosome” level. The new features include
|
||
updated COG annotations with corresponding references and PDB links, where available, and >100 new
|
||
COGs for proteins involved in protein secretion pathways and those with unknown functions.
|
||
|
||
The latest COG files with incremental updates can be found in the
|
||
<a href="https://ftp.ncbi.nlm.nih.gov/pub/COG/COG2024/data/" target="_blank">COG2024</a>
|
||
folder on the NCBI's FTP site.
|
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</p>
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<form action="/research/cog/search/" method="get" style="margin-top: 30px;margin-left: 100px;">
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<input id="query" name="query" class="cog_search_bar" type="search"/>
|
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|
||
Search by:<br>
|
||
COG Definition (COG0105 or just the number 105)<br>
|
||
Any word in the COG name (polymerase)<br>
|
||
Taxonomic Category (Mollicutes)<br>
|
||
Organism name (Aciduliprofundum_boonei_T469)<br>
|
||
Pathway (Arginine biosynthesis)<br>
|
||
Assembly (GCA_000091165.1)<br>
|
||
Protein name: (prot:WP_011012300.1)<br>
|
||
Gene Tag: (gene_tag:Haur_1857)<br>
|
||
</div>
|
||
</div>
|
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<div class="table_cell">
|
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<div>
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<img id="searching_icon" class="invisible"
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</div>
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</div>
|
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</form>
|
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<div style="margin-top: 40px;text-align: center;">
|
||
<h2>Statistics</h2>
|
||
<div class="ui-ncbigrid-outer-div organism_cog_table">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table data-jig="ncbigrid">
|
||
<thead>
|
||
<tr>
|
||
<th style="text-align: center;">COGs</th>
|
||
<th style="text-align: center;">Genomic loci</th>
|
||
<th style="text-align: center;">Taxonomic<br>Categories</th>
|
||
<th style="text-align: center;">Organims</th>
|
||
<th style="text-align: center;">Protein IDs</th>
|
||
<th style="text-align: center;">COG symbols</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td>5,050</td>
|
||
<td>6,027,885</td>
|
||
<td>42</td>
|
||
<td>2,296</td>
|
||
<td>5,640,669</td>
|
||
<td>4,094</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
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