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<meta name="keywords" content="C0278804, adenocarcinoma of duodenum, adenocarcinoma of the duodenum, duodenal adenocarcinoma, duodenal cancer, duodenum adenocarcinoma, neoplastic process, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A malignant epithelial tumor with a glandular organization that originates in the duodenum." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Duodenal adenocarcinoma (Concept Id: C0278804)
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<!--
UID=82985
ConceptID=C0278804
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Duodenal adenocarcinoma</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82985</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0278804</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Adenocarcinoma of duodenum; Adenocarcinoma of Duodenum; adenocarcinoma of duodenum; Adenocarcinoma of the Duodenum; adenocarcinoma of the duodenum; Duodenal Adenocarcinoma; duodenal adenocarcinoma; Duodenal cancer; duodenum adenocarcinoma</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Adenocarcinoma of duodenum (408644002)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0006771">HP:0006771</a></td></tr>
<tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0006186" target="_blank">MONDO:0006186</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">A malignant epithelial tumor with a glandular organization that originates in the duodenum. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Duodenal adenocarcinoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/277963" ref="tree=MeSH" title="MedGen record for Epithelial neoplasm">Epithelial neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/2867" ref="tree=MeSH" title="MedGen record for Carcinoma">Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/122" ref="tree=MeSH" title="MedGen record for Adenocarcinoma">Adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/82984" ref="tree=MeSH" title="MedGen record for Adenocarcinoma of the small intestine">Adenocarcinoma of the small intestine</a></span><ul><li><span class="matched_ds">Duodenal adenocarcinoma</span><ul><li><span class="TLline"><a href="/medgen/233847" ref="tree=MeSH" title="MedGen record for Periampullary adenocarcinoma">Periampullary adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1746792" ref="tree=MeSH" title="MedGen record for Resectable Periampullary Adenocarcinoma">Resectable Periampullary Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1717157" ref="tree=MeSH" title="MedGen record for Unresectable Periampullary Adenocarcinoma">Unresectable Periampullary Adenocarcinoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_87518"><div><strong>Juvenile polyposis syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>87518</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0345893</a></dd><dt><span class="dotprefix"></span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
<div class="spaceAbove">Juvenile polyposis syndrome (JPS) is characterized by predisposition to hamartomatous polyps in the gastrointestinal (GI) tract, specifically in the stomach, small intestine, colon, and rectum. The term "juvenile" refers to the type of polyp rather than to the age of onset of polyps. Most individuals with JPS have some polyps by age 20 years; some may have only four or five polyps over their lifetime, whereas others in the same family may have more than 100. If the polyps are left untreated, they may cause bleeding and anemia. Most juvenile polyps are benign; however, malignant transformation can occur. Risk for GI cancers ranges from 11% to 86%. Most of this increased risk is attributed to colon cancer, but cancers of the stomach, upper GI tract, and pancreas have also been reported. A combined syndrome of JPS and hereditary hemorrhagic telangiectasia (HHT) is present in most individuals with an SMAD4 pathogenic variant.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/87518">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_231157"><div><strong>Muir-Torré syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>231157</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1321489</a></dd><dt><span class="dotprefix"></span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
<div class="spaceAbove">Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/231157">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_398651"><div><strong>Familial adenomatous polyposis 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>398651</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C2713442</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">APC-associated polyposis conditions include (classic or attenuated) familial adenomatous polyposis (FAP) and gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). FAP is a colorectal cancer (CRC) predisposition syndrome that can manifest in either classic or attenuated form. Classic FAP is characterized by hundreds to thousands of adenomatous colonic polyps, beginning on average at age 16 years (range 7-36 years). For those with the classic form of FAP, 95% of individuals have polyps by age 35 years; CRC is inevitable without colectomy. The mean age of CRC diagnosis in untreated individuals is 39 years (range 34-43 years). The attenuated form is characterized by multiple colonic polyps (average of 30), more proximally located polyps, and a diagnosis of CRC at a later age than in classic FAP. For those with an attenuated form, there is a 70% lifetime risk of CRC and the mean age of diagnosis is 50-55 years. Extracolonic manifestations are variably present and include polyps of the stomach and duodenum, osteomas, dental abnormalities, congenital hypertrophy of the retinal pigment epithelium (CHRPE), benign cutaneous lesions, desmoid tumors, adrenal masses, and other associated cancers. GAPPS is characterized by proximal gastric polyposis, increased risk of gastric adenocarcinoma, and no duodenal or colonic involvement in most individuals reported.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/398651">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_902388"><div><strong>Familial adenomatous polyposis 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>902388</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4225157</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">NTHL1 tumor syndrome is characterized by an increased lifetime risk for colorectal cancer (CRC), breast cancer, and colorectal polyposis. Colorectal polyps can be adenomatous, hyperplastic, and/or sessile serrated. Duodenal polyposis has also been reported. Additional cancers reported in individuals with NTHL1 tumor syndrome include endometrial cancer, cervical cancer, urothelial carcinoma of the bladder, meningiomas, unspecified brain tumors, basal cell carcinomas, head and neck squamous cell carcinomas, and hematologic malignancies. The cumulative lifetime risk of developing extracolonic cancer by age 60 years has been estimated at 35% to 78%.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/902388">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_398651" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial adenomatous polyposis 1</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_902388" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial adenomatous polyposis 3</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_87518" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Juvenile polyposis syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_231157" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Muir-Torré syndrome</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/37500390">Radiotherapy in the management of rare gastrointestinal cancers: A systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bellefkih FZ,
Benchakroun N,
Lalya I,
Amaoui B,
El Kacemi H,
Acharki A,
El Hfid M,
El Mazghi A,
Chekrine T,
Bouchbika Z,
Jouhadi H,
Sahraoui S,
Tawfiq N,
Michalet M</span><br />
<span class="medgenPMjournal">Cancer Radiother</span>
2023 Sep;27(6-7):622-637.
Epub 2023 Jul 25
doi: 10.1016/j.canrad.2023.06.010.
<span class="bold">PMID: </span><a href="/pubmed/37500390" target="_blank">37500390</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35135724">Treatment and overall survival of four types of non-metastatic periampullary cancer: nationwide population-based cohort study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">de Jong EJM,
van der Geest LG,
Besselink MG,
Bouwense SAW,
Buijsen J,
Dejong CHC,
Koerkamp BG,
Heij LR,
de Hingh IHJT,
Hoge C,
Kazemier G,
van Laarhoven HWM,
de Meijer VE,
Stommel MWJ,
Tjan-Heijnen VCG,
Valkenburg-van Iersel LBJ,
Wilmink JW,
Geurts SME,
de Vos-Geelen J;
Dutch Pancreatic Cancer Group</span><br />
<span class="medgenPMjournal">HPB (Oxford)</span>
2022 Sep;24(9):1433-1442.
Epub 2022 Jan 23
doi: 10.1016/j.hpb.2022.01.009.
<span class="bold">PMID: </span><a href="/pubmed/35135724" target="_blank">35135724</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29946997">Outcomes and Treatment Options for Duodenal Adenocarcinoma: A Systematic Review and Meta-Analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Meijer LL,
Alberga AJ,
de Bakker JK,
van der Vliet HJ,
Le Large TYS,
van Grieken NCT,
de Vries R,
Daams F,
Zonderhuis BM,
Kazemier G</span><br />
<span class="medgenPMjournal">Ann Surg Oncol</span>
2018 Sep;25(9):2681-2692.
Epub 2018 Jun 26
doi: 10.1245/s10434-018-6567-6.
<span class="bold">PMID: </span><a href="/pubmed/29946997" target="_blank">29946997</a><a href="/pmc/articles/PMC6097725" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22duodenal%20adenocarcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (22)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/39261238">Clinicopathologic features and surgery-related outcomes of duodenal adenocarcinoma: A multicenter retrospective study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Xiao Q,
Wu X,
Yuan C,
Gu Z,
Tang X,
Meng F,
Wang D,
Lang R,
Zhai G,
Tian X,
Zhang Y,
Zhao E,
Zhao X,
Cao F,
Xu J,
Xing Y,
Wang C,
Zhang J</span><br />
<span class="medgenPMjournal">Surgery</span>
2024 Dec;176(6):1745-1753.
Epub 2024 Sep 10
doi: 10.1016/j.surg.2024.08.007.
<span class="bold">PMID: </span><a href="/pubmed/39261238" target="_blank">39261238</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37804876">Inverted nonampullary duodenal adenocarcinoma treated with underwater EMR.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Matsueda K,
Kawano S,
Tanaka T</span><br />
<span class="medgenPMjournal">Gastrointest Endosc</span>
2024 Mar;99(3):465-466.
Epub 2023 Oct 6
doi: 10.1016/j.gie.2023.10.004.
<span class="bold">PMID: </span><a href="/pubmed/37804876" target="_blank">37804876</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35421045">Malignancies in Deceased Organ Donors: The Spanish Experience.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mahíllo B,
Martín S,
Molano E,
Navarro A,
Castro P,
Pont T,
Andrés A,
Galán J,
López M,
Oliver E,
Martínez A,
Mosteiro F,
Roque R,
Pérez-Redondo M,
Cid-Cumplido M,
Ballesteros MA,
Daga D,
Quindós B,
Sancho M,
Royo-Villanova M,
Bernabé E,
Muñoz R,
Chacón JI,
Coll E,
Domínguez-Gil B</span><br />
<span class="medgenPMjournal">Transplantation</span>
2022 Sep 1;106(9):1814-1823.
Epub 2022 Apr 1
doi: 10.1097/TP.0000000000004117.
<span class="bold">PMID: </span><a href="/pubmed/35421045" target="_blank">35421045</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35325501">Donor-derived duodenal adenocarcinoma of a bladder-drained pancreas allograft.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Isaacson D,
Steggerda J,
Xue Y,
Wren J,
Javeed Ansari M,
Auffenberg GB,
Katariya N</span><br />
<span class="medgenPMjournal">Am J Transplant</span>
2022 Sep;22(9):2265-2268.
Epub 2022 Apr 2
doi: 10.1111/ajt.17042.
<span class="bold">PMID: </span><a href="/pubmed/35325501" target="_blank">35325501</a><a href="/pmc/articles/PMC9543768" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25310836">Extra-ampullary duodenal adenocarcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ushiku T,
Arnason T,
Fukayama M,
Lauwers GY</span><br />
<span class="medgenPMjournal">Am J Surg Pathol</span>
2014 Nov;38(11):1484-93.
doi: 10.1097/PAS.0000000000000278.
<span class="bold">PMID: </span><a href="/pubmed/25310836" target="_blank">25310836</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Duodenal%20adenocarcinoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (164)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/35487298">Duodenal adenocarcinoma presenting as duodenal cystic dystrophy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Durham K,
Zhang X,
Bosch DE,
Ashat M</span><br />
<span class="medgenPMjournal">Gastrointest Endosc</span>
2022 Aug;96(2):378-380.
Epub 2022 Apr 26
doi: 10.1016/j.gie.2022.04.021.
<span class="bold">PMID: </span><a href="/pubmed/35487298" target="_blank">35487298</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35421045">Malignancies in Deceased Organ Donors: The Spanish Experience.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mahíllo B,
Martín S,
Molano E,
Navarro A,
Castro P,
Pont T,
Andrés A,
Galán J,
López M,
Oliver E,
Martínez A,
Mosteiro F,
Roque R,
Pérez-Redondo M,
Cid-Cumplido M,
Ballesteros MA,
Daga D,
Quindós B,
Sancho M,
Royo-Villanova M,
Bernabé E,
Muñoz R,
Chacón JI,
Coll E,
Domínguez-Gil B</span><br />
<span class="medgenPMjournal">Transplantation</span>
2022 Sep 1;106(9):1814-1823.
Epub 2022 Apr 1
doi: 10.1097/TP.0000000000004117.
<span class="bold">PMID: </span><a href="/pubmed/35421045" target="_blank">35421045</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27600057">Anisakidosis: a fortuitous mimicker of gastrointestinal malignancy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Khan MQ,
Williams J</span><br />
<span class="medgenPMjournal">BMJ Case Rep</span>
2016 Sep 6;2016
doi: 10.1136/bcr-2016-216164.
<span class="bold">PMID: </span><a href="/pubmed/27600057" target="_blank">27600057</a><a href="/pmc/articles/PMC5020723" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19267092">Primary duodenal adenocarcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Solej M,
D'Amico S,
Brondino G,
Ferronato M,
Nano M</span><br />
<span class="medgenPMjournal">Tumori</span>
2008 Nov-Dec;94(6):779-86.
doi: 10.1177/030089160809400601.
<span class="bold">PMID: </span><a href="/pubmed/19267092" target="_blank">19267092</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15293686">Duodenal adenocarcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Peersman B,
Schepens E,
De Schepper AM,
Wassenaar H</span><br />
<span class="medgenPMjournal">JBR-BTR</span>
2004 May-Jun;87(3):148-9.
<span class="bold">PMID: </span><a href="/pubmed/15293686" target="_blank">15293686</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Duodenal%20adenocarcinoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (138)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/37952021">Neoadjuvant Therapy for Duodenal and Ampullary Adenocarcinoma: A Systematic Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang C,
Lizalek JM,
Dougherty C,
Westmark DM,
Klute KA,
Reames BN</span><br />
<span class="medgenPMjournal">Ann Surg Oncol</span>
2024 Feb;31(2):792-803.
Epub 2023 Nov 11
doi: 10.1245/s10434-023-14531-y.
<span class="bold">PMID: </span><a href="/pubmed/37952021" target="_blank">37952021</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37088148">A possible role for ketorolac in the management of increased biliary drain output.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yu AT,
Khajoueinejad N,
Gross A,
Golas BJ,
Cohen NA</span><br />
<span class="medgenPMjournal">Clin Res Hepatol Gastroenterol</span>
2023 May;47(6):102128.
Epub 2023 Apr 23
doi: 10.1016/j.clinre.2023.102128.
<span class="bold">PMID: </span><a href="/pubmed/37088148" target="_blank">37088148</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35421045">Malignancies in Deceased Organ Donors: The Spanish Experience.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mahíllo B,
Martín S,
Molano E,
Navarro A,
Castro P,
Pont T,
Andrés A,
Galán J,
López M,
Oliver E,
Martínez A,
Mosteiro F,
Roque R,
Pérez-Redondo M,
Cid-Cumplido M,
Ballesteros MA,
Daga D,
Quindós B,
Sancho M,
Royo-Villanova M,
Bernabé E,
Muñoz R,
Chacón JI,
Coll E,
Domínguez-Gil B</span><br />
<span class="medgenPMjournal">Transplantation</span>
2022 Sep 1;106(9):1814-1823.
Epub 2022 Apr 1
doi: 10.1097/TP.0000000000004117.
<span class="bold">PMID: </span><a href="/pubmed/35421045" target="_blank">35421045</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35325501">Donor-derived duodenal adenocarcinoma of a bladder-drained pancreas allograft.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Isaacson D,
Steggerda J,
Xue Y,
Wren J,
Javeed Ansari M,
Auffenberg GB,
Katariya N</span><br />
<span class="medgenPMjournal">Am J Transplant</span>
2022 Sep;22(9):2265-2268.
Epub 2022 Apr 2
doi: 10.1111/ajt.17042.
<span class="bold">PMID: </span><a href="/pubmed/35325501" target="_blank">35325501</a><a href="/pmc/articles/PMC9543768" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27600057">Anisakidosis: a fortuitous mimicker of gastrointestinal malignancy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Khan MQ,
Williams J</span><br />
<span class="medgenPMjournal">BMJ Case Rep</span>
2016 Sep 6;2016
doi: 10.1136/bcr-2016-216164.
<span class="bold">PMID: </span><a href="/pubmed/27600057" target="_blank">27600057</a><a href="/pmc/articles/PMC5020723" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Duodenal%20adenocarcinoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (58)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/39261238">Clinicopathologic features and surgery-related outcomes of duodenal adenocarcinoma: A multicenter retrospective study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Xiao Q,
Wu X,
Yuan C,
Gu Z,
Tang X,
Meng F,
Wang D,
Lang R,
Zhai G,
Tian X,
Zhang Y,
Zhao E,
Zhao X,
Cao F,
Xu J,
Xing Y,
Wang C,
Zhang J</span><br />
<span class="medgenPMjournal">Surgery</span>
2024 Dec;176(6):1745-1753.
Epub 2024 Sep 10
doi: 10.1016/j.surg.2024.08.007.
<span class="bold">PMID: </span><a href="/pubmed/39261238" target="_blank">39261238</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34012147">Surgical treatment of duodenal adenocarcinoma: ampullary vs. non-ampullary, short- and long-term outcomes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tesarikova J,
Skalicky P,
Kurfurstova D,
Svebisova H,
Urban O,
Falt P,
Zapletalova J,
Klos D,
Lovecek M</span><br />
<span class="medgenPMjournal">Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub</span>
2022 Sep;166(3):290-296.
Epub 2021 May 11
doi: 10.5507/bp.2021.028.
<span class="bold">PMID: </span><a href="/pubmed/34012147" target="_blank">34012147</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34528570">A case of duodenal adenocarcinoma treated with primary chemoradiation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Manur JG,
Jain HM</span><br />
<span class="medgenPMjournal">J Cancer Res Ther</span>
2021 Jul-Sep;17(4):1101-1103.
doi: 10.4103/jcrt.JCRT_695_19.
<span class="bold">PMID: </span><a href="/pubmed/34528570" target="_blank">34528570</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29946997">Outcomes and Treatment Options for Duodenal Adenocarcinoma: A Systematic Review and Meta-Analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Meijer LL,
Alberga AJ,
de Bakker JK,
van der Vliet HJ,
Le Large TYS,
van Grieken NCT,
de Vries R,
Daams F,
Zonderhuis BM,
Kazemier G</span><br />
<span class="medgenPMjournal">Ann Surg Oncol</span>
2018 Sep;25(9):2681-2692.
Epub 2018 Jun 26
doi: 10.1245/s10434-018-6567-6.
<span class="bold">PMID: </span><a href="/pubmed/29946997" target="_blank">29946997</a><a href="/pmc/articles/PMC6097725" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19267092">Primary duodenal adenocarcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Solej M,
D'Amico S,
Brondino G,
Ferronato M,
Nano M</span><br />
<span class="medgenPMjournal">Tumori</span>
2008 Nov-Dec;94(6):779-86.
doi: 10.1177/030089160809400601.
<span class="bold">PMID: </span><a href="/pubmed/19267092" target="_blank">19267092</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Duodenal%20adenocarcinoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (148)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/39261238">Clinicopathologic features and surgery-related outcomes of duodenal adenocarcinoma: A multicenter retrospective study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Xiao Q,
Wu X,
Yuan C,
Gu Z,
Tang X,
Meng F,
Wang D,
Lang R,
Zhai G,
Tian X,
Zhang Y,
Zhao E,
Zhao X,
Cao F,
Xu J,
Xing Y,
Wang C,
Zhang J</span><br />
<span class="medgenPMjournal">Surgery</span>
2024 Dec;176(6):1745-1753.
Epub 2024 Sep 10
doi: 10.1016/j.surg.2024.08.007.
<span class="bold">PMID: </span><a href="/pubmed/39261238" target="_blank">39261238</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37952021">Neoadjuvant Therapy for Duodenal and Ampullary Adenocarcinoma: A Systematic Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang C,
Lizalek JM,
Dougherty C,
Westmark DM,
Klute KA,
Reames BN</span><br />
<span class="medgenPMjournal">Ann Surg Oncol</span>
2024 Feb;31(2):792-803.
Epub 2023 Nov 11
doi: 10.1245/s10434-023-14531-y.
<span class="bold">PMID: </span><a href="/pubmed/37952021" target="_blank">37952021</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34012147">Surgical treatment of duodenal adenocarcinoma: ampullary vs. non-ampullary, short- and long-term outcomes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tesarikova J,
Skalicky P,
Kurfurstova D,
Svebisova H,
Urban O,
Falt P,
Zapletalova J,
Klos D,
Lovecek M</span><br />
<span class="medgenPMjournal">Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub</span>
2022 Sep;166(3):290-296.
Epub 2021 May 11
doi: 10.5507/bp.2021.028.
<span class="bold">PMID: </span><a href="/pubmed/34012147" target="_blank">34012147</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29946997">Outcomes and Treatment Options for Duodenal Adenocarcinoma: A Systematic Review and Meta-Analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Meijer LL,
Alberga AJ,
de Bakker JK,
van der Vliet HJ,
Le Large TYS,
van Grieken NCT,
de Vries R,
Daams F,
Zonderhuis BM,
Kazemier G</span><br />
<span class="medgenPMjournal">Ann Surg Oncol</span>
2018 Sep;25(9):2681-2692.
Epub 2018 Jun 26
doi: 10.1245/s10434-018-6567-6.
<span class="bold">PMID: </span><a href="/pubmed/29946997" target="_blank">29946997</a><a href="/pmc/articles/PMC6097725" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25264638">Duodenal adenocarcinoma: why the extreme rarity of duodenal bulb primary tumors?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Goldner B,
Stabile BE</span><br />
<span class="medgenPMjournal">Am Surg</span>
2014 Oct;80(10):956-9.
<span class="bold">PMID: </span><a href="/pubmed/25264638" target="_blank">25264638</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Duodenal%20adenocarcinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (97)</a></div></div>
</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="nl"><a target="_blank" href="/pubmed/37952021">Neoadjuvant Therapy for Duodenal and Ampullary Adenocarcinoma: A Systematic Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang C,
Lizalek JM,
Dougherty C,
Westmark DM,
Klute KA,
Reames BN</span><br />
<span class="medgenPMjournal">Ann Surg Oncol</span>
2024 Feb;31(2):792-803.
Epub 2023 Nov 11
doi: 10.1245/s10434-023-14531-y.
<span class="bold">PMID: </span><a href="/pubmed/37952021" target="_blank">37952021</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37500390">Radiotherapy in the management of rare gastrointestinal cancers: A systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bellefkih FZ,
Benchakroun N,
Lalya I,
Amaoui B,
El Kacemi H,
Acharki A,
El Hfid M,
El Mazghi A,
Chekrine T,
Bouchbika Z,
Jouhadi H,
Sahraoui S,
Tawfiq N,
Michalet M</span><br />
<span class="medgenPMjournal">Cancer Radiother</span>
2023 Sep;27(6-7):622-637.
Epub 2023 Jul 25
doi: 10.1016/j.canrad.2023.06.010.
<span class="bold">PMID: </span><a href="/pubmed/37500390" target="_blank">37500390</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34000722">Risk Factors for Non-Ampullary Duodenal Adenocarcinoma: A Systematic Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yabuuchi Y,
Yoshida M,
Kakushima N,
Kato M,
Iguchi M,
Yamamoto Y,
Kanetaka K,
Uraoka T,
Fujishiro M,
Sho M;
Japan Duodenal Cancer Committee</span><br />
<span class="medgenPMjournal">Dig Dis</span>
2022;40(2):147-155.
Epub 2021 Apr 22
doi: 10.1159/000516561.
<span class="bold">PMID: </span><a href="/pubmed/34000722" target="_blank">34000722</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33386555">Limited resection vs. pancreaticoduodenectomy for primary duodenal adenocarcinoma: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Burasakarn P,
Higuchi R,
Nunobe S,
Kanaji S,
Eguchi H,
Okada KI,
Fujii T,
Nagakawa Y,
Kanetaka K,
Yamashita H,
Yamada S,
Kuroda S,
Aoyama T,
Akahori T,
Nakagawa K,
Yamamoto M,
Yamaue H,
Sho M,
Kodera Y;
Japan Duodenal Cancer Guideline Committee</span><br />
<span class="medgenPMjournal">Int J Clin Oncol</span>
2021 Mar;26(3):450-460.
Epub 2021 Jan 1
doi: 10.1007/s10147-020-01840-5.
<span class="bold">PMID: </span><a href="/pubmed/33386555" target="_blank">33386555</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29946997">Outcomes and Treatment Options for Duodenal Adenocarcinoma: A Systematic Review and Meta-Analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Meijer LL,
Alberga AJ,
de Bakker JK,
van der Vliet HJ,
Le Large TYS,
van Grieken NCT,
de Vries R,
Daams F,
Zonderhuis BM,
Kazemier G</span><br />
<span class="medgenPMjournal">Ann Surg Oncol</span>
2018 Sep;25(9):2681-2692.
Epub 2018 Jun 26
doi: 10.1245/s10434-018-6567-6.
<span class="bold">PMID: </span><a href="/pubmed/29946997" target="_blank">29946997</a><a href="/pmc/articles/PMC6097725" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Duodenal%20adenocarcinoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (10)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Duodenal%20adenocarcinoma" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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