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<meta name="keywords" content="C4538355, acromegaly due to pituitary adenoma 1, aip, familial isolated pituitary adenoma syndrome, growth hormone secreting pituitary adenoma 1, isolated familial somatotropinoma, neoplastic process, pagh1, pita1, pituitary adenoma 1, growth hormone-secreting, pituitary adenoma 1, multiple types, pituitary adenoma 1, multiple types, autosomal dominant, somatic mutation, pituitary adenoma predisposition, pituitary adenoma predisposition, autosomal dominant, somatic mutation, pituitary adenoma, familial isolated, pituitary adenoma, growth hormone-secreting, pituitary adenoma, growth hormone-secreting, 1, pituitary adenoma, growth hormone-secreting, type 1, pituitary tumor, growth hormone-secreting, somatic, somatotroph adenoma, somatotrophinoma, familial, somatotropinoma, familial isolated, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="AIP familial isolated pituitary adenoma (AIP-FIPA) is characterized by an increased risk of pituitary neuroendocrine tumors (PitNETs, also known as pituitary adenomas), including growth hormone (GH)-secreting PitNETs (somatotropinomas), prolactin-secreting PitNETs (prolactinomas), GH and prolactin cosecreting PitNETs (somatomammotropinomas), and clinically nonfunctioning PitNETs (NF-PitNETs). Rarely, thyroid-stimulating hormone (TSH)-secreting PitNETs (thyrotropinomas) are observed. Clinical findings result from excess hormone secretion, lack of hormone secretion, and/or mass effects (e.g., headaches, visual field loss). Within the same family, PitNETs can be of the same or different type. Age of diagnosis in AIP-FIPA is usually in the second or third decade." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=1618709
|
||
ConceptID=C4538355
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Somatotroph adenoma<span class="h1sub">(PITA1)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1618709</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C4538355</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>ACROMEGALY DUE TO PITUITARY ADENOMA 1; ISOLATED FAMILIAL SOMATOTROPINOMA; PITA1; PITUITARY ADENOMA 1, MULTIPLE TYPES; Pituitary adenoma, growth hormone-secreting; Pituitary tumor, growth hormone-secreting, somatic; SOMATOTROPHINOMA, FAMILIAL</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="AIP - ID: 9049 - NCBI Gene" href="/gene/9049" class="medgenPMinfo">AIP</a> (11q13.2)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0007052" target="_blank">MONDO:0007052</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/102200" target="_blank">102200</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_101">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Disease_characteristics">Disease characteristics</h1><a sid="101" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="excerpt">Excerpted from the <i>GeneReview: </i><a href="/books/NBK97965" target="_blank">AIP Familial Isolated Pituitary Adenomas</a></div><div>AIP familial isolated pituitary adenoma (AIP-FIPA) is characterized by an increased risk of pituitary neuroendocrine tumors (PitNETs, also known as pituitary adenomas), including growth hormone (GH)-secreting PitNETs (somatotropinomas), prolactin-secreting PitNETs (prolactinomas), GH and prolactin cosecreting PitNETs (somatomammotropinomas), and clinically nonfunctioning PitNETs (NF-PitNETs). Rarely, thyroid-stimulating hormone (TSH)-secreting PitNETs (thyrotropinomas) are observed. Clinical findings result from excess hormone secretion, lack of hormone secretion, and/or mass effects (e.g., headaches, visual field loss). Within the same family, PitNETs can be of the same or different type. Age of diagnosis in AIP-FIPA is usually in the second or third decade. [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div><div class="spaceAbove"><strong>Full text of <i>GeneReview</i> (by section):</strong><br /><a class="medgenPMinfo" href="/books/NBK97965#ipa.Summary" target="NBK97965">Summary</a> | <a class="medgenPMinfo" href="/books/NBK97965#ipa.Diagnosis" target="NBK97965">Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK97965#ipa.Clinical_Characteristics" target="NBK97965">Clinical Characteristics</a> | <a class="medgenPMinfo" href="/books/NBK97965#ipa.Genetically_Related_Allelic_Disorder" target="NBK97965">Genetically Related (Allelic) Disorders</a> | <a class="medgenPMinfo" href="/books/NBK97965#ipa.Differential_Diagnosis" target="NBK97965">Differential Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK97965#ipa.Management" target="NBK97965">Management</a> | <a class="medgenPMinfo" href="/books/NBK97965#ipa.Genetic_Counseling" target="NBK97965">Genetic Counseling</a> | <a class="medgenPMinfo" href="/books/NBK97965#ipa.Resources" target="NBK97965">Resources</a> | <a class="medgenPMinfo" href="/books/NBK97965#ipa.Molecular_Genetics" target="NBK97965">Molecular Genetics</a> | <a class="medgenPMinfo" href="/books/NBK97965#ipa.Chapter_Notes" target="NBK97965">Chapter Notes</a> | <a class="medgenPMinfo" href="/books/NBK97965#ipa.References" target="NBK97965">References</a></div><div class="spaceAbove"><strong>Authors:</strong><br />
|
||
Márta Korbonits | Laura C Hernández-Ramírez <a href="/books/NBK97965" target="NBK97965" title="NCBI Bookshelf: AIP Familial Isolated Pituitary Adenomas">view full author information</a></div></div>
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||
</div>
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||
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||
<div class="portlet mgSection" id="ID_117">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_description">Additional description</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From OMIM</strong><br />Mutations in the AIP gene have been found predominantly in growth hormone (GH)-secreting adenomas, but have also been found in adrenocorticotropic hormone (ACTH)-secreting, thyroid hormone (TSH)-secreting, and prolactin (PRL)-secreting pituitary tumors.
|
||
Pituitary adenomas are benign monoclonal neoplasms of the anterior pituitary gland, accounting for approximately 15% of intracranial tumors. Growth hormone (139250)-secreting adenomas, also known as somatotropinomas, which clinically result in acromegaly, comprise about 20% of all pituitary tumors and are the second most common hormone-secreting pituitary tumor after prolactin (176760)-secreting tumors, which account for 40 to 45% of pituitary tumors. ACTH-secreting tumors, which result in Cushing disease, and thyrotropin (TSHB; 188540)-secreting tumors are much less common. Nonsecreting pituitary tumors, which account for about 33%, can cause symptoms due to local compressive effects of tumor growth (Vierimaa et al., 2006; Georgitsi et al., 2007; Horvath and Stratakis, 2008).
|
||
Acromegaly is characterized by coarse facial features, protruding jaw, and enlarged extremities (Vierimaa et al., 2006). Familial isolated somatotropinoma (FIS) is defined as the occurrence of at least 2 cases of acromegaly or gigantism in a family that does not exhibit features of other endocrine syndromes. FIS patients tend to have onset about 4 to 10 years earlier than patients with sporadic disease (Gadelha et al., 1999; Horvath and Stratakis, 2008).
|
||
Cushing disease is characterized by central obesity, moon facies, diabetes, 'buffalo hump,' hypertension, fatigue, easy bruising, depression, and reproductive disorders. Cushing disease is associated with increased morbidity and mortality, mainly due to cardiovascular or cerebrovascular disease and infections (summary by Perez-Rivas et al., 2015).
|
||
Familial isolated pituitary adenoma (FIPA) and pituitary adenoma predisposition (PAP) are terms referring to families in which 2 or more individuals develop pituitary tumors. Within a family, tumor types can be heterogeneous, with members of the same family having GH-secreting, prolactin-secreting, ACTH-secreting, or nonsecreting adenomas; in contrast, some families are homogeneous with regard to tumor type. Familial isolated somatotropinoma refers specifically to GH-secreting tumors and is usually associated with an acromegaly phenotype. Thus, FIS is a subset of FIPA or PAP (Toledo et al., 2007).
|
||
Schlechte (2003) discussed prolactinoma in general terms as a clinical, diagnostic, and therapeutic problem.
|
||
Genetic Heterogeneity of Pituitary Adenomas
|
||
Also see pituitary adenoma-2 (PITA2; 300943), caused by mutation in the GPR101 gene (300393); pituitary adenoma-3 (PITA3; 617686), caused by somatic activating mutations in the GNAS1 gene (139320); pituitary adenoma-4 (PITA4; 219090), caused by somatic mutation in the USP8 gene (603158); and pituitary adenoma-5 (PITA5; 617540), caused by mutation in the CDH23 gene (605516).
|
||
Patients with the chromosome Xq26.3 microduplication syndrome (300942) have growth hormone-secreting adenomas.
|
||
Familial acromegaly can also occur in association with multiple endocrine neoplasia type I (MEN1; 131100), Carney complex (CNC1; 160980), and the McCune-Albright syndrome (174800).
|
||
Rostomyan et al. (2015) performed a retrospective analysis of 208 patients with pituitary gigantism due to pituitary adenoma or hyperplasia. Most patients (78.4%) were male, and the median onset of rapid growth was 13 years of age for boys and 11 years for girls. Of the 143 patients who consented to genetic testing, 29% had AIP mutations, and microduplication at Xq26.3 (XLAG; 300942) was present in 2 familial isolated pituitary adenoma kindreds and in 10 sporadic patients. Rostomyan et al. (2015) noted that no genetic etiology was identified in more than 50% of the cases, and that the genetically unexplained cases showed more aggressive disease in terms of invasion, hormone levels, and lower control rates. <a target="_blank" href="http://www.omim.org/entry/102200">http://www.omim.org/entry/102200</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_45933"><div><strong>Pituitary adenoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>45933</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0032000</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A benign epithelial tumor derived from intrinsic cells of the adenohypophysis (anterior pituitary).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/45933">Feature record</a> | <a href="/medgen?term=%22Pituitary%20adenoma%22%5BClinical%20Features%5D%20OR%2045933%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_10936"><div><strong>Prolactin-producing pituitary gland adenoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>10936</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0033375</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">AIP familial isolated pituitary adenoma (AIP-FIPA) is characterized by an increased risk of pituitary neuroendocrine tumors (PitNETs, also known as pituitary adenomas), including growth hormone (GH)-secreting PitNETs (somatotropinomas), prolactin-secreting PitNETs (prolactinomas), GH and prolactin cosecreting PitNETs (somatomammotropinomas), and clinically nonfunctioning PitNETs (NF-PitNETs). Rarely, thyroid-stimulating hormone (TSH)-secreting PitNETs (thyrotropinomas) are observed. Clinical findings result from excess hormone secretion, lack of hormone secretion, and/or mass effects (e.g., headaches, visual field loss). Within the same family, PitNETs can be of the same or different type. Age of diagnosis in AIP-FIPA is usually in the second or third decade.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/10936">Feature record</a> | <a href="/medgen?term=%22Prolactin-producing%20pituitary%20gland%20adenoma%22%5BClinical%20Features%5D%20OR%2010936%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_866320"><div><strong>Pituitary growth hormone cell adenoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>866320</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4018860</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A type of pituitary adenoma that produces growth hormone.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/866320">Feature record</a> | <a href="/medgen?term=%22Pituitary%20growth%20hormone%20cell%20adenoma%22%5BClinical%20Features%5D%20OR%20866320%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_56379"><div><strong>Irregular menstruation</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>56379</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0156404</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Abnormally high variation in the amount of time between periods.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/56379">Feature record</a> | <a href="/medgen?term=%22Irregular%20menstruation%22%5BClinical%20Features%5D%20OR%2056379%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_6969"><div><strong>Hypertensive disorder</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>6969</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0020538</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The presence of chronic increased pressure in the systemic arterial system.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/6969">Feature record</a> | <a href="/medgen?term=%22Hypertensive%20disorder%22%5BClinical%20Features%5D%20OR%206969%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_57442"><div><strong>Left ventricular hypertrophy</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>57442</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0149721</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Enlargement or increased size of the heart left ventricle.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/57442">Feature record</a> | <a href="/medgen?term=%22Left%20ventricular%20hypertrophy%22%5BClinical%20Features%5D%20OR%2057442%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_209232"><div><strong>Cardiomyopathy</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>209232</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0878544</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A myocardial disorder in which the heart muscle is structurally and functionally abnormal, in the absence of coronary artery disease, hypertension, valvular disease and congenital heart disease sufficient to cause the observed myocardial abnormality.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/209232">Feature record</a> | <a href="/medgen?term=%22Cardiomyopathy%22%5BClinical%20Features%5D%20OR%20209232%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1789172"><div><strong>Acral overgrowth</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1789172</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1735881</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Excessive growth of hands and feet (predominantly due to soft tissue swelling). Typical manifestations include shoe size increase, foot enlargement, glove tightness, and hand enlargement.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1789172">Feature record</a> | <a href="/medgen?term=%22Acral%20overgrowth%22%5BClinical%20Features%5D%20OR%201789172%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1702649"><div><strong>Increased circulating prolactin concentration</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1702649</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5200994</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The presence of abnormally increased levels of prolactin in the blood. Prolactin is a peptide hormone produced by the anterior pituitary gland that plays a role in breast development and lactation during pregnancy.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1702649">Feature record</a> | <a href="/medgen?term=%22Increased%20circulating%20prolactin%20concentration%22%5BClinical%20Features%5D%20OR%201702649%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_335284"><div><strong>Coarse facial features</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>335284</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1845847</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Absence of fine and sharp appearance of brows, nose, lips, mouth, and chin, usually because of rounded and heavy features or thickened skin with or without thickening of subcutaneous and bony tissues.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/335284">Feature record</a> | <a href="/medgen?term=%22Coarse%20facial%20features%22%5BClinical%20Features%5D%20OR%20335284%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_66732"><div><strong>Elevated circulating growth hormone concentration</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>66732</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0235986</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Acromegaly is a condition resulting from overproduction of growth hormone by the pituitary gland in persons with closed epiphyses, and consists chiefly in the enlargement of the distal parts of the body. The circumference of the skull increases, the nose becomes broad, the tongue becomes enlarged, the facial features become coarsened, the mandible grows excessively, and the teeth become separated. The fingers and toes grow chiefly in thickness.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/66732">Feature record</a> | <a href="/medgen?term=%22Elevated%20circulating%20growth%20hormone%20concentration%22%5BClinical%20Features%5D%20OR%2066732%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_390982"><div><strong>Increased circulating insulin-like growth factor 1 concentration</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>390982</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2676198</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An elevated level of insulin-like growth factor 1 (IGF1) in the blood circulation.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/390982">Feature record</a> | <a href="/medgen?term=%22Increased%20circulating%20insulin-like%20growth%20factor%201%20concentration%22%5BClinical%20Features%5D%20OR%20390982%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_115998"><div><strong>Galactorrhea not associated with childbirth</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>115998</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0235660</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Spontaneous flow of milk from the breast, unassociated with childbirth or nursing.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/115998">Feature record</a> | <a href="/medgen?term=%22Galactorrhea%20not%20associated%20with%20childbirth%22%5BClinical%20Features%5D%20OR%20115998%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of head or neck</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_335284" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Coarse facial features</a></span></li></ul></li><li><span class="TLline">Abnormality of the breast</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_115998" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Galactorrhea not associated with childbirth</a></span></li></ul></li><li><span class="TLline">Abnormality of the cardiovascular system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_209232" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cardiomyopathy</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_6969" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypertensive disorder</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_57442" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Left ventricular hypertrophy</a></span></li></ul></li><li><span class="TLline">Abnormality of the endocrine system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_66732" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Elevated circulating growth hormone concentration</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_390982" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Increased circulating insulin-like growth factor 1 concentration</a></span></li></ul></li><li><span class="TLline">Abnormality of the genitourinary system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_56379" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Irregular menstruation</a></span></li></ul></li><li><span class="TLline">Abnormality of the nervous system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1702649" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Increased circulating prolactin concentration</a></span></li></ul></li><li><span class="TLline">Growth abnormality</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1789172" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Acral overgrowth</a></span></li></ul></li><li><span class="TLline">Neoplasm</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_45933" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pituitary adenoma</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_866320" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pituitary growth hormone cell adenoma</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_10936" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Prolactin-producing pituitary gland adenoma</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37579837">Position statement on the diagnosis and management of acromegaly: The French National Diagnosis and Treatment Protocol (NDTP).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brue T,
|
||
Rahabi H,
|
||
Barry A,
|
||
Barlier A,
|
||
Bertherat J,
|
||
Borson-Chazot F,
|
||
Castinetti F,
|
||
Cazabat L,
|
||
Chabre O,
|
||
Chevalier N,
|
||
Christin-Maitre S,
|
||
Cortet C,
|
||
Drui D,
|
||
Kamenicky P,
|
||
Lançon C,
|
||
Lioté F,
|
||
Pellegrini I,
|
||
Reynaud R,
|
||
Salenave S,
|
||
Tauveron I,
|
||
Touraine P,
|
||
Vantyghem MC,
|
||
Vergès B,
|
||
Vezzosi D,
|
||
Villa C,
|
||
Raverot G,
|
||
Coutant R,
|
||
Chanson P,
|
||
Albarel F</span><br />
|
||
<span class="medgenPMjournal">Ann Endocrinol (Paris)</span>
|
||
2023 Dec;84(6):697-710.
|
||
Epub 2023 Aug 12
|
||
doi: 10.1016/j.ando.2023.08.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37579837" target="_blank">37579837</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33796079">Pasireotide in the Personalized Treatment of Acromegaly.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Puig-Domingo M,
|
||
Bernabéu I,
|
||
Picó A,
|
||
Biagetti B,
|
||
Gil J,
|
||
Alvarez-Escolá C,
|
||
Jordà M,
|
||
Marques-Pamies M,
|
||
Soldevila B,
|
||
Gálvez MA,
|
||
Cámara R,
|
||
Aller J,
|
||
Lamas C,
|
||
Marazuela M</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2021;12:648411.
|
||
Epub 2021 Mar 16
|
||
doi: 10.3389/fendo.2021.648411.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33796079" target="_blank">33796079</a><a href="/pmc/articles/PMC8008639" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26437214">LIMITATIONS OF CURRENT APPROACHES FOR THE TREATMENT OF ACROMEGALY.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shanik MH</span><br />
|
||
<span class="medgenPMjournal">Endocr Pract</span>
|
||
2016 Feb;22(2):210-9.
|
||
Epub 2015 Oct 5
|
||
doi: 10.4158/EP15825.RA.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26437214" target="_blank">26437214</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22somatotroph%20adenoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (8)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37427703">A Comprehensive View(COUP D'OEIL) of Brain Tumors from Eastern India.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Paul P,
|
||
Banerjee M</span><br />
|
||
<span class="medgenPMjournal">World Neurosurg</span>
|
||
2023 Jul;175:e1237-e1245.
|
||
Epub 2023 Apr 30
|
||
doi: 10.1016/j.wneu.2023.04.104.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37427703" target="_blank">37427703</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32930785">Intensity-modulated Radiotherapy for Pituitary Somatotroph Adenomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lian X,
|
||
Shen J,
|
||
Gu Z,
|
||
Yan J,
|
||
Sun S,
|
||
Hou X,
|
||
You H,
|
||
Xing B,
|
||
Zhu H,
|
||
Shen J,
|
||
Zhang F</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2020 Dec 1;105(12)
|
||
doi: 10.1210/clinem/dgaa651.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32930785" target="_blank">32930785</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31368083">Mammosomatotroph and mixed somatotroph-lactotroph adenoma in acromegaly: a retrospective study with long-term follow-up.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lv L,
|
||
Jiang Y,
|
||
Yin S,
|
||
Hu Y,
|
||
Chen C,
|
||
Ma W,
|
||
Jiang S,
|
||
Zhou P</span><br />
|
||
<span class="medgenPMjournal">Endocrine</span>
|
||
2019 Nov;66(2):310-318.
|
||
Epub 2019 Jul 31
|
||
doi: 10.1007/s12020-019-02029-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31368083" target="_blank">31368083</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28766057">Overview of the 2017 WHO Classification of Pituitary Tumors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mete O,
|
||
Lopes MB</span><br />
|
||
<span class="medgenPMjournal">Endocr Pathol</span>
|
||
2017 Sep;28(3):228-243.
|
||
doi: 10.1007/s12022-017-9498-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28766057" target="_blank">28766057</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26437214">LIMITATIONS OF CURRENT APPROACHES FOR THE TREATMENT OF ACROMEGALY.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shanik MH</span><br />
|
||
<span class="medgenPMjournal">Endocr Pract</span>
|
||
2016 Feb;22(2):210-9.
|
||
Epub 2015 Oct 5
|
||
doi: 10.4158/EP15825.RA.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26437214" target="_blank">26437214</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Somatotroph%20adenoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (36)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37579837">Position statement on the diagnosis and management of acromegaly: The French National Diagnosis and Treatment Protocol (NDTP).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brue T,
|
||
Rahabi H,
|
||
Barry A,
|
||
Barlier A,
|
||
Bertherat J,
|
||
Borson-Chazot F,
|
||
Castinetti F,
|
||
Cazabat L,
|
||
Chabre O,
|
||
Chevalier N,
|
||
Christin-Maitre S,
|
||
Cortet C,
|
||
Drui D,
|
||
Kamenicky P,
|
||
Lançon C,
|
||
Lioté F,
|
||
Pellegrini I,
|
||
Reynaud R,
|
||
Salenave S,
|
||
Tauveron I,
|
||
Touraine P,
|
||
Vantyghem MC,
|
||
Vergès B,
|
||
Vezzosi D,
|
||
Villa C,
|
||
Raverot G,
|
||
Coutant R,
|
||
Chanson P,
|
||
Albarel F</span><br />
|
||
<span class="medgenPMjournal">Ann Endocrinol (Paris)</span>
|
||
2023 Dec;84(6):697-710.
|
||
Epub 2023 Aug 12
|
||
doi: 10.1016/j.ando.2023.08.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37579837" target="_blank">37579837</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35365312">Nonfunctioning Pituitary Lesions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brownlee BP,
|
||
Mann D,
|
||
Glenn C,
|
||
McKinney KA</span><br />
|
||
<span class="medgenPMjournal">Otolaryngol Clin North Am</span>
|
||
2022 Apr;55(2):343-350.
|
||
doi: 10.1016/j.otc.2021.12.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35365312" target="_blank">35365312</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34607164">Growth hormone secreting pituitary carcinomas: Case report and review of literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vekaria S,
|
||
Chen F,
|
||
Zan E,
|
||
William C,
|
||
Sen C,
|
||
Lebowitz R,
|
||
Zagzag D,
|
||
Warren FA,
|
||
Brandler TC,
|
||
Agrawal N</span><br />
|
||
<span class="medgenPMjournal">Growth Horm IGF Res</span>
|
||
2021 Oct-Dec;60-61:101430.
|
||
Epub 2021 Sep 29
|
||
doi: 10.1016/j.ghir.2021.101430.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34607164" target="_blank">34607164</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26437214">LIMITATIONS OF CURRENT APPROACHES FOR THE TREATMENT OF ACROMEGALY.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shanik MH</span><br />
|
||
<span class="medgenPMjournal">Endocr Pract</span>
|
||
2016 Feb;22(2):210-9.
|
||
Epub 2015 Oct 5
|
||
doi: 10.4158/EP15825.RA.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26437214" target="_blank">26437214</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1521516">Pituitary gigantism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Daughaday WH</span><br />
|
||
<span class="medgenPMjournal">Endocrinol Metab Clin North Am</span>
|
||
1992 Sep;21(3):633-47.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1521516" target="_blank">1521516</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Somatotroph%20adenoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (45)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37735314">Clinical and prognostic significance of granulation patterns in somatotroph adenomas/tumors of the pituitary: a meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vuong HG,
|
||
Dunn IF</span><br />
|
||
<span class="medgenPMjournal">Pituitary</span>
|
||
2023 Dec;26(6):653-659.
|
||
Epub 2023 Sep 21
|
||
doi: 10.1007/s11102-023-01353-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37735314" target="_blank">37735314</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37579837">Position statement on the diagnosis and management of acromegaly: The French National Diagnosis and Treatment Protocol (NDTP).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brue T,
|
||
Rahabi H,
|
||
Barry A,
|
||
Barlier A,
|
||
Bertherat J,
|
||
Borson-Chazot F,
|
||
Castinetti F,
|
||
Cazabat L,
|
||
Chabre O,
|
||
Chevalier N,
|
||
Christin-Maitre S,
|
||
Cortet C,
|
||
Drui D,
|
||
Kamenicky P,
|
||
Lançon C,
|
||
Lioté F,
|
||
Pellegrini I,
|
||
Reynaud R,
|
||
Salenave S,
|
||
Tauveron I,
|
||
Touraine P,
|
||
Vantyghem MC,
|
||
Vergès B,
|
||
Vezzosi D,
|
||
Villa C,
|
||
Raverot G,
|
||
Coutant R,
|
||
Chanson P,
|
||
Albarel F</span><br />
|
||
<span class="medgenPMjournal">Ann Endocrinol (Paris)</span>
|
||
2023 Dec;84(6):697-710.
|
||
Epub 2023 Aug 12
|
||
doi: 10.1016/j.ando.2023.08.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37579837" target="_blank">37579837</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36790521">Modern approach to resistant acromegaly.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Giustina A,
|
||
di Filippo L,
|
||
Uygur MM,
|
||
Frara S</span><br />
|
||
<span class="medgenPMjournal">Endocrine</span>
|
||
2023 May;80(2):303-307.
|
||
Epub 2023 Feb 15
|
||
doi: 10.1007/s12020-023-03317-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36790521" target="_blank">36790521</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33796079">Pasireotide in the Personalized Treatment of Acromegaly.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Puig-Domingo M,
|
||
Bernabéu I,
|
||
Picó A,
|
||
Biagetti B,
|
||
Gil J,
|
||
Alvarez-Escolá C,
|
||
Jordà M,
|
||
Marques-Pamies M,
|
||
Soldevila B,
|
||
Gálvez MA,
|
||
Cámara R,
|
||
Aller J,
|
||
Lamas C,
|
||
Marazuela M</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2021;12:648411.
|
||
Epub 2021 Mar 16
|
||
doi: 10.3389/fendo.2021.648411.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33796079" target="_blank">33796079</a><a href="/pmc/articles/PMC8008639" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26437214">LIMITATIONS OF CURRENT APPROACHES FOR THE TREATMENT OF ACROMEGALY.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shanik MH</span><br />
|
||
<span class="medgenPMjournal">Endocr Pract</span>
|
||
2016 Feb;22(2):210-9.
|
||
Epub 2015 Oct 5
|
||
doi: 10.4158/EP15825.RA.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26437214" target="_blank">26437214</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Somatotroph%20adenoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (31)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37735314">Clinical and prognostic significance of granulation patterns in somatotroph adenomas/tumors of the pituitary: a meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vuong HG,
|
||
Dunn IF</span><br />
|
||
<span class="medgenPMjournal">Pituitary</span>
|
||
2023 Dec;26(6):653-659.
|
||
Epub 2023 Sep 21
|
||
doi: 10.1007/s11102-023-01353-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37735314" target="_blank">37735314</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36790521">Modern approach to resistant acromegaly.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Giustina A,
|
||
di Filippo L,
|
||
Uygur MM,
|
||
Frara S</span><br />
|
||
<span class="medgenPMjournal">Endocrine</span>
|
||
2023 May;80(2):303-307.
|
||
Epub 2023 Feb 15
|
||
doi: 10.1007/s12020-023-03317-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36790521" target="_blank">36790521</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34607164">Growth hormone secreting pituitary carcinomas: Case report and review of literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vekaria S,
|
||
Chen F,
|
||
Zan E,
|
||
William C,
|
||
Sen C,
|
||
Lebowitz R,
|
||
Zagzag D,
|
||
Warren FA,
|
||
Brandler TC,
|
||
Agrawal N</span><br />
|
||
<span class="medgenPMjournal">Growth Horm IGF Res</span>
|
||
2021 Oct-Dec;60-61:101430.
|
||
Epub 2021 Sep 29
|
||
doi: 10.1016/j.ghir.2021.101430.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34607164" target="_blank">34607164</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32930785">Intensity-modulated Radiotherapy for Pituitary Somatotroph Adenomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lian X,
|
||
Shen J,
|
||
Gu Z,
|
||
Yan J,
|
||
Sun S,
|
||
Hou X,
|
||
You H,
|
||
Xing B,
|
||
Zhu H,
|
||
Shen J,
|
||
Zhang F</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2020 Dec 1;105(12)
|
||
doi: 10.1210/clinem/dgaa651.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32930785" target="_blank">32930785</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31368083">Mammosomatotroph and mixed somatotroph-lactotroph adenoma in acromegaly: a retrospective study with long-term follow-up.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lv L,
|
||
Jiang Y,
|
||
Yin S,
|
||
Hu Y,
|
||
Chen C,
|
||
Ma W,
|
||
Jiang S,
|
||
Zhou P</span><br />
|
||
<span class="medgenPMjournal">Endocrine</span>
|
||
2019 Nov;66(2):310-318.
|
||
Epub 2019 Jul 31
|
||
doi: 10.1007/s12020-019-02029-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31368083" target="_blank">31368083</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Somatotroph%20adenoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (25)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36790521">Modern approach to resistant acromegaly.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Giustina A,
|
||
di Filippo L,
|
||
Uygur MM,
|
||
Frara S</span><br />
|
||
<span class="medgenPMjournal">Endocrine</span>
|
||
2023 May;80(2):303-307.
|
||
Epub 2023 Feb 15
|
||
doi: 10.1007/s12020-023-03317-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36790521" target="_blank">36790521</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34607164">Growth hormone secreting pituitary carcinomas: Case report and review of literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vekaria S,
|
||
Chen F,
|
||
Zan E,
|
||
William C,
|
||
Sen C,
|
||
Lebowitz R,
|
||
Zagzag D,
|
||
Warren FA,
|
||
Brandler TC,
|
||
Agrawal N</span><br />
|
||
<span class="medgenPMjournal">Growth Horm IGF Res</span>
|
||
2021 Oct-Dec;60-61:101430.
|
||
Epub 2021 Sep 29
|
||
doi: 10.1016/j.ghir.2021.101430.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34607164" target="_blank">34607164</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33074402">Clinical, biological, radiological, and pathological comparison of sparsely and densely granulated somatotroph adenomas: a single center experience from a cohort of 131 patients with acromegaly.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Swanson AA,
|
||
Erickson D,
|
||
Donegan DM,
|
||
Jenkins SM,
|
||
Van Gompel JJ,
|
||
Atkinson JLD,
|
||
Erickson BJ,
|
||
Giannini C</span><br />
|
||
<span class="medgenPMjournal">Pituitary</span>
|
||
2021 Apr;24(2):192-206.
|
||
Epub 2020 Oct 19
|
||
doi: 10.1007/s11102-020-01096-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33074402" target="_blank">33074402</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32930785">Intensity-modulated Radiotherapy for Pituitary Somatotroph Adenomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lian X,
|
||
Shen J,
|
||
Gu Z,
|
||
Yan J,
|
||
Sun S,
|
||
Hou X,
|
||
You H,
|
||
Xing B,
|
||
Zhu H,
|
||
Shen J,
|
||
Zhang F</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2020 Dec 1;105(12)
|
||
doi: 10.1210/clinem/dgaa651.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32930785" target="_blank">32930785</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31368083">Mammosomatotroph and mixed somatotroph-lactotroph adenoma in acromegaly: a retrospective study with long-term follow-up.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lv L,
|
||
Jiang Y,
|
||
Yin S,
|
||
Hu Y,
|
||
Chen C,
|
||
Ma W,
|
||
Jiang S,
|
||
Zhou P</span><br />
|
||
<span class="medgenPMjournal">Endocrine</span>
|
||
2019 Nov;66(2):310-318.
|
||
Epub 2019 Jul 31
|
||
doi: 10.1007/s12020-019-02029-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31368083" target="_blank">31368083</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Somatotroph%20adenoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (37)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/33790868">Epithelial-Mesenchymal Transition in the Resistance to Somatostatin Receptor Ligands in Acromegaly.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gil J,
|
||
Jordà M,
|
||
Soldevila B,
|
||
Puig-Domingo M</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2021;12:646210.
|
||
Epub 2021 Mar 15
|
||
doi: 10.3389/fendo.2021.646210.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33790868" target="_blank">33790868</a><a href="/pmc/articles/PMC8006574" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Somatotroph%20adenoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
||
<div class="portlet mgSection" id="ID_113">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_106">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C4538355%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (24)</a></li>
|
||
<li><a href="/gtr/tests?term=C4538355%5bDISCUI%5d&filter=method%3A2%5F18" target="_blank">Mutation scanning of select exons (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C4538355%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (33)</a></li>
|
||
<li><a href="/gtr/tests?term=C4538355%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (4)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C4538355%5bDISCUI%5d" target="_blank">See all (36)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_119">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=102200" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Somatotroph%20adenoma" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22somatotroph%20adenoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Somatotroph%20adenoma%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_115">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=605555" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=9049[geneid]" target="_blank">View AIP variations in ClinVar</a></li><li><a href="/nuccore/212549720" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=102200" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_116">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Pituitary+adenoma%2C+growth+hormone-secreting/9117" target="_blank">Genetic Alliance</a></li><li><a href="https://www.malacards.org/card/pituitary_adenoma_1_multiple_types" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Somatotroph%20adenoma" target="_blank">MedlinePlus</a></li></ul></div>
|
||
</div>
|
||
</div>
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Reviews</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Reviews" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pubmed/22720333" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=3" target="_blank"><span class="gene_reviews">GeneReviews</span></a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/clinical?term=Somatotroph%20adenoma" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=3" target="_blank">PubMed Clinical Queries</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed?term=Somatotroph%20adenoma%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=3&linkpostotal=3" target="_blank">Reviews in PubMed</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<!-- MedGen supplemental column ends here -->
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=1618709" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=medgen_gene_diseases&from_uid=1618709" ref="log$=recordlinks">Gene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in NCBI Gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C4538355[DISCUI]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C4538355[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim&from_uid=1618709" ref="log$=recordlinks">OMIM</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related records in OMIM</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim_gene&from_uid=1618709" ref="log$=recordlinks">OMIM(Genes)</a>
|
||
<div class="brieflinkpop offscreen_noflow">OMIM records containing genes associated with phenotypes registered in MedGen</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=1618709" ref="log$=recordlinks">PMC Articles</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in PubMed Central Links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&from_uid=1618709" ref="log$=recordlinks">PubMed</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_bookshelf_cited&from_uid=1618709" ref="log$=recordlinks">PubMed (Bookshelf cited)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Links to PubMed based on citations in GeneReviews and Medical Genetics Summaries</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_genereviews&from_uid=1618709" ref="log$=recordlinks">PubMed (GeneReviews)</a>
|
||
<div class="brieflinkpop offscreen_noflow">GeneReviews in PubMed</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_omim&from_uid=1618709" ref="log$=recordlinks">PubMed (OMIM)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Recent activity</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<div id="HTDisplay" class="">
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<li>
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<a class="text-white" href="https://www.hhs.gov/">HHS</a>
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||
</li>
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<li>
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||
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
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||
</li>
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</ul>
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