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<meta name="keywords" content="C4015951, bone mineral density variation quantitative trait locus, finding, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="" /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Bone mineral density variation quantitative trait locus (Concept Id: C4015951)
- MedGen - NCBI</title>
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<!--
UID=864388
ConceptID=C4015951
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Bone mineral density variation quantitative trait locus</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>864388</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C4015951</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
<td>BONE MINERAL DENSITY VARIATION QUANTITATIVE TRAIT LOCUS</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>OMIM<span class="superscript">®</span>:</td>
<td><a href="https://omim.org/entry/120150" target="_blank">120150</a></td></tr>
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<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/34887591">The power of genetic diversity in genome-wide association studies of lipids.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Graham SE,
Clarke SL,
Wu KH,
Kanoni S,
Zajac GJM,
Ramdas S,
Surakka I,
Ntalla I,
Vedantam S,
Winkler TW,
Locke AE,
Marouli E,
Hwang MY,
Han S,
Narita A,
Choudhury A,
Bentley AR,
Ekoru K,
Verma A,
Trivedi B,
Martin HC,
Hunt KA,
Hui Q,
Klarin D,
Zhu X,
Thorleifsson G,
Helgadottir A,
Gudbjartsson DF,
Holm H,
Olafsson I,
Akiyama M,
Sakaue S,
Terao C,
Kanai M,
Zhou W,
Brumpton BM,
Rasheed H,
Ruotsalainen SE,
Havulinna AS,
Veturi Y,
Feng Q,
Rosenthal EA,
Lingren T,
Pacheco JA,
Pendergrass SA,
Haessler J,
Giulianini F,
Bradford Y,
Miller JE,
Campbell A,
Lin K,
Millwood IY,
Hindy G,
Rasheed A,
Faul JD,
Zhao W,
Weir DR,
Turman C,
Huang H,
Graff M,
Mahajan A,
Brown MR,
Zhang W,
Yu K,
Schmidt EM,
Pandit A,
Gustafsson S,
Yin X,
Luan J,
Zhao JH,
Matsuda F,
Jang HM,
Yoon K,
Medina-Gomez C,
Pitsillides A,
Hottenga JJ,
Willemsen G,
Wood AR,
Ji Y,
Gao Z,
Haworth S,
Mitchell RE,
Chai JF,
Aadahl M,
Yao J,
Manichaikul A,
Warren HR,
Ramirez J,
Bork-Jensen J,
Kårhus LL,
Goel A,
Sabater-Lleal M,
Noordam R,
Sidore C,
Fiorillo E,
McDaid AF,
Marques-Vidal P,
Wielscher M,
Trompet S,
Sattar N,
Møllehave LT,
Thuesen BH,
Munz M,
Zeng L,
Huang J,
Yang B,
Poveda A,
Kurbasic A,
Lamina C,
Forer L,
Scholz M,
Galesloot TE,
Bradfield JP,
Daw EW,
Zmuda JM,
Mitchell JS,
Fuchsberger C,
Christensen H,
Brody JA,
Feitosa MF,
Wojczynski MK,
Preuss M,
Mangino M,
Christofidou P,
Verweij N,
Benjamins JW,
Engmann J,
Kember RL,
Slieker RC,
Lo KS,
Zilhao NR,
Le P,
Kleber ME,
Delgado GE,
Huo S,
Ikeda DD,
Iha H,
Yang J,
Liu J,
Leonard HL,
Marten J,
Schmidt B,
Arendt M,
Smyth LJ,
Cañadas-Garre M,
Wang C,
Nakatochi M,
Wong A,
Hutri-Kähönen N,
Sim X,
Xia R,
Huerta-Chagoya A,
Fernandez-Lopez JC,
Lyssenko V,
Ahmed M,
Jackson AU,
Yousri NA,
Irvin MR,
Oldmeadow C,
Kim HN,
Ryu S,
Timmers PRHJ,
Arbeeva L,
Dorajoo R,
Lange LA,
Chai X,
Prasad G,
Lorés-Motta L,
Pauper M,
Long J,
Li X,
Theusch E,
Takeuchi F,
Spracklen CN,
Loukola A,
Bollepalli S,
Warner SC,
Wang YX,
Wei WB,
Nutile T,
Ruggiero D,
Sung YJ,
Hung YJ,
Chen S,
Liu F,
Yang J,
Kentistou KA,
Gorski M,
Brumat M,
Meidtner K,
Bielak LF,
Smith JA,
Hebbar P,
Farmaki AE,
Hofer E,
Lin M,
Xue C,
Zhang J,
Concas MP,
Vaccargiu S,
van der Most PJ,
Pitkänen N,
Cade BE,
Lee J,
van der Laan SW,
Chitrala KN,
Weiss S,
Zimmermann ME,
Lee JY,
Choi HS,
Nethander M,
Freitag-Wolf S,
Southam L,
Rayner NW,
Wang CA,
Lin SY,
Wang JS,
Couture C,
Lyytikäinen LP,
Nikus K,
Cuellar-Partida G,
Vestergaard H,
Hildalgo B,
Giannakopoulou O,
Cai Q,
Obura MO,
van Setten J,
Li X,
Schwander K,
Terzikhan N,
Shin JH,
Jackson RD,
Reiner AP,
Martin LW,
Chen Z,
Li L,
Highland HM,
Young KL,
Kawaguchi T,
Thiery J,
Bis JC,
Nadkarni GN,
Launer LJ,
Li H,
Nalls MA,
Raitakari OT,
Ichihara S,
Wild SH,
Nelson CP,
Campbell H,
Jäger S,
Nabika T,
Al-Mulla F,
Niinikoski H,
Braund PS,
Kolcic I,
Kovacs P,
Giardoglou T,
Katsuya T,
Bhatti KF,
de Kleijn D,
de Borst GJ,
Kim EK,
Adams HHH,
Ikram MA,
Zhu X,
Asselbergs FW,
Kraaijeveld AO,
Beulens JWJ,
Shu XO,
Rallidis LS,
Pedersen O,
Hansen T,
Mitchell P,
Hewitt AW,
Kähönen M,
Pérusse L,
Bouchard C,
Tönjes A,
Chen YI,
Pennell CE,
Mori TA,
Lieb W,
Franke A,
Ohlsson C,
Mellström D,
Cho YS,
Lee H,
Yuan JM,
Koh WP,
Rhee SY,
Woo JT,
Heid IM,
Stark KJ,
Völzke H,
Homuth G,
Evans MK,
Zonderman AB,
Polasek O,
Pasterkamp G,
Hoefer IE,
Redline S,
Pahkala K,
Oldehinkel AJ,
Snieder H,
Biino G,
Schmidt R,
Schmidt H,
Chen YE,
Bandinelli S,
Dedoussis G,
Thanaraj TA,
Kardia SLR,
Kato N,
Schulze MB,
Girotto G,
Jung B,
Böger CA,
Joshi PK,
Bennett DA,
De Jager PL,
Lu X,
Mamakou V,
Brown M,
Caulfield MJ,
Munroe PB,
Guo X,
Ciullo M,
Jonas JB,
Samani NJ,
Kaprio J,
Pajukanta P,
Adair LS,
Bechayda SA,
de Silva HJ,
Wickremasinghe AR,
Krauss RM,
Wu JY,
Zheng W,
den Hollander AI,
Bharadwaj D,
Correa A,
Wilson JG,
Lind L,
Heng CK,
Nelson AE,
Golightly YM,
Wilson JF,
Penninx B,
Kim HL,
Attia J,
Scott RJ,
Rao DC,
Arnett DK,
Hunt SC,
Walker M,
Koistinen HA,
Chandak GR,
Yajnik CS,
Mercader JM,
Tusié-Luna T,
Aguilar-Salinas CA,
Villalpando CG,
Orozco L,
Fornage M,
Tai ES,
van Dam RM,
Lehtimäki T,
Chaturvedi N,
Yokota M,
Liu J,
Reilly DF,
McKnight AJ,
Kee F,
Jöckel KH,
McCarthy MI,
Palmer CNA,
Vitart V,
Hayward C,
Simonsick E,
van Duijn CM,
Lu F,
Qu J,
Hishigaki H,
Lin X,
März W,
Parra EJ,
Cruz M,
Gudnason V,
Tardif JC,
Lettre G,
't Hart LM,
Elders PJM,
Damrauer SM,
Kumari M,
Kivimaki M,
van der Harst P,
Spector TD,
Loos RJF,
Province MA,
Psaty BM,
Brandslund I,
Pramstaller PP,
Christensen K,
Ripatti S,
Widén E,
Hakonarson H,
Grant SFA,
Kiemeney LALM,
de Graaf J,
Loeffler M,
Kronenberg F,
Gu D,
Erdmann J,
Schunkert H,
Franks PW,
Linneberg A,
Jukema JW,
Khera AV,
Männikkö M,
Jarvelin MR,
Kutalik Z,
Cucca F,
Mook-Kanamori DO,
van Dijk KW,
Watkins H,
Strachan DP,
Grarup N,
Sever P,
Poulter N,
Rotter JI,
Dantoft TM,
Karpe F,
Neville MJ,
Timpson NJ,
Cheng CY,
Wong TY,
Khor CC,
Sabanayagam C,
Peters A,
Gieger C,
Hattersley AT,
Pedersen NL,
Magnusson PKE,
Boomsma DI,
de Geus EJC,
Cupples LA,
van Meurs JBJ,
Ghanbari M,
Gordon-Larsen P,
Huang W,
Kim YJ,
Tabara Y,
Wareham NJ,
Langenberg C,
Zeggini E,
Kuusisto J,
Laakso M,
Ingelsson E,
Abecasis G,
Chambers JC,
Kooner JS,
de Vries PS,
Morrison AC,
North KE,
Daviglus M,
Kraft P,
Martin NG,
Whitfield JB,
Abbas S,
Saleheen D,
Walters RG,
Holmes MV,
Black C,
Smith BH,
Justice AE,
Baras A,
Buring JE,
Ridker PM,
Chasman DI,
Kooperberg C,
Wei WQ,
Jarvik GP,
Namjou B,
Hayes MG,
Ritchie MD,
Jousilahti P,
Salomaa V,
Hveem K,
Åsvold BO,
Kubo M,
Kamatani Y,
Okada Y,
Murakami Y,
Thorsteinsdottir U,
Stefansson K,
Ho YL,
Lynch JA,
Rader DJ,
Tsao PS,
Chang KM,
Cho K,
O'Donnell CJ,
Gaziano JM,
Wilson P,
Rotimi CN,
Hazelhurst S,
Ramsay M,
Trembath RC,
van Heel DA,
Tamiya G,
Yamamoto M,
Kim BJ,
Mohlke KL,
Frayling TM,
Hirschhorn JN,
Kathiresan S;
VA Million Veteran Program;
Global Lipids Genetics Consortium*,
Boehnke M,
Natarajan P,
Peloso GM,
Brown CD,
Morris AP,
Assimes TL,
Deloukas P,
Sun YV,
Willer CJ</span><br />
<span class="medgenPMjournal">Nature</span>
2021 Dec;600(7890):675-679.
Epub 2021 Dec 9
doi: 10.1038/s41586-021-04064-3.
<span class="bold">PMID: </span><a href="/pubmed/34887591" target="_blank">34887591</a><a href="/pmc/articles/PMC8730582" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29304378">Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Medina-Gomez C,
Kemp JP,
Trajanoska K,
Luan J,
Chesi A,
Ahluwalia TS,
Mook-Kanamori DO,
Ham A,
Hartwig FP,
Evans DS,
Joro R,
Nedeljkovic I,
Zheng HF,
Zhu K,
Atalay M,
Liu CT,
Nethander M,
Broer L,
Porleifsson G,
Mullin BH,
Handelman SK,
Nalls MA,
Jessen LE,
Heppe DHM,
Richards JB,
Wang C,
Chawes B,
Schraut KE,
Amin N,
Wareham N,
Karasik D,
Van der Velde N,
Ikram MA,
Zemel BS,
Zhou Y,
Carlsson CJ,
Liu Y,
McGuigan FE,
Boer CG,
Bønnelykke K,
Ralston SH,
Robbins JA,
Walsh JP,
Zillikens MC,
Langenberg C,
Li-Gao R,
Williams FMK,
Harris TB,
Akesson K,
Jackson RD,
Sigurdsson G,
den Heijer M,
van der Eerden BCJ,
van de Peppel J,
Spector TD,
Pennell C,
Horta BL,
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Ghanbari M,
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<div class="portlet_content ln"><span class="medgenPMauthor">Campbell AW,
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Zhu K,
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Zhou Y,
Carlsson CJ,
Liu Y,
McGuigan FE,
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Jackson RD,
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Felix JF,
Zhao JH,
Wilson SG,
de Mutsert R,
Bisgaard H,
Styrkársdóttir U,
Jaddoe VW,
Orwoll E,
Lakka TA,
Scott R,
Grant SFA,
Lorentzon M,
van Duijn CM,
Wilson JF,
Stefansson K,
Psaty BM,
Kiel DP,
Ohlsson C,
Ntzani E,
van Wijnen AJ,
Forgetta V,
Ghanbari M,
Logan JG,
Williams GR,
Bassett JHD,
Croucher PI,
Evangelou E,
Uitterlinden AG,
Ackert-Bicknell CL,
Tobias JH,
Evans DM,
Rivadeneira F</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/29304378" target="_blank">29304378</a><a href="/pmc/articles/PMC5777980" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/16675885">The search for human osteoporosis genes.</a></div>
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Sheu YT,
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Zhao LJ,
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<span class="bold">PMID: </span><a href="/pubmed/16234971" target="_blank">16234971</a></div>
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VA Million Veteran Program;
Global Lipids Genetics Consortium*,
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<div class="nl"><a target="_blank" href="/pubmed/22504420">Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.</a></div>
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<span class="bold">PMID: </span><a href="/pubmed/22504420" target="_blank">22504420</a><a href="/pmc/articles/PMC3338864" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19427925">Bone mineral density variation in men is influenced by sex-specific and non sex-specific quantitative trait loci.</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bone%20mineral%20density%20variation%20quantitative%20trait%20locus%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (13)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/34887591">The power of genetic diversity in genome-wide association studies of lipids.</a></div>
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<span class="bold">PMID: </span><a href="/pubmed/22692763" target="_blank">22692763</a><a href="/pmc/articles/PMC3447125" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22504420">Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.</a></div>
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Gudnason V,
Hofman A,
Jackson RD,
Jones G,
Jukema JW,
Khaw KT,
Lehtimäki T,
Liu Y,
Lorentzon M,
McCloskey E,
Mitchell BD,
Nandakumar K,
Nicholson GC,
Oostra BA,
Peacock M,
Pols HA,
Prince RL,
Raitakari O,
Reid IR,
Robbins J,
Sambrook PN,
Sham PC,
Shuldiner AR,
Tylavsky FA,
van Duijn CM,
Wareham NJ,
Cupples LA,
Econs MJ,
Evans DM,
Harris TB,
Kung AW,
Psaty BM,
Reeve J,
Spector TD,
Streeten EA,
Zillikens MC,
Thorsteinsdottir U,
Ohlsson C,
Karasik D,
Richards JB,
Brown MA,
Stefansson K,
Uitterlinden AG,
Ralston SH,
Ioannidis JP,
Kiel DP,
Rivadeneira F</span><br />
<span class="medgenPMjournal">Nat Genet</span>
2012 Apr 15;44(5):491-501.
doi: 10.1038/ng.2249.
<span class="bold">PMID: </span><a href="/pubmed/22504420" target="_blank">22504420</a><a href="/pmc/articles/PMC3338864" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19427925">Bone mineral density variation in men is influenced by sex-specific and non sex-specific quantitative trait loci.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Peacock M,
Koller DL,
Lai D,
Hui S,
Foroud T,
Econs MJ</span><br />
<span class="medgenPMjournal">Bone</span>
2009 Sep;45(3):443-8.
Epub 2009 May 8
doi: 10.1016/j.bone.2009.05.002.
<span class="bold">PMID: </span><a href="/pubmed/19427925" target="_blank">19427925</a><a href="/pmc/articles/PMC2725190" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19067020">Quantitative trait locus on chromosome 1q influences bone loss in young Mexican American adults.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shaffer JR,
Kammerer CM,
Bruder JM,
Cole SA,
Dyer TD,
Almasy L,
Maccluer JW,
Blangero J,
Bauer RL,
Mitchell BD</span><br />
<span class="medgenPMjournal">Calcif Tissue Int</span>
2009 Feb;84(2):75-84.
Epub 2008 Dec 9
doi: 10.1007/s00223-008-9197-3.
<span class="bold">PMID: </span><a href="/pubmed/19067020" target="_blank">19067020</a><a href="/pmc/articles/PMC2680710" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bone%20mineral%20density%20variation%20quantitative%20trait%20locus%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (31)</a></div></div>
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