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<meta name="keywords" content="C0424375, bites self, biting self, finding, self-biting, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Habitual biting of one's own body." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Self-biting (Concept Id: C0424375)
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<!--
UID=603118
ConceptID=C0424375
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Self-biting</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>603118</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0424375</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Bites self; Biting self</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Biting self (248072009); Bites self (248072009)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0012169">HP:0012169</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Habitual biting of one's own body. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Self-biting</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/474891" ref="tree=MeSH" title="MedGen record for Congenital Systemic Disorder">Congenital Systemic Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/105425" ref="tree=MeSH" title="MedGen record for Abnormality of the nervous system">Abnormality of the nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/868417" ref="tree=MeSH" title="MedGen record for Abnormal nervous system physiology">Abnormal nervous system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/868938" ref="tree=MeSH" title="MedGen record for Abnormality of mental function">Abnormality of mental function</a></span><ul><li><span class="TLline"><a href="/medgen/14048" ref="tree=MeSH" title="MedGen record for Atypical behavior">Atypical behavior</a></span><ul><li><span class="TLline"><a href="/medgen/88371" ref="tree=MeSH" title="MedGen record for Self-injurious behavior">Self-injurious behavior</a></span><ul><li><span class="matched_ds">Self-biting</span><ul><li><span class="TLline"><a href="/medgen/1853236" ref="tree=MeSH" title="MedGen record for Autophagia">Autophagia</a></span></li><li><span class="TLline"><a href="/medgen/44581" ref="tree=MeSH" title="MedGen record for Nail-biting">Nail-biting</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_8912"><div><strong>Fragile X syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>8912</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0016667</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">FMR1 disorders include fragile X syndrome (FXS), fragile X-associated tremor/ataxia syndrome (FXTAS), and fragile X-associated primary ovarian insufficiency (FXPOI). Fragile X syndrome occurs in individuals with an FMR1 full mutation or other loss-of-function variant and is nearly always characterized in affected males by developmental delay and intellectual disability along with a variety of behavioral issues. Autism spectrum disorder is present in 50%-70% of individuals with FXS. Affected males may have characteristic craniofacial features (which become more obvious with age) and medical problems including hypotonia, gastroesophageal reflux, strabismus, seizures, sleep disorders, joint laxity, pes planus, scoliosis, and recurrent otitis media. Adults may have mitral valve prolapse or aortic root dilatation. The physical and behavioral features seen in males with FXS have been reported in females heterozygous for the FMR1 full mutation, but with lower frequency and milder involvement. FXTAS occurs in individuals who have an FMR1 premutation and is characterized by late-onset, progressive cerebellar ataxia and intention tremor followed by cognitive impairment. Psychiatric disorders are common. Age of onset is typically between 60 and 65 years and is more common among males who are hemizygous for the premutation (40%) than among females who are heterozygous for the premutation (16%-20%). FXPOI, defined as hypergonadotropic hypogonadism before age 40 years, has been observed in 20% of women who carry a premutation allele compared to 1% in the general population.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/8912">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_482290"><div><strong>Encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482290</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3280660</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Encephalopathy due to defective mitochondrial and peroxisomal fission-1 (EMPF1) is characterized by delayed psychomotor development and hypotonia that may lead to death in childhood. Many patients develop refractory seizures, consistent with an epileptic encephalopathy, and thereafter show neurologic decline. The age at onset, features, and severity are variable, and some patients may not have clinical evidence of mitochondrial or peroxisomal dysfunction (summary by Sheffer et al., 2016; Fahrner et al., 2016).&#13; Genetic Heterogeneity of Encephalopathy Due to Defective Mitochondrial And Peroxisomal Fission&#13; See also EMPF2 (617086), caused by mutation in the MFF gene (614785) on chromosome 2q36.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/482290">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_813060"><div><strong>X-linked intellectual disability, Cantagrel type</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>813060</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3806730</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">X-linked intellectual developmental disorder-98 (XLID98) is a neurodevelopmental disorder characterized by delayed psychomotor development, poor speech, behavioral abnormalities, poor overall growth, dysmorphic facial features, and often early-onset seizures. Some carrier females are unaffected, whereas other females with mutations are affected; males tend to be more severely affected than females. It is believed that the phenotypic variability and disease manifestations in female carriers results from skewed X-inactivation or cellular mosaicism (summary by de Lange et al., 2016).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/813060">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1675904"><div><strong>Hypomagnesemia, seizures, and intellectual disability 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1675904</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5193023</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Hypomagnesemia, seizures, and impaired intellectual development-2 (HOMGSMR2) is characterized by generalized seizures in infancy, severe hypomagnesemia, and renal magnesium wasting. Seizures persist despite magnesium supplementation and are associated with significantly impaired intellectual development (Schlingmann et al., 2018).&#13; For a discussion of genetic heterogeneity of hypomagnesemia, seizures, and impaired intellectual development, see HOMGSMR1 (616418).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1675904">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1808159"><div><strong>Intellectual developmental disorder, autosomal recessive 75, with neuropsychiatric features and variant lissencephaly</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1808159</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5676961</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Autosomal recessive intellectual developmental disorder-75 with neuropsychiatric features and variant lissencephaly (MRT75) is characterized by global developmental delay apparent from infancy or early childhood and moderate to profoundly impaired intellectual development. Most affected individuals have behavioral abnormalities, including aggression and ADHD; a few have psychiatric manifestations, including psychosis. More variable additional features include well-controlled seizures and dysmorphic facial features. Brain imaging often shows frontal predominant pachygyria or other gyri/sulci abnormalities, consistent with a variant of lissencephaly and a malformation of cortical development (MCD) (summary by Zaki et al., 2021).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1808159">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1823966"><div><strong>Intellectual developmental disorder, autosomal recessive 77</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1823966</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5774193</a></dd><dt><span class="dotprefix"></span></dt><dd>Mental or Behavioral Dysfunction</dd></dl></div></div></div>
<div class="spaceAbove">Autosomal recessive intellectual developmental disorder-77 (MRT77) is a nonsyndromic neurodevelopmental disorder characterized by global developmental delay with variably impaired cognitive development apparent from infancy. Affected individuals usually have delayed walking, sometimes with an unsteady gait, and may have poor speech and communication. Brain imaging is normal, and there are no additional significant neurologic abnormalities (Khoshbakht et al., 2021).&#13; Mutation in the CEP104 gene also causes a form of Joubert syndrome (JBTS25; 616781).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1823966">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1854654"><div><strong>Neurodevelopmental disorder with hypotonia, brain anomalies, distinctive facies, and absent language</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1854654</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5935628</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">ReNU syndrome (RENU), also known as neurodevelopmental disorder with hypotonia, brain anomalies, distinctive facies, and absent language (NEDHAFA), is characterized by hypotonia, global developmental delay, severely impaired intellectual development with poor or absent speech, delayed walking or inability to walk, feeding difficulties with poor overall growth, seizures (in most), dysmorphic facial features, and brain anomalies, including ventriculomegaly, thin corpus callosum, and progressive white matter loss (Greene et al., 2024; Schot et al., 2024; Chen et al., 2024).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1854654">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482290" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_8912" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Fragile X syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1675904" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypomagnesemia, seizures, and intellectual disability 2</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1808159" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Intellectual developmental disorder, autosomal recessive 75, with neuropsychiatric features and variant lissencephaly</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1823966" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Intellectual developmental disorder, autosomal recessive 77</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1854654" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurodevelopmental disorder with hypotonia, brain anomalies, distinctive facies, and absent language</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_813060" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">X-linked intellectual disability, Cantagrel type</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/34891105">Safety and Efficacy of Botulinum Toxin in the Treatment of Self-Biting Behavior in Lesch-Nyhan Disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Garcia-Romero MDM,
Torres RJ,
Garcia-Puig J,
Pascual-Pascual SI</span><br />
<span class="medgenPMjournal">Pediatr Neurol</span>
2022 Feb;127:6-10.
Epub 2021 Nov 1
doi: 10.1016/j.pediatrneurol.2021.10.018.
<span class="bold">PMID: </span><a href="/pubmed/34891105" target="_blank">34891105</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22self-biting%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/35723725">Self-biting behavior in patients with neonatal brachial plexus palsy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Heise CO,
Zaccariotto M,
Martins RS,
Sterman-Neto H,
Siqueira MG</span><br />
<span class="medgenPMjournal">Childs Nerv Syst</span>
2022 Sep;38(9):1773-1776.
Epub 2022 Jun 20
doi: 10.1007/s00381-022-05574-9.
<span class="bold">PMID: </span><a href="/pubmed/35723725" target="_blank">35723725</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33045542">The evolution of self-injurious behaviors in people with intellectual disability and epilepsy: A follow-up study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Buono S,
Zagaria T,
Recupero M,
Elia M,
Kerr M,
Di Nuovo S,
Ferri R</span><br />
<span class="medgenPMjournal">Seizure</span>
2020 Nov;82:99-104.
Epub 2020 Sep 16
doi: 10.1016/j.seizure.2020.09.009.
<span class="bold">PMID: </span><a href="/pubmed/33045542" target="_blank">33045542</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28653211">Functional (psychogenic) stereotypies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Baizabal-Carvallo JF,
Jankovic J</span><br />
<span class="medgenPMjournal">J Neurol</span>
2017 Jul;264(7):1482-1487.
Epub 2017 Jun 26
doi: 10.1007/s00415-017-8551-7.
<span class="bold">PMID: </span><a href="/pubmed/28653211" target="_blank">28653211</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9433793">Relax and try this instead: abbreviated habit reversal for maladaptive self-biting.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jones KM,
Swearer SM,
Friman PC</span><br />
<span class="medgenPMjournal">J Appl Behav Anal</span>
1997 Winter;30(4):697-9.
doi: 10.1901/jaba.1997.30-697.
<span class="bold">PMID: </span><a href="/pubmed/9433793" target="_blank">9433793</a><a href="/pmc/articles/PMC1284085" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/6470161">Contingent application of a protective device to treat the severe self-biting behavior of a disturbed autistic child.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Neufeld A,
Fantuzzo JW</span><br />
<span class="medgenPMjournal">J Behav Ther Exp Psychiatry</span>
1984 Mar;15(1):79-83.
doi: 10.1016/0005-7916(84)90127-7.
<span class="bold">PMID: </span><a href="/pubmed/6470161" target="_blank">6470161</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Self-biting%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (14)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/29734991">Violent Parasomnia With Recurrent Biting and Surgical Interventions: Case Report and Differential Diagnosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Danish N,
Khawaja IS,
Schenck CH</span><br />
<span class="medgenPMjournal">J Clin Sleep Med</span>
2018 May 15;14(5):889-891.
doi: 10.5664/jcsm.7134.
<span class="bold">PMID: </span><a href="/pubmed/29734991" target="_blank">29734991</a><a href="/pmc/articles/PMC5940443" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29617065">Relationships Between Self-Injurious Behaviors, Pain Reactivity, and β-Endorphin in Children and Adolescents With Autism.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tordjman S,
Anderson GM,
Charrier A,
Oriol C,
Kermarrec S,
Canitano R,
Botbol M,
Coulon N,
Antoine C,
Brailly-Tabard S,
Cohen D,
Haidar H,
Trabado S,
Carlier M,
Bronsard G,
Mottron L</span><br />
<span class="medgenPMjournal">J Clin Psychiatry</span>
2018 Mar/Apr;79(2)
doi: 10.4088/JCP.16m10889.
<span class="bold">PMID: </span><a href="/pubmed/29617065" target="_blank">29617065</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28653211">Functional (psychogenic) stereotypies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Baizabal-Carvallo JF,
Jankovic J</span><br />
<span class="medgenPMjournal">J Neurol</span>
2017 Jul;264(7):1482-1487.
Epub 2017 Jun 26
doi: 10.1007/s00415-017-8551-7.
<span class="bold">PMID: </span><a href="/pubmed/28653211" target="_blank">28653211</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9612442">The coming of age of self-mutilation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Favazza AR</span><br />
<span class="medgenPMjournal">J Nerv Ment Dis</span>
1998 May;186(5):259-68.
doi: 10.1097/00005053-199805000-00001.
<span class="bold">PMID: </span><a href="/pubmed/9612442" target="_blank">9612442</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9122322">Clinical assessment of self-injurious behavior.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Brasic JR,
Barnett JY,
Ahn SC,
Nadrich RH,
Will MV,
Clair A</span><br />
<span class="medgenPMjournal">Psychol Rep</span>
1997 Feb;80(1):155-60.
doi: 10.2466/pr0.1997.80.1.155.
<span class="bold">PMID: </span><a href="/pubmed/9122322" target="_blank">9122322</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Self-biting%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (12)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/34891105">Safety and Efficacy of Botulinum Toxin in the Treatment of Self-Biting Behavior in Lesch-Nyhan Disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Garcia-Romero MDM,
Torres RJ,
Garcia-Puig J,
Pascual-Pascual SI</span><br />
<span class="medgenPMjournal">Pediatr Neurol</span>
2022 Feb;127:6-10.
Epub 2021 Nov 1
doi: 10.1016/j.pediatrneurol.2021.10.018.
<span class="bold">PMID: </span><a href="/pubmed/34891105" target="_blank">34891105</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29734991">Violent Parasomnia With Recurrent Biting and Surgical Interventions: Case Report and Differential Diagnosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Danish N,
Khawaja IS,
Schenck CH</span><br />
<span class="medgenPMjournal">J Clin Sleep Med</span>
2018 May 15;14(5):889-891.
doi: 10.5664/jcsm.7134.
<span class="bold">PMID: </span><a href="/pubmed/29734991" target="_blank">29734991</a><a href="/pmc/articles/PMC5940443" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9612442">The coming of age of self-mutilation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Favazza AR</span><br />
<span class="medgenPMjournal">J Nerv Ment Dis</span>
1998 May;186(5):259-68.
doi: 10.1097/00005053-199805000-00001.
<span class="bold">PMID: </span><a href="/pubmed/9612442" target="_blank">9612442</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9433793">Relax and try this instead: abbreviated habit reversal for maladaptive self-biting.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jones KM,
Swearer SM,
Friman PC</span><br />
<span class="medgenPMjournal">J Appl Behav Anal</span>
1997 Winter;30(4):697-9.
doi: 10.1901/jaba.1997.30-697.
<span class="bold">PMID: </span><a href="/pubmed/9433793" target="_blank">9433793</a><a href="/pmc/articles/PMC1284085" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/6891061">Self-injurious behavior produced in rats by daily caffeine and continuous amphetamine.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mueller K,
Saboda S,
Palmour R,
Nyhan WL</span><br />
<span class="medgenPMjournal">Pharmacol Biochem Behav</span>
1982 Oct;17(4):613-7.
doi: 10.1016/0091-3057(82)90332-x.
<span class="bold">PMID: </span><a href="/pubmed/6891061" target="_blank">6891061</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Self-biting%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (9)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/33045542">The evolution of self-injurious behaviors in people with intellectual disability and epilepsy: A follow-up study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Buono S,
Zagaria T,
Recupero M,
Elia M,
Kerr M,
Di Nuovo S,
Ferri R</span><br />
<span class="medgenPMjournal">Seizure</span>
2020 Nov;82:99-104.
Epub 2020 Sep 16
doi: 10.1016/j.seizure.2020.09.009.
<span class="bold">PMID: </span><a href="/pubmed/33045542" target="_blank">33045542</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21078074">Effective treatment of self-injurious oral trauma in Lesch-Nyhan syndrome: a case report.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Arhakis A,
Topouzelis N,
Kotsiomiti E,
Kotsanos N</span><br />
<span class="medgenPMjournal">Dent Traumatol</span>
2010 Dec;26(6):496-500.
doi: 10.1111/j.1600-9657.2010.00930.x.
<span class="bold">PMID: </span><a href="/pubmed/21078074" target="_blank">21078074</a></div>
<div class="nl"><a target="_blank" href="/pubmed/17284140">Self-injurious behavior in a community sample of young women: relationship with childhood abuse and other types of self-damaging behaviors.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Favaro A,
Ferrara S,
Santonastaso P</span><br />
<span class="medgenPMjournal">J Clin Psychiatry</span>
2007 Jan;68(1):122-31.
doi: 10.4088/jcp.v68n0117.
<span class="bold">PMID: </span><a href="/pubmed/17284140" target="_blank">17284140</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Self-biting%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/33045542">The evolution of self-injurious behaviors in people with intellectual disability and epilepsy: A follow-up study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Buono S,
Zagaria T,
Recupero M,
Elia M,
Kerr M,
Di Nuovo S,
Ferri R</span><br />
<span class="medgenPMjournal">Seizure</span>
2020 Nov;82:99-104.
Epub 2020 Sep 16
doi: 10.1016/j.seizure.2020.09.009.
<span class="bold">PMID: </span><a href="/pubmed/33045542" target="_blank">33045542</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30503152">Satisfaction of patients with amyotrophic lateral sclerosis with an oral appliance for managing oral self-biting injuries and alterations in their masticatory system: A case-series study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Riera-Punet N,
Martinez-Gomis J,
Zamora-Olave C,
Willaert E,
Peraire M</span><br />
<span class="medgenPMjournal">J Prosthet Dent</span>
2019 Apr;121(4):631-636.
Epub 2018 Nov 30
doi: 10.1016/j.prosdent.2018.06.010.
<span class="bold">PMID: </span><a href="/pubmed/30503152" target="_blank">30503152</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29617065">Relationships Between Self-Injurious Behaviors, Pain Reactivity, and β-Endorphin in Children and Adolescents With Autism.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tordjman S,
Anderson GM,
Charrier A,
Oriol C,
Kermarrec S,
Canitano R,
Botbol M,
Coulon N,
Antoine C,
Brailly-Tabard S,
Cohen D,
Haidar H,
Trabado S,
Carlier M,
Bronsard G,
Mottron L</span><br />
<span class="medgenPMjournal">J Clin Psychiatry</span>
2018 Mar/Apr;79(2)
doi: 10.4088/JCP.16m10889.
<span class="bold">PMID: </span><a href="/pubmed/29617065" target="_blank">29617065</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28653211">Functional (psychogenic) stereotypies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Baizabal-Carvallo JF,
Jankovic J</span><br />
<span class="medgenPMjournal">J Neurol</span>
2017 Jul;264(7):1482-1487.
Epub 2017 Jun 26
doi: 10.1007/s00415-017-8551-7.
<span class="bold">PMID: </span><a href="/pubmed/28653211" target="_blank">28653211</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22244737">Self-injury in people with intellectual disability and epilepsy: a matched controlled study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Buono S,
Scannella F,
Palmigiano MB,
Elia M,
Kerr M,
Di Nuovo S</span><br />
<span class="medgenPMjournal">Seizure</span>
2012 Apr;21(3):160-4.
Epub 2012 Jan 13
doi: 10.1016/j.seizure.2011.10.008.
<span class="bold">PMID: </span><a href="/pubmed/22244737" target="_blank">22244737</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Self-biting%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (18)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet mgSection" id="ID_113">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Self-biting" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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