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<meta name="keywords" content="C0151779, cmm, cutaneous (skin) melanoma, cutaneous malignant melanoma, cutaneous malignant melanomas, cutaneous melanoma, cutaneous melanoma (disease), malignant cutaneous melanoma, malignant ear melanoma, malignant lip melanoma, malignant lower limb melanoma, malignant melanoma (of skin), stage unspecified, malignant melanoma of ear and/or external auricular canal, malignant melanoma of skin, malignant melanoma of skin of lower limb, malignant melanoma of skin of trunk except scrotum, malignant melanoma of skin of upper limb, malignant melanoma of skin stage unspecified, malignant melanoma, cutaneous, malignant melanoma, somatic, malignant melanomas, cutaneous, malignant neck melanoma, malignant scalp melanoma, malignant trunk melanoma, malignant upper limb melanoma, melanoma (disease) of zone of skin, melanoma of skin, melanoma of the skin, melanoma, cutaneous malignant, melanoma, malignant, melanomas, cutaneous malignant, mm (malignant melanoma) of skin, neoplastic process, skin melanoma, skin, melanoma, zone of skin melanoma, zone of skin melanoma (disease), autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Most melanomas affect only the outermost layer of skin (the epidermis). If a melanoma becomes thicker and involves multiple layers of skin, it can spread to other parts of the body (metastasize).\n\nA large number of moles or other pigmented skin growths on the body, generally more than 25, is associated with an increased risk of developing melanoma. Melanoma is also a common feature of genetic syndromes affecting the skin such as xeroderma pigmentosum. Additionally, individuals who have previously had melanoma are nearly nine times more likely than the general population to develop melanoma again. It is estimated that about 90 percent of individuals with melanoma survive at least 5 years after being diagnosed.\n\nMelanoma may develop from an existing mole or other normal skin growth that becomes cancerous (malignant); however, many melanomas are new growths. Melanomas often have ragged edges and an irregular shape. They can range from a few millimeters to several centimeters across. They can also be a variety of colors: brown, black, red, pink, blue, or white.\n\nMelanoma is a type of skin cancer that begins in pigment-producing cells called melanocytes. This cancer typically occurs in areas that are only occasionally sun-exposed; tumors are most commonly found on the back in men and on the legs in women. Melanoma usually occurs on the skin (cutaneous melanoma), but in about 5 percent of cases it develops in melanocytes in other tissues, including the eyes (uveal melanoma) or mucous membranes that line the body's cavities, such as the moist lining of the mouth (mucosal melanoma). Melanoma can develop at any age, but it most frequently occurs in people in their fifties to seventies and is becoming more common in teenagers and young adults." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
|
||
UID=57486
|
||
ConceptID=C0151779
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Malignant melanoma of skin<span class="h1sub">(CMM)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>57486</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0151779</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>CMM; Cutaneous Malignant Melanoma; Cutaneous melanoma; Malignant melanoma, somatic</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Cutaneous malignant melanoma (93655004); Malignant melanoma of skin (93655004); Melanoma of skin (93655004); MM (malignant melanoma) of skin (93655004)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help" data-jig="ncbipopper" href="#target-gene-related">Related genes:<img src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div id="target-gene-related" class="display-none">
|
||
Gene(s) associated with related conditions. For conditions<br />
|
||
in a hierarchy, the parent condition will list the genes<br />
|
||
associated with the children conditions.</div></td>
|
||
<td><a target="_blank" href="/gene/7517">XRCC3</a>, <a target="_blank" href="/gene/7015">TERT</a>, <a target="_blank" href="/gene/6794">STK11</a>, <a target="_blank" href="/gene/4286">MITF</a>, <a target="_blank" href="/gene/4157">MC1R</a>, <a target="_blank" href="/gene/1029">CDKN2A</a>, <a target="_blank" href="/gene/1019">CDK4</a>, <a target="_blank" href="/gene/673">BRAF</a></td></tr><tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0012056">HP:0012056</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0005012" target="_blank">MONDO:0005012</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/155600" target="_blank">155600</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Most melanomas affect only the outermost layer of skin (the epidermis). If a melanoma becomes thicker and involves multiple layers of skin, it can spread to other parts of the body (metastasize).<br /><br />A large number of moles or other pigmented skin growths on the body, generally more than 25, is associated with an increased risk of developing melanoma. Melanoma is also a common feature of genetic syndromes affecting the skin such as xeroderma pigmentosum. Additionally, individuals who have previously had melanoma are nearly nine times more likely than the general population to develop melanoma again. It is estimated that about 90 percent of individuals with melanoma survive at least 5 years after being diagnosed.<br /><br />Melanoma may develop from an existing mole or other normal skin growth that becomes cancerous (malignant); however, many melanomas are new growths. Melanomas often have ragged edges and an irregular shape. They can range from a few millimeters to several centimeters across. They can also be a variety of colors: brown, black, red, pink, blue, or white.<br /><br />Melanoma is a type of skin cancer that begins in pigment-producing cells called melanocytes. This cancer typically occurs in areas that are only occasionally sun-exposed; tumors are most commonly found on the back in men and on the legs in women. Melanoma usually occurs on the skin (cutaneous melanoma), but in about 5 percent of cases it develops in melanocytes in other tissues, including the eyes (uveal melanoma) or mucous membranes that line the body's cavities, such as the moist lining of the mouth (mucosal melanoma). Melanoma can develop at any age, but it most frequently occurs in people in their fifties to seventies and is becoming more common in teenagers and young adults. [from <a title="MedlinePlus Genetics" href="https://medlineplus.gov/genetics/" class="defSource" target="_blank">MedlinePlus Genetics</a>]</div>
|
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</div>
|
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|
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<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0025202[DISCUI]&test_type=Clinical" ref="ncbi_uid=9944">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=9944" ref="ncbi_uid=9944">V</a></span></span><span class="TLline"><a href="/medgen/9944" ref="tree=GTR&ncbi_uid=9944&link_uid=9944" title="View MedGen record for 'Melanoma'">Melanoma</a></span><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0151779[DISCUI]&test_type=Clinical" ref="ncbi_uid=57486">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=57486" target="_blank" href="/omim/155600">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=57486" ref="ncbi_uid=57486">V</a></span></span><span class="TLline">Malignant melanoma of skin</span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1512419[DISCUI]&test_type=Clinical" ref="ncbi_uid=268851">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=268851" ref="ncbi_uid=268851">V</a></span></span><span class="TLline"><a href="/medgen/268851" ref="tree=GTR&ncbi_uid=268851&link_uid=268851" title="View MedGen record for 'Familial melanoma'">Familial melanoma</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1835047[DISCUI]&test_type=Clinical" ref="ncbi_uid=320506">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=320506" target="_blank" href="/omim/155600">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=320506" ref="ncbi_uid=320506">V</a></span></span><span class="TLline"><a href="/medgen/320506" ref="tree=GTR&ncbi_uid=320506&link_uid=320506" title="View MedGen record for 'Melanoma, cutaneous malignant, susceptibility to, 1'">Melanoma, cutaneous malignant, susceptibility to, 1</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1835044[DISCUI]&test_type=Clinical" ref="ncbi_uid=331891">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=331891" target="_blank" href="/omim/155601">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=331891" ref="ncbi_uid=331891">V</a></span></span><span class="TLline"><a href="/medgen/331891" ref="tree=GTR&ncbi_uid=331891&link_uid=331891" title="View MedGen record for 'Melanoma, cutaneous malignant, susceptibility to, 2'">Melanoma, cutaneous malignant, susceptibility to, 2</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1836892[DISCUI]&test_type=Clinical" ref="ncbi_uid=373202">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=373202" target="_blank" href="/omim/123829">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=373202" ref="ncbi_uid=373202">V</a></span></span><span class="TLline"><a href="/medgen/373202" ref="tree=GTR&ncbi_uid=373202&link_uid=373202" title="View MedGen record for 'Melanoma, cutaneous malignant, susceptibility to, 3'">Melanoma, cutaneous malignant, susceptibility to, 3</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=334129" target="_blank" href="/omim/608035">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/334129" ref="tree=GTR&ncbi_uid=334129&link_uid=334129" title="View MedGen record for 'Melanoma, cutaneous malignant, susceptibility to, 4'">Melanoma, cutaneous malignant, susceptibility to, 4</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2751295[DISCUI]&test_type=Clinical" ref="ncbi_uid=416516">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=416516" target="_blank" href="/omim/155555">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=416516" ref="ncbi_uid=416516">V</a></span></span><span class="TLline"><a href="/medgen/416516" ref="tree=GTR&ncbi_uid=416516&link_uid=416516" title="View MedGen record for 'Melanoma, cutaneous malignant, susceptibility to, 5'">Melanoma, cutaneous malignant, susceptibility to, 5</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3151417[DISCUI]&test_type=Clinical" ref="ncbi_uid=462767">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=462767" target="_blank" href="/omim/600675">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=462767" ref="ncbi_uid=462767">V</a></span></span><span class="TLline"><a href="/medgen/462767" ref="tree=GTR&ncbi_uid=462767&link_uid=462767" title="View MedGen record for 'Melanoma, cutaneous malignant, susceptibility to, 6'">Melanoma, cutaneous malignant, susceptibility to, 6</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=394200" target="_blank" href="/omim/612263">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/394200" ref="tree=GTR&ncbi_uid=394200&link_uid=394200" title="View MedGen record for 'Melanoma, cutaneous malignant, susceptibility to, 7'">Melanoma, cutaneous malignant, susceptibility to, 7</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3152204[DISCUI]&test_type=Clinical" ref="ncbi_uid=463554">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=463554" target="_blank" href="/omim/156845">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=463554" ref="ncbi_uid=463554">V</a></span></span><span class="TLline"><a href="/medgen/463554" ref="tree=GTR&ncbi_uid=463554&link_uid=463554" title="View MedGen record for 'Melanoma, cutaneous malignant, susceptibility to, 8'">Melanoma, cutaneous malignant, susceptibility to, 8</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3554574[DISCUI]&test_type=Clinical" ref="ncbi_uid=767488">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=767488" target="_blank" href="/omim/187270">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=767488" ref="ncbi_uid=767488">V</a></span></span><span class="TLline"><a href="/medgen/767488" ref="tree=GTR&ncbi_uid=767488&link_uid=767488" title="View MedGen record for 'Melanoma, cutaneous malignant, susceptibility to, 9'">Melanoma, cutaneous malignant, susceptibility to, 9</a></span></li></ul></li></ul></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/14297" ref="tree=MeSH" title="MedGen record for Malignant neoplastic disease">Malignant neoplastic disease</a></span><ul><li><span class="TLline"><a href="/medgen/40101" ref="tree=MeSH" title="MedGen record for Malignant neoplasm of skin">Malignant neoplasm of skin</a></span><ul><li><span class="matched_ds">Malignant melanoma of skin</span><ul><li><span class="TLline"><a href="/medgen/87530" ref="tree=MeSH" title="MedGen record for Acral lentiginous melanoma">Acral lentiginous melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/1792122" ref="tree=MeSH" title="MedGen record for Metastatic Acral Lentiginous Melanoma">Metastatic Acral Lentiginous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1779376" ref="tree=MeSH" title="MedGen record for Recurrent Acral Lentiginous Melanoma">Recurrent Acral Lentiginous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1612231" ref="tree=MeSH" title="MedGen record for Stage I Acral Lentiginous Melanoma AJCC v7">Stage I Acral Lentiginous Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1615652" ref="tree=MeSH" title="MedGen record for Stage II Acral Lentiginous Melanoma AJCC v6 and v7">Stage II Acral Lentiginous Melanoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1619986" ref="tree=MeSH" title="MedGen record for Stage III Acral Lentiginous Melanoma AJCC v7">Stage III Acral Lentiginous Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1619912" ref="tree=MeSH" title="MedGen record for Stage IV Acral Lentiginous Melanoma AJCC v6 and v7">Stage IV Acral Lentiginous Melanoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1713937" ref="tree=MeSH" title="MedGen record for Unresectable Acral Lentiginous Melanoma">Unresectable Acral Lentiginous Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/91149" ref="tree=MeSH" title="MedGen record for Amelanotic skin melanoma">Amelanotic skin melanoma</a></span></li><li><span class="TLline"><a href="/medgen/90780" ref="tree=MeSH" title="MedGen record for Balloon cell malignant melanoma">Balloon cell malignant melanoma</a></span></li><li><span class="TLline"><a href="/medgen/455940" ref="tree=MeSH" title="MedGen record for Cutaneous Melanoma by AJCC v6 Stage">Cutaneous Melanoma by AJCC v6 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1615151" ref="tree=MeSH" title="MedGen record for Stage 0 Cutaneous Melanoma AJCC v6 and v7">Stage 0 Cutaneous Melanoma AJCC v6 and v7</a></span><ul><li><span class="TLline"><a href="/medgen/57443" ref="tree=MeSH" title="MedGen record for Lentigo Maligna">Lentigo Maligna</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/75887" ref="tree=MeSH" title="MedGen record for Stage I Cutaneous Melanoma AJCC v6">Stage I Cutaneous Melanoma AJCC v6</a></span></li><li><span class="TLline"><a href="/medgen/1619901" ref="tree=MeSH" title="MedGen record for Stage II Cutaneous Melanoma AJCC v6 and v7">Stage II Cutaneous Melanoma AJCC v6 and v7</a></span><ul><li><span class="TLline"><a href="/medgen/1624279" ref="tree=MeSH" title="MedGen record for Stage II Lentigo Maligna Melanoma AJCC v6 and v7">Stage II Lentigo Maligna Melanoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1617874" ref="tree=MeSH" title="MedGen record for Stage II Low-CSD Melanoma AJCC v7">Stage II Low-CSD Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/415724" ref="tree=MeSH" title="MedGen record for Stage IIA Cutaneous Melanoma AJCC v6 and v7">Stage IIA Cutaneous Melanoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/234832" ref="tree=MeSH" title="MedGen record for Stage IIB Cutaneous Melanoma AJCC v6 and v7">Stage IIB Cutaneous Melanoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/417853" ref="tree=MeSH" title="MedGen record for Stage IIC Cutaneous Melanoma AJCC v6 and v7">Stage IIC Cutaneous Melanoma AJCC v6 and v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/83001" ref="tree=MeSH" title="MedGen record for Stage III Cutaneous Melanoma AJCC v6">Stage III Cutaneous Melanoma AJCC v6</a></span></li><li><span class="TLline"><a href="/medgen/1611450" ref="tree=MeSH" title="MedGen record for Stage IV Cutaneous Melanoma AJCC v6 and v7">Stage IV Cutaneous Melanoma AJCC v6 and v7</a></span><ul><li><span class="TLline"><a href="/medgen/1622988" ref="tree=MeSH" title="MedGen record for Stage IV Lentigo Maligna Melanoma AJCC v6 and v7">Stage IV Lentigo Maligna Melanoma AJCC v6 and v7</a></span></li><li><span class="TLline"><a href="/medgen/1626104" ref="tree=MeSH" title="MedGen record for Stage IV Low-CSD Melanoma AJCC v7">Stage IV Low-CSD Melanoma AJCC v7</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/456322" ref="tree=MeSH" title="MedGen record for Cutaneous Melanoma by AJCC v7 Stage">Cutaneous Melanoma by AJCC v7 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/454152" ref="tree=MeSH" title="MedGen record for Stage I Cutaneous Melanoma AJCC v7">Stage I Cutaneous Melanoma AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/1618889" ref="tree=MeSH" title="MedGen record for Stage I Lentigo Maligna Melanoma AJCC v7">Stage I Lentigo Maligna Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1616942" ref="tree=MeSH" title="MedGen record for Stage I Low-CSD Melanoma AJCC v7">Stage I Low-CSD Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/443628" ref="tree=MeSH" title="MedGen record for Stage IA Cutaneous Melanoma AJCC v7">Stage IA Cutaneous Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/417852" ref="tree=MeSH" title="MedGen record for Stage IB Cutaneous Melanoma AJCC v7">Stage IB Cutaneous Melanoma AJCC v7</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/454153" ref="tree=MeSH" title="MedGen record for Stage III Cutaneous Melanoma AJCC v7">Stage III Cutaneous Melanoma AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/1622857" ref="tree=MeSH" title="MedGen record for Stage III Lentigo Maligna Melanoma AJCC v7">Stage III Lentigo Maligna Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/1625334" ref="tree=MeSH" title="MedGen record for Stage III Low-CSD Melanoma AJCC v7">Stage III Low-CSD Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/443629" ref="tree=MeSH" title="MedGen record for Stage IIIA Cutaneous Melanoma AJCC v7">Stage IIIA Cutaneous Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/416126" ref="tree=MeSH" title="MedGen record for Stage IIIB Cutaneous Melanoma AJCC v7">Stage IIIB Cutaneous Melanoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/443630" ref="tree=MeSH" title="MedGen record for Stage IIIC Cutaneous Melanoma AJCC v7">Stage IIIC Cutaneous Melanoma AJCC v7</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1627083" ref="tree=MeSH" title="MedGen record for Cutaneous Melanoma by AJCC v8 Stage">Cutaneous Melanoma by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1612630" ref="tree=MeSH" title="MedGen record for Cutaneous Melanoma by AJCC v8 Clinical Stage">Cutaneous Melanoma by AJCC v8 Clinical Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1625435" ref="tree=MeSH" title="MedGen record for Clinical Stage 0 Cutaneous Melanoma AJCC v8">Clinical Stage 0 Cutaneous Melanoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1626826" ref="tree=MeSH" title="MedGen record for Clinical Stage I Cutaneous Melanoma AJCC v8">Clinical Stage I Cutaneous Melanoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1619695" ref="tree=MeSH" title="MedGen record for Clinical Stage II Cutaneous Melanoma AJCC v8">Clinical Stage II Cutaneous Melanoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1625027" ref="tree=MeSH" title="MedGen record for Clinical Stage III Cutaneous Melanoma AJCC v8">Clinical Stage III Cutaneous Melanoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1622934" ref="tree=MeSH" title="MedGen record for Clinical Stage IV Cutaneous Melanoma AJCC v8">Clinical Stage IV Cutaneous Melanoma AJCC v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1615907" ref="tree=MeSH" title="MedGen record for Cutaneous Melanoma by AJCC v8 Pathologic Stage">Cutaneous Melanoma by AJCC v8 Pathologic Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1623642" ref="tree=MeSH" title="MedGen record for Pathologic Stage 0 Cutaneous Melanoma AJCC v8">Pathologic Stage 0 Cutaneous Melanoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1621782" ref="tree=MeSH" title="MedGen record for Pathologic Stage I Cutaneous Melanoma AJCC v8">Pathologic Stage I Cutaneous Melanoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1615825" ref="tree=MeSH" title="MedGen record for Pathologic Stage II Cutaneous Melanoma AJCC v8">Pathologic Stage II Cutaneous Melanoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1626911" ref="tree=MeSH" title="MedGen record for Pathologic Stage III Cutaneous Melanoma AJCC v8">Pathologic Stage III Cutaneous Melanoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1616225" ref="tree=MeSH" title="MedGen record for Pathologic Stage IV Cutaneous Melanoma AJCC v8">Pathologic Stage IV Cutaneous Melanoma AJCC v8</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1664542" ref="tree=MeSH" title="MedGen record for Cutaneous Melanoma of the Extremity">Cutaneous Melanoma of the Extremity</a></span><ul><li><span class="TLline"><a href="/medgen/1666275" ref="tree=MeSH" title="MedGen record for Advanced Cutaneous Melanoma of the Extremity">Advanced Cutaneous Melanoma of the Extremity</a></span></li><li><span class="TLline"><a href="/medgen/1657275" ref="tree=MeSH" title="MedGen record for Recurrent Cutaneous Melanoma of the Extremity">Recurrent Cutaneous Melanoma of the Extremity</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/268851" ref="tree=MeSH" title="MedGen record for Familial melanoma">Familial melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/924394" ref="tree=MeSH" title="MedGen record for Cutaneous Malignant Melanoma 2">Cutaneous Malignant Melanoma 2</a></span></li><li><span class="TLline"><a href="/medgen/320506" ref="tree=MeSH" title="MedGen record for Melanoma, cutaneous malignant, susceptibility to, 1">Melanoma, cutaneous malignant, susceptibility to, 1</a></span></li><li><span class="TLline"><a href="/medgen/331891" ref="tree=MeSH" title="MedGen record for Melanoma, cutaneous malignant, susceptibility to, 2">Melanoma, cutaneous malignant, susceptibility to, 2</a></span></li><li><span class="TLline"><a href="/medgen/373202" ref="tree=MeSH" title="MedGen record for Melanoma, cutaneous malignant, susceptibility to, 3">Melanoma, cutaneous malignant, susceptibility to, 3</a></span></li><li><span class="TLline"><a href="/medgen/334129" ref="tree=MeSH" title="MedGen record for Melanoma, cutaneous malignant, susceptibility to, 4">Melanoma, cutaneous malignant, susceptibility to, 4</a></span></li><li><span class="TLline"><a href="/medgen/416516" ref="tree=MeSH" title="MedGen record for Melanoma, cutaneous malignant, susceptibility to, 5">Melanoma, cutaneous malignant, susceptibility to, 5</a></span></li><li><span class="TLline"><a href="/medgen/462767" ref="tree=MeSH" title="MedGen record for Melanoma, cutaneous malignant, susceptibility to, 6">Melanoma, cutaneous malignant, susceptibility to, 6</a></span></li><li><span class="TLline"><a href="/medgen/394200" ref="tree=MeSH" title="MedGen record for Melanoma, cutaneous malignant, susceptibility to, 7">Melanoma, cutaneous malignant, susceptibility to, 7</a></span></li><li><span class="TLline"><a href="/medgen/463554" ref="tree=MeSH" title="MedGen record for Melanoma, cutaneous malignant, susceptibility to, 8">Melanoma, cutaneous malignant, susceptibility to, 8</a></span></li><li><span class="TLline"><a href="/medgen/767488" ref="tree=MeSH" title="MedGen record for Melanoma, cutaneous malignant, susceptibility to, 9">Melanoma, cutaneous malignant, susceptibility to, 9</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1719520" ref="tree=MeSH" title="MedGen record for High-CSD Melanoma">High-CSD Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/232127" ref="tree=MeSH" title="MedGen record for Desmoplastic melanoma">Desmoplastic melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/311047" ref="tree=MeSH" title="MedGen record for Desmoplastic Neurotropic Melanoma">Desmoplastic Neurotropic Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/439437" ref="tree=MeSH" title="MedGen record for Lentigo maligna melanoma">Lentigo maligna melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/208941" ref="tree=MeSH" title="MedGen record for Recurrent Lentigo Maligna Melanoma">Recurrent Lentigo Maligna Melanoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/310892" ref="tree=MeSH" title="MedGen record for Invasive Cutaneous Melanoma">Invasive Cutaneous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/96555" ref="tree=MeSH" title="MedGen record for Malignant Melanoma in Precancerous Melanosis">Malignant Melanoma in Precancerous Melanosis</a></span></li><li><span class="TLline"><a href="/medgen/83150" ref="tree=MeSH" title="MedGen record for Melanoma Arising from Blue Nevus">Melanoma Arising from Blue Nevus</a></span></li><li><span class="TLline"><a href="/medgen/313976" ref="tree=MeSH" title="MedGen record for Melanoma in congenital melanocytic nevus">Melanoma in congenital melanocytic nevus</a></span><ul><li><span class="TLline"><a href="/medgen/569664" ref="tree=MeSH" title="MedGen record for Melanoma Arising in Giant Congenital Nevus">Melanoma Arising in Giant Congenital Nevus</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/90782" ref="tree=MeSH" title="MedGen record for Melanoma in Junctional Nevus">Melanoma in Junctional Nevus</a></span></li><li><span class="TLline"><a href="/medgen/272113" ref="tree=MeSH" title="MedGen record for Metastatic Cutaneous Melanoma">Metastatic Cutaneous Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/1728947" ref="tree=MeSH" title="MedGen record for Advanced Cutaneous Melanoma">Advanced Cutaneous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1723072" ref="tree=MeSH" title="MedGen record for Locally Advanced Cutaneous Melanoma">Locally Advanced Cutaneous Melanoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/108173" ref="tree=MeSH" title="MedGen record for Minimal Deviation Melanoma">Minimal Deviation Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/406940" ref="tree=MeSH" title="MedGen record for Nevoid Melanoma">Nevoid Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/83144" ref="tree=MeSH" title="MedGen record for Nodular malignant melanoma">Nodular malignant melanoma</a></span></li><li><span class="TLline"><a href="/medgen/233263" ref="tree=MeSH" title="MedGen record for Old Burn Scar-Related Cutaneous Melanoma">Old Burn Scar-Related Cutaneous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1791543" ref="tree=MeSH" title="MedGen record for Penile Cutaneous Melanoma">Penile Cutaneous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/83003" ref="tree=MeSH" title="MedGen record for Recurrent Melanoma">Recurrent Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/235541" ref="tree=MeSH" title="MedGen record for Recurrent Non-Cutaneous Melanoma">Recurrent Non-Cutaneous Melanoma</a></span><ul><li><span class="TLline"><a href="/medgen/1730067" ref="tree=MeSH" title="MedGen record for Recurrent Mucosal Melanoma">Recurrent Mucosal Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1759355" ref="tree=MeSH" title="MedGen record for Recurrent Ocular Melanoma">Recurrent Ocular Melanoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1667902" ref="tree=MeSH" title="MedGen record for Refractory Cutaneous Melanoma">Refractory Cutaneous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/233917" ref="tree=MeSH" title="MedGen record for Regressing Cutaneous Melanoma">Regressing Cutaneous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/233100" ref="tree=MeSH" title="MedGen record for Scrotum melanoma">Scrotum melanoma</a></span></li><li><span class="TLline"><a href="/medgen/407978" ref="tree=MeSH" title="MedGen record for Signet Ring Melanoma">Signet Ring Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/234797" ref="tree=MeSH" title="MedGen record for Solar Radiation-Related Cutaneous Melanoma">Solar Radiation-Related Cutaneous Melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1713307" ref="tree=MeSH" title="MedGen record for Spitzoid melanoma">Spitzoid melanoma</a></span></li><li><span class="TLline"><a href="/medgen/87242" ref="tree=MeSH" title="MedGen record for Superficial spreading melanoma">Superficial spreading melanoma</a></span></li><li><span class="TLline"><a href="/medgen/1662307" ref="tree=MeSH" title="MedGen record for Unresectable Cutaneous Melanoma">Unresectable Cutaneous Melanoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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<div class="divPopper rprt" id="rdis_78643"><div><strong>Xeroderma pigmentosum group B</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>78643</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268136</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Xeroderma pigmentosum (XP) is characterized by: Acute sun sensitivity (severe sunburn with blistering, persistent erythema on minimal sun exposure) with marked freckle-like pigmentation of the face before age two years; Sunlight-induced ocular involvement (photophobia, severe keratitis, atrophy of the skin of the lids, ocular surface neoplasms); Greatly increased risk of sunlight-induced cutaneous neoplasms (basal cell carcinoma, squamous cell carcinoma, melanoma) within the first decade of life. Approximately 25% of affected individuals have neurologic manifestations (acquired microcephaly, diminished or absent deep tendon stretch reflexes, progressive sensorineural hearing loss, progressive cognitive impairment, and ataxia). The most common causes of death are skin cancer, neurologic degeneration, and internal cancer. The median age at death in persons with XP with neurodegeneration (29 years) was found to be younger than that in persons with XP without neurodegeneration (37 years).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/78643">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_331890"><div><strong>Melanoma and neural system tumor syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>331890</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1835042</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">The melanoma-astrocytoma syndrome is an autosomal dominant disorder characterized by a dual predisposition to melanoma and neural system tumors, commonly astrocytoma. In families with this disorder, patients with melanoma have a higher risk of developing neural system tumors, and this increased risk extends to both first and second degree relatives (summary by Randerson-Moor et al., 2001).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/331890">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_331891"><div><strong>Melanoma, cutaneous malignant, susceptibility to, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>331891</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1835044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Malignant melanoma is a neoplasm of pigment-producing cells called melanocytes that occurs most often in the skin, but may also occur in the eyes, ears, gastrointestinal tract, leptomeninges, and oral and genital mucous membranes (summary by Habif, 2010). For a discussion of genetic heterogeneity of cutaneous malignant melanoma, see CMM1 (155600).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/331891">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_320506"><div><strong>Melanoma, cutaneous malignant, susceptibility to, 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>320506</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1835047</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Malignant melanoma is a neoplasm of pigment-producing cells called melanocytes that occurs most often in the skin, but may also occur in the eyes, ears, gastrointestinal tract, leptomeninges, and oral and genital mucous membranes (summary by Habif, 2010). Genetic Heterogeneity of Susceptibility to Cutaneous Malignant Melanoma The locus for susceptibility to familial cutaneous malignant melanoma-1 (CMM1) has been mapped to chromosome 1p36. Other CMM susceptibility loci include CMM2 (155601), caused by variation in the CDKN2A gene (600160) on chromosome 9p21; CMM3 (609048), caused by variation in the CDK4 gene (123829) on chromosome 12q14; CMM4 (608035), mapped to chromosome 1p22; CMM5 (613099), caused by variation in the MC1R gene (155555) on chromosome 16q24; CMM6 (613972), caused by variation in the XRCC3 gene (600675) on chromosome 14q32; CMM7 (612263), mapped to chromosome 20q11; CMM8 (614456), caused by variation in the MITF gene (156845) on chromosome 3p13; CMM9 (615134), caused by variation in the TERT gene (187270) on chromosome 5p15; and CMM10 (615848), caused by mutation in the POT1 gene (606478) on chromosome 7q31. Somatic mutations causing malignant melanoma have also been identified in several genes, including BRAF (164757), STK11 (602216), PTEN (601728), TRRAP (603015), DCC (120470), GRIN2A (138253), ZNF831, BAP1 (603089), and RASA2 (601589). A large percentage of melanomas (40-60%) carry an activating somatic mutation in the BRAF gene, most often V600E (164757.0001) (Davies et al., 2002; Pollock et al., 2003).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/320506">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_373202"><div><strong>Melanoma, cutaneous malignant, susceptibility to, 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>373202</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1836892</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Malignant melanoma is a neoplasm of pigment-producing cells called melanocytes that occurs most often in the skin, but may also occur in the eyes, ears, gastrointestinal tract, leptomeninges, and oral and genital mucous membranes (summary by Habif, 2010). For a discussion of genetic heterogeneity of malignant melanoma, see 155600.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/373202">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_330752"><div><strong>Large congenital melanocytic nevus</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>330752</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1842036</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">Congenital melanocytic nevus syndrome is characterized by pigmentary skin defects apparent at birth. Most individuals have 1 or more large or giant lesions greater than 20 cm and up to over 60 cm in diameter, which may cover up to 80% of total body area. These lesions may or may not be hairy. Smaller 'satellite' pigmented lesions numbering in the hundreds may also be present all over the body. Congenital melanocytic nevi (CMN) can be associated with malignant melanoma (see CMM1, 155600), but the risk appears to be low, ranging from 1 to 2% for all individuals, but rising to 10 to 15% in those with very large nevi (greater than 40 cm). A small subset of patients with CMNS have abnormalities of the central nervous system, known as 'neurocutaneous melanosis' or 'neuromelanosis' (249400), which may be symptomatic. Patients with CMNS also tend to have a characteristic facial appearance, including wide or prominent forehead, periorbital fullness, small short nose with narrow nasal bridge, round face, full cheeks, prominent premaxilla, and everted lower lip (summary by Kinsler et al., 2008; Kinsler et al., 2012). Spitz nevi are benign melanocytic melanomas composed of epithelioid or spindle cell melanocytes. They usually present as solitary skin tumors but can occur in multiple patterns, having agminated, dermatomal, and disseminated forms (summary by Sarin et al., 2013). Nevus spilus, also known as speckled lentiginous nevus, is a congenital hyperpigmented patch that progressively evolves, with affected individuals developing dark macules and papules during childhood and adolescence. Over time, nevus spilus may give rise to common lentigines, melanocytic nevi, Spitz nevi, and melanomas (summary by Sarin et al., 2014).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/330752">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_376352"><div><strong>Xeroderma pigmentosum variant type</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>376352</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1848410</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Xeroderma pigmentosum (XP) is characterized by: Acute sun sensitivity (severe sunburn with blistering, persistent erythema on minimal sun exposure) with marked freckle-like pigmentation of the face before age two years; Sunlight-induced ocular involvement (photophobia, severe keratitis, atrophy of the skin of the lids, ocular surface neoplasms); Greatly increased risk of sunlight-induced cutaneous neoplasms (basal cell carcinoma, squamous cell carcinoma, melanoma) within the first decade of life. Approximately 25% of affected individuals have neurologic manifestations (acquired microcephaly, diminished or absent deep tendon stretch reflexes, progressive sensorineural hearing loss, progressive cognitive impairment, and ataxia). The most common causes of death are skin cancer, neurologic degeneration, and internal cancer. The median age at death in persons with XP with neurodegeneration (29 years) was found to be younger than that in persons with XP without neurodegeneration (37 years).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/376352">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_416702"><div><strong>Xeroderma pigmentosum, group C</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>416702</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2752147</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Xeroderma pigmentosum (XP) is characterized by: Acute sun sensitivity (severe sunburn with blistering, persistent erythema on minimal sun exposure) with marked freckle-like pigmentation of the face before age two years; Sunlight-induced ocular involvement (photophobia, severe keratitis, atrophy of the skin of the lids, ocular surface neoplasms); Greatly increased risk of sunlight-induced cutaneous neoplasms (basal cell carcinoma, squamous cell carcinoma, melanoma) within the first decade of life. Approximately 25% of affected individuals have neurologic manifestations (acquired microcephaly, diminished or absent deep tendon stretch reflexes, progressive sensorineural hearing loss, progressive cognitive impairment, and ataxia). The most common causes of death are skin cancer, neurologic degeneration, and internal cancer. The median age at death in persons with XP with neurodegeneration (29 years) was found to be younger than that in persons with XP without neurodegeneration (37 years).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/416702">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_463554"><div><strong>Melanoma, cutaneous malignant, susceptibility to, 8</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>463554</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3152204</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
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<div class="spaceAbove">Malignant melanoma is a neoplasm of pigment-producing cells called melanocytes that occurs most often in the skin, but may also occur in the eyes, ears, gastrointestinal tract, leptomeninges, and oral and genital mucous membranes (summary by Habif, 2010). For a discussion of genetic heterogeneity of cutaneous malignant melanoma, see CMM1 (155600).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/463554">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_482122"><div><strong>BAP1-related tumor predisposition syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482122</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3280492</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">BAP1 tumor predisposition syndrome (BAP1-TPDS) is associated with an increased risk for a specific skin lesion, BAP1-inactivated melanocytic tumors (BIMT; formerly called atypical Spitz tumors), and the following cancers, in descending order of frequency: uveal (eye) melanoma (UM), malignant mesothelioma (MMe), cutaneous melanoma (CM), renal cell carcinoma (RCC), basal cell carcinoma (BCC), meningioma, and cholangiocarcinoma. Onychopapillomas, hepatocellular carcinoma, and ovarian sex cord-stromal tumors may also be associated with BAP1-TPDS. Affected individuals can have more than one type of primary cancer. In general, the median age of onset of these tumors is younger than in the general population. UM tends to be a more aggressive class 2 tumor with higher risk for metastasis and reduced survival compared to UM occurring in the general population. RCC is usually of clear cell morphology, but other pathologies have been reported. MMe, especially pleural, has better survival and responds better to platinum chemotherapy than MMe not associated with a germline BAP1 pathogenic variant. The penetrance, natural history, life-time cancer risk for carriers, and frequencies of BAP1-associated tumors are yet to be fully determined.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/482122">Condition Record</a></div></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482122" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">BAP1-related tumor predisposition syndrome</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_330752" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Large congenital melanocytic nevus</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_331890" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Melanoma and neural system tumor syndrome</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_320506" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Melanoma, cutaneous malignant, susceptibility to, 1</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_331891" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Melanoma, cutaneous malignant, susceptibility to, 2</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (10)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_373202" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Melanoma, cutaneous malignant, susceptibility to, 3</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_463554" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Melanoma, cutaneous malignant, susceptibility to, 8</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_78643" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Xeroderma pigmentosum group B</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_376352" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Xeroderma pigmentosum variant type</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_416702" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Xeroderma pigmentosum, group C</a></div></span></div></div>
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</div>
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<div class="portlet mgSection" id="ID_105">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
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<div class="nl"><a target="_blank" href="/pubmed/23724697">Factors significantly increasing or inhibiting early stages of malignant melanoma (M.M.) and non-invasive evaluation of new treatment by ingestion and external application of optimal doses of the most effective anti-M.M. substances: haritaki, cilantro, vitamin D3, nori, EPA with DHA, & application of special (+) solar energy stored paper, which reduced the M.M. active area & asbestos rapidly.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Omura Y,
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Jones M,
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Duvvi H,
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Paluch K,
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Shimotsuura Y,
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Ohki M</span><br />
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<span class="medgenPMjournal">Acupunct Electrother Res</span>
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2013;38(1-2):37-76.
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doi: 10.3727/036012913x13831831849484.
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<span class="bold">PMID: </span><a href="/pubmed/23724697" target="_blank">23724697</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22malignant%20melanoma%20of%20skin%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/cutaneous_melanoma.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Melanoma: Cutaneous, 2024</a></h3>
|
||
<h3 class="nl vspace"><a href="https://www.nice.org.uk/guidance/ng14" target="_blank">UK NICE Guideline NG14, Melanoma: assessment and management, 2022</a></h3>
|
||
<h3 class="nl vspace"><a href="http://www.nice.org.uk/guidance/ta269/chapter/guidance" target="_blank">Vemurafenib for treating locally advanced or metastatic BRAF V600 mutation-positive malignant melanoma (Updated 1 January 2015)</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38741062">Causal inference between pernicious anemia and cancers: a bidirectional two-sample mendelian randomization analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Che B,
|
||
Yuan S,
|
||
Zhang H,
|
||
Zhai J,
|
||
Zhang Y,
|
||
Wu C,
|
||
Tang K</span><br />
|
||
<span class="medgenPMjournal">BMC Cancer</span>
|
||
2024 May 13;24(1):586.
|
||
doi: 10.1186/s12885-024-12354-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38741062" target="_blank">38741062</a><a href="/pmc/articles/PMC11092143" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34323875">Clinical Outcomes of Free, Public Skin Cancer Screening Events, Rhode Island, 2015-2019.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee KC,
|
||
Fulton JP,
|
||
Kazemi L,
|
||
George EA,
|
||
Smith CK,
|
||
Andoscia G,
|
||
Kawaoka JC,
|
||
Almeida-DoRosario A</span><br />
|
||
<span class="medgenPMjournal">R I Med J (2013)</span>
|
||
2021 Aug 2;104(6):22-27.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34323875" target="_blank">34323875</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25436472">Epidemiology of cancers in Serbia and possible connection with cyanobacterial blooms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Svirčev Z,
|
||
Drobac D,
|
||
Tokodi N,
|
||
Lužanin Z,
|
||
Munjas AM,
|
||
Nikolin B,
|
||
Vuleta D,
|
||
Meriluoto J</span><br />
|
||
<span class="medgenPMjournal">J Environ Sci Health C Environ Carcinog Ecotoxicol Rev</span>
|
||
2014;32(4):319-37.
|
||
doi: 10.1080/10590501.2014.967053.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25436472" target="_blank">25436472</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2687904">The relationship between malignant melanoma of skin and exposure to sunlight.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee JA</span><br />
|
||
<span class="medgenPMjournal">Photochem Photobiol</span>
|
||
1989 Oct;50(4):493-6.
|
||
doi: 10.1111/j.1751-1097.1989.tb05554.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2687904" target="_blank">2687904</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2488447">Malignant melanoma of skin and eye in the same family: more than a coincidence?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Van Ruymbeke K,
|
||
Leys A</span><br />
|
||
<span class="medgenPMjournal">Bull Soc Belge Ophtalmol</span>
|
||
1989;231:149-55.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2488447" target="_blank">2488447</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malignant%20melanoma%20of%20skin%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (14)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39020276">Causal association between skin cancer and immune cells: mendelian randomization (MR) study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yin W,
|
||
Li R,
|
||
Zhang Z,
|
||
Wang Y,
|
||
Tang X,
|
||
Zhu L,
|
||
Yao H,
|
||
Li K</span><br />
|
||
<span class="medgenPMjournal">BMC Cancer</span>
|
||
2024 Jul 17;24(1):849.
|
||
doi: 10.1186/s12885-024-12603-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39020276" target="_blank">39020276</a><a href="/pmc/articles/PMC11256556" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34323875">Clinical Outcomes of Free, Public Skin Cancer Screening Events, Rhode Island, 2015-2019.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee KC,
|
||
Fulton JP,
|
||
Kazemi L,
|
||
George EA,
|
||
Smith CK,
|
||
Andoscia G,
|
||
Kawaoka JC,
|
||
Almeida-DoRosario A</span><br />
|
||
<span class="medgenPMjournal">R I Med J (2013)</span>
|
||
2021 Aug 2;104(6):22-27.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34323875" target="_blank">34323875</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29678984">Validating malignant melanoma ICD-9-CM codes in Umbria, ASL Napoli 3 Sud and Friuli Venezia Giulia administrative healthcare databases: a diagnostic accuracy study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Orso M,
|
||
Serraino D,
|
||
Abraha I,
|
||
Fusco M,
|
||
Giovannini G,
|
||
Casucci P,
|
||
Cozzolino F,
|
||
Granata A,
|
||
Gobbato M,
|
||
Stracci F,
|
||
Ciullo V,
|
||
Vitale MF,
|
||
Eusebi P,
|
||
Orlandi W,
|
||
Montedori A,
|
||
Bidoli E;
|
||
D.I.V.O. Group</span><br />
|
||
<span class="medgenPMjournal">BMJ Open</span>
|
||
2018 Apr 20;8(4):e020631.
|
||
doi: 10.1136/bmjopen-2017-020631.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29678984" target="_blank">29678984</a><a href="/pmc/articles/PMC5914898" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2687904">The relationship between malignant melanoma of skin and exposure to sunlight.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee JA</span><br />
|
||
<span class="medgenPMjournal">Photochem Photobiol</span>
|
||
1989 Oct;50(4):493-6.
|
||
doi: 10.1111/j.1751-1097.1989.tb05554.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2687904" target="_blank">2687904</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2488447">Malignant melanoma of skin and eye in the same family: more than a coincidence?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Van Ruymbeke K,
|
||
Leys A</span><br />
|
||
<span class="medgenPMjournal">Bull Soc Belge Ophtalmol</span>
|
||
1989;231:149-55.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2488447" target="_blank">2488447</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malignant%20melanoma%20of%20skin%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39020276">Causal association between skin cancer and immune cells: mendelian randomization (MR) study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yin W,
|
||
Li R,
|
||
Zhang Z,
|
||
Wang Y,
|
||
Tang X,
|
||
Zhu L,
|
||
Yao H,
|
||
Li K</span><br />
|
||
<span class="medgenPMjournal">BMC Cancer</span>
|
||
2024 Jul 17;24(1):849.
|
||
doi: 10.1186/s12885-024-12603-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39020276" target="_blank">39020276</a><a href="/pmc/articles/PMC11256556" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38787420">Causal relationship between genetically determined plasma metabolites and skin cancer: a two-sample Mendelian randomization study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shao X,
|
||
Yu R,
|
||
Zhao H,
|
||
Wu J,
|
||
Wu Q,
|
||
Shu P</span><br />
|
||
<span class="medgenPMjournal">Arch Dermatol Res</span>
|
||
2024 May 24;316(6):214.
|
||
doi: 10.1007/s00403-024-03011-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38787420" target="_blank">38787420</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38741062">Causal inference between pernicious anemia and cancers: a bidirectional two-sample mendelian randomization analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Che B,
|
||
Yuan S,
|
||
Zhang H,
|
||
Zhai J,
|
||
Zhang Y,
|
||
Wu C,
|
||
Tang K</span><br />
|
||
<span class="medgenPMjournal">BMC Cancer</span>
|
||
2024 May 13;24(1):586.
|
||
doi: 10.1186/s12885-024-12354-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38741062" target="_blank">38741062</a><a href="/pmc/articles/PMC11092143" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36896837">Occupational exposure register-based cohort study on mortality among asbestos-related workers in Italy after the ban.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Scarselli A,
|
||
Corfiati M,
|
||
Marinaccio A</span><br />
|
||
<span class="medgenPMjournal">Eur J Cancer Prev</span>
|
||
2023 May 1;32(3):281-285.
|
||
Epub 2023 Feb 27
|
||
doi: 10.1097/CEJ.0000000000000786.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36896837" target="_blank">36896837</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2687904">The relationship between malignant melanoma of skin and exposure to sunlight.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee JA</span><br />
|
||
<span class="medgenPMjournal">Photochem Photobiol</span>
|
||
1989 Oct;50(4):493-6.
|
||
doi: 10.1111/j.1751-1097.1989.tb05554.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2687904" target="_blank">2687904</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malignant%20melanoma%20of%20skin%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33989869">Greenspace exposure and cancer incidence: A 27-year follow-up of the French GAZEL cohort.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zare Sakhvidi MJ,
|
||
Yang J,
|
||
Siemiatycki J,
|
||
Dadvand P,
|
||
de Hoogh K,
|
||
Vienneau D,
|
||
Goldberg M,
|
||
Zins M,
|
||
Lequy E,
|
||
Jacquemin B</span><br />
|
||
<span class="medgenPMjournal">Sci Total Environ</span>
|
||
2021 Sep 15;787:147553.
|
||
Epub 2021 May 6
|
||
doi: 10.1016/j.scitotenv.2021.147553.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33989869" target="_blank">33989869</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25436472">Epidemiology of cancers in Serbia and possible connection with cyanobacterial blooms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Svirčev Z,
|
||
Drobac D,
|
||
Tokodi N,
|
||
Lužanin Z,
|
||
Munjas AM,
|
||
Nikolin B,
|
||
Vuleta D,
|
||
Meriluoto J</span><br />
|
||
<span class="medgenPMjournal">J Environ Sci Health C Environ Carcinog Ecotoxicol Rev</span>
|
||
2014;32(4):319-37.
|
||
doi: 10.1080/10590501.2014.967053.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25436472" target="_blank">25436472</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18822122">Variation in incidence of breast, lung and cervical cancer and malignant melanoma of skin by socioeconomic group in England.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shack L,
|
||
Jordan C,
|
||
Thomson CS,
|
||
Mak V,
|
||
Møller H;
|
||
UK Association of Cancer Registries</span><br />
|
||
<span class="medgenPMjournal">BMC Cancer</span>
|
||
2008 Sep 26;8:271.
|
||
doi: 10.1186/1471-2407-8-271.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18822122" target="_blank">18822122</a><a href="/pmc/articles/PMC2577116" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1501812">Primary malignant melanoma of skin in four regions of New Zealand.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cooke K,
|
||
McNoe B,
|
||
Hursthouse M,
|
||
Taylor R</span><br />
|
||
<span class="medgenPMjournal">N Z Med J</span>
|
||
1992 Aug 12;105(939):303-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1501812" target="_blank">1501812</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2687904">The relationship between malignant melanoma of skin and exposure to sunlight.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee JA</span><br />
|
||
<span class="medgenPMjournal">Photochem Photobiol</span>
|
||
1989 Oct;50(4):493-6.
|
||
doi: 10.1111/j.1751-1097.1989.tb05554.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2687904" target="_blank">2687904</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malignant%20melanoma%20of%20skin%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38787420">Causal relationship between genetically determined plasma metabolites and skin cancer: a two-sample Mendelian randomization study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shao X,
|
||
Yu R,
|
||
Zhao H,
|
||
Wu J,
|
||
Wu Q,
|
||
Shu P</span><br />
|
||
<span class="medgenPMjournal">Arch Dermatol Res</span>
|
||
2024 May 24;316(6):214.
|
||
doi: 10.1007/s00403-024-03011-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38787420" target="_blank">38787420</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38741062">Causal inference between pernicious anemia and cancers: a bidirectional two-sample mendelian randomization analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Che B,
|
||
Yuan S,
|
||
Zhang H,
|
||
Zhai J,
|
||
Zhang Y,
|
||
Wu C,
|
||
Tang K</span><br />
|
||
<span class="medgenPMjournal">BMC Cancer</span>
|
||
2024 May 13;24(1):586.
|
||
doi: 10.1186/s12885-024-12354-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38741062" target="_blank">38741062</a><a href="/pmc/articles/PMC11092143" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33989869">Greenspace exposure and cancer incidence: A 27-year follow-up of the French GAZEL cohort.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zare Sakhvidi MJ,
|
||
Yang J,
|
||
Siemiatycki J,
|
||
Dadvand P,
|
||
de Hoogh K,
|
||
Vienneau D,
|
||
Goldberg M,
|
||
Zins M,
|
||
Lequy E,
|
||
Jacquemin B</span><br />
|
||
<span class="medgenPMjournal">Sci Total Environ</span>
|
||
2021 Sep 15;787:147553.
|
||
Epub 2021 May 6
|
||
doi: 10.1016/j.scitotenv.2021.147553.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33989869" target="_blank">33989869</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25436472">Epidemiology of cancers in Serbia and possible connection with cyanobacterial blooms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Svirčev Z,
|
||
Drobac D,
|
||
Tokodi N,
|
||
Lužanin Z,
|
||
Munjas AM,
|
||
Nikolin B,
|
||
Vuleta D,
|
||
Meriluoto J</span><br />
|
||
<span class="medgenPMjournal">J Environ Sci Health C Environ Carcinog Ecotoxicol Rev</span>
|
||
2014;32(4):319-37.
|
||
doi: 10.1080/10590501.2014.967053.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25436472" target="_blank">25436472</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18822122">Variation in incidence of breast, lung and cervical cancer and malignant melanoma of skin by socioeconomic group in England.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shack L,
|
||
Jordan C,
|
||
Thomson CS,
|
||
Mak V,
|
||
Møller H;
|
||
UK Association of Cancer Registries</span><br />
|
||
<span class="medgenPMjournal">BMC Cancer</span>
|
||
2008 Sep 26;8:271.
|
||
doi: 10.1186/1471-2407-8-271.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18822122" target="_blank">18822122</a><a href="/pmc/articles/PMC2577116" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malignant%20melanoma%20of%20skin%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
||
<div class="portlet mgSection" id="ID_113">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_106">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0151779%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (9)</a></li>
|
||
<li><a href="/gtr/tests?term=C0151779%5bDISCUI%5d&filter=method%3A3%5F23" target="_blank">FISH-interphase (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0151779%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0151779%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (12)</a></li>
|
||
<li><a href="/gtr/tests?term=C0151779%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (1)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0151779%5bDISCUI%5d" target="_blank">See all (16)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_119">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Malignant%20melanoma%20of%20skin" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22malignant%20melanoma%20of%20skin%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Malignant%20melanoma%20of%20skin%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/cutaneous_melanoma.pdf">NCCN, 2024</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Melanoma: Cutaneous, 2024</div></li><li><a target="_blank" href="https://www.nice.org.uk/guidance/ng14">NICE, 2022</a><div>UK NICE Guideline NG14, Melanoma: assessment and management, 2022</div></li><li><a target="_blank" href="http://www.nice.org.uk/guidance/ta269/chapter/guidance">NICE, 2015</a><div>Vemurafenib for treating locally advanced or metastatic BRAF V600 mutation-positive malignant melanoma (Updated 1 January 2015)</div></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_116">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Malignant+melanoma+of+skin/8784" target="_blank">Genetic Alliance</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Malignant%20melanoma%20of%20skin" target="_blank">MedlinePlus</a></li><li><a href="https://medlineplus.gov/genetics/condition/melanoma" target="_blank">MedlinePlusGenetics (GHR)</a></li></ul></div>
|
||
</div>
|
||
</div>
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Reviews</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Reviews" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pubmed/clinical?term=Malignant%20melanoma%20of%20skin" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed?term=Malignant%20melanoma%20of%20skin%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<!-- MedGen supplemental column ends here -->
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=57486" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0151779[DISCUI]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0151779[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim&from_uid=57486" ref="log$=recordlinks">OMIM</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related records in OMIM</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=57486" ref="log$=recordlinks">PMC Articles</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in PubMed Central Links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&from_uid=57486" ref="log$=recordlinks">PubMed</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_omim&from_uid=57486" ref="log$=recordlinks">PubMed (OMIM)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Recent activity</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter"></a>
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||
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|
||
<div class="portlet_content">
|
||
<div id="HTDisplay" class="">
|
||
<input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Cmd" sid="1" type="hidden" />
|
||
<div class="action">
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory">
|
||
Clear
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn Off
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" sid="2" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOff" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn On
|
||
</a>
|
||
</div>
|
||
<ul id="activity">
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67cfd8d2a68b6b5afc56ad49">Malignant melanoma of skin</a>
|
||
<div class="ralinkpop offscreen_noflow">Malignant melanoma of skin<div class="brieflinkpopdesc"></div></div>
|
||
<div class="tertiary">MedGen</div>
|
||
</li>
|
||
<li class="ra_qry two_line">
|
||
<a class="htb" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67cfd8d0f4a390645e25ba19">C0151779[conceptid] <span class="number">(1)</span></a>
|
||
<div class="tertiary">MedGen</div>
|
||
</li>
|
||
<li class="ra_qry ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67cfd8cfa68b6b5afc5696b0">C0684249[trait identifier] AND "ClinVar Staff, National Center fo... <span class="number">(5)</span></a>
|
||
<div class="ralinkpop offscreen_noflow">C0684249[trait identifier] AND "ClinVar Staff, National Center for Biotechnology Information (NCBI)"[submitter]<div class="brieflinkpopdesc">Search</div></div>
|
||
<div class="tertiary">ClinVar</div>
|
||
</li>
|
||
<li class="ra_qry ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67cfd8ceb15b832ebcfefd44">C4551647[trait identifier] AND "ClinVar Staff, National Center fo... <span class="number">(26)</span></a>
|
||
<div class="ralinkpop offscreen_noflow">C4551647[trait identifier] AND "ClinVar Staff, National Center for Biotechnology Information (NCBI)"[submitter]<div class="brieflinkpopdesc">Search</div></div>
|
||
<div class="tertiary">ClinVar</div>
|
||
</li>
|
||
<li class="ra_qry ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67cfd8cca68b6b5afc56870a">C0339527[trait identifier] AND "ClinVar Staff, National Center fo... <span class="number">(1)</span></a>
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