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<meta name="keywords" content="C5436916, carpal tunnel syndrome 2, comp, cts2, disease or syndrome, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Carpal tunnel syndrome-2 (CTS2) is characterized by the relatively early onset of symptoms of median nerve compression in the wrist. Patients experience pain and numbness in the thumb, index, and middle fingers, correlating with the median nerve distribution in the hand. In addition to thickening of the tendons and ligaments of the wrist, thickening of other tendons has been observed (Li et al., 2020).&#13; For a general phenotypic description and discussion of genetic heterogeneity of carpal tunnel syndrome, see CTS1 (115430)." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Carpal tunnel syndrome 2 (Concept Id: C5436916)
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<!--
UID=1725962
ConceptID=C5436916
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Carpal tunnel syndrome 2<span class="h1sub">(CTS2)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1725962</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C5436916</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>CARPAL TUNNEL SYNDROME 2; CTS2</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
Gene(s) directly associated with<br />
this condition or phenotype.</div></td>
<td><a target="_blank" title="COMP - ID: 1311 - NCBI Gene" href="/gene/1311" class="medgenPMinfo">COMP</a> (19p13.11)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0030883" target="_blank">MONDO:0030883</a></td></tr>
<tr><td>OMIM<span class="superscript">®</span>:</td>
<td><a href="https://omim.org/entry/619161" target="_blank">619161</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Carpal tunnel syndrome-2 (CTS2) is characterized by the relatively early onset of symptoms of median nerve compression in the wrist. Patients experience pain and numbness in the thumb, index, and middle fingers, correlating with the median nerve distribution in the hand. In addition to thickening of the tendons and ligaments of the wrist, thickening of other tendons has been observed (Li et al., 2020).&#13; For a general phenotypic description and discussion of genetic heterogeneity of carpal tunnel syndrome, see CTS1 (115430). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
</div>
<div class="portlet mgSection" id="ID_102">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
<div class="divPopper rprt" id="clin_536933"><div><strong>Hand pain</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>536933</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0239833</a></dd><dt><span class="dotprefix"></span></dt><dd>Sign or Symptom</dd></dl></div></div></div>
<div class="spaceAbove">An unpleasant sensation characterized by physical discomfort localized to the hand.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/536933">Feature record</a> | <a href="/medgen?term=%22Hand%20pain%22%5BClinical%20Features%5D%20OR%20536933%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_536934"><div><strong>Hand paresthesia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>536934</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0239836</a></dd><dt><span class="dotprefix"></span></dt><dd>Sign or Symptom</dd></dl></div></div></div>
<div class="spaceAbove">Tingling (often referred to as a pins and needles feeling) and numbness in the hand.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/536934">Feature record</a> | <a href="/medgen?term=%22Hand%20paresthesia%22%5BClinical%20Features%5D%20OR%20536934%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_660310"><div><strong>Positive Phalen test</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>660310</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0576714</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">The Phalen maneuver is performed by having the patient hold both wrists in complete and forced flexion (pushing the dorsal surfaces of both hands together) for 30-60 seconds. This can increase the pressure in the carpal tunnel. The test is positive (abnormal) if the patient experiences characteristic symptoms of carpal tunnel syndrome (pain and paresthesias along the distribution of the median nerve, i.e., thumb, index finger, and middle finger).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/660310">Feature record</a> | <a href="/medgen?term=%22Positive%20Phalen%20test%22%5BClinical%20Features%5D%20OR%20660310%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_868610"><div><strong>Constrictive median neuropathy</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>868610</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4023009</a></dd><dt><span class="dotprefix"></span></dt><dd>Anatomical Abnormality</dd></dl></div></div></div>
<div class="spaceAbove">Injury to the median nerve caused by its entrapment at the wrist as it traverses through the carpal tunnel. Clinically, constrictive median neuropathy is characterized by pain, paresthesia, and weakness in the median nerve distribution of the hand.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/868610">Feature record</a> | <a href="/medgen?term=%22Constrictive%20median%20neuropathy%22%5BClinical%20Features%5D%20OR%20868610%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_1779488"><div><strong>Positive carpal Tinel sign</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1779488</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5539755</a></dd><dt><span class="dotprefix"></span></dt><dd>Laboratory or Test Result</dd></dl></div></div></div>
<div class="spaceAbove">The Tinel test is performed by lightly tapping (percussing) over the median nerve. It is positive (abnormal) if the patient experiences pain and paresthesias (tingling, numbness) along the distribution of the median nerve.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen?term=%22Positive%20carpal%20Tinel%20sign%22%5BClinical%20Features%5D%20OR%201779488%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_355274"><div><strong>Thenar muscle atrophy</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>355274</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1864715</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">Wasting of thenar muscles, which are located on palm of the hand at the base of the thumb.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/355274">Feature record</a> | <a href="/medgen?term=%22Thenar%20muscle%20atrophy%22%5BClinical%20Features%5D%20OR%20355274%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(&quot;.TreeLite&quot;,&quot;#ID_102&quot;).TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(&quot;.TreeLite&quot;,&quot;#ID_102&quot;).TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of the musculoskeletal system</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_355274" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Thenar muscle atrophy</a></span></li></ul></li><li><span class="TLline">Abnormality of the nervous system</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_868610" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Constrictive median neuropathy</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_536934" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hand paresthesia</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1779488" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Positive carpal Tinel sign</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_660310" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Positive Phalen test</a></span></li></ul></li><li><span class="TLline">Constitutional symptom</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_536933" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hand pain</a></span></li></ul></li></ul></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/28654613">Evidence-Based Medicine: Current Evidence in the Diagnosis and Management of Carpal Tunnel Syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hermiz SJ,
Kalliainen LK</span><br />
<span class="medgenPMjournal">Plast Reconstr Surg</span>
2017 Jul;140(1):120e-129e.
doi: 10.1097/PRS.0000000000003477.
<span class="bold">PMID: </span><a href="/pubmed/28654613" target="_blank">28654613</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22carpal%20tunnel%20syndrome%202%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/32893098">The long-term effect of neurodynamics vs exercise therapy on pain and function in people with carpal tunnel syndrome: A randomized parallel-group clinical trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hamzeh H,
Madi M,
Alghwiri AA,
Hawamdeh Z</span><br />
<span class="medgenPMjournal">J Hand Ther</span>
2021 Oct-Dec;34(4):521-530.
Epub 2020 Jul 30
doi: 10.1016/j.jht.2020.07.005.
<span class="bold">PMID: </span><a href="/pubmed/32893098" target="_blank">32893098</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32063607">Effectiveness of home exercise in pregnant women with carpal tunnel syndrome: Randomized Control Trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Keskin Y,
Kilic G,
Taspinar O,
Posul SO,
Halac G,
Eren F,
Erol E,
Urkmez B,
Aydin T</span><br />
<span class="medgenPMjournal">J Pak Med Assoc</span>
2020 Feb;70(2):202-207.
doi: 10.5455/JPMA.1846.
<span class="bold">PMID: </span><a href="/pubmed/32063607" target="_blank">32063607</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29499823">Carpal Tunnel Syndrome: Making Evidence-Based Treatment Decisions.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Calandruccio JH,
Thompson NB</span><br />
<span class="medgenPMjournal">Orthop Clin North Am</span>
2018 Apr;49(2):223-229.
Epub 2018 Feb 1
doi: 10.1016/j.ocl.2017.11.009.
<span class="bold">PMID: </span><a href="/pubmed/29499823" target="_blank">29499823</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24448791">Editorial: carpal tunnel syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Giddins G</span><br />
<span class="medgenPMjournal">J Hand Surg Eur Vol</span>
2014 Feb;39(2):131.
doi: 10.1177/1753193413518139.
<span class="bold">PMID: </span><a href="/pubmed/24448791" target="_blank">24448791</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18269111">Carpal tunnel syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Aroori S,
Spence RA</span><br />
<span class="medgenPMjournal">Ulster Med J</span>
2008 Jan;77(1):6-17.
<span class="bold">PMID: </span><a href="/pubmed/18269111" target="_blank">18269111</a><a href="/pmc/articles/PMC2397020" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carpal%20tunnel%20syndrome%202%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2224)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/33548133">Non-classical presentation of carpal tunnel syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cooke R</span><br />
<span class="medgenPMjournal">Occup Med (Lond)</span>
2021 Feb 6;71(1):2-3.
doi: 10.1093/occmed/kqaa118.
<span class="bold">PMID: </span><a href="/pubmed/33548133" target="_blank">33548133</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32893098">The long-term effect of neurodynamics vs exercise therapy on pain and function in people with carpal tunnel syndrome: A randomized parallel-group clinical trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hamzeh H,
Madi M,
Alghwiri AA,
Hawamdeh Z</span><br />
<span class="medgenPMjournal">J Hand Ther</span>
2021 Oct-Dec;34(4):521-530.
Epub 2020 Jul 30
doi: 10.1016/j.jht.2020.07.005.
<span class="bold">PMID: </span><a href="/pubmed/32893098" target="_blank">32893098</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20504142">Carpal tunnel syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jakubowicz B,
Aner M</span><br />
<span class="medgenPMjournal">J Pain Palliat Care Pharmacother</span>
2010 Jun;24(2):162-3.
doi: 10.3109/15360281003799221.
<span class="bold">PMID: </span><a href="/pubmed/20504142" target="_blank">20504142</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18269111">Carpal tunnel syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Aroori S,
Spence RA</span><br />
<span class="medgenPMjournal">Ulster Med J</span>
2008 Jan;77(1):6-17.
<span class="bold">PMID: </span><a href="/pubmed/18269111" target="_blank">18269111</a><a href="/pmc/articles/PMC2397020" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10411196">Prevalence of carpal tunnel syndrome in a general population.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Atroshi I,
Gummesson C,
Johnsson R,
Ornstein E,
Ranstam J,
Rosén I</span><br />
<span class="medgenPMjournal">JAMA</span>
1999 Jul 14;282(2):153-8.
doi: 10.1001/jama.282.2.153.
<span class="bold">PMID: </span><a href="/pubmed/10411196" target="_blank">10411196</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carpal%20tunnel%20syndrome%202%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1915)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/35762992">Common Hand Conditions: A Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Currie KB,
Tadisina KK,
Mackinnon SE</span><br />
<span class="medgenPMjournal">JAMA</span>
2022 Jun 28;327(24):2434-2445.
doi: 10.1001/jama.2022.8481.
<span class="bold">PMID: </span><a href="/pubmed/35762992" target="_blank">35762992</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28942118">Carpal Tunnel Syndrome: Effectiveness of Physical Therapy and Electrophysical Modalities. An Updated Systematic Review of Randomized Controlled Trials.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Huisstede BM,
Hoogvliet P,
Franke TP,
Randsdorp MS,
Koes BW</span><br />
<span class="medgenPMjournal">Arch Phys Med Rehabil</span>
2018 Aug;99(8):1623-1634.e23.
Epub 2017 Sep 20
doi: 10.1016/j.apmr.2017.08.482.
<span class="bold">PMID: </span><a href="/pubmed/28942118" target="_blank">28942118</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26884379">Rehabilitation following carpal tunnel release.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Peters S,
Page MJ,
Coppieters MW,
Ross M,
Johnston V</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2016 Feb 17;2(2):CD004158.
doi: 10.1002/14651858.CD004158.pub3.
<span class="bold">PMID: </span><a href="/pubmed/26884379" target="_blank">26884379</a><a href="/pmc/articles/PMC10493644" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22696387">Exercise and mobilisation interventions for carpal tunnel syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Page MJ,
O'Connor D,
Pitt V,
Massy-Westropp N</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2012 Jun 13;2012(6):CD009899.
doi: 10.1002/14651858.CD009899.
<span class="bold">PMID: </span><a href="/pubmed/22696387" target="_blank">22696387</a><a href="/pmc/articles/PMC11536321" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/11500151">Dialysis-related amyloidosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fukuda K,
Yamamoto H</span><br />
<span class="medgenPMjournal">Semin Musculoskelet Radiol</span>
2001 Jun;5(2):113-9.
doi: 10.1055/s-2001-15879.
<span class="bold">PMID: </span><a href="/pubmed/11500151" target="_blank">11500151</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carpal%20tunnel%20syndrome%202%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1280)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/29499823">Carpal Tunnel Syndrome: Making Evidence-Based Treatment Decisions.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Calandruccio JH,
Thompson NB</span><br />
<span class="medgenPMjournal">Orthop Clin North Am</span>
2018 Apr;49(2):223-229.
Epub 2018 Feb 1
doi: 10.1016/j.ocl.2017.11.009.
<span class="bold">PMID: </span><a href="/pubmed/29499823" target="_blank">29499823</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28334999">Rewiring the primary somatosensory cortex in carpal tunnel syndrome with acupuncture.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Maeda Y,
Kim H,
Kettner N,
Kim J,
Cina S,
Malatesta C,
Gerber J,
McManus C,
Ong-Sutherland R,
Mezzacappa P,
Libby A,
Mawla I,
Morse LR,
Kaptchuk TJ,
Audette J,
Napadow V</span><br />
<span class="medgenPMjournal">Brain</span>
2017 Apr 1;140(4):914-927.
doi: 10.1093/brain/awx015.
<span class="bold">PMID: </span><a href="/pubmed/28334999" target="_blank">28334999</a><a href="/pmc/articles/PMC5837382" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26281946">Manual Physical Therapy Versus Surgery for Carpal Tunnel Syndrome: A Randomized Parallel-Group Trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fernández-de-Las Peñas C,
Ortega-Santiago R,
de la Llave-Rincón AI,
Martínez-Perez A,
Fahandezh-Saddi Díaz H,
Martínez-Martín J,
Pareja JA,
Cuadrado-Pérez ML</span><br />
<span class="medgenPMjournal">J Pain</span>
2015 Nov;16(11):1087-94.
Epub 2015 Aug 15
doi: 10.1016/j.jpain.2015.07.012.
<span class="bold">PMID: </span><a href="/pubmed/26281946" target="_blank">26281946</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22361370">The electrodiagnostic approach to carpal tunnel syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Watson JC</span><br />
<span class="medgenPMjournal">Neurol Clin</span>
2012 May;30(2):457-78.
Epub 2012 Jan 17
doi: 10.1016/j.ncl.2011.12.001.
<span class="bold">PMID: </span><a href="/pubmed/22361370" target="_blank">22361370</a></div>
<div class="nl"><a target="_blank" href="/pubmed/11500151">Dialysis-related amyloidosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fukuda K,
Yamamoto H</span><br />
<span class="medgenPMjournal">Semin Musculoskelet Radiol</span>
2001 Jun;5(2):113-9.
doi: 10.1055/s-2001-15879.
<span class="bold">PMID: </span><a href="/pubmed/11500151" target="_blank">11500151</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carpal%20tunnel%20syndrome%202%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (929)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/36637026">Efficacy of median nerve hydrodissection by hyalase versus midazolam in the treatment of carpal tunnel syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Raouf MM,
Abo-Elhessein AK,
Hasanein M,
Abskharon JE,
Hassan SS,
Talaat EA,
Elawamy AR,
Kamel EZ</span><br />
<span class="medgenPMjournal">Pain Manag</span>
2023 Feb;13(2):77-86.
Epub 2023 Jan 13
doi: 10.2217/pmt-2022-0080.
<span class="bold">PMID: </span><a href="/pubmed/36637026" target="_blank">36637026</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33855879">Effectiveness of Tendon and Nerve Gliding Exercises in the Treatment of Patients With Mild Idiopathic Carpal Tunnel Syndrome: A Randomized Controlled Trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Abdolrazaghi HA,
Khansari M,
Mirshahi M,
Ahmadi Pishkuhi M</span><br />
<span class="medgenPMjournal">Hand (N Y)</span>
2023 Mar;18(2):222-229.
Epub 2021 Apr 15
doi: 10.1177/15589447211006857.
<span class="bold">PMID: </span><a href="/pubmed/33855879" target="_blank">33855879</a><a href="/pmc/articles/PMC10035085" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33351153">Effectiveness of focused extracorporeal shock wave therapy in the treatment of carpal tunnel syndrome : A randomized, placebo-controlled pilot study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gesslbauer C,
Mickel M,
Schuhfried O,
Huber D,
Keilani M,
Crevenna R</span><br />
<span class="medgenPMjournal">Wien Klin Wochenschr</span>
2021 Jun;133(11-12):568-577.
Epub 2020 Dec 22
doi: 10.1007/s00508-020-01785-9.
<span class="bold">PMID: </span><a href="/pubmed/33351153" target="_blank">33351153</a><a href="/pmc/articles/PMC7754699" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32893098">The long-term effect of neurodynamics vs exercise therapy on pain and function in people with carpal tunnel syndrome: A randomized parallel-group clinical trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hamzeh H,
Madi M,
Alghwiri AA,
Hawamdeh Z</span><br />
<span class="medgenPMjournal">J Hand Ther</span>
2021 Oct-Dec;34(4):521-530.
Epub 2020 Jul 30
doi: 10.1016/j.jht.2020.07.005.
<span class="bold">PMID: </span><a href="/pubmed/32893098" target="_blank">32893098</a></div>
<div class="nl"><a target="_blank" href="/pubmed/8245050">A self-administered questionnaire for the assessment of severity of symptoms and functional status in carpal tunnel syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Levine DW,
Simmons BP,
Koris MJ,
Daltroy LH,
Hohl GG,
Fossel AH,
Katz JN</span><br />
<span class="medgenPMjournal">J Bone Joint Surg Am</span>
1993 Nov;75(11):1585-92.
doi: 10.2106/00004623-199311000-00002.
<span class="bold">PMID: </span><a href="/pubmed/8245050" target="_blank">8245050</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carpal%20tunnel%20syndrome%202%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1350)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/36848651">Splinting for carpal tunnel syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Karjalainen TV,
Lusa V,
Page MJ,
O'Connor D,
Massy-Westropp N,
Peters SE</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2023 Feb 27;2(2):CD010003.
doi: 10.1002/14651858.CD010003.pub2.
<span class="bold">PMID: </span><a href="/pubmed/36848651" target="_blank">36848651</a><a href="/pmc/articles/PMC9969978" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36346880">Ultrasound-guided injection of platelet-rich plasma for tendinopathies: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Masiello F,
Pati I,
Veropalumbo E,
Pupella S,
Cruciani M,
De Angelis V</span><br />
<span class="medgenPMjournal">Blood Transfus</span>
2023 Mar;21(2):119-136.
Epub 2022 Oct 17
doi: 10.2450/2022.0087-22.
<span class="bold">PMID: </span><a href="/pubmed/36346880" target="_blank">36346880</a><a href="/pmc/articles/PMC10072988" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34862562">The effectiveness of manual therapy on pain, physical function, and nerve conduction studies in carpal tunnel syndrome patients: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jiménez-Del-Barrio S,
Cadellans-Arróniz A,
Ceballos-Laita L,
Estébanez-de-Miguel E,
López-de-Celis C,
Bueno-Gracia E,
Pérez-Bellmunt A</span><br />
<span class="medgenPMjournal">Int Orthop</span>
2022 Feb;46(2):301-312.
Epub 2021 Dec 3
doi: 10.1007/s00264-021-05272-2.
<span class="bold">PMID: </span><a href="/pubmed/34862562" target="_blank">34862562</a><a href="/pmc/articles/PMC8782801" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28704626">The Effectiveness of Neural Mobilization for Neuromusculoskeletal Conditions: A Systematic Review and Meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Basson A,
Olivier B,
Ellis R,
Coppieters M,
Stewart A,
Mudzi W</span><br />
<span class="medgenPMjournal">J Orthop Sports Phys Ther</span>
2017 Sep;47(9):593-615.
Epub 2017 Jul 13
doi: 10.2519/jospt.2017.7117.
<span class="bold">PMID: </span><a href="/pubmed/28704626" target="_blank">28704626</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27842937">Effectiveness of Nerve Gliding Exercises on Carpal Tunnel Syndrome: A Systematic Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ballestero-Pérez R,
Plaza-Manzano G,
Urraca-Gesto A,
Romo-Romo F,
Atín-Arratibel MLÁ,
Pecos-Martín D,
Gallego-Izquierdo T,
Romero-Franco N</span><br />
<span class="medgenPMjournal">J Manipulative Physiol Ther</span>
2017 Jan;40(1):50-59.
Epub 2016 Nov 11
doi: 10.1016/j.jmpt.2016.10.004.
<span class="bold">PMID: </span><a href="/pubmed/27842937" target="_blank">27842937</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carpal%20tunnel%20syndrome%202%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (160)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C5436916%5bDISCUI%5d&amp;filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (2)</a></li>
<li><a href="/gtr/tests?term=C5436916%5bDISCUI%5d&amp;filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (2)</a></li>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22carpal%20tunnel%20syndrome%202%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Carpal%20tunnel%20syndrome%202%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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