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<div class="facet_cont" data-db="pmc" data-default_grps="fg_types,fg_text_availability,fg_pubdate,fg_funding" data-sd="db:'pmc',op:'search',term:'first-line',qk:'2242',linkname:'',idsfromresult:'',extra:''"><ul class="facet" data-filter_id="types" id="_types"><li class="filter_grp "><div class="clearfix"><h3>Article attributes</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="associateddata">Associated Data</a></li><li class="fil_val"><a href="#" data-value_id="manuscripts">Author manuscripts</a></li><li class="fil_val"><a href="#" data-value_id="digitazed">Digitized back issues</a></li><li class="fil_val"><a href="#" data-value_id="medline">MEDLINE journals</a></li><li class="fil_val"><a href="#" data-value_id="openaccess">Open access</a></li><li class="fil_val"><a href="#" data-value_id="preprint">Preprints</a></li><li class="fil_val"><a href="#" data-value_id="retracted">Retracted</a></li></ul></li></ul><ul class="facet" data-filter_id="text_availability" id="_text_availability"><li class="filter_grp "><div class="clearfix"><h3>Text availability</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="embargoed">Include embargoed articles</a></li></ul></li></ul><ul class="facet" data-filter_id="pubdate" data-ds="yes" id="_pubdate"><li class="filter_grp"><div class="clearfix"><h3>Publication date</h3><a href="#" data-value_id="" class="clear clear_hide">clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="y_1">1 year</a></li><li class="fil_val"><a href="#" data-value_id="y_5">5 years</a></li><li class="fil_val"><a href="#" data-value_id="y_10">10 years</a></li><li class="daterange"><a id="facet_date_rangepubdate" href="#facet_date_range_divpubdate" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'">
Custom range...</a></li><div id="facet_date_range_divpubdate" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Custom date range</h4><div><label class="offscreen_noflow" for="facet_date_st_yearpubdate">Start Year</label><input type="text" size="4" placeholder="YYYY" id="facet_date_st_yearpubdate" value="" class="input_date_ym" /><label class="offscreen_noflow" for="facet_date_st_monthpubdate">Start Month</label><input type="text" size="2" placeholder="MM" id="facet_date_st_monthpubdate" value="" class="input_date_ym" /><label class="offscreen_noflow" for="facet_date_st_daypubdate">Start Day</label><input type="text" size="2" placeholder="DD" id="facet_date_st_daypubdate" value="" /><span>to</span><label class="offscreen_noflow" for="facet_date_end_yearpubdate">End Year</label><input type="text" size="4" placeholder="YYYY" id="facet_date_end_yearpubdate" value="" class="input_date_ym" /><label class="offscreen_noflow" for="facet_date_end_monthpubdate">End Month</label><input type="text" size="2" placeholder="MM" id="facet_date_end_monthpubdate" value="" class="input_date_ym" /><label class="offscreen_noflow" for="facet_date_end_daypubdate">End Day</label><input type="text" size="2" placeholder="DD" id="facet_date_end_daypubdate" value="" /></div><div class="actions clearfix"><button class="jig-ncbibutton primary-action btn_date_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'" id="facet_date_range_applypubdate">Apply</button><button class="jig-ncbibutton secondary-action btn_date_clear" data-jigconfig="'color': 'ui-ncbibutton-gray'" id="facet_date_range_clearpubdate">Clear</button></div></div></ul></li></ul><ul class="facet" data-filter_id="funding" id="_funding"><li class="filter_grp "><div class="clearfix"><h3>Research Funder</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="funder_nih">NIH</a></li><li class="fil_val"><a href="#" data-value_id="funder_ahrq">AHRQ</a></li><li class="fil_val"><a href="#" data-value_id="funder_acl">ACL</a></li><li class="fil_val"><a href="#" data-value_id="funder_aspr">ASPR</a></li><li class="fil_val"><a href="#" data-value_id="funder_cdc">CDC</a></li><li class="fil_val"><a href="#" data-value_id="funder_dhs">DHS</a></li><li class="fil_val"><a href="#" data-value_id="funder_epa">EPA</a></li><li class="fil_val"><a href="#" data-value_id="funder_fda">FDA</a></li><li class="fil_val"><a href="#" data-value_id="funder_nasa">NASA</a></li><li class="fil_val"><a href="#" data-value_id="funder_nist">NIST</a></li><li class="fil_val"><a href="#" data-value_id="funder_va">VA</a></li><li class="more"><a href="#funding_more" data-value_id="fetch_more" data-jigconfig=" hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '300px'">Customize ...</a><div style="display:none;" id="funding_more"></div></li></ul></li></ul><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
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<div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox10339786" class="ui-helper-hidden-accessible">Select item 10339786</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="1" type="checkbox" id="UidCheckBox10339786" value="10339786" /><span>1.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=1&amp;ncbi_uid=10339786&amp;link_uid=10339786&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10339786/" class="view">Firstline diuretics versus other classes of antihypertensive drugs for hypertension</a></div><div class="supp"><div class="details">Cochrane Database Syst Rev. <span class="citation-publication-date">2023; </span>2023(7): CD008161. <span class="">Published online 2023 Jul 13. </span><span class="doi"><span>doi: </span>10.1002/14651858.CD008161.pub3</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC10339786</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=1&amp;ncbi_uid=10339786&amp;link_uid=10339786&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10339786/">Article</a><a ref="ordinalpos=1&amp;ncbi_uid=10339786&amp;link_uid=10339786&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10339786/pdf/CD008161.pdf">PDF1.2M</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox9999022" class="ui-helper-hidden-accessible">Select item 9999022</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="2" type="checkbox" id="UidCheckBox9999022" value="9999022" /><span>2.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=2&amp;ncbi_uid=9999022&amp;link_uid=9999022&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC9999022/" class="view">Effectiveness and cost-effectiveness analysis of 11 treatment paths, seven <b>first-line</b> and three second-line treatments for Chinese patients with advanced wild-type squamous non-small cell lung cancer: A sequential model</a></div><div class="supp"><div class="desc">Mingye Zhao, Taihang Shao, Zhuoyuan Chi, Wenxi Tang</div><div class="details">Front Public Health. <span class="citation-publication-date">2023; </span>11: 1051484. <span class="">Published online 2023 Feb 24. </span><span class="doi"><span>doi: </span>10.3389/fpubh.2023.1051484</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC9999022</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=2&amp;ncbi_uid=9999022&amp;link_uid=9999022&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC9999022/">Article</a><a ref="ordinalpos=2&amp;ncbi_uid=9999022&amp;link_uid=9999022&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC9999022/pdf/fpubh-11-1051484.pdf">PDF3.4M</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox10685024" class="ui-helper-hidden-accessible">Select item 10685024</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="3" type="checkbox" id="UidCheckBox10685024" value="10685024" /><span>3.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=3&amp;ncbi_uid=10685024&amp;link_uid=10685024&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10685024/" class="view">Avelumab <b>first-line</b> maintenance treatment for advanced urothelial carcinoma: review of evidence to guide clinical practice</a></div><div class="supp"><div class="desc">P. Grivas, E. Grande, I.D. Davis, H.H. Moon, M.-O. Grimm, S. Gupta, P. Barthélémy, C. Thibault, S. Guenther, S. Hanson, C.N. Sternberg</div><div class="details">ESMO Open. <span class="citation-publication-date">2023 Dec; </span>8(6): 102050. <span class="">Published online 2023 Oct 12. </span><span class="doi"><span>doi: </span>10.1016/j.esmoop.2023.102050</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC10685024</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=3&amp;ncbi_uid=10685024&amp;link_uid=10685024&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10685024/">Article</a><a ref="ordinalpos=3&amp;ncbi_uid=10685024&amp;link_uid=10685024&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10685024/pdf/main.pdf">PDF622K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox10798763" class="ui-helper-hidden-accessible">Select item 10798763</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="4" type="checkbox" id="UidCheckBox10798763" value="10798763" /><span>4.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=4&amp;ncbi_uid=10798763&amp;link_uid=10798763&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10798763/" class="view">Advances and challenges of <b>first-line</b> immunotherapy for non-small cell lung cancer: A review</a></div><div class="supp"><div class="desc">Haiyang Guo, Jun Zhang, Chao Qin, Hang Yan, Xinyue Luo, Haining Zhou</div><div class="details">Medicine (Baltimore) <span class="citation-publication-date">2024 Jan 19; </span>103(3): e36861. <span class="">Published online 2024 Jan 19. </span><span class="doi"><span>doi: </span>10.1097/MD.0000000000036861</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC10798763</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=4&amp;ncbi_uid=10798763&amp;link_uid=10798763&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10798763/">Article</a><a ref="ordinalpos=4&amp;ncbi_uid=10798763&amp;link_uid=10798763&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10798763/pdf/medi-103-e36861.pdf">PDF611K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox10594593" class="ui-helper-hidden-accessible">Select item 10594593</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="5" type="checkbox" id="UidCheckBox10594593" value="10594593" /><span>5.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=5&amp;ncbi_uid=10594593&amp;link_uid=10594593&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10594593/" class="view">Antiseizure medications for neonates with seizures</a></div><div class="supp"><div class="details">Cochrane Database Syst Rev. <span class="citation-publication-date">2023; </span>2023(10): CD014967. <span class="">Published online 2023 Oct 24. </span><span class="doi"><span>doi: </span>10.1002/14651858.CD014967.pub2</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC10594593</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=5&amp;ncbi_uid=10594593&amp;link_uid=10594593&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10594593/">Article</a><a ref="ordinalpos=5&amp;ncbi_uid=10594593&amp;link_uid=10594593&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10594593/pdf/CD014967.pdf">PDF1.5M</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox11651285" class="ui-helper-hidden-accessible">Select item 11651285</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="6" type="checkbox" id="UidCheckBox11651285" value="11651285" /><span>6.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=6&amp;ncbi_uid=11651285&amp;link_uid=11651285&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11651285/" class="view"><b>First-line</b> treatments for KRAS-mutant non-small cell lung cancer: current state and future perspectives</a></div><div class="supp"><div class="desc">Qi He, Xiaoyan Liu, Liyan Jiang, Ping Liu, Weixia Xuan, Yudong Wang, Rui Meng, Huijing Feng, Shuang Lv, Qian Miao, Di Zheng, Yan Xu, Mengzhao Wang</div><div class="details">Cancer Biol Ther. <span class="citation-publication-date">2025; </span>26(1): 2441499. <span class="">Published online 2024 Dec 16. </span><span class="doi"><span>doi: </span>10.1080/15384047.2024.2441499</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC11651285</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=6&amp;ncbi_uid=11651285&amp;link_uid=11651285&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11651285/">Article</a><a ref="ordinalpos=6&amp;ncbi_uid=11651285&amp;link_uid=11651285&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11651285/pdf/KCBT_26_2441499.pdf">PDF818K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox10785354" class="ui-helper-hidden-accessible">Select item 10785354</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="7" type="checkbox" id="UidCheckBox10785354" value="10785354" /><span>7.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=7&amp;ncbi_uid=10785354&amp;link_uid=10785354&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10785354/" class="view">A network meta-analysis of efficacy and safety for <b>first-line</b> and second/further-line therapies in postmenopausal women with hormone receptor-positive, HER2-negative, advanced breast cancer</a></div><div class="supp"><div class="desc">Hanqiao Shao, Mingye Zhao, Ai-Jia Guan, Taihang Shao, Dachuang Zhou, Guo Yu, Wenxi Tang</div><div class="details">BMC Med. <span class="citation-publication-date">2024; </span>22: 13. <span class="">Published online 2024 Jan 12. </span><span class="doi"><span>doi: </span>10.1186/s12916-023-03238-2</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC10785354</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=7&amp;ncbi_uid=10785354&amp;link_uid=10785354&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10785354/">Article</a><a ref="ordinalpos=7&amp;ncbi_uid=10785354&amp;link_uid=10785354&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10785354/pdf/12916_2023_Article_3238.pdf">PDF3.2M</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox8908405" class="ui-helper-hidden-accessible">Select item 8908405</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="8" type="checkbox" id="UidCheckBox8908405" value="8908405" /><span>8.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=8&amp;ncbi_uid=8908405&amp;link_uid=8908405&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8908405/" class="view">Vedolizumab has longer persistence than infliximab as a <b>first-line</b> biological agent but not as a second-line biological agent in moderate-to-severe ulcerative colitis: real-world registry data from the Persistence Australian National IBD Cohort (PANIC) study</a></div><div class="supp"><div class="desc">Aviv Pudipeddi, Yanna Ko, Sudarshan Paramsothy, Rupert W. Leong</div><div class="details">Therap Adv Gastroenterol. <span class="citation-publication-date">2022; </span>15: 17562848221080793. <span class="">Published online 2022 Mar 8. </span><span class="doi"><span>doi: </span>10.1177/17562848221080793</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC8908405</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=8&amp;ncbi_uid=8908405&amp;link_uid=8908405&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8908405/">Article</a><a ref="ordinalpos=8&amp;ncbi_uid=8908405&amp;link_uid=8908405&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8908405/pdf/10.1177_17562848221080793.pdf">PDF3.2M</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox8859866" class="ui-helper-hidden-accessible">Select item 8859866</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="9" type="checkbox" id="UidCheckBox8859866" value="8859866" /><span>9.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=9&amp;ncbi_uid=8859866&amp;link_uid=8859866&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8859866/" class="view">Weekly versus triweekly paclitaxel with carboplatin for firstline treatment in women with epithelial ovarian cancer</a></div><div class="supp"><div class="details">Cochrane Database Syst Rev. <span class="citation-publication-date">2022; </span>2022(2): CD012007. <span class="">Published online 2022 Feb 21. </span><span class="doi"><span>doi: </span>10.1002/14651858.CD012007.pub2</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC8859866</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=9&amp;ncbi_uid=8859866&amp;link_uid=8859866&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8859866/">Article</a><a ref="ordinalpos=9&amp;ncbi_uid=8859866&amp;link_uid=8859866&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8859866/pdf/CD012007.pdf">PDF1.3M</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox10665706" class="ui-helper-hidden-accessible">Select item 10665706</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="10" type="checkbox" id="UidCheckBox10665706" value="10665706" /><span>10.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=10&amp;ncbi_uid=10665706&amp;link_uid=10665706&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10665706/" class="view">Efficacy and safety of utidelone plus capecitabine in advanced <b>first-line</b> therapy for metastatic breast cancer: A multicenter real-world study</a></div><div class="supp"><div class="desc">Pingping Bi, Xi Wang, Rui Liu, Xiuqin Li, Shanrong Wei, Jiawen Zhao, Xin Tan, Fan Zhang, Qing Mao, Ying Zhang, Baoyan Tang, Xueqiong Xun, Rong Guo, Kai Zheng, Shaoqiang Zhou, Shicong Tang</div><div class="details">Surg Open Sci. <span class="citation-publication-date">2023 Dec; </span>16: 171183. <span class="">Published online 2023 Oct 31. </span><span class="doi"><span>doi: </span>10.1016/j.sopen.2023.10.008</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC10665706</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=10&amp;ncbi_uid=10665706&amp;link_uid=10665706&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10665706/">Article</a><a ref="ordinalpos=10&amp;ncbi_uid=10665706&amp;link_uid=10665706&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10665706/pdf/main.pdf">PDF7.4M</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox9412220" class="ui-helper-hidden-accessible">Select item 9412220</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="11" type="checkbox" id="UidCheckBox9412220" value="9412220" /><span>11.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=11&amp;ncbi_uid=9412220&amp;link_uid=9412220&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC9412220/" class="view">Use of <b>First-Line</b> Immune Checkpoint Inhibitors and Association With Overall Survival Among Patients With Metastatic Melanoma in the AntiPD-1 Era</a></div><div class="supp"><div class="desc">Nayan Lamba, Patrick A. Ott, J. Bryan Iorgulescu</div><div class="details">JAMA Netw Open. <span class="citation-publication-date">2022 Aug; </span>5(8): e2225459. <span class="">Published online 2022 Aug 25. </span><span class="doi"><span>doi: </span>10.1001/jamanetworkopen.2022.25459</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC9412220</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=11&amp;ncbi_uid=9412220&amp;link_uid=9412220&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC9412220/">Article</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox6516995" class="ui-helper-hidden-accessible">Select item 6516995</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="12" type="checkbox" id="UidCheckBox6516995" value="6516995" /><span>12.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=12&amp;ncbi_uid=6516995&amp;link_uid=6516995&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6516995/" class="view">Firstline drugs inhibiting the renin angiotensin system versus other firstline antihypertensive drug classes for hypertension</a></div><div class="supp"><div class="desc">Yu Jie Chen, Liang Jin Li, Wen Lu Tang, Jia Yang Song, Ru Qiu, Qian Li, Hao Xue, James M Wright, Cochrane Hypertension Group</div><div class="details">Cochrane Database Syst Rev. <span class="citation-publication-date">2018; </span>2018(11): CD008170. <span class="">Published online 2018 Nov 14. </span><span class="doi"><span>doi: </span>10.1002/14651858.CD008170.pub3</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC6516995</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=12&amp;ncbi_uid=6516995&amp;link_uid=6516995&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6516995/">Article</a><a ref="ordinalpos=12&amp;ncbi_uid=6516995&amp;link_uid=6516995&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6516995/pdf/CD008170.pdf">PDF1.0M</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox6513559" class="ui-helper-hidden-accessible">Select item 6513559</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="13" type="checkbox" id="UidCheckBox6513559" value="6513559" /><span>13.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=13&amp;ncbi_uid=6513559&amp;link_uid=6513559&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6513559/" class="view">Firstline drugs for hypertension</a></div><div class="supp"><div class="desc">James M Wright, Vijaya M Musini, Rupam Gill, Cochrane Hypertension Group</div><div class="details">Cochrane Database Syst Rev. <span class="citation-publication-date">2018; </span>2018(4): CD001841. <span class="">Published online 2018 Apr 18. </span><span class="doi"><span>doi: </span>10.1002/14651858.CD001841.pub3</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC6513559</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=13&amp;ncbi_uid=6513559&amp;link_uid=6513559&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6513559/">Article</a><a ref="ordinalpos=13&amp;ncbi_uid=6513559&amp;link_uid=6513559&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6513559/pdf/CD001841.pdf">PDF1.1M</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox8733836" class="ui-helper-hidden-accessible">Select item 8733836</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="14" type="checkbox" id="UidCheckBox8733836" value="8733836" /><span>14.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=14&amp;ncbi_uid=8733836&amp;link_uid=8733836&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8733836/" class="view">Outcomes Among African American and Non-Hispanic White Men With Metastatic Castration-Resistant Prostate Cancer With <b>First-Line</b> Abiraterone</a></div><div class="supp"><div class="desc">Mallika Marar, Qi Long, Ronac Mamtani, Vivek Narayan, Neha Vapiwala, Ravi B. Parikh</div><div class="details">JAMA Netw Open. <span class="citation-publication-date">2022 Jan; </span>5(1): e2142093. <span class="">Published online 2022 Jan 5. </span><span class="doi"><span>doi: </span>10.1001/jamanetworkopen.2021.42093</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC8733836</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=14&amp;ncbi_uid=8733836&amp;link_uid=8733836&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8733836/">Article</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox7932942" class="ui-helper-hidden-accessible">Select item 7932942</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="15" type="checkbox" id="UidCheckBox7932942" value="7932942" /><span>15.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=15&amp;ncbi_uid=7932942&amp;link_uid=7932942&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7932942/" class="view">Clinical Impact of Adherence to NCCN Guidelines for Biomarker Testing and <b>First-Line</b> Treatment in Advanced Non-Small Cell Lung Cancer (aNSCLC) Using Real-World Electronic Health Record Data</a></div><div class="supp"><div class="desc">Ani John, Baiyu Yang, Roma Shah</div><div class="details">Adv Ther. <span class="citation-publication-date">2021; </span>38(3): 15521566. <span class="">Published online 2021 Feb 4. </span><span class="doi"><span>doi: </span>10.1007/s12325-020-01617-2</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC7932942</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=15&amp;ncbi_uid=7932942&amp;link_uid=7932942&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7932942/">Article</a><a ref="ordinalpos=15&amp;ncbi_uid=7932942&amp;link_uid=7932942&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7932942/pdf/12325_2020_Article_1617.pdf">PDF1.0M</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox9046540" class="ui-helper-hidden-accessible">Select item 9046540</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="16" type="checkbox" id="UidCheckBox9046540" value="9046540" /><span>16.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=16&amp;ncbi_uid=9046540&amp;link_uid=9046540&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC9046540/" class="view">Influential Factors, Treatment and Prognosis of Autoimmune Encephalitis Patients With Poor Response to Short-Term <b>First-Line</b> Treatment</a></div><div class="supp"><div class="desc">Fei Liu, Bingbing Zhang, Teng Huang, Baojie Wang, Chunjuan Wang, Maolin Hao, Shougang Guo</div><div class="details">Front Neurol. <span class="citation-publication-date">2022; </span>13: 861988. <span class="">Published online 2022 Apr 14. </span><span class="doi"><span>doi: </span>10.3389/fneur.2022.861988</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC9046540</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=16&amp;ncbi_uid=9046540&amp;link_uid=9046540&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC9046540/">Article</a><a ref="ordinalpos=16&amp;ncbi_uid=9046540&amp;link_uid=9046540&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC9046540/pdf/fneur-13-861988.pdf">PDF896K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox11671897" class="ui-helper-hidden-accessible">Select item 11671897</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="17" type="checkbox" id="UidCheckBox11671897" value="11671897" /><span>17.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=17&amp;ncbi_uid=11671897&amp;link_uid=11671897&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11671897/" class="view">Physician-reported patient involvement and treatment decisions in <b>first-line</b> ovarian cancer in the USA and Europe</a></div><div class="supp"><div class="desc">Kathleen N Moore, Mansoor R Mirza, Charlie Gourley, Sandro Pignata, Domenica Lorusso, Bradley J Monk, Jalid Sehouli, Jeanne M Schilder, Nathalie D'Esquermes, Antonio González-Martín</div><div class="details">Int J Gynecol Cancer. <span class="citation-publication-date">2024 Aug; </span>34(11): e005405. <span class="">Published online 2024 Aug 20. </span><span class="doi"><span>doi: </span>10.1136/ijgc-2024-005405</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC11671897</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=17&amp;ncbi_uid=11671897&amp;link_uid=11671897&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11671897/">Article</a><a ref="ordinalpos=17&amp;ncbi_uid=11671897&amp;link_uid=11671897&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11671897/pdf/ijgc-34-11.pdf">PDF602K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox11735459" class="ui-helper-hidden-accessible">Select item 11735459</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="18" type="checkbox" id="UidCheckBox11735459" value="11735459" /><span>18.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=18&amp;ncbi_uid=11735459&amp;link_uid=11735459&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11735459/" class="view">RealWorld Study of <span style="fixed-case">EGFR</span><span style="fixed-case">TKI</span> Rechallenge With Another <span style="fixed-case">TKI</span> After FirstLine Osimertinib Discontinuation in Patients With <span style="fixed-case">EGFR</span>Mutated NonSmall Cell Lung Cancer: A Subset Analysis of the Reiwa Study</a></div><div class="supp"><div class="desc">Kei Sonehara, Kazunari Tateishi, Kiyotaka Yoh, Kazuhiro Usui, Yukio Hosomi, Kazuma Kishi, Go Naka, Kageaki Watanabe, Shu Tamano, Kohei Uemura, Hideo Kunitoh</div><div class="details">Thorac Cancer. <span class="citation-publication-date">2025 Jan; </span>16(2): e15507. <span class="">Published online 2024 Dec 7. </span><span class="doi"><span>doi: </span>10.1111/1759-7714.15507</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC11735459</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=18&amp;ncbi_uid=11735459&amp;link_uid=11735459&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11735459/">Article</a><a ref="ordinalpos=18&amp;ncbi_uid=11735459&amp;link_uid=11735459&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11735459/pdf/TCA-16-e15507.pdf">PDF325K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox11534108" class="ui-helper-hidden-accessible">Select item 11534108</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="19" type="checkbox" id="UidCheckBox11534108" value="11534108" /><span>19.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=19&amp;ncbi_uid=11534108&amp;link_uid=11534108&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11534108/" class="view">Real-world <b>first-line</b> treatment patterns and outcomes in recurrent/advanced endometrial cancer patients in Europe</a></div><div class="supp"><div class="desc">Jingchuan Zhang, Sneha S Kelkar, Vimalanand S Prabhu, Yoscar M Ogando, Rishi P Verma, Véronique Grall, Christian Marth</div><div class="details">Future Oncol. <span class="citation-publication-date">2024; </span>20(34): 26372645. <span class="">Published online 2024 Aug 9. </span><span class="doi"><span>doi: </span>10.1080/14796694.2024.2379233</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC11534108</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=19&amp;ncbi_uid=11534108&amp;link_uid=11534108&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11534108/">Article</a><a ref="ordinalpos=19&amp;ncbi_uid=11534108&amp;link_uid=11534108&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11534108/pdf/IFON_20_2379233.pdf">PDF1.2M</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox11781729" class="ui-helper-hidden-accessible">Select item 11781729</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="20" type="checkbox" id="UidCheckBox11781729" value="11781729" /><span>20.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=20&amp;ncbi_uid=11781729&amp;link_uid=11781729&amp;linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11781729/" class="view"><b>First-line</b> glaucoma monotherapy medication patterns in Finland during 19952019 based on a population-based study</a></div><div class="supp"><div class="desc">Petri K. M. Purola, Seppo V. P. Koskinen, Hannu M. T. Uusitalo</div><div class="details">PLoS One. <span class="citation-publication-date">2025; </span>20(1): e0316835. <span class="">Published online 2025 Jan 30. </span><span class="doi"><span>doi: </span>10.1371/journal.pone.0316835</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC11781729</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=20&amp;ncbi_uid=11781729&amp;link_uid=11781729&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11781729/">Article</a><a ref="ordinalpos=20&amp;ncbi_uid=11781729&amp;link_uid=11781729&amp;linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11781729/pdf/pone.0316835.pdf">PDF1.9M</a></div></div></div></div></div>
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<a co-legend-rid="indivImg1" image-link="/pmc/articles/PMC6787520/figure/F3/" class="img_link figpopup imagepopup" href="/pmc/articles/PMC6787520" ref="log$=PMC_ImageAd&amp;discoId=PMC_ImageAd&amp;ncbi_uid=15533197&amp;link_uid=PMC6787520&amp;pos=1">
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<div class="legend-from"><span class="legend-from-title">Figure 3. </span>Overall survival analysis in participants treated with first-line chemoimmunotherapy versus chemotherapy alone.</div>
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<div><b>(A)</b> Pooled HR for OS in patients with advanced NSCLC treated with first-line chemoimmunotherapy. <b>(B)</b> Pooled HR for OS in patients with advanced squamous NSCLC treated with first-line chemoimmunotherapy. <b>(C)</b> Pooled HR for OS in patients with advanced nonsquamous NSCLC treated with first-line chemoimmunotherapy. <b>(D)</b> Pooled HR for OS in patients with advanced NSCLC treated with PD-1 inhibitor (pembrolizumab) in combination with chemotherapy in the first-line setting. <b>(E)</b> Pooled HR for OS in patients with advanced NSCLC treated with PD-L1 inhibitor (atezolizumab) in combination with chemotherapy in the first-line setting. <b>(F)</b> Pooled HR for OS in PD-L1 negative patients with advanced NSCLC in the first-line setting. <b>(G)</b> Pooled HR for OS in PD-L1 low patients with advanced NSCLC in the first-line setting. <b>(H)</b> Pooled HR for OS in PD-L1 high patients with advanced NSCLC in the first-line setting.<br />HR: Hazard ratio; NSCLC: Non-small-cell lung cancer; OS: Overall survival; PD-1: Programmed death receptor 1; PD-L1: Programmed death ligand 1.</div>
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<a href="/pmc/articles/PMC6787520" ref="log$=PMC_ImageAd_title_link&amp;discoId=PMC_ImageAd&amp;ncbi_uid=15533197&amp;link_uid=PMC6787520&amp;pos=1">Checkpoint inhibitors plus chemotherapy for first-line treatment of advanced non-small cell lung cancer: a systematic review and meta-analysis of randomized controlled trials</a>
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<div>Future Sci OA. 2019 Oct;5(9):FSO421.</div>
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<div>One-stage IPD-pooled analysis of first-line studies (CheckMate-649, KEYNOTE-859, and ORIENT-16). (<b>a</b>) Overall survival in first-line studies with a CPS of &lt;1. (<b>b</b>) Overall survival in first-line studies with a CPS of ≥1. (<b>c</b>) Overall survival in first-line studies with a CPS of &lt;5. (<b>d</b>) Overall survival in first-line studies with a CPS of ≥5. (<b>e</b>) Progression-free survival in first-line studies with a CPS of &lt;1. (<b>f</b>) Progression-free survival in first-line studies with a CPS of ≥1. (<b>g</b>) Progression-free survival in first-line studies with a CPS of &lt;5. (<b>h</b>) Progression-free survival in first-line studies with a CPS of ≥5.</div>
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<a href="/pmc/articles/PMC11852535" ref="log$=PMC_ImageAd_title_link&amp;discoId=PMC_ImageAd&amp;ncbi_uid=36859465&amp;link_uid=PMC11852535&amp;pos=2">Deeper Analysis to Identify the True Benefit of ICIs Immunotherapy in First-Line Treatment for Non-HER2-Positive/HER2-Negative Advanced or Metastatic Advanced or Metastatic Gastric Cancer (GC) or Gastroesophageal Junction Cancer (GEJC)</a>
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<div>Cancers (Basel). 2025 Feb;17(4):657.</div>
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<span class="legend-from-title">Figure 3</span>
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<div>Tornado diagram showing the results of the deterministic sensitivity analysis. NN, first-line nedaplatin-based chemotherapy followed by second-line nivolumab; NT, first-line nedaplatin-based chemotherapy followed by second-line tislelizumab; ND, first-line nedaplatin-based chemotherapy followed by second-line docetaxel; CN, first-line standard chemotherapy followed by second-line nivolumab; CT, first-line standard chemotherapy followed by second-line tislelizumab; CD, first-line standard chemotherapy followed by second-line docetaxel; TID, first-line tislelizumab combined with chemotherapy followed by second-line docetaxel; CAD, first-line camrelizumab combined with chemotherapy followed by second-line docetaxel; PED, first-line pembrolizumab combined with chemotherapy followed by second-line docetaxel; SID, first-line sintilimab combined with chemotherapy followed by second-line docetaxel; SUD, first-line sugemalimab combined with chemotherapy followed by second-line docetaxel; HR, hazards rations; OS, overall survival; PFS, progression-free survival; PD, progression disease; Cam, camrelizumab; Tis, tislelizumab; Niv, nivolumab; Che, Chemotheraphy; Dox, docetaxel; BSC, best support care; IM, immunotheraphy; Sug, sugemalimab; Sin, sintilimab; Pem, pembrolizumab; CT, computed tomography; AE, adverse events.</div>
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<a href="/pmc/articles/PMC9999022" ref="log$=PMC_ImageAd_title_link&amp;discoId=PMC_ImageAd&amp;ncbi_uid=27378841&amp;link_uid=PMC9999022&amp;pos=3">Effectiveness and cost-effectiveness analysis of 11 treatment paths, seven first-line and three second-line treatments for Chinese patients with advanced wild-type squamous non-small cell lung cancer: A sequential model</a>
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<div>Front Public Health. 2023;11:1051484.</div>
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<div class="legend-from"><span class="legend-from-title">Figure 4. </span>Progression-free survival analysis in participants treated with first-line chemoimmunotherapy versus standard chemotherapy regimen.</div>
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<div><b>(A)</b> Pooled HR for PFS in patients with advanced NSCLC treated with first-line chemoimmunotherapy. <b>(B)</b> Pooled HR for PFS in patients with advanced squamous NSCLC treated with first-line chemoimmunotherapy. <b>(C)</b> Pooled HR for PFS in patients with advanced nonsquamous NSCLC treated with first-line chemoimmunotherapy. <b>(D)</b> Pooled HR for PFS in patients with advanced NSCLC treated with PD-1 inhibitor (nivolumab or pembrolizumab) in combination with chemotherapy in the first-line setting. <b>(E)</b> Pooled HR for PFS in patients with advanced NSCLC treated with PD-L1 inhibitor (atezolizumab) in combination with chemotherapy in the first-line setting. <b>(F)</b> Pooled HR for PFS in PD-L1 negative patients with advanced NSCLC in the first-line setting. <b>(G)</b> Pooled HR for PFS in PD-L1 low patients with advanced NSCLC in the first-line setting. <b>(H)</b> Pooled HR for PFS in PD-L1 high patients with advanced NSCLC in the first-line setting. <b>(I)</b> Pooled HR for PFS in patients with <i>EGFR</i> and <i>ALK</i> mutated advanced NSCLC treated with atezolizumab.<br />HR: Hazard ratio; NSCLC: Non-small-cell lung cancer; OS: Overall survival; PD-1: Programmed death receptor 1; PD-L1: Programmed death ligand 1; PFS: Progression-free survival.</div>
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<p class="address_footer text-white">National Library of Medicine<br />
<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
Bethesda, MD 20894</a></p>
</div>
<div class="col-lg-3 col-12 centered-lg">
<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
</div>
<div class="col-lg-3 col-12 centered-lg">
<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
</div>
</div>
<div class="row">
<div class="col-lg-12 centered-lg">
<nav class="bottom-links">
<ul class="mt-3">
<li>
<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
</li>
<li>
<a class="text-white" href="https://www.nih.gov/">NIH</a>
</li>
<li>
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
</li>
<li>
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
</li>
</ul>
</nav>
</div>
</div>
</div>
</section>
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