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<!--
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||
UID=83428
|
||
ConceptID=C0346629
|
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-->
|
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Colorectal cancer</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>83428</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0346629</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Colorectal cancer, somatic; Malignant Colorectal Neoplasm</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Cancer of large intestine (363510005); Cancer of large bowel (363510005); CA - Cancer of large bowel (363510005); Malignant tumor of large intestine (363510005)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Genes (locations):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="AKT1 - ID: 207 - NCBI Gene" href="/gene/207" class="medgenPMinfo">AKT1</a> (14q32.33); <a target="_blank" title="APC - ID: 324 - NCBI Gene" href="/gene/324" class="medgenPMinfo">APC</a> (5q22.2); <a target="_blank" title="AURKA - ID: 6790 - NCBI Gene" href="/gene/6790" class="medgenPMinfo">AURKA</a> (20q13.2); <a target="_blank" title="AXIN2 - ID: 8313 - NCBI Gene" href="/gene/8313" class="medgenPMinfo">AXIN2</a> (17q24.1); <a target="_blank" title="BAX - ID: 581 - NCBI Gene" href="/gene/581" class="medgenPMinfo">BAX</a> (19q13.33); <a target="_blank" title="BRAF - ID: 673 - NCBI Gene" href="/gene/673" class="medgenPMinfo">BRAF</a> (7q34); <a target="_blank" title="BUB1 - ID: 699 - NCBI Gene" href="/gene/699" class="medgenPMinfo">BUB1</a> (2q13); <a target="_blank" title="BUB1B - ID: 701 - NCBI Gene" href="/gene/701" class="medgenPMinfo">BUB1B</a> (15q15.1); <a target="_blank" title="CCND1 - ID: 595 - NCBI Gene" href="/gene/595" class="medgenPMinfo">CCND1</a> (11q13.3); <a target="_blank" title="CTNNB1 - ID: 1499 - NCBI Gene" href="/gene/1499" class="medgenPMinfo">CTNNB1</a> (3p22.1); <a target="_blank" title="DCC - ID: 1630 - NCBI Gene" href="/gene/1630" class="medgenPMinfo">DCC</a> (18q21.2); <a target="_blank" title="DLC1 - ID: 10395 - NCBI Gene" href="/gene/10395" class="medgenPMinfo">DLC1</a> (8p22); <a target="_blank" title="EP300 - ID: 2033 - NCBI Gene" href="/gene/2033" class="medgenPMinfo">EP300</a> (22q13.2); <a target="_blank" title="FGFR3 - ID: 2261 - NCBI Gene" href="/gene/2261" class="medgenPMinfo">FGFR3</a> (4p16.3); <a target="_blank" title="FLCN - ID: 201163 - NCBI Gene" href="/gene/201163" class="medgenPMinfo">FLCN</a> (17p11.2); <a target="_blank" title="MCC - ID: 4163 - NCBI Gene" href="/gene/4163" class="medgenPMinfo">MCC</a> (5q22.2); <a target="_blank" title="MLH3 - ID: 27030 - NCBI Gene" href="/gene/27030" class="medgenPMinfo">MLH3</a> (14q24.3); <a target="_blank" title="NRAS - ID: 4893 - NCBI Gene" href="/gene/4893" class="medgenPMinfo">NRAS</a> (1p13.2); <a target="_blank" title="PDGFRL - ID: 5157 - NCBI Gene" href="/gene/5157" class="medgenPMinfo">PDGFRL</a> (8p22); <a target="_blank" title="PIK3CA - ID: 5290 - NCBI Gene" href="/gene/5290" class="medgenPMinfo">PIK3CA</a> (3q26.32); <a target="_blank" title="PLA2G2A - ID: 5320 - NCBI Gene" href="/gene/5320" class="medgenPMinfo">PLA2G2A</a> (1p36.13); <a target="_blank" title="PTPN12 - ID: 5782 - NCBI Gene" href="/gene/5782" class="medgenPMinfo">PTPN12</a> (7q11.23); <a target="_blank" title="PTPRJ - ID: 5795 - NCBI Gene" href="/gene/5795" class="medgenPMinfo">PTPRJ</a> (11p11.2); <a target="_blank" title="RAD54B - ID: 25788 - NCBI Gene" href="/gene/25788" class="medgenPMinfo">RAD54B</a> (8q22.1); <a target="_blank" title="SRC - ID: 6714 - NCBI Gene" href="/gene/6714" class="medgenPMinfo">SRC</a> (20q11.23); <a target="_blank" title="TLR2 - ID: 7097 - NCBI Gene" href="/gene/7097" class="medgenPMinfo">TLR2</a> (4q31.3); <a target="_blank" title="TP53 - ID: 7157 - NCBI Gene" href="/gene/7157" class="medgenPMinfo">TP53</a> (17p13.1)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0005575" target="_blank">MONDO:0005575</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/114500" target="_blank">114500</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=466667">ORPHA466667</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_101">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Disease_characteristics">Disease characteristics</h1><a sid="101" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="excerpt">Excerpted from the <i>GeneReview: </i><a href="/books/NBK1211" target="_blank">Lynch Syndrome</a></div><div>Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome. [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div><div class="spaceAbove"><strong>Full text of <i>GeneReview</i> (by section):</strong><br /><a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Summary" target="NBK1211">Summary</a> | <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Diagnosis" target="NBK1211">Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Clinical_Characteristics" target="NBK1211">Clinical Characteristics</a> | <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Genetically_Related_Allelic_Disord" target="NBK1211">Genetically Related (Allelic) Disorders</a> | <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Differential_Diagnosis" target="NBK1211">Differential Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Management" target="NBK1211">Management</a> | <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Genetic_Counseling" target="NBK1211">Genetic Counseling</a> | <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Resources" target="NBK1211">Resources</a> | <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Molecular_Genetics" target="NBK1211">Molecular Genetics</a> | <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.Chapter_Notes" target="NBK1211">Chapter Notes</a> | <a class="medgenPMinfo" href="/books/NBK1211#hnpcc.References" target="NBK1211">References</a></div><div class="spaceAbove"><strong>Authors:</strong><br />
|
||
Gregory Idos | Laura Valle <a href="/books/NBK1211" target="NBK1211" title="NCBI Bookshelf: Lynch Syndrome">view full author information</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_117">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_description">Additional description</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From OMIM</strong><br />Colorectal cancer is a heterogeneous disease that is common in both men and women. In addition to lifestyle and environmental risk factors, gene defects can contribute to an inherited predisposition to CRC. CRC is caused by changes in different molecular pathogenic pathways, such as chromosomal instability, CpG island methylator phenotype, and microsatellite instability. Chromosome instability is the most common alteration and is present in almost 85% of all cases (review by Schweiger et al., 2013).
|
||
Genetic Heterogeneity of Colorectal Cancer
|
||
Mutations in a single gene result in a marked predisposition to colorectal cancer in familial adenomatous polyposis (FAP; 175100) and hereditary nonpolyposis colorectal cancer (HNPCC; see 120435). FAP is caused by mutations in the APC gene (611731), whereas HNPCC is caused by mutations in several genes, including MSH2 (609309), MLH1 (120436), PMS1 (600258), PMS2 (600259), MSH6 (600678), TGFBR2 (190182), and MLH3 (604395). Epigenetic silencing of MSH2 results in a form of HNPCC (see HNPCC8, 613244). Other colorectal cancer syndromes include autosomal recessive adenomatous polyposis (608456), which is caused by mutations in the MUTYH gene (604933), and oligodontia-colorectal cancer syndrome (608615), which is caused by mutations in the AXIN2 gene (604025). Colorectal cancer is a predominant form of cancer in tumor predisposition syndrome-4 (TPDS4; 609265), which is caused by mutation in the CHEK2 gene (604373). A germline mutation in the PLA2G2A gene (172411) was identified in a patient with colorectal cancer.
|
||
Germline susceptibility loci for colorectal cancer have also been identified. CRCS1 (608812) is conferred by mutation in the GALNT12 gene (610290) on chromosome 9q22; CRCS2 (611469) maps to chromosome 8q24; CRCS3 (612229) is conferred by variation in the SMAD7 gene (602932) on chromosome 18; CRCS4 (601228) is conferred by variation on 15q that causes increased and ectopic expression of the GREM1 gene (603054); CRCS5 (612230) maps to chromosome 10p14; CRCS6 (612231) maps to chromosome 8q23; CRCS7 (612232) maps to chromosome 11q23; CRCS8 (612589) maps to chromosome 14q22; CRCS9 (612590) maps to 16q22; CRCS10 (612591) is conferred by mutation in the POLD1 gene (174761) on chromosome 19q13; CRCS11 (612592) maps to chromosome 20p12; and CRCS12 (615083) is conferred by mutation in the POLE gene (174762) on chromosome 12q24.
|
||
Somatic mutations in many different genes, including KRAS (190070), PIK3CA (171834), BRAF (164757), CTNNB1 (116806), FGFR3 (134934), AXIN2 (604025), AKT1 (164730), MCC (159350), MYH11 (160745), PARK2 (602544), RNF43 (612482), and BUB1 (601452), have been identified in colorectal cancer. <a target="_blank" href="http://www.omim.org/entry/114500">http://www.omim.org/entry/114500</a></div></div>
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||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_102">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
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||
<div class="divPopper rprt" id="clin_766"><div><strong>Renal cell carcinoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0007134</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A type of carcinoma of the kidney with origin in the epithelium of the proximal convoluted renal tubule.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766">Feature record</a> | <a href="/medgen?term=%22Renal%20cell%20carcinoma%22%5BClinical%20Features%5D%20OR%20766%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_76013"><div><strong>Transitional cell carcinoma of the bladder</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>76013</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0279680</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The presence of a carcinoma of the urinary bladder with origin in a transitional epithelial cell.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/76013">Feature record</a> | <a href="/medgen?term=%22Transitional%20cell%20carcinoma%20of%20the%20bladder%22%5BClinical%20Features%5D%20OR%2076013%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_83679"><div><strong>Uterine leiomyosarcoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>83679</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0280631</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The presence of a leiomyosarcoma of the uterus.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/83679">Feature record</a> | <a href="/medgen?term=%22Uterine%20leiomyosarcoma%22%5BClinical%20Features%5D%20OR%2083679%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_20958"><div><strong>Neoplasm of stomach</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>20958</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0038356</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A tumor (abnormal growth of tissue) of the stomach.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/20958">Feature record</a> | <a href="/medgen?term=%22Neoplasm%20of%20stomach%22%5BClinical%20Features%5D%20OR%2020958%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_870541"><div><strong>Hereditary nonpolyposis colorectal carcinoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>870541</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4024989</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/870541">Feature record</a> | <a href="/medgen?term=%22Hereditary%20nonpolyposis%20colorectal%20carcinoma%22%5BClinical%20Features%5D%20OR%20870541%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of the digestive system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_870541" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hereditary nonpolyposis colorectal carcinoma</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_20958" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neoplasm of stomach</a></span></li></ul></li><li><span class="TLline">Neoplasm</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_766" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Renal cell carcinoma</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_76013" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Transitional cell carcinoma of the bladder</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_83679" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Uterine leiomyosarcoma</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0009404[DISCUI]&test_type=Clinical" ref="ncbi_uid=3171">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=3171" ref="ncbi_uid=3171">V</a></span></span><span class="TLline"><a href="/medgen/3171" ref="tree=GTR&ncbi_uid=3171&link_uid=3171" title="View MedGen record for 'Neoplasm of the large intestine'">Neoplasm of the large intestine</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/91125" ref="tree=GTR&ncbi_uid=91125&link_uid=91125" title="View MedGen record for 'Benign neoplasm of large intestine'">Benign neoplasm of large intestine</a></span></li><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0346629[DISCUI]&test_type=Clinical" ref="ncbi_uid=83428">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1211/" ref="ncbi_uid=83428">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=83428" ref="ncbi_uid=83428">V</a></span></span><span class="TLline">Colorectal cancer</span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0007102[DISCUI]&test_type=Clinical" ref="ncbi_uid=2839">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=2839" target="_blank" href="/omim/114500">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=2839" ref="ncbi_uid=2839">V</a></span></span><span class="TLline"><a href="/medgen/2839" ref="tree=GTR&ncbi_uid=2839&link_uid=2839" title="View MedGen record for 'Colon cancer'">Colon cancer</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0699790[DISCUI]&test_type=Clinical" ref="ncbi_uid=147065">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=C0699790[DISCUI]&test_type=Research" ref="ncbi_uid=147065">R</a></span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1211/" ref="ncbi_uid=147065">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=147065" ref="ncbi_uid=147065">V</a></span></span><span class="TLline"><a href="/medgen/147065" ref="tree=GTR&ncbi_uid=147065&link_uid=147065" title="View MedGen record for 'Carcinoma of colon'">Carcinoma of colon</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/101033" ref="tree=GTR&ncbi_uid=101033&link_uid=101033" title="View MedGen record for 'Colon lymphoma'">Colon lymphoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/272493" ref="tree=GTR&ncbi_uid=272493&link_uid=272493" title="View MedGen record for 'Colon sarcoma'">Colon sarcoma</a></span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0009402[DISCUI]&test_type=Clinical" ref="ncbi_uid=3170">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=3170" target="_blank" href="/omim/114500">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=3170" ref="ncbi_uid=3170">V</a></span></span><span class="TLline"><a href="/medgen/3170" ref="tree=GTR&ncbi_uid=3170&link_uid=3170" title="View MedGen record for 'Colorectal carcinoma'">Colorectal carcinoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/474455" ref="tree=GTR&ncbi_uid=474455&link_uid=474455" title="View MedGen record for 'Colorectal lymphoma'">Colorectal lymphoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=CN280943[DISCUI]&test_type=Clinical" ref="ncbi_uid=965772">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=CN280943[DISCUI]&test_type=Research&redirect=true" ref="ncbi_uid=965772">R</a></span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=965772" ref="ncbi_uid=965772">V</a></span></span><span class="TLline"><a href="/medgen/965772" ref="tree=GTR&ncbi_uid=965772&link_uid=965772" title="View MedGen record for 'Familial colorectal cancer'">Familial colorectal cancer</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0949022[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=181763">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/181763" ref="tree=GTR&ncbi_uid=181763&link_uid=181763" title="View MedGen record for 'Malignant tumor of rectum'">Malignant tumor of rectum</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0007113[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=40100">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/40100" ref="tree=GTR&ncbi_uid=40100&link_uid=40100" title="View MedGen record for 'Rectal carcinoma'">Rectal carcinoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/233393" ref="tree=GTR&ncbi_uid=233393&link_uid=233393" title="View MedGen record for 'Rectum lymphoma'">Rectum lymphoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/277577" ref="tree=GTR&ncbi_uid=277577&link_uid=277577" title="View MedGen record for 'Rectum sarcoma'">Rectum sarcoma</a></span></li></ul></li></ul></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/8970" ref="tree=MeSH" title="MedGen record for Disorder of gastrointestinal tract">Disorder of gastrointestinal tract</a></span><ul><li><span class="TLline"><a href="/medgen/7130" ref="tree=MeSH" title="MedGen record for Intestinal disorder">Intestinal disorder</a></span><ul><li><span class="TLline"><a href="/medgen/43932" ref="tree=MeSH" title="MedGen record for Intestinal neoplasm">Intestinal neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/87562" ref="tree=MeSH" title="MedGen record for Intestinal cancer">Intestinal cancer</a></span><ul><li><span class="matched_ds">Colorectal cancer</span><ul><li><span class="TLline"><a href="/medgen/2839" ref="tree=MeSH" title="MedGen record for Colon cancer">Colon cancer</a></span><ul><li><span class="TLline"><a href="/medgen/147065" ref="tree=MeSH" title="MedGen record for Carcinoma of colon">Carcinoma of colon</a></span><ul><li><span class="TLline"><a href="/medgen/232083" ref="tree=MeSH" title="MedGen record for Adenosquamous colon carcinoma">Adenosquamous colon carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/101762" ref="tree=MeSH" title="MedGen record for Cecum carcinoma">Cecum carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/137834" ref="tree=MeSH" title="MedGen record for Colon adenocarcinoma">Colon adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/455933" ref="tree=MeSH" title="MedGen record for Colon Cancer by AJCC v6 Stage">Colon Cancer by AJCC v6 Stage</a></span></li><li><span class="TLline"><a href="/medgen/456315" ref="tree=MeSH" title="MedGen record for Colon Cancer by AJCC v7 Stage">Colon Cancer by AJCC v7 Stage</a></span></li><li><span class="TLline"><a href="/medgen/1619899" ref="tree=MeSH" title="MedGen record for Colon Cancer by AJCC v8 Stage">Colon Cancer by AJCC v8 Stage</a></span></li><li><span class="TLline"><a href="/medgen/1730673" ref="tree=MeSH" title="MedGen record for Colon Large Cell Neuroendocrine Carcinoma">Colon Large Cell Neuroendocrine Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/232087" ref="tree=MeSH" title="MedGen record for Colon small cell neuroendocrine carcinoma">Colon small cell neuroendocrine carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/76008" ref="tree=MeSH" title="MedGen record for Colon Undifferentiated Carcinoma">Colon Undifferentiated Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1717725" ref="tree=MeSH" title="MedGen record for Hereditary Colon Carcinoma">Hereditary Colon Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1649079" ref="tree=MeSH" title="MedGen record for Metastatic Colon Carcinoma">Metastatic Colon Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1791055" ref="tree=MeSH" title="MedGen record for Microsatellite Stable Colon Carcinoma">Microsatellite Stable Colon Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/82939" ref="tree=MeSH" title="MedGen record for Recurrent Colon Carcinoma">Recurrent Colon Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1663185" ref="tree=MeSH" title="MedGen record for Refractory Colon Carcinoma">Refractory Colon Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1710884" ref="tree=MeSH" title="MedGen record for Resectable Colon Carcinoma">Resectable Colon Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/155572" ref="tree=MeSH" title="MedGen record for Sigmoid Colon Carcinoma">Sigmoid Colon Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/272494" ref="tree=MeSH" title="MedGen record for Squamous cell carcinoma of colon">Squamous cell carcinoma of colon</a></span></li><li><span class="TLline"><a href="/medgen/1792785" ref="tree=MeSH" title="MedGen record for Unresectable Colon Carcinoma">Unresectable Colon Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/57557" ref="tree=MeSH" title="MedGen record for Cecum cancer">Cecum cancer</a></span><ul><li><span class="TLline"><a href="/medgen/232035" ref="tree=MeSH" title="MedGen record for Cecum lymphoma">Cecum lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/101033" ref="tree=MeSH" title="MedGen record for Colon lymphoma">Colon lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/232377" ref="tree=MeSH" title="MedGen record for Colon Hodgkin Lymphoma">Colon Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/155459" ref="tree=MeSH" title="MedGen record for Colon Non-Hodgkin Lymphoma">Colon Non-Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/272493" ref="tree=MeSH" title="MedGen record for Colon sarcoma">Colon sarcoma</a></span><ul><li><span class="TLline"><a href="/medgen/232378" ref="tree=MeSH" title="MedGen record for Colon Kaposi sarcoma">Colon Kaposi sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/232380" ref="tree=MeSH" title="MedGen record for Colon leiomyosarcoma">Colon leiomyosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/1649670" ref="tree=MeSH" title="MedGen record for Colon Liposarcoma">Colon Liposarcoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/83432" ref="tree=MeSH" title="MedGen record for Metastatic malignant neoplasm in the colon">Metastatic malignant neoplasm in the colon</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/3170" ref="tree=MeSH" title="MedGen record for Colorectal carcinoma">Colorectal carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/230816" ref="tree=MeSH" title="MedGen record for Adenocarcinoma of the large intestine">Adenocarcinoma of the large intestine</a></span><ul><li><span class="TLline"><a href="/medgen/233977" ref="tree=MeSH" title="MedGen record for Anal canal adenocarcinoma">Anal canal adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1724785" ref="tree=MeSH" title="MedGen record for Colorectal Adenoma-Like Adenocarcinoma">Colorectal Adenoma-Like Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/474445" ref="tree=MeSH" title="MedGen record for Colorectal Cribriform Comedo-Type Adenocarcinoma">Colorectal Cribriform Comedo-Type Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/317525" ref="tree=MeSH" title="MedGen record for Colorectal medullary carcinoma">Colorectal medullary carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/474448" ref="tree=MeSH" title="MedGen record for Colorectal Micropapillary Adenocarcinoma">Colorectal Micropapillary Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/317526" ref="tree=MeSH" title="MedGen record for Colorectal Mucinous Adenocarcinoma">Colorectal Mucinous Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1723389" ref="tree=MeSH" title="MedGen record for Colorectal Poorly Cohesive Adenocarcinoma">Colorectal Poorly Cohesive Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/474442" ref="tree=MeSH" title="MedGen record for Colorectal serrated adenocarcinoma">Colorectal serrated adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/272682" ref="tree=MeSH" title="MedGen record for Grade 1 Colorectal Adenocarcinoma">Grade 1 Colorectal Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/272680" ref="tree=MeSH" title="MedGen record for Grade 2 Colorectal Adenocarcinoma">Grade 2 Colorectal Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/232251" ref="tree=MeSH" title="MedGen record for Grade 3 Colorectal Adenocarcinoma">Grade 3 Colorectal Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1753872" ref="tree=MeSH" title="MedGen record for Inflammatory Bowel Disease-Associated Colorectal Adenocarcinoma">Inflammatory Bowel Disease-Associated Colorectal Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1693675" ref="tree=MeSH" title="MedGen record for Metastatic Colorectal Adenocarcinoma">Metastatic Colorectal Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/328341" ref="tree=MeSH" title="MedGen record for Rectosigmoid Adenocarcinoma">Rectosigmoid Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/56214" ref="tree=MeSH" title="MedGen record for Rectum adenocarcinoma">Rectum adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1705592" ref="tree=MeSH" title="MedGen record for Recurrent Colorectal Adenocarcinoma">Recurrent Colorectal Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1699112" ref="tree=MeSH" title="MedGen record for Refractory Colorectal Adenocarcinoma">Refractory Colorectal Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1747614" ref="tree=MeSH" title="MedGen record for Unresectable Colorectal Adenocarcinoma">Unresectable Colorectal Adenocarcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/859263" ref="tree=MeSH" title="MedGen record for Childhood Colorectal Carcinoma">Childhood Colorectal Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/859237" ref="tree=MeSH" title="MedGen record for Childhood Rectal Carcinoma">Childhood Rectal Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/317524" ref="tree=MeSH" title="MedGen record for Colorectal adenosquamous carcinoma">Colorectal adenosquamous carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/313658" ref="tree=MeSH" title="MedGen record for Rectal adenosquamous carcinoma">Rectal adenosquamous carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/455932" ref="tree=MeSH" title="MedGen record for Colorectal Cancer by AJCC v6 Stage">Colorectal Cancer by AJCC v6 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/455934" ref="tree=MeSH" title="MedGen record for Rectal Cancer by AJCC v6 Stage">Rectal Cancer by AJCC v6 Stage</a></span></li><li><span class="TLline"><a href="/medgen/455935" ref="tree=MeSH" title="MedGen record for Rectosigmoid Cancer by AJCC v6 Stage">Rectosigmoid Cancer by AJCC v6 Stage</a></span></li><li><span class="TLline"><a href="/medgen/1619133" ref="tree=MeSH" title="MedGen record for Stage 0 Colorectal Cancer AJCC v6 and v7">Stage 0 Colorectal Cancer AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1624335" ref="tree=MeSH" title="MedGen record for Stage I Colorectal Cancer AJCC v6 and v7">Stage I Colorectal Cancer AJCC v6 and v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/456314" ref="tree=MeSH" title="MedGen record for Colorectal Cancer by AJCC v7 Stage">Colorectal Cancer by AJCC v7 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/456316" ref="tree=MeSH" title="MedGen record for Rectal Cancer by AJCC v7 Stage">Rectal Cancer by AJCC v7 Stage</a></span></li><li><span class="TLline"><a href="/medgen/456317" ref="tree=MeSH" title="MedGen record for Rectosigmoid Cancer by AJCC v7 Stage">Rectosigmoid Cancer by AJCC v7 Stage</a></span></li><li><span class="TLline"><a href="/medgen/459980" ref="tree=MeSH" title="MedGen record for Stage II Colorectal Cancer AJCC v7">Stage II Colorectal Cancer AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/459978" ref="tree=MeSH" title="MedGen record for Stage III Colorectal Cancer AJCC v7">Stage III Colorectal Cancer AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/459979" ref="tree=MeSH" title="MedGen record for Stage IV Colorectal Cancer AJCC v7">Stage IV Colorectal Cancer AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1612136" ref="tree=MeSH" title="MedGen record for Colorectal Cancer by AJCC v8 Stage">Colorectal Cancer by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1621761" ref="tree=MeSH" title="MedGen record for Rectal Cancer by AJCC v8 Stage">Rectal Cancer by AJCC v8 Stage</a></span></li><li><span class="TLline"><a href="/medgen/1622539" ref="tree=MeSH" title="MedGen record for Stage 0 Colorectal Cancer AJCC v8">Stage 0 Colorectal Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1623839" ref="tree=MeSH" title="MedGen record for Stage I Colorectal Cancer AJCC v8">Stage I Colorectal Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1626013" ref="tree=MeSH" title="MedGen record for Stage II Colorectal Cancer AJCC v8">Stage II Colorectal Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1621176" ref="tree=MeSH" title="MedGen record for Stage III Colorectal Cancer AJCC v8">Stage III Colorectal Cancer AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1611440" ref="tree=MeSH" title="MedGen record for Stage IV Colorectal Cancer AJCC v8">Stage IV Colorectal Cancer AJCC v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/474242" ref="tree=MeSH" title="MedGen record for Colorectal Mixed Adenoneuroendocrine Carcinoma">Colorectal Mixed Adenoneuroendocrine Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/474240" ref="tree=MeSH" title="MedGen record for Colorectal Neuroendocrine Carcinoma">Colorectal Neuroendocrine Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/474241" ref="tree=MeSH" title="MedGen record for Colorectal Large Cell Neuroendocrine Carcinoma">Colorectal Large Cell Neuroendocrine Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/313041" ref="tree=MeSH" title="MedGen record for Colorectal Small Cell Neuroendocrine Carcinoma">Colorectal Small Cell Neuroendocrine Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/474451" ref="tree=MeSH" title="MedGen record for Colorectal Sarcomatoid Carcinoma">Colorectal Sarcomatoid Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/235533" ref="tree=MeSH" title="MedGen record for Rectal sarcomatoid carcinoma">Rectal sarcomatoid carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/317527" ref="tree=MeSH" title="MedGen record for Colorectal squamous cell carcinoma">Colorectal squamous cell carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/235534" ref="tree=MeSH" title="MedGen record for Squamous cell carcinoma of rectum">Squamous cell carcinoma of rectum</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/310621" ref="tree=MeSH" title="MedGen record for Colorectal Undifferentiated Carcinoma">Colorectal Undifferentiated Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/234451" ref="tree=MeSH" title="MedGen record for Rectal Undifferentiated Carcinoma">Rectal Undifferentiated Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1696099" ref="tree=MeSH" title="MedGen record for Hypermutated Colorectal Carcinoma">Hypermutated Colorectal Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1662385" ref="tree=MeSH" title="MedGen record for Metastatic Colorectal Carcinoma">Metastatic Colorectal Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1690161" ref="tree=MeSH" title="MedGen record for Advanced Colorectal Carcinoma">Advanced Colorectal Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1673590" ref="tree=MeSH" title="MedGen record for Colorectal Carcinoma Metastatic in the Liver">Colorectal Carcinoma Metastatic in the Liver</a></span></li><li><span class="TLline"><a href="/medgen/1660557" ref="tree=MeSH" title="MedGen record for Colorectal Carcinoma Metastatic in the Lung">Colorectal Carcinoma Metastatic in the Lung</a></span></li><li><span class="TLline"><a href="/medgen/1704242" ref="tree=MeSH" title="MedGen record for Locally Advanced Colorectal Carcinoma">Locally Advanced Colorectal Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1641308" ref="tree=MeSH" title="MedGen record for Metastatic Microsatellite Stable Colorectal Carcinoma">Metastatic Microsatellite Stable Colorectal Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1666460" ref="tree=MeSH" title="MedGen record for Metastatic Rectal Carcinoma">Metastatic Rectal Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1771326" ref="tree=MeSH" title="MedGen record for Microsatellite Stable Colorectal Carcinoma">Microsatellite Stable Colorectal Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1791054" ref="tree=MeSH" title="MedGen record for Microsatellite Stable Rectal Carcinoma">Microsatellite Stable Rectal Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1725658" ref="tree=MeSH" title="MedGen record for Refractory Microsatellite Stable Colorectal Carcinoma">Refractory Microsatellite Stable Colorectal Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/40100" ref="tree=MeSH" title="MedGen record for Rectal carcinoma">Rectal carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1783224" ref="tree=MeSH" title="MedGen record for Rectal Large Cell Neuroendocrine Carcinoma">Rectal Large Cell Neuroendocrine Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/364315" ref="tree=MeSH" title="MedGen record for Rectal Small Cell Neuroendocrine Carcinoma">Rectal Small Cell Neuroendocrine Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/82940" ref="tree=MeSH" title="MedGen record for Recurrent Rectal Carcinoma">Recurrent Rectal Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1699689" ref="tree=MeSH" title="MedGen record for Refractory Rectal Carcinoma">Refractory Rectal Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/232963" ref="tree=MeSH" title="MedGen record for Rectosigmoid carcinoma">Rectosigmoid carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/167710" ref="tree=MeSH" title="MedGen record for Recurrent Rectosigmoid Carcinoma">Recurrent Rectosigmoid Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/163453" ref="tree=MeSH" title="MedGen record for Recurrent Colorectal Carcinoma">Recurrent Colorectal Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1636913" ref="tree=MeSH" title="MedGen record for Refractory Colorectal Carcinoma">Refractory Colorectal Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1688401" ref="tree=MeSH" title="MedGen record for Resectable Colorectal Carcinoma">Resectable Colorectal Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1700411" ref="tree=MeSH" title="MedGen record for Unresectable Colorectal Carcinoma">Unresectable Colorectal Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/474455" ref="tree=MeSH" title="MedGen record for Colorectal lymphoma">Colorectal lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/474457" ref="tree=MeSH" title="MedGen record for Colorectal Hodgkin Lymphoma">Colorectal Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/474456" ref="tree=MeSH" title="MedGen record for Colorectal Non-Hodgkin Lymphoma">Colorectal Non-Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/474459" ref="tree=MeSH" title="MedGen record for Colorectal Burkitt Lymphoma">Colorectal Burkitt Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/474460" ref="tree=MeSH" title="MedGen record for Colorectal diffuse large B-cell lymphoma">Colorectal diffuse large B-cell lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/474462" ref="tree=MeSH" title="MedGen record for Colorectal Mantle Cell Lymphoma">Colorectal Mantle Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/474463" ref="tree=MeSH" title="MedGen record for Colorectal Mucosa-Associated Lymphoid Tissue Lymphoma">Colorectal Mucosa-Associated Lymphoid Tissue Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/233393" ref="tree=MeSH" title="MedGen record for Rectum lymphoma">Rectum lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/474464" ref="tree=MeSH" title="MedGen record for Colorectal Sarcoma">Colorectal Sarcoma</a></span><ul><li><span class="TLline"><a href="/medgen/474467" ref="tree=MeSH" title="MedGen record for Colorectal Angiosarcoma">Colorectal Angiosarcoma</a></span></li><li><span class="TLline"><a href="/medgen/474466" ref="tree=MeSH" title="MedGen record for Colorectal Kaposi sarcoma">Colorectal Kaposi sarcoma</a></span><ul><li><span class="TLline"><a href="/medgen/277575" ref="tree=MeSH" title="MedGen record for Rectum Kaposi sarcoma">Rectum Kaposi sarcoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/474465" ref="tree=MeSH" title="MedGen record for Colorectal Leiomyosarcoma">Colorectal Leiomyosarcoma</a></span><ul><li><span class="TLline"><a href="/medgen/233391" ref="tree=MeSH" title="MedGen record for Rectum leiomyosarcoma">Rectum leiomyosarcoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/277577" ref="tree=MeSH" title="MedGen record for Rectum sarcoma">Rectum sarcoma</a></span><ul><li><span class="TLline"><a href="/medgen/235532" ref="tree=MeSH" title="MedGen record for Rectum rhabdomyosarcoma">Rectum rhabdomyosarcoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/965772" ref="tree=MeSH" title="MedGen record for Familial colorectal cancer">Familial colorectal cancer</a></span></li><li><span class="TLline"><a href="/medgen/181763" ref="tree=MeSH" title="MedGen record for Malignant tumor of rectum">Malignant tumor of rectum</a></span><ul><li><span class="TLline"><a href="/medgen/83433" ref="tree=MeSH" title="MedGen record for Metastatic Malignant Neoplasm in the Rectum">Metastatic Malignant Neoplasm in the Rectum</a></span></li><li><span class="TLline"><a href="/medgen/87605" ref="tree=MeSH" title="MedGen record for Rectum malignant melanoma">Rectum malignant melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1690980" ref="tree=MeSH" title="MedGen record for Metastatic Malignant Colorectal Neoplasm">Metastatic Malignant Colorectal Neoplasm</a></span></li><li><span class="TLline"><a href="/medgen/138071" ref="tree=MeSH" title="MedGen record for Metastatic Malignant Neoplasm in the Large Intestine">Metastatic Malignant Neoplasm in the Large Intestine</a></span></li><li><span class="TLline"><a href="/medgen/57558" ref="tree=MeSH" title="MedGen record for Rectosigmoid junction cancer">Rectosigmoid junction cancer</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_105">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
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<div class="nl"><a target="_blank" href="/pubmed/36307056">Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Cervantes A,
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Adam R,
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Roselló S,
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Arnold D,
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Normanno N,
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Taïeb J,
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Seligmann J,
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De Baere T,
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Osterlund P,
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Yoshino T,
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Martinelli E;
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ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org</span><br />
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<span class="medgenPMjournal">Ann Oncol</span>
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2023 Jan;34(1):10-32.
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Epub 2022 Oct 25
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doi: 10.1016/j.annonc.2022.10.003.
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<span class="bold">PMID: </span><a href="/pubmed/36307056" target="_blank">36307056</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/33922402">Artificial Intelligence in Colorectal Cancer Screening, Diagnosis and Treatment. A New Era.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Mitsala A,
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Tsalikidis C,
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Pitiakoudis M,
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Simopoulos C,
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Tsaroucha AK</span><br />
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<span class="medgenPMjournal">Curr Oncol</span>
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2021 Apr 23;28(3):1581-1607.
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doi: 10.3390/curroncol28030149.
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<span class="bold">PMID: </span><a href="/pubmed/33922402" target="_blank">33922402</a><a href="/pmc/articles/PMC8161764" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/33171427">Management of pain in colorectal cancer patients.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Zielińska A,
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Włodarczyk M,
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Makaro A,
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Sałaga M,
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Fichna J</span><br />
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<span class="medgenPMjournal">Crit Rev Oncol Hematol</span>
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2021 Jan;157:103122.
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Epub 2020 Oct 19
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doi: 10.1016/j.critrevonc.2020.103122.
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<span class="bold">PMID: </span><a href="/pubmed/33171427" target="_blank">33171427</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22colorectal%20cancer%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (6976)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nice.org.uk/guidance/ng151" target="_blank">UK NICE Guideline NG151, Colorectal cancer, 2021</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_114">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Suggested_Reading">Suggested Reading</h1><a sid="114" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/26389505">Genetics of Colorectal Cancer (PDQ®): Health Professional Version.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">PDQ Cancer Genetics Editorial Board</span><br />
|
||
|
||
2002
|
||
<span class="bold">PMID: </span><a href="/pubmed/26389505" target="_blank">26389505</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26389258">Cancer Genetics Risk Assessment and Counseling (PDQ®): Health Professional Version.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">PDQ Cancer Genetics Editorial Board</span><br />
|
||
|
||
2002
|
||
<span class="bold">PMID: </span><a href="/pubmed/26389258" target="_blank">26389258</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=" title="PubMed search"></a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37763765">Colorectal Cancer: From Risk Factors to Oncogenesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ionescu VA,
|
||
Gheorghe G,
|
||
Bacalbasa N,
|
||
Chiotoroiu AL,
|
||
Diaconu C</span><br />
|
||
<span class="medgenPMjournal">Medicina (Kaunas)</span>
|
||
2023 Sep 12;59(9)
|
||
doi: 10.3390/medicina59091646.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37763765" target="_blank">37763765</a><a href="/pmc/articles/PMC10537191" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36835094">The Ketogenic Diet in Colorectal Cancer: A Means to an End.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tamraz M,
|
||
Al Ghossaini N,
|
||
Temraz S</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2023 Feb 12;24(4)
|
||
doi: 10.3390/ijms24043683.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36835094" target="_blank">36835094</a><a href="/pmc/articles/PMC9965563" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35351271">Healthcare Disparities and Colorectal Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hollis RH,
|
||
Chu DI</span><br />
|
||
<span class="medgenPMjournal">Surg Oncol Clin N Am</span>
|
||
2022 Apr;31(2):157-169.
|
||
Epub 2022 Mar 8
|
||
doi: 10.1016/j.soc.2021.11.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35351271" target="_blank">35351271</a><a href="/pmc/articles/PMC8968072" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34940086">Pathological Features and Prognostication in Colorectal Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chen K,
|
||
Collins G,
|
||
Wang H,
|
||
Toh JWT</span><br />
|
||
<span class="medgenPMjournal">Curr Oncol</span>
|
||
2021 Dec 13;28(6):5356-5383.
|
||
doi: 10.3390/curroncol28060447.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34940086" target="_blank">34940086</a><a href="/pmc/articles/PMC8700531" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33518157">Colorectal Cancer and Diet: Risk Versus Prevention, Is Diet an Intervention?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhou E,
|
||
Rifkin S</span><br />
|
||
<span class="medgenPMjournal">Gastroenterol Clin North Am</span>
|
||
2021 Mar;50(1):101-111.
|
||
doi: 10.1016/j.gtc.2020.10.012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33518157" target="_blank">33518157</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Colorectal%20cancer%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (53239)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38909621">Colorectal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eng C,
|
||
Yoshino T,
|
||
Ruíz-García E,
|
||
Mostafa N,
|
||
Cann CG,
|
||
O'Brian B,
|
||
Benny A,
|
||
Perez RO,
|
||
Cremolini C</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2024 Jul 20;404(10449):294-310.
|
||
Epub 2024 Jun 20
|
||
doi: 10.1016/S0140-6736(24)00360-X.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38909621" target="_blank">38909621</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37763765">Colorectal Cancer: From Risk Factors to Oncogenesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ionescu VA,
|
||
Gheorghe G,
|
||
Bacalbasa N,
|
||
Chiotoroiu AL,
|
||
Diaconu C</span><br />
|
||
<span class="medgenPMjournal">Medicina (Kaunas)</span>
|
||
2023 Sep 12;59(9)
|
||
doi: 10.3390/medicina59091646.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37763765" target="_blank">37763765</a><a href="/pmc/articles/PMC10537191" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36410912">Colorectal Cancer Liver Metastases: Multimodal Therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Aykut B,
|
||
Lidsky ME</span><br />
|
||
<span class="medgenPMjournal">Surg Oncol Clin N Am</span>
|
||
2023 Jan;32(1):119-141.
|
||
Epub 2022 Nov 3
|
||
doi: 10.1016/j.soc.2022.07.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36410912" target="_blank">36410912</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35351271">Healthcare Disparities and Colorectal Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hollis RH,
|
||
Chu DI</span><br />
|
||
<span class="medgenPMjournal">Surg Oncol Clin N Am</span>
|
||
2022 Apr;31(2):157-169.
|
||
Epub 2022 Mar 8
|
||
doi: 10.1016/j.soc.2021.11.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35351271" target="_blank">35351271</a><a href="/pmc/articles/PMC8968072" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35090673">A comprehensive framework for early-onset colorectal cancer research.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eng C,
|
||
Jácome AA,
|
||
Agarwal R,
|
||
Hayat MH,
|
||
Byndloss MX,
|
||
Holowatyj AN,
|
||
Bailey C,
|
||
Lieu CH</span><br />
|
||
<span class="medgenPMjournal">Lancet Oncol</span>
|
||
2022 Mar;23(3):e116-e128.
|
||
Epub 2022 Jan 31
|
||
doi: 10.1016/S1470-2045(21)00588-X.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35090673" target="_blank">35090673</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Colorectal%20cancer%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (40316)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38467003">Long-Term Effect of Randomization to Calcium and Vitamin D Supplementation on Health in Older Women : Postintervention Follow-up of a Randomized Clinical Trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Thomson CA,
|
||
Aragaki AK,
|
||
Prentice RL,
|
||
Stefanick ML,
|
||
Manson JE,
|
||
Wactawski-Wende J,
|
||
Watts NB,
|
||
Van Horn L,
|
||
Shikany JM,
|
||
Rohan TE,
|
||
Lane DS,
|
||
Wild RA,
|
||
Robles-Morales R,
|
||
Shadyab AH,
|
||
Saquib N,
|
||
Cauley J</span><br />
|
||
<span class="medgenPMjournal">Ann Intern Med</span>
|
||
2024 Apr;177(4):428-438.
|
||
Epub 2024 Mar 12
|
||
doi: 10.7326/M23-2598.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38467003" target="_blank">38467003</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37701986">KEYSTEP-008: phase II trial of pembrolizumab-based combination in MSI-H/dMMR metastatic colorectal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">André T,
|
||
Pietrantonio F,
|
||
Avallone A,
|
||
Gumus M,
|
||
Wyrwicz L,
|
||
Kim JG,
|
||
Yalcin S,
|
||
Kwiatkowski M,
|
||
Lonardi S,
|
||
Zolnierek J,
|
||
Odeleye-Ajakaye A,
|
||
Leconte P,
|
||
Fogelman D,
|
||
Kim TW</span><br />
|
||
<span class="medgenPMjournal">Future Oncol</span>
|
||
2023 Dec;19(37):2445-2452.
|
||
Epub 2023 Sep 13
|
||
doi: 10.2217/fon-2022-1105.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37701986" target="_blank">37701986</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33993740">FRESCO-2: a global Phase III study investigating the efficacy and safety of fruquintinib in metastatic colorectal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dasari A,
|
||
Sobrero A,
|
||
Yao J,
|
||
Yoshino T,
|
||
Schelman W,
|
||
Yang Z,
|
||
Chien C,
|
||
Kania M,
|
||
Tabernero J,
|
||
Eng C</span><br />
|
||
<span class="medgenPMjournal">Future Oncol</span>
|
||
2021 Aug;17(24):3151-3162.
|
||
Epub 2021 May 17
|
||
doi: 10.2217/fon-2021-0202.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33993740" target="_blank">33993740</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33931919">CIRCULATE-Japan: Circulating tumor DNA-guided adaptive platform trials to refine adjuvant therapy for colorectal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Taniguchi H,
|
||
Nakamura Y,
|
||
Kotani D,
|
||
Yukami H,
|
||
Mishima S,
|
||
Sawada K,
|
||
Shirasu H,
|
||
Ebi H,
|
||
Yamanaka T,
|
||
Aleshin A,
|
||
Billings PR,
|
||
Rabinowitz M,
|
||
Oki E,
|
||
Takemasa I,
|
||
Kato T,
|
||
Mori M,
|
||
Yoshino T</span><br />
|
||
<span class="medgenPMjournal">Cancer Sci</span>
|
||
2021 Jul;112(7):2915-2920.
|
||
Epub 2021 Jun 7
|
||
doi: 10.1111/cas.14926.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33931919" target="_blank">33931919</a><a href="/pmc/articles/PMC8253296" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33595891">Immunotherapy for the treatment of colorectal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lumish MA,
|
||
Cercek A</span><br />
|
||
<span class="medgenPMjournal">J Surg Oncol</span>
|
||
2021 Mar;123(3):760-774.
|
||
doi: 10.1002/jso.26357.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33595891" target="_blank">33595891</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Colorectal%20cancer%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (33354)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32133645">Colorectal cancer statistics, 2020.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Siegel RL,
|
||
Miller KD,
|
||
Goding Sauer A,
|
||
Fedewa SA,
|
||
Butterly LF,
|
||
Anderson JC,
|
||
Cercek A,
|
||
Smith RA,
|
||
Jemal A</span><br />
|
||
<span class="medgenPMjournal">CA Cancer J Clin</span>
|
||
2020 May;70(3):145-164.
|
||
Epub 2020 Mar 5
|
||
doi: 10.3322/caac.21601.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32133645" target="_blank">32133645</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31812369">Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Arbyn M,
|
||
Weiderpass E,
|
||
Bruni L,
|
||
de Sanjosé S,
|
||
Saraiya M,
|
||
Ferlay J,
|
||
Bray F</span><br />
|
||
<span class="medgenPMjournal">Lancet Glob Health</span>
|
||
2020 Feb;8(2):e191-e203.
|
||
Epub 2019 Dec 4
|
||
doi: 10.1016/S2214-109X(19)30482-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31812369" target="_blank">31812369</a><a href="/pmc/articles/PMC7025157" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30207593">Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bray F,
|
||
Ferlay J,
|
||
Soerjomataram I,
|
||
Siegel RL,
|
||
Torre LA,
|
||
Jemal A</span><br />
|
||
<span class="medgenPMjournal">CA Cancer J Clin</span>
|
||
2018 Nov;68(6):394-424.
|
||
Epub 2018 Sep 12
|
||
doi: 10.3322/caac.21492.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30207593" target="_blank">30207593</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26818619">Global patterns and trends in colorectal cancer incidence and mortality.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Arnold M,
|
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Sierra MS,
|
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Laversanne M,
|
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Soerjomataram I,
|
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Jemal A,
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Bray F</span><br />
|
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<span class="medgenPMjournal">Gut</span>
|
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2017 Apr;66(4):683-691.
|
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Epub 2016 Jan 27
|
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doi: 10.1136/gutjnl-2015-310912.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26818619" target="_blank">26818619</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24225001">Colorectal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brenner H,
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Kloor M,
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Pox CP</span><br />
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<span class="medgenPMjournal">Lancet</span>
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2014 Apr 26;383(9927):1490-1502.
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Epub 2013 Nov 11
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<span class="bold">PMID: </span><a href="/pubmed/24225001" target="_blank">24225001</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Colorectal%20cancer%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (42228)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38342196">Colonoscopy vs the Fecal Immunochemical Test: Which is Best?</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Robertson DJ,
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Rex DK,
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Ciani O,
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Drummond MF</span><br />
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<span class="medgenPMjournal">Gastroenterology</span>
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2024 May;166(5):758-771.
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Epub 2024 Feb 9
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doi: 10.1053/j.gastro.2023.12.027.
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<span class="bold">PMID: </span><a href="/pubmed/38342196" target="_blank">38342196</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/34360768">Inflammation-Related Biomarkers for the Prediction of Prognosis in Colorectal Cancer Patients.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Yamamoto T,
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Kawada K,
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Obama K</span><br />
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<span class="medgenPMjournal">Int J Mol Sci</span>
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2021 Jul 27;22(15)
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doi: 10.3390/ijms22158002.
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<span class="bold">PMID: </span><a href="/pubmed/34360768" target="_blank">34360768</a><a href="/pmc/articles/PMC8348168" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div class="nl"><a target="_blank" href="/pubmed/33989659">Hopes and Hypes for Artificial Intelligence in Colorectal Cancer Screening.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Mori Y,
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Bretthauer M,
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Kalager M</span><br />
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<span class="medgenPMjournal">Gastroenterology</span>
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2021 Sep;161(3):774-777.
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Epub 2021 May 11
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doi: 10.1053/j.gastro.2021.04.078.
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<span class="bold">PMID: </span><a href="/pubmed/33989659" target="_blank">33989659</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/28548122">Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Lugli A,
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Kirsch R,
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Ajioka Y,
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Bosman F,
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Cathomas G,
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Dawson H,
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El Zimaity H,
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Fléjou JF,
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Hansen TP,
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Hartmann A,
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Kakar S,
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Langner C,
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Nagtegaal I,
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Puppa G,
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Riddell R,
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<span class="medgenPMjournal">Mod Pathol</span>
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2017 Sep;30(9):1299-1311.
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<span class="bold">PMID: </span><a href="/pubmed/28548122" target="_blank">28548122</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/24122236">Towards the introduction of the 'Immunoscore' in the classification of malignant tumours.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Galon J,
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Botti G,
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Hafezi-Bakhtiari S,
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Wouters BG,
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Roehrl M,
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Nguyen L,
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Kawakami Y,
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Hazama S,
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Okuno K,
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Ogino S,
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Gibbs P,
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Waring P,
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Shukla SN,
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2014 Jan;232(2):199-209.
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<span class="bold">PMID: </span><a href="/pubmed/24122236" target="_blank">24122236</a><a href="/pmc/articles/PMC4255306" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Colorectal%20cancer%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (38336)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/34844135">Resilience and related factors in colorectal cancer patients: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sihvola S,
|
||
Kuosmanen L,
|
||
Kvist T</span><br />
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<span class="medgenPMjournal">Eur J Oncol Nurs</span>
|
||
2022 Feb;56:102079.
|
||
Epub 2021 Nov 23
|
||
doi: 10.1016/j.ejon.2021.102079.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34844135" target="_blank">34844135</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32314192">Social determinants of colorectal cancer risk, stage, and survival: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Coughlin SS</span><br />
|
||
<span class="medgenPMjournal">Int J Colorectal Dis</span>
|
||
2020 Jun;35(6):985-995.
|
||
Epub 2020 Apr 21
|
||
doi: 10.1007/s00384-020-03585-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32314192" target="_blank">32314192</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31578199">Colorectal cancer screening with faecal testing, sigmoidoscopy or colonoscopy: a systematic review and network meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jodal HC,
|
||
Helsingen LM,
|
||
Anderson JC,
|
||
Lytvyn L,
|
||
Vandvik PO,
|
||
Emilsson L</span><br />
|
||
<span class="medgenPMjournal">BMJ Open</span>
|
||
2019 Oct 2;9(10):e032773.
|
||
doi: 10.1136/bmjopen-2019-032773.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31578199" target="_blank">31578199</a><a href="/pmc/articles/PMC6797379" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29210053">Food groups and risk of colorectal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schwingshackl L,
|
||
Schwedhelm C,
|
||
Hoffmann G,
|
||
Knüppel S,
|
||
Laure Preterre A,
|
||
Iqbal K,
|
||
Bechthold A,
|
||
De Henauw S,
|
||
Michels N,
|
||
Devleesschauwer B,
|
||
Boeing H,
|
||
Schlesinger S</span><br />
|
||
<span class="medgenPMjournal">Int J Cancer</span>
|
||
2018 May 1;142(9):1748-1758.
|
||
Epub 2017 Dec 14
|
||
doi: 10.1002/ijc.31198.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29210053" target="_blank">29210053</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28935150">Mediterranean diet and colorectal cancer: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Farinetti A,
|
||
Zurlo V,
|
||
Manenti A,
|
||
Coppi F,
|
||
Mattioli AV</span><br />
|
||
<span class="medgenPMjournal">Nutrition</span>
|
||
2017 Nov-Dec;43-44:83-88.
|
||
Epub 2017 Jul 8
|
||
doi: 10.1016/j.nut.2017.06.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28935150" target="_blank">28935150</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Colorectal%20cancer%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2695)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
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|
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|
||
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|
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|
||
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|
||
|
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|
||
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|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
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|
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|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0346629%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (91)</a></li>
|
||
<li><a href="/gtr/tests?term=C0346629%5bDISCUI%5d&filter=method%3A3%5F31" target="_blank">Fluorescence in situ hybridization (FISH) (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0346629%5bDISCUI%5d&filter=method%3A2%5F15" target="_blank">Methylation analysis (3)</a></li>
|
||
<li><a href="/gtr/tests?term=C0346629%5bDISCUI%5d&filter=method%3A2%5F12" target="_blank">Microsatellite instability testing (MSI) (4)</a></li>
|
||
<li><a href="/gtr/tests?term=C0346629%5bDISCUI%5d&filter=method%3A2%5F18" target="_blank">Mutation scanning of select exons (4)</a></li>
|
||
<li><a href="/gtr/tests?term=C0346629%5bDISCUI%5d&filter=method%3A2%5F17" target="_blank">Mutation scanning of the entire coding region (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0346629%5bDISCUI%5d&filter=method%3A1%5F4" target="_blank">Protein analysis (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0346629%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (12)</a></li>
|
||
<li><a href="/gtr/tests?term=C0346629%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (126)</a></li>
|
||
<li><a href="/gtr/tests?term=C0346629%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (27)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0346629%5bDISCUI%5d" target="_blank">See all (188)</a></total></li>
|
||
</ul></div>
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</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22colorectal%20cancer%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Colorectal%20cancer%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nice.org.uk/guidance/ng151">NICE, 2021</a><div>UK NICE Guideline NG151, Colorectal cancer, 2021</div></li></ul></div>
|
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|
||
<div class="portlet mgSection" id="ID_115">
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|
||
<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=116806%20120470%20134934%20159350%20164730%20164757%20164790%20168461%20171834%20172411%20190090%20191170%20600040%20600079%20600925%20602452%20602700%20602860%20603028%20603072%20604025%20604258%20604289%20604395%20604584%20607273%20611731" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=207[geneid]" target="_blank">View AKT1 variations in ClinVar</a></li><li><a href="/clinvar/?term=324[geneid]" target="_blank">View APC variations in ClinVar</a></li><li><a href="/clinvar/?term=581[geneid]" target="_blank">View BAX variations in ClinVar</a></li><li><a href="/clinvar/?term=595[geneid]" target="_blank">View CCND1 variations in ClinVar</a></li><li><a href="/clinvar/?term=673[geneid]" target="_blank">View BRAF variations in ClinVar</a></li><li><a href="/clinvar/?term=699[geneid]" target="_blank">View BUB1 variations in ClinVar</a></li><li><a href="/clinvar/?term=701[geneid]" target="_blank">View BUB1B variations in ClinVar</a></li><li><a href="/clinvar/?term=1499[geneid]" target="_blank">View CTNNB1 variations in ClinVar</a></li><li><a href="/clinvar/?term=1630[geneid]" target="_blank">View DCC variations in ClinVar</a></li><li><a href="/clinvar/?term=2033[geneid]" target="_blank">View EP300 variations in ClinVar</a></li><li><a href="/clinvar/?term=2261[geneid]" target="_blank">View FGFR3 variations in ClinVar</a></li><li><a href="/clinvar/?term=4163[geneid]" target="_blank">View MCC variations in ClinVar</a></li><li><a href="/clinvar/?term=4893[geneid]" target="_blank">View NRAS variations in ClinVar</a></li><li><a href="/clinvar/?term=5157[geneid]" target="_blank">View PDGFRL variations in ClinVar</a></li><li><a href="/clinvar/?term=5290[geneid]" target="_blank">View PIK3CA variations in ClinVar</a></li><li><a href="/clinvar/?term=5320[geneid]" target="_blank">View PLA2G2A variations in ClinVar</a></li><li><a href="/clinvar/?term=5782[geneid]" target="_blank">View PTPN12 variations in ClinVar</a></li><li><a href="/clinvar/?term=5795[geneid]" target="_blank">View PTPRJ variations in ClinVar</a></li><li><a href="/clinvar/?term=6714[geneid]" target="_blank">View SRC variations in ClinVar</a></li><li><a href="/clinvar/?term=6790[geneid]" target="_blank">View AURKA variations in ClinVar</a></li><li><a href="/clinvar/?term=7097[geneid]" target="_blank">View TLR2 variations in ClinVar</a></li><li><a href="/clinvar/?term=7157[geneid]" target="_blank">View TP53 variations in ClinVar</a></li><li><a href="/clinvar/?term=8313[geneid]" target="_blank">View AXIN2 variations in ClinVar</a></li><li><a href="/clinvar/?term=10395[geneid]" target="_blank">View DLC1 variations in ClinVar</a></li><li><a href="/clinvar/?term=25788[geneid]" target="_blank">View RAD54B variations in ClinVar</a></li><li><a href="/clinvar/?term=27030[geneid]" target="_blank">View MLH3 variations in ClinVar</a></li><li><a href="/clinvar/?term=201163[geneid]" target="_blank">View FLCN variations in ClinVar</a></li><li><a href="/nuccore/166795258,187423895,188595650,190194382,197245371,207443680,223972657,237820661,237858595,237858742,237858793,237874257,237874277,238018091,238814316,255522834,257743479,259013234,262072976,262331527,269954696,281332105,283806584,293651587,298919191,299116992,300244558" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=114500" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
|
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|
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<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Colorectal+Cancer/1746" target="_blank">Genetic Alliance</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Colorectal%20cancer" target="_blank">MedlinePlus</a></li></ul></div>
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<h3>Reviews</h3>
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<a href="/pubmed/20301390" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=3" target="_blank"><span class="gene_reviews">GeneReviews</span></a>
|
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|
||
<a href="/pubmed/clinical?term=Colorectal%20cancer" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=3" target="_blank">PubMed Clinical Queries</a>
|
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|
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<li>
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<a href="/pubmed?term=Colorectal%20cancer%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=3&linkpostotal=3" target="_blank">Reviews in PubMed</a>
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<div class="portlet_content DiscoveryDbLinks">
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<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=83428" ref="log$=recordlinks">ClinVar</a>
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<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
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<a class="brieflinkpopperctrl" href="/gene?LinkName=medgen_gene_diseases&from_uid=83428" ref="log$=recordlinks">Gene</a>
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<div class="brieflinkpop offscreen_noflow">Related information in NCBI Gene</div>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0346629[DISCUI]" ref="log$=recordlinks">GTR</a>
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<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0346629[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
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<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
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|
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<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim&from_uid=83428" ref="log$=recordlinks">OMIM</a>
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<div class="brieflinkpop offscreen_noflow">Related records in OMIM</div>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim_gene&from_uid=83428" ref="log$=recordlinks">OMIM(Genes)</a>
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<div class="brieflinkpop offscreen_noflow">OMIM records containing genes associated with phenotypes registered in MedGen</div>
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<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=83428" ref="log$=recordlinks">PMC Articles</a>
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<div class="brieflinkpop offscreen_noflow">Related information in PubMed Central Links</div>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&from_uid=83428" ref="log$=recordlinks">PubMed</a>
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<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
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</li>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_bookshelf_cited&from_uid=83428" ref="log$=recordlinks">PubMed (Bookshelf cited)</a>
|
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<div class="brieflinkpop offscreen_noflow">Links to PubMed based on citations in GeneReviews and Medical Genetics Summaries</div>
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</li>
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<li class="brieflinkpopper">
|
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<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_genereviews&from_uid=83428" ref="log$=recordlinks">PubMed (GeneReviews)</a>
|
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<div class="brieflinkpop offscreen_noflow">GeneReviews in PubMed</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67ca6e58a68b6b5afc796bd8">Colorectal cancer</a>
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<div class="ralinkpop offscreen_noflow">Colorectal cancer<div class="brieflinkpopdesc"></div></div>
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<div class="tertiary">MedGen</div>
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<a class="htb" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67ca6e55b15b832ebc0e9eb8">C0346629[conceptid] <span class="number">(1)</span></a>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67ca6e54a68b6b5afc7958e0">C4479654[trait identifier] AND "Labcorp Genetics (formerly Invita... <span class="number">(51)</span></a>
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<div class="ralinkpop offscreen_noflow">C4479654[trait identifier] AND "Labcorp Genetics (formerly Invitae), Labcorp"[submitter]<div class="brieflinkpopdesc">Search</div></div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67ca6e53b15b832ebc0e9636">Cohen-Gibson syndrome</a>
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<div class="tertiary">MedGen</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67ca6e52f4a390645e466968">C0265223[trait identifier] AND "Labcorp Genetics (formerly Invita... <span class="number">(5124)</span></a>
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<div class="ralinkpop offscreen_noflow">C0265223[trait identifier] AND "Labcorp Genetics (formerly Invitae), Labcorp"[submitter]<div class="brieflinkpopdesc">Search</div></div>
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<div class="tertiary">ClinVar</div>
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