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<meta name="keywords" content="C0026707, atypical chondrodystrophy, brailsford-morquio syndrome, chondro-osteodystrophy, chondrodystrophia tarda, deficiency of chondroitinsulphatase, disease or syndrome, disease, morquio, disease, morquio's, eccentro osteochondrodysplasia, eccentro-osteochondrodysplasia, eccentro-osteochondrodysplasias, eccentrochondrodysplasia, eccentroosteochondrodysplasia, eccentroosteochondrodysplasias, familial osseous dystrophy, familial osteochondrodystrophy, hereditary enchondral dysostosis, iv, mucopolysaccharidosis type, ivs, mucopolysaccharidosis type, keratan sulfaturia, morquio disease, morquio syndrome, morquio syndromes, morquio's disease, morquio's syndrome, morquio-brailsford disease, morquio-suarez syndrome, morquio-ullrich disease, morquios disease, morquios syndrome, mps iv, mps4, mpsiv, mucopolysaccharidosis 4, mucopolysaccharidosis iv, mucopolysaccharidosis type 4, mucopolysaccharidosis type iv, mucopolysaccharidosis type ivs, mucopolysaccharidosis, mps-iv, mucopolysaccharidosis, type iv, osteochondrodystrophia deformans, osteochondrodystrophy, syndrome, morquio, syndrome, morquio's, syndromes, morquio, type iv, mucopolysaccharidosis, type ivs, mucopolysaccharidosis, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="The life expectancy of individuals with MPS IV depends on the severity of symptoms. Severely affected individuals may survive only until late childhood or adolescence. Those with milder forms of the disorder usually live into adulthood, although their life expectancy may be reduced. Spinal cord compression and airway obstruction are major causes of death in people with MPS IV.\n\nMucopolysaccharidosis type IV (MPS IV), also known as Morquio syndrome, is a progressive condition that mainly affects the skeleton. The rate at which symptoms worsen varies among affected individuals.\n\nThe first signs and symptoms of MPS IV usually become apparent during early childhood. Affected individuals develop various skeletal abnormalities, including short stature, knock knees, and abnormalities of the ribs, chest, spine, hips, and wrists. People with MPS IV often have joints that are loose and very flexible (hypermobile), but they may also have restricted movement in certain joints. A characteristic feature of this condition is underdevelopment (hypoplasia) of a peg-like bone in the neck called the odontoid process. The odontoid process helps stabilize the spinal bones in the neck (cervical vertebrae). Odontoid hypoplasia can lead to misalignment of the cervical vertebrae, which may compress and damage the spinal cord, resulting in paralysis or death.\n\nIn people with MPS IV, the clear covering of the eye (cornea) typically becomes cloudy, which can cause vision loss. Some affected individuals have recurrent ear infections and hearing loss. The airway may become narrow in some people with MPS IV, leading to frequent upper respiratory infections and short pauses in breathing during sleep (sleep apnea). Other common features of this condition include mildly "coarse" facial features, thin tooth enamel, multiple cavities, heart valve abnormalities, a mildly enlarged liver (hepatomegaly), and a soft out-pouching around the belly-button (umbilical hernia) or lower abdomen (inguinal hernia). Unlike some other types of mucopolysaccharidosis, MPS IV does not affect intelligence." /><meta name="robots" content="index,nofollow,noarchive" />
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<div><div class="rprt full-rprt"><div class="portlet" style="border-top-style: none; margin-top: 0px; padding-top: 0px; margin-bottom: 0px; padding-left: 0.2em;">
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<!--
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UID=44513
|
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ConceptID=C0026707
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Morquio syndrome</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>44513</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0026707</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Eccentrochondrodysplasia; MPS IV; Mucopolysaccharidosis type 4; Mucopolysaccharidosis, Type IV</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Morquio syndrome (378007); Chondro-osteodystrophy (378007); Morquio-Suarez syndrome (378007); Morquio-Ullrich disease (378007); Osteochondrodystrophia deformans (378007); Atypical chondrodystrophy (378007); Morquio disease (378007); Familial osteochondrodystrophy (378007); Brailsford-Morquio syndrome (378007); Hereditary enchondral dysostosis (378007); Chondrodystrophia tarda (378007); Familial osseous dystrophy (378007); Keratan sulfaturia (378007); Mucopolysaccharidosis, MPS-IV (378007); Morquio-Brailsford disease (378007); Osteochondrodystrophy (378007); Mucopolysaccharidosis type IV (378007)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_141025"><div><strong>Autosomal recessive inheritance</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>141025</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0441748</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Intellectual Product</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygotes (two copies of the same mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).</div></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_141025" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal recessive inheritance</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help" data-jig="ncbipopper" href="#target-gene-related">Related genes:<img src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div id="target-gene-related" class="display-none">
|
||
Gene(s) associated with related conditions. For conditions<br />
|
||
in a hierarchy, the parent condition will list the genes<br />
|
||
associated with the children conditions.</div></td>
|
||
<td><a target="_blank" href="/gene/2720">GLB1</a>, <a target="_blank" href="/gene/2588">GALNS</a></td></tr><tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0018938" target="_blank">MONDO:0018938</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=582">ORPHA582</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">The life expectancy of individuals with MPS IV depends on the severity of symptoms. Severely affected individuals may survive only until late childhood or adolescence. Those with milder forms of the disorder usually live into adulthood, although their life expectancy may be reduced. Spinal cord compression and airway obstruction are major causes of death in people with MPS IV.<br /><br />Mucopolysaccharidosis type IV (MPS IV), also known as Morquio syndrome, is a progressive condition that mainly affects the skeleton. The rate at which symptoms worsen varies among affected individuals.<br /><br />The first signs and symptoms of MPS IV usually become apparent during early childhood. Affected individuals develop various skeletal abnormalities, including short stature, knock knees, and abnormalities of the ribs, chest, spine, hips, and wrists. People with MPS IV often have joints that are loose and very flexible (hypermobile), but they may also have restricted movement in certain joints. A characteristic feature of this condition is underdevelopment (hypoplasia) of a peg-like bone in the neck called the odontoid process. The odontoid process helps stabilize the spinal bones in the neck (cervical vertebrae). Odontoid hypoplasia can lead to misalignment of the cervical vertebrae, which may compress and damage the spinal cord, resulting in paralysis or death.<br /><br />In people with MPS IV, the clear covering of the eye (cornea) typically becomes cloudy, which can cause vision loss. Some affected individuals have recurrent ear infections and hearing loss. The airway may become narrow in some people with MPS IV, leading to frequent upper respiratory infections and short pauses in breathing during sleep (sleep apnea). Other common features of this condition include mildly "coarse" facial features, thin tooth enamel, multiple cavities, heart valve abnormalities, a mildly enlarged liver (hepatomegaly), and a soft out-pouching around the belly-button (umbilical hernia) or lower abdomen (inguinal hernia). Unlike some other types of mucopolysaccharidosis, MPS IV does not affect intelligence. [from <a title="MedlinePlus Genetics" href="https://medlineplus.gov/genetics/" class="defSource" target="_blank">MedlinePlus Genetics</a>]</div>
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0026707[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=44513">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=44513" ref="ncbi_uid=44513">V</a></span></span><span class="TLline">Morquio syndrome</span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0086651[DISCUI]&test_type=Clinical" ref="ncbi_uid=43375">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=43375" target="_blank" href="/omim/253000">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK148668/" ref="ncbi_uid=43375">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=43375" ref="ncbi_uid=43375">V</a></span></span><span class="TLline"><a href="/medgen/43375" ref="tree=GTR&ncbi_uid=43375&link_uid=43375" title="View MedGen record for 'Mucopolysaccharidosis, MPS-IV-A'">Mucopolysaccharidosis, MPS-IV-A</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0086652[DISCUI]&test_type=Clinical" ref="ncbi_uid=43376">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=43376" target="_blank" href="/omim/253010">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK164500/" ref="ncbi_uid=43376">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=43376" ref="ncbi_uid=43376">V</a></span></span><span class="TLline"><a href="/medgen/43376" ref="tree=GTR&ncbi_uid=43376&link_uid=43376" title="View MedGen record for 'Mucopolysaccharidosis, MPS-IV-B'">Mucopolysaccharidosis, MPS-IV-B</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/994785" ref="tree=MeSH" title="MedGen record for Lysosomal storage disease with skeletal involvement">Lysosomal storage disease with skeletal involvement</a></span><ul><li><span class="matched_ds">Morquio syndrome</span><ul><li><span class="TLline"><a href="/medgen/43375" ref="tree=MeSH" title="MedGen record for Mucopolysaccharidosis, MPS-IV-A">Mucopolysaccharidosis, MPS-IV-A</a></span></li><li><span class="TLline"><a href="/medgen/43376" ref="tree=MeSH" title="MedGen record for Mucopolysaccharidosis, MPS-IV-B">Mucopolysaccharidosis, MPS-IV-B</a></span></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32102177">Mucopolysaccharidosis IVA: Diagnosis, Treatment, and Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sawamoto K,
|
||
Álvarez González JV,
|
||
Piechnik M,
|
||
Otero FJ,
|
||
Couce ML,
|
||
Suzuki Y,
|
||
Tomatsu S</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2020 Feb 23;21(4)
|
||
doi: 10.3390/ijms21041517.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32102177" target="_blank">32102177</a><a href="/pmc/articles/PMC7073202" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32014045">Newborn screening for Morquio disease and other lysosomal storage diseases: results from the 8-plex assay for 70,000 newborns.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chien YH,
|
||
Lee NC,
|
||
Chen PW,
|
||
Yeh HY,
|
||
Gelb MH,
|
||
Chiu PC,
|
||
Chu SY,
|
||
Lee CH,
|
||
Lee AR,
|
||
Hwu WL</span><br />
|
||
<span class="medgenPMjournal">Orphanet J Rare Dis</span>
|
||
2020 Feb 3;15(1):38.
|
||
doi: 10.1186/s13023-020-1322-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32014045" target="_blank">32014045</a><a href="/pmc/articles/PMC6998831" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22358740">Clinical overview and treatment options for non-skeletal manifestations of mucopolysaccharidosis type IVA.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hendriksz CJ,
|
||
Al-Jawad M,
|
||
Berger KI,
|
||
Hawley SM,
|
||
Lawrence R,
|
||
Mc Ardle C,
|
||
Summers CG,
|
||
Wright E,
|
||
Braunlin E</span><br />
|
||
<span class="medgenPMjournal">J Inherit Metab Dis</span>
|
||
2013 Mar;36(2):309-22.
|
||
Epub 2012 Feb 23
|
||
doi: 10.1007/s10545-012-9459-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22358740" target="_blank">22358740</a><a href="/pmc/articles/PMC3590399" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22morquio%20syndrome%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (9)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36400977">How did intraoperative neuromonitorization prevent tetraplegia?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sahin MC,
|
||
Ipek EM,
|
||
Zinnuroglu M,
|
||
Borcek AO</span><br />
|
||
<span class="medgenPMjournal">Childs Nerv Syst</span>
|
||
2023 May;39(5):1323-1328.
|
||
Epub 2022 Nov 18
|
||
doi: 10.1007/s00381-022-05748-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36400977" target="_blank">36400977</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32305599">Paralysis Caused by Spinal Cord Injury After Posterior Fossa Surgery: A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yahanda AT,
|
||
Chicoine MR</span><br />
|
||
<span class="medgenPMjournal">World Neurosurg</span>
|
||
2020 Jul;139:151-157.
|
||
Epub 2020 Apr 17
|
||
doi: 10.1016/j.wneu.2020.04.016.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32305599" target="_blank">32305599</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25496828">Diagnostic evaluation, monitoring, and perioperative management of spinal cord compression in patients with Morquio syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Charrow J,
|
||
Alden TD,
|
||
Breathnach CA,
|
||
Frawley GP,
|
||
Hendriksz CJ,
|
||
Link B,
|
||
Mackenzie WG,
|
||
Manara R,
|
||
Offiah AC,
|
||
Solano ML,
|
||
Theroux M</span><br />
|
||
<span class="medgenPMjournal">Mol Genet Metab</span>
|
||
2015 Jan;114(1):11-8.
|
||
Epub 2014 Oct 30
|
||
doi: 10.1016/j.ymgme.2014.10.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25496828" target="_blank">25496828</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22045003">Review of cervical spine anomalies in genetic syndromes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McKay SD,
|
||
Al-Omari A,
|
||
Tomlinson LA,
|
||
Dormans JP</span><br />
|
||
<span class="medgenPMjournal">Spine (Phila Pa 1976)</span>
|
||
2012 Mar 1;37(5):E269-77.
|
||
doi: 10.1097/BRS.0b013e31823b3ded.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22045003" target="_blank">22045003</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17027703">N-acetylgalactosamine-6-sulfatase protein detection in MPS IVA patient and unaffected control samples.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Parkinson-Lawrence EJ,
|
||
Muller VJ,
|
||
Hopwood JJ,
|
||
Brooks DA</span><br />
|
||
<span class="medgenPMjournal">Clin Chim Acta</span>
|
||
2007 Feb;377(1-2):88-91.
|
||
Epub 2006 Sep 1
|
||
doi: 10.1016/j.cca.2006.08.030.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17027703" target="_blank">17027703</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Morquio%20syndrome%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (41)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38520463">Subfoveal Deposits in Morquio Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Aubeleau M,
|
||
David T,
|
||
Gascon P</span><br />
|
||
<span class="medgenPMjournal">Ophthalmol Retina</span>
|
||
2024 Oct;8(10):e30.
|
||
Epub 2024 Mar 23
|
||
doi: 10.1016/j.oret.2024.02.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38520463" target="_blank">38520463</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36115686">Dysplasias in the Child's Spine.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Campbell JW</span><br />
|
||
<span class="medgenPMjournal">Neurosurg Clin N Am</span>
|
||
2022 Jan;33(1S):e1-e10.
|
||
Epub 2022 Aug 6
|
||
doi: 10.1016/j.nec.2022.02.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36115686" target="_blank">36115686</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32102177">Mucopolysaccharidosis IVA: Diagnosis, Treatment, and Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sawamoto K,
|
||
Álvarez González JV,
|
||
Piechnik M,
|
||
Otero FJ,
|
||
Couce ML,
|
||
Suzuki Y,
|
||
Tomatsu S</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2020 Feb 23;21(4)
|
||
doi: 10.3390/ijms21041517.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32102177" target="_blank">32102177</a><a href="/pmc/articles/PMC7073202" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32014045">Newborn screening for Morquio disease and other lysosomal storage diseases: results from the 8-plex assay for 70,000 newborns.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chien YH,
|
||
Lee NC,
|
||
Chen PW,
|
||
Yeh HY,
|
||
Gelb MH,
|
||
Chiu PC,
|
||
Chu SY,
|
||
Lee CH,
|
||
Lee AR,
|
||
Hwu WL</span><br />
|
||
<span class="medgenPMjournal">Orphanet J Rare Dis</span>
|
||
2020 Feb 3;15(1):38.
|
||
doi: 10.1186/s13023-020-1322-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32014045" target="_blank">32014045</a><a href="/pmc/articles/PMC6998831" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6793501">Morquio syndrome: clinical findings in 11 patients with MPS IVA and 2 patients with MPS IVB.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Holzgreve W,
|
||
Gröbe H,
|
||
von Figura K,
|
||
Kresse H,
|
||
Beck H,
|
||
Mattei JF</span><br />
|
||
<span class="medgenPMjournal">Hum Genet</span>
|
||
1981;57(4):360-5.
|
||
doi: 10.1007/BF00281685.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6793501" target="_blank">6793501</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Morquio%20syndrome%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (73)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32305599">Paralysis Caused by Spinal Cord Injury After Posterior Fossa Surgery: A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yahanda AT,
|
||
Chicoine MR</span><br />
|
||
<span class="medgenPMjournal">World Neurosurg</span>
|
||
2020 Jul;139:151-157.
|
||
Epub 2020 Apr 17
|
||
doi: 10.1016/j.wneu.2020.04.016.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32305599" target="_blank">32305599</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22210671">Therapy for the mucopolysaccharidoses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Valayannopoulos V,
|
||
Wijburg FA</span><br />
|
||
<span class="medgenPMjournal">Rheumatology (Oxford)</span>
|
||
2011 Dec;50 Suppl 5:v49-59.
|
||
doi: 10.1093/rheumatology/ker396.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22210671" target="_blank">22210671</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18590267">child with Morquio syndrome and mixed mitral valve disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mettananda DS,
|
||
Fernando AD</span><br />
|
||
<span class="medgenPMjournal">Ceylon Med J</span>
|
||
2008 Mar;53(1):24-5.
|
||
doi: 10.4038/cmj.v53i1.223.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18590267" target="_blank">18590267</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3930102">Glycosaminoglycan excretion in random samples of urine.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Huang KC,
|
||
Sukegawa K,
|
||
Orii T</span><br />
|
||
<span class="medgenPMjournal">Clin Chim Acta</span>
|
||
1985 Sep 30;151(2):141-6.
|
||
doi: 10.1016/0009-8981(85)90317-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3930102" target="_blank">3930102</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4269648">Atlanto-axial subluxation in the Morquio syndrome. Report of a case.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Beighton P,
|
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Craig J</span><br />
|
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<span class="medgenPMjournal">J Bone Joint Surg Br</span>
|
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1973 Aug;55(3):478-81.
|
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<span class="bold">PMID: </span><a href="/pubmed/4269648" target="_blank">4269648</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Morquio%20syndrome%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (13)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33608742">Tracheal narrowing in children and adults with mucopolysaccharidosis type IVA: evaluation with computed tomography angiography.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Averill LW,
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Kecskemethy HH,
|
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Theroux MC,
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Mackenzie WG,
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Pizarro C,
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Bober MB,
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Ditro CP,
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2021 Jun;51(7):1202-1213.
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|
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|
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<span class="bold">PMID: </span><a href="/pubmed/33608742" target="_blank">33608742</a><a href="/pmc/articles/PMC10190165" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32014045">Newborn screening for Morquio disease and other lysosomal storage diseases: results from the 8-plex assay for 70,000 newborns.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chien YH,
|
||
Lee NC,
|
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Chen PW,
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Yeh HY,
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Gelb MH,
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Chiu PC,
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Chu SY,
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Lee CH,
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2020 Feb 3;15(1):38.
|
||
doi: 10.1186/s13023-020-1322-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32014045" target="_blank">32014045</a><a href="/pmc/articles/PMC6998831" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27977582">Spine malformation complex in 3 diverse syndromic entities: Case reports.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kaissi AA,
|
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van Egmond-Fröhlich A,
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Ryabykh S,
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Ochirov P,
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Kenis V,
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Hofstaetter JG,
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Grill F,
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Ganger R,
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<span class="medgenPMjournal">Medicine (Baltimore)</span>
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2016 Dec;95(50):e5505.
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doi: 10.1097/MD.0000000000005505.
|
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<span class="bold">PMID: </span><a href="/pubmed/27977582" target="_blank">27977582</a><a href="/pmc/articles/PMC5268028" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/14608657">Incidence of the mucopolysaccharidoses in Western Australia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nelson J,
|
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Crowhurst J,
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Carey B,
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Greed L</span><br />
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<span class="medgenPMjournal">Am J Med Genet A</span>
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2003 Dec 15;123A(3):310-3.
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doi: 10.1002/ajmg.a.20314.
|
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<span class="bold">PMID: </span><a href="/pubmed/14608657" target="_blank">14608657</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11204070">Dental findings in Morquio syndrome (mucopolysaccharidoses type IVa).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Barker D,
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Welbury RR</span><br />
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<span class="medgenPMjournal">ASDC J Dent Child</span>
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2000 Nov-Dec;67(6):431-3, 407.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11204070" target="_blank">11204070</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Morquio%20syndrome%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (26)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32014045">Newborn screening for Morquio disease and other lysosomal storage diseases: results from the 8-plex assay for 70,000 newborns.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chien YH,
|
||
Lee NC,
|
||
Chen PW,
|
||
Yeh HY,
|
||
Gelb MH,
|
||
Chiu PC,
|
||
Chu SY,
|
||
Lee CH,
|
||
Lee AR,
|
||
Hwu WL</span><br />
|
||
<span class="medgenPMjournal">Orphanet J Rare Dis</span>
|
||
2020 Feb 3;15(1):38.
|
||
doi: 10.1186/s13023-020-1322-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32014045" target="_blank">32014045</a><a href="/pmc/articles/PMC6998831" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28535791">Clinical outcomes in a subpopulation of adults with Morquio A syndrome: results from a long-term extension study of elosulfase alfa.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hughes D,
|
||
Giugliani R,
|
||
Guffon N,
|
||
Jones SA,
|
||
Mengel KE,
|
||
Parini R,
|
||
Matousek R,
|
||
Hawley SM,
|
||
Quartel A</span><br />
|
||
<span class="medgenPMjournal">Orphanet J Rare Dis</span>
|
||
2017 May 23;12(1):98.
|
||
doi: 10.1186/s13023-017-0634-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28535791" target="_blank">28535791</a><a href="/pmc/articles/PMC5442692" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26896739">Synchrotron X-ray diffraction and scanning electron microscopy to understand enamel affected by metabolic disorder mucopolysaccharidosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khan MA,
|
||
Addison O,
|
||
James A,
|
||
Hendriksz CJ,
|
||
Al-Jawad M</span><br />
|
||
<span class="medgenPMjournal">Micron</span>
|
||
2016 Apr;83:48-53.
|
||
Epub 2016 Jan 12
|
||
doi: 10.1016/j.micron.2016.01.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26896739" target="_blank">26896739</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22231379">Intellectual and neurological functioning in Morquio syndrome (MPS IVa).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Davison JE,
|
||
Kearney S,
|
||
Horton J,
|
||
Foster K,
|
||
Peet AC,
|
||
Hendriksz CJ</span><br />
|
||
<span class="medgenPMjournal">J Inherit Metab Dis</span>
|
||
2013 Mar;36(2):323-8.
|
||
Epub 2012 Jan 10
|
||
doi: 10.1007/s10545-011-9430-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22231379" target="_blank">22231379</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19043137">Total knee replacements in a patient with the Morquio syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Atinga M,
|
||
Hamer AJ</span><br />
|
||
<span class="medgenPMjournal">J Bone Joint Surg Br</span>
|
||
2008 Dec;90(12):1631-3.
|
||
doi: 10.1302/0301-620X.90B12.20641.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19043137" target="_blank">19043137</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Morquio%20syndrome%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (32)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/32305599">Paralysis Caused by Spinal Cord Injury After Posterior Fossa Surgery: A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yahanda AT,
|
||
Chicoine MR</span><br />
|
||
<span class="medgenPMjournal">World Neurosurg</span>
|
||
2020 Jul;139:151-157.
|
||
Epub 2020 Apr 17
|
||
doi: 10.1016/j.wneu.2020.04.016.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32305599" target="_blank">32305599</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Morquio%20syndrome%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
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|
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|
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|
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<div class="supplemental col three_col last">
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0026707%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (1)</a></li>
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<li><a href="/gtr/tests?term=C0026707%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (1)</a></li>
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<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0026707%5bDISCUI%5d" target="_blank">See all (1)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=582" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Morquio%20syndrome" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22morquio%20syndrome%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Morquio+Syndrome/4875" target="_blank">Genetic Alliance</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Morquio%20syndrome" target="_blank">MedlinePlus</a></li><li><a href="https://medlineplus.gov/genetics/condition/mucopolysaccharidosis-type-iv" target="_blank">MedlinePlusGenetics (GHR)</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/12562/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
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<a href="/pubmed/clinical?term=Morquio%20syndrome" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
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<a href="/pubmed?term=Morquio%20syndrome%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
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<h3>Related information</h3>
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<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=44513" ref="log$=recordlinks">ClinVar</a>
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<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
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</li>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0026707[DISCUI]" ref="log$=recordlinks">GTR</a>
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<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0026707[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
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<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/mesh?LinkName=medgen_mesh&from_uid=44513" ref="log$=recordlinks">MeSH</a>
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