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<meta name="keywords" content="C0040479, de pointes, torsade, de pointes, torsades, disease or syndrome, pointes, torsade de, pointes, torsades de, torsade de pointes, torsades de pointes, torsades de pointes by ecg finding, torsades de pointes by ekg finding, twisting spikes, ventricular tachycardia, polymorphic with q-t prolongation, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A type of ventricular tachycardia characterized by polymorphioc QRS complexes that change in amplitue and cycle length, and thus have the appearance of oscillating around the baseline in the EKG." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=21214
|
||
ConceptID=C0040479
|
||
-->
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||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Torsade de pointes</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>21214</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0040479</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Torsades de pointes</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Ventricular tachycardia, polymorphic with Q-T prolongation (31722008); Torsade de pointes (31722008); Torsades de pointes (31722008); Twisting spikes (31722008)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0001664">HP:0001664</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0005478" target="_blank">MONDO:0005478</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">A type of ventricular tachycardia characterized by polymorphioc QRS complexes that change in amplitue and cycle length, and thus have the appearance of oscillating around the baseline in the EKG. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Torsade de pointes</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/576279" ref="tree=MeSH" title="MedGen record for EKG: ventricular tachycardia">EKG: ventricular tachycardia</a></span><ul><li><span class="matched_ds">Torsade de pointes</span></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_320273"><div><strong>Sick sinus syndrome 2, autosomal dominant</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>320273</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1834144</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Sick sinus syndrome (also known as sinus node dysfunction) is a group of related heart conditions that can affect how the heart beats. "Sick sinus" refers to the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The SA node generates electrical impulses that start each heartbeat. These signals travel from the SA node to the rest of the heart, signaling the heart (cardiac) muscle to contract and pump blood. In people with sick sinus syndrome, the SA node does not function normally. In some cases, it does not produce the right signals to trigger a regular heartbeat. In others, abnormalities disrupt the electrical impulses and prevent them from reaching the rest of the heart.\n\nSick sinus syndrome tends to cause the heartbeat to be too slow (bradycardia), although occasionally the heartbeat is too fast (tachycardia). In some cases, the heartbeat rapidly switches from being too fast to being too slow, a condition known as tachycardia-bradycardia syndrome. Symptoms related to abnormal heartbeats can include dizziness, light-headedness, fainting (syncope), a sensation of fluttering or pounding in the chest (palpitations), and confusion or memory problems. During exercise, many affected individuals experience chest pain, difficulty breathing, or excessive tiredness (fatigue). Once symptoms of sick sinus syndrome appear, they usually worsen with time. However, some people with the condition never experience any related health problems.\n\nSick sinus syndrome occurs most commonly in older adults, although it can be diagnosed in people of any age. The condition increases the risk of several life-threatening problems involving the heart and blood vessels. These include a heart rhythm abnormality called atrial fibrillation, heart failure, cardiac arrest, and stroke.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/320273">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_349087"><div><strong>Long QT syndrome 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>349087</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1859062</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999). For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 (192500).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/349087">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_358092"><div><strong>Long QT syndrome 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>358092</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1867904</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999). For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 (192500).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/358092">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_394108"><div><strong>Jervell and Lange-Nielsen syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>394108</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2676723</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Jervell and Lange-Nielsen syndrome (JLNS) is characterized by congenital profound bilateral sensorineural hearing loss and long QTc, usually >500 msec. Prolongation of the QTc interval is associated with tachyarrhythmias, including ventricular tachycardia, episodes of torsade de pointes ventricular tachycardia, and ventricular fibrillation, which may culminate in syncope or sudden death. Iron-deficient anemia and elevated levels of gastrin are also frequent features of JLNS. The classic presentation of JLNS is a deaf child who experiences syncopal episodes during periods of stress, exercise, or fright. Fifty percent of individuals with JLNS had cardiac events before age three years. More than half of untreated children with JLNS die before age 15 years.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/394108">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_442824"><div><strong>Long QT syndrome 12</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>442824</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2751830</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital long QT syndrome (LQTS) is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999). For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 (192500).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/442824">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462083"><div><strong>Long QT syndrome 13</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462083</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3150733</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999). For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 (192500).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462083">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462293"><div><strong>Long QT syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462293</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3150943</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999). For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 (192500).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462293">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462303"><div><strong>Long QT syndrome 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462303</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3150953</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999). For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 (192500).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462303">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_477078"><div><strong>Ogden syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>477078</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3275447</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Ogden syndrome (OGDNS) is an X-linked neurodevelopmental disorder characterized by postnatal growth failure, severely delayed psychomotor development, variable dysmorphic features, and hypotonia. Many patients also have cardiac malformations or arrhythmias (summary by Popp et al., 2015).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/477078">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1646925"><div><strong>Jervell and Lange-Nielsen syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1646925</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551509</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Jervell and Lange-Nielsen syndrome (JLNS) is characterized by congenital profound bilateral sensorineural hearing loss and long QTc, usually >500 msec. Prolongation of the QTc interval is associated with tachyarrhythmias, including ventricular tachycardia, episodes of torsade de pointes ventricular tachycardia, and ventricular fibrillation, which may culminate in syncope or sudden death. Iron-deficient anemia and elevated levels of gastrin are also frequent features of JLNS. The classic presentation of JLNS is a deaf child who experiences syncopal episodes during periods of stress, exercise, or fright. Fifty percent of individuals with JLNS had cardiac events before age three years. More than half of untreated children with JLNS die before age 15 years.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1646925">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1641146"><div><strong>Long QT syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1641146</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551647</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An autosomal dominant condition caused by mutation(s) in the KCNQ1 gene, encoding potassium voltage-gated channel subfamily KQT member 1. It is characterized by a prolonged QT interval that may result in torsade de pointes, ventricular fibrillation and/or sudden cardiac death.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1641146">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1781114"><div><strong>Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1781114</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5542154</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome (VACRDS) is characterized by syncope, cardiac arrest, and/or sudden unexpected death. Polymorphic ventricular tachycardia and ventricular fibrillation have been documented in these patients. Symptoms generally occur with physical activity or emotional stress, but unlike typical catecholaminergic ventricular tachycardia (CPVT), arrhythmias are not reproducible on exercise stress testing or adrenaline challenge (Sun et al., 2021). Mutation in the RYR2 gene also causes catecholaminergic polymorphic ventricular tachycardia-1 (CPVT1; 604772).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1781114">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1798947"><div><strong>Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1798947</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5567524</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">TANGO2 deficiency is characterized by developmental delay, intellectual disability, gait incoordination, speech difficulties, seizures, and hypothyroidism. Most individuals have TANGO2 spells, non-life-threatening paroxysmal worsening of baseline symptoms, including sudden onset of hypotonia, ataxia with loss of balance, head and body tilt, increased dysarthria, drooling, lethargy, and disorientation. In addition, life-threatening acute metabolic crises can occur, including rhabdomyolysis with elevated creatine phosphokinase and liver transaminases, hypoglycemia, prolonged QTc on EKG, ventricular arrhythmias, and/or cardiomyopathy.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1798947">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1646925" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Jervell and Lange-Nielsen syndrome 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_394108" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Jervell and Lange-Nielsen syndrome 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1641146" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_442824" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 12</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462083" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 13</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (13)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462293" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_349087" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_358092" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 5</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462303" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Long QT syndrome 6</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_477078" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ogden syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1798947" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_320273" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Sick sinus syndrome 2, autosomal dominant</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1781114" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32888379">Risk Assessment of Drug-Induced Long QT Syndrome for Some COVID-19 Repurposed Drugs.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Michaud V,
|
||
Dow P,
|
||
Al Rihani SB,
|
||
Deodhar M,
|
||
Arwood M,
|
||
Cicali B,
|
||
Turgeon J</span><br />
|
||
<span class="medgenPMjournal">Clin Transl Sci</span>
|
||
2021 Jan;14(1):20-28.
|
||
Epub 2020 Nov 18
|
||
doi: 10.1111/cts.12882.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32888379" target="_blank">32888379</a><a href="/pmc/articles/PMC7877829" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20142454">Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Drew BJ,
|
||
Ackerman MJ,
|
||
Funk M,
|
||
Gibler WB,
|
||
Kligfield P,
|
||
Menon V,
|
||
Philippides GJ,
|
||
Roden DM,
|
||
Zareba W;
|
||
American Heart Association Acute Cardiac Care Committee of the Council on Clinical Cardiology, the Council on Cardiovascular Nursing, and the American College of Cardiology Foundation</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
2010 Mar 2;121(8):1047-60.
|
||
Epub 2010 Feb 8
|
||
doi: 10.1161/CIRCULATIONAHA.109.192704.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20142454" target="_blank">20142454</a><a href="/pmc/articles/PMC3056123" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7355767">Treatment of torsade de pointes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Parizel G,
|
||
Ranquin R</span><br />
|
||
<span class="medgenPMjournal">Am J Cardiol</span>
|
||
1980 Mar;45(3):716.
|
||
doi: 10.1016/s0002-9149(80)80029-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7355767" target="_blank">7355767</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22torsade%20de%20pointes%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (108)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/29473523">Drug-induced QT Interval Prolongation in the Intensive Care Unit.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Etchegoyen CV,
|
||
Keller GA,
|
||
Mrad S,
|
||
Cheng S,
|
||
Di Girolamo G</span><br />
|
||
<span class="medgenPMjournal">Curr Clin Pharmacol</span>
|
||
2017;12(4):210-222.
|
||
doi: 10.2174/1574884713666180223123947.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29473523" target="_blank">29473523</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28012118">Risk factors for QTc-prolongation: systematic review of the evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vandael E,
|
||
Vandenberk B,
|
||
Vandenberghe J,
|
||
Willems R,
|
||
Foulon V</span><br />
|
||
<span class="medgenPMjournal">Int J Clin Pharm</span>
|
||
2017 Feb;39(1):16-25.
|
||
Epub 2016 Dec 23
|
||
doi: 10.1007/s11096-016-0414-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28012118" target="_blank">28012118</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22474311">Clinical and genetic determinants of torsade de pointes risk.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sauer AJ,
|
||
Newton-Cheh C</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
2012 Apr 3;125(13):1684-94.
|
||
doi: 10.1161/CIRCULATIONAHA.111.080887.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22474311" target="_blank">22474311</a><a href="/pmc/articles/PMC3347483" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11233957">Proarrhythmia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Naccarelli GV,
|
||
Wolbrette DL,
|
||
Luck JC</span><br />
|
||
<span class="medgenPMjournal">Med Clin North Am</span>
|
||
2001 Mar;85(2):503-26, xii.
|
||
doi: 10.1016/s0025-7125(05)70324-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11233957" target="_blank">11233957</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9717023">Atrial flutter.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Campbell RW</span><br />
|
||
<span class="medgenPMjournal">Eur Heart J</span>
|
||
1998 May;19 Suppl E:E37-40, E60-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9717023" target="_blank">9717023</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Torsade%20de%20pointes%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (769)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34491774">Polymorphic Ventricular Tachycardia: Terminology, Mechanism, Diagnosis, and Emergency Therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Viskin S,
|
||
Chorin E,
|
||
Viskin D,
|
||
Hochstadt A,
|
||
Schwartz AL,
|
||
Rosso R</span><br />
|
||
<span class="medgenPMjournal">Circulation</span>
|
||
2021 Sep 7;144(10):823-839.
|
||
doi: 10.1161/CIRCULATIONAHA.121.055783.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34491774" target="_blank">34491774</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28012118">Risk factors for QTc-prolongation: systematic review of the evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vandael E,
|
||
Vandenberk B,
|
||
Vandenberghe J,
|
||
Willems R,
|
||
Foulon V</span><br />
|
||
<span class="medgenPMjournal">Int J Clin Pharm</span>
|
||
2017 Feb;39(1):16-25.
|
||
Epub 2016 Dec 23
|
||
doi: 10.1007/s11096-016-0414-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28012118" target="_blank">28012118</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21660912">Electrolyte disorders and arrhythmogenesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">El-Sherif N,
|
||
Turitto G</span><br />
|
||
<span class="medgenPMjournal">Cardiol J</span>
|
||
2011;18(3):233-45.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21660912" target="_blank">21660912</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11233957">Proarrhythmia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Naccarelli GV,
|
||
Wolbrette DL,
|
||
Luck JC</span><br />
|
||
<span class="medgenPMjournal">Med Clin North Am</span>
|
||
2001 Mar;85(2):503-26, xii.
|
||
doi: 10.1016/s0025-7125(05)70324-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11233957" target="_blank">11233957</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9717023">Atrial flutter.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Campbell RW</span><br />
|
||
<span class="medgenPMjournal">Eur Heart J</span>
|
||
1998 May;19 Suppl E:E37-40, E60-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9717023" target="_blank">9717023</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Torsade%20de%20pointes%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (493)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33446314">Cardiovascular Complications of Opioid Use: JACC State-of-the-Art Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Krantz MJ,
|
||
Palmer RB,
|
||
Haigney MCP</span><br />
|
||
<span class="medgenPMjournal">J Am Coll Cardiol</span>
|
||
2021 Jan 19;77(2):205-223.
|
||
doi: 10.1016/j.jacc.2020.11.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33446314" target="_blank">33446314</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28012118">Risk factors for QTc-prolongation: systematic review of the evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vandael E,
|
||
Vandenberk B,
|
||
Vandenberghe J,
|
||
Willems R,
|
||
Foulon V</span><br />
|
||
<span class="medgenPMjournal">Int J Clin Pharm</span>
|
||
2017 Feb;39(1):16-25.
|
||
Epub 2016 Dec 23
|
||
doi: 10.1007/s11096-016-0414-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28012118" target="_blank">28012118</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11233957">Proarrhythmia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Naccarelli GV,
|
||
Wolbrette DL,
|
||
Luck JC</span><br />
|
||
<span class="medgenPMjournal">Med Clin North Am</span>
|
||
2001 Mar;85(2):503-26, xii.
|
||
doi: 10.1016/s0025-7125(05)70324-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11233957" target="_blank">11233957</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9717023">Atrial flutter.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Campbell RW</span><br />
|
||
<span class="medgenPMjournal">Eur Heart J</span>
|
||
1998 May;19 Suppl E:E37-40, E60-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9717023" target="_blank">9717023</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2672929">Amiodarone and torsade de pointes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lazzara R</span><br />
|
||
<span class="medgenPMjournal">Ann Intern Med</span>
|
||
1989 Oct 1;111(7):549-51.
|
||
doi: 10.7326/0003-4819-111-7-549.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2672929" target="_blank">2672929</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Torsade%20de%20pointes%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (907)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33554620">Worldwide Survey of COVID-19-Associated Arrhythmias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Coromilas EJ,
|
||
Kochav S,
|
||
Goldenthal I,
|
||
Biviano A,
|
||
Garan H,
|
||
Goldbarg S,
|
||
Kim JH,
|
||
Yeo I,
|
||
Tracy C,
|
||
Ayanian S,
|
||
Akar J,
|
||
Singh A,
|
||
Jain S,
|
||
Zimerman L,
|
||
Pimentel M,
|
||
Osswald S,
|
||
Twerenbold R,
|
||
Schaerli N,
|
||
Crotti L,
|
||
Fabbri D,
|
||
Parati G,
|
||
Li Y,
|
||
Atienza F,
|
||
Zatarain E,
|
||
Tse G,
|
||
Leung KSK,
|
||
Guevara-Valdivia ME,
|
||
Rivera-Santiago CA,
|
||
Soejima K,
|
||
De Filippo P,
|
||
Ferrari P,
|
||
Malanchini G,
|
||
Kanagaratnam P,
|
||
Khawaja S,
|
||
Mikhail GW,
|
||
Scanavacca M,
|
||
Abrahão Hajjar L,
|
||
Rizerio B,
|
||
Sacilotto L,
|
||
Mollazadeh R,
|
||
Eslami M,
|
||
Laleh Far V,
|
||
Mattioli AV,
|
||
Boriani G,
|
||
Migliore F,
|
||
Cipriani A,
|
||
Donato F,
|
||
Compagnucci P,
|
||
Casella M,
|
||
Dello Russo A,
|
||
Coromilas J,
|
||
Aboyme A,
|
||
O'Brien CG,
|
||
Rodriguez F,
|
||
Wang PJ,
|
||
Naniwadekar A,
|
||
Moey M,
|
||
Kow CS,
|
||
Cheah WK,
|
||
Auricchio A,
|
||
Conte G,
|
||
Hwang J,
|
||
Han S,
|
||
Lazzerini PE,
|
||
Franchi F,
|
||
Santoro A,
|
||
Capecchi PL,
|
||
Joglar JA,
|
||
Rosenblatt AG,
|
||
Zardini M,
|
||
Bricoli S,
|
||
Bonura R,
|
||
Echarte-Morales J,
|
||
Benito-González T,
|
||
Minguito-Carazo C,
|
||
Fernández-Vázquez F,
|
||
Wan EY</span><br />
|
||
<span class="medgenPMjournal">Circ Arrhythm Electrophysiol</span>
|
||
2021 Mar;14(3):e009458.
|
||
Epub 2021 Feb 7
|
||
doi: 10.1161/CIRCEP.120.009458.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33554620" target="_blank">33554620</a><a href="/pmc/articles/PMC7982128" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32947483">Andersen-Tawil Syndrome: A Comprehensive Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pérez-Riera AR,
|
||
Barbosa-Barros R,
|
||
Samesina N,
|
||
Pastore CA,
|
||
Scanavacca M,
|
||
Daminello-Raimundo R,
|
||
de Abreu LC,
|
||
Nikus K,
|
||
Brugada P</span><br />
|
||
<span class="medgenPMjournal">Cardiol Rev</span>
|
||
2021 Jul-Aug 01;29(4):165-177.
|
||
doi: 10.1097/CRD.0000000000000326.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32947483" target="_blank">32947483</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26560188">A 2015 focus on preventing drug-induced arrhythmias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bossu A,
|
||
van der Heyden MA,
|
||
de Boer TP,
|
||
Vos MA</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Cardiovasc Ther</span>
|
||
2016;14(2):245-53.
|
||
Epub 2015 Nov 26
|
||
doi: 10.1586/14779072.2016.1116940.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26560188" target="_blank">26560188</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11233957">Proarrhythmia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Naccarelli GV,
|
||
Wolbrette DL,
|
||
Luck JC</span><br />
|
||
<span class="medgenPMjournal">Med Clin North Am</span>
|
||
2001 Mar;85(2):503-26, xii.
|
||
doi: 10.1016/s0025-7125(05)70324-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11233957" target="_blank">11233957</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9717023">Atrial flutter.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Campbell RW</span><br />
|
||
<span class="medgenPMjournal">Eur Heart J</span>
|
||
1998 May;19 Suppl E:E37-40, E60-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9717023" target="_blank">9717023</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Torsade%20de%20pointes%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (347)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34448003">Effect of dapagliflozin on ventricular arrhythmias, resuscitated cardiac arrest, or sudden death in DAPA-HF.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Curtain JP,
|
||
Docherty KF,
|
||
Jhund PS,
|
||
Petrie MC,
|
||
Inzucchi SE,
|
||
Køber L,
|
||
Kosiborod MN,
|
||
Martinez FA,
|
||
Ponikowski P,
|
||
Sabatine MS,
|
||
Bengtsson O,
|
||
Langkilde AM,
|
||
Sjöstrand M,
|
||
Solomon SD,
|
||
McMurray JJV</span><br />
|
||
<span class="medgenPMjournal">Eur Heart J</span>
|
||
2021 Sep 21;42(36):3727-3738.
|
||
doi: 10.1093/eurheartj/ehab560.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34448003" target="_blank">34448003</a><a href="/pmc/articles/PMC8455345" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32947483">Andersen-Tawil Syndrome: A Comprehensive Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pérez-Riera AR,
|
||
Barbosa-Barros R,
|
||
Samesina N,
|
||
Pastore CA,
|
||
Scanavacca M,
|
||
Daminello-Raimundo R,
|
||
de Abreu LC,
|
||
Nikus K,
|
||
Brugada P</span><br />
|
||
<span class="medgenPMjournal">Cardiol Rev</span>
|
||
2021 Jul-Aug 01;29(4):165-177.
|
||
doi: 10.1097/CRD.0000000000000326.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32947483" target="_blank">32947483</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28012118">Risk factors for QTc-prolongation: systematic review of the evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vandael E,
|
||
Vandenberk B,
|
||
Vandenberghe J,
|
||
Willems R,
|
||
Foulon V</span><br />
|
||
<span class="medgenPMjournal">Int J Clin Pharm</span>
|
||
2017 Feb;39(1):16-25.
|
||
Epub 2016 Dec 23
|
||
doi: 10.1007/s11096-016-0414-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28012118" target="_blank">28012118</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26560188">A 2015 focus on preventing drug-induced arrhythmias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bossu A,
|
||
van der Heyden MA,
|
||
de Boer TP,
|
||
Vos MA</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Cardiovasc Ther</span>
|
||
2016;14(2):245-53.
|
||
Epub 2015 Nov 26
|
||
doi: 10.1586/14779072.2016.1116940.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26560188" target="_blank">26560188</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12496496">Torsade de pointes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">El-Sherif N,
|
||
Turitto G</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Cardiol</span>
|
||
2003 Jan;18(1):6-13.
|
||
doi: 10.1097/00001573-200301000-00002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12496496" target="_blank">12496496</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Torsade%20de%20pointes%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (426)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/33342426">A systematic review assessing the under-representation of elderly adults in COVID-19 trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Prendki V,
|
||
Tau N,
|
||
Avni T,
|
||
Falcone M,
|
||
Huttner A,
|
||
Kaiser L,
|
||
Paul M,
|
||
Leibovici-Weissmann Y,
|
||
Yahav D;
|
||
ESCMID Study Group for Infections in the Elderly (ESGIE)</span><br />
|
||
<span class="medgenPMjournal">BMC Geriatr</span>
|
||
2020 Dec 20;20(1):538.
|
||
doi: 10.1186/s12877-020-01954-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33342426" target="_blank">33342426</a><a href="/pmc/articles/PMC7749979" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28012118">Risk factors for QTc-prolongation: systematic review of the evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vandael E,
|
||
Vandenberk B,
|
||
Vandenberghe J,
|
||
Willems R,
|
||
Foulon V</span><br />
|
||
<span class="medgenPMjournal">Int J Clin Pharm</span>
|
||
2017 Feb;39(1):16-25.
|
||
Epub 2016 Dec 23
|
||
doi: 10.1007/s11096-016-0414-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28012118" target="_blank">28012118</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23787716">QTc interval screening for cardiac risk in methadone treatment of opioid dependence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pani PP,
|
||
Trogu E,
|
||
Maremmani I,
|
||
Pacini M</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2013 Jun 20;(6):CD008939.
|
||
doi: 10.1002/14651858.CD008939.pub2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23787716" target="_blank">23787716</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23744954">Perioperative torsade de pointes: a systematic review of published case reports.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Johnston J,
|
||
Pal S,
|
||
Nagele P</span><br />
|
||
<span class="medgenPMjournal">Anesth Analg</span>
|
||
2013 Sep;117(3):559-564.
|
||
Epub 2013 Jun 6
|
||
doi: 10.1213/ANE.0b013e318290c380.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23744954" target="_blank">23744954</a><a href="/pmc/articles/PMC3750104" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12101132">The role of magnesium in the emergency department.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kaye P,
|
||
O'Sullivan I</span><br />
|
||
<span class="medgenPMjournal">Emerg Med J</span>
|
||
2002 Jul;19(4):288-91.
|
||
doi: 10.1136/emj.19.4.288.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12101132" target="_blank">12101132</a><a href="/pmc/articles/PMC1725934" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Torsade%20de%20pointes%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (20)</a></div></div>
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