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<span class="headername">Database of Clusters of Orthologous Genes (COGs)</span>
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J - Translation, ribosomal structure and biogenesis</a>
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L - Replication, recombination and repair</a>
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B - Chromatin structure and dynamics</a>
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D - Cell cycle control, cell division, chromosome partitioning</a>
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Y - Nuclear structure</a>
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V - Defense mechanisms</a>
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T - Signal transduction mechanisms</a>
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C - Energy production and conversion</a>
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<h1>L<span style='font-weight: 100'> - Replication, recombination and repair</span></h1>
<div style="float: right; clear: both;margin-top: -53px;">
<a class="usa-button" href="#" onclick="download_table_as_tsv('cog_result_table');">Download</a>
</div>
<h2>Stats</h2>
<div style="width: 60%">
<div class="ui-ncbigrid-outer-div organism_cog_table">
<div class="ui-ncbigrid-inner-div">
<table data-jig="ncbigrid">
<thead>
<tr>
<th>COG<br>definitions</th>
<th>Organims</th>
<th>Proteins</th>
<th>Median Protein<br>Length</th>
<th>Genes</th>
</tr>
</thead>
<tbody>
<tr>
<td>202</td>
<td>2,296</td>
<td>258,874</td>
<td>397.0</td>
<td>178</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="ui-ncbigrid-outer-div" style="font-size: 80%;">
<div class="ui-ncbigrid-inner-div">
<table id="cog_result_table" data-jig="ncbigrid">
<thead>
<tr>
<th>Organism</th>
<th>Protein</th>
<th>COG</th>
<th>Cat</th>
<th>Annotation</th>
</tr>
</thead>
<tbody>
<tr>
<td>1330</td>
<td>1835</td>
<td><a href="/research/cog/cog/COG0122/">COG0122</a></td>
<td>
L
</td>
<td>3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase</td>
</tr>
<tr>
<td>2155</td>
<td>2181</td>
<td><a href="/research/cog/cog/COG0164/">COG0164</a></td>
<td>
L
</td>
<td>Ribonuclease HII</td>
</tr>
<tr>
<td>2155</td>
<td>2571</td>
<td><a href="/research/cog/cog/COG0177/">COG0177</a></td>
<td>
L
</td>
<td>Endonuclease III</td>
</tr>
<tr>
<td>2142</td>
<td>3262</td>
<td><a href="/research/cog/cog/COG0178/">COG0178</a></td>
<td>
L
</td>
<td>Excinuclease UvrABC ATPase subunit</td>
</tr>
<tr>
<td>2198</td>
<td>3734</td>
<td><a href="/research/cog/cog/COG0187/">COG0187</a></td>
<td>
L
</td>
<td>DNA gyrase/topoisomerase IV, subunit B</td>
</tr>
<tr>
<td>2195</td>
<td>3774</td>
<td><a href="/research/cog/cog/COG0188/">COG0188</a></td>
<td>
L
</td>
<td>DNA gyrase/topoisomerase IV, subunit A</td>
</tr>
<tr>
<td>2170</td>
<td>5169</td>
<td><a href="/research/cog/cog/COG0210/">COG0210</a></td>
<td>
L
</td>
<td>Superfamily I DNA or RNA helicase</td>
</tr>
<tr>
<td>1816</td>
<td>2536</td>
<td><a href="/research/cog/cog/COG0249/">COG0249</a></td>
<td>
L
</td>
<td>DNA mismatch repair ATPase MutS</td>
</tr>
<tr>
<td>2252</td>
<td>2739</td>
<td><a href="/research/cog/cog/COG0258/">COG0258</a></td>
<td>
L
</td>
<td>5&#x27;-3&#x27; exonuclease Xni/ExoIX (flap endonuclease)</td>
</tr>
<tr>
<td>1637</td>
<td>2446</td>
<td><a href="/research/cog/cog/COG0266/">COG0266</a></td>
<td>
L
</td>
<td>Formamidopyrimidine-DNA glycosylase</td>
</tr>
<tr>
<td>1164</td>
<td>2268</td>
<td><a href="/research/cog/cog/COG0270/">COG0270</a></td>
<td>
J
L
</td>
<td>DNA-cytosine methylase Dcm or eukaryotic tRNA-C38 C5-methylase, Dcm/DNMT2/TRDMT1 family</td>
</tr>
<tr>
<td>2102</td>
<td>2441</td>
<td><a href="/research/cog/cog/COG0272/">COG0272</a></td>
<td>
L
</td>
<td>NAD-dependent DNA ligase</td>
</tr>
<tr>
<td>2083</td>
<td>2652</td>
<td><a href="/research/cog/cog/COG0305/">COG0305</a></td>
<td>
L
</td>
<td>Replicative DNA helicase</td>
</tr>
<tr>
<td>2133</td>
<td>2758</td>
<td><a href="/research/cog/cog/COG0322/">COG0322</a></td>
<td>
L
</td>
<td>Excinuclease UvrABC, nuclease subunit</td>
</tr>
<tr>
<td>1833</td>
<td>1997</td>
<td><a href="/research/cog/cog/COG0323/">COG0323</a></td>
<td>
L
</td>
<td>DNA mismatch repair ATPase MutL</td>
</tr>
<tr>
<td>1882</td>
<td>2267</td>
<td><a href="/research/cog/cog/COG0328/">COG0328</a></td>
<td>
L
</td>
<td>Ribonuclease HI</td>
</tr>
<tr>
<td>791</td>
<td>1185</td>
<td><a href="/research/cog/cog/COG0338/">COG0338</a></td>
<td>
L
</td>
<td>DNA-adenine methylase</td>
</tr>
<tr>
<td>2059</td>
<td>3018</td>
<td><a href="/research/cog/cog/COG0350/">COG0350</a></td>
<td>
L
</td>
<td>DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase)</td>
</tr>
<tr>
<td>2003</td>
<td>2004</td>
<td><a href="/research/cog/cog/COG0353/">COG0353</a></td>
<td>
L
</td>
<td>Recombinational DNA repair protein RecR</td>
</tr>
<tr>
<td>2260</td>
<td>3065</td>
<td><a href="/research/cog/cog/COG0358/">COG0358</a></td>
<td>
L
</td>
<td>DNA primase (bacterial type)</td>
</tr>
<tr>
<td>1891</td>
<td>3632</td>
<td><a href="/research/cog/cog/COG0389/">COG0389</a></td>
<td>
L
</td>
<td>Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair</td>
</tr>
<tr>
<td>1357</td>
<td>1912</td>
<td><a href="/research/cog/cog/COG0415/">COG0415</a></td>
<td>
L
</td>
<td>Deoxyribodipyrimidine photolyase</td>
</tr>
<tr>
<td>507</td>
<td>687</td>
<td><a href="/research/cog/cog/COG0417/">COG0417</a></td>
<td>
L
</td>
<td>DNA polymerase B elongation subunit</td>
</tr>
<tr>
<td>1469</td>
<td>2174</td>
<td><a href="/research/cog/cog/COG0419/">COG0419</a></td>
<td>
L
</td>
<td>DNA repair exonuclease SbcCD ATPase subunit</td>
</tr>
<tr>
<td>1562</td>
<td>2130</td>
<td><a href="/research/cog/cog/COG0420/">COG0420</a></td>
<td>
L
</td>
<td>DNA repair exonuclease SbcCD nuclease subunit</td>
</tr>
<tr>
<td>1371</td>
<td>2265</td>
<td><a href="/research/cog/cog/COG0433/">COG0433</a></td>
<td>
L
</td>
<td>Crenarchaeal DNA import helicase CedB/HerA or a related bacterial ATPase</td>
</tr>
<tr>
<td>2237</td>
<td>2554</td>
<td><a href="/research/cog/cog/COG0468/">COG0468</a></td>
<td>
L
</td>
<td>RecA/RadA recombinase</td>
</tr>
<tr>
<td>1112</td>
<td>1312</td>
<td><a href="/research/cog/cog/COG0470/">COG0470</a></td>
<td>
L
</td>
<td>DNA polymerase III, delta prime subunit</td>
</tr>
<tr>
<td>1969</td>
<td>7381</td>
<td><a href="/research/cog/cog/COG0488/">COG0488</a></td>
<td>
J
L
</td>
<td>ABC cassette proteins with duplicated ATPase domains, Uup/ABCF family</td>
</tr>
<tr>
<td>1523</td>
<td>1736</td>
<td><a href="/research/cog/cog/COG0496/">COG0496</a></td>
<td>
L
</td>
<td>Broad specificity polyphosphatase and 5&#x27;/3&#x27;-nucleotidase SurE</td>
</tr>
<tr>
<td>1916</td>
<td>1986</td>
<td><a href="/research/cog/cog/COG0497/">COG0497</a></td>
<td>
L
</td>
<td>DNA repair ATPase RecN</td>
</tr>
<tr>
<td>1567</td>
<td>2562</td>
<td><a href="/research/cog/cog/COG0507/">COG0507</a></td>
<td>
L
</td>
<td>ATPase/5&#x27;-3&#x27; helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V)</td>
</tr>
<tr>
<td>2060</td>
<td>6519</td>
<td><a href="/research/cog/cog/COG0513/">COG0513</a></td>
<td>
L
</td>
<td>Superfamily II DNA and RNA helicase</td>
</tr>
<tr>
<td>1634</td>
<td>2798</td>
<td><a href="/research/cog/cog/COG0514/">COG0514</a></td>
<td>
L
</td>
<td>Superfamily II DNA helicase RecQ</td>
</tr>
<tr>
<td>2042</td>
<td>2043</td>
<td><a href="/research/cog/cog/COG0536/">COG0536</a></td>
<td>
L
D
</td>
<td>GTPase involved in cell partioning and DNA repair</td>
</tr>
<tr>
<td>2235</td>
<td>3258</td>
<td><a href="/research/cog/cog/COG0550/">COG0550</a></td>
<td>
L
</td>
<td>DNA topoisomerase IA</td>
</tr>
<tr>
<td>1145</td>
<td>1620</td>
<td><a href="/research/cog/cog/COG0551/">COG0551</a></td>
<td>
L
</td>
<td>DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains</td>
</tr>
<tr>
<td>1491</td>
<td>3044</td>
<td><a href="/research/cog/cog/COG0553/">COG0553</a></td>
<td>
K
L
</td>
<td>Superfamily II DNA or RNA helicase, SNF2 family</td>
</tr>
<tr>
<td>2124</td>
<td>2145</td>
<td><a href="/research/cog/cog/COG0556/">COG0556</a></td>
<td>
L
</td>
<td>Excinuclease UvrABC helicase subunit UvrB</td>
</tr>
<tr>
<td>794</td>
<td>1619</td>
<td><a href="/research/cog/cog/COG0582/">COG0582</a></td>
<td>
L
X
</td>
<td>Integrase/recombinase, includes phage integrase</td>
</tr>
<tr>
<td>2078</td>
<td>3192</td>
<td><a href="/research/cog/cog/COG0587/">COG0587</a></td>
<td>
L
</td>
<td>DNA polymerase III, alpha subunit</td>
</tr>
<tr>
<td>2275</td>
<td>2576</td>
<td><a href="/research/cog/cog/COG0592/">COG0592</a></td>
<td>
L
</td>
<td>DNA polymerase III sliding clamp (beta) subunit, PCNA homolog</td>
</tr>
<tr>
<td>2041</td>
<td>3073</td>
<td><a href="/research/cog/cog/COG0593/">COG0593</a></td>
<td>
L
</td>
<td>Chromosomal replication initiation ATPase DnaA</td>
</tr>
<tr>
<td>1955</td>
<td>2199</td>
<td><a href="/research/cog/cog/COG0608/">COG0608</a></td>
<td>
L
</td>
<td>ssDNA-specific exonuclease RecJ, DHH superfamily, may be involved in archaeal DNA replication intiation</td>
</tr>
<tr>
<td>2076</td>
<td>3739</td>
<td><a href="/research/cog/cog/COG0629/">COG0629</a></td>
<td>
L
</td>
<td>Single-stranded DNA-binding protein</td>
</tr>
<tr>
<td>2043</td>
<td>2047</td>
<td><a href="/research/cog/cog/COG0632/">COG0632</a></td>
<td>
L
</td>
<td>Holliday junction resolvasome RuvABC DNA-binding subunit</td>
</tr>
<tr>
<td>1050</td>
<td>1161</td>
<td><a href="/research/cog/cog/COG0648/">COG0648</a></td>
<td>
L
</td>
<td>Endonuclease IV</td>
</tr>
<tr>
<td>1289</td>
<td>1331</td>
<td><a href="/research/cog/cog/COG0692/">COG0692</a></td>
<td>
L
</td>
<td>Uracil-DNA glycosylase</td>
</tr>
<tr>
<td>11</td>
<td>12</td>
<td><a href="/research/cog/cog/COG0699/">COG0699</a></td>
<td>
L
</td>
<td>Replication fork clamp-binding protein CrfC (dynamin-like GTPase family)</td>
</tr>
<tr>
<td>1868</td>
<td>2906</td>
<td><a href="/research/cog/cog/COG0708/">COG0708</a></td>
<td>
L
</td>
<td>Exonuclease III</td>
</tr>
<tr>
<td>2000</td>
<td>2350</td>
<td><a href="/research/cog/cog/COG0749/">COG0749</a></td>
<td>
L
</td>
<td>DNA polymerase I, 3&#x27;-5&#x27; exonuclease and polymerase domains</td>
</tr>
<tr>
<td>1981</td>
<td>2266</td>
<td><a href="/research/cog/cog/COG0758/">COG0758</a></td>
<td>
L
</td>
<td>Predicted Rossmann fold nucleotide-binding protein DprA/Smf involved in DNA uptake</td>
</tr>
<tr>
<td>1805</td>
<td>1824</td>
<td><a href="/research/cog/cog/COG0792/">COG0792</a></td>
<td>
L
</td>
<td>Predicted endonuclease distantly related to archaeal Holliday junction resolvase, YraN/UPF0102 family</td>
</tr>
<tr>
<td>1983</td>
<td>2075</td>
<td><a href="/research/cog/cog/COG0816/">COG0816</a></td>
<td>
J
K
L
</td>
<td>YqgF/RuvX protein, pre-16S rRNA maturation RNase/Holliday junction resolvase/anti-termination factor</td>
</tr>
<tr>
<td>1826</td>
<td>1878</td>
<td><a href="/research/cog/cog/COG0817/">COG0817</a></td>
<td>
L
</td>
<td>Holliday junction resolvasome RuvABC endonuclease subunit RuvC</td>
</tr>
<tr>
<td>222</td>
<td>237</td>
<td><a href="/research/cog/cog/COG0827/">COG0827</a></td>
<td>
L
</td>
<td>Adenine-specific DNA N6-methylase</td>
</tr>
<tr>
<td>1641</td>
<td>3355</td>
<td><a href="/research/cog/cog/COG0847/">COG0847</a></td>
<td>
L
</td>
<td>DNA polymerase III, epsilon subunit or related 3&#x27;-5&#x27; exonuclease</td>
</tr>
<tr>
<td>1139</td>
<td>2359</td>
<td><a href="/research/cog/cog/COG0863/">COG0863</a></td>
<td>
L
V
</td>
<td>DNA modification adenine methylase</td>
</tr>
<tr>
<td>201</td>
<td>205</td>
<td><a href="/research/cog/cog/COG1039/">COG1039</a></td>
<td>
L
</td>
<td>Ribonuclease HIII</td>
</tr>
<tr>
<td>1537</td>
<td>1642</td>
<td><a href="/research/cog/cog/COG1058/">COG1058</a></td>
<td>
L
</td>
<td>ADP-ribose pyrophosphatase domain of DNA damage- and competence-inducible protein CinA</td>
</tr>
<tr>
<td>84</td>
<td>85</td>
<td><a href="/research/cog/cog/COG1059/">COG1059</a></td>
<td>
L
V
</td>
<td>Thermostable 8-oxoguanine DNA glycosylase</td>
</tr>
<tr>
<td>1435</td>
<td>2810</td>
<td><a href="/research/cog/cog/COG1061/">COG1061</a></td>
<td>
K
L
</td>
<td>Superfamily II DNA or RNA helicase</td>
</tr>
<tr>
<td>1877</td>
<td>1943</td>
<td><a href="/research/cog/cog/COG1066/">COG1066</a></td>
<td>
L
</td>
<td>DNA repair protein RadA/Sms, contains AAA+ ATPase domain</td>
</tr>
<tr>
<td>1835</td>
<td>2127</td>
<td><a href="/research/cog/cog/COG1074/">COG1074</a></td>
<td>
L
</td>
<td>3&#x27;-5&#x27; helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V)</td>
</tr>
<tr>
<td>116</td>
<td>176</td>
<td><a href="/research/cog/cog/COG1107/">COG1107</a></td>
<td>
L
</td>
<td>Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain</td>
</tr>
<tr>
<td>78</td>
<td>103</td>
<td><a href="/research/cog/cog/COG1110/">COG1110</a></td>
<td>
L
</td>
<td>Reverse gyrase</td>
</tr>
<tr>
<td>229</td>
<td>249</td>
<td><a href="/research/cog/cog/COG1111/">COG1111</a></td>
<td>
L
</td>
<td>ERCC4-related helicase</td>
</tr>
<tr>
<td>943</td>
<td>1431</td>
<td><a href="/research/cog/cog/COG1112/">COG1112</a></td>
<td>
L
</td>
<td>Superfamily I DNA and/or RNA helicase</td>
</tr>
<tr>
<td>1798</td>
<td>1836</td>
<td><a href="/research/cog/cog/COG1194/">COG1194</a></td>
<td>
L
</td>
<td>Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs</td>
</tr>
<tr>
<td>1696</td>
<td>1772</td>
<td><a href="/research/cog/cog/COG1195/">COG1195</a></td>
<td>
L
</td>
<td>Recombinational DNA repair ATPase RecF</td>
</tr>
<tr>
<td>1975</td>
<td>2011</td>
<td><a href="/research/cog/cog/COG1197/">COG1197</a></td>
<td>
K
L
</td>
<td>Transcription-repair coupling factor (superfamily II helicase)</td>
</tr>
<tr>
<td>2030</td>
<td>2052</td>
<td><a href="/research/cog/cog/COG1198/">COG1198</a></td>
<td>
L
</td>
<td>Primosomal protein N&#x27; (replication factor Y) - superfamily II helicase</td>
</tr>
<tr>
<td>1492</td>
<td>2038</td>
<td><a href="/research/cog/cog/COG1199/">COG1199</a></td>
<td>
L
</td>
<td>Rad3-related DNA helicase DinG</td>
</tr>
<tr>
<td>1910</td>
<td>1951</td>
<td><a href="/research/cog/cog/COG1200/">COG1200</a></td>
<td>
L
</td>
<td>RecG-like helicase</td>
</tr>
<tr>
<td>969</td>
<td>1265</td>
<td><a href="/research/cog/cog/COG1201/">COG1201</a></td>
<td>
L
</td>
<td>Lhr-like helicase</td>
</tr>
<tr>
<td>110</td>
<td>178</td>
<td><a href="/research/cog/cog/COG1202/">COG1202</a></td>
<td>
L
</td>
<td>Superfamily II helicase, archaea-specific</td>
</tr>
<tr>
<td>456</td>
<td>596</td>
<td><a href="/research/cog/cog/COG1204/">COG1204</a></td>
<td>
L
</td>
<td>Replicative superfamily II helicase</td>
</tr>
<tr>
<td>765</td>
<td>1058</td>
<td><a href="/research/cog/cog/COG1205/">COG1205</a></td>
<td>
L
</td>
<td>ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain</td>
</tr>
<tr>
<td>193</td>
<td>258</td>
<td><a href="/research/cog/cog/COG1241/">COG1241</a></td>
<td>
L
</td>
<td>DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family</td>
</tr>
<tr>
<td>581</td>
<td>721</td>
<td><a href="/research/cog/cog/COG1273/">COG1273</a></td>
<td>
L
</td>
<td>Non-homologous end joining protein Ku, dsDNA break repair</td>
</tr>
<tr>
<td>160</td>
<td>161</td>
<td><a href="/research/cog/cog/COG1311/">COG1311</a></td>
<td>
L
</td>
<td>Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B</td>
</tr>
<tr>
<td>1381</td>
<td>1412</td>
<td><a href="/research/cog/cog/COG1322/">COG1322</a></td>
<td>
L
</td>
<td>DNA anti-recombination protein (rearrangement mutator) RmuC</td>
</tr>
<tr>
<td>486</td>
<td>491</td>
<td><a href="/research/cog/cog/COG1330/">COG1330</a></td>
<td>
L
</td>
<td>Scaffold subunit RecC of the DNA repair enzyme RecBCD (exonuclease V)</td>
</tr>
<tr>
<td>1703</td>
<td>1723</td>
<td><a href="/research/cog/cog/COG1354/">COG1354</a></td>
<td>
L
</td>
<td>Chromatin segregation and condensation protein Rec8/ScpA/Scc1, kleisin family</td>
</tr>
<tr>
<td>305</td>
<td>536</td>
<td><a href="/research/cog/cog/COG1372/">COG1372</a></td>
<td>
L
X
</td>
<td>Intein/homing endonuclease, contains LAGLIDADG-like domain</td>
</tr>
<tr>
<td>1948</td>
<td>1951</td>
<td><a href="/research/cog/cog/COG1381/">COG1381</a></td>
<td>
L
</td>
<td>Recombinational DNA repair protein RecO (RecF pathway)</td>
</tr>
<tr>
<td>207</td>
<td>217</td>
<td><a href="/research/cog/cog/COG1389/">COG1389</a></td>
<td>
L
</td>
<td>DNA topoisomerase VI, subunit B</td>
</tr>
<tr>
<td>110</td>
<td>110</td>
<td><a href="/research/cog/cog/COG1423/">COG1423</a></td>
<td>
L
</td>
<td>ATP-dependent RNA circularization protein, DNA/RNA ligase (PAB1020) family</td>
</tr>
<tr>
<td>2048</td>
<td>2079</td>
<td><a href="/research/cog/cog/COG1466/">COG1466</a></td>
<td>
L
</td>
<td>DNA polymerase III, delta subunit</td>
</tr>
<tr>
<td>183</td>
<td>212</td>
<td><a href="/research/cog/cog/COG1467/">COG1467</a></td>
<td>
L
</td>
<td>Eukaryotic-type DNA primase, small subunit</td>
</tr>
<tr>
<td>308</td>
<td>987</td>
<td><a href="/research/cog/cog/COG1474/">COG1474</a></td>
<td>
L
</td>
<td>Cdc6-related protein, AAA superfamily ATPase</td>
</tr>
<tr>
<td>1015</td>
<td>2499</td>
<td><a href="/research/cog/cog/COG1484/">COG1484</a></td>
<td>
L
</td>
<td>DNA replication protein DnaC</td>
</tr>
<tr>
<td>565</td>
<td>581</td>
<td><a href="/research/cog/cog/COG1515/">COG1515</a></td>
<td>
L
</td>
<td>Deoxyinosine 3&#x27;-endonuclease (endonuclease V)</td>
</tr>
<tr>
<td>1067</td>
<td>1749</td>
<td><a href="/research/cog/cog/COG1525/">COG1525</a></td>
<td>
L
</td>
<td>Endonuclease YncB, thermonuclease family</td>
</tr>
<tr>
<td>1143</td>
<td>1470</td>
<td><a href="/research/cog/cog/COG1533/">COG1533</a></td>
<td>
L
</td>
<td>DNA thymine dimer repair photolyase</td>
</tr>
<tr>
<td>1517</td>
<td>1825</td>
<td><a href="/research/cog/cog/COG1555/">COG1555</a></td>
<td>
L
</td>
<td>DNA uptake protein ComE or related DNA-binding protein</td>
</tr>
<tr>
<td>1854</td>
<td>1885</td>
<td><a href="/research/cog/cog/COG1570/">COG1570</a></td>
<td>
L
</td>
<td>Exonuclease VII, large subunit</td>
</tr>
<tr>
<td>1593</td>
<td>2727</td>
<td><a href="/research/cog/cog/COG1573/">COG1573</a></td>
<td>
L
</td>
<td>Uracil-DNA glycosylase</td>
</tr>
<tr>
<td>151</td>
<td>164</td>
<td><a href="/research/cog/cog/COG1591/">COG1591</a></td>
<td>
L
</td>
<td>Holliday junction resolvase Hjc, archaeal type</td>
</tr>
<tr>
<td>184</td>
<td>422</td>
<td><a href="/research/cog/cog/COG1599/">COG1599</a></td>
<td>
L
</td>
<td>ssDNA-binding replication factor A, large subunit</td>
</tr>
<tr>
<td>181</td>
<td>199</td>
<td><a href="/research/cog/cog/COG1602/">COG1602</a></td>
<td>
L
</td>
<td>Archaeal DNA repair protein NreA</td>
</tr>
<tr>
<td>46</td>
<td>47</td>
<td><a href="/research/cog/cog/COG1630/">COG1630</a></td>
<td>
L
</td>
<td>ssDNA and dsDNA 5&#x27;-3&#x27; nuclease NurA, repair of double-stranded DNA breaks</td>
</tr>
<tr>
<td>456</td>
<td>555</td>
<td><a href="/research/cog/cog/COG1637/">COG1637</a></td>
<td>
L
</td>
<td>Endonuclease NucS, RecB family</td>
</tr>
<tr>
<td>219</td>
<td>226</td>
<td><a href="/research/cog/cog/COG1697/">COG1697</a></td>
<td>
L
</td>
<td>DNA topoisomerase VI, subunit A</td>
</tr>
<tr>
<td>140</td>
<td>147</td>
<td><a href="/research/cog/cog/COG1711/">COG1711</a></td>
<td>
L
</td>
<td>DNA replication initiation complex subunit, GINS family</td>
</tr>
<tr>
<td>1729</td>
<td>1737</td>
<td><a href="/research/cog/cog/COG1722/">COG1722</a></td>
<td>
L
</td>
<td>Exonuclease VII small subunit</td>
</tr>
<tr>
<td>294</td>
<td>406</td>
<td><a href="/research/cog/cog/COG1743/">COG1743</a></td>
<td>
L
</td>
<td>Adenine-specific DNA methylase, contains a Zn-ribbon domain</td>
</tr>
<tr>
<td>1113</td>
<td>1905</td>
<td><a href="/research/cog/cog/COG1793/">COG1793</a></td>
<td>
L
</td>
<td>ATP-dependent DNA ligase</td>
</tr>
<tr>
<td>563</td>
<td>617</td>
<td><a href="/research/cog/cog/COG1796/">COG1796</a></td>
<td>
L
</td>
<td>DNA polymerase/3&#x27;-5&#x27; exonuclease PolX</td>
</tr>
<tr>
<td>130</td>
<td>131</td>
<td><a href="/research/cog/cog/COG1860/">COG1860</a></td>
<td>
L
F
</td>
<td>Predicted metal-binding protein, contains two cysteine clusters, UPF0179 family</td>
</tr>
<tr>
<td>160</td>
<td>160</td>
<td><a href="/research/cog/cog/COG1933/">COG1933</a></td>
<td>
L
</td>
<td>Archaeal DNA polymerase II, large subunit</td>
</tr>
<tr>
<td>216</td>
<td>257</td>
<td><a href="/research/cog/cog/COG1948/">COG1948</a></td>
<td>
L
</td>
<td>ERCC4-type crossover junction endonuclease</td>
</tr>
<tr>
<td>1397</td>
<td>4556</td>
<td><a href="/research/cog/cog/COG1961/">COG1961</a></td>
<td>
L
</td>
<td>Site-specific DNA recombinase SpoIVCA/DNA invertase PinE</td>
</tr>
<tr>
<td>1651</td>
<td>2258</td>
<td><a href="/research/cog/cog/COG2003/">COG2003</a></td>
<td>
L
</td>
<td>DNA repair protein RadC, contains a helix-hairpin-helix DNA-binding motif</td>
</tr>
<tr>
<td>725</td>
<td>732</td>
<td><a href="/research/cog/cog/COG2094/">COG2094</a></td>
<td>
L
</td>
<td>3-methyladenine DNA glycosylase Mpg</td>
</tr>
<tr>
<td>1126</td>
<td>1495</td>
<td><a href="/research/cog/cog/COG2135/">COG2135</a></td>
<td>
L
</td>
<td>ssDNA abasic site-binding protein YedK/HMCES, SRAP family</td>
</tr>
<tr>
<td>829</td>
<td>1005</td>
<td><a href="/research/cog/cog/COG2169/">COG2169</a></td>
<td>
L
</td>
<td>Methylphosphotriester-DNA--protein-cysteine methyltransferase, contains Zn-binding and AraC-type DNA-binding domains</td>
</tr>
<tr>
<td>994</td>
<td>1450</td>
<td><a href="/research/cog/cog/COG2176/">COG2176</a></td>
<td>
L
</td>
<td>DNA polymerase III, alpha subunit (gram-positive type)</td>
</tr>
<tr>
<td>668</td>
<td>910</td>
<td><a href="/research/cog/cog/COG2189/">COG2189</a></td>
<td>
L
</td>
<td>Adenine specific DNA methylase Mod</td>
</tr>
<tr>
<td>185</td>
<td>192</td>
<td><a href="/research/cog/cog/COG2219/">COG2219</a></td>
<td>
L
</td>
<td>Eukaryotic-type DNA primase, large subunit</td>
</tr>
<tr>
<td>294</td>
<td>296</td>
<td><a href="/research/cog/cog/COG2231/">COG2231</a></td>
<td>
L
</td>
<td>3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily</td>
</tr>
<tr>
<td>2035</td>
<td>2087</td>
<td><a href="/research/cog/cog/COG2255/">COG2255</a></td>
<td>
L
</td>
<td>Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB</td>
</tr>
<tr>
<td>1958</td>
<td>2084</td>
<td><a href="/research/cog/cog/COG2256/">COG2256</a></td>
<td>
L
</td>
<td>Replication-associated recombination protein RarA (DNA-dependent ATPase)</td>
</tr>
<tr>
<td>560</td>
<td>561</td>
<td><a href="/research/cog/cog/COG2354/">COG2354</a></td>
<td>
L
</td>
<td>Membrane protein MutK/YedI, may be involved in DNA repair</td>
</tr>
<tr>
<td>386</td>
<td>552</td>
<td><a href="/research/cog/cog/COG2356/">COG2356</a></td>
<td>
L
</td>
<td>Endonuclease I</td>
</tr>
<tr>
<td>145</td>
<td>173</td>
<td><a href="/research/cog/cog/COG2406/">COG2406</a></td>
<td>
L
</td>
<td>Ferritin-like DNA-binding protein, DPS (DNA Protection under Starvation) family</td>
</tr>
<tr>
<td>2098</td>
<td>3267</td>
<td><a href="/research/cog/cog/COG2812/">COG2812</a></td>
<td>
L
</td>
<td>DNA polymerase III, gamma/tau subunits</td>
</tr>
<tr>
<td>1261</td>
<td>1458</td>
<td><a href="/research/cog/cog/COG2818/">COG2818</a></td>
<td>
L
</td>
<td>3-methyladenine DNA glycosylase Tag</td>
</tr>
<tr>
<td>1121</td>
<td>1770</td>
<td><a href="/research/cog/cog/COG2827/">COG2827</a></td>
<td>
L
</td>
<td>Predicted endonuclease, GIY-YIG superfamily</td>
</tr>
<tr>
<td>850</td>
<td>953</td>
<td><a href="/research/cog/cog/COG2840/">COG2840</a></td>
<td>
J
L
</td>
<td>Stalled ribosome-rescuing mRNA endonuclease or DNA-nicking endonuclease, Smr domain</td>
</tr>
<tr>
<td>735</td>
<td>1324</td>
<td><a href="/research/cog/cog/COG2852/">COG2852</a></td>
<td>
L
</td>
<td>Very-short-patch-repair endonuclease</td>
</tr>
<tr>
<td>824</td>
<td>1122</td>
<td><a href="/research/cog/cog/COG2887/">COG2887</a></td>
<td>
L
</td>
<td>RecB family exonuclease</td>
</tr>
<tr>
<td>388</td>
<td>395</td>
<td><a href="/research/cog/cog/COG2925/">COG2925</a></td>
<td>
L
</td>
<td>Exonuclease I (degrades ssDNA)</td>
</tr>
<tr>
<td>766</td>
<td>767</td>
<td><a href="/research/cog/cog/COG2927/">COG2927</a></td>
<td>
L
</td>
<td>DNA polymerase III, chi subunit</td>
</tr>
<tr>
<td>78</td>
<td>126</td>
<td><a href="/research/cog/cog/COG2946/">COG2946</a></td>
<td>
L
</td>
<td>DNA relaxase NicK</td>
</tr>
<tr>
<td>287</td>
<td>287</td>
<td><a href="/research/cog/cog/COG2965/">COG2965</a></td>
<td>
L
</td>
<td>Primosomal replication protein N</td>
</tr>
<tr>
<td>417</td>
<td>465</td>
<td><a href="/research/cog/cog/COG2974/">COG2974</a></td>
<td>
L
</td>
<td>DNA recombination-dependent growth factor RdgC</td>
</tr>
<tr>
<td>990</td>
<td>1005</td>
<td><a href="/research/cog/cog/COG3022/">COG3022</a></td>
<td>
L
</td>
<td>DNA-binding protein YaaA associated with the oxidative stress response</td>
</tr>
<tr>
<td>752</td>
<td>752</td>
<td><a href="/research/cog/cog/COG3024/">COG3024</a></td>
<td>
L
</td>
<td>Endogenous inhibitor of DNA gyrase, YacG/DUF329 family</td>
</tr>
<tr>
<td>108</td>
<td>108</td>
<td><a href="/research/cog/cog/COG3050/">COG3050</a></td>
<td>
L
</td>
<td>DNA polymerase III, psi subunit</td>
</tr>
<tr>
<td>131</td>
<td>131</td>
<td><a href="/research/cog/cog/COG3057/">COG3057</a></td>
<td>
L
</td>
<td>Negative regulator of replication initiation SeqA</td>
</tr>
<tr>
<td>192</td>
<td>194</td>
<td><a href="/research/cog/cog/COG3066/">COG3066</a></td>
<td>
L
</td>
<td>DNA mismatch repair protein MutH</td>
</tr>
<tr>
<td>207</td>
<td>215</td>
<td><a href="/research/cog/cog/COG3081/">COG3081</a></td>
<td>
L
</td>
<td>dsDNA-binding nucleoid-associated protein YejK/NdpA</td>
</tr>
<tr>
<td>96</td>
<td>97</td>
<td><a href="/research/cog/cog/COG3120/">COG3120</a></td>
<td>
L
</td>
<td>Macrodomain Ter protein organizer, MatP/YcbG family</td>
</tr>
<tr>
<td>126</td>
<td>130</td>
<td><a href="/research/cog/cog/COG3141/">COG3141</a></td>
<td>
L
</td>
<td>dsDNA-binding SOS-regulon protein YebG, induction by DNA damage requires cAMP</td>
</tr>
<tr>
<td>780</td>
<td>907</td>
<td><a href="/research/cog/cog/COG3145/">COG3145</a></td>
<td>
L
</td>
<td>Alkylated DNA repair dioxygenase AlkB</td>
</tr>
<tr>
<td>525</td>
<td>571</td>
<td><a href="/research/cog/cog/COG3214/">COG3214</a></td>
<td>
L
</td>
<td>DNA glycosylase YcaQ, repair of DNA interstrand crosslinks</td>
</tr>
<tr>
<td>589</td>
<td>951</td>
<td><a href="/research/cog/cog/COG3285/">COG3285</a></td>
<td>
L
</td>
<td>DNA ligase D, polymerase domain, archaeal/eukaryal DNA primase (AEP) superfamily</td>
</tr>
<tr>
<td>137</td>
<td>138</td>
<td><a href="/research/cog/cog/COG3298/">COG3298</a></td>
<td>
L
</td>
<td>Predicted 3&#x27;-5&#x27; exonuclease related to the exonuclease domain of PolB</td>
</tr>
<tr>
<td>125</td>
<td>229</td>
<td><a href="/research/cog/cog/COG3390/">COG3390</a></td>
<td>
L
</td>
<td>Replication protein A (RPA) family protein</td>
</tr>
<tr>
<td>169</td>
<td>194</td>
<td><a href="/research/cog/cog/COG3392/">COG3392</a></td>
<td>
L
</td>
<td>Adenine-specific DNA methylase</td>
</tr>
<tr>
<td>409</td>
<td>542</td>
<td><a href="/research/cog/cog/COG3449/">COG3449</a></td>
<td>
L
</td>
<td>DNA gyrase inhibitor GyrI/SbmC</td>
</tr>
<tr>
<td>424</td>
<td>434</td>
<td><a href="/research/cog/cog/COG3569/">COG3569</a></td>
<td>
L
</td>
<td>DNA topoisomerase IB</td>
</tr>
<tr>
<td>782</td>
<td>1064</td>
<td><a href="/research/cog/cog/COG3593/">COG3593</a></td>
<td>
L
</td>
<td>Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM domains</td>
</tr>
<tr>
<td>370</td>
<td>506</td>
<td><a href="/research/cog/cog/COG3598/">COG3598</a></td>
<td>
L
</td>
<td>RecA-family ATPase</td>
</tr>
<tr>
<td>187</td>
<td>195</td>
<td><a href="/research/cog/cog/COG3611/">COG3611</a></td>
<td>
L
</td>
<td>Replication initiation and membrane attachment protein DnaB</td>
</tr>
<tr>
<td>699</td>
<td>720</td>
<td><a href="/research/cog/cog/COG3663/">COG3663</a></td>
<td>
L
</td>
<td>G:T/U-mismatch repair DNA glycosylase</td>
</tr>
<tr>
<td>140</td>
<td>160</td>
<td><a href="/research/cog/cog/COG3723/">COG3723</a></td>
<td>
L
</td>
<td>Recombinational DNA repair protein RecT</td>
</tr>
<tr>
<td>509</td>
<td>570</td>
<td><a href="/research/cog/cog/COG3727/">COG3727</a></td>
<td>
L
</td>
<td>G:T-mismatch repair DNA endonuclease Vsr, very short patch repair protein</td>
</tr>
<tr>
<td>390</td>
<td>729</td>
<td><a href="/research/cog/cog/COG3743/">COG3743</a></td>
<td>
L
</td>
<td>Predicted 5&#x27; DNA nuclease, flap endonuclease-1-like, helix-3-turn-helix (H3TH) domain</td>
</tr>
<tr>
<td>7</td>
<td>9</td>
<td><a href="/research/cog/cog/COG3780/">COG3780</a></td>
<td>
L
</td>
<td>DNA endonuclease related to intein-encoded endonucleases</td>
</tr>
<tr>
<td>161</td>
<td>175</td>
<td><a href="/research/cog/cog/COG3826/">COG3826</a></td>
<td>
L
</td>
<td>Predicted oxygenase catalyzing oxidative demethylation of damaged DNA, 2OG-oxygenase superfamily</td>
</tr>
<tr>
<td>761</td>
<td>786</td>
<td><a href="/research/cog/cog/COG3857/">COG3857</a></td>
<td>
L
</td>
<td>ATP-dependent helicase/DNAse subunit B</td>
</tr>
<tr>
<td>329</td>
<td>363</td>
<td><a href="/research/cog/cog/COG3886/">COG3886</a></td>
<td>
L
</td>
<td>HKD family nuclease</td>
</tr>
<tr>
<td>568</td>
<td>572</td>
<td><a href="/research/cog/cog/COG3893/">COG3893</a></td>
<td>
L
</td>
<td>Inactivated superfamily I helicase</td>
</tr>
<tr>
<td>105</td>
<td>105</td>
<td><a href="/research/cog/cog/COG3923/">COG3923</a></td>
<td>
L
</td>
<td>Primosomal replication protein N&#x27;&#x27;</td>
</tr>
<tr>
<td>348</td>
<td>469</td>
<td><a href="/research/cog/cog/COG3935/">COG3935</a></td>
<td>
L
</td>
<td>DNA replication protein DnaD</td>
</tr>
<tr>
<td>161</td>
<td>175</td>
<td><a href="/research/cog/cog/COG3972/">COG3972</a></td>
<td>
L
</td>
<td>Superfamily I DNA and RNA helicases</td>
</tr>
<tr>
<td>471</td>
<td>794</td>
<td><a href="/research/cog/cog/COG3973/">COG3973</a></td>
<td>
L
</td>
<td>DNA helicase IV</td>
</tr>
<tr>
<td>41</td>
<td>42</td>
<td><a href="/research/cog/cog/COG4047/">COG4047</a></td>
<td>
L
</td>
<td>N-glycosylase/DNA lyase (8-oxoguanine DNA glycosylase)</td>
</tr>
<tr>
<td>188</td>
<td>194</td>
<td><a href="/research/cog/cog/COG4098/">COG4098</a></td>
<td>
L
</td>
<td>Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein)</td>
</tr>
<tr>
<td>151</td>
<td>151</td>
<td><a href="/research/cog/cog/COG4199/">COG4199</a></td>
<td>
L
</td>
<td>ssDNA-specific exonuclease RecJ</td>
</tr>
<tr>
<td>356</td>
<td>573</td>
<td><a href="/research/cog/cog/COG4227/">COG4227</a></td>
<td>
L
</td>
<td>Antirestriction protein ArdC</td>
</tr>
<tr>
<td>206</td>
<td>235</td>
<td><a href="/research/cog/cog/COG4294/">COG4294</a></td>
<td>
L
</td>
<td>UV DNA damage repair endonuclease</td>
</tr>
<tr>
<td>304</td>
<td>324</td>
<td><a href="/research/cog/cog/COG4335/">COG4335</a></td>
<td>
L
</td>
<td>3-methylpurine DNA glycosylase AlkC</td>
</tr>
<tr>
<td>163</td>
<td>169</td>
<td><a href="/research/cog/cog/COG4389/">COG4389</a></td>
<td>
L
</td>
<td>Site-specific recombinase</td>
</tr>
<tr>
<td>50</td>
<td>59</td>
<td><a href="/research/cog/cog/COG4396/">COG4396</a></td>
<td>
L
X
</td>
<td>Mu-like prophage host-nuclease inhibitor protein Gam can participate in DNA repair</td>
</tr>
<tr>
<td>184</td>
<td>186</td>
<td><a href="/research/cog/cog/COG4467/">COG4467</a></td>
<td>
L
</td>
<td>Regulator of replication initiation timing YabA</td>
</tr>
<tr>
<td>425</td>
<td>491</td>
<td><a href="/research/cog/cog/COG4544/">COG4544</a></td>
<td>
L
</td>
<td>Translesion DNA synthesis-associated protein ImuA</td>
</tr>
<tr>
<td>237</td>
<td>293</td>
<td><a href="/research/cog/cog/COG4570/">COG4570</a></td>
<td>
L
</td>
<td>Holliday junction resolvase RusA (prophage-encoded endonuclease)</td>
</tr>
<tr>
<td>689</td>
<td>929</td>
<td><a href="/research/cog/cog/COG4581/">COG4581</a></td>
<td>
L
</td>
<td>Superfamily II RNA helicase</td>
</tr>
<tr>
<td>173</td>
<td>236</td>
<td><a href="/research/cog/cog/COG4646/">COG4646</a></td>
<td>
L
</td>
<td>Adenine-specific DNA methylase, N12 class</td>
</tr>
<tr>
<td>41</td>
<td>51</td>
<td><a href="/research/cog/cog/COG4688/">COG4688</a></td>
<td>
L
</td>
<td>Predicted site-specific recombinase/integrase</td>
</tr>
<tr>
<td>54</td>
<td>72</td>
<td><a href="/research/cog/cog/COG4712/">COG4712</a></td>
<td>
L
</td>
<td>Predicted ssDNA annealing protein, contains HHH motif, Rad42/Rad22/RecT/erf family</td>
</tr>
<tr>
<td>497</td>
<td>556</td>
<td><a href="/research/cog/cog/COG4717/">COG4717</a></td>
<td>
L
</td>
<td>Predicted ATPase SbcE/YhaN involved in DNA double-strand break repair, contains AAA domain</td>
</tr>
<tr>
<td>93</td>
<td>131</td>
<td><a href="/research/cog/cog/COG4817/">COG4817</a></td>
<td>
L
</td>
<td>DNA-binding ferritin-like protein (Dps family)</td>
</tr>
<tr>
<td>674</td>
<td>821</td>
<td><a href="/research/cog/cog/COG4912/">COG4912</a></td>
<td>
L
</td>
<td>3-methyladenine DNA glycosylase AlkD</td>
</tr>
<tr>
<td>796</td>
<td>1068</td>
<td><a href="/research/cog/cog/COG4973/">COG4973</a></td>
<td>
L
</td>
<td>Site-specific recombinase XerC</td>
</tr>
<tr>
<td>2201</td>
<td>13250</td>
<td><a href="/research/cog/cog/COG4974/">COG4974</a></td>
<td>
L
</td>
<td>Site-specific tyrosine recombinase XerD</td>
</tr>
<tr>
<td>22</td>
<td>22</td>
<td><a href="/research/cog/cog/COG4998/">COG4998</a></td>
<td>
L
</td>
<td>Predicted endonuclease, RecB family</td>
</tr>
<tr>
<td>7</td>
<td>7</td>
<td><a href="/research/cog/cog/COG5055/">COG5055</a></td>
<td>
L
</td>
<td>Recombinational DNA repair protein (RAD52 pathway)</td>
</tr>
<tr>
<td>4</td>
<td>4</td>
<td><a href="/research/cog/cog/COG5235/">COG5235</a></td>
<td>
L
</td>
<td>Single-stranded DNA-binding replication protein A (RPA), 30 kD subunit</td>
</tr>
<tr>
<td>228</td>
<td>1073</td>
<td><a href="/research/cog/cog/COG5464/">COG5464</a></td>
<td>
L
</td>
<td>Recombination-promoting DNA endonuclease RpnC/YadD</td>
</tr>
<tr>
<td>66</td>
<td>133</td>
<td><a href="/research/cog/cog/COG5851/">COG5851</a></td>
<td>
L
D
</td>
<td>Stage 0 sporulation inhibitor Sda, checkpoint for initiation of sporulation and replication</td>
</tr>
<tr>
<td>12</td>
<td>12</td>
<td><a href="/research/cog/cog/COG6115/">COG6115</a></td>
<td>
L
</td>
<td>Replication initiator protein WhiP, Cdt1-like family</td>
</tr>
<tr>
<td>7</td>
<td>7</td>
<td><a href="/research/cog/cog/COG6116/">COG6116</a></td>
<td>
L
</td>
<td>Eukaryotic-type DNA primase, noncatalytic subunit PriX</td>
</tr>
<tr>
<td>20</td>
<td>26</td>
<td><a href="/research/cog/cog/COG6117/">COG6117</a></td>
<td>
L
</td>
<td>Eukaryotic-type DNA primase, small subunit homolog</td>
</tr>
<tr>
<td>21</td>
<td>21</td>
<td><a href="/research/cog/cog/COG6118/">COG6118</a></td>
<td>
L
</td>
<td>Eukaryotic-type DNA primase, LigD-like domain</td>
</tr>
<tr>
<td>5</td>
<td>5</td>
<td><a href="/research/cog/cog/COG6119/">COG6119</a></td>
<td>
L
</td>
<td>DNA replication initiation complex subunit, GINS23-like (arCOG05026) family</td>
</tr>
<tr>
<td>4</td>
<td>4</td>
<td><a href="/research/cog/cog/COG6123/">COG6123</a></td>
<td>
L
</td>
<td>Protein TIP, PCNA inhibitor</td>
</tr>
<tr>
<td>21</td>
<td>21</td>
<td><a href="/research/cog/cog/COG6124/">COG6124</a></td>
<td>
L
</td>
<td>DNA polymerase PolB1 small subunit PBP1</td>
</tr>
<tr>
<td>23</td>
<td>23</td>
<td><a href="/research/cog/cog/COG6125/">COG6125</a></td>
<td>
L
</td>
<td>DNA polymerase PolB1 small subunit PBP2, contains HTH domain</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
</section>
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