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<meta name="keywords" content="C0279606, childhood carcinoma of liver cell, childhood carcinoma of the liver cell, childhood hepatocellular carcinoma, childhood hepatoma, childhood liver cell carcinoma, childhood-onset hcc, childhood-onset hcc (hepatocellular carcinoma), childhood-onset hepatocellular carcinoma, hepatocellular carcinoma, childhood onset, neoplastic process, paediatric carcinoma of liver cell, paediatric carcinoma of the liver cell, paediatric hcc, paediatric hepatoma, paediatric liver cell carcinoma, pediatric carcinoma of liver cell, pediatric carcinoma of the liver cell, pediatric hcc, pediatric hcc (hepatocellular carcinoma), pediatric hepatocellular carcinoma, pediatric hepatoma, pediatric liver cell carcinoma, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A rare aggressive malignant hepatic tumour arising from the hepatocytes. It develops mainly in children over 10 years of age, either in a cirrhotic background, or more commonly in a non-cirrhotic background. The main presenting manifestations are abdominal mass with pain, swelling and discomfort, weight loss, and anorexia. Splenomegaly, nausea, vomiting and jaundice are less commonly observed. Metastases to the mediastinal lymph nodes, lungs, brain and bone marrow are common in advanced disease May be associated with congenital diseases such as biliary atresia. The Wnt/beta-catenin pathway is frequently activated via stabilising mutations in beta-catenin: some patients have been found to have mutations in the CTNNB1 (3p21) and MET (7q31) genes. TP53 (17p13.1) gene and the TERT promoter are mutated in 25-30% and 60% of cases respectively." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
|
||
UID=75999
|
||
ConceptID=C0279606
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Pediatric hepatocellular carcinoma</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>75999</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0279606</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Childhood hepatocellular carcinoma</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Pediatric hepatocellular carcinoma (1208349005); Childhood-onset hepatocellular carcinoma (1208349005); Childhood-onset HCC (hepatocellular carcinoma) (1208349005); Pediatric HCC (hepatocellular carcinoma) (1208349005)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information.">CN307044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0018055" target="_blank">MONDO:0018055</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=33402">ORPHA33402</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">A rare aggressive malignant hepatic tumour arising from the hepatocytes. It develops mainly in children over 10 years of age, either in a cirrhotic background, or more commonly in a non-cirrhotic background. The main presenting manifestations are abdominal mass with pain, swelling and discomfort, weight loss, and anorexia. Splenomegaly, nausea, vomiting and jaundice are less commonly observed. Metastases to the mediastinal lymph nodes, lungs, brain and bone marrow are common in advanced disease May be associated with congenital diseases such as biliary atresia. The Wnt/beta-catenin pathway is frequently activated via stabilising mutations in beta-catenin: some patients have been found to have mutations in the CTNNB1 (3p21) and MET (7q31) genes. TP53 (17p13.1) gene and the TERT promoter are mutated in 25-30% and 60% of cases respectively. [from <a title="US Edition of SNOMED CT" href="http://www.nlm.nih.gov/research/umls/Snomed/us_edition.html" class="defSource" target="_blank">SNOMEDCT_US</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0279606[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=75999">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=75999" ref="ncbi_uid=75999">V</a></span></span><span class="TLline">Pediatric hepatocellular carcinoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/235364" ref="tree=MeSH" title="MedGen record for Neoplasm by Special Category">Neoplasm by Special Category</a></span><ul><li><span class="TLline"><a href="/medgen/237153" ref="tree=MeSH" title="MedGen record for Childhood neoplasm">Childhood neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/234130" ref="tree=MeSH" title="MedGen record for Childhood Liver Neoplasm">Childhood Liver Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/424855" ref="tree=MeSH" title="MedGen record for Childhood Malignant Liver Neoplasm">Childhood Malignant Liver Neoplasm</a></span><ul><li><span class="matched_ds">Pediatric hepatocellular carcinoma</span><ul><li><span class="TLline"><a href="/medgen/235093" ref="tree=MeSH" title="MedGen record for Recurrent Childhood Hepatocellular Carcinoma">Recurrent Childhood Hepatocellular Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1619042" ref="tree=MeSH" title="MedGen record for Stage I Childhood Hepatocellular Carcinoma AJCC v6 and v7">Stage I Childhood Hepatocellular Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1616162" ref="tree=MeSH" title="MedGen record for Stage II Childhood Hepatocellular Carcinoma AJCC v6 and v7">Stage II Childhood Hepatocellular Carcinoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/75856" ref="tree=MeSH" title="MedGen record for Stage III Childhood Hepatocellular Carcinoma AJCC v7">Stage III Childhood Hepatocellular Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1620235" ref="tree=MeSH" title="MedGen record for Stage IV Childhood Hepatocellular Carcinoma AJCC v7">Stage IV Childhood Hepatocellular Carcinoma AJCC v7</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32602829">Pediatric Hepatoblastoma, Hepatocellular Carcinoma, and Other Hepatic Neoplasms: Consensus Imaging Recommendations from American College of Radiology Pediatric Liver Reporting and Data System (LI-RADS) Working Group.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schooler GR,
|
||
Squires JH,
|
||
Alazraki A,
|
||
Chavhan GB,
|
||
Chernyak V,
|
||
Davis JT,
|
||
Khanna G,
|
||
Krishnamurthy R,
|
||
Lungren MP,
|
||
Masand PM,
|
||
Podberesky DJ,
|
||
Sirlin CB,
|
||
Towbin AJ</span><br />
|
||
<span class="medgenPMjournal">Radiology</span>
|
||
2020 Sep;296(3):493-497.
|
||
Epub 2020 Jun 30
|
||
doi: 10.1148/radiol.2020200751.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32602829" target="_blank">32602829</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30259629">Is hepatocellular carcinoma the same disease in children and adults? Comparison of histology, molecular background, and treatment in pediatric and adult patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Weeda VB,
|
||
Aronson DC,
|
||
Verheij J,
|
||
Lamers WH</span><br />
|
||
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
|
||
2019 Feb;66(2):e27475.
|
||
Epub 2018 Sep 26
|
||
doi: 10.1002/pbc.27475.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30259629" target="_blank">30259629</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29427028">2017 PRETEXT: radiologic staging system for primary hepatic malignancies of childhood revised for the Paediatric Hepatic International Tumour Trial (PHITT).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Towbin AJ,
|
||
Meyers RL,
|
||
Woodley H,
|
||
Miyazaki O,
|
||
Weldon CB,
|
||
Morland B,
|
||
Hiyama E,
|
||
Czauderna P,
|
||
Roebuck DJ,
|
||
Tiao GM</span><br />
|
||
<span class="medgenPMjournal">Pediatr Radiol</span>
|
||
2018 Apr;48(4):536-554.
|
||
Epub 2018 Feb 9
|
||
doi: 10.1007/s00247-018-4078-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29427028" target="_blank">29427028</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22pediatric%20hepatocellular%20carcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (3)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36513143">State of the art and perspectives in pediatric hepatocellular carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Digiacomo G,
|
||
Serra RP,
|
||
Turrini E,
|
||
Tiri A,
|
||
Cavazzoni A,
|
||
Alfieri R,
|
||
Bertolini P</span><br />
|
||
<span class="medgenPMjournal">Biochem Pharmacol</span>
|
||
2023 Jan;207:115373.
|
||
Epub 2022 Dec 10
|
||
doi: 10.1016/j.bcp.2022.115373.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36513143" target="_blank">36513143</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33751174">Imaging and clinical features of pediatric hepatocellular carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Arias GA,
|
||
Siddiqui I,
|
||
Navarro OM,
|
||
Shaikh F,
|
||
Sayed BA,
|
||
Chavhan GB</span><br />
|
||
<span class="medgenPMjournal">Pediatr Radiol</span>
|
||
2021 Jul;51(8):1339-1347.
|
||
Epub 2021 Mar 10
|
||
doi: 10.1007/s00247-021-04989-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33751174" target="_blank">33751174</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31554479">Hepatoblastoma and Pediatric Hepatocellular Carcinoma: An Update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ranganathan S,
|
||
Lopez-Terrada D,
|
||
Alaggio R</span><br />
|
||
<span class="medgenPMjournal">Pediatr Dev Pathol</span>
|
||
2020 Mar-Apr;23(2):79-95.
|
||
Epub 2019 Sep 25
|
||
doi: 10.1177/1093526619875228.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31554479" target="_blank">31554479</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30254403">Pediatric hepatocellular carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khanna R,
|
||
Verma SK</span><br />
|
||
<span class="medgenPMjournal">World J Gastroenterol</span>
|
||
2018 Sep 21;24(35):3980-3999.
|
||
doi: 10.3748/wjg.v24.i35.3980.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30254403" target="_blank">30254403</a><a href="/pmc/articles/PMC6148423" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29427028">2017 PRETEXT: radiologic staging system for primary hepatic malignancies of childhood revised for the Paediatric Hepatic International Tumour Trial (PHITT).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Towbin AJ,
|
||
Meyers RL,
|
||
Woodley H,
|
||
Miyazaki O,
|
||
Weldon CB,
|
||
Morland B,
|
||
Hiyama E,
|
||
Czauderna P,
|
||
Roebuck DJ,
|
||
Tiao GM</span><br />
|
||
<span class="medgenPMjournal">Pediatr Radiol</span>
|
||
2018 Apr;48(4):536-554.
|
||
Epub 2018 Feb 9
|
||
doi: 10.1007/s00247-018-4078-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29427028" target="_blank">29427028</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pediatric%20hepatocellular%20carcinoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (20)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36513143">State of the art and perspectives in pediatric hepatocellular carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Digiacomo G,
|
||
Serra RP,
|
||
Turrini E,
|
||
Tiri A,
|
||
Cavazzoni A,
|
||
Alfieri R,
|
||
Bertolini P</span><br />
|
||
<span class="medgenPMjournal">Biochem Pharmacol</span>
|
||
2023 Jan;207:115373.
|
||
Epub 2022 Dec 10
|
||
doi: 10.1016/j.bcp.2022.115373.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36513143" target="_blank">36513143</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32856229">Pediatric Hepatocellular Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Varol Fİ</span><br />
|
||
<span class="medgenPMjournal">J Gastrointest Cancer</span>
|
||
2020 Dec;51(4):1169-1175.
|
||
doi: 10.1007/s12029-020-00494-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32856229" target="_blank">32856229</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32307899">Clinical heterogeneity of pediatric hepatocellular carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">D'Souza AM,
|
||
Towbin AJ,
|
||
Gupta A,
|
||
Alonso M,
|
||
Nathan JD,
|
||
Bondoc A,
|
||
Tiao G,
|
||
Geller JI</span><br />
|
||
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
|
||
2020 Jun;67(6):e28307.
|
||
Epub 2020 Apr 19
|
||
doi: 10.1002/pbc.28307.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32307899" target="_blank">32307899</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31554479">Hepatoblastoma and Pediatric Hepatocellular Carcinoma: An Update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ranganathan S,
|
||
Lopez-Terrada D,
|
||
Alaggio R</span><br />
|
||
<span class="medgenPMjournal">Pediatr Dev Pathol</span>
|
||
2020 Mar-Apr;23(2):79-95.
|
||
Epub 2019 Sep 25
|
||
doi: 10.1177/1093526619875228.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31554479" target="_blank">31554479</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23212597">Radioembolisation for treatment of pediatric hepatocellular carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hawkins CM,
|
||
Kukreja K,
|
||
Geller JI,
|
||
Schatzman C,
|
||
Ristagno R</span><br />
|
||
<span class="medgenPMjournal">Pediatr Radiol</span>
|
||
2013 Jul;43(7):876-81.
|
||
Epub 2012 Dec 5
|
||
doi: 10.1007/s00247-012-2568-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23212597" target="_blank">23212597</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pediatric%20hepatocellular%20carcinoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (19)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36513143">State of the art and perspectives in pediatric hepatocellular carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Digiacomo G,
|
||
Serra RP,
|
||
Turrini E,
|
||
Tiri A,
|
||
Cavazzoni A,
|
||
Alfieri R,
|
||
Bertolini P</span><br />
|
||
<span class="medgenPMjournal">Biochem Pharmacol</span>
|
||
2023 Jan;207:115373.
|
||
Epub 2022 Dec 10
|
||
doi: 10.1016/j.bcp.2022.115373.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36513143" target="_blank">36513143</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34060723">Pharmacokinetically guided dosing of oral sorafenib in pediatric hepatocellular carcinoma: A simulation study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Panetta JC,
|
||
Campagne O,
|
||
Gartrell J,
|
||
Furman W,
|
||
Stewart CF</span><br />
|
||
<span class="medgenPMjournal">Clin Transl Sci</span>
|
||
2021 Nov;14(6):2152-2160.
|
||
Epub 2021 Jun 1
|
||
doi: 10.1111/cts.13069.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34060723" target="_blank">34060723</a><a href="/pmc/articles/PMC8604221" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32856229">Pediatric Hepatocellular Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Varol Fİ</span><br />
|
||
<span class="medgenPMjournal">J Gastrointest Cancer</span>
|
||
2020 Dec;51(4):1169-1175.
|
||
doi: 10.1007/s12029-020-00494-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32856229" target="_blank">32856229</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30254403">Pediatric hepatocellular carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khanna R,
|
||
Verma SK</span><br />
|
||
<span class="medgenPMjournal">World J Gastroenterol</span>
|
||
2018 Sep 21;24(35):3980-3999.
|
||
doi: 10.3748/wjg.v24.i35.3980.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30254403" target="_blank">30254403</a><a href="/pmc/articles/PMC6148423" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29427028">2017 PRETEXT: radiologic staging system for primary hepatic malignancies of childhood revised for the Paediatric Hepatic International Tumour Trial (PHITT).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Towbin AJ,
|
||
Meyers RL,
|
||
Woodley H,
|
||
Miyazaki O,
|
||
Weldon CB,
|
||
Morland B,
|
||
Hiyama E,
|
||
Czauderna P,
|
||
Roebuck DJ,
|
||
Tiao GM</span><br />
|
||
<span class="medgenPMjournal">Pediatr Radiol</span>
|
||
2018 Apr;48(4):536-554.
|
||
Epub 2018 Feb 9
|
||
doi: 10.1007/s00247-018-4078-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29427028" target="_blank">29427028</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pediatric%20hepatocellular%20carcinoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (15)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36513143">State of the art and perspectives in pediatric hepatocellular carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Digiacomo G,
|
||
Serra RP,
|
||
Turrini E,
|
||
Tiri A,
|
||
Cavazzoni A,
|
||
Alfieri R,
|
||
Bertolini P</span><br />
|
||
<span class="medgenPMjournal">Biochem Pharmacol</span>
|
||
2023 Jan;207:115373.
|
||
Epub 2022 Dec 10
|
||
doi: 10.1016/j.bcp.2022.115373.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36513143" target="_blank">36513143</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32856229">Pediatric Hepatocellular Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Varol Fİ</span><br />
|
||
<span class="medgenPMjournal">J Gastrointest Cancer</span>
|
||
2020 Dec;51(4):1169-1175.
|
||
doi: 10.1007/s12029-020-00494-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32856229" target="_blank">32856229</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32307899">Clinical heterogeneity of pediatric hepatocellular carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">D'Souza AM,
|
||
Towbin AJ,
|
||
Gupta A,
|
||
Alonso M,
|
||
Nathan JD,
|
||
Bondoc A,
|
||
Tiao G,
|
||
Geller JI</span><br />
|
||
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
|
||
2020 Jun;67(6):e28307.
|
||
Epub 2020 Apr 19
|
||
doi: 10.1002/pbc.28307.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32307899" target="_blank">32307899</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31554479">Hepatoblastoma and Pediatric Hepatocellular Carcinoma: An Update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ranganathan S,
|
||
Lopez-Terrada D,
|
||
Alaggio R</span><br />
|
||
<span class="medgenPMjournal">Pediatr Dev Pathol</span>
|
||
2020 Mar-Apr;23(2):79-95.
|
||
Epub 2019 Sep 25
|
||
doi: 10.1177/1093526619875228.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31554479" target="_blank">31554479</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30254403">Pediatric hepatocellular carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khanna R,
|
||
Verma SK</span><br />
|
||
<span class="medgenPMjournal">World J Gastroenterol</span>
|
||
2018 Sep 21;24(35):3980-3999.
|
||
doi: 10.3748/wjg.v24.i35.3980.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30254403" target="_blank">30254403</a><a href="/pmc/articles/PMC6148423" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pediatric%20hepatocellular%20carcinoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (18)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39523995">Outcomes of Pediatric Hepatocellular Carcinoma: A Single-Center Experience With Resection Versus Transplantation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Medio P,
|
||
Matesanz S,
|
||
Margareto M,
|
||
Ostos P,
|
||
Palomo C,
|
||
Hernández Oliveros F,
|
||
Moreno AA</span><br />
|
||
<span class="medgenPMjournal">Pediatr Transplant</span>
|
||
2024 Dec;28(8):e14882.
|
||
doi: 10.1111/petr.14882.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39523995" target="_blank">39523995</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35544373">Imaging Features of Hepatocellular Carcinoma in Children With and Without Underlying Risk Factors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rees MA,
|
||
Schooler GR,
|
||
Chavhan GB,
|
||
Towbin AJ,
|
||
Alazraki AL,
|
||
Squires JH,
|
||
Fraum TJ,
|
||
Zhang C,
|
||
Khanna G</span><br />
|
||
<span class="medgenPMjournal">AJR Am J Roentgenol</span>
|
||
2022 Oct;219(4):647-654.
|
||
Epub 2022 May 11
|
||
doi: 10.2214/AJR.22.27600.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35544373" target="_blank">35544373</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34060723">Pharmacokinetically guided dosing of oral sorafenib in pediatric hepatocellular carcinoma: A simulation study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Panetta JC,
|
||
Campagne O,
|
||
Gartrell J,
|
||
Furman W,
|
||
Stewart CF</span><br />
|
||
<span class="medgenPMjournal">Clin Transl Sci</span>
|
||
2021 Nov;14(6):2152-2160.
|
||
Epub 2021 Jun 1
|
||
doi: 10.1111/cts.13069.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34060723" target="_blank">34060723</a><a href="/pmc/articles/PMC8604221" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33620289">Diagnostic Performance of LI-RADS Version 2018 for Evaluation of Pediatric Hepatocellular Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khanna G,
|
||
Chavhan GB,
|
||
Schooler GR,
|
||
Fraum TJ,
|
||
Alazraki AL,
|
||
Squires JH,
|
||
Salter A,
|
||
Podberesky DJ,
|
||
Towbin AJ</span><br />
|
||
<span class="medgenPMjournal">Radiology</span>
|
||
2021 Apr;299(1):190-199.
|
||
Epub 2021 Feb 23
|
||
doi: 10.1148/radiol.2021203559.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33620289" target="_blank">33620289</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32660779">Surgical management of pediatric hepatocellular carcinoma: An analysis of the National Cancer Database.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ziogas IA,
|
||
Benedetti DJ,
|
||
Matsuoka LK,
|
||
Izzy M,
|
||
Rauf MA,
|
||
Pai AK,
|
||
Bailey CE,
|
||
Alexopoulos SP</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Surg</span>
|
||
2021 Apr;56(4):772-777.
|
||
Epub 2020 Jun 18
|
||
doi: 10.1016/j.jpedsurg.2020.06.013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32660779" target="_blank">32660779</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pediatric%20hepatocellular%20carcinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (10)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0279606%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (1)</a></li>
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