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<meta name="keywords" content="C0220633, choroidal melanoma, intraocular melanoma, iris melanoma, melanoma (disease) of uvea, melanoma of the uvea, melanoma of uvea, melanoma, intraocular, melanoma, ocular, melanoma, uveal, melanoma, uveal, malignant, neoplastic process, ocular melanoma, uvea melanoma, uvea melanoma (disease), uveal melanoma, uveal tract melanoma, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Uveal melanoma is a highly malignant tumor that arises from the choroid or the ciliary body of the eye. It is the most common primary ocular malignancy in adults, although it has a low incidence (6 cases per 1,000,000 per year). A tendency for hematogenic spread to the liver accounts for up to 50% of patient deaths (summary by Lopez et al., 2007)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
|
||
UID=65077
|
||
ConceptID=C0220633
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Uveal melanoma</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>65077</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0220633</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Intraocular melanoma; Melanoma of the Uvea</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information.">CN307044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0007716">HP:0007716</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0006486" target="_blank">MONDO:0006486</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/155720" target="_blank">155720</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=39044">ORPHA39044</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_100">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Uveal melanoma is a highly malignant tumor that arises from the choroid or the ciliary body of the eye. It is the most common primary ocular malignancy in adults, although it has a low incidence (6 cases per 1,000,000 per year). A tendency for hematogenic spread to the liver accounts for up to 50% of patient deaths (summary by Lopez et al., 2007). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_65077"><div><strong>Uveal melanoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>65077</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0220633</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Uveal melanoma is a highly malignant tumor that arises from the choroid or the ciliary body of the eye. It is the most common primary ocular malignancy in adults, although it has a low incidence (6 cases per 1,000,000 per year). A tendency for hematogenic spread to the liver accounts for up to 50% of patient deaths (summary by Lopez et al., 2007).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/65077">Feature record</a> | <a href="/medgen?term=%22Uveal%20melanoma%22%5BClinical%20Features%5D%20OR%2065077%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Abnormality of the eye</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_65077" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Uveal melanoma</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0220633[DISCUI]&test_type=Clinical" ref="ncbi_uid=65077">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=65077" target="_blank" href="/omim/155720">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=65077" ref="ncbi_uid=65077">V</a></span></span><span class="TLline">Uveal melanoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="matched_ds">Uveal melanoma</span><ul><li><span class="TLline"><a href="/medgen/1643389" ref="tree=MeSH" title="MedGen record for Choroidal and Ciliary Body Melanoma by AJCC v8 Stage">Choroidal and Ciliary Body Melanoma by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1638201" ref="tree=MeSH" title="MedGen record for Stage I Choroidal and Ciliary Body Melanoma AJCC v8">Stage I Choroidal and Ciliary Body Melanoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1634465" ref="tree=MeSH" title="MedGen record for Stage II Choroidal and Ciliary Body Melanoma AJCC v8">Stage II Choroidal and Ciliary Body Melanoma AJCC v8</a></span><ul><li><span class="TLline"><a href="/medgen/1641705" ref="tree=MeSH" title="MedGen record for Stage IIA Choroidal and Ciliary Body Melanoma AJCC v8">Stage IIA Choroidal and Ciliary Body Melanoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1646446" ref="tree=MeSH" title="MedGen record for Stage IIB Choroidal and Ciliary Body Melanoma AJCC v8">Stage IIB Choroidal and Ciliary Body Melanoma AJCC v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1637939" ref="tree=MeSH" title="MedGen record for Stage III Choroidal and Ciliary Body Melanoma AJCC v8">Stage III Choroidal and Ciliary Body Melanoma AJCC v8</a></span><ul><li><span class="TLline"><a href="/medgen/1645919" ref="tree=MeSH" title="MedGen record for Stage IIIA Choroidal and Ciliary Body Melanoma AJCC v8">Stage IIIA Choroidal and Ciliary Body Melanoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1641380" ref="tree=MeSH" title="MedGen record for Stage IIIB Choroidal and Ciliary Body Melanoma AJCC v8">Stage IIIB Choroidal and Ciliary Body Melanoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1635196" ref="tree=MeSH" title="MedGen record for Stage IIIC Choroidal and Ciliary Body Melanoma AJCC v8">Stage IIIC Choroidal and Ciliary Body Melanoma AJCC v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1644774" ref="tree=MeSH" title="MedGen record for Stage IV Choroidal and Ciliary Body Melanoma AJCC v8">Stage IV Choroidal and Ciliary Body Melanoma AJCC v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/138064" ref="tree=MeSH" title="MedGen record for Choroidal melanoma">Choroidal melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/232360" ref="tree=MeSH" title="MedGen record for Choroid epithelioid cell melanoma">Choroid epithelioid cell melanoma</a></span></li><li><span class="TLline"><a href="/medgen/232361" ref="tree=MeSH" title="MedGen record for Choroid mixed cell melanoma">Choroid mixed cell melanoma</a></span></li><li><span class="TLline"><a href="/medgen/232362" ref="tree=MeSH" title="MedGen record for Choroid necrotic melanoma">Choroid necrotic melanoma</a></span></li><li><span class="TLline"><a href="/medgen/272477" ref="tree=MeSH" title="MedGen record for Choroid spindle cell melanoma">Choroid spindle cell melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/234142" ref="tree=MeSH" title="MedGen record for Choroid Spindle Cell Type A Melanoma">Choroid Spindle Cell Type A Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/272478" ref="tree=MeSH" title="MedGen record for Choroid Spindle Cell Type B Melanoma">Choroid Spindle Cell Type B Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/272760" ref="tree=MeSH" title="MedGen record for Intermediate cell type choroid melanoma">Intermediate cell type choroid melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1712820" ref="tree=MeSH" title="MedGen record for Metastatic Choroid Melanoma">Metastatic Choroid Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/138062" ref="tree=MeSH" title="MedGen record for Ciliary body melanoma">Ciliary body melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/272484" ref="tree=MeSH" title="MedGen record for Ciliary body epithelioid cell melanoma">Ciliary body epithelioid cell melanoma</a></span></li><li><span class="TLline"><a href="/medgen/234150" ref="tree=MeSH" title="MedGen record for Ciliary body mixed cell melanoma">Ciliary body mixed cell melanoma</a></span></li><li><span class="TLline"><a href="/medgen/232367" ref="tree=MeSH" title="MedGen record for Ciliary body spindle cell melanoma">Ciliary body spindle cell melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/232368" ref="tree=MeSH" title="MedGen record for Ciliary Body Spindle Cell Type A Melanoma">Ciliary Body Spindle Cell Type A Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/232078" ref="tree=MeSH" title="MedGen record for Ciliary Body Spindle Cell Type B Melanoma">Ciliary Body Spindle Cell Type B Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/233563" ref="tree=MeSH" title="MedGen record for Intermediate cell type ciliary body melanoma">Intermediate cell type ciliary body melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/234223" ref="tree=MeSH" title="MedGen record for Epithelioid cell uveal melanoma">Epithelioid cell uveal melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/1758581" ref="tree=MeSH" title="MedGen record for Iris Epithelioid Cell Melanoma">Iris Epithelioid Cell Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/76016" ref="tree=MeSH" title="MedGen record for Intermediate cell type uveal melanoma">Intermediate cell type uveal melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/233564" ref="tree=MeSH" title="MedGen record for Intermediate cell type iris melanoma">Intermediate cell type iris melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/87559" ref="tree=MeSH" title="MedGen record for Iris melanoma">Iris melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/1756478" ref="tree=MeSH" title="MedGen record for Iris Mixed Cell Melanoma">Iris Mixed Cell Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/232672" ref="tree=MeSH" title="MedGen record for Iris spindle cell melanoma">Iris spindle cell melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/124525" ref="tree=MeSH" title="MedGen record for Medium/large size posterior uveal melanoma">Medium/large size posterior uveal melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1649122" ref="tree=MeSH" title="MedGen record for Metastatic Uveal Melanoma">Metastatic Uveal Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/1663216" ref="tree=MeSH" title="MedGen record for Advanced Uveal Melanoma">Advanced Uveal Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/1660346" ref="tree=MeSH" title="MedGen record for Uveal Melanoma Metastatic in the Liver">Uveal Melanoma Metastatic in the Liver</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/235330" ref="tree=MeSH" title="MedGen record for Mixed cell uveal melanoma">Mixed cell uveal melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1669717" ref="tree=MeSH" title="MedGen record for Necrotic uveal melanoma">Necrotic uveal melanoma</a></span></li><li><span class="TLline"><a href="/medgen/75885" ref="tree=MeSH" title="MedGen record for Recurrent Uveal Melanoma">Recurrent Uveal Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1771214" ref="tree=MeSH" title="MedGen record for Refractory Uveal Melanoma">Refractory Uveal Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/75883" ref="tree=MeSH" title="MedGen record for Small size posterior uveal melanoma">Small size posterior uveal melanoma</a></span></li><li><span class="TLline"><a href="/medgen/76015" ref="tree=MeSH" title="MedGen record for Spindle cell intraocular melanoma">Spindle cell intraocular melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/234808" ref="tree=MeSH" title="MedGen record for Uveal Spindle Cell Type A Melanoma">Uveal Spindle Cell Type A Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/236839" ref="tree=MeSH" title="MedGen record for Uveal Spindle Cell Type B Melanoma">Uveal Spindle Cell Type B Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1726417" ref="tree=MeSH" title="MedGen record for Unresectable Uveal Melanoma">Unresectable Uveal Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1631926" ref="tree=MeSH" title="MedGen record for Uveal Melanoma by AJCC v7 Stage">Uveal Melanoma by AJCC v7 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/234362" ref="tree=MeSH" title="MedGen record for Stage I Uveal Melanoma AJCC v7">Stage I Uveal Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/236913" ref="tree=MeSH" title="MedGen record for Stage II Uveal Melanoma AJCC v7">Stage II Uveal Melanoma AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/453933" ref="tree=MeSH" title="MedGen record for Stage IIA Uveal Melanoma AJCC v7">Stage IIA Uveal Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/453934" ref="tree=MeSH" title="MedGen record for Stage IIB Uveal Melanoma AJCC v7">Stage IIB Uveal Melanoma AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/236901" ref="tree=MeSH" title="MedGen record for Stage III Uveal Melanoma AJCC v7">Stage III Uveal Melanoma AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/453935" ref="tree=MeSH" title="MedGen record for Stage IIIA Uveal Melanoma AJCC v7">Stage IIIA Uveal Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/453936" ref="tree=MeSH" title="MedGen record for Stage IIIB Uveal Melanoma AJCC v7">Stage IIIB Uveal Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/453937" ref="tree=MeSH" title="MedGen record for Stage IIIC Uveal Melanoma AJCC v7">Stage IIIC Uveal Melanoma AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/236945" ref="tree=MeSH" title="MedGen record for Stage IV Uveal Melanoma AJCC v7">Stage IV Uveal Melanoma AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/819941" ref="tree=MeSH" title="MedGen record for Uveal Melanoma by Gene Expression Profile">Uveal Melanoma by Gene Expression Profile</a></span><ul><li><span class="TLline"><a href="/medgen/823836" ref="tree=MeSH" title="MedGen record for Uveal Class 1 Melanoma">Uveal Class 1 Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/823838" ref="tree=MeSH" title="MedGen record for Uveal Class 1a Melanoma">Uveal Class 1a Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/823837" ref="tree=MeSH" title="MedGen record for Uveal Class 1b Melanoma">Uveal Class 1b Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/823835" ref="tree=MeSH" title="MedGen record for Uveal Class 2 Melanoma">Uveal Class 2 Melanoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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<div class="divPopper rprt" id="rdis_65077"><div><strong>Uveal melanoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>65077</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0220633</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">Uveal melanoma is a highly malignant tumor that arises from the choroid or the ciliary body of the eye. It is the most common primary ocular malignancy in adults, although it has a low incidence (6 cases per 1,000,000 per year). A tendency for hematogenic spread to the liver accounts for up to 50% of patient deaths (summary by Lopez et al., 2007).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/65077">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_322559"><div><strong>Melanoma, malignant familial intraocular</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>322559</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1835043</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/322559">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_320506"><div><strong>Melanoma, cutaneous malignant, susceptibility to, 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>320506</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1835047</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Malignant melanoma is a neoplasm of pigment-producing cells called melanocytes that occurs most often in the skin, but may also occur in the eyes, ears, gastrointestinal tract, leptomeninges, and oral and genital mucous membranes (summary by Habif, 2010). Genetic Heterogeneity of Susceptibility to Cutaneous Malignant Melanoma The locus for susceptibility to familial cutaneous malignant melanoma-1 (CMM1) has been mapped to chromosome 1p36. Other CMM susceptibility loci include CMM2 (155601), caused by variation in the CDKN2A gene (600160) on chromosome 9p21; CMM3 (609048), caused by variation in the CDK4 gene (123829) on chromosome 12q14; CMM4 (608035), mapped to chromosome 1p22; CMM5 (613099), caused by variation in the MC1R gene (155555) on chromosome 16q24; CMM6 (613972), caused by variation in the XRCC3 gene (600675) on chromosome 14q32; CMM7 (612263), mapped to chromosome 20q11; CMM8 (614456), caused by variation in the MITF gene (156845) on chromosome 3p13; CMM9 (615134), caused by variation in the TERT gene (187270) on chromosome 5p15; and CMM10 (615848), caused by mutation in the POT1 gene (606478) on chromosome 7q31. Somatic mutations causing malignant melanoma have also been identified in several genes, including BRAF (164757), STK11 (602216), PTEN (601728), TRRAP (603015), DCC (120470), GRIN2A (138253), ZNF831, BAP1 (603089), and RASA2 (601589). A large percentage of melanomas (40-60%) carry an activating somatic mutation in the BRAF gene, most often V600E (164757.0001) (Davies et al., 2002; Pollock et al., 2003).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/320506">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_339826"><div><strong>Melanoma, uveal, susceptibility to, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>339826</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1847723</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Uveal melanoma (see 155720) is the most common primary intraocular malignancy. Metastases arise in more than 30% of patients, usually to the liver, with a poor prognosis (median survival of 10 months) (summary by Derrien et al., 2021). Somatic monosomy 3, which is an unusual finding in most tumors, is present in approximately 50% of uveal melanomas and is significantly correlated with metastatic disease (summary by Tschentscher et al., 2001). Mutation in the BAP1 gene is known to confer susceptibility to this specific disease. It has been estimated that about 22% of cases of familial uveal melanoma are due to BAP1 mutations. Conversely, uveal melanoma has been reported in about 31% of BAP1 mutation carriers, making it one of the most common manifestations of TPDS1 (Rai et al., 2016; Rai et al., 2017). For a discussion of genetic heterogeneity of susceptibility to uveal melanoma, see UVM1 (606660), caused by mutation in the MBD4 gene (603574) on chromosome 3q21.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/339826">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_376198"><div><strong>Melanoma, uveal, susceptibility to, 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>376198</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1847724</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Uveal melanoma (see 155720) is the most common primary intraocular malignancy. Metastases arise in more than 30% of patients, usually to the liver, with a poor prognosis (median survival of 10 months). Somatic monosomy 3, which is an unusual finding in most tumors, is present in approximately 50% of uveal melanomas and is significantly correlated with metastatic disease (summary by Tschentscher et al., 2001; Derrien et al., 2021). Treatment with programmed cell death protein-1 inhibitors may result in clinical improvement (Rodrigues et al., 2018).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/376198">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_482122"><div><strong>BAP1-related tumor predisposition syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482122</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3280492</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">BAP1 tumor predisposition syndrome (BAP1-TPDS) is associated with an increased risk for a specific skin lesion, BAP1-inactivated melanocytic tumors (BIMT; formerly called atypical Spitz tumors), and the following cancers, in descending order of frequency: uveal (eye) melanoma (UM), malignant mesothelioma (MMe), cutaneous melanoma (CM), renal cell carcinoma (RCC), basal cell carcinoma (BCC), meningioma, and cholangiocarcinoma. Onychopapillomas, hepatocellular carcinoma, and ovarian sex cord-stromal tumors may also be associated with BAP1-TPDS. Affected individuals can have more than one type of primary cancer. In general, the median age of onset of these tumors is younger than in the general population. UM tends to be a more aggressive class 2 tumor with higher risk for metastasis and reduced survival compared to UM occurring in the general population. RCC is usually of clear cell morphology, but other pathologies have been reported. MMe, especially pleural, has better survival and responds better to platinum chemotherapy than MMe not associated with a germline BAP1 pathogenic variant. The penetrance, natural history, life-time cancer risk for carriers, and frequencies of BAP1-associated tumors are yet to be fully determined.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/482122">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1823959"><div><strong>Tumor predisposition syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1823959</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5774186</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Tumor predisposition syndrome-2 (TPDS2) is an autosomal recessive cancer predisposition syndrome characterized by the onset of various types of tumors or malignancies in young adulthood. The most common clinical manifestations include acute myeloid leukemia (AML), myelodysplastic syndrome, colorectal adenomatous polyposis and carcinoma, and uveal melanoma, although other tumors and malignancies have been reported (summary by Palles et al., 2022). For a discussion of genetic heterogeneity of TPDS, see TPDS1 (614327).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1823959">Condition Record</a></div></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482122" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">BAP1-related tumor predisposition syndrome</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_320506" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Melanoma, cutaneous malignant, susceptibility to, 1</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_322559" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Melanoma, malignant familial intraocular</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_376198" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Melanoma, uveal, susceptibility to, 1</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_339826" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Melanoma, uveal, susceptibility to, 2</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1823959" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Tumor predisposition syndrome 2</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_65077" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Uveal melanoma</a></div></div>
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<div class="portlet mgSection" id="ID_105">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
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<div class="nl"><a target="_blank" href="/pubmed/37579248">Systemic Therapy for Melanoma: ASCO Guideline Update.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Seth R,
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Agarwala SS,
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Messersmith H,
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Alluri KC,
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Ascierto PA,
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Atkins MB,
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Bollin K,
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Chacon M,
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Davis N,
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Faries MB,
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Funchain P,
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Gold JS,
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Guild S,
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Gyorki DE,
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Kaur V,
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Khushalani NI,
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||
Kirkwood JM,
|
||
McQuade JL,
|
||
Meyers MO,
|
||
Provenzano A,
|
||
Robert C,
|
||
Santinami M,
|
||
Sehdev A,
|
||
Sondak VK,
|
||
Spurrier G,
|
||
Swami U,
|
||
Truong TG,
|
||
Tsai KK,
|
||
van Akkooi A,
|
||
Weber J</span><br />
|
||
<span class="medgenPMjournal">J Clin Oncol</span>
|
||
2023 Oct 20;41(30):4794-4820.
|
||
Epub 2023 Aug 14
|
||
doi: 10.1200/JCO.23.01136.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37579248" target="_blank">37579248</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36600005">Advances in the clinical management of uveal melanoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Carvajal RD,
|
||
Sacco JJ,
|
||
Jager MJ,
|
||
Eschelman DJ,
|
||
Olofsson Bagge R,
|
||
Harbour JW,
|
||
Chieng ND,
|
||
Patel SP,
|
||
Joshua AM,
|
||
Piperno-Neumann S</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Clin Oncol</span>
|
||
2023 Feb;20(2):99-115.
|
||
Epub 2023 Jan 4
|
||
doi: 10.1038/s41571-022-00714-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36600005" target="_blank">36600005</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26991400">Uveal melanoma: From diagnosis to treatment and the science in between.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chattopadhyay C,
|
||
Kim DW,
|
||
Gombos DS,
|
||
Oba J,
|
||
Qin Y,
|
||
Williams MD,
|
||
Esmaeli B,
|
||
Grimm EA,
|
||
Wargo JA,
|
||
Woodman SE,
|
||
Patel SP</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
2016 Aug 1;122(15):2299-312.
|
||
Epub 2016 Mar 15
|
||
doi: 10.1002/cncr.29727.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26991400" target="_blank">26991400</a><a href="/pmc/articles/PMC5567680" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22uveal%20melanoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (284)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/uveal.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Melanoma: Uveal, 2023</a></h3>
|
||
<h3 class="nl vspace"><a href="https://www.nice.org.uk/guidance/ng14" target="_blank">UK NICE Guideline NG14, Melanoma: assessment and management, 2022</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_114">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Suggested_Reading">Suggested Reading</h1><a sid="114" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/21773036">Uveal melanoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Papastefanou VP,
|
||
Cohen VM</span><br />
|
||
<span class="medgenPMjournal">J Skin Cancer</span>
|
||
2011;2011:573974.
|
||
Epub 2011 Jun 30
|
||
doi: 10.1155/2011/573974.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21773036" target="_blank">21773036</a><a href="/pmc/articles/PMC3135138" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=" title="PubMed search"></a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39596556">Genetic Features of Uveal Melanoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sorrentino FS,
|
||
Culiersi C,
|
||
Florido A,
|
||
De Nadai K,
|
||
Adamo GG,
|
||
Nasini F,
|
||
Vivarelli C,
|
||
Mura M,
|
||
Parmeggiani F</span><br />
|
||
<span class="medgenPMjournal">Genes (Basel)</span>
|
||
2024 Oct 22;15(11)
|
||
doi: 10.3390/genes15111356.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39596556" target="_blank">39596556</a><a href="/pmc/articles/PMC11593461" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36600005">Advances in the clinical management of uveal melanoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Carvajal RD,
|
||
Sacco JJ,
|
||
Jager MJ,
|
||
Eschelman DJ,
|
||
Olofsson Bagge R,
|
||
Harbour JW,
|
||
Chieng ND,
|
||
Patel SP,
|
||
Joshua AM,
|
||
Piperno-Neumann S</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Clin Oncol</span>
|
||
2023 Feb;20(2):99-115.
|
||
Epub 2023 Jan 4
|
||
doi: 10.1038/s41571-022-00714-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36600005" target="_blank">36600005</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34999237">Metastatic uveal melanoma: The final frontier.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rantala ES,
|
||
Hernberg MM,
|
||
Piperno-Neumann S,
|
||
Grossniklaus HE,
|
||
Kivelä TT</span><br />
|
||
<span class="medgenPMjournal">Prog Retin Eye Res</span>
|
||
2022 Sep;90:101041.
|
||
Epub 2022 Jan 6
|
||
doi: 10.1016/j.preteyeres.2022.101041.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34999237" target="_blank">34999237</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27911450">Uveal melanoma: relatively rare but deadly cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kaliki S,
|
||
Shields CL</span><br />
|
||
<span class="medgenPMjournal">Eye (Lond)</span>
|
||
2017 Feb;31(2):241-257.
|
||
Epub 2016 Dec 2
|
||
doi: 10.1038/eye.2016.275.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27911450" target="_blank">27911450</a><a href="/pmc/articles/PMC5306463" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26991400">Uveal melanoma: From diagnosis to treatment and the science in between.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chattopadhyay C,
|
||
Kim DW,
|
||
Gombos DS,
|
||
Oba J,
|
||
Qin Y,
|
||
Williams MD,
|
||
Esmaeli B,
|
||
Grimm EA,
|
||
Wargo JA,
|
||
Woodman SE,
|
||
Patel SP</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
2016 Aug 1;122(15):2299-312.
|
||
Epub 2016 Mar 15
|
||
doi: 10.1002/cncr.29727.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26991400" target="_blank">26991400</a><a href="/pmc/articles/PMC5567680" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Uveal%20melanoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1886)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38295889">The treatment of advanced melanoma: Current approaches and new challenges.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Boutros A,
|
||
Croce E,
|
||
Ferrari M,
|
||
Gili R,
|
||
Massaro G,
|
||
Marconcini R,
|
||
Arecco L,
|
||
Tanda ET,
|
||
Spagnolo F</span><br />
|
||
<span class="medgenPMjournal">Crit Rev Oncol Hematol</span>
|
||
2024 Apr;196:104276.
|
||
Epub 2024 Jan 29
|
||
doi: 10.1016/j.critrevonc.2024.104276.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38295889" target="_blank">38295889</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34999237">Metastatic uveal melanoma: The final frontier.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rantala ES,
|
||
Hernberg MM,
|
||
Piperno-Neumann S,
|
||
Grossniklaus HE,
|
||
Kivelä TT</span><br />
|
||
<span class="medgenPMjournal">Prog Retin Eye Res</span>
|
||
2022 Sep;90:101041.
|
||
Epub 2022 Jan 6
|
||
doi: 10.1016/j.preteyeres.2022.101041.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34999237" target="_blank">34999237</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27911450">Uveal melanoma: relatively rare but deadly cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kaliki S,
|
||
Shields CL</span><br />
|
||
<span class="medgenPMjournal">Eye (Lond)</span>
|
||
2017 Feb;31(2):241-257.
|
||
Epub 2016 Dec 2
|
||
doi: 10.1038/eye.2016.275.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27911450" target="_blank">27911450</a><a href="/pmc/articles/PMC5306463" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26991400">Uveal melanoma: From diagnosis to treatment and the science in between.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chattopadhyay C,
|
||
Kim DW,
|
||
Gombos DS,
|
||
Oba J,
|
||
Qin Y,
|
||
Williams MD,
|
||
Esmaeli B,
|
||
Grimm EA,
|
||
Wargo JA,
|
||
Woodman SE,
|
||
Patel SP</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
2016 Aug 1;122(15):2299-312.
|
||
Epub 2016 Mar 15
|
||
doi: 10.1002/cncr.29727.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26991400" target="_blank">26991400</a><a href="/pmc/articles/PMC5567680" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15763199">Metastatic uveal melanoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Singh AD,
|
||
Borden EC</span><br />
|
||
<span class="medgenPMjournal">Ophthalmol Clin North Am</span>
|
||
2005 Mar;18(1):143-50, ix.
|
||
doi: 10.1016/j.ohc.2004.07.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15763199" target="_blank">15763199</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Uveal%20melanoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1530)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37870955">Three-Year Overall Survival with Tebentafusp in Metastatic Uveal Melanoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hassel JC,
|
||
Piperno-Neumann S,
|
||
Rutkowski P,
|
||
Baurain JF,
|
||
Schlaak M,
|
||
Butler MO,
|
||
Sullivan RJ,
|
||
Dummer R,
|
||
Kirkwood JM,
|
||
Orloff M,
|
||
Sacco JJ,
|
||
Ochsenreither S,
|
||
Joshua AM,
|
||
Gastaud L,
|
||
Curti B,
|
||
Piulats JM,
|
||
Salama AKS,
|
||
Shoushtari AN,
|
||
Demidov L,
|
||
Milhem M,
|
||
Chmielowski B,
|
||
Kim KB,
|
||
Carvajal RD,
|
||
Hamid O,
|
||
Collins L,
|
||
Ranade K,
|
||
Holland C,
|
||
Pfeiffer C,
|
||
Nathan P</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2023 Dec 14;389(24):2256-2266.
|
||
Epub 2023 Oct 21
|
||
doi: 10.1056/NEJMoa2304753.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37870955" target="_blank">37870955</a><a href="/pmc/articles/PMC11188986" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34999237">Metastatic uveal melanoma: The final frontier.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rantala ES,
|
||
Hernberg MM,
|
||
Piperno-Neumann S,
|
||
Grossniklaus HE,
|
||
Kivelä TT</span><br />
|
||
<span class="medgenPMjournal">Prog Retin Eye Res</span>
|
||
2022 Sep;90:101041.
|
||
Epub 2022 Jan 6
|
||
doi: 10.1016/j.preteyeres.2022.101041.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34999237" target="_blank">34999237</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34551229">Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nathan P,
|
||
Hassel JC,
|
||
Rutkowski P,
|
||
Baurain JF,
|
||
Butler MO,
|
||
Schlaak M,
|
||
Sullivan RJ,
|
||
Ochsenreither S,
|
||
Dummer R,
|
||
Kirkwood JM,
|
||
Joshua AM,
|
||
Sacco JJ,
|
||
Shoushtari AN,
|
||
Orloff M,
|
||
Piulats JM,
|
||
Milhem M,
|
||
Salama AKS,
|
||
Curti B,
|
||
Demidov L,
|
||
Gastaud L,
|
||
Mauch C,
|
||
Yushak M,
|
||
Carvajal RD,
|
||
Hamid O,
|
||
Abdullah SE,
|
||
Holland C,
|
||
Goodall H,
|
||
Piperno-Neumann S;
|
||
IMCgp100-202 Investigators</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2021 Sep 23;385(13):1196-1206.
|
||
doi: 10.1056/NEJMoa2103485.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34551229" target="_blank">34551229</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27911450">Uveal melanoma: relatively rare but deadly cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kaliki S,
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Shields CL</span><br />
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<span class="medgenPMjournal">Eye (Lond)</span>
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2017 Feb;31(2):241-257.
|
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Epub 2016 Dec 2
|
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doi: 10.1038/eye.2016.275.
|
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<span class="bold">PMID: </span><a href="/pubmed/27911450" target="_blank">27911450</a><a href="/pmc/articles/PMC5306463" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div class="nl"><a target="_blank" href="/pubmed/27898611">Immunotherapy for Uveal Melanoma.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Breazzano MP,
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Milam RW Jr,
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Batson SA,
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Johnson DB,
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<span class="medgenPMjournal">Int Ophthalmol Clin</span>
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2017 Winter;57(1):29-39.
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doi: 10.1097/IIO.0000000000000148.
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<span class="bold">PMID: </span><a href="/pubmed/27898611" target="_blank">27898611</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Uveal%20melanoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1044)</a></div><h3 class="subhead">Prognosis</h3>
|
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<div class="nl"><a target="_blank" href="/pubmed/31067375">Metastatic Uveal Melanoma.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Everett L,
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Copperman T</span><br />
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2019 May 9;380(19):1853.
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<span class="bold">PMID: </span><a href="/pubmed/31067375" target="_blank">31067375</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/27911450">Uveal melanoma: relatively rare but deadly cancer.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Kaliki S,
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Shields CL</span><br />
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<span class="medgenPMjournal">Eye (Lond)</span>
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2017 Feb;31(2):241-257.
|
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Epub 2016 Dec 2
|
||
doi: 10.1038/eye.2016.275.
|
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<span class="bold">PMID: </span><a href="/pubmed/27911450" target="_blank">27911450</a><a href="/pmc/articles/PMC5306463" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/27574175">Metastatic disease from uveal melanoma: treatment options and future prospects.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Carvajal RD,
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Schwartz GK,
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Tezel T,
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Marr B,
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Francis JH,
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Nathan PD</span><br />
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<span class="medgenPMjournal">Br J Ophthalmol</span>
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2017 Jan;101(1):38-44.
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Epub 2016 Aug 29
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doi: 10.1136/bjophthalmol-2016-309034.
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<span class="bold">PMID: </span><a href="/pubmed/27574175" target="_blank">27574175</a><a href="/pmc/articles/PMC5256122" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/16365560">Metastatic uveal melanoma.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Kivelä T,
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Eskelin S,
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Kujala E</span><br />
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<span class="medgenPMjournal">Int Ophthalmol Clin</span>
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2006 Winter;46(1):133-49.
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doi: 10.1097/01.iio.0000195861.71558.13.
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<span class="bold">PMID: </span><a href="/pubmed/16365560" target="_blank">16365560</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/15327097">Uveal melanoma: update and future directions.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Rousseau AP</span><br />
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<span class="medgenPMjournal">Can J Ophthalmol</span>
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2004 Jun;39(4):335-42.
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doi: 10.1016/s0008-4182(04)80003-6.
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<span class="bold">PMID: </span><a href="/pubmed/15327097" target="_blank">15327097</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Uveal%20melanoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1903)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
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<div class="nl"><a target="_blank" href="/pubmed/39596556">Genetic Features of Uveal Melanoma.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Sorrentino FS,
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Culiersi C,
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Florido A,
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De Nadai K,
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Adamo GG,
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Nasini F,
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Vivarelli C,
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Mura M,
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Parmeggiani F</span><br />
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<span class="medgenPMjournal">Genes (Basel)</span>
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2024 Oct 22;15(11)
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doi: 10.3390/genes15111356.
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<span class="bold">PMID: </span><a href="/pubmed/39596556" target="_blank">39596556</a><a href="/pmc/articles/PMC11593461" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36793711">Identification of a novel immune-related gene signature for prognosis and the tumor microenvironment in patients with uveal melanoma combining single-cell and bulk sequencing data.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Wang W,
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Zhao H,
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Wang S</span><br />
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<span class="medgenPMjournal">Front Immunol</span>
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2023;14:1099071.
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Epub 2023 Jan 30
|
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doi: 10.3389/fimmu.2023.1099071.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36793711" target="_blank">36793711</a><a href="/pmc/articles/PMC9922847" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36605187">Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khan M,
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Ai M,
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Du K,
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Song J,
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Wang B,
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Lin J,
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Ren A,
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Chen C,
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Huang Z,
|
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Qiu W,
|
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Zhang J,
|
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Tian Y,
|
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Yuan Y</span><br />
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<span class="medgenPMjournal">Front Immunol</span>
|
||
2022;13:1062225.
|
||
Epub 2022 Dec 20
|
||
doi: 10.3389/fimmu.2022.1062225.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36605187" target="_blank">36605187</a><a href="/pmc/articles/PMC9808401" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34999237">Metastatic uveal melanoma: The final frontier.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rantala ES,
|
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Hernberg MM,
|
||
Piperno-Neumann S,
|
||
Grossniklaus HE,
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Kivelä TT</span><br />
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<span class="medgenPMjournal">Prog Retin Eye Res</span>
|
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2022 Sep;90:101041.
|
||
Epub 2022 Jan 6
|
||
doi: 10.1016/j.preteyeres.2022.101041.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34999237" target="_blank">34999237</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27911450">Uveal melanoma: relatively rare but deadly cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kaliki S,
|
||
Shields CL</span><br />
|
||
<span class="medgenPMjournal">Eye (Lond)</span>
|
||
2017 Feb;31(2):241-257.
|
||
Epub 2016 Dec 2
|
||
doi: 10.1038/eye.2016.275.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27911450" target="_blank">27911450</a><a href="/pmc/articles/PMC5306463" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Uveal%20melanoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1359)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/37579248">Systemic Therapy for Melanoma: ASCO Guideline Update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Seth R,
|
||
Agarwala SS,
|
||
Messersmith H,
|
||
Alluri KC,
|
||
Ascierto PA,
|
||
Atkins MB,
|
||
Bollin K,
|
||
Chacon M,
|
||
Davis N,
|
||
Faries MB,
|
||
Funchain P,
|
||
Gold JS,
|
||
Guild S,
|
||
Gyorki DE,
|
||
Kaur V,
|
||
Khushalani NI,
|
||
Kirkwood JM,
|
||
McQuade JL,
|
||
Meyers MO,
|
||
Provenzano A,
|
||
Robert C,
|
||
Santinami M,
|
||
Sehdev A,
|
||
Sondak VK,
|
||
Spurrier G,
|
||
Swami U,
|
||
Truong TG,
|
||
Tsai KK,
|
||
van Akkooi A,
|
||
Weber J</span><br />
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||
<span class="medgenPMjournal">J Clin Oncol</span>
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||
2023 Oct 20;41(30):4794-4820.
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||
Epub 2023 Aug 14
|
||
doi: 10.1200/JCO.23.01136.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37579248" target="_blank">37579248</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35941183">Predictors of emotional distress in uveal melanoma survivors: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Davies C,
|
||
Brown SL,
|
||
Fisher P,
|
||
Hope-Stone L,
|
||
Fisher D,
|
||
Morgan A,
|
||
Cherry MG</span><br />
|
||
<span class="medgenPMjournal">Eye (Lond)</span>
|
||
2023 Apr;37(5):907-924.
|
||
Epub 2022 Aug 8
|
||
doi: 10.1038/s41433-022-02193-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35941183" target="_blank">35941183</a><a href="/pmc/articles/PMC10049992" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35262423">Treatment and prophylaxis of radiation optic neuropathy: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yu CW,
|
||
Joarder I,
|
||
Micieli JA</span><br />
|
||
<span class="medgenPMjournal">Eur J Ophthalmol</span>
|
||
2022 Nov;32(6):3129-3141.
|
||
Epub 2022 Mar 9
|
||
doi: 10.1177/11206721221085409.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35262423" target="_blank">35262423</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34431316">Systemic and liver-directed therapies in metastatic uveal melanoma: state-of-the-art and novel perspectives.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Comito F,
|
||
Marchese PV,
|
||
Ricci AD,
|
||
Tober N,
|
||
Peterle C,
|
||
Sperandi F,
|
||
Melotti B</span><br />
|
||
<span class="medgenPMjournal">Future Oncol</span>
|
||
2021 Nov;17(33):4583-4606.
|
||
Epub 2021 Aug 25
|
||
doi: 10.2217/fon-2021-0318.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34431316" target="_blank">34431316</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29219254">Primary bilateral uveal melanoma: a population-based study and systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Scott JF,
|
||
Vyas R,
|
||
Galvin J,
|
||
Gotow E,
|
||
Fiessinger L,
|
||
Gerstenblith AT,
|
||
Gerstenblith MR</span><br />
|
||
<span class="medgenPMjournal">Clin Exp Ophthalmol</span>
|
||
2018 Jul;46(5):502-510.
|
||
Epub 2018 Jan 10
|
||
doi: 10.1111/ceo.13129.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29219254" target="_blank">29219254</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Uveal%20melanoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (41)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
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|
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|
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|
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|
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<div class="supplemental col three_col last">
|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0220633%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0220633%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (3)</a></li>
|
||
<li><a href="/gtr/tests?term=C0220633%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (2)</a></li>
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<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0220633%5bDISCUI%5d" target="_blank">See all (4)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=155720" target="_blank">OMIM</a></li><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=39044" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Uveal%20melanoma" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22uveal%20melanoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Uveal%20melanoma%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/uveal.pdf">NCCN, 2023</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Melanoma: Uveal, 2023</div></li><li><a target="_blank" href="https://www.nice.org.uk/guidance/ng14">NICE, 2022</a><div>UK NICE Guideline NG14, Melanoma: assessment and management, 2022</div></li></ul></div>
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