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<meta name="keywords" content="C0282193, disease or syndrome, increased storage iron, iron excess, iron overload, overload, iron, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Accumulation of iron in the tissues. It may be a manifestation of an inherited disorder (e.g., hemochromatosis) or acquired (in patients with repeated blood transfusions). Symptoms include hepatomegaly, arthritis, diabetes mellitus, and bronzed skin. If untreated it has a progressive course and may lead to death." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
|
||
UID=79398
|
||
ConceptID=C0282193
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Iron Overload</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>79398</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0282193</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Overload, Iron</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Iron overload (60737008); Increased storage iron (60737008); Iron excess (60737008)</td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Accumulation of iron in the tissues. It may be a manifestation of an inherited disorder (e.g., hemochromatosis) or acquired (in patients with repeated blood transfusions). Symptoms include hepatomegaly, arthritis, diabetes mellitus, and bronzed skin. If untreated it has a progressive course and may lead to death. [from <a title="NCI Thesaurus" href="http://ncit.nci.nih.gov" class="defSource" target="_blank">NCI</a>]</div>
|
||
</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Iron Overload</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/19974" ref="tree=MeSH" title="MedGen record for Clinical finding">Clinical finding</a></span><ul><li><span class="TLline"><a href="/medgen/232191" ref="tree=MeSH" title="MedGen record for Finding by Cause">Finding by Cause</a></span><ul><li><span class="matched_ds">Iron Overload</span><ul><li><span class="TLline"><a href="/medgen/5492" ref="tree=MeSH" title="MedGen record for Bronze diabetes">Bronze diabetes</a></span><ul><li><span class="TLline"><a href="/medgen/140272" ref="tree=MeSH" title="MedGen record for Hereditary hemochromatosis">Hereditary hemochromatosis</a></span><ul><li><span class="TLline"><a href="/medgen/854011" ref="tree=MeSH" title="MedGen record for Hemochromatosis type 1">Hemochromatosis type 1</a></span></li><li><span class="TLline"><a href="/medgen/388114" ref="tree=MeSH" title="MedGen record for Hemochromatosis type 3">Hemochromatosis type 3</a></span></li><li><span class="TLline"><a href="/medgen/340044" ref="tree=MeSH" title="MedGen record for Hemochromatosis type 4">Hemochromatosis type 4</a></span></li><li><span class="TLline"><a href="/medgen/341982" ref="tree=MeSH" title="MedGen record for Hemochromatosis type 5">Hemochromatosis type 5</a></span></li><li><span class="TLline"><a href="/medgen/417706" ref="tree=MeSH" title="MedGen record for HFE-Associated Hereditary Hemochromatosis">HFE-Associated Hereditary Hemochromatosis</a></span></li><li><span class="TLline"><a href="/medgen/82769" ref="tree=MeSH" title="MedGen record for Juvenile hemochromatosis">Juvenile hemochromatosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/82768" ref="tree=MeSH" title="MedGen record for Neonatal hemochromatosis">Neonatal hemochromatosis</a></span></li><li><span class="TLline"><a href="/medgen/536772" ref="tree=MeSH" title="MedGen record for Secondary hemochromatosis">Secondary hemochromatosis</a></span><ul><li><span class="TLline"><a href="/medgen/541170" ref="tree=MeSH" title="MedGen record for Transfusion hemosiderosis">Transfusion hemosiderosis</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/42409" ref="tree=MeSH" title="MedGen record for Hemosiderosis">Hemosiderosis</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35662478">EASL Clinical Practice Guidelines on haemochromatosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">European Association for the Study of the Liver</span><br />
|
||
<span class="medgenPMjournal">J Hepatol</span>
|
||
2022 Aug;77(2):479-502.
|
||
Epub 2022 Jun 1
|
||
doi: 10.1016/j.jhep.2022.03.033.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35662478" target="_blank">35662478</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34738740">Current status of beta-thalassemia and its treatment strategies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ali S,
|
||
Mumtaz S,
|
||
Shakir HA,
|
||
Khan M,
|
||
Tahir HM,
|
||
Mumtaz S,
|
||
Mughal TA,
|
||
Hassan A,
|
||
Kazmi SAR,
|
||
Sadia,
|
||
Irfan M,
|
||
Khan MA</span><br />
|
||
<span class="medgenPMjournal">Mol Genet Genomic Med</span>
|
||
2021 Dec;9(12):e1788.
|
||
Epub 2021 Nov 5
|
||
doi: 10.1002/mgg3.1788.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34738740" target="_blank">34738740</a><a href="/pmc/articles/PMC8683628" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31335359">ACG Clinical Guideline: Hereditary Hemochromatosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kowdley KV,
|
||
Brown KE,
|
||
Ahn J,
|
||
Sundaram V</span><br />
|
||
<span class="medgenPMjournal">Am J Gastroenterol</span>
|
||
2019 Aug;114(8):1202-1218.
|
||
doi: 10.14309/ajg.0000000000000315.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31335359" target="_blank">31335359</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22iron%20overload%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (580)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38068803">The IRONy in Athletic Performance.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kardasis W,
|
||
Naquin ER,
|
||
Garg R,
|
||
Arun T,
|
||
Gopianand JS,
|
||
Karmakar E,
|
||
Gnana-Prakasam JP</span><br />
|
||
<span class="medgenPMjournal">Nutrients</span>
|
||
2023 Nov 28;15(23)
|
||
doi: 10.3390/nu15234945.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38068803" target="_blank">38068803</a><a href="/pmc/articles/PMC10708480" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36907609">Clinical Complications and Their Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bou-Fakhredin R,
|
||
Motta I,
|
||
Cappellini MD,
|
||
Taher AT</span><br />
|
||
<span class="medgenPMjournal">Hematol Oncol Clin North Am</span>
|
||
2023 Apr;37(2):365-378.
|
||
doi: 10.1016/j.hoc.2022.12.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36907609" target="_blank">36907609</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36708354">Iron chelation therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bruzzese A,
|
||
Martino EA,
|
||
Mendicino F,
|
||
Lucia E,
|
||
Olivito V,
|
||
Bova C,
|
||
Filippelli G,
|
||
Capodanno I,
|
||
Neri A,
|
||
Morabito F,
|
||
Gentile M,
|
||
Vigna E</span><br />
|
||
<span class="medgenPMjournal">Eur J Haematol</span>
|
||
2023 May;110(5):490-497.
|
||
Epub 2023 Feb 8
|
||
doi: 10.1111/ejh.13935.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36708354" target="_blank">36708354</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36137277">Iron and the Pathophysiology of Diabetes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Harrison AV,
|
||
Lorenzo FR,
|
||
McClain DA</span><br />
|
||
<span class="medgenPMjournal">Annu Rev Physiol</span>
|
||
2023 Feb 10;85:339-362.
|
||
Epub 2022 Sep 22
|
||
doi: 10.1146/annurev-physiol-022522-102832.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36137277" target="_blank">36137277</a><a href="/pmc/articles/PMC10161568" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35289581">Alpha- and Beta-thalassemia: Rapid Evidence Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Baird DC,
|
||
Batten SH,
|
||
Sparks SK</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2022 Mar 1;105(3):272-280.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35289581" target="_blank">35289581</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Iron%20Overload%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3670)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37121243">Haemochromatosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Adams PC,
|
||
Jeffrey G,
|
||
Ryan J</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2023 May 27;401(10390):1811-1821.
|
||
Epub 2023 Apr 27
|
||
doi: 10.1016/S0140-6736(23)00287-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37121243" target="_blank">37121243</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36708354">Iron chelation therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bruzzese A,
|
||
Martino EA,
|
||
Mendicino F,
|
||
Lucia E,
|
||
Olivito V,
|
||
Bova C,
|
||
Filippelli G,
|
||
Capodanno I,
|
||
Neri A,
|
||
Morabito F,
|
||
Gentile M,
|
||
Vigna E</span><br />
|
||
<span class="medgenPMjournal">Eur J Haematol</span>
|
||
2023 May;110(5):490-497.
|
||
Epub 2023 Feb 8
|
||
doi: 10.1111/ejh.13935.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36708354" target="_blank">36708354</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35699322">Iron overload disorders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hsu CC,
|
||
Senussi NH,
|
||
Fertrin KY,
|
||
Kowdley KV</span><br />
|
||
<span class="medgenPMjournal">Hepatol Commun</span>
|
||
2022 Aug;6(8):1842-1854.
|
||
Epub 2022 Jun 14
|
||
doi: 10.1002/hep4.2012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35699322" target="_blank">35699322</a><a href="/pmc/articles/PMC9315134" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34755596">The Evaluation of Iron Deficiency and Iron Overload.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gattermann N,
|
||
Muckenthaler MU,
|
||
Kulozik AE,
|
||
Metzgeroth G,
|
||
Hastka J</span><br />
|
||
<span class="medgenPMjournal">Dtsch Arztebl Int</span>
|
||
2021 Dec 10;118(49):847-856.
|
||
doi: 10.3238/arztebl.m2021.0290.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34755596" target="_blank">34755596</a><a href="/pmc/articles/PMC8941656" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34261579">Hemochromatoses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brissot P,
|
||
Loréal O</span><br />
|
||
<span class="medgenPMjournal">J Hepatol</span>
|
||
2021 Sep;75(3):723-724.
|
||
Epub 2021 Jul 11
|
||
doi: 10.1016/j.jhep.2021.04.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34261579" target="_blank">34261579</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Iron%20Overload%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2966)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37700499">Cardiac magnetic resonance biomarkers as surrogate endpoints in cardiovascular trials for myocardial diseases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Benz DC,
|
||
Gräni C,
|
||
Antiochos P,
|
||
Heydari B,
|
||
Gissler MC,
|
||
Ge Y,
|
||
Cuddy SAM,
|
||
Dorbala S,
|
||
Kwong RY</span><br />
|
||
<span class="medgenPMjournal">Eur Heart J</span>
|
||
2023 Dec 1;44(45):4738-4747.
|
||
doi: 10.1093/eurheartj/ehad510.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37700499" target="_blank">37700499</a><a href="/pmc/articles/PMC11032206" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36907614">Emerging Therapies in β-Thalassemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bou-Fakhredin R,
|
||
Kuo KHM,
|
||
Taher AT</span><br />
|
||
<span class="medgenPMjournal">Hematol Oncol Clin North Am</span>
|
||
2023 Apr;37(2):449-462.
|
||
doi: 10.1016/j.hoc.2022.12.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36907614" target="_blank">36907614</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36708354">Iron chelation therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bruzzese A,
|
||
Martino EA,
|
||
Mendicino F,
|
||
Lucia E,
|
||
Olivito V,
|
||
Bova C,
|
||
Filippelli G,
|
||
Capodanno I,
|
||
Neri A,
|
||
Morabito F,
|
||
Gentile M,
|
||
Vigna E</span><br />
|
||
<span class="medgenPMjournal">Eur J Haematol</span>
|
||
2023 May;110(5):490-497.
|
||
Epub 2023 Feb 8
|
||
doi: 10.1111/ejh.13935.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36708354" target="_blank">36708354</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35179250">Optic neuropathy in iron overload and iron chelation therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Melachuri S,
|
||
Lim CC,
|
||
Winters J</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
2022 May;97(5):670-672.
|
||
Epub 2022 Feb 25
|
||
doi: 10.1002/ajh.26511.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35179250" target="_blank">35179250</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20564545">Milk thistle in liver diseases: past, present, future.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Abenavoli L,
|
||
Capasso R,
|
||
Milic N,
|
||
Capasso F</span><br />
|
||
<span class="medgenPMjournal">Phytother Res</span>
|
||
2010 Oct;24(10):1423-32.
|
||
doi: 10.1002/ptr.3207.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20564545" target="_blank">20564545</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Iron%20Overload%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3092)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34617272">Guidelines for the monitoring and management of iron overload in patients with haemoglobinopathies and rare anaemias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shah FT,
|
||
Porter JB,
|
||
Sadasivam N,
|
||
Kaya B,
|
||
Moon JC,
|
||
Velangi M,
|
||
Ako E,
|
||
Pancham S</span><br />
|
||
<span class="medgenPMjournal">Br J Haematol</span>
|
||
2022 Jan;196(2):336-350.
|
||
Epub 2021 Oct 6
|
||
doi: 10.1111/bjh.17839.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34617272" target="_blank">34617272</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34738740">Current status of beta-thalassemia and its treatment strategies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ali S,
|
||
Mumtaz S,
|
||
Shakir HA,
|
||
Khan M,
|
||
Tahir HM,
|
||
Mumtaz S,
|
||
Mughal TA,
|
||
Hassan A,
|
||
Kazmi SAR,
|
||
Sadia,
|
||
Irfan M,
|
||
Khan MA</span><br />
|
||
<span class="medgenPMjournal">Mol Genet Genomic Med</span>
|
||
2021 Dec;9(12):e1788.
|
||
Epub 2021 Nov 5
|
||
doi: 10.1002/mgg3.1788.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34738740" target="_blank">34738740</a><a href="/pmc/articles/PMC8683628" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32886826">Changing patterns in the epidemiology of β-thalassemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kattamis A,
|
||
Forni GL,
|
||
Aydinok Y,
|
||
Viprakasit V</span><br />
|
||
<span class="medgenPMjournal">Eur J Haematol</span>
|
||
2020 Dec;105(6):692-703.
|
||
Epub 2020 Sep 21
|
||
doi: 10.1111/ejh.13512.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32886826" target="_blank">32886826</a><a href="/pmc/articles/PMC7692954" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20001636">Update on survival in thalassemia major.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Telfer P</span><br />
|
||
<span class="medgenPMjournal">Hemoglobin</span>
|
||
2009;33 Suppl 1:S76-80.
|
||
doi: 10.3109/03630260903347336.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20001636" target="_blank">20001636</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15763231">Effect of alcohol on viral hepatitis and other forms of liver dysfunction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Balasubramanian S,
|
||
Kowdley KV</span><br />
|
||
<span class="medgenPMjournal">Clin Liver Dis</span>
|
||
2005 Feb;9(1):83-101.
|
||
doi: 10.1016/j.cld.2004.10.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15763231" target="_blank">15763231</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Iron%20Overload%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1589)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35981695">Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang W,
|
||
Jing X,
|
||
Du T,
|
||
Ren J,
|
||
Liu X,
|
||
Chen F,
|
||
Shao Y,
|
||
Sun S,
|
||
Yang G,
|
||
Cui X</span><br />
|
||
<span class="medgenPMjournal">Free Radic Biol Med</span>
|
||
2022 Sep;190:234-246.
|
||
Epub 2022 Aug 15
|
||
doi: 10.1016/j.freeradbiomed.2022.08.018.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35981695" target="_blank">35981695</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34090703">Iron metabolism: pathophysiology and pharmacology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Roemhild K,
|
||
von Maltzahn F,
|
||
Weiskirchen R,
|
||
Knüchel R,
|
||
von Stillfried S,
|
||
Lammers T</span><br />
|
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<span class="medgenPMjournal">Trends Pharmacol Sci</span>
|
||
2021 Aug;42(8):640-656.
|
||
Epub 2021 Jun 2
|
||
doi: 10.1016/j.tips.2021.05.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34090703" target="_blank">34090703</a><a href="/pmc/articles/PMC7611894" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20542038">Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pietrangelo A</span><br />
|
||
<span class="medgenPMjournal">Gastroenterology</span>
|
||
2010 Aug;139(2):393-408, 408.e1-2.
|
||
Epub 2010 Jun 11
|
||
doi: 10.1053/j.gastro.2010.06.013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20542038" target="_blank">20542038</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19414144">Hereditary haemochromatosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Janssen MC,
|
||
Swinkels DW</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Gastroenterol</span>
|
||
2009;23(2):171-83.
|
||
doi: 10.1016/j.bpg.2009.02.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19414144" target="_blank">19414144</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12707221">Clinical consequences of iron overload in hemochromatosis homozygotes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ajioka RS,
|
||
Kushner JP</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2003 May 1;101(9):3351-3; discussion 3354-8.
|
||
doi: 10.1182/blood-2002-11-3453.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12707221" target="_blank">12707221</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Iron%20Overload%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2347)</a></div></div>
|
||
</div>
|
||
|
||
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
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<div class="nl"><a target="_blank" href="/pubmed/36702249">Ferroptosis in acute kidney injury following crush syndrome: A novel target for treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Qiao O,
|
||
Wang X,
|
||
Wang Y,
|
||
Li N,
|
||
Gong Y</span><br />
|
||
<span class="medgenPMjournal">J Adv Res</span>
|
||
2023 Dec;54:211-222.
|
||
Epub 2023 Jan 24
|
||
doi: 10.1016/j.jare.2023.01.016.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36702249" target="_blank">36702249</a><a href="/pmc/articles/PMC10703611" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35432323">Macrophage Subsets and Death Are Responsible for Atherosclerotic Plaque Formation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li H,
|
||
Cao Z,
|
||
Wang L,
|
||
Liu C,
|
||
Lin H,
|
||
Tang Y,
|
||
Yao P</span><br />
|
||
<span class="medgenPMjournal">Front Immunol</span>
|
||
2022;13:843712.
|
||
Epub 2022 Mar 30
|
||
doi: 10.3389/fimmu.2022.843712.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35432323" target="_blank">35432323</a><a href="/pmc/articles/PMC9007036" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35038214">Burden of central nervous system complications in sickle cell disease: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee S,
|
||
Lucas S,
|
||
Proudman D,
|
||
Nellesen D,
|
||
Paulose J,
|
||
Sheehan VA</span><br />
|
||
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
|
||
2022 Apr;69(4):e29493.
|
||
Epub 2022 Jan 17
|
||
doi: 10.1002/pbc.29493.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35038214" target="_blank">35038214</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34028001">Serum or plasma ferritin concentration as an index of iron deficiency and overload.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Garcia-Casal MN,
|
||
Pasricha SR,
|
||
Martinez RX,
|
||
Lopez-Perez L,
|
||
Peña-Rosas JP</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2021 May 24;5(5):CD011817.
|
||
doi: 10.1002/14651858.CD011817.pub2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34028001" target="_blank">34028001</a><a href="/pmc/articles/PMC8142307" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26561626">Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Peyrin-Biroulet L,
|
||
Williet N,
|
||
Cacoub P</span><br />
|
||
<span class="medgenPMjournal">Am J Clin Nutr</span>
|
||
2015 Dec;102(6):1585-94.
|
||
Epub 2015 Nov 11
|
||
doi: 10.3945/ajcn.114.103366.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26561626" target="_blank">26561626</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Iron%20Overload%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (106)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22iron%20overload%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Iron%20Overload%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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