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<meta name="keywords" content="C3150891, chuk, cocoon syndrome, disease or syndrome, fetal encasement syndrome, foetal encasement syndrome, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A rare lethal developmental defect during embryogenesis with characteristics of severe fetal malformations. These malformations include craniofacial dysmorphism (abnormal cyst in the cranial region, hypoplastic eyeballs, two orifices in the nasal region separated by a nasal septum, abnormal orifice replacing the mouth), omphalocele and immotile hypoplastic limbs encased under an abnormal, transparent membrane-like skin. Additional features include absence of adnexal structures of the skin on the outer aspect of the limbs, as well as underdeveloped skeletal muscles and bones. Association with tetralogy of Fallot, horseshoe kidneys, diaphragm and lung lobulation defects is reported." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Cocoon syndrome (Concept Id: C3150891)
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<!--
UID=462241
ConceptID=C3150891
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Cocoon syndrome</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462241</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C3150891</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
<td>FETAL ENCASEMENT SYNDROME</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Cocoon syndrome (1220575002); Fetal encasement syndrome (1220575002)</td></tr>
<tr><td>Modes of inheritance:</td>
<td>
<div class="divPopper rprt" id="moi_141025"><div><strong>Autosomal recessive inheritance</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>141025</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0441748</a></dd><dt><span class="dotprefix"></span></dt><dd>Intellectual Product</dd></dl></div></div></div>
<div class="spaceAbove">Source: Orphanet</div>
<div class="spaceAbove">A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygotes (two copies of the same mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).</div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_141025" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal recessive inheritance</a><span> (Orphanet)</span></div></td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
Gene(s) directly associated with<br />
this condition or phenotype.</div></td>
<td><a target="_blank" title="CHUK - ID: 1147 - NCBI Gene" href="/gene/1147" class="medgenPMinfo">CHUK</a> (10q24.31)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0013334" target="_blank">MONDO:0013334</a></td></tr>
<tr><td>OMIM<span class="superscript">®</span>:</td>
<td><a href="https://omim.org/entry/613630" target="_blank">613630</a></td></tr>
<tr><td>Orphanet:</td>
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&amp;Expert=465824">ORPHA465824</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">A rare lethal developmental defect during embryogenesis with characteristics of severe fetal malformations. These malformations include craniofacial dysmorphism (abnormal cyst in the cranial region, hypoplastic eyeballs, two orifices in the nasal region separated by a nasal septum, abnormal orifice replacing the mouth), omphalocele and immotile hypoplastic limbs encased under an abnormal, transparent membrane-like skin. Additional features include absence of adnexal structures of the skin on the outer aspect of the limbs, as well as underdeveloped skeletal muscles and bones. Association with tetralogy of Fallot, horseshoe kidneys, diaphragm and lung lobulation defects is reported. [from <a title="US Edition of SNOMED CT" href="http://www.nlm.nih.gov/research/umls/Snomed/us_edition.html" class="defSource" target="_blank">SNOMEDCT_US</a>]</div>
</div>
<div class="portlet mgSection" id="ID_102">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
<div class="divPopper rprt" id="clin_65140"><div><strong>Horseshoe kidney</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>65140</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0221353</a></dd><dt><span class="dotprefix"></span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
<div class="spaceAbove">A connection of the right and left kidney by an isthmus of functioning renal parenchyma or fibrous tissue that crosses the midline.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/65140">Feature record</a> | <a href="/medgen?term=%22Horseshoe%20kidney%22%5BClinical%20Features%5D%20OR%2065140%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_1780947"><div><strong>Increased urinary 8-oxo-7,8-dihydroguanosine level</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1780947</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5542183</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">An elevated amount of 8-oxo-7,8-dihydroguanosine in the urine.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1780947">Feature record</a> | <a href="/medgen?term=%22Increased%20urinary%208-oxo-7%2C8-dihydroguanosine%20level%22%5BClinical%20Features%5D%20OR%201780947%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_138016"><div><strong>Lower limb undergrowth</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>138016</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0345371</a></dd><dt><span class="dotprefix"></span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
<div class="spaceAbove">Leg shortening because of underdevelopment of one or more bones of the lower extremity.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/138016">Feature record</a> | <a href="/medgen?term=%22Lower%20limb%20undergrowth%22%5BClinical%20Features%5D%20OR%20138016%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_324789"><div><strong>Upper limb undergrowth</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>324789</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1837406</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">Arm shortening because of underdevelopment of one or more bones of the upper extremity.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/324789">Feature record</a> | <a href="/medgen?term=%22Upper%20limb%20undergrowth%22%5BClinical%20Features%5D%20OR%20324789%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_21498"><div><strong>Tetralogy of Fallot</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>21498</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0039685</a></dd><dt><span class="dotprefix"></span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
<div class="spaceAbove">People with CCHD have one or more specific heart defects. The heart defects classified as CCHD include coarctation of the aorta, double-outlet right ventricle, D-transposition of the great arteries, Ebstein anomaly, hypoplastic left heart syndrome, interrupted aortic arch, pulmonary atresia with intact septum, single ventricle, total anomalous pulmonary venous connection, tetralogy of Fallot, tricuspid atresia, and truncus arteriosus.\n\nEach of the heart defects associated with CCHD affects the flow of blood into, out of, or through the heart. Some of the heart defects involve structures within the heart itself, such as the two lower chambers of the heart (the ventricles) or the valves that control blood flow through the heart. Others affect the structure of the large blood vessels leading into and out of the heart (including the aorta and pulmonary artery). Still others involve a combination of these structural abnormalities.\n\nSome people with treated CCHD have few related health problems later in life. However, long-term effects of CCHD can include delayed development and reduced stamina during exercise. Adults with these heart defects have an increased risk of abnormal heart rhythms, heart failure, sudden cardiac arrest, stroke, and premature death.\n\nAlthough babies with CCHD may appear healthy for the first few hours or days of life, signs and symptoms soon become apparent. These can include an abnormal heart sound during a heartbeat (heart murmur), rapid breathing (tachypnea), low blood pressure (hypotension), low levels of oxygen in the blood (hypoxemia), and a blue or purple tint to the skin caused by a shortage of oxygen (cyanosis). If untreated, CCHD can lead to shock, coma, and death. However, most people with CCHD now survive past infancy due to improvements in early detection, diagnosis, and treatment.\n\nCritical congenital heart disease (CCHD) is a term that refers to a group of serious heart defects that are present from birth. These abnormalities result from problems with the formation of one or more parts of the heart during the early stages of embryonic development. CCHD prevents the heart from pumping blood effectively or reduces the amount of oxygen in the blood. As a result, organs and tissues throughout the body do not receive enough oxygen, which can lead to organ damage and life-threatening complications. Individuals with CCHD usually require surgery soon after birth.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/21498">Feature record</a> | <a href="/medgen?term=%22Tetralogy%20of%20Fallot%22%5BClinical%20Features%5D%20OR%2021498%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_68625"><div><strong>Congenital diaphragmatic hernia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>68625</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0235833</a></dd><dt><span class="dotprefix"></span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
<div class="spaceAbove">The presence of a hernia of the diaphragm present at birth.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/68625">Feature record</a> | <a href="/medgen?term=%22Congenital%20diaphragmatic%20hernia%22%5BClinical%20Features%5D%20OR%2068625%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_162756"><div><strong>Congenital omphalocele</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>162756</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0795690</a></dd><dt><span class="dotprefix"></span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
<div class="spaceAbove">An omphalocele is an abdominal wall defect limited to an open umbilical ring, and is characterized by the herniation of membrane-covered internal organs into the open base of the umbilical cord. Omphalocele is distinguished from gastroschisis (230750), in which the abdominal wall defect is located laterally to a normally closed umbilical ring with herniation of organs that are uncovered by membranes (summary by Bugge, 2010). On the basis of clinical manifestations, epidemiologic characteristics, and the presence of additional malformations, Yang et al. (1992) concluded that omphalocele and gastroschisis are casually and pathogenetically distinct abdominal wall defects.&#13; Omphalocele can be a feature of genetic disorders, such as Beckwith-Wiedemann syndrome (130650) and the Shprintzen-Goldberg syndrome (182210).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/162756">Feature record</a> | <a href="/medgen?term=%22Congenital%20omphalocele%22%5BClinical%20Features%5D%20OR%20162756%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_756785"><div><strong>Bilateral trilobed lung</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>756785</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3164377</a></dd><dt><span class="dotprefix"></span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
<div class="spaceAbove">Both lungs have three lobes. Normally, the left lung has two lobes, whereas the right lung has three lobes.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/756785">Feature record</a> | <a href="/medgen?term=%22Bilateral%20trilobed%20lung%22%5BClinical%20Features%5D%20OR%20756785%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_140848"><div><strong>Thin skin</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>140848</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0423757</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">Reduction in thickness of the skin, generally associated with a loss of suppleness and elasticity of the skin.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/140848">Feature record</a> | <a href="/medgen?term=%22Thin%20skin%22%5BClinical%20Features%5D%20OR%20140848%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_68618"><div><strong>Decreased fetal movement</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>68618</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0235659</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">An abnormal reduction in quantity or strength of fetal movements.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/68618">Feature record</a> | <a href="/medgen?term=%22Decreased%20fetal%20movement%22%5BClinical%20Features%5D%20OR%2068618%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(&quot;.TreeLite&quot;,&quot;#ID_102&quot;).TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(&quot;.TreeLite&quot;,&quot;#ID_102&quot;).TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of limbs</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_138016" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Lower limb undergrowth</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_324789" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Upper limb undergrowth</a></span></li></ul></li><li><span class="TLline">Abnormality of prenatal development or birth</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_68618" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Decreased fetal movement</a></span></li></ul></li><li><span class="TLline">Abnormality of the cardiovascular system</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_21498" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Tetralogy of Fallot</a></span></li></ul></li><li><span class="TLline">Abnormality of the genitourinary system</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_65140" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Horseshoe kidney</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1780947" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Increased urinary 8-oxo-7,8-dihydroguanosine level</a></span></li></ul></li><li><span class="TLline">Abnormality of the integument</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_140848" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Thin skin</a></span></li></ul></li><li><span class="TLline">Abnormality of the musculoskeletal system</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_68625" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Congenital diaphragmatic hernia</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_162756" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Congenital omphalocele</a></span></li></ul></li><li><span class="TLline">Abnormality of the respiratory system</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_756785" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bilateral trilobed lung</a></span></li></ul></li></ul></div></div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3150891[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=462241">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=462241" target="_blank" href="/omim/600664">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=462241" ref="ncbi_uid=462241">V</a></span></span><span class="TLline">Cocoon syndrome</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/1842568" ref="tree=MeSH" title="MedGen record for Syndrome with limb malformations as a major feature">Syndrome with limb malformations as a major feature</a></span><ul><li><span class="matched_ds">Cocoon syndrome</span></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/25593498">Accurate definition and management of idiopathic sclerosing encapsulating peritonitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Akbulut S</span><br />
<span class="medgenPMjournal">World J Gastroenterol</span>
2015 Jan 14;21(2):675-87.
doi: 10.3748/wjg.v21.i2.675.
<span class="bold">PMID: </span><a href="/pubmed/25593498" target="_blank">25593498</a><a href="/pmc/articles/PMC4292304" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22cocoon%20syndrome%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/36872044">Sclerosing Encapsulating Peritonitis: A Rare Cause of Bowel Obstruction.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">McCrory MA,
Heard MA,
Wright JG,
Roche KF</span><br />
<span class="medgenPMjournal">Am Surg</span>
2023 Aug;89(8):3496-3498.
Epub 2023 Mar 5
doi: 10.1177/00031348231160821.
<span class="bold">PMID: </span><a href="/pubmed/36872044" target="_blank">36872044</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33054747">Primary abdominal cocoon with cryptorchidism: a case report.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Song WJ,
Liu XY,
Saad GAA,
Khan A,
Yang KY,
Zhang Y,
Liu JY,
He LY</span><br />
<span class="medgenPMjournal">BMC Gastroenterol</span>
2020 Oct 14;20(1):334.
doi: 10.1186/s12876-020-01466-x.
<span class="bold">PMID: </span><a href="/pubmed/33054747" target="_blank">33054747</a><a href="/pmc/articles/PMC7557050" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31701503">Abdominal cocoon syndrome: A rare cause of acute abdomen syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Çolak Ş,
Bektaş H</span><br />
<span class="medgenPMjournal">Ulus Travma Acil Cerrahi Derg</span>
2019 Nov;25(6):575-579.
doi: 10.14744/tjtes.2019.48380.
<span class="bold">PMID: </span><a href="/pubmed/31701503" target="_blank">31701503</a></div>
<div class="nl"><a target="_blank" href="/pubmed/16630775">Abdominal cocoon syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Matone J,
Herbella F,
Del Grande JC</span><br />
<span class="medgenPMjournal">Clin Gastroenterol Hepatol</span>
2006 May;4(5):xxxi.
doi: 10.1016/j.cgh.2005.12.005.
<span class="bold">PMID: </span><a href="/pubmed/16630775" target="_blank">16630775</a></div>
<div class="nl"><a target="_blank" href="/pubmed/3992618">Backgrounds of higher suicide rates among "name university" students: a retrospective study of the past 25 years.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ishii K</span><br />
<span class="medgenPMjournal">Suicide Life Threat Behav</span>
1985 Spring;15(1):56-68.
doi: 10.1111/j.1943-278x.1985.tb00789.x.
<span class="bold">PMID: </span><a href="/pubmed/3992618" target="_blank">3992618</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cocoon%20syndrome%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/36872044">Sclerosing Encapsulating Peritonitis: A Rare Cause of Bowel Obstruction.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">McCrory MA,
Heard MA,
Wright JG,
Roche KF</span><br />
<span class="medgenPMjournal">Am Surg</span>
2023 Aug;89(8):3496-3498.
Epub 2023 Mar 5
doi: 10.1177/00031348231160821.
<span class="bold">PMID: </span><a href="/pubmed/36872044" target="_blank">36872044</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31455947">Abdominal Cocoon Syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pokharel P,
Bista Y,
Desar R,
Benjankar RB,
Sharma P</span><br />
<span class="medgenPMjournal">J Nepal Health Res Counc</span>
2019 Aug 4;17(2):264-266.
doi: 10.33314/jnhrc.v0i0.1934.
<span class="bold">PMID: </span><a href="/pubmed/31455947" target="_blank">31455947</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31431239">Abdominal Cocoon Syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Karl AP,
Leebmann H,
Zorger N</span><br />
<span class="medgenPMjournal">Dtsch Arztebl Int</span>
2019 Jul 8;116(27-28):486.
doi: 10.3238/arztebl.2019.0486b.
<span class="bold">PMID: </span><a href="/pubmed/31431239" target="_blank">31431239</a><a href="/pmc/articles/PMC6718890" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25835123">Idiopathic abdominal cocoon syndrome: Preoperative diagnosis with computed tomography.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Karan A,
Özdemir M,
Bostancı MT,
Bostancı EB</span><br />
<span class="medgenPMjournal">Turk J Gastroenterol</span>
2015 Mar;26(2):193-4.
doi: 10.5152/tjg.2015.7312.
<span class="bold">PMID: </span><a href="/pubmed/25835123" target="_blank">25835123</a></div>
<div class="nl"><a target="_blank" href="/pubmed/16630775">Abdominal cocoon syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Matone J,
Herbella F,
Del Grande JC</span><br />
<span class="medgenPMjournal">Clin Gastroenterol Hepatol</span>
2006 May;4(5):xxxi.
doi: 10.1016/j.cgh.2005.12.005.
<span class="bold">PMID: </span><a href="/pubmed/16630775" target="_blank">16630775</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cocoon%20syndrome%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (29)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/38862118">Abdominal cocoon syndrome (sclerosing encapsulated peritonitis) causing small bowel occlusion in a patient with gastric bypass.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lucero-Serrano F,
Herrera-González A,
Valenzuela-Salazar C,
Sánchez-Castro ÓE,
Zerrweck C</span><br />
<span class="medgenPMjournal">Cir Cir</span>
2024;92(3):395-398.
doi: 10.24875/CIRU.22000335.
<span class="bold">PMID: </span><a href="/pubmed/38862118" target="_blank">38862118</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36482551">A case report of encapsulating peritoneal sclerosis followed by cesarean section: Clinical diagnosis and treatment experience.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Liang JL,
Chen ZQ,
Yi Z,
Kun Ming W</span><br />
<span class="medgenPMjournal">Medicine (Baltimore)</span>
2022 Dec 2;101(48):e32122.
doi: 10.1097/MD.0000000000032122.
<span class="bold">PMID: </span><a href="/pubmed/36482551" target="_blank">36482551</a><a href="/pmc/articles/PMC9726339" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27239122">Idiopathic abdominal cocoon syndrome with unilateral abdominal cryptorchidism and greater omentum hypoplasia in a young case of small bowel obstruction.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fei X,
Yang HR,
Yu PF,
Sheng HB,
Gu GL</span><br />
<span class="medgenPMjournal">World J Gastroenterol</span>
2016 May 28;22(20):4958-62.
doi: 10.3748/wjg.v22.i20.4958.
<span class="bold">PMID: </span><a href="/pubmed/27239122" target="_blank">27239122</a><a href="/pmc/articles/PMC4873888" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26607132">Abdominal cocoon syndrome caused by Mycobacterium bovis from consumption of unpasteurised cow's milk.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Anantha RV,
Salvadori MI,
Hussein MH,
Merritt N</span><br />
<span class="medgenPMjournal">Lancet Infect Dis</span>
2015 Dec;15(12):1498.
Epub 2015 Nov 16
doi: 10.1016/S1473-3099(15)00438-7.
<span class="bold">PMID: </span><a href="/pubmed/26607132" target="_blank">26607132</a></div>
<div class="nl"><a target="_blank" href="/pubmed/6710346">Small bowel obstruction caused by the abdominal cocoon syndrome: possible association with the LeVeen shunt.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cambria RP,
Shamberger RC</span><br />
<span class="medgenPMjournal">Surgery</span>
1984 Apr;95(4):501-3.
<span class="bold">PMID: </span><a href="/pubmed/6710346" target="_blank">6710346</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cocoon%20syndrome%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/36482551">A case report of encapsulating peritoneal sclerosis followed by cesarean section: Clinical diagnosis and treatment experience.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Liang JL,
Chen ZQ,
Yi Z,
Kun Ming W</span><br />
<span class="medgenPMjournal">Medicine (Baltimore)</span>
2022 Dec 2;101(48):e32122.
doi: 10.1097/MD.0000000000032122.
<span class="bold">PMID: </span><a href="/pubmed/36482551" target="_blank">36482551</a><a href="/pmc/articles/PMC9726339" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33054747">Primary abdominal cocoon with cryptorchidism: a case report.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Song WJ,
Liu XY,
Saad GAA,
Khan A,
Yang KY,
Zhang Y,
Liu JY,
He LY</span><br />
<span class="medgenPMjournal">BMC Gastroenterol</span>
2020 Oct 14;20(1):334.
doi: 10.1186/s12876-020-01466-x.
<span class="bold">PMID: </span><a href="/pubmed/33054747" target="_blank">33054747</a><a href="/pmc/articles/PMC7557050" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25593498">Accurate definition and management of idiopathic sclerosing encapsulating peritonitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Akbulut S</span><br />
<span class="medgenPMjournal">World J Gastroenterol</span>
2015 Jan 14;21(2):675-87.
doi: 10.3748/wjg.v21.i2.675.
<span class="bold">PMID: </span><a href="/pubmed/25593498" target="_blank">25593498</a><a href="/pmc/articles/PMC4292304" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20172277">Comprehensive surgical intestinal rescue and transplantation program in adult patients: Bologna experience.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zanfi C,
Lauro A,
Cescon M,
Dazzi A,
Ercolani G,
Grazi GL,
Zanello M,
Vivarelli M,
Del Gaudio M,
Ravaioli M,
Cucchetti A,
Vetrone G,
Tuci F,
Di Gioia P,
Lazzarotto T,
D'Errico A,
Bagni A,
Faenza S,
Siniscalchi A,
Pironi L,
Pinna AD</span><br />
<span class="medgenPMjournal">Transplant Proc</span>
2010 Jan-Feb;42(1):39-41.
doi: 10.1016/j.transproceed.2009.12.020.
<span class="bold">PMID: </span><a href="/pubmed/20172277" target="_blank">20172277</a></div>
<div class="nl"><a target="_blank" href="/pubmed/16630775">Abdominal cocoon syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Matone J,
Herbella F,
Del Grande JC</span><br />
<span class="medgenPMjournal">Clin Gastroenterol Hepatol</span>
2006 May;4(5):xxxi.
doi: 10.1016/j.cgh.2005.12.005.
<span class="bold">PMID: </span><a href="/pubmed/16630775" target="_blank">16630775</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cocoon%20syndrome%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/36459388">A forensic case of abdominal cocoon syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tambuzzi S,
Gentile G,
Boracchi M,
Zoja R,
Gentilomo A</span><br />
<span class="medgenPMjournal">Forensic Sci Med Pathol</span>
2023 Jun;19(2):273-279.
Epub 2022 Dec 2
doi: 10.1007/s12024-022-00562-6.
<span class="bold">PMID: </span><a href="/pubmed/36459388" target="_blank">36459388</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31701503">Abdominal cocoon syndrome: A rare cause of acute abdomen syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Çolak Ş,
Bektaş H</span><br />
<span class="medgenPMjournal">Ulus Travma Acil Cerrahi Derg</span>
2019 Nov;25(6):575-579.
doi: 10.14744/tjtes.2019.48380.
<span class="bold">PMID: </span><a href="/pubmed/31701503" target="_blank">31701503</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28803895">Periderm: Life-cycle and function during orofacial and epidermal development.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hammond NL,
Dixon J,
Dixon MJ</span><br />
<span class="medgenPMjournal">Semin Cell Dev Biol</span>
2019 Jul;91:75-83.
Epub 2017 Aug 10
doi: 10.1016/j.semcdb.2017.08.021.
<span class="bold">PMID: </span><a href="/pubmed/28803895" target="_blank">28803895</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27964725">The enigma of primary and secondary encapsulating peritoneal sclerosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Allam H,
Al Yahri O,
Mathew S,
Darweesh A,
Suliman AN,
Abdelaziem S,
Khairat M,
Toro A,
Di Carlo I</span><br />
<span class="medgenPMjournal">BMC Surg</span>
2016 Dec 13;16(1):81.
doi: 10.1186/s12893-016-0198-2.
<span class="bold">PMID: </span><a href="/pubmed/27964725" target="_blank">27964725</a><a href="/pmc/articles/PMC5153754" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25593498">Accurate definition and management of idiopathic sclerosing encapsulating peritonitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Akbulut S</span><br />
<span class="medgenPMjournal">World J Gastroenterol</span>
2015 Jan 14;21(2):675-87.
doi: 10.3748/wjg.v21.i2.675.
<span class="bold">PMID: </span><a href="/pubmed/25593498" target="_blank">25593498</a><a href="/pmc/articles/PMC4292304" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cocoon%20syndrome%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (11)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/35801789">Abdominal cocoon syndrome: Rare cause of intestinal obstruction-Case report and systematic review of literature.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chorti A,
Panidis S,
Konstantinidis D,
Cheva A,
Papavramidis T,
Michalopoulos A,
Paramythiotis D</span><br />
<span class="medgenPMjournal">Medicine (Baltimore)</span>
2022 Jul 8;101(27):e29837.
doi: 10.1097/MD.0000000000029837.
<span class="bold">PMID: </span><a href="/pubmed/35801789" target="_blank">35801789</a><a href="/pmc/articles/PMC9259168" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cocoon%20syndrome%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C3150891%5bDISCUI%5d&amp;filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (5)</a></li>
<li><a href="/gtr/tests?term=C3150891%5bDISCUI%5d&amp;filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (7)</a></li>
<li><a href="/gtr/tests?term=C3150891%5bDISCUI%5d&amp;filter=method%3A2%5F19" target="_blank">Targeted variant analysis (1)</a></li>
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C3150891%5bDISCUI%5d" target="_blank">See all (8)</a></total></li>
</ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&amp;start=1&amp;limit=10&amp;sort=score%20desc&amp;field=number&amp;search=613630" target="_blank">OMIM</a></li><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=465824" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Cocoon%20syndrome" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22cocoon%20syndrome%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&amp;start=1&amp;limit=10&amp;sort=score%20desc&amp;field=number&amp;search=600664" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=1147[geneid]" target="_blank">View CHUK variations in ClinVar</a></li><li><a href="/nuccore/315360647" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=613630" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Cocoon+syndrome/7992" target="_blank">Genetic Alliance</a></li><li><a href="https://www.malacards.org/card/fetal_encasement_syndrome" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&amp;query=Cocoon%20syndrome" target="_blank">MedlinePlus</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/17823/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
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<a href="/pubmed/clinical?term=Cocoon%20syndrome" ref="ncbi_uid=&amp;discoId=gtr_reviews&amp;linkpos=1&amp;linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
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<a href="/pubmed?term=Cocoon%20syndrome%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&amp;discoId=gtr_reviews&amp;linkpos=2&amp;linkpostotal=2" target="_blank">Reviews in PubMed</a>
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<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=462241" ref="log$=recordlinks">ClinVar</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
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<a class="brieflinkpopperctrl" href="/gene?LinkName=medgen_gene_diseases&amp;from_uid=462241" ref="log$=recordlinks">Gene</a>
<div class="brieflinkpop offscreen_noflow">Related information in NCBI Gene</div>
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C3150891[DISCUI]" ref="log$=recordlinks">GTR</a>
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C3150891[DISCUI]&amp;test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
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<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim&amp;from_uid=462241" ref="log$=recordlinks">OMIM</a>
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<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim_gene&amp;from_uid=462241" ref="log$=recordlinks">OMIM(Genes)</a>
<div class="brieflinkpop offscreen_noflow">OMIM records containing genes associated with phenotypes registered in MedGen</div>
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<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&amp;from_uid=462241" ref="log$=recordlinks">PMC Articles</a>
<div class="brieflinkpop offscreen_noflow">Related information in PubMed Central Links</div>
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<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&amp;from_uid=462241" ref="log$=recordlinks">PubMed</a>
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<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_omim&amp;from_uid=462241" ref="log$=recordlinks">PubMed (OMIM)</a>
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<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67cd1cb2a68b6b5afc799931">Cocoon syndrome</a>
<div class="ralinkpop offscreen_noflow">Cocoon syndrome<div class="brieflinkpopdesc"></div></div>
<div class="tertiary">MedGen</div>
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<li class="ra_qry two_line">
<a class="htb" ref="log$=activity&amp;linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67cd1cb1f4a390645e4c661d">C3150891[conceptid] <span class="number">(1)</span></a>
<div class="tertiary">MedGen</div>
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<li class="ra_qry two_line">
<a class="htb" ref="log$=activity&amp;linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67cd1cb0f4a390645e4c6149">C0751038[trait identifier] AND "OMIM"[submitter] <span class="number">(12)</span></a>
<div class="tertiary">ClinVar</div>
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<li class="ra_qry two_line">
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