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<meta name="keywords" content="C1510489, caa, familial, cerebral amyloid angiopathy, cerebral amyloid angiopathy, familial, cerebral amyloid angiopathy, genetic, cerebral amyloid angiopathy, hereditary, cerebral hemorrhage, hereditary, with amyloidosis, disease or syndrome, dutch hereditary cerebral amyloid angiopathy, hchwa, hchwa - hereditary cerebral hemorrhage with amyloidosis, hereditary cerebral amyloid angiopathy, hereditary cerebral haemorrhage with amyloidosis - dutch type, hereditary cerebral hemorrhage with amyloidosis, hereditary cerebral hemorrhage with amyloidosis - dutch type, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Describes a group of rare familial central nervous system disorders characterized by amyloid deposition in the cerebral blood vessels leading to hemorrhagic and non-hemorrhagic strokes, focal neurological deficits, and progressive cognitive decline eventually leading to dementia. Clinical features depend on the disease type. Most forms of HCHWA (Dutch, Arctic, Piedmont, Iowa, Flemish and Italian) are due to a point-mutation in the APP gene on chromosome 21q21.2, which encodes the beta-amyloid precursor protein. This mutation causes increased accumulation of amyloid-beta protein in the walls of cerebral arteries and capillaries. Only one form of HCHWA, Icelandic type, is due to a mutation in the CST3 gene on chromosome 20p11.2, encoding the precursor protein cystatin C." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Hereditary cerebral hemorrhage with amyloidosis (Concept Id: C1510489)
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<!--
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UID=267610
|
||
ConceptID=C1510489
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Hereditary cerebral hemorrhage with amyloidosis<span class="h1sub">(HCHWA)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>267610</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C1510489</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Cerebral Amyloid Angiopathy, Hereditary</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Hereditary cerebral hemorrhage with amyloidosis (724357007); HCHWA - hereditary cerebral hemorrhage with amyloidosis (724357007)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_141047"><div><strong>Autosomal dominant inheritance</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>141047</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0443147</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Intellectual Product</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.</div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_141047" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant inheritance</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0005620" target="_blank">MONDO:0005620</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/105150" target="_blank">105150</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=85458">ORPHA85458</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_100">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Describes a group of rare familial central nervous system disorders characterized by amyloid deposition in the cerebral blood vessels leading to hemorrhagic and non-hemorrhagic strokes, focal neurological deficits, and progressive cognitive decline eventually leading to dementia. Clinical features depend on the disease type. Most forms of HCHWA (Dutch, Arctic, Piedmont, Iowa, Flemish and Italian) are due to a point-mutation in the APP gene on chromosome 21q21.2, which encodes the beta-amyloid precursor protein. This mutation causes increased accumulation of amyloid-beta protein in the walls of cerebral arteries and capillaries. Only one form of HCHWA, Icelandic type, is due to a mutation in the CST3 gene on chromosome 20p11.2, encoding the precursor protein cystatin C. [from <a title="US Edition of SNOMED CT" href="http://www.nlm.nih.gov/research/umls/Snomed/us_edition.html" class="defSource" target="_blank">SNOMEDCT_US</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=267610" target="_blank" href="/omim/105150">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=267610" ref="ncbi_uid=267610">V</a></span></span><span class="TLline">Hereditary cerebral hemorrhage with amyloidosis</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/867398" ref="tree=MeSH" title="MedGen record for Abnormality of metabolism/homeostasis">Abnormality of metabolism/homeostasis</a></span><ul><li><span class="TLline"><a href="/medgen/272" ref="tree=MeSH" title="MedGen record for Amyloidosis">Amyloidosis</a></span><ul><li><span class="matched_ds">Hereditary cerebral hemorrhage with amyloidosis</span><ul><li><span class="TLline"><a href="/medgen/414032" ref="tree=MeSH" title="MedGen record for ABeta amyloidosis, Arctic type">ABeta amyloidosis, Arctic type</a></span></li><li><span class="TLline"><a href="/medgen/419468" ref="tree=MeSH" title="MedGen record for ABeta amyloidosis, dutch type">ABeta amyloidosis, dutch type</a></span></li><li><span class="TLline"><a href="/medgen/854855" ref="tree=MeSH" title="MedGen record for ABeta amyloidosis, Iowa type">ABeta amyloidosis, Iowa type</a></span></li><li><span class="TLline"><a href="/medgen/854854" ref="tree=MeSH" title="MedGen record for ABeta amyloidosis, Italian type">ABeta amyloidosis, Italian type</a></span></li><li><span class="TLline"><a href="/medgen/854853" ref="tree=MeSH" title="MedGen record for ABetaA21G amyloidosis">ABetaA21G amyloidosis</a></span></li><li><span class="TLline"><a href="/medgen/1842835" ref="tree=MeSH" title="MedGen record for ABetaL34V amyloidosis">ABetaL34V amyloidosis</a></span></li><li><span class="TLline"><a href="/medgen/279656" ref="tree=MeSH" title="MedGen record for Hereditary cerebral amyloid angiopathy, Icelandic type">Hereditary cerebral amyloid angiopathy, Icelandic type</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/10818507">Amyloid-beta-induced degeneration of human brain pericytes is dependent on the apolipoprotein E genotype.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Verbeek MM,
|
||
Van Nostrand WE,
|
||
Otte-Höller I,
|
||
Wesseling P,
|
||
De Waal RM</span><br />
|
||
<span class="medgenPMjournal">Ann N Y Acad Sci</span>
|
||
2000 Apr;903:187-99.
|
||
doi: 10.1111/j.1749-6632.2000.tb06368.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10818507" target="_blank">10818507</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9450860">Distress in individuals facing predictive DNA testing for autosomal dominant late-onset disorders: comparing questionnaire results with in-depth interviews. Rotterdam/Leiden Genetics Workgroup.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">DudokdeWit AC,
|
||
Tibben A,
|
||
Duivenvoorden HJ,
|
||
Niermeijer MF,
|
||
Passchier J,
|
||
Trijsburg RW</span><br />
|
||
<span class="medgenPMjournal">Am J Med Genet</span>
|
||
1998 Jan 6;75(1):62-74.
|
||
doi: 10.1002/(sici)1096-8628(19980106)75:1<62::aid-ajmg14>3.0.co;2-q.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9450860" target="_blank">9450860</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9153536">Dutch hereditary cerebral amyloid angiopathy: structural lesions and apolipoprotein E genotype.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bornebroek M,
|
||
Haan J,
|
||
Van Duinen SG,
|
||
Maat-Schieman ML,
|
||
Van Buchem MA,
|
||
Bakker E,
|
||
Van Broeckhoven C,
|
||
Roos RA</span><br />
|
||
<span class="medgenPMjournal">Ann Neurol</span>
|
||
1997 May;41(5):695-8.
|
||
doi: 10.1002/ana.410410523.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9153536" target="_blank">9153536</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22hereditary%20cerebral%20hemorrhage%20with%20amyloidosis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (3)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27590282">Recurrent hemorrhage risk and mortality in hereditary and sporadic cerebral amyloid angiopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van Etten ES,
|
||
Gurol ME,
|
||
van der Grond J,
|
||
Haan J,
|
||
Viswanathan A,
|
||
Schwab KM,
|
||
Ayres AM,
|
||
Algra A,
|
||
Rosand J,
|
||
van Buchem MA,
|
||
Terwindt GM,
|
||
Greenberg SM,
|
||
Wermer MJ</span><br />
|
||
<span class="medgenPMjournal">Neurology</span>
|
||
2016 Oct 4;87(14):1482-1487.
|
||
Epub 2016 Sep 2
|
||
doi: 10.1212/WNL.0000000000003181.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27590282" target="_blank">27590282</a><a href="/pmc/articles/PMC5075977" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10524288">Hereditary cerebral hemorrhage with amyloidosis--Dutch type (HCHWA-D): a review of the variety in phenotypic expression.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bornebroek M,
|
||
Haan J,
|
||
Roos RA</span><br />
|
||
<span class="medgenPMjournal">Amyloid</span>
|
||
1999 Sep;6(3):215-24.
|
||
doi: 10.3109/13506129909007331.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10524288" target="_blank">10524288</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8737926">Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D): I--A review of clinical, radiologic and genetic aspects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bornebroek M,
|
||
Haan J,
|
||
Maat-Schieman ML,
|
||
Van Duinen SG,
|
||
Roos RA</span><br />
|
||
<span class="medgenPMjournal">Brain Pathol</span>
|
||
1996 Apr;6(2):111-4.
|
||
doi: 10.1111/j.1750-3639.1996.tb00793.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8737926" target="_blank">8737926</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1679289">DNA diagnosis for hereditary cerebral hemorrhage with amyloidosis (Dutch type).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bakker E,
|
||
van Broeckhoven C,
|
||
Haan J,
|
||
Voorhoeve E,
|
||
van Hul W,
|
||
Levy E,
|
||
Lieberburg I,
|
||
Carman MD,
|
||
van Ommen GJ,
|
||
Frangione B</span><br />
|
||
<span class="medgenPMjournal">Am J Hum Genet</span>
|
||
1991 Sep;49(3):518-21.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1679289" target="_blank">1679289</a><a href="/pmc/articles/PMC1683137" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2555088">Hereditary cerebral hemorrhage with amyloidosis--Dutch type. Research-Group Hereditary Cerebral Amyloid-Angiopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Haan J,
|
||
Roos RA,
|
||
Briët PE,
|
||
Herpers MJ,
|
||
Luyendijk W,
|
||
Bots GT</span><br />
|
||
<span class="medgenPMjournal">Clin Neurol Neurosurg</span>
|
||
1989;91(4):285-90.
|
||
doi: 10.1016/0303-8467(89)90003-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2555088" target="_blank">2555088</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hereditary%20cerebral%20hemorrhage%20with%20amyloidosis%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (28)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/30012821">Perivascular Spaces Volume in Sporadic and Hereditary (Dutch-Type) Cerebral Amyloid Angiopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Martinez-Ramirez S,
|
||
van Rooden S,
|
||
Charidimou A,
|
||
van Opstal AM,
|
||
Wermer M,
|
||
Gurol ME,
|
||
Terwindt G,
|
||
van der Grond J,
|
||
Greenberg SM,
|
||
van Buchem M,
|
||
Viswanathan A</span><br />
|
||
<span class="medgenPMjournal">Stroke</span>
|
||
2018 Aug;49(8):1913-1919.
|
||
doi: 10.1161/STROKEAHA.118.021137.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30012821" target="_blank">30012821</a><a href="/pmc/articles/PMC6202219" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28254515">Hereditary cerebral small vessel disease and stroke.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Søndergaard CB,
|
||
Nielsen JE,
|
||
Hansen CK,
|
||
Christensen H</span><br />
|
||
<span class="medgenPMjournal">Clin Neurol Neurosurg</span>
|
||
2017 Apr;155:45-57.
|
||
Epub 2017 Feb 22
|
||
doi: 10.1016/j.clineuro.2017.02.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28254515" target="_blank">28254515</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27590282">Recurrent hemorrhage risk and mortality in hereditary and sporadic cerebral amyloid angiopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van Etten ES,
|
||
Gurol ME,
|
||
van der Grond J,
|
||
Haan J,
|
||
Viswanathan A,
|
||
Schwab KM,
|
||
Ayres AM,
|
||
Algra A,
|
||
Rosand J,
|
||
van Buchem MA,
|
||
Terwindt GM,
|
||
Greenberg SM,
|
||
Wermer MJ</span><br />
|
||
<span class="medgenPMjournal">Neurology</span>
|
||
2016 Oct 4;87(14):1482-1487.
|
||
Epub 2016 Sep 2
|
||
doi: 10.1212/WNL.0000000000003181.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27590282" target="_blank">27590282</a><a href="/pmc/articles/PMC5075977" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16479442">Single-gene stroke disorders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Majersik JJ,
|
||
Skalabrin EJ</span><br />
|
||
<span class="medgenPMjournal">Semin Neurol</span>
|
||
2006 Feb;26(1):33-48.
|
||
doi: 10.1055/s-2006-933307.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16479442" target="_blank">16479442</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8737926">Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D): I--A review of clinical, radiologic and genetic aspects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bornebroek M,
|
||
Haan J,
|
||
Maat-Schieman ML,
|
||
Van Duinen SG,
|
||
Roos RA</span><br />
|
||
<span class="medgenPMjournal">Brain Pathol</span>
|
||
1996 Apr;6(2):111-4.
|
||
doi: 10.1111/j.1750-3639.1996.tb00793.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8737926" target="_blank">8737926</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hereditary%20cerebral%20hemorrhage%20with%20amyloidosis%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (28)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31359452">Early Aβ reduction prevents progression of cerebral amyloid angiopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schelle J,
|
||
Wegenast-Braun BM,
|
||
Fritschi SK,
|
||
Kaeser SA,
|
||
Jährling N,
|
||
Eicke D,
|
||
Skodras A,
|
||
Beschorner N,
|
||
Obermueller U,
|
||
Häsler LM,
|
||
Wolfer DP,
|
||
Mueggler T,
|
||
Shimshek DR,
|
||
Neumann U,
|
||
Dodt HU,
|
||
Staufenbiel M,
|
||
Jucker M</span><br />
|
||
<span class="medgenPMjournal">Ann Neurol</span>
|
||
2019 Oct;86(4):561-571.
|
||
Epub 2019 Aug 19
|
||
doi: 10.1002/ana.25562.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31359452" target="_blank">31359452</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19189048">Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Viana RJ,
|
||
Nunes AF,
|
||
Castro RE,
|
||
Ramalho RM,
|
||
Meyerson J,
|
||
Fossati S,
|
||
Ghiso J,
|
||
Rostagno A,
|
||
Rodrigues CM</span><br />
|
||
<span class="medgenPMjournal">Cell Mol Life Sci</span>
|
||
2009 Mar;66(6):1094-104.
|
||
doi: 10.1007/s00018-009-8746-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19189048" target="_blank">19189048</a><a href="/pmc/articles/PMC2760857" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10861793">Toxicity of various amyloid beta peptide species in cultured human blood-brain barrier endothelial cells: increased toxicity of dutch-type mutant.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eisenhauer PB,
|
||
Johnson RJ,
|
||
Wells JM,
|
||
Davies TA,
|
||
Fine RE</span><br />
|
||
<span class="medgenPMjournal">J Neurosci Res</span>
|
||
2000 Jun 15;60(6):804-10.
|
||
doi: 10.1002/1097-4547(20000615)60:6<804::AID-JNR13>3.0.CO;2-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10861793" target="_blank">10861793</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10850731">Neuroinflammation and Alzheimer disease: clinical and therapeutic implications.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eikelenboom P,
|
||
Rozemuller AJ,
|
||
Hoozemans JJ,
|
||
Veerhuis R,
|
||
van Gool WA</span><br />
|
||
<span class="medgenPMjournal">Alzheimer Dis Assoc Disord</span>
|
||
2000;14 Suppl 1:S54-61.
|
||
doi: 10.1097/00002093-200000001-00009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10850731" target="_blank">10850731</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1679289">DNA diagnosis for hereditary cerebral hemorrhage with amyloidosis (Dutch type).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bakker E,
|
||
van Broeckhoven C,
|
||
Haan J,
|
||
Voorhoeve E,
|
||
van Hul W,
|
||
Levy E,
|
||
Lieberburg I,
|
||
Carman MD,
|
||
van Ommen GJ,
|
||
Frangione B</span><br />
|
||
<span class="medgenPMjournal">Am J Hum Genet</span>
|
||
1991 Sep;49(3):518-21.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1679289" target="_blank">1679289</a><a href="/pmc/articles/PMC1683137" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hereditary%20cerebral%20hemorrhage%20with%20amyloidosis%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27590282">Recurrent hemorrhage risk and mortality in hereditary and sporadic cerebral amyloid angiopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van Etten ES,
|
||
Gurol ME,
|
||
van der Grond J,
|
||
Haan J,
|
||
Viswanathan A,
|
||
Schwab KM,
|
||
Ayres AM,
|
||
Algra A,
|
||
Rosand J,
|
||
van Buchem MA,
|
||
Terwindt GM,
|
||
Greenberg SM,
|
||
Wermer MJ</span><br />
|
||
<span class="medgenPMjournal">Neurology</span>
|
||
2016 Oct 4;87(14):1482-1487.
|
||
Epub 2016 Sep 2
|
||
doi: 10.1212/WNL.0000000000003181.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27590282" target="_blank">27590282</a><a href="/pmc/articles/PMC5075977" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25641254">Do Attachment Style and Emotion Regulation Strategies Indicate Distress in Predictive Testing?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van der Meer LB,
|
||
van Duijn E,
|
||
Giltay EJ,
|
||
Tibben A</span><br />
|
||
<span class="medgenPMjournal">J Genet Couns</span>
|
||
2015 Oct;24(5):862-71.
|
||
Epub 2015 Feb 3
|
||
doi: 10.1007/s10897-015-9822-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25641254" target="_blank">25641254</a><a href="/pmc/articles/PMC4564439" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15824369">Microbleeds in hereditary cerebral hemorrhage with amyloidosis-Dutch type.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van den Boom R,
|
||
Bornebroek M,
|
||
Behloul F,
|
||
van den Berg-Huysmans AA,
|
||
Haan J,
|
||
van Buchem MA</span><br />
|
||
<span class="medgenPMjournal">Neurology</span>
|
||
2005 Apr 12;64(7):1288-9.
|
||
doi: 10.1212/01.WNL.0000156946.44593.24.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15824369" target="_blank">15824369</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9450860">Distress in individuals facing predictive DNA testing for autosomal dominant late-onset disorders: comparing questionnaire results with in-depth interviews. Rotterdam/Leiden Genetics Workgroup.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">DudokdeWit AC,
|
||
Tibben A,
|
||
Duivenvoorden HJ,
|
||
Niermeijer MF,
|
||
Passchier J,
|
||
Trijsburg RW</span><br />
|
||
<span class="medgenPMjournal">Am J Med Genet</span>
|
||
1998 Jan 6;75(1):62-74.
|
||
doi: 10.1002/(sici)1096-8628(19980106)75:1<62::aid-ajmg14>3.0.co;2-q.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9450860" target="_blank">9450860</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8737926">Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D): I--A review of clinical, radiologic and genetic aspects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bornebroek M,
|
||
Haan J,
|
||
Maat-Schieman ML,
|
||
Van Duinen SG,
|
||
Roos RA</span><br />
|
||
<span class="medgenPMjournal">Brain Pathol</span>
|
||
1996 Apr;6(2):111-4.
|
||
doi: 10.1111/j.1750-3639.1996.tb00793.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8737926" target="_blank">8737926</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hereditary%20cerebral%20hemorrhage%20with%20amyloidosis%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (10)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33361604">Presymptomatic Dutch-Type Hereditary Cerebral Amyloid Angiopathy-Related Blood Metabolite Alterations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chatterjee P,
|
||
Fagan AM,
|
||
Xiong C,
|
||
McKay M,
|
||
Bhatnagar A,
|
||
Wu Y,
|
||
Singh AK,
|
||
Taddei K,
|
||
Martins I,
|
||
Gardener SL,
|
||
Molloy MP,
|
||
Multhaup G,
|
||
Masters CL,
|
||
Schofield PR,
|
||
Benzinger TLS,
|
||
Morris JC,
|
||
Bateman RJ,
|
||
Greenberg SM,
|
||
Wermer MJH,
|
||
van Buchem MA,
|
||
Sohrabi HR,
|
||
Martins RN;
|
||
Dominantly Inherited Alzheimer Network</span><br />
|
||
<span class="medgenPMjournal">J Alzheimers Dis</span>
|
||
2021;79(2):895-903.
|
||
doi: 10.3233/JAD-201267.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33361604" target="_blank">33361604</a><a href="/pmc/articles/PMC8057860" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30868685">Osteopontin and phospho-SMAD2/3 are associated with calcification of vessels in D-CAA, an hereditary cerebral amyloid angiopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Grand Moursel L,
|
||
van der Graaf LM,
|
||
Bulk M,
|
||
van Roon-Mom WMC,
|
||
van der Weerd L</span><br />
|
||
<span class="medgenPMjournal">Brain Pathol</span>
|
||
2019 Nov;29(6):793-802.
|
||
Epub 2019 Apr 4
|
||
doi: 10.1111/bpa.12721.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30868685" target="_blank">30868685</a><a href="/pmc/articles/PMC6850614" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30354978">Cerebral Amyloid Angiopathy With Vascular Iron Accumulation and Calcification.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bulk M,
|
||
Moursel LG,
|
||
van der Graaf LM,
|
||
van Veluw SJ,
|
||
Greenberg SM,
|
||
van Duinen SG,
|
||
van Buchem MA,
|
||
van Rooden S,
|
||
van der Weerd L</span><br />
|
||
<span class="medgenPMjournal">Stroke</span>
|
||
2018 Sep;49(9):2081-2087.
|
||
doi: 10.1161/STROKEAHA.118.021872.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30354978" target="_blank">30354978</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28557134">TGFβ pathway deregulation and abnormal phospho-SMAD2/3 staining in hereditary cerebral hemorrhage with amyloidosis-Dutch type.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Grand Moursel L,
|
||
Munting LP,
|
||
van der Graaf LM,
|
||
van Duinen SG,
|
||
Goumans MTH,
|
||
Ueberham U,
|
||
Natté R,
|
||
van Buchem MA,
|
||
van Roon-Mom WMC,
|
||
van der Weerd L</span><br />
|
||
<span class="medgenPMjournal">Brain Pathol</span>
|
||
2018 Jul;28(4):495-506.
|
||
Epub 2017 Jun 12
|
||
doi: 10.1111/bpa.12533.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28557134" target="_blank">28557134</a><a href="/pmc/articles/PMC8028662" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/14533778">Cerebral amyloid angiopathies: a pathologic, biochemical, and genetic view.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Revesz T,
|
||
Ghiso J,
|
||
Lashley T,
|
||
Plant G,
|
||
Rostagno A,
|
||
Frangione B,
|
||
Holton JL</span><br />
|
||
<span class="medgenPMjournal">J Neuropathol Exp Neurol</span>
|
||
2003 Sep;62(9):885-98.
|
||
doi: 10.1093/jnen/62.9.885.
|
||
<span class="bold">PMID: </span><a href="/pubmed/14533778" target="_blank">14533778</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hereditary%20cerebral%20hemorrhage%20with%20amyloidosis%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (45)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/28254515">Hereditary cerebral small vessel disease and stroke.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Søndergaard CB,
|
||
Nielsen JE,
|
||
Hansen CK,
|
||
Christensen H</span><br />
|
||
<span class="medgenPMjournal">Clin Neurol Neurosurg</span>
|
||
2017 Apr;155:45-57.
|
||
Epub 2017 Feb 22
|
||
doi: 10.1016/j.clineuro.2017.02.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28254515" target="_blank">28254515</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hereditary%20cerebral%20hemorrhage%20with%20amyloidosis%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
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|
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|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22hereditary%20cerebral%20hemorrhage%20with%20amyloidosis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Hereditary%20cerebral%20hemorrhage%20with%20amyloidosis%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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