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<!--
|
||
UID=864469
|
||
ConceptID=C4016032
|
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-->
|
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, somatic</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>864469</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C4016032</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>NONSMALL CELL LUNG CANCER, RESPONSE TO TYROSINE KINASE INHIBITOR IN, SOMATIC</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>OMIM<span class="superscript">®</span>:</td>
|
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<td><a href="https://omim.org/entry/131550" target="_blank">131550</a></td></tr>
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32186215">Lorlatinib for the treatment of ALK-positive metastatic non-small cell lung cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Choo JR,
|
||
Soo RA</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Anticancer Ther</span>
|
||
2020 Apr;20(4):233-240.
|
||
Epub 2020 Mar 25
|
||
doi: 10.1080/14737140.2020.1744438.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32186215" target="_blank">32186215</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29423594">Treatment of EGFR T790M-Positive Non-Small Cell Lung Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Choo JR,
|
||
Tan CS,
|
||
Soo RA</span><br />
|
||
<span class="medgenPMjournal">Target Oncol</span>
|
||
2018 Apr;13(2):141-156.
|
||
doi: 10.1007/s11523-018-0554-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29423594" target="_blank">29423594</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24857124">Management and future directions in non-small cell lung cancer with known activating mutations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gerber DE,
|
||
Gandhi L,
|
||
Costa DB</span><br />
|
||
<span class="medgenPMjournal">Am Soc Clin Oncol Educ Book</span>
|
||
2014:e353-65.
|
||
doi: 10.14694/EdBook_AM.2014.34.e353.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24857124" target="_blank">24857124</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(nonsmall%20cell%20lung%20cancer%2C%20response%20to%20tyrosine%20kinase%20inhibitor%20in%2C%20somatic)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (19)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38407352">Impact of Tumor-intrinsic Molecular Features on Survival and Acquired Tyrosine Kinase Inhibitor Resistance in ALK-positive NSCLC.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nakazawa M,
|
||
Harada G,
|
||
Ghanem P,
|
||
Bubie A,
|
||
Kiedrowski LA,
|
||
Murray JC,
|
||
Marrone KA,
|
||
Scott SC,
|
||
Houseknecht S,
|
||
Falcon CJ,
|
||
Evans P,
|
||
Feliciano J,
|
||
Hann CL,
|
||
Ettinger DS,
|
||
Smith KN,
|
||
Anagnostou V,
|
||
Forde PM,
|
||
Brahmer JR,
|
||
Levy B,
|
||
Drilon A,
|
||
Lam VK</span><br />
|
||
<span class="medgenPMjournal">Cancer Res Commun</span>
|
||
2024 Mar 14;4(3):786-795.
|
||
doi: 10.1158/2767-9764.CRC-24-0065.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38407352" target="_blank">38407352</a><a href="/pmc/articles/PMC10939006" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35331964">Concurrent TP53 Mutations Facilitate Resistance Evolution in EGFR-Mutant Lung Adenocarcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vokes NI,
|
||
Chambers E,
|
||
Nguyen T,
|
||
Coolidge A,
|
||
Lydon CA,
|
||
Le X,
|
||
Sholl L,
|
||
Heymach JV,
|
||
Nishino M,
|
||
Van Allen EM,
|
||
Jänne PA</span><br />
|
||
<span class="medgenPMjournal">J Thorac Oncol</span>
|
||
2022 Jun;17(6):779-792.
|
||
Epub 2022 Mar 21
|
||
doi: 10.1016/j.jtho.2022.02.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35331964" target="_blank">35331964</a><a href="/pmc/articles/PMC10478031" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32186215">Lorlatinib for the treatment of ALK-positive metastatic non-small cell lung cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Choo JR,
|
||
Soo RA</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Anticancer Ther</span>
|
||
2020 Apr;20(4):233-240.
|
||
Epub 2020 Mar 25
|
||
doi: 10.1080/14737140.2020.1744438.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32186215" target="_blank">32186215</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28285694">SBRT for oligoprogressive oncogene addicted NSCLC.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Basler L,
|
||
Kroeze SG,
|
||
Guckenberger M</span><br />
|
||
<span class="medgenPMjournal">Lung Cancer</span>
|
||
2017 Apr;106:50-57.
|
||
Epub 2017 Feb 6
|
||
doi: 10.1016/j.lungcan.2017.02.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28285694" target="_blank">28285694</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18580100">EGFR assays in lung cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dacic S</span><br />
|
||
<span class="medgenPMjournal">Adv Anat Pathol</span>
|
||
2008 Jul;15(4):241-7.
|
||
doi: 10.1097/PAP.0b013e31817bf5a9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18580100" target="_blank">18580100</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nonsmall%20cell%20lung%20cancer%2C%20response%20to%20tyrosine%20kinase%20inhibitor%20in%2C%20somatic%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (44)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34083237">Modeling Clinical Responses to Targeted Therapies by Patient-Derived Organoids of Advanced Lung Adenocarcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kim SY,
|
||
Kim SM,
|
||
Lim S,
|
||
Lee JY,
|
||
Choi SJ,
|
||
Yang SD,
|
||
Yun MR,
|
||
Kim CG,
|
||
Gu SR,
|
||
Park C,
|
||
Park AY,
|
||
Lim SM,
|
||
Heo SG,
|
||
Kim H,
|
||
Cho BC</span><br />
|
||
<span class="medgenPMjournal">Clin Cancer Res</span>
|
||
2021 Aug 1;27(15):4397-4409.
|
||
Epub 2021 Jun 3
|
||
doi: 10.1158/1078-0432.CCR-20-5026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34083237" target="_blank">34083237</a><a href="/pmc/articles/PMC9401503" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28285694">SBRT for oligoprogressive oncogene addicted NSCLC.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Basler L,
|
||
Kroeze SG,
|
||
Guckenberger M</span><br />
|
||
<span class="medgenPMjournal">Lung Cancer</span>
|
||
2017 Apr;106:50-57.
|
||
Epub 2017 Feb 6
|
||
doi: 10.1016/j.lungcan.2017.02.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28285694" target="_blank">28285694</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21764376">EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yasuda H,
|
||
Kobayashi S,
|
||
Costa DB</span><br />
|
||
<span class="medgenPMjournal">Lancet Oncol</span>
|
||
2012 Jan;13(1):e23-31.
|
||
Epub 2011 Jul 19
|
||
doi: 10.1016/S1470-2045(11)70129-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21764376" target="_blank">21764376</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15118125">EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Paez JG,
|
||
Jänne PA,
|
||
Lee JC,
|
||
Tracy S,
|
||
Greulich H,
|
||
Gabriel S,
|
||
Herman P,
|
||
Kaye FJ,
|
||
Lindeman N,
|
||
Boggon TJ,
|
||
Naoki K,
|
||
Sasaki H,
|
||
Fujii Y,
|
||
Eck MJ,
|
||
Sellers WR,
|
||
Johnson BE,
|
||
Meyerson M</span><br />
|
||
<span class="medgenPMjournal">Science</span>
|
||
2004 Jun 4;304(5676):1497-500.
|
||
Epub 2004 Apr 29
|
||
doi: 10.1126/science.1099314.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15118125" target="_blank">15118125</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15118073">Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lynch TJ,
|
||
Bell DW,
|
||
Sordella R,
|
||
Gurubhagavatula S,
|
||
Okimoto RA,
|
||
Brannigan BW,
|
||
Harris PL,
|
||
Haserlat SM,
|
||
Supko JG,
|
||
Haluska FG,
|
||
Louis DN,
|
||
Christiani DC,
|
||
Settleman J,
|
||
Haber DA</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2004 May 20;350(21):2129-39.
|
||
Epub 2004 Apr 29
|
||
doi: 10.1056/NEJMoa040938.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15118073" target="_blank">15118073</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nonsmall%20cell%20lung%20cancer%2C%20response%20to%20tyrosine%20kinase%20inhibitor%20in%2C%20somatic%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (108)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31715421">RET fusions in solid tumors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li AY,
|
||
McCusker MG,
|
||
Russo A,
|
||
Scilla KA,
|
||
Gittens A,
|
||
Arensmeyer K,
|
||
Mehra R,
|
||
Adamo V,
|
||
Rolfo C</span><br />
|
||
<span class="medgenPMjournal">Cancer Treat Rev</span>
|
||
2019 Dec;81:101911.
|
||
Epub 2019 Oct 30
|
||
doi: 10.1016/j.ctrv.2019.101911.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31715421" target="_blank">31715421</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31454018">Systemic Therapy for Locally Advanced and Metastatic Non-Small Cell Lung Cancer: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Arbour KC,
|
||
Riely GJ</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2019 Aug 27;322(8):764-774.
|
||
doi: 10.1001/jama.2019.11058.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31454018" target="_blank">31454018</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21764376">EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yasuda H,
|
||
Kobayashi S,
|
||
Costa DB</span><br />
|
||
<span class="medgenPMjournal">Lancet Oncol</span>
|
||
2012 Jan;13(1):e23-31.
|
||
Epub 2011 Jul 19
|
||
doi: 10.1016/S1470-2045(11)70129-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21764376" target="_blank">21764376</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15118125">EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Paez JG,
|
||
Jänne PA,
|
||
Lee JC,
|
||
Tracy S,
|
||
Greulich H,
|
||
Gabriel S,
|
||
Herman P,
|
||
Kaye FJ,
|
||
Lindeman N,
|
||
Boggon TJ,
|
||
Naoki K,
|
||
Sasaki H,
|
||
Fujii Y,
|
||
Eck MJ,
|
||
Sellers WR,
|
||
Johnson BE,
|
||
Meyerson M</span><br />
|
||
<span class="medgenPMjournal">Science</span>
|
||
2004 Jun 4;304(5676):1497-500.
|
||
Epub 2004 Apr 29
|
||
doi: 10.1126/science.1099314.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15118125" target="_blank">15118125</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15118073">Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lynch TJ,
|
||
Bell DW,
|
||
Sordella R,
|
||
Gurubhagavatula S,
|
||
Okimoto RA,
|
||
Brannigan BW,
|
||
Harris PL,
|
||
Haserlat SM,
|
||
Supko JG,
|
||
Haluska FG,
|
||
Louis DN,
|
||
Christiani DC,
|
||
Settleman J,
|
||
Haber DA</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2004 May 20;350(21):2129-39.
|
||
Epub 2004 Apr 29
|
||
doi: 10.1056/NEJMoa040938.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15118073" target="_blank">15118073</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nonsmall%20cell%20lung%20cancer%2C%20response%20to%20tyrosine%20kinase%20inhibitor%20in%2C%20somatic%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (135)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35331964">Concurrent TP53 Mutations Facilitate Resistance Evolution in EGFR-Mutant Lung Adenocarcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vokes NI,
|
||
Chambers E,
|
||
Nguyen T,
|
||
Coolidge A,
|
||
Lydon CA,
|
||
Le X,
|
||
Sholl L,
|
||
Heymach JV,
|
||
Nishino M,
|
||
Van Allen EM,
|
||
Jänne PA</span><br />
|
||
<span class="medgenPMjournal">J Thorac Oncol</span>
|
||
2022 Jun;17(6):779-792.
|
||
Epub 2022 Mar 21
|
||
doi: 10.1016/j.jtho.2022.02.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35331964" target="_blank">35331964</a><a href="/pmc/articles/PMC10478031" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34083237">Modeling Clinical Responses to Targeted Therapies by Patient-Derived Organoids of Advanced Lung Adenocarcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kim SY,
|
||
Kim SM,
|
||
Lim S,
|
||
Lee JY,
|
||
Choi SJ,
|
||
Yang SD,
|
||
Yun MR,
|
||
Kim CG,
|
||
Gu SR,
|
||
Park C,
|
||
Park AY,
|
||
Lim SM,
|
||
Heo SG,
|
||
Kim H,
|
||
Cho BC</span><br />
|
||
<span class="medgenPMjournal">Clin Cancer Res</span>
|
||
2021 Aug 1;27(15):4397-4409.
|
||
Epub 2021 Jun 3
|
||
doi: 10.1158/1078-0432.CCR-20-5026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34083237" target="_blank">34083237</a><a href="/pmc/articles/PMC9401503" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31454018">Systemic Therapy for Locally Advanced and Metastatic Non-Small Cell Lung Cancer: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Arbour KC,
|
||
Riely GJ</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2019 Aug 27;322(8):764-774.
|
||
doi: 10.1001/jama.2019.11058.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31454018" target="_blank">31454018</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26068305">Strategies to overcome resistance to tyrosine kinase inhibitors in non-small-cell lung cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Santarpia M,
|
||
Gil N,
|
||
Rosell R</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Clin Pharmacol</span>
|
||
2015;8(4):461-77.
|
||
Epub 2015 Jun 11
|
||
doi: 10.1586/17512433.2015.1055252.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26068305" target="_blank">26068305</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15118125">EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Paez JG,
|
||
Jänne PA,
|
||
Lee JC,
|
||
Tracy S,
|
||
Greulich H,
|
||
Gabriel S,
|
||
Herman P,
|
||
Kaye FJ,
|
||
Lindeman N,
|
||
Boggon TJ,
|
||
Naoki K,
|
||
Sasaki H,
|
||
Fujii Y,
|
||
Eck MJ,
|
||
Sellers WR,
|
||
Johnson BE,
|
||
Meyerson M</span><br />
|
||
<span class="medgenPMjournal">Science</span>
|
||
2004 Jun 4;304(5676):1497-500.
|
||
Epub 2004 Apr 29
|
||
doi: 10.1126/science.1099314.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15118125" target="_blank">15118125</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nonsmall%20cell%20lung%20cancer%2C%20response%20to%20tyrosine%20kinase%20inhibitor%20in%2C%20somatic%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (93)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35331964">Concurrent TP53 Mutations Facilitate Resistance Evolution in EGFR-Mutant Lung Adenocarcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vokes NI,
|
||
Chambers E,
|
||
Nguyen T,
|
||
Coolidge A,
|
||
Lydon CA,
|
||
Le X,
|
||
Sholl L,
|
||
Heymach JV,
|
||
Nishino M,
|
||
Van Allen EM,
|
||
Jänne PA</span><br />
|
||
<span class="medgenPMjournal">J Thorac Oncol</span>
|
||
2022 Jun;17(6):779-792.
|
||
Epub 2022 Mar 21
|
||
doi: 10.1016/j.jtho.2022.02.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35331964" target="_blank">35331964</a><a href="/pmc/articles/PMC10478031" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34083237">Modeling Clinical Responses to Targeted Therapies by Patient-Derived Organoids of Advanced Lung Adenocarcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kim SY,
|
||
Kim SM,
|
||
Lim S,
|
||
Lee JY,
|
||
Choi SJ,
|
||
Yang SD,
|
||
Yun MR,
|
||
Kim CG,
|
||
Gu SR,
|
||
Park C,
|
||
Park AY,
|
||
Lim SM,
|
||
Heo SG,
|
||
Kim H,
|
||
Cho BC</span><br />
|
||
<span class="medgenPMjournal">Clin Cancer Res</span>
|
||
2021 Aug 1;27(15):4397-4409.
|
||
Epub 2021 Jun 3
|
||
doi: 10.1158/1078-0432.CCR-20-5026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34083237" target="_blank">34083237</a><a href="/pmc/articles/PMC9401503" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31454018">Systemic Therapy for Locally Advanced and Metastatic Non-Small Cell Lung Cancer: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Arbour KC,
|
||
Riely GJ</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2019 Aug 27;322(8):764-774.
|
||
doi: 10.1001/jama.2019.11058.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31454018" target="_blank">31454018</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15118125">EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Paez JG,
|
||
Jänne PA,
|
||
Lee JC,
|
||
Tracy S,
|
||
Greulich H,
|
||
Gabriel S,
|
||
Herman P,
|
||
Kaye FJ,
|
||
Lindeman N,
|
||
Boggon TJ,
|
||
Naoki K,
|
||
Sasaki H,
|
||
Fujii Y,
|
||
Eck MJ,
|
||
Sellers WR,
|
||
Johnson BE,
|
||
Meyerson M</span><br />
|
||
<span class="medgenPMjournal">Science</span>
|
||
2004 Jun 4;304(5676):1497-500.
|
||
Epub 2004 Apr 29
|
||
doi: 10.1126/science.1099314.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15118125" target="_blank">15118125</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15118073">Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lynch TJ,
|
||
Bell DW,
|
||
Sordella R,
|
||
Gurubhagavatula S,
|
||
Okimoto RA,
|
||
Brannigan BW,
|
||
Harris PL,
|
||
Haserlat SM,
|
||
Supko JG,
|
||
Haluska FG,
|
||
Louis DN,
|
||
Christiani DC,
|
||
Settleman J,
|
||
Haber DA</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2004 May 20;350(21):2129-39.
|
||
Epub 2004 Apr 29
|
||
doi: 10.1056/NEJMoa040938.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15118073" target="_blank">15118073</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nonsmall%20cell%20lung%20cancer%2C%20response%20to%20tyrosine%20kinase%20inhibitor%20in%2C%20somatic%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (107)</a></div></div>
|
||
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|
||
|
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<div class="portlet mgSection" id="ID_104">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/39576954">Safety and Efficacy of Osimertinib in Patients With Non-Small-Cell Lung Cancer and Uncommon Tumoral Epidermal Growth Factor Receptor Mutations: A Systematic Review and Single-Arm Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Priantti JN,
|
||
Fujiwara Y,
|
||
Aquino de Moraes FC,
|
||
Michelon I,
|
||
Castro C,
|
||
Leighl NB,
|
||
Cavalcante L,
|
||
Addeo A,
|
||
Bar J,
|
||
Horita N,
|
||
Cortellini A,
|
||
Nassar AH,
|
||
Vilbert M,
|
||
Naqash AR</span><br />
|
||
<span class="medgenPMjournal">JCO Precis Oncol</span>
|
||
2024 Nov;8:e2400331.
|
||
Epub 2024 Nov 22
|
||
doi: 10.1200/PO.24.00331.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39576954" target="_blank">39576954</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26573867">Effect of smoking status on progression-free and overall survival in non-small cell lung cancer patients receiving erlotinib or gefitinib: a meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sohn HS,
|
||
Kwon JW,
|
||
Shin S,
|
||
Kim HS,
|
||
Kim H</span><br />
|
||
<span class="medgenPMjournal">J Clin Pharm Ther</span>
|
||
2015 Dec;40(6):661-71.
|
||
Epub 2015 Nov 17
|
||
doi: 10.1111/jcpt.12332.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26573867" target="_blank">26573867</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20028749">Somatic EGFR mutation and gene copy gain as predictive biomarkers for response to tyrosine kinase inhibitors in non-small cell lung cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dahabreh IJ,
|
||
Linardou H,
|
||
Siannis F,
|
||
Kosmidis P,
|
||
Bafaloukos D,
|
||
Murray S</span><br />
|
||
<span class="medgenPMjournal">Clin Cancer Res</span>
|
||
2010 Jan 1;16(1):291-303.
|
||
Epub 2009 Dec 22
|
||
doi: 10.1158/1078-0432.CCR-09-1660.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20028749" target="_blank">20028749</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18804418">Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Linardou H,
|
||
Dahabreh IJ,
|
||
Kanaloupiti D,
|
||
Siannis F,
|
||
Bafaloukos D,
|
||
Kosmidis P,
|
||
Papadimitriou CA,
|
||
Murray S</span><br />
|
||
<span class="medgenPMjournal">Lancet Oncol</span>
|
||
2008 Oct;9(10):962-72.
|
||
Epub 2008 Sep 17
|
||
doi: 10.1016/S1470-2045(08)70206-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18804418" target="_blank">18804418</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nonsmall%20cell%20lung%20cancer%2C%20response%20to%20tyrosine%20kinase%20inhibitor%20in%2C%20somatic%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div></div>
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