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<meta name="keywords" content="C1168401, carcinoma, squamous cell of head and neck, craniocervical region squamous cell carcinoma, head and neck squamous cell carcinoma, head and neck squamous cell carcinomas, hnscc, ing1, neoplastic process, scchn, squamous cell carcinoma of head and neck, squamous cell carcinoma of the head and neck, squamous cell carcinoma, head and neck, squamous cell carcinoma, head and neck, somatic, squamous cell carcinomas of head and neck, tnfrsf10b, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells. Squamous cells are found in the outer layer of skin and in the mucous membranes, which are the moist tissues that line body cavities such as the airways and intestines. Head and neck squamous cell carcinoma (HNSCC) develops in the mucous membranes of the mouth, nose, and throat.\n\nHNSCC is classified by its location: it can occur in the mouth (oral cavity), the middle part of the throat near the mouth (oropharynx), the space behind the nose (nasal cavity and paranasal sinuses), the upper part of the throat near the nasal cavity (nasopharynx), the voicebox (larynx), or the lower part of the throat near the larynx (hypopharynx). Depending on the location, the cancer can cause abnormal patches or open sores (ulcers) in the mouth and throat, unusual bleeding or pain in the mouth, sinus congestion that does not clear, sore throat, earache, pain when swallowing or difficulty swallowing, a hoarse voice, difficulty breathing, or enlarged lymph nodes.\n\nHNSCC can spread (metastasize) to other parts of the body, such as the lymph nodes or lungs. If it spreads, the cancer has a worse prognosis and can be fatal. About half of affected individuals survive more than five years after diagnosis." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Squamous cell carcinoma of the head and neck (Concept Id: C1168401)
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<!--
UID=257911
ConceptID=C1168401
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Squamous cell carcinoma of the head and neck<span class="h1sub">(HNSCC)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>257911</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C1168401</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Carcinoma, squamous cell of head and neck; Head and neck squamous cell carcinoma; HNSCC; Squamous cell carcinoma, head and neck, somatic</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Squamous cell carcinoma of head and neck (716659002)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Genes (locations):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
Gene(s) directly associated with<br />
this condition or phenotype.</div></td>
<td><a target="_blank" title="ING1 - ID: 3621 - NCBI Gene" href="/gene/3621" class="medgenPMinfo">ING1</a> (13q34); <a target="_blank" title="TNFRSF10B - ID: 8795 - NCBI Gene" href="/gene/8795" class="medgenPMinfo">TNFRSF10B</a> (8p21.3)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0010150" target="_blank">MONDO:0010150</a></td></tr>
<tr><td>OMIM<span class="superscript">®</span>:</td>
<td><a href="https://omim.org/entry/275355" target="_blank">275355</a></td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells. Squamous cells are found in the outer layer of skin and in the mucous membranes, which are the moist tissues that line body cavities such as the airways and intestines. Head and neck squamous cell carcinoma (HNSCC) develops in the mucous membranes of the mouth, nose, and throat.<br /><br />HNSCC is classified by its location: it can occur in the mouth (oral cavity), the middle part of the throat near the mouth (oropharynx), the space behind the nose (nasal cavity and paranasal sinuses), the upper part of the throat near the nasal cavity (nasopharynx), the voicebox (larynx), or the lower part of the throat near the larynx (hypopharynx). Depending on the location, the cancer can cause abnormal patches or open sores (ulcers) in the mouth and throat, unusual bleeding or pain in the mouth, sinus congestion that does not clear, sore throat, earache, pain when swallowing or difficulty swallowing, a hoarse voice, difficulty breathing, or enlarged lymph nodes.<br /><br />HNSCC can spread (metastasize) to other parts of the body, such as the lymph nodes or lungs. If it spreads, the cancer has a worse prognosis and can be fatal. About half of affected individuals survive more than five years after diagnosis. [from <a title="MedlinePlus Genetics" href="https://medlineplus.gov/genetics/" class="defSource" target="_blank">MedlinePlus Genetics</a>]</div>
</div>
<div class="portlet mgSection" id="ID_102">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
<div class="divPopper rprt" id="clin_2874"><div><strong>Squamous cell carcinoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>2874</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0007137</a></dd><dt><span class="dotprefix"></span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
<div class="spaceAbove">The presence of squamous cell carcinoma of the skin.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/2874">Feature record</a> | <a href="/medgen?term=%22Squamous%20cell%20carcinoma%22%5BClinical%20Features%5D%20OR%202874%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Neoplasm</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_2874" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Squamous cell carcinoma</a></span></li></ul></li></ul></div></div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1168401[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=257911">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=257911" target="_blank" href="/omim/275355">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=257911" ref="ncbi_uid=257911">V</a></span></span><span class="TLline">Squamous cell carcinoma of the head and neck</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/277963" ref="tree=MeSH" title="MedGen record for Epithelial neoplasm">Epithelial neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/2867" ref="tree=MeSH" title="MedGen record for Carcinoma">Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/854345" ref="tree=MeSH" title="MedGen record for Head and neck carcinoma">Head and neck carcinoma</a></span><ul><li><span class="matched_ds">Squamous cell carcinoma of the head and neck</span><ul><li><span class="TLline"><a href="/medgen/1705140" ref="tree=MeSH" title="MedGen record for ASPH-Positive Head and Neck Squamous Cell Carcinoma">ASPH-Positive Head and Neck Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1614715" ref="tree=MeSH" title="MedGen record for Cutaneous Squamous Cell Carcinoma of the Head and Neck">Cutaneous Squamous Cell Carcinoma of the Head and Neck</a></span><ul><li><span class="TLline"><a href="/medgen/1617614" ref="tree=MeSH" title="MedGen record for Cutaneous Squamous Cell Carcinoma of the Head and Neck by AJCC v8 Stage">Cutaneous Squamous Cell Carcinoma of the Head and Neck by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1623983" ref="tree=MeSH" title="MedGen record for Stage 0 Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8">Stage 0 Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1622300" ref="tree=MeSH" title="MedGen record for Stage I Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8">Stage I Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1616439" ref="tree=MeSH" title="MedGen record for Stage II Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8">Stage II Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1611653" ref="tree=MeSH" title="MedGen record for Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8">Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1614442" ref="tree=MeSH" title="MedGen record for Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8">Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/232478" ref="tree=MeSH" title="MedGen record for External ear squamous cell carcinoma">External ear squamous cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1733748" ref="tree=MeSH" title="MedGen record for Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck">Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck</a></span><ul><li><span class="TLline"><a href="/medgen/1770888" ref="tree=MeSH" title="MedGen record for Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck">Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck</a></span></li><li><span class="TLline"><a href="/medgen/1793136" ref="tree=MeSH" title="MedGen record for Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck">Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1691326" ref="tree=MeSH" title="MedGen record for Recurrent Cutaneous Squamous Cell Carcinoma of the Head and Neck">Recurrent Cutaneous Squamous Cell Carcinoma of the Head and Neck</a></span></li><li><span class="TLline"><a href="/medgen/1728246" ref="tree=MeSH" title="MedGen record for Refractory Cutaneous Squamous Cell Carcinoma of the Head and Neck">Refractory Cutaneous Squamous Cell Carcinoma of the Head and Neck</a></span></li><li><span class="TLline"><a href="/medgen/1694931" ref="tree=MeSH" title="MedGen record for Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck">Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/234337" ref="tree=MeSH" title="MedGen record for Head and Neck Basaloid Squamous Cell Carcinoma">Head and Neck Basaloid Squamous Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1382431" ref="tree=MeSH" title="MedGen record for Floor of Mouth Basaloid Squamous Cell Carcinoma">Floor of Mouth Basaloid Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/353839" ref="tree=MeSH" title="MedGen record for Laryngeal Basaloid Squamous Cell Carcinoma">Laryngeal Basaloid Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/328304" ref="tree=MeSH" title="MedGen record for Nasopharyngeal Basaloid Squamous Cell Carcinoma">Nasopharyngeal Basaloid Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/926083" ref="tree=MeSH" title="MedGen record for Oropharyngeal Basaloid Squamous Cell Carcinoma">Oropharyngeal Basaloid Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/317808" ref="tree=MeSH" title="MedGen record for Head and Neck Keratinizing Squamous Cell Carcinoma">Head and Neck Keratinizing Squamous Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/272785" ref="tree=MeSH" title="MedGen record for Keratinizing Primary Intraosseous Squamous Cell Carcinoma-Solid Type">Keratinizing Primary Intraosseous Squamous Cell Carcinoma-Solid Type</a></span></li><li><span class="TLline"><a href="/medgen/233191" ref="tree=MeSH" title="MedGen record for Middle ear squamous cell carcinoma">Middle ear squamous cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1708895" ref="tree=MeSH" title="MedGen record for Nasopharyngeal Keratinizing Squamous Cell Carcinoma">Nasopharyngeal Keratinizing Squamous Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1663213" ref="tree=MeSH" title="MedGen record for Metastatic Nasopharyngeal Keratinizing Squamous Cell Carcinoma">Metastatic Nasopharyngeal Keratinizing Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1717441" ref="tree=MeSH" title="MedGen record for Recurrent Nasopharyngeal Keratinizing Squamous Cell Carcinoma">Recurrent Nasopharyngeal Keratinizing Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1621368" ref="tree=MeSH" title="MedGen record for Stage 0 Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v6, v7, and v8">Stage 0 Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v6, v7, and v8</a></span></li><li><span class="TLline"><a href="/medgen/79110" ref="tree=MeSH" title="MedGen record for Stage I Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7">Stage I Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/124733" ref="tree=MeSH" title="MedGen record for Stage II Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7">Stage II Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/83643" ref="tree=MeSH" title="MedGen record for Stage III Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7">Stage III Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1653060" ref="tree=MeSH" title="MedGen record for Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7">Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1752101" ref="tree=MeSH" title="MedGen record for Sinonasal Keratinizing Squamous Cell Carcinoma">Sinonasal Keratinizing Squamous Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/318530" ref="tree=MeSH" title="MedGen record for Nasal Cavity Keratinizing Squamous Cell Carcinoma">Nasal Cavity Keratinizing Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/353830" ref="tree=MeSH" title="MedGen record for Paranasal Sinus Keratinizing Squamous Cell Carcinoma">Paranasal Sinus Keratinizing Squamous Cell Carcinoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1769546" ref="tree=MeSH" title="MedGen record for Human Papillomavirus-Related Mucosal Head and Neck Squamous Cell Carcinoma">Human Papillomavirus-Related Mucosal Head and Neck Squamous Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/415751" ref="tree=MeSH" title="MedGen record for Oropharyngeal Human Papillomavirus-Related Squamous Cell Carcinoma">Oropharyngeal Human Papillomavirus-Related Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1739108" ref="tree=MeSH" title="MedGen record for Sinonasal Human Papillomavirus-Related Multiphenotypic Carcinoma">Sinonasal Human Papillomavirus-Related Multiphenotypic Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/83630" ref="tree=MeSH" title="MedGen record for Laryngeal squamous cell carcinoma">Laryngeal squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/76096" ref="tree=MeSH" title="MedGen record for Glottis squamous cell carcinoma">Glottis squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/83631" ref="tree=MeSH" title="MedGen record for Glottis verrucous carcinoma">Glottis verrucous carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/313337" ref="tree=MeSH" title="MedGen record for Laryngeal Acantholytic Squamous Cell Carcinoma">Laryngeal Acantholytic Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/473519" ref="tree=MeSH" title="MedGen record for Laryngeal Papillary Squamous Cell Carcinoma">Laryngeal Papillary Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/310918" ref="tree=MeSH" title="MedGen record for Laryngeal Spindle Cell Squamous Carcinoma">Laryngeal Spindle Cell Squamous Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/76097" ref="tree=MeSH" title="MedGen record for Larynx verrucous carcinoma">Larynx verrucous carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/124738" ref="tree=MeSH" title="MedGen record for Recurrent Laryngeal Verrucous Carcinoma">Recurrent Laryngeal Verrucous Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/236848" ref="tree=MeSH" title="MedGen record for Stage 0 Laryngeal Verrucous Carcinoma AJCC v6, v7, and v8">Stage 0 Laryngeal Verrucous Carcinoma AJCC v6, v7, and v8</a></span></li><li><span class="TLline"><a href="/medgen/1615091" ref="tree=MeSH" title="MedGen record for Stage I Laryngeal Verrucous Carcinoma AJCC v6 and v7">Stage I Laryngeal Verrucous Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1617416" ref="tree=MeSH" title="MedGen record for Stage II Laryngeal Verrucous Carcinoma AJCC v6 and v7">Stage II Laryngeal Verrucous Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1626613" ref="tree=MeSH" title="MedGen record for Stage III Laryngeal Verrucous Carcinoma AJCC v6 and v7">Stage III Laryngeal Verrucous Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/124737" ref="tree=MeSH" title="MedGen record for Stage IV Laryngeal Verrucous Carcinoma AJCC v7">Stage IV Laryngeal Verrucous Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/124721" ref="tree=MeSH" title="MedGen record for Subglottis verrucous carcinoma">Subglottis verrucous carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/76098" ref="tree=MeSH" title="MedGen record for Supraglottis verrucous carcinoma">Supraglottis verrucous carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/83649" ref="tree=MeSH" title="MedGen record for Metastatic Laryngeal Squamous Cell Carcinoma">Metastatic Laryngeal Squamous Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1665175" ref="tree=MeSH" title="MedGen record for Advanced Laryngeal Squamous Cell Carcinoma">Advanced Laryngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1712205" ref="tree=MeSH" title="MedGen record for Locally Advanced Laryngeal Squamous Cell Carcinoma">Locally Advanced Laryngeal Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/79114" ref="tree=MeSH" title="MedGen record for Recurrent Laryngeal Squamous Cell Carcinoma">Recurrent Laryngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1654726" ref="tree=MeSH" title="MedGen record for Refractory Laryngeal Squamous Cell Carcinoma">Refractory Laryngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1619618" ref="tree=MeSH" title="MedGen record for Stage 0 Laryngeal Squamous Cell Carcinoma AJCC v6, v7, and v8">Stage 0 Laryngeal Squamous Cell Carcinoma AJCC v6, v7, and v8</a></span><ul><li><span class="TLline"><a href="/medgen/1624733" ref="tree=MeSH" title="MedGen record for Stage 0 Epiglottic Carcinoma AJCC v6, v7, and v8">Stage 0 Epiglottic Carcinoma AJCC v6, v7, and v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1620522" ref="tree=MeSH" title="MedGen record for Stage I Laryngeal Squamous Cell Carcinoma AJCC v6 and v7">Stage I Laryngeal Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1624646" ref="tree=MeSH" title="MedGen record for Stage II Laryngeal Squamous Cell Carcinoma AJCC v6 and v7">Stage II Laryngeal Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1620020" ref="tree=MeSH" title="MedGen record for Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7">Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1656464" ref="tree=MeSH" title="MedGen record for Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7">Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/234866" ref="tree=MeSH" title="MedGen record for Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7">Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/234872" ref="tree=MeSH" title="MedGen record for Stage IVB Laryngeal Squamous Cell Carcinoma AJCC v7">Stage IVB Laryngeal Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/233527" ref="tree=MeSH" title="MedGen record for Stage IVC Laryngeal Squamous Cell Carcinoma AJCC v7">Stage IVC Laryngeal Squamous Cell Carcinoma AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/124720" ref="tree=MeSH" title="MedGen record for Subglottis squamous cell carcinoma">Subglottis squamous cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/152890" ref="tree=MeSH" title="MedGen record for Supraglottis squamous cell carcinoma">Supraglottis squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1793656" ref="tree=MeSH" title="MedGen record for Epiglottic Squamous Cell Carcinoma">Epiglottic Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1732482" ref="tree=MeSH" title="MedGen record for Unresectable Laryngeal Squamous Cell Carcinoma">Unresectable Laryngeal Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/124714" ref="tree=MeSH" title="MedGen record for Lip and oral cavity squamous cell carcinoma">Lip and oral cavity squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/108436" ref="tree=MeSH" title="MedGen record for Oral cavity squamous cell carcinoma">Oral cavity squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1749749" ref="tree=MeSH" title="MedGen record for Alveolar Ridge Squamous Cell Carcinoma">Alveolar Ridge Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1376455" ref="tree=MeSH" title="MedGen record for Gingival Squamous Cell Carcinoma">Gingival Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1670371" ref="tree=MeSH" title="MedGen record for Metastatic Oral Cavity Squamous Cell Carcinoma">Metastatic Oral Cavity Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/91154" ref="tree=MeSH" title="MedGen record for Palate Squamous Cell Carcinoma">Palate Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/313618" ref="tree=MeSH" title="MedGen record for Primary intraosseous squamous cell carcinoma">Primary intraosseous squamous cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/163573" ref="tree=MeSH" title="MedGen record for Recurrent Oral Cavity Squamous Cell Carcinoma">Recurrent Oral Cavity Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1650027" ref="tree=MeSH" title="MedGen record for Refractory Oral Cavity Squamous Cell Carcinoma">Refractory Oral Cavity Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/83627" ref="tree=MeSH" title="MedGen record for Squamous cell carcinoma of buccal mucosa">Squamous cell carcinoma of buccal mucosa</a></span></li><li><span class="TLline"><a href="/medgen/124715" ref="tree=MeSH" title="MedGen record for Squamous cell carcinoma of floor of mouth">Squamous cell carcinoma of floor of mouth</a></span></li><li><span class="TLline"><a href="/medgen/91153" ref="tree=MeSH" title="MedGen record for Squamous cell carcinoma of the tongue">Squamous cell carcinoma of the tongue</a></span></li><li><span class="TLline"><a href="/medgen/163659" ref="tree=MeSH" title="MedGen record for Stage 0 Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7">Stage 0 Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/167827" ref="tree=MeSH" title="MedGen record for Stage I Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7">Stage I Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/167828" ref="tree=MeSH" title="MedGen record for Stage II Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7">Stage II Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/163660" ref="tree=MeSH" title="MedGen record for Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7">Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/163661" ref="tree=MeSH" title="MedGen record for Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7">Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1748904" ref="tree=MeSH" title="MedGen record for Unresectable Oral Cavity Squamous Cell Carcinoma">Unresectable Oral Cavity Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/124716" ref="tree=MeSH" title="MedGen record for Verrucous carcinoma of oral cavity">Verrucous carcinoma of oral cavity</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/852486" ref="tree=MeSH" title="MedGen record for Recurrent Lip and Oral Cavity Squamous Cell Carcinoma">Recurrent Lip and Oral Cavity Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/79099" ref="tree=MeSH" title="MedGen record for Squamous cell carcinoma of lip">Squamous cell carcinoma of lip</a></span><ul><li><span class="TLline"><a href="/medgen/1659624" ref="tree=MeSH" title="MedGen record for Metastatic Lip Squamous Cell Carcinoma">Metastatic Lip Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/852482" ref="tree=MeSH" title="MedGen record for Stage I Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7">Stage I Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/852483" ref="tree=MeSH" title="MedGen record for Stage II Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7">Stage II Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/852484" ref="tree=MeSH" title="MedGen record for Stage III Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7">Stage III Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/852485" ref="tree=MeSH" title="MedGen record for Stage IV Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7">Stage IV Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7</a></span><ul><li><span class="TLline"><a href="/medgen/857117" ref="tree=MeSH" title="MedGen record for Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7">Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/857110" ref="tree=MeSH" title="MedGen record for Stage IVB Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7">Stage IVB Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/857104" ref="tree=MeSH" title="MedGen record for Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7">Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1660276" ref="tree=MeSH" title="MedGen record for Metastatic Head and Neck Squamous Cell Carcinoma">Metastatic Head and Neck Squamous Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1619962" ref="tree=MeSH" title="MedGen record for Advanced Head and Neck Squamous Cell Carcinoma">Advanced Head and Neck Squamous Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1650313" ref="tree=MeSH" title="MedGen record for Advanced Oral Cavity Squamous Cell Carcinoma">Advanced Oral Cavity Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1769475" ref="tree=MeSH" title="MedGen record for Advanced Pharyngeal Squamous Cell Carcinoma">Advanced Pharyngeal Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1701136" ref="tree=MeSH" title="MedGen record for Locally Advanced Head and Neck Squamous Cell Carcinoma">Locally Advanced Head and Neck Squamous Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1713861" ref="tree=MeSH" title="MedGen record for Locally Advanced Hypopharyngeal Squamous Cell Carcinoma">Locally Advanced Hypopharyngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1712139" ref="tree=MeSH" title="MedGen record for Locally Advanced Nasopharyngeal Squamous Cell Carcinoma">Locally Advanced Nasopharyngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1719991" ref="tree=MeSH" title="MedGen record for Locally Advanced Oral Cavity Squamous Cell Carcinoma">Locally Advanced Oral Cavity Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1693245" ref="tree=MeSH" title="MedGen record for Locally Advanced Oropharyngeal Squamous Cell Carcinoma">Locally Advanced Oropharyngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1652282" ref="tree=MeSH" title="MedGen record for Locally Advanced Sinonasal Squamous Cell Carcinoma">Locally Advanced Sinonasal Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1768945" ref="tree=MeSH" title="MedGen record for Metastatic Pharyngeal Squamous Cell Carcinoma">Metastatic Pharyngeal Squamous Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/79113" ref="tree=MeSH" title="MedGen record for Metastatic Hypopharyngeal Squamous Cell Carcinoma">Metastatic Hypopharyngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1653175" ref="tree=MeSH" title="MedGen record for Metastatic Nasopharyngeal Squamous Cell Carcinoma">Metastatic Nasopharyngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/124732" ref="tree=MeSH" title="MedGen record for Metastatic Oropharyngeal Squamous Cell Carcinoma">Metastatic Oropharyngeal Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1762905" ref="tree=MeSH" title="MedGen record for Metastatic Salivary Gland Squamous Cell Carcinoma">Metastatic Salivary Gland Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1701061" ref="tree=MeSH" title="MedGen record for Metastatic Sinonasal Squamous Cell Carcinoma">Metastatic Sinonasal Squamous Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1715835" ref="tree=MeSH" title="MedGen record for Metastatic Nasal Cavity Squamous Cell Carcinoma">Metastatic Nasal Cavity Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1698969" ref="tree=MeSH" title="MedGen record for Metastatic Paranasal Sinus Squamous Cell Carcinoma">Metastatic Paranasal Sinus Squamous Cell Carcinoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/124722" ref="tree=MeSH" title="MedGen record for Nasal cavity and paranasal sinus squamous cell carcinoma">Nasal cavity and paranasal sinus squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/79104" ref="tree=MeSH" title="MedGen record for Nasal cavity squamous cell carcinoma">Nasal cavity squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1787420" ref="tree=MeSH" title="MedGen record for Unresectable Nasal Cavity Squamous Cell Carcinoma">Unresectable Nasal Cavity Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/83119" ref="tree=MeSH" title="MedGen record for Non-keratinizing sinonasal squamous cell carcinoma">Non-keratinizing sinonasal squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1765517" ref="tree=MeSH" title="MedGen record for Sinonasal Lymphoepithelial Carcinoma">Sinonasal Lymphoepithelial Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/79105" ref="tree=MeSH" title="MedGen record for Paranasal sinus squamous cell carcinoma">Paranasal sinus squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/272596" ref="tree=MeSH" title="MedGen record for Ethmoid sinus squamous cell carcinoma">Ethmoid sinus squamous cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/272639" ref="tree=MeSH" title="MedGen record for Frontal sinus squamous cell carcinoma">Frontal sinus squamous cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/277348" ref="tree=MeSH" title="MedGen record for Maxillary sinus squamous cell carcinoma">Maxillary sinus squamous cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1649419" ref="tree=MeSH" title="MedGen record for Recurrent Paranasal Sinus Squamous Cell Carcinoma">Recurrent Paranasal Sinus Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1668041" ref="tree=MeSH" title="MedGen record for Refractory Paranasal Sinus Squamous Cell Carcinoma">Refractory Paranasal Sinus Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/234802" ref="tree=MeSH" title="MedGen record for Sphenoid sinus squamous cell carcinoma">Sphenoid sinus squamous cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1764557" ref="tree=MeSH" title="MedGen record for Unresectable Paranasal Sinus Squamous Cell Carcinoma">Unresectable Paranasal Sinus Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/852494" ref="tree=MeSH" title="MedGen record for Recurrent Sinonasal Squamous Cell Carcinoma">Recurrent Sinonasal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1661272" ref="tree=MeSH" title="MedGen record for Refractory Sinonasal Squamous Cell Carcinoma">Refractory Sinonasal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1734714" ref="tree=MeSH" title="MedGen record for Sinonasal Spindle Cell Squamous Carcinoma">Sinonasal Spindle Cell Squamous Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1625233" ref="tree=MeSH" title="MedGen record for Stage I Sinonasal Squamous Cell Carcinoma AJCC v6 and v7">Stage I Sinonasal Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1611675" ref="tree=MeSH" title="MedGen record for Stage II Sinonasal Squamous Cell Carcinoma AJCC v6 and v7">Stage II Sinonasal Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1618753" ref="tree=MeSH" title="MedGen record for Stage III Sinonasal Squamous Cell Carcinoma AJCC v6 and v7">Stage III Sinonasal Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/852493" ref="tree=MeSH" title="MedGen record for Stage IV Sinonasal Squamous Cell Carcinoma AJCC v7">Stage IV Sinonasal Squamous Cell Carcinoma AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/857116" ref="tree=MeSH" title="MedGen record for Stage IVA Sinonasal Squamous Cell Carcinoma AJCC v7">Stage IVA Sinonasal Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/857109" ref="tree=MeSH" title="MedGen record for Stage IVB Sinonasal Squamous Cell Carcinoma AJCC v7">Stage IVB Sinonasal Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/857103" ref="tree=MeSH" title="MedGen record for Stage IVC Sinonasal Squamous Cell Carcinoma AJCC v7">Stage IVC Sinonasal Squamous Cell Carcinoma AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1778363" ref="tree=MeSH" title="MedGen record for Unresectable Sinonasal Squamous Cell Carcinoma">Unresectable Sinonasal Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/728086" ref="tree=MeSH" title="MedGen record for Pharyngeal squamous cell carcinoma">Pharyngeal squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/79102" ref="tree=MeSH" title="MedGen record for Hypopharynx squamous cell carcinoma">Hypopharynx squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/79103" ref="tree=MeSH" title="MedGen record for Postcricoid Squamous Cell Carcinoma">Postcricoid Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/196666" ref="tree=MeSH" title="MedGen record for Pyriform Fossa Squamous Cell Carcinoma">Pyriform Fossa Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/83646" ref="tree=MeSH" title="MedGen record for Recurrent Hypopharyngeal Squamous Cell Carcinoma">Recurrent Hypopharyngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1665403" ref="tree=MeSH" title="MedGen record for Refractory Hypopharyngeal Squamous Cell Carcinoma">Refractory Hypopharyngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1615274" ref="tree=MeSH" title="MedGen record for Stage 0 Hypopharyngeal Squamous Cell Carcinoma AJCC v6, v7, and v8">Stage 0 Hypopharyngeal Squamous Cell Carcinoma AJCC v6, v7, and v8</a></span></li><li><span class="TLline"><a href="/medgen/76106" ref="tree=MeSH" title="MedGen record for Stage I Hypopharyngeal Squamous Cell Carcinoma AJCC v7">Stage I Hypopharyngeal Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/79111" ref="tree=MeSH" title="MedGen record for Stage II Hypopharyngeal Squamous Cell Carcinoma AJCC v6 and v7">Stage II Hypopharyngeal Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/79112" ref="tree=MeSH" title="MedGen record for Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7">Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1658434" ref="tree=MeSH" title="MedGen record for Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7">Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1777191" ref="tree=MeSH" title="MedGen record for Unresectable Hypopharyngeal Squamous Cell Carcinoma">Unresectable Hypopharyngeal Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/76017" ref="tree=MeSH" title="MedGen record for Nasopharyngeal squamous cell carcinoma">Nasopharyngeal squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/277408" ref="tree=MeSH" title="MedGen record for Nasopharyngeal Non-Keratinizing Carcinoma">Nasopharyngeal Non-Keratinizing Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/76105" ref="tree=MeSH" title="MedGen record for Recurrent Nasopharyngeal Squamous Cell Carcinoma">Recurrent Nasopharyngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1737201" ref="tree=MeSH" title="MedGen record for Unresectable Nasopharyngeal Squamous Cell Carcinoma">Unresectable Nasopharyngeal Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/76094" ref="tree=MeSH" title="MedGen record for Oropharyngeal squamous cell carcinoma">Oropharyngeal squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1755712" ref="tree=MeSH" title="MedGen record for Oropharyngeal Human Papillomavirus-Independent Squamous Cell Carcinoma">Oropharyngeal Human Papillomavirus-Independent Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1636921" ref="tree=MeSH" title="MedGen record for Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma">Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/926082" ref="tree=MeSH" title="MedGen record for Oropharyngeal Poorly Differentiated Carcinoma">Oropharyngeal Poorly Differentiated Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/76095" ref="tree=MeSH" title="MedGen record for Oropharyngeal Undifferentiated Carcinoma">Oropharyngeal Undifferentiated Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/79109" ref="tree=MeSH" title="MedGen record for Recurrent Oropharyngeal Squamous Cell Carcinoma">Recurrent Oropharyngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1669285" ref="tree=MeSH" title="MedGen record for Refractory Oropharyngeal Squamous Cell Carcinoma">Refractory Oropharyngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1694101" ref="tree=MeSH" title="MedGen record for Resectable Oropharyngeal Squamous Cell Carcinoma">Resectable Oropharyngeal Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/148181" ref="tree=MeSH" title="MedGen record for Soft Palate Squamous Cell Carcinoma">Soft Palate Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/163662" ref="tree=MeSH" title="MedGen record for Stage 0 Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7">Stage 0 Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/76103" ref="tree=MeSH" title="MedGen record for Stage I Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7">Stage I Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/83640" ref="tree=MeSH" title="MedGen record for Stage II Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7">Stage II Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/124731" ref="tree=MeSH" title="MedGen record for Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7">Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1669998" ref="tree=MeSH" title="MedGen record for Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7">Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/79101" ref="tree=MeSH" title="MedGen record for Tonsillar squamous cell carcinoma">Tonsillar squamous cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1704184" ref="tree=MeSH" title="MedGen record for Unresectable Oropharyngeal Squamous Cell Carcinoma">Unresectable Oropharyngeal Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/233867" ref="tree=MeSH" title="MedGen record for Posterior Pharyngeal Wall Squamous Cell Carcinoma">Posterior Pharyngeal Wall Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1753201" ref="tree=MeSH" title="MedGen record for Recurrent Pharyngeal Squamous Cell Carcinoma">Recurrent Pharyngeal Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1621629" ref="tree=MeSH" title="MedGen record for Recurrent Head and Neck Squamous Cell Carcinoma">Recurrent Head and Neck Squamous Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1784906" ref="tree=MeSH" title="MedGen record for Locally Recurrent Head and Neck Squamous Cell Carcinoma">Locally Recurrent Head and Neck Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1730212" ref="tree=MeSH" title="MedGen record for Recurrent Salivary Gland Squamous Cell Carcinoma">Recurrent Salivary Gland Squamous Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1664330" ref="tree=MeSH" title="MedGen record for Recurrent Parotid Gland Squamous Cell Carcinoma">Recurrent Parotid Gland Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1658140" ref="tree=MeSH" title="MedGen record for Recurrent Submandibular Gland Squamous Cell Carcinoma">Recurrent Submandibular Gland Squamous Cell Carcinoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1655619" ref="tree=MeSH" title="MedGen record for Refractory Head and Neck Squamous Cell Carcinoma">Refractory Head and Neck Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1372955" ref="tree=MeSH" title="MedGen record for Resectable Head and Neck Squamous Cell Carcinoma">Resectable Head and Neck Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/83545" ref="tree=MeSH" title="MedGen record for Salivary gland squamous cell carcinoma">Salivary gland squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1793310" ref="tree=MeSH" title="MedGen record for Major Salivary Gland Squamous Cell Carcinoma">Major Salivary Gland Squamous Cell Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/233317" ref="tree=MeSH" title="MedGen record for Parotid gland squamous cell carcinoma">Parotid gland squamous cell carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/277775" ref="tree=MeSH" title="MedGen record for Submandibular Gland Squamous Cell Carcinoma">Submandibular Gland Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/233712" ref="tree=MeSH" title="MedGen record for Minor Salivary Gland Squamous Cell Carcinoma">Minor Salivary Gland Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/417024" ref="tree=MeSH" title="MedGen record for Salivary Gland Poorly Differentiated Squamous Cell Carcinoma">Salivary Gland Poorly Differentiated Squamous Cell Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1771591" ref="tree=MeSH" title="MedGen record for Unresectable Salivary Gland Squamous Cell Carcinoma">Unresectable Salivary Gland Squamous Cell Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1613385" ref="tree=MeSH" title="MedGen record for Unresectable Head and Neck Squamous Cell Carcinoma">Unresectable Head and Neck Squamous Cell Carcinoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&amp;data_id=156&amp;PatId=10898&amp;search=Disease_Classif_Simple&amp;new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Squamous cell carcinoma of the head and neck</span> in Orphanet.</div></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/34597438">Eligibility criteria for programmed death receptor 1 inhibitors vs. real-world advice: a retrospective analysis of 69 patients with advanced cutaneous squamous cell carcinoma of the head and neck.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Leus AJG,
Horváth B,
Terra JB,
Diercks GFH,
Plaat BEC,
Oosting SF,
Rácz E</span><br />
<span class="medgenPMjournal">Br J Dermatol</span>
2022 Feb;186(2):371-372.
Epub 2021 Nov 2
doi: 10.1111/bjd.20774.
<span class="bold">PMID: </span><a href="/pubmed/34597438" target="_blank">34597438</a><a href="/pmc/articles/PMC9298061" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32289475">Head and Neck Cancer International Group (HNCIG) Consensus Guidelines for the Delivery of Postoperative Radiation Therapy in Complex Cutaneous Squamous Cell Carcinoma of the Head and Neck (cSCCHN).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Porceddu SV,
Daniels C,
Yom SS,
Liu H,
Waldron J,
Gregoire V,
Moore A,
Veness M,
Yao M,
Johansen J,
Mehanna H,
Rischin D,
Le QT</span><br />
<span class="medgenPMjournal">Int J Radiat Oncol Biol Phys</span>
2020 Jul 15;107(4):641-651.
Epub 2020 Apr 11
doi: 10.1016/j.ijrobp.2020.03.024.
<span class="bold">PMID: </span><a href="/pubmed/32289475" target="_blank">32289475</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19454430">Squamous cell carcinoma of the head and neck: ESMO clinical recommendations for diagnosis, treatment and follow-up.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Licitra L,
Felip E;
ESMO Guidelines Working Group</span><br />
<span class="medgenPMjournal">Ann Oncol</span>
2009 May;20 Suppl 4:121-2.
doi: 10.1093/annonc/mdp149.
<span class="bold">PMID: </span><a href="/pubmed/19454430" target="_blank">19454430</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22squamous%20cell%20carcinoma%20of%20the%20head%20and%20neck%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (351)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/36796234">Extended follow-up of a phase 2 trial of xevinapant plus chemoradiotherapy in high-risk locally advanced squamous cell carcinoma of the head and neck: a randomised clinical trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tao Y,
Sun XS,
Pointreau Y,
Le Tourneau C,
Sire C,
Kaminsky MC,
Coutte A,
Alfonsi M,
Calderon B,
Boisselier P,
Martin L,
Miroir J,
Ramee JF,
Delord JP,
Clatot F,
Rolland F,
Villa J,
Magne N,
Elicin O,
Gherga E,
Nguyen F,
Lafond C,
Bera G,
Calugaru V,
Geoffrois L,
Chauffert B,
Damstrup L,
Crompton P,
Ennaji A,
Gollmer K,
Nauwelaerts H,
Bourhis J</span><br />
<span class="medgenPMjournal">Eur J Cancer</span>
2023 Apr;183:24-37.
Epub 2023 Jan 9
doi: 10.1016/j.ejca.2022.12.015.
<span class="bold">PMID: </span><a href="/pubmed/36796234" target="_blank">36796234</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32289475">Head and Neck Cancer International Group (HNCIG) Consensus Guidelines for the Delivery of Postoperative Radiation Therapy in Complex Cutaneous Squamous Cell Carcinoma of the Head and Neck (cSCCHN).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Porceddu SV,
Daniels C,
Yom SS,
Liu H,
Waldron J,
Gregoire V,
Moore A,
Veness M,
Yao M,
Johansen J,
Mehanna H,
Rischin D,
Le QT</span><br />
<span class="medgenPMjournal">Int J Radiat Oncol Biol Phys</span>
2020 Jul 15;107(4):641-651.
Epub 2020 Apr 11
doi: 10.1016/j.ijrobp.2020.03.024.
<span class="bold">PMID: </span><a href="/pubmed/32289475" target="_blank">32289475</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27718784">Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ferris RL,
Blumenschein G Jr,
Fayette J,
Guigay J,
Colevas AD,
Licitra L,
Harrington K,
Kasper S,
Vokes EE,
Even C,
Worden F,
Saba NF,
Iglesias Docampo LC,
Haddad R,
Rordorf T,
Kiyota N,
Tahara M,
Monga M,
Lynch M,
Geese WJ,
Kopit J,
Shaw JW,
Gillison ML</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2016 Nov 10;375(19):1856-1867.
Epub 2016 Oct 8
doi: 10.1056/NEJMoa1602252.
<span class="bold">PMID: </span><a href="/pubmed/27718784" target="_blank">27718784</a><a href="/pmc/articles/PMC5564292" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18784101">Platinum-based chemotherapy plus cetuximab in head and neck cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Vermorken JB,
Mesia R,
Rivera F,
Remenar E,
Kawecki A,
Rottey S,
Erfan J,
Zabolotnyy D,
Kienzer HR,
Cupissol D,
Peyrade F,
Benasso M,
Vynnychenko I,
De Raucourt D,
Bokemeyer C,
Schueler A,
Amellal N,
Hitt R</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2008 Sep 11;359(11):1116-27.
doi: 10.1056/NEJMoa0802656.
<span class="bold">PMID: </span><a href="/pubmed/18784101" target="_blank">18784101</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18486742">Head and neck cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Argiris A,
Karamouzis MV,
Raben D,
Ferris RL</span><br />
<span class="medgenPMjournal">Lancet</span>
2008 May 17;371(9625):1695-709.
doi: 10.1016/S0140-6736(08)60728-X.
<span class="bold">PMID: </span><a href="/pubmed/18486742" target="_blank">18486742</a><a href="/pmc/articles/PMC7720415" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Squamous%20cell%20carcinoma%20of%20the%20head%20and%20neck%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1925)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/35172587">Xevinapant or placebo plus chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck: TrilynX phase III study design.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bourhis J,
Burtness B,
Licitra LF,
Nutting C,
Schoenfeld JD,
Omar M,
Bouisset F,
Nauwelaerts H,
Urfer Y,
Zanna C,
Cohen EE</span><br />
<span class="medgenPMjournal">Future Oncol</span>
2022 May;18(14):1669-1678.
Epub 2022 Feb 17
doi: 10.2217/fon-2021-1634.
<span class="bold">PMID: </span><a href="/pubmed/35172587" target="_blank">35172587</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27247226">Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Seiwert TY,
Burtness B,
Mehra R,
Weiss J,
Berger R,
Eder JP,
Heath K,
McClanahan T,
Lunceford J,
Gause C,
Cheng JD,
Chow LQ</span><br />
<span class="medgenPMjournal">Lancet Oncol</span>
2016 Jul;17(7):956-965.
Epub 2016 May 27
doi: 10.1016/S1470-2045(16)30066-3.
<span class="bold">PMID: </span><a href="/pubmed/27247226" target="_blank">27247226</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19454430">Squamous cell carcinoma of the head and neck: ESMO clinical recommendations for diagnosis, treatment and follow-up.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Licitra L,
Felip E;
ESMO Guidelines Working Group</span><br />
<span class="medgenPMjournal">Ann Oncol</span>
2009 May;20 Suppl 4:121-2.
doi: 10.1093/annonc/mdp149.
<span class="bold">PMID: </span><a href="/pubmed/19454430" target="_blank">19454430</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18486742">Head and neck cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Argiris A,
Karamouzis MV,
Raben D,
Ferris RL</span><br />
<span class="medgenPMjournal">Lancet</span>
2008 May 17;371(9625):1695-709.
doi: 10.1016/S0140-6736(08)60728-X.
<span class="bold">PMID: </span><a href="/pubmed/18486742" target="_blank">18486742</a><a href="/pmc/articles/PMC7720415" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/12376245">Unknown primary squamous cell carcinoma of the head and neck: a review of diagnosis, treatment and outcomes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Adams JR,
O'Brien CJ</span><br />
<span class="medgenPMjournal">Asian J Surg</span>
2002 Apr;25(2):188-93.
doi: 10.1016/S1015-9584(09)60172-X.
<span class="bold">PMID: </span><a href="/pubmed/12376245" target="_blank">12376245</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Squamous%20cell%20carcinoma%20of%20the%20head%20and%20neck%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (954)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/36796234">Extended follow-up of a phase 2 trial of xevinapant plus chemoradiotherapy in high-risk locally advanced squamous cell carcinoma of the head and neck: a randomised clinical trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tao Y,
Sun XS,
Pointreau Y,
Le Tourneau C,
Sire C,
Kaminsky MC,
Coutte A,
Alfonsi M,
Calderon B,
Boisselier P,
Martin L,
Miroir J,
Ramee JF,
Delord JP,
Clatot F,
Rolland F,
Villa J,
Magne N,
Elicin O,
Gherga E,
Nguyen F,
Lafond C,
Bera G,
Calugaru V,
Geoffrois L,
Chauffert B,
Damstrup L,
Crompton P,
Ennaji A,
Gollmer K,
Nauwelaerts H,
Bourhis J</span><br />
<span class="medgenPMjournal">Eur J Cancer</span>
2023 Apr;183:24-37.
Epub 2023 Jan 9
doi: 10.1016/j.ejca.2022.12.015.
<span class="bold">PMID: </span><a href="/pubmed/36796234" target="_blank">36796234</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35172587">Xevinapant or placebo plus chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck: TrilynX phase III study design.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bourhis J,
Burtness B,
Licitra LF,
Nutting C,
Schoenfeld JD,
Omar M,
Bouisset F,
Nauwelaerts H,
Urfer Y,
Zanna C,
Cohen EE</span><br />
<span class="medgenPMjournal">Future Oncol</span>
2022 May;18(14):1669-1678.
Epub 2022 Feb 17
doi: 10.2217/fon-2021-1634.
<span class="bold">PMID: </span><a href="/pubmed/35172587" target="_blank">35172587</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27718784">Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ferris RL,
Blumenschein G Jr,
Fayette J,
Guigay J,
Colevas AD,
Licitra L,
Harrington K,
Kasper S,
Vokes EE,
Even C,
Worden F,
Saba NF,
Iglesias Docampo LC,
Haddad R,
Rordorf T,
Kiyota N,
Tahara M,
Monga M,
Lynch M,
Geese WJ,
Kopit J,
Shaw JW,
Gillison ML</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2016 Nov 10;375(19):1856-1867.
Epub 2016 Oct 8
doi: 10.1056/NEJMoa1602252.
<span class="bold">PMID: </span><a href="/pubmed/27718784" target="_blank">27718784</a><a href="/pmc/articles/PMC5564292" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18784101">Platinum-based chemotherapy plus cetuximab in head and neck cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Vermorken JB,
Mesia R,
Rivera F,
Remenar E,
Kawecki A,
Rottey S,
Erfan J,
Zabolotnyy D,
Kienzer HR,
Cupissol D,
Peyrade F,
Benasso M,
Vynnychenko I,
De Raucourt D,
Bokemeyer C,
Schueler A,
Amellal N,
Hitt R</span><br />
<span class="medgenPMjournal">N Engl J Med</span>
2008 Sep 11;359(11):1116-27.
doi: 10.1056/NEJMoa0802656.
<span class="bold">PMID: </span><a href="/pubmed/18784101" target="_blank">18784101</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18486742">Head and neck cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Argiris A,
Karamouzis MV,
Raben D,
Ferris RL</span><br />
<span class="medgenPMjournal">Lancet</span>
2008 May 17;371(9625):1695-709.
doi: 10.1016/S0140-6736(08)60728-X.
<span class="bold">PMID: </span><a href="/pubmed/18486742" target="_blank">18486742</a><a href="/pmc/articles/PMC7720415" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Squamous%20cell%20carcinoma%20of%20the%20head%20and%20neck%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1861)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/36796234">Extended follow-up of a phase 2 trial of xevinapant plus chemoradiotherapy in high-risk locally advanced squamous cell carcinoma of the head and neck: a randomised clinical trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tao Y,
Sun XS,
Pointreau Y,
Le Tourneau C,
Sire C,
Kaminsky MC,
Coutte A,
Alfonsi M,
Calderon B,
Boisselier P,
Martin L,
Miroir J,
Ramee JF,
Delord JP,
Clatot F,
Rolland F,
Villa J,
Magne N,
Elicin O,
Gherga E,
Nguyen F,
Lafond C,
Bera G,
Calugaru V,
Geoffrois L,
Chauffert B,
Damstrup L,
Crompton P,
Ennaji A,
Gollmer K,
Nauwelaerts H,
Bourhis J</span><br />
<span class="medgenPMjournal">Eur J Cancer</span>
2023 Apr;183:24-37.
Epub 2023 Jan 9
doi: 10.1016/j.ejca.2022.12.015.
<span class="bold">PMID: </span><a href="/pubmed/36796234" target="_blank">36796234</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30444304">Natural history of untreated squamous cell carcinoma of the head and neck.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Liu F,
Yuan S,
Fang Q,
Sun Q</span><br />
<span class="medgenPMjournal">Clin Otolaryngol</span>
2019 Mar;44(2):200-203.
Epub 2018 Dec 27
doi: 10.1111/coa.13260.
<span class="bold">PMID: </span><a href="/pubmed/30444304" target="_blank">30444304</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27247226">Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Seiwert TY,
Burtness B,
Mehra R,
Weiss J,
Berger R,
Eder JP,
Heath K,
McClanahan T,
Lunceford J,
Gause C,
Cheng JD,
Chow LQ</span><br />
<span class="medgenPMjournal">Lancet Oncol</span>
2016 Jul;17(7):956-965.
Epub 2016 May 27
doi: 10.1016/S1470-2045(16)30066-3.
<span class="bold">PMID: </span><a href="/pubmed/27247226" target="_blank">27247226</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19454430">Squamous cell carcinoma of the head and neck: ESMO clinical recommendations for diagnosis, treatment and follow-up.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Licitra L,
Felip E;
ESMO Guidelines Working Group</span><br />
<span class="medgenPMjournal">Ann Oncol</span>
2009 May;20 Suppl 4:121-2.
doi: 10.1093/annonc/mdp149.
<span class="bold">PMID: </span><a href="/pubmed/19454430" target="_blank">19454430</a></div>
<div class="nl"><a target="_blank" href="/pubmed/1458630">Cell kinetics in squamous cell carcinoma of the head and neck.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Stell PM</span><br />
<span class="medgenPMjournal">Clin Otolaryngol Allied Sci</span>
1992 Oct;17(5):444-8.
doi: 10.1111/j.1365-2273.1992.tb01691.x.
<span class="bold">PMID: </span><a href="/pubmed/1458630" target="_blank">1458630</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Squamous%20cell%20carcinoma%20of%20the%20head%20and%20neck%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1733)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/37536941">Nivolumab and ipilimumab in combination with radiotherapy in patients with high-risk locally advanced squamous cell carcinoma of the head and neck.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Johnson JM,
Vathiotis IA,
Harshyne LA,
Ali A,
Bar Ad V,
Axelrod R,
Lorber E,
Curry J,
Cognetti DM,
Luginbuhl AJ,
Tuluc M,
Keith S,
Mahoney MG,
Argiris A</span><br />
<span class="medgenPMjournal">J Immunother Cancer</span>
2023 Aug;11(8)
doi: 10.1136/jitc-2023-007141.
<span class="bold">PMID: </span><a href="/pubmed/37536941" target="_blank">37536941</a><a href="/pmc/articles/PMC10401226" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34855034">Photodynamic therapy for squamous cell carcinoma of the head and neck: narrative review focusing on photosensitizers.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ibarra AMC,
Cecatto RB,
Motta LJ,
Dos Santos Franco AL,
de Fátima Teixeira da Silva D,
Nunes FD,
Hamblin MR,
Rodrigues MFSD</span><br />
<span class="medgenPMjournal">Lasers Med Sci</span>
2022 Apr;37(3):1441-1470.
Epub 2021 Dec 2
doi: 10.1007/s10103-021-03462-3.
<span class="bold">PMID: </span><a href="/pubmed/34855034" target="_blank">34855034</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31307547">The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cohen EEW,
Bell RB,
Bifulco CB,
Burtness B,
Gillison ML,
Harrington KJ,
Le QT,
Lee NY,
Leidner R,
Lewis RL,
Licitra L,
Mehanna H,
Mell LK,
Raben A,
Sikora AG,
Uppaluri R,
Whitworth F,
Zandberg DP,
Ferris RL</span><br />
<span class="medgenPMjournal">J Immunother Cancer</span>
2019 Jul 15;7(1):184.
doi: 10.1186/s40425-019-0662-5.
<span class="bold">PMID: </span><a href="/pubmed/31307547" target="_blank">31307547</a><a href="/pmc/articles/PMC6632213" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27160335">Afatinib in squamous cell carcinoma of the head and neck.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Specenier P,
Vermorken J</span><br />
<span class="medgenPMjournal">Expert Opin Pharmacother</span>
2016 Jun;17(9):1295-301.
Epub 2016 May 19
doi: 10.1080/14656566.2016.1183647.
<span class="bold">PMID: </span><a href="/pubmed/27160335" target="_blank">27160335</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19828002">Cetuximab in metastatic or recurrent head and neck cancer: the EXTREME trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rivera F,
García-Castaño A,
Vega N,
Vega-Villegas ME,
Gutiérrez-Sanz L</span><br />
<span class="medgenPMjournal">Expert Rev Anticancer Ther</span>
2009 Oct;9(10):1421-8.
doi: 10.1586/era.09.113.
<span class="bold">PMID: </span><a href="/pubmed/19828002" target="_blank">19828002</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Squamous%20cell%20carcinoma%20of%20the%20head%20and%20neck%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1275)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/37329358">Functional and quality-of-life outcomes following salvage surgery for recurrent squamous cell carcinoma of the head and neck: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Williamson A,
Jashek-Ahmed F,
Hardman J,
Paleri V</span><br />
<span class="medgenPMjournal">Eur Arch Otorhinolaryngol</span>
2023 Oct;280(10):4597-4618.
Epub 2023 Jun 17
doi: 10.1007/s00405-023-08056-z.
<span class="bold">PMID: </span><a href="/pubmed/37329358" target="_blank">37329358</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36335818">The prognostic role of tumor associated macrophages in squamous cell carcinoma of the head and neck: A systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bisheshar SK,
van der Kamp MF,
de Ruiter EJ,
Ruiter LN,
van der Vegt B,
Breimer GE,
Willems SM</span><br />
<span class="medgenPMjournal">Oral Oncol</span>
2022 Dec;135:106227.
Epub 2022 Nov 3
doi: 10.1016/j.oraloncology.2022.106227.
<span class="bold">PMID: </span><a href="/pubmed/36335818" target="_blank">36335818</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35713173">Sentinel lymph node biopsy in high-risk cutaneous squamous cell carcinoma of the head and neck: Systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Costantino A,
Canali L,
Festa BM,
Spriano G,
Mercante G,
De Virgilio A</span><br />
<span class="medgenPMjournal">Head Neck</span>
2022 Oct;44(10):2288-2300.
Epub 2022 Jun 17
doi: 10.1002/hed.27121.
<span class="bold">PMID: </span><a href="/pubmed/35713173" target="_blank">35713173</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34729845">Salvage surgery for recurrent squamous cell carcinoma of the head and neck: Systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bulbul MG,
Genovese TJ,
Hagan K,
Rege S,
Qureshi A,
Varvares MA</span><br />
<span class="medgenPMjournal">Head Neck</span>
2022 Jan;44(1):275-285.
Epub 2021 Nov 3
doi: 10.1002/hed.26898.
<span class="bold">PMID: </span><a href="/pubmed/34729845" target="_blank">34729845</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32363116">The prognostic role of NK cells and their ligands in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bisheshar SK,
De Ruiter EJ,
Devriese LA,
Willems SM</span><br />
<span class="medgenPMjournal">Oncoimmunology</span>
2020;9(1):1747345.
Epub 2020 Apr 23
doi: 10.1080/2162402X.2020.1747345.
<span class="bold">PMID: </span><a href="/pubmed/32363116" target="_blank">32363116</a><a href="/pmc/articles/PMC7185215" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Squamous%20cell%20carcinoma%20of%20the%20head%20and%20neck%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (46)</a></div></div>
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<div class="supplemental col three_col last">
<h2 class="offscreen_noflow">Supplemental Content</h2>
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<!-- MedGen supplemental column starts here -->
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<div class="portlet mgSection" id="ID_113">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
</div>
<div class="portlet mgSection" id="ID_106">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C1168401%5bDISCUI%5d&amp;filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (41)</a></li>
<li><a href="/gtr/tests?term=C1168401%5bDISCUI%5d&amp;filter=method%3A3%5F24" target="_blank">FISH-metaphase (1)</a></li>
<li><a href="/gtr/tests?term=C1168401%5bDISCUI%5d&amp;filter=method%3A3%5F31" target="_blank">Fluorescence in situ hybridization (FISH) (1)</a></li>
<li><a href="/gtr/tests?term=C1168401%5bDISCUI%5d&amp;filter=method%3A2%5F17" target="_blank">Mutation scanning of the entire coding region (1)</a></li>
<li><a href="/gtr/tests?term=C1168401%5bDISCUI%5d&amp;filter=method%3A2%5F30" target="_blank">RNA analysis (3)</a></li>
<li><a href="/gtr/tests?term=C1168401%5bDISCUI%5d&amp;filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (5)</a></li>
<li><a href="/gtr/tests?term=C1168401%5bDISCUI%5d&amp;filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (48)</a></li>
<li><a href="/gtr/tests?term=C1168401%5bDISCUI%5d&amp;filter=method%3A2%5F19" target="_blank">Targeted variant analysis (6)</a></li>
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C1168401%5bDISCUI%5d" target="_blank">See all (63)</a></total></li>
</ul></div>
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