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<meta name="keywords" content="C0268743, ddd mpgnii, ddd mpgniis, dense deposit disease, dense deposit disease / membranoproliferative glomerulonephritis type ii, dgke, disease or syndrome, glomerulonephritis membranoproliferative type 2, mcgn (mesangiocapillary glomerulonephritis) type ii, membranoproliferative glomerulonephritis type 2, membranoproliferative glomerulonephritis type ii, membranoproliferative glomerulonephritis, type ii, mesangiocapillary glomerulonephritis type 2, mesangiocapillary glomerulonephritis, type ii, mpgn 2, mpgn, type ii, mpgnii, mpgnii - membranoproliferative glomerulonephritis type ii, mpgnii, ddd, mpgniis, type ii mpgn, type ii mpgns, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="C3 glomerulopathy (C3G) is a complex ultra-rare complement-mediated renal disease caused by uncontrolled activation of the complement alternative pathway (AP) in the fluid phase (as opposed to cell surface) that is rarely inherited in a simple mendelian fashion. C3G affects individuals of all ages, with a median age at diagnosis of 23 years. Individuals with C3G typically present with hematuria, proteinuria, hematuria and proteinuria, acute nephritic syndrome or nephrotic syndrome, and low levels of the complement component C3. Spontaneous remission of C3G is uncommon, and about half of affected individuals develop end-stage renal disease (ESRD) within ten years of diagnosis, occasionally developing the late comorbidity of impaired visual acuity." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=124345
|
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ConceptID=C0268743
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-->
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<!--imgCountBooks = 6--><div class="ncbi_carousel" data-ncbicarousel-config="imageWidth:'100px',numItemsVisible:2,toggler:false"><div class="nc_header"><span class="img_strip_title">Images (6)</span></div><div class="nc_content"><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1425/bin/mpgn-Image003.gif" src-large="/books/NBK1425/bin/mpgn-Image003.jpg" /></a><br /><a href="/books/NBK1425/figure/mpgn.F3/" title="GeneReviews" target="_blank">details</a></div><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1425/bin/mpgn-Image005.gif" src-large="/books/NBK1425/bin/mpgn-Image005.jpg" /></a><br /><a href="/books/NBK1425/figure/mpgn.F5/" title="GeneReviews" target="_blank">details</a></div><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1425/bin/mpgn-Image002.gif" src-large="/books/NBK1425/bin/mpgn-Image002.jpg" /></a><br /><a href="/books/NBK1425/figure/mpgn.F2/" title="GeneReviews" target="_blank">details</a></div><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1425/bin/mpgn-Image006.gif" src-large="/books/NBK1425/bin/mpgn-Image006.jpg" /></a><br /><a href="/books/NBK1425/figure/mpgn.F6/" title="GeneReviews" target="_blank">details</a></div><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1425/bin/mpgn-Image001.gif" src-large="/books/NBK1425/bin/mpgn-Image001.jpg" /></a><br /><a href="/books/NBK1425/figure/mpgn.F1/" title="GeneReviews" target="_blank">details</a></div><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1425/bin/mpgn-Image004.gif" src-large="/books/NBK1425/bin/mpgn-Image004.jpg" /></a><br /><a href="/books/NBK1425/figure/mpgn.F4/" title="GeneReviews" target="_blank">details</a></div></div></div><h1 class="medgenTitle"><div class="MedGenTitleText">Mesangiocapillary glomerulonephritis, type II</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>124345</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0268743</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Dense deposit disease; Dense Deposit Disease / Membranoproliferative Glomerulonephritis Type II; Membranoproliferative glomerulonephritis type 2; Mesangiocapillary glomerulonephritis type 2; MPGN 2</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Dense deposit disease (722760002); Mesangiocapillary glomerulonephritis type 2 (722760002); Membranoproliferative glomerulonephritis type 2 (722760002); MPGNII - membranoproliferative glomerulonephritis type II (722760002); MCGN (mesangiocapillary glomerulonephritis) type II (722760002)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_141025"><div><strong>Autosomal recessive inheritance</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>141025</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0441748</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Intellectual Product</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygotes (two copies of the same mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).</div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_141025" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal recessive inheritance</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="DGKE - ID: 8526 - NCBI Gene" href="/gene/8526" class="medgenPMinfo">DGKE</a> (17q22)</td></tr>
|
||
<tr><td><a class="help" data-jig="ncbipopper" href="#target-gene-related">Related gene:<img src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div id="target-gene-related" class="display-none">
|
||
Gene(s) associated with related conditions. For conditions<br />
|
||
in a hierarchy, the parent condition will list the genes<br />
|
||
associated with the children conditions.</div></td>
|
||
<td><a target="_blank" href="/gene/81494">CFHR5</a></td></tr><tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0019736" target="_blank">MONDO:0019736</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=93571">ORPHA93571</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_101">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Disease_characteristics">Disease characteristics</h1><a sid="101" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="excerpt">Excerpted from the <i>GeneReview: </i><a href="/books/NBK1425" target="_blank">C3 Glomerulopathy</a></div><div>C3 glomerulopathy (C3G) is a complex ultra-rare complement-mediated renal disease caused by uncontrolled activation of the complement alternative pathway (AP) in the fluid phase (as opposed to cell surface) that is rarely inherited in a simple mendelian fashion. C3G affects individuals of all ages, with a median age at diagnosis of 23 years. Individuals with C3G typically present with hematuria, proteinuria, hematuria and proteinuria, acute nephritic syndrome or nephrotic syndrome, and low levels of the complement component C3. Spontaneous remission of C3G is uncommon, and about half of affected individuals develop end-stage renal disease (ESRD) within ten years of diagnosis, occasionally developing the late comorbidity of impaired visual acuity. [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div><div class="spaceAbove"><strong>Full text of <i>GeneReview</i> (by section):</strong><br /><a class="medgenPMinfo" href="/books/NBK1425#mpgn.Summary" target="NBK1425">Summary</a> | <a class="medgenPMinfo" href="/books/NBK1425#mpgn.Diagnosis" target="NBK1425">Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1425#mpgn.Clinical_Characteristics" target="NBK1425">Clinical Characteristics</a> | <a class="medgenPMinfo" href="/books/NBK1425#mpgn.Genetically_Related_Allelic_Disorde" target="NBK1425">Genetically Related (Allelic) Disorders</a> | <a class="medgenPMinfo" href="/books/NBK1425#mpgn.Differential_Diagnosis" target="NBK1425">Differential Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1425#mpgn.Management" target="NBK1425">Management</a> | <a class="medgenPMinfo" href="/books/NBK1425#mpgn.Genetic_Counseling" target="NBK1425">Genetic Counseling</a> | <a class="medgenPMinfo" href="/books/NBK1425#mpgn.Resources" target="NBK1425">Resources</a> | <a class="medgenPMinfo" href="/books/NBK1425#mpgn.Molecular_Genetics" target="NBK1425">Molecular Genetics</a> | <a class="medgenPMinfo" href="/books/NBK1425#mpgn.References" target="NBK1425">References</a> | <a class="medgenPMinfo" href="/books/NBK1425#mpgn.Chapter_Notes" target="NBK1425">Chapter Notes</a></div><div class="spaceAbove"><strong>Authors:</strong><br />
|
||
Bertha Martín | Richard JH Smith <a href="/books/NBK1425" target="NBK1425" title="NCBI Bookshelf: C3 Glomerulopathy">view full author information</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_117">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_description">Additional description</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From MedlinePlus Genetics</strong><br />C3 glomerulopathy is a group of related conditions that cause the kidneys to malfunction. The major features of C3 glomerulopathy include high levels of protein in the urine (proteinuria), blood in the urine (hematuria), reduced amounts of urine, low levels of protein in the blood, and swelling in many areas of the body. Affected individuals may have particularly low levels of a protein called complement component 3 (or C3) in the blood.<br /><br />One of the two forms of C3 glomerulopathy, dense deposit disease, can also be associated with other conditions unrelated to kidney function. For example, people with dense deposit disease may have acquired partial lipodystrophy, a condition characterized by a lack of fatty (adipose) tissue under the skin in the upper part of the body. Additionally, some people with dense deposit disease develop a buildup of yellowish deposits called drusen in the light-sensitive tissue at the back of the eye (the retina). These deposits usually appear in childhood or adolescence and can cause vision problems later in life.<br /><br />The kidney problems associated with C3 glomerulopathy tend to worsen over time. About half of affected individuals develop end-stage renal disease (ESRD) within 10 years after their diagnosis. ESRD is a life-threatening condition that prevents the kidneys from filtering fluids and waste products from the body effectively.<br /><br />Researchers have identified two major forms of C3 glomerulopathy: dense deposit disease and C3 glomerulonephritis. Although the two disorders cause similar kidney problems, the features of dense deposit disease tend to appear earlier than those of C3 glomerulonephritis, usually in adolescence. However, the signs and symptoms of either disease may not begin until adulthood. <a target="_blank" href="https://medlineplus.gov/genetics/condition/c3-glomerulopathy">https://medlineplus.gov/genetics/condition/c3-glomerulopathy</a></div></div>
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0268743[DISCUI]&test_type=Clinical" ref="ncbi_uid=124345">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1425/" ref="ncbi_uid=124345">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=124345" ref="ncbi_uid=124345">V</a></span></span><span class="TLline">Mesangiocapillary glomerulonephritis, type II</span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=CN071292[DISCUI]&test_type=Clinical" ref="ncbi_uid=434347">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=434347" ref="ncbi_uid=434347">V</a></span></span><span class="TLline"><a href="/medgen/434347" ref="tree=GTR&ncbi_uid=434347&link_uid=434347" title="View MedGen record for 'CFH-Related Dense Deposit Disease / Membranoproliferative Glomerulonephritis Type II'">CFH-Related Dense Deposit Disease / Membranoproliferative Glomerulonephritis Type II</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=CN120381[DISCUI]&test_type=Clinical" ref="ncbi_uid=468546">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1425/" ref="ncbi_uid=468546">G</a></span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/468546" ref="tree=GTR&ncbi_uid=468546&link_uid=468546" title="View MedGen record for 'CFHR5-Related Dense Deposit Disease / Membranoproliferative Glomerulonephritis Type II'">CFHR5-Related Dense Deposit Disease / Membranoproliferative Glomerulonephritis Type II</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/869194" ref="tree=MeSH" title="MedGen record for Abnormality of immune system physiology">Abnormality of immune system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/868411" ref="tree=MeSH" title="MedGen record for Abnormal inflammatory response">Abnormal inflammatory response</a></span><ul><li><span class="TLline"><a href="/medgen/868409" ref="tree=MeSH" title="MedGen record for Increased inflammatory response">Increased inflammatory response</a></span><ul><li><span class="TLline"><a href="/medgen/14328" ref="tree=MeSH" title="MedGen record for Nephritis">Nephritis</a></span><ul><li><span class="TLline"><a href="/medgen/6616" ref="tree=MeSH" title="MedGen record for Glomerulonephritis">Glomerulonephritis</a></span><ul><li><span class="TLline"><a href="/medgen/9033" ref="tree=MeSH" title="MedGen record for Mesangiocapillary glomerulonephritis">Mesangiocapillary glomerulonephritis</a></span><ul><li><span class="matched_ds">Mesangiocapillary glomerulonephritis, type II</span><ul><li><span class="TLline"><a href="/medgen/434347" ref="tree=MeSH" title="MedGen record for CFH-Related Dense Deposit Disease / Membranoproliferative Glomerulonephritis Type II">CFH-Related Dense Deposit Disease / Membranoproliferative Glomerulonephritis Type II</a></span></li><li><span class="TLline"><a href="/medgen/468546" ref="tree=MeSH" title="MedGen record for CFHR5-Related Dense Deposit Disease / Membranoproliferative Glomerulonephritis Type II">CFHR5-Related Dense Deposit Disease / Membranoproliferative Glomerulonephritis Type II</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&data_id=156&PatId=12413&search=Disease_Classif_Simple&new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Mesangiocapillary glomerulonephritis, type II</span> in Orphanet.</div></div></div>
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<div class="portlet mgSection" id="ID_105">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
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||
<div class="nl"><a target="_blank" href="/pubmed/37604793">C3G and Ig-MPGN-treatment standard.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Noris M,
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||
Remuzzi G</span><br />
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||
<span class="medgenPMjournal">Nephrol Dial Transplant</span>
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||
2024 Jan 31;39(2):202-214.
|
||
doi: 10.1093/ndt/gfad182.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37604793" target="_blank">37604793</a><a href="/pmc/articles/PMC10828209" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34596686">Membranoproliferative glomerulonephritis: no longer the same disease and may need very different treatment.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Noris M,
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||
Daina E,
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||
Remuzzi G</span><br />
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<span class="medgenPMjournal">Nephrol Dial Transplant</span>
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||
2023 Feb 13;38(2):283-290.
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||
doi: 10.1093/ndt/gfab281.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34596686" target="_blank">34596686</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32553242">C3 Glomerulopathy: Pathogenesis and Treatment.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Ahmad SB,
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||
Bomback AS</span><br />
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||
<span class="medgenPMjournal">Adv Chronic Kidney Dis</span>
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||
2020 Mar;27(2):104-110.
|
||
doi: 10.1053/j.ackd.2019.12.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32553242" target="_blank">32553242</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(mesangiocapillary%20glomerulonephritis%2C%20type%20ii)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (105)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/17846903">Glycoproteins of drusen and drusen-like lesions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">D'souza Y,
|
||
Jones CJ,
|
||
Bonshek R</span><br />
|
||
<span class="medgenPMjournal">J Mol Histol</span>
|
||
2008 Feb;39(1):77-86.
|
||
Epub 2007 Sep 11
|
||
doi: 10.1007/s10735-007-9130-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17846903" target="_blank">17846903</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2658560">Mesangiocapillary glomerulonephritis type II (dense-deposit disease): clinical features of progressive disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bennett WM,
|
||
Fassett RG,
|
||
Walker RG,
|
||
Fairley KF,
|
||
d'Apice AJ,
|
||
Kincaid-Smith P</span><br />
|
||
<span class="medgenPMjournal">Am J Kidney Dis</span>
|
||
1989 Jun;13(6):469-76.
|
||
doi: 10.1016/s0272-6386(89)80004-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2658560" target="_blank">2658560</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2605145">Fundus changes in mesangiocapillary glomerulonephritis type II: vitreous fluorophotometry.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Raines MF,
|
||
Duvall-Young J,
|
||
Short CD</span><br />
|
||
<span class="medgenPMjournal">Br J Ophthalmol</span>
|
||
1989 Nov;73(11):907-10.
|
||
doi: 10.1136/bjo.73.11.907.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2605145" target="_blank">2605145</a><a href="/pmc/articles/PMC1041924" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2605144">Fundus changes in mesangiocapillary glomerulonephritis type II: clinical and fluorescein angiographic findings.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Duvall-Young J,
|
||
Short CD,
|
||
Raines MF,
|
||
Gokal R,
|
||
Lawler W</span><br />
|
||
<span class="medgenPMjournal">Br J Ophthalmol</span>
|
||
1989 Nov;73(11):900-6.
|
||
doi: 10.1136/bjo.73.11.900.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2605144" target="_blank">2605144</a><a href="/pmc/articles/PMC1041923" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mesangiocapillary%20glomerulonephritis%2C%20type%20II%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/17846903">Glycoproteins of drusen and drusen-like lesions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">D'souza Y,
|
||
Jones CJ,
|
||
Bonshek R</span><br />
|
||
<span class="medgenPMjournal">J Mol Histol</span>
|
||
2008 Feb;39(1):77-86.
|
||
Epub 2007 Sep 11
|
||
doi: 10.1007/s10735-007-9130-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17846903" target="_blank">17846903</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mesangiocapillary%20glomerulonephritis%2C%20type%20II%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/2303589">Systemic lupus erythematosus in a patient with partial lipodystrophy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Font J,
|
||
Herrero C,
|
||
Bosch X,
|
||
Cervera R,
|
||
Ingelmo M,
|
||
Mascaró JM</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Dermatol</span>
|
||
1990 Feb;22(2 Pt 2):337-40.
|
||
doi: 10.1016/0190-9622(90)70042-g.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2303589" target="_blank">2303589</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mesangiocapillary%20glomerulonephritis%2C%20type%20II%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/2658560">Mesangiocapillary glomerulonephritis type II (dense-deposit disease): clinical features of progressive disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bennett WM,
|
||
Fassett RG,
|
||
Walker RG,
|
||
Fairley KF,
|
||
d'Apice AJ,
|
||
Kincaid-Smith P</span><br />
|
||
<span class="medgenPMjournal">Am J Kidney Dis</span>
|
||
1989 Jun;13(6):469-76.
|
||
doi: 10.1016/s0272-6386(89)80004-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2658560" target="_blank">2658560</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mesangiocapillary%20glomerulonephritis%2C%20type%20II%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
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</div>
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<div class="supplemental col three_col last">
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||
<h2 class="offscreen_noflow">Supplemental Content</h2>
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||
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||
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|
||
|
||
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||
<div class="rightCol mgCol">
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0268743%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (2)</a></li>
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||
<li><a href="/gtr/tests?term=C0268743%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (3)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0268743%5bDISCUI%5d" target="_blank">See all (3)</a></total></li>
|
||
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|
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|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=93571" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Mesangiocapillary%20glomerulonephritis,%20type%20II" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(mesangiocapillary%20glomerulonephritis%2C%20type%20ii)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Mesangiocapillary%20glomerulonephritis%2C%20type%20II%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67cb57f9b15b832ebc239c0d">Mesangiocapillary glomerulonephritis, type II</a>
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