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<meta name="keywords" content="C4749917, apc, familial fundic gland polyposis with gastric cancer, fundic gland polyposis, gapps, gapps - gastric adenocarcinoma and proximal polyposis of stomach, gastric adenocarcinoma and proximal polyposis of stomach, gastric adenocarcinoma and proximal polyposis of the stomach, neoplastic process, polyposis, gastric, polyposis, gastric, dos santos and de magalhaes 1980, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="APC-associated polyposis conditions include (classic or attenuated) familial adenomatous polyposis (FAP) and gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). FAP is a colorectal cancer (CRC) predisposition syndrome that can manifest in either classic or attenuated form. Classic FAP is characterized by hundreds to thousands of adenomatous colonic polyps, beginning on average at age 16 years (range 7-36 years). For those with the classic form of FAP, 95% of individuals have polyps by age 35 years; CRC is inevitable without colectomy. The mean age of CRC diagnosis in untreated individuals is 39 years (range 34-43 years). The attenuated form is characterized by multiple colonic polyps (average of 30), more proximally located polyps, and a diagnosis of CRC at a later age than in classic FAP. For those with an attenuated form, there is a 70% lifetime risk of CRC and the mean age of diagnosis is 50-55 years. Extracolonic manifestations are variably present and include polyps of the stomach and duodenum, osteomas, dental abnormalities, congenital hypertrophy of the retinal pigment epithelium (CHRPE), benign cutaneous lesions, desmoid tumors, adrenal masses, and other associated cancers. GAPPS is characterized by proximal gastric polyposis, increased risk of gastric adenocarcinoma, and no duodenal or colonic involvement in most individuals reported." /><meta name="robots" content="index,nofollow,noarchive" />
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<div><div class="rprt full-rprt"><div class="portlet" style="border-top-style: none; margin-top: 0px; padding-top: 0px; margin-bottom: 0px; padding-left: 0.2em;">
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<!--
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||
UID=1657285
|
||
ConceptID=C4749917
|
||
-->
|
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<!--imgCountBooks = 1--><div class="ncbi_carousel" data-ncbicarousel-config="imageWidth:'100px',numItemsVisible:2,toggler:false"><div class="nc_header"><span class="img_strip_title">Image</span></div><div class="nc_content"><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1345/bin/fap-Image001.gif" src-large="/books/NBK1345/bin/fap-Image001.jpg" /></a><br /><a href="/books/NBK1345/figure/fap.F1/" title="GeneReviews" target="_blank">details</a></div></div></div><h1 class="medgenTitle"><div class="MedGenTitleText">Gastric adenocarcinoma and proximal polyposis of the stomach<span class="h1sub">(GAPPS)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1657285</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C4749917</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>GAPPS; POLYPOSIS, GASTRIC; Polyposis, gastric, Dos Santos and de Magalhaes 1980</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>GAPPS - gastric adenocarcinoma and proximal polyposis of stomach (771474005); Gastric adenocarcinoma and proximal polyposis of stomach (771474005); Familial fundic gland polyposis with gastric cancer (771474005)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_141047"><div><strong>Autosomal dominant inheritance</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>141047</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0443147</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Intellectual Product</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.</div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_141047" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant inheritance</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="APC - ID: 324 - NCBI Gene" href="/gene/324" class="medgenPMinfo">APC</a> (5q22.2)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0017790" target="_blank">MONDO:0017790</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/619182" target="_blank">619182</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=314022">ORPHA314022</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_101">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Disease_characteristics">Disease characteristics</h1><a sid="101" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="excerpt">Excerpted from the <i>GeneReview: </i><a href="/books/NBK1345" target="_blank">APC-Associated Polyposis Conditions</a></div><div>APC-associated polyposis conditions include (classic or attenuated) familial adenomatous polyposis (FAP) and gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). FAP is a colorectal cancer (CRC) predisposition syndrome that can manifest in either classic or attenuated form. Classic FAP is characterized by hundreds to thousands of adenomatous colonic polyps, beginning on average at age 16 years (range 7-36 years). For those with the classic form of FAP, 95% of individuals have polyps by age 35 years; CRC is inevitable without colectomy. The mean age of CRC diagnosis in untreated individuals is 39 years (range 34-43 years). The attenuated form is characterized by multiple colonic polyps (average of 30), more proximally located polyps, and a diagnosis of CRC at a later age than in classic FAP. For those with an attenuated form, there is a 70% lifetime risk of CRC and the mean age of diagnosis is 50-55 years. Extracolonic manifestations are variably present and include polyps of the stomach and duodenum, osteomas, dental abnormalities, congenital hypertrophy of the retinal pigment epithelium (CHRPE), benign cutaneous lesions, desmoid tumors, adrenal masses, and other associated cancers. GAPPS is characterized by proximal gastric polyposis, increased risk of gastric adenocarcinoma, and no duodenal or colonic involvement in most individuals reported. [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div><div class="spaceAbove"><strong>Full text of <i>GeneReview</i> (by section):</strong><br /><a class="medgenPMinfo" href="/books/NBK1345#fap.Summary" target="NBK1345">Summary</a> | <a class="medgenPMinfo" href="/books/NBK1345#fap.GeneReview_Scope" target="NBK1345">GeneReview Scope</a> | <a class="medgenPMinfo" href="/books/NBK1345#fap.Diagnosis" target="NBK1345">Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1345#fap.Clinical_Characteristics" target="NBK1345">Clinical Characteristics</a> | <a class="medgenPMinfo" href="/books/NBK1345#fap.Genetically_Related_Allelic_Disorder" target="NBK1345">Genetically Related (Allelic) Disorders</a> | <a class="medgenPMinfo" href="/books/NBK1345#fap.Differential_Diagnosis" target="NBK1345">Differential Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1345#fap.Management" target="NBK1345">Management</a> | <a class="medgenPMinfo" href="/books/NBK1345#fap.Genetic_Counseling" target="NBK1345">Genetic Counseling</a> | <a class="medgenPMinfo" href="/books/NBK1345#fap.Resources" target="NBK1345">Resources</a> | <a class="medgenPMinfo" href="/books/NBK1345#fap.Molecular_Genetics" target="NBK1345">Molecular Genetics</a> | <a class="medgenPMinfo" href="/books/NBK1345#fap.Chapter_Notes" target="NBK1345">Chapter Notes</a> | <a class="medgenPMinfo" href="/books/NBK1345#fap.References" target="NBK1345">References</a></div><div class="spaceAbove"><strong>Authors:</strong><br />
|
||
Timothy Yen | Peter P Stanich | Lisen Axell<i>, et. al.</i> <a href="/books/NBK1345" target="NBK1345" title="NCBI Bookshelf: APC-Associated Polyposis Conditions">view full author information</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_117">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_description">Additional description</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From OMIM</strong><br />Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is characterized by autosomal dominant transmission of fundic gland polyposis (FGP) with occasional hyperplastic and adenomatous polyps, sparing of the gastric antrum, and the development of intestinal-type gastric adenocarcinoma. Colorectal polyposis is not observed, and family history does not include colorectal cancer (Worthley et al., 2012). <a target="_blank" href="http://www.omim.org/entry/619182">http://www.omim.org/entry/619182</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_7803"><div><strong>Abdominal pain</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>7803</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0000737</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Sign or Symptom</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/7803">Feature record</a> | <a href="/medgen?term=%22Abdominal%20pain%22%5BClinical%20Features%5D%20OR%207803%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_7523"><div><strong>Melena</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>7523</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0025222</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The passage of blackish, tarry feces associated with gastrointestinal hemorrhage. Melena occurs if the blood remains in the colon long enough for it to be broken down by colonic bacteria. One degradation product, hematin, imbues the stool with a blackish color. Thus, melena generally occurs with bleeding from the upper gastrointestinal tract (e.g., stomach ulcers or duodenal ulcers), since the blood usually remains in the gut for a longer period of time than with lower gastrointestinal bleeding.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/7523">Feature record</a> | <a href="/medgen?term=%22Melena%22%5BClinical%20Features%5D%20OR%207523%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_82961"><div><strong>Gastric adenocarcinoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82961</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0278701</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An adenocarcinoma arising from the stomach glandular epithelium. Gastric carcinoma often produces no specific symptoms when it is superficial and potentially surgically curable, although up to 50% of patients may have nonspecific gastrointestinal complaints such as dyspepsia.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/82961">Feature record</a> | <a href="/medgen?term=%22Gastric%20adenocarcinoma%22%5BClinical%20Features%5D%20OR%2082961%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_357403"><div><strong>Polyposis of gastric fundus without polyposis coli</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>357403</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1868001</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Multiple polyps in the acid-secreting mucosa of the gastric body and fundus. Fundic gland polyps (FGP) are usually 1 to 5 mm in size, though larger polyps have been found. FGPs are typically sessile, shiny, translucent, pale to pinkish in color (resembling the surrounding mucosa), and often exhibit tiny surface blood vessels. These polyps have characteristically been observed to chunk off or detach entirely at the base when removed with cold forceps, in contrast to other types of gastric polyps.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/357403">Feature record</a> | <a href="/medgen?term=%22Polyposis%20of%20gastric%20fundus%20without%20polyposis%20coli%22%5BClinical%20Features%5D%20OR%20357403%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of the digestive system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_82961" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Gastric adenocarcinoma</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_7523" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Melena</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_357403" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Polyposis of gastric fundus without polyposis coli</a></span></li></ul></li><li><span class="TLline">Constitutional symptom</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_7803" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Abdominal pain</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C4749917[DISCUI]&test_type=Clinical" ref="ncbi_uid=1657285">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1345/" ref="ncbi_uid=1657285">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=1657285" ref="ncbi_uid=1657285">V</a></span></span><span class="TLline">Gastric adenocarcinoma and proximal polyposis of the stomach</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/5527" ref="tree=MeSH" title="MedGen record for Hereditary disease">Hereditary disease</a></span><ul><li><span class="TLline"><a href="/medgen/14326" ref="tree=MeSH" title="MedGen record for Hereditary cancer-predisposing syndrome">Hereditary cancer-predisposing syndrome</a></span><ul><li><span class="matched_ds">Gastric adenocarcinoma and proximal polyposis of the stomach</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38722804">Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zaffaroni G,
|
||
Mannucci A,
|
||
Koskenvuo L,
|
||
de Lacy B,
|
||
Maffioli A,
|
||
Bisseling T,
|
||
Half E,
|
||
Cavestro GM,
|
||
Valle L,
|
||
Ryan N,
|
||
Aretz S,
|
||
Brown K,
|
||
Buttitta F,
|
||
Carneiro F,
|
||
Claber O,
|
||
Blanco-Colino R,
|
||
Collard M,
|
||
Crosbie E,
|
||
Cunha M,
|
||
Doulias T,
|
||
Fleming C,
|
||
Heinrich H,
|
||
Hüneburg R,
|
||
Metras J,
|
||
Nagtegaal I,
|
||
Negoi I,
|
||
Nielsen M,
|
||
Pellino G,
|
||
Ricciardiello L,
|
||
Sagir A,
|
||
Sánchez-Guillén L,
|
||
Seppälä TT,
|
||
Siersema P,
|
||
Striebeck B,
|
||
Sampson JR,
|
||
Latchford A,
|
||
Parc Y,
|
||
Burn J,
|
||
Möslein G</span><br />
|
||
<span class="medgenPMjournal">Br J Surg</span>
|
||
2024 May 3;111(5)
|
||
doi: 10.1093/bjs/znae070.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38722804" target="_blank">38722804</a><a href="/pmc/articles/PMC11081080" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29397239">Hereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Spoto CPE,
|
||
Gullo I,
|
||
Carneiro F,
|
||
Montgomery EA,
|
||
Brosens LAA</span><br />
|
||
<span class="medgenPMjournal">Semin Diagn Pathol</span>
|
||
2018 May;35(3):170-183.
|
||
Epub 2018 Jan 31
|
||
doi: 10.1053/j.semdp.2018.01.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29397239" target="_blank">29397239</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25638682">Familial gastric cancer: genetic susceptibility, pathology, and implications for management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Oliveira C,
|
||
Pinheiro H,
|
||
Figueiredo J,
|
||
Seruca R,
|
||
Carneiro F</span><br />
|
||
<span class="medgenPMjournal">Lancet Oncol</span>
|
||
2015 Feb;16(2):e60-70.
|
||
doi: 10.1016/S1470-2045(14)71016-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25638682" target="_blank">25638682</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22gastric%20adenocarcinoma%20and%20proximal%20polyposis%20of%20the%20stomach%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (3)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.acmg.net/ACMG/UploadedPDFS/PDFDocuments/Familial-Adenomatous-Polyposis-ACT-Sheet.aspx" target="_blank">American College of Medical Genetics and Genomics, Genomic Testing (Secondary Findings) ACT Sheet, APC Pathogenic Variants (Familial Adenomatous Polyposis [FAP]), 2019</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38722804">Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zaffaroni G,
|
||
Mannucci A,
|
||
Koskenvuo L,
|
||
de Lacy B,
|
||
Maffioli A,
|
||
Bisseling T,
|
||
Half E,
|
||
Cavestro GM,
|
||
Valle L,
|
||
Ryan N,
|
||
Aretz S,
|
||
Brown K,
|
||
Buttitta F,
|
||
Carneiro F,
|
||
Claber O,
|
||
Blanco-Colino R,
|
||
Collard M,
|
||
Crosbie E,
|
||
Cunha M,
|
||
Doulias T,
|
||
Fleming C,
|
||
Heinrich H,
|
||
Hüneburg R,
|
||
Metras J,
|
||
Nagtegaal I,
|
||
Negoi I,
|
||
Nielsen M,
|
||
Pellino G,
|
||
Ricciardiello L,
|
||
Sagir A,
|
||
Sánchez-Guillén L,
|
||
Seppälä TT,
|
||
Siersema P,
|
||
Striebeck B,
|
||
Sampson JR,
|
||
Latchford A,
|
||
Parc Y,
|
||
Burn J,
|
||
Möslein G</span><br />
|
||
<span class="medgenPMjournal">Br J Surg</span>
|
||
2024 May 3;111(5)
|
||
doi: 10.1093/bjs/znae070.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38722804" target="_blank">38722804</a><a href="/pmc/articles/PMC11081080" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34628409">Pathological Diversity of Gastric Cancer from the Viewpoint of Background Condition.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Abe H,
|
||
Ushiku T</span><br />
|
||
<span class="medgenPMjournal">Digestion</span>
|
||
2022;103(1):45-53.
|
||
Epub 2021 Oct 8
|
||
doi: 10.1159/000519337.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34628409" target="_blank">34628409</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33975682">Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) - A Helicobacter-opposite point.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tacheci I,
|
||
Repak R,
|
||
Podhola M,
|
||
Benesova L,
|
||
Cyrany J,
|
||
Bures J,
|
||
Kohoutova D</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Gastroenterol</span>
|
||
2021 Mar-Apr;50-51:101728.
|
||
Epub 2021 Feb 15
|
||
doi: 10.1016/j.bpg.2021.101728.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33975682" target="_blank">33975682</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31070935">Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dinarvand P,
|
||
Davaro EP,
|
||
Doan JV,
|
||
Ising ME,
|
||
Evans NR,
|
||
Phillips NJ,
|
||
Lai J,
|
||
Guzman MA</span><br />
|
||
<span class="medgenPMjournal">Arch Pathol Lab Med</span>
|
||
2019 Nov;143(11):1382-1398.
|
||
Epub 2019 May 9
|
||
doi: 10.5858/arpa.2018-0570-RA.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31070935" target="_blank">31070935</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23052347">Hereditary gastric cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Carneiro F</span><br />
|
||
<span class="medgenPMjournal">Pathologe</span>
|
||
2012 Nov;33 Suppl 2:231-4.
|
||
doi: 10.1007/s00292-012-1677-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23052347" target="_blank">23052347</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gastric%20adenocarcinoma%20and%20proximal%20polyposis%20of%20the%20stomach%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (22)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38722804">Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zaffaroni G,
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Mannucci A,
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Koskenvuo L,
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de Lacy B,
|
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Maffioli A,
|
||
Bisseling T,
|
||
Half E,
|
||
Cavestro GM,
|
||
Valle L,
|
||
Ryan N,
|
||
Aretz S,
|
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Brown K,
|
||
Buttitta F,
|
||
Carneiro F,
|
||
Claber O,
|
||
Blanco-Colino R,
|
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Collard M,
|
||
Crosbie E,
|
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Cunha M,
|
||
Doulias T,
|
||
Fleming C,
|
||
Heinrich H,
|
||
Hüneburg R,
|
||
Metras J,
|
||
Nagtegaal I,
|
||
Negoi I,
|
||
Nielsen M,
|
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Pellino G,
|
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Ricciardiello L,
|
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Sagir A,
|
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Sánchez-Guillén L,
|
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Seppälä TT,
|
||
Siersema P,
|
||
Striebeck B,
|
||
Sampson JR,
|
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Latchford A,
|
||
Parc Y,
|
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Burn J,
|
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Möslein G</span><br />
|
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<span class="medgenPMjournal">Br J Surg</span>
|
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2024 May 3;111(5)
|
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doi: 10.1093/bjs/znae070.
|
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<span class="bold">PMID: </span><a href="/pubmed/38722804" target="_blank">38722804</a><a href="/pmc/articles/PMC11081080" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35988963">Familial and hereditary gastric cancer, an overview.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Carneiro F</span><br />
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<span class="medgenPMjournal">Best Pract Res Clin Gastroenterol</span>
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2022 Jun-Aug;58-59:101800.
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Epub 2022 May 4
|
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doi: 10.1016/j.bpg.2022.101800.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35988963" target="_blank">35988963</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32712389">Gastric Adenocarcinoma and Proximal Polyposis of the Stomach Occurring With Ball Valve Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ako S,
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Kawano S,
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Okada H</span><br />
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<span class="medgenPMjournal">Clin Gastroenterol Hepatol</span>
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2022 Feb;20(2):e12-e13.
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Epub 2020 Jul 23
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doi: 10.1016/j.cgh.2020.07.044.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32712389" target="_blank">32712389</a></div>
|
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||
<div class="nl"><a target="_blank" href="/pubmed/33975682">Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) - A Helicobacter-opposite point.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Tacheci I,
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Repak R,
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Podhola M,
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Benesova L,
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Cyrany J,
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Bures J,
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Kohoutova D</span><br />
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<span class="medgenPMjournal">Best Pract Res Clin Gastroenterol</span>
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2021 Mar-Apr;50-51:101728.
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Epub 2021 Feb 15
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doi: 10.1016/j.bpg.2021.101728.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33975682" target="_blank">33975682</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31070935">Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dinarvand P,
|
||
Davaro EP,
|
||
Doan JV,
|
||
Ising ME,
|
||
Evans NR,
|
||
Phillips NJ,
|
||
Lai J,
|
||
Guzman MA</span><br />
|
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<span class="medgenPMjournal">Arch Pathol Lab Med</span>
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2019 Nov;143(11):1382-1398.
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Epub 2019 May 9
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doi: 10.5858/arpa.2018-0570-RA.
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||
<span class="bold">PMID: </span><a href="/pubmed/31070935" target="_blank">31070935</a></div>
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||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gastric%20adenocarcinoma%20and%20proximal%20polyposis%20of%20the%20stomach%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (23)</a></div><h3 class="subhead">Therapy</h3>
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||
<div class="nl"><a target="_blank" href="/pubmed/27406052">β-Catenin activation in fundic gland polyps, gastric cancer and colonic polyps in families afflicted by 'gastric adenocarcinoma and proximal polyposis of the stomach' (GAPPS).</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">McDuffie LA,
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Sabesan A,
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Allgäeuer M,
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Xin L,
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Koh C,
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Heller T,
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Davis JL,
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Raffeld M,
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Miettienen M,
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Quezado M,
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Rudloff U</span><br />
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<span class="medgenPMjournal">J Clin Pathol</span>
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2016 Sep;69(9):826-33.
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Epub 2016 Jul 12
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doi: 10.1136/jclinpath-2016-203746.
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<span class="bold">PMID: </span><a href="/pubmed/27406052" target="_blank">27406052</a><a href="/pmc/articles/PMC7831157" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gastric%20adenocarcinoma%20and%20proximal%20polyposis%20of%20the%20stomach%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31070935">Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dinarvand P,
|
||
Davaro EP,
|
||
Doan JV,
|
||
Ising ME,
|
||
Evans NR,
|
||
Phillips NJ,
|
||
Lai J,
|
||
Guzman MA</span><br />
|
||
<span class="medgenPMjournal">Arch Pathol Lab Med</span>
|
||
2019 Nov;143(11):1382-1398.
|
||
Epub 2019 May 9
|
||
doi: 10.5858/arpa.2018-0570-RA.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31070935" target="_blank">31070935</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29397239">Hereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Spoto CPE,
|
||
Gullo I,
|
||
Carneiro F,
|
||
Montgomery EA,
|
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Brosens LAA</span><br />
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<span class="medgenPMjournal">Semin Diagn Pathol</span>
|
||
2018 May;35(3):170-183.
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||
Epub 2018 Jan 31
|
||
doi: 10.1053/j.semdp.2018.01.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29397239" target="_blank">29397239</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25576241">Exome sequencing reveals three novel candidate predisposition genes for diffuse gastric cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Donner I,
|
||
Kiviluoto T,
|
||
Ristimäki A,
|
||
Aaltonen LA,
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Vahteristo P</span><br />
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<span class="medgenPMjournal">Fam Cancer</span>
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2015 Jun;14(2):241-6.
|
||
doi: 10.1007/s10689-015-9778-z.
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<span class="bold">PMID: </span><a href="/pubmed/25576241" target="_blank">25576241</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gastric%20adenocarcinoma%20and%20proximal%20polyposis%20of%20the%20stomach%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35988963">Familial and hereditary gastric cancer, an overview.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Carneiro F</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Gastroenterol</span>
|
||
2022 Jun-Aug;58-59:101800.
|
||
Epub 2022 May 4
|
||
doi: 10.1016/j.bpg.2022.101800.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35988963" target="_blank">35988963</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34554346">Prophylactic laparoscopic total gastrectomy for gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): the first report in Asia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Matsumoto C,
|
||
Iwatsuki M,
|
||
Iwagami S,
|
||
Morinaga T,
|
||
Yamashita K,
|
||
Nakamura K,
|
||
Eto K,
|
||
Kurashige J,
|
||
Baba Y,
|
||
Miyamoto Y,
|
||
Yoshida N,
|
||
Komohara Y,
|
||
Baba H</span><br />
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<span class="medgenPMjournal">Gastric Cancer</span>
|
||
2022 Mar;25(2):473-478.
|
||
Epub 2021 Sep 23
|
||
doi: 10.1007/s10120-021-01253-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34554346" target="_blank">34554346</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32533343">The clinicopathological and molecular features of sporadic gastric foveolar type neoplasia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sugai T,
|
||
Uesugi N,
|
||
Habano W,
|
||
Sugimoto R,
|
||
Eizuka M,
|
||
Fujita Y,
|
||
Osakabe M,
|
||
Toya Y,
|
||
Suzuki H,
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Matsumoto T</span><br />
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<span class="medgenPMjournal">Virchows Arch</span>
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||
2020 Dec;477(6):835-844.
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||
Epub 2020 Jun 12
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||
doi: 10.1007/s00428-020-02846-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32533343" target="_blank">32533343</a><a href="/pmc/articles/PMC7683467" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29397239">Hereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Spoto CPE,
|
||
Gullo I,
|
||
Carneiro F,
|
||
Montgomery EA,
|
||
Brosens LAA</span><br />
|
||
<span class="medgenPMjournal">Semin Diagn Pathol</span>
|
||
2018 May;35(3):170-183.
|
||
Epub 2018 Jan 31
|
||
doi: 10.1053/j.semdp.2018.01.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29397239" target="_blank">29397239</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29141268">Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) - a rare recently described gastric polyposis syndrome - report of a case.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Beer A,
|
||
Streubel B,
|
||
Asari R,
|
||
Dejaco C,
|
||
Oberhuber G</span><br />
|
||
<span class="medgenPMjournal">Z Gastroenterol</span>
|
||
2017 Nov;55(11):1131-1134.
|
||
Epub 2017 Nov 15
|
||
doi: 10.1055/s-0043-117182.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29141268" target="_blank">29141268</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gastric%20adenocarcinoma%20and%20proximal%20polyposis%20of%20the%20stomach%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/38722804">Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zaffaroni G,
|
||
Mannucci A,
|
||
Koskenvuo L,
|
||
de Lacy B,
|
||
Maffioli A,
|
||
Bisseling T,
|
||
Half E,
|
||
Cavestro GM,
|
||
Valle L,
|
||
Ryan N,
|
||
Aretz S,
|
||
Brown K,
|
||
Buttitta F,
|
||
Carneiro F,
|
||
Claber O,
|
||
Blanco-Colino R,
|
||
Collard M,
|
||
Crosbie E,
|
||
Cunha M,
|
||
Doulias T,
|
||
Fleming C,
|
||
Heinrich H,
|
||
Hüneburg R,
|
||
Metras J,
|
||
Nagtegaal I,
|
||
Negoi I,
|
||
Nielsen M,
|
||
Pellino G,
|
||
Ricciardiello L,
|
||
Sagir A,
|
||
Sánchez-Guillén L,
|
||
Seppälä TT,
|
||
Siersema P,
|
||
Striebeck B,
|
||
Sampson JR,
|
||
Latchford A,
|
||
Parc Y,
|
||
Burn J,
|
||
Möslein G</span><br />
|
||
<span class="medgenPMjournal">Br J Surg</span>
|
||
2024 May 3;111(5)
|
||
doi: 10.1093/bjs/znae070.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38722804" target="_blank">38722804</a><a href="/pmc/articles/PMC11081080" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gastric%20adenocarcinoma%20and%20proximal%20polyposis%20of%20the%20stomach%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
||
<div class="portlet mgSection" id="ID_113">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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</div>
|
||
|
||
<div class="portlet mgSection" id="ID_106">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C4749917%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (14)</a></li>
|
||
<li><a href="/gtr/tests?term=C4749917%5bDISCUI%5d&filter=method%3A2%5F18" target="_blank">Mutation scanning of select exons (4)</a></li>
|
||
<li><a href="/gtr/tests?term=C4749917%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (13)</a></li>
|
||
<li><a href="/gtr/tests?term=C4749917%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (2)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C4749917%5bDISCUI%5d" target="_blank">See all (21)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_119">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=619182" target="_blank">OMIM</a></li><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=314022" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Gastric%20adenocarcinoma%20and%20proximal%20polyposis%20of%20the%20stomach" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22gastric%20adenocarcinoma%20and%20proximal%20polyposis%20of%20the%20stomach%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Gastric%20adenocarcinoma%20and%20proximal%20polyposis%20of%20the%20stomach%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.acmg.net/ACMG/UploadedPDFS/PDFDocuments/Familial-Adenomatous-Polyposis-ACT-Sheet.aspx">ACMG ACT, 2019</a><div>American College of Medical Genetics and Genomics, Genomic Testing (Secondary Findings) ACT Sheet, APC Pathogenic Variants (Familial Adenomatous Polyposis [FAP]), 2019</div></li></ul></div>
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