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<meta name="keywords" content="C1836623, decreased circulating cortisol level, decreased cortisol production, finding, glucocorticoid insufficiency, hypocortisolemia, hypocortisolism, low blood cortisol level, low plasma cortisol, low to undetectable plasma cortisol, plasma cortisol low, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Abnormally reduced concentration of cortisol in the blood." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=322961
|
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ConceptID=C1836623
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Decreased circulating cortisol level</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>322961</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1836623</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Low plasma cortisol; Low to undetectable plasma cortisol</td></tr>
|
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<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0008163">HP:0008163</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Abnormally reduced concentration of cortisol in the blood. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Decreased circulating cortisol level</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/893021" ref="tree=MeSH" title="MedGen record for Abnormality of the endocrine system">Abnormality of the endocrine system</a></span><ul><li><span class="TLline"><a href="/medgen/871176" ref="tree=MeSH" title="MedGen record for Abnormal circulating hormone concentration">Abnormal circulating hormone concentration</a></span><ul><li><span class="TLline"><a href="/medgen/868638" ref="tree=MeSH" title="MedGen record for Abnormality of circulating glucocorticoid level">Abnormality of circulating glucocorticoid level</a></span><ul><li><span class="TLline"><a href="/medgen/868804" ref="tree=MeSH" title="MedGen record for Abnormality of circulating cortisol level">Abnormality of circulating cortisol level</a></span><ul><li><span class="matched_ds">Decreased circulating cortisol level</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_120514"><div><strong>Pallister-Hall syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>120514</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0265220</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">GLI3-related Pallister-Hall syndrome (GLI3-PHS) is characterized by a spectrum of anomalies ranging from polydactyly, asymptomatic bifid epiglottis, and hypothalamic hamartoma at the mild end to laryngotracheal cleft with neonatal lethality at the severe end. Individuals with mild GLI3-PHS may be incorrectly diagnosed as having isolated postaxial polydactyly type A. Individuals with GLI3-PHS can have pituitary insufficiency and may die as neonates from undiagnosed and untreated adrenal insufficiency.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/120514">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_82889"><div><strong>Glucocorticoid deficiency with achalasia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82889</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0271742</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Triple A syndrome is an inherited condition characterized by three specific features: achalasia, Addison disease, and alacrima. Achalasia is a disorder that affects the ability to move food through the esophagus, the tube that carries food from the throat to the stomach. It can lead to severe feeding difficulties and low blood glucose (hypoglycemia). Addison disease, also known as primary adrenal insufficiency, is caused by abnormal function of the small hormone-producing glands on top of each kidney (adrenal glands). The main features of Addison disease include fatigue, loss of appetite, weight loss, low blood pressure, and darkening of the skin. The third major feature of triple A syndrome is a reduced or absent ability to secrete tears (alacrima). Most people with triple A syndrome have all three of these features, although some have only two.\n\nMany of the features of triple A syndrome are caused by dysfunction of the autonomic nervous system. This part of the nervous system controls involuntary body processes such as digestion, blood pressure, and body temperature. People with triple A syndrome often experience abnormal sweating, difficulty regulating blood pressure, unequal pupil size (anisocoria), and other signs and symptoms of autonomic nervous system dysfunction (dysautonomia).\n\nPeople with this condition may have other neurological abnormalities, such as developmental delay, intellectual disability, speech problems (dysarthria), and a small head size (microcephaly). In addition, affected individuals commonly experience muscle weakness, movement problems, and nerve abnormalities in their extremities (peripheral neuropathy). Some develop optic atrophy, which is the degeneration (atrophy) of the nerves that carry information from the eyes to the brain. Many of the neurological symptoms of triple A syndrome worsen over time.\n\nPeople with triple A syndrome frequently develop a thickening of the outer layer of skin (hyperkeratosis) on the palms of their hands and the soles of their feet. Other skin abnormalities may also be present in people with this condition.\n\nAlacrima is usually the first noticeable sign of triple A syndrome, as it becomes apparent early in life that affected children produce little or no tears while crying. They develop Addison disease and achalasia during childhood or adolescence, and most of the neurologic features of triple A syndrome begin during adulthood. The signs and symptoms of this condition vary among affected individuals, even among members of the same family.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/82889">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_137968"><div><strong>Congenital isolated adrenocorticotropic hormone deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>137968</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0342388</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital isolated adrenocorticotropic hormone deficiency (IAD) is characterized by severe hypoglycemia in the neonatal period, associated with seizures in about half of cases, prolonged cholestatic jaundice, and very low plasma ACTH levels with no significant response to corticotropin-releasing hormone (CRH; 122560). Plasma cortisol levels are also extremely low (Vallette-Kasic et al., 2005). TBX19 is required for initiation of transcription of the POMC gene (176830), which produces the precursor peptide from which ACTH is derived (Lamolet et al., 2001).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/137968">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_87442"><div><strong>Congenital adrenal hypoplasia, X-linked</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>87442</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0342482</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">NR0B1-related adrenal hypoplasia congenita includes both X-linked adrenal hypoplasia congenita (X-linked AHC) and Xp21 deletion (previously called complex glycerol kinase deficiency). X-linked AHC is characterized by primary adrenal insufficiency and/or hypogonadotropic hypogonadism (HH). Adrenal insufficiency is acute infantile onset (average age 3 weeks) in approximately 60% of affected males and childhood onset (ages 1-9 years) in approximately 40%. HH typically manifests in a male with adrenal insufficiency as delayed puberty (i.e., onset age >14 years) and less commonly as arrested puberty at about Tanner Stage 3. Rarely, X-linked AHC manifests initially in early adulthood as delayed-onset adrenal insufficiency, partial HH, and/or infertility. Heterozygous females very occasionally have manifestations of adrenal insufficiency or hypogonadotropic hypogonadism. Xp21 deletion includes deletion of NR0B1 (causing X-linked AHC) and GK (causing glycerol kinase deficiency), and in some cases deletion of DMD (causing Duchenne muscular dystrophy). Developmental delay has been reported in males with Xp21 deletion when the deletion extends proximally to include DMD or when larger deletions extend distally to include IL1RAPL1 and DMD.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/87442">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_318777"><div><strong>Obesity due to prohormone convertase I deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>318777</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1833053</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Proprotein convertase-1/3 deficiency is an autosomal recessive disorder characterized by neonatal severe generalized malabsorptive diarrhea and failure to thrive. As the disease progresses, additional endocrine abnormalities develop, including diabetes insipidus, growth hormone deficiency, primary hypogonadism, adrenal insufficiency, and hypothyroidism (summary by Wilschanski et al., 2014).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/318777">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_332252"><div><strong>Glucocorticoid deficiency 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>332252</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1836621</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial isolated glucocorticoid deficiency (GCCD) is an adrenocortical failure characterized by very low levels of plasma cortisol despite high levels of plasma adrenocorticotropin (ACTH). Moreover, the adrenal response to ACTH is severely impaired. There is no mineralocorticoid deficiency and the renin-angiotensin system is not affected (summary by Genin et al., 2002). For a general phenotypic description and a discussion of genetic heterogeneity of familial glucocorticoid deficiency, see GCCD1 (202200).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/332252">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_338045"><div><strong>Mitochondrial DNA depletion syndrome 6 (hepatocerebral type)</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>338045</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1850406</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">MPV17-related mitochondrial DNA (mtDNA) maintenance defect presents in the vast majority of affected individuals as an early-onset encephalohepatopathic (hepatocerebral) disease that is typically associated with mtDNA depletion, particularly in the liver. A later-onset neuromyopathic disease characterized by myopathy and neuropathy, and associated with multiple mtDNA deletions in muscle, has also rarely been described. MPV17-related mtDNA maintenance defect, encephalohepatopathic form is characterized by: Hepatic manifestations (liver dysfunction that typically progresses to liver failure, cholestasis, hepatomegaly, and steatosis); Neurologic involvement (developmental delay, hypotonia, microcephaly, and motor and sensory peripheral neuropathy); Gastrointestinal manifestations (gastrointestinal dysmotility, feeding difficulties, and failure to thrive); and Metabolic derangements (lactic acidosis and hypoglycemia). Less frequent manifestations include renal tubulopathy, nephrocalcinosis, and hypoparathyroidism. Progressive liver disease often leads to death in infancy or early childhood. Hepatocellular carcinoma has been reported.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/338045">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_343831"><div><strong>Corticosteroid-binding globulin deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>343831</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1852529</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Corticosteroid-binding globulin (CBG) deficiency is a rare endocrine disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo- or hypertension and muscle fatigue (summary by Buss et al., 2007).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/343831">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_341863"><div><strong>Obesity due to pro-opiomelanocortin deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>341863</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1857854</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Early-onset obesity with adrenal insuficiency and red hair (OBAIRH) is an autosomal recessive endocrine disorder characterized by early-onset obesity due to severe hyperphagia, pigmentary abnormalities, mainly pale skin and red hair, and secondary hypocortisolism. In the neonatal period, affected individuals are prone to hypoglycemia, hyperbilirubinemia, and cholestasis that may result in death if not treated. The disorder results from mutation in the POMC gene, which encodes a preproprotein that is processed into a range of bioactive peptides, including alpha-melanocyte-stimulating hormone (MSH) and ACTH (summary by Kuhnen et al., 2016 and Clement et al., 2008).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/341863">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_461449"><div><strong>Antley-Bixler syndrome with genital anomalies and disordered steroidogenesis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>461449</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3150099</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Cytochrome P450 oxidoreductase deficiency (PORD) is a disorder of steroidogenesis with a broad phenotypic spectrum including cortisol deficiency, altered sex steroid synthesis, disorders of sex development (DSD), and skeletal malformations of the Antley-Bixler syndrome (ABS) phenotype. Cortisol deficiency is usually partial, with some baseline cortisol production but failure to mount an adequate cortisol response in stress. Mild mineralocorticoid excess can be present and causes arterial hypertension, usually presenting in young adulthood. Manifestations of altered sex steroid synthesis include ambiguous genitalia/DSD in both males and females, large ovarian cysts in females, poor masculinization and delayed puberty in males, and maternal virilization during pregnancy with an affected fetus. Skeletal malformations can manifest as craniosynostosis, mid-face retrusion with proptosis and choanal stenosis or atresia, low-set dysplastic ears with stenotic external auditory canals, hydrocephalus, radiohumeral synostosis, neonatal fractures, congenital bowing of the long bones, joint contractures, arachnodactyly, and clubfeet; other anomalies observed include urinary tract anomalies (renal pelvic dilatation, vesicoureteral reflux). Cognitive impairment is of minor concern and likely associated with the severity of malformations; studies of developmental outcomes are lacking.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/461449">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766501"><div><strong>Glucocorticoid deficiency 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766501</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3553587</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial glucocorticoid deficiency (GCCD) is a rare autosomal recessive disorder characterized by an inability of the adrenal cortex to produce cortisol in response to stimulation by adrenocorticotropic hormone (ACTH). Affected individuals typically present within the first few months of life with symptoms related to cortisol deficiency, including failure to thrive, recurrent illnesses or infections, hypoglycemia, convulsions, and shock. The disease is life-threatening if untreated (summary by Meimaridou et al., 2012). For a discussion of genetic heterogeneity of familial glucocorticoid deficiency, see GCCD1 (202200).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766501">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_885551"><div><strong>Glucocorticoid deficiency 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>885551</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4049650</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial glucocorticoid deficiency (GCCD) is an autosomal recessive disorder resulting from defects in the action of adrenocorticotropic hormone (ACTH) to stimulate glucocorticoid synthesis in the adrenal. Production of mineralocorticoids by the adrenal is normal. Patients present in early life with low or undetectable cortisol and, because of the failure of the negative feedback loop to the pituitary and hypothalamus, grossly elevated ACTH levels (summary by Clark et al., 2009). Genetic Heterogeneity of Familial Glucocorticoid Deficiency Familial glucocorticoid deficiency-2 (GCCD2; 607398) is caused by mutation in the MRAP gene (609196) on chromosome 21q22. GCCD3 (609197) has been mapped to chromosome 8q11.2-q13.2. GCCD4 with or without mineralocorticoid deficiency (614736) is caused by mutation in the NNT gene (607878) on chromosome 5p12. GCCD5 (617825) is caused by mutation in the TXNRD2 gene (606448) on chromosome 22q11.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/885551">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_891117"><div><strong>Glucocorticoid deficiency 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>891117</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4049714</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial glucocorticoid deficiency is an autosomal recessive disorder resulting from resistance to the action of adrenocorticotropin (ACTH) on the adrenal cortex, which stimulates glucocorticoid production. Affected individuals are deficient in cortisol and, if untreated, are likely to succumb to hypoglycemia or overwhelming infection in infancy or childhood (summary by Metherell et al., 2005). For a general phenotypic description and a discussion of genetic heterogeneity of familial glucocorticoid deficiency, see GCCD1 (202200).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/891117">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1614419"><div><strong>Glucocorticoid deficiency 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1614419</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4540522</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial glucocorticoid deficiency-5 (GCCD5) is characterized by resistance to adrenocorticotropic hormone (ACTH) and isolated glucocorticoid deficiency, with typical biochemical findings of low serum cortisol levels and high plasma ACTH. Patients commonly present with hyperpigmentation (Prasad et al., 2014). For a discussion of genetic heterogeneity of familial glucocorticoid deficiency, see GCCD1 (202200).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1614419">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1714731"><div><strong>Combined oxidative phosphorylation deficiency 40</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1714731</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5394232</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Combined oxidative phosphorylation deficiency-40 (COXPD40) is an autosomal recessive mitochondrial disorder with onset in utero or soon after birth. Affected individuals have severe hypertrophic cardiomyopathy, poor growth, and sensorineural hearing loss. Laboratory studies show evidence of mitochondrial dysfunction, such as lactic acidosis. Patient-derived tissues and cells show variably decreased activities of mitochondrial respiratory complexes I, III, IV, and V. The disorder is lethal, with no reported patients surviving past infancy (summary by Friederich et al., 2018). For a discussion of genetic heterogeneity of combined oxidative phosphorylation deficiency, see COXPD1 (609060).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1714731">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1711853"><div><strong>Combined oxidative phosphorylation deficiency 41</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1711853</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5394236</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1711853">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1709379"><div><strong>Combined oxidative phosphorylation deficiency 42</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1709379</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5394237</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Combined oxidative phosphorylation deficiency-42 (COXPD42) is an autosomal recessive metabolic disorder characterized by onset of cardiomyopathy, respiratory insufficiency, lactic metabolic acidosis, and anemia in the first months of life. Patient tissue shows variable impairment of mitochondrial oxidative phosphorylation affecting mtDNA-encoded subunits I, III, and IV. All reported affected infants have died in the first year of life (summary by Friederich et al., 2018). For a discussion of genetic heterogeneity of combined oxidative phosphorylation deficiency, see COXPD1 (609060).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1709379">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1841013"><div><strong>Neurooculorenal syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1841013</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5830377</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Neurooculorenal syndrome (NORS) is an autosomal recessive developmental disorder with highly variable clinical manifestations involving several organ systems. Some affected individuals present in utero with renal agenesis and structural brain abnormalities incompatible with life, whereas others present in infancy with a neurodevelopmental disorder characterized by global developmental delay and dysmorphic facial features that may be associated with congenital anomalies of the kidney and urinary tract (CAKUT). Additional more variable features may include ocular anomalies, most commonly strabismus, congenital heart defects, and pituitary hormone deficiency. Brain imaging usually shows structural midline defects, including dysgenesis of the corpus callosum and hindbrain. There is variation in the severity, manifestations, and expressivity of the phenotype, even within families (Rasmussen et al., 2018; Munch et al., 2022).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1841013">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_461449" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Antley-Bixler syndrome with genital anomalies and disordered steroidogenesis</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1714731" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Combined oxidative phosphorylation deficiency 40</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1711853" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Combined oxidative phosphorylation deficiency 41</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1709379" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Combined oxidative phosphorylation deficiency 42</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_87442" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Congenital adrenal hypoplasia, X-linked</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (18)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_137968" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Congenital isolated adrenocorticotropic hormone deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_343831" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Corticosteroid-binding globulin deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_885551" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Glucocorticoid deficiency 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_891117" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Glucocorticoid deficiency 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_332252" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Glucocorticoid deficiency 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766501" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Glucocorticoid deficiency 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1614419" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Glucocorticoid deficiency 5</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_82889" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Glucocorticoid deficiency with achalasia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_338045" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Mitochondrial DNA depletion syndrome 6 (hepatocerebral type)</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1841013" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurooculorenal syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_341863" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Obesity due to pro-opiomelanocortin deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_318777" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Obesity due to prohormone convertase I deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_120514" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pallister-Hall syndrome</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37395895">Association of serum cortisol and cortisone levels and risk of recurrence after endocrine treatment in breast cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang F,
|
||
Giskeødegård GF,
|
||
Skarra S,
|
||
Engstrøm MJ,
|
||
Hagen L,
|
||
Geisler J,
|
||
Mikkola TS,
|
||
Tikkanen MJ,
|
||
Debik J,
|
||
Reidunsdatter RJ,
|
||
Bathen TF</span><br />
|
||
<span class="medgenPMjournal">Clin Exp Med</span>
|
||
2023 Nov;23(7):3883-3893.
|
||
Epub 2023 Jul 3
|
||
doi: 10.1007/s10238-023-01109-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37395895" target="_blank">37395895</a><a href="/pmc/articles/PMC10618334" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34056961">Continuous Etomidate for the Management of Cushing's Syndrome Complicated by Pulmonary Nocardiosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hays WB,
|
||
Czosnowski Q</span><br />
|
||
<span class="medgenPMjournal">J Pharm Pract</span>
|
||
2022 Dec;35(6):1057-1059.
|
||
Epub 2021 May 31
|
||
doi: 10.1177/08971900211017487.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34056961" target="_blank">34056961</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27225960">Considerations in the management of hypoxemic respiratory failure and persistent pulmonary hypertension in term and late preterm neonates.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lakshminrusimha S,
|
||
Konduri GG,
|
||
Steinhorn RH</span><br />
|
||
<span class="medgenPMjournal">J Perinatol</span>
|
||
2016 Jun;36 Suppl 2:S12-9.
|
||
doi: 10.1038/jp.2016.44.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27225960" target="_blank">27225960</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(decreased%20circulating%20cortisol%20level)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (12)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37603200">Effect of Soy Protein Supplementation on Muscle Adaptations, Metabolic and Antioxidant Status, Hormonal Response, and Exercise Performance of Active Individuals and Athletes: A Systematic Review of Randomised Controlled Trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zare R,
|
||
Devrim-Lanpir A,
|
||
Guazzotti S,
|
||
Ali Redha A,
|
||
Prokopidis K,
|
||
Spadaccini D,
|
||
Cannataro R,
|
||
Cione E,
|
||
Henselmans M,
|
||
Aragon AA</span><br />
|
||
<span class="medgenPMjournal">Sports Med</span>
|
||
2023 Dec;53(12):2417-2446.
|
||
Epub 2023 Aug 21
|
||
doi: 10.1007/s40279-023-01899-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37603200" target="_blank">37603200</a><a href="/pmc/articles/PMC10687132" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34579009">L-Citrulline Supplementation and Exercise in the Management of Sarcopenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Caballero-García A,
|
||
Pascual-Fernández J,
|
||
Noriega-González DC,
|
||
Bello HJ,
|
||
Pons-Biescas A,
|
||
Roche E,
|
||
Córdova-Martínez A</span><br />
|
||
<span class="medgenPMjournal">Nutrients</span>
|
||
2021 Sep 8;13(9)
|
||
doi: 10.3390/nu13093133.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34579009" target="_blank">34579009</a><a href="/pmc/articles/PMC8465698" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31151228">Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jamshed H,
|
||
Beyl RA,
|
||
Della Manna DL,
|
||
Yang ES,
|
||
Ravussin E,
|
||
Peterson CM</span><br />
|
||
<span class="medgenPMjournal">Nutrients</span>
|
||
2019 May 30;11(6)
|
||
doi: 10.3390/nu11061234.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31151228" target="_blank">31151228</a><a href="/pmc/articles/PMC6627766" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15730338">The mechanisms of massage and effects on performance, muscle recovery and injury prevention.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Weerapong P,
|
||
Hume PA,
|
||
Kolt GS</span><br />
|
||
<span class="medgenPMjournal">Sports Med</span>
|
||
2005;35(3):235-56.
|
||
doi: 10.2165/00007256-200535030-00004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15730338" target="_blank">15730338</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8510388">Potassium supplementation ameliorates mineralocorticoid-induced sodium retention.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Krishna GG,
|
||
Kapoor SC</span><br />
|
||
<span class="medgenPMjournal">Kidney Int</span>
|
||
1993 May;43(5):1097-103.
|
||
doi: 10.1038/ki.1993.154.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8510388" target="_blank">8510388</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20cortisol%20level%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (283)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/23253896">Hair cortisol, stress exposure, and mental health in humans: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Staufenbiel SM,
|
||
Penninx BW,
|
||
Spijker AT,
|
||
Elzinga BM,
|
||
van Rossum EF</span><br />
|
||
<span class="medgenPMjournal">Psychoneuroendocrinology</span>
|
||
2013 Aug;38(8):1220-35.
|
||
Epub 2012 Dec 17
|
||
doi: 10.1016/j.psyneuen.2012.11.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23253896" target="_blank">23253896</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21126557">Oxytocin increases autonomic cardiac control: moderation by loneliness.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Norman GJ,
|
||
Cacioppo JT,
|
||
Morris JS,
|
||
Malarkey WB,
|
||
Berntson GG,
|
||
Devries AC</span><br />
|
||
<span class="medgenPMjournal">Biol Psychol</span>
|
||
2011 Mar;86(3):174-80.
|
||
Epub 2010 Nov 30
|
||
doi: 10.1016/j.biopsycho.2010.11.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21126557" target="_blank">21126557</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10818396">Maternal hypothalamic-pituitary-adrenal axis in pregnancy and the postpartum period. Postpartum-related disorders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mastorakos G,
|
||
Ilias I</span><br />
|
||
<span class="medgenPMjournal">Ann N Y Acad Sci</span>
|
||
2000;900:95-106.
|
||
doi: 10.1111/j.1749-6632.2000.tb06220.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10818396" target="_blank">10818396</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2674189">Hirsutism, its pathogenesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Breckwoldt M,
|
||
Zahradnik HP,
|
||
Wieacker P</span><br />
|
||
<span class="medgenPMjournal">Hum Reprod</span>
|
||
1989 Aug;4(6):601-4.
|
||
doi: 10.1093/oxfordjournals.humrep.a136950.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2674189" target="_blank">2674189</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3312681">Reproductive immunology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gurka G,
|
||
Rocklin RE</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
1987 Nov 27;258(20):2983-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3312681" target="_blank">3312681</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20cortisol%20level%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (116)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37603200">Effect of Soy Protein Supplementation on Muscle Adaptations, Metabolic and Antioxidant Status, Hormonal Response, and Exercise Performance of Active Individuals and Athletes: A Systematic Review of Randomised Controlled Trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zare R,
|
||
Devrim-Lanpir A,
|
||
Guazzotti S,
|
||
Ali Redha A,
|
||
Prokopidis K,
|
||
Spadaccini D,
|
||
Cannataro R,
|
||
Cione E,
|
||
Henselmans M,
|
||
Aragon AA</span><br />
|
||
<span class="medgenPMjournal">Sports Med</span>
|
||
2023 Dec;53(12):2417-2446.
|
||
Epub 2023 Aug 21
|
||
doi: 10.1007/s40279-023-01899-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37603200" target="_blank">37603200</a><a href="/pmc/articles/PMC10687132" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34579009">L-Citrulline Supplementation and Exercise in the Management of Sarcopenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Caballero-García A,
|
||
Pascual-Fernández J,
|
||
Noriega-González DC,
|
||
Bello HJ,
|
||
Pons-Biescas A,
|
||
Roche E,
|
||
Córdova-Martínez A</span><br />
|
||
<span class="medgenPMjournal">Nutrients</span>
|
||
2021 Sep 8;13(9)
|
||
doi: 10.3390/nu13093133.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34579009" target="_blank">34579009</a><a href="/pmc/articles/PMC8465698" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31151228">Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jamshed H,
|
||
Beyl RA,
|
||
Della Manna DL,
|
||
Yang ES,
|
||
Ravussin E,
|
||
Peterson CM</span><br />
|
||
<span class="medgenPMjournal">Nutrients</span>
|
||
2019 May 30;11(6)
|
||
doi: 10.3390/nu11061234.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31151228" target="_blank">31151228</a><a href="/pmc/articles/PMC6627766" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8510388">Potassium supplementation ameliorates mineralocorticoid-induced sodium retention.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Krishna GG,
|
||
Kapoor SC</span><br />
|
||
<span class="medgenPMjournal">Kidney Int</span>
|
||
1993 May;43(5):1097-103.
|
||
doi: 10.1038/ki.1993.154.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8510388" target="_blank">8510388</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8256661">Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hodges SJ,
|
||
Akesson K,
|
||
Vergnaud P,
|
||
Obrant K,
|
||
Delmas PD</span><br />
|
||
<span class="medgenPMjournal">J Bone Miner Res</span>
|
||
1993 Oct;8(10):1241-5.
|
||
doi: 10.1002/jbmr.5650081012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8256661" target="_blank">8256661</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20cortisol%20level%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (292)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32401103">Low glucocorticoids in stress-related disorders: the role of inflammation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sarapultsev A,
|
||
Sarapultsev P,
|
||
Dremencov E,
|
||
Komelkova M,
|
||
Tseilikman O,
|
||
Tseilikman V</span><br />
|
||
<span class="medgenPMjournal">Stress</span>
|
||
2020 Nov;23(6):651-661.
|
||
Epub 2020 May 22
|
||
doi: 10.1080/10253890.2020.1766020.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32401103" target="_blank">32401103</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29357129">Adrenocortical Stress Response during the Course of Critical Illness.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Peeters B,
|
||
Langouche L,
|
||
Van den Berghe G</span><br />
|
||
<span class="medgenPMjournal">Compr Physiol</span>
|
||
2017 Dec 12;8(1):283-298.
|
||
doi: 10.1002/cphy.c170022.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29357129" target="_blank">29357129</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21126557">Oxytocin increases autonomic cardiac control: moderation by loneliness.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Norman GJ,
|
||
Cacioppo JT,
|
||
Morris JS,
|
||
Malarkey WB,
|
||
Berntson GG,
|
||
Devries AC</span><br />
|
||
<span class="medgenPMjournal">Biol Psychol</span>
|
||
2011 Mar;86(3):174-80.
|
||
Epub 2010 Nov 30
|
||
doi: 10.1016/j.biopsycho.2010.11.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21126557" target="_blank">21126557</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17875353">Relative adrenal insufficiency in post-cardiac arrest shock is under-recognized.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miller JB,
|
||
Donnino MW,
|
||
Rogan M,
|
||
Goyal N</span><br />
|
||
<span class="medgenPMjournal">Resuscitation</span>
|
||
2008 Feb;76(2):221-5.
|
||
Epub 2007 Sep 17
|
||
doi: 10.1016/j.resuscitation.2007.07.034.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17875353" target="_blank">17875353</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1737456">Hormonal responses to trauma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Woolf PD</span><br />
|
||
<span class="medgenPMjournal">Crit Care Med</span>
|
||
1992 Feb;20(2):216-26.
|
||
doi: 10.1097/00003246-199202000-00011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1737456" target="_blank">1737456</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20cortisol%20level%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (90)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/21126557">Oxytocin increases autonomic cardiac control: moderation by loneliness.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Norman GJ,
|
||
Cacioppo JT,
|
||
Morris JS,
|
||
Malarkey WB,
|
||
Berntson GG,
|
||
Devries AC</span><br />
|
||
<span class="medgenPMjournal">Biol Psychol</span>
|
||
2011 Mar;86(3):174-80.
|
||
Epub 2010 Nov 30
|
||
doi: 10.1016/j.biopsycho.2010.11.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21126557" target="_blank">21126557</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18827585">The impact of music on hypermetabolism in critical illness.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nelson A,
|
||
Hartl W,
|
||
Jauch KW,
|
||
Fricchione GL,
|
||
Benson H,
|
||
Warshaw AL,
|
||
Conrad C</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Clin Nutr Metab Care</span>
|
||
2008 Nov;11(6):790-4.
|
||
doi: 10.1097/MCO.0b013e328314dd01.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18827585" target="_blank">18827585</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15730338">The mechanisms of massage and effects on performance, muscle recovery and injury prevention.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Weerapong P,
|
||
Hume PA,
|
||
Kolt GS</span><br />
|
||
<span class="medgenPMjournal">Sports Med</span>
|
||
2005;35(3):235-56.
|
||
doi: 10.2165/00007256-200535030-00004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15730338" target="_blank">15730338</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10818396">Maternal hypothalamic-pituitary-adrenal axis in pregnancy and the postpartum period. Postpartum-related disorders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mastorakos G,
|
||
Ilias I</span><br />
|
||
<span class="medgenPMjournal">Ann N Y Acad Sci</span>
|
||
2000;900:95-106.
|
||
doi: 10.1111/j.1749-6632.2000.tb06220.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10818396" target="_blank">10818396</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1737456">Hormonal responses to trauma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Woolf PD</span><br />
|
||
<span class="medgenPMjournal">Crit Care Med</span>
|
||
1992 Feb;20(2):216-26.
|
||
doi: 10.1097/00003246-199202000-00011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1737456" target="_blank">1737456</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20cortisol%20level%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (252)</a></div></div>
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<div class="nl"><a target="_blank" href="/pubmed/37603200">Effect of Soy Protein Supplementation on Muscle Adaptations, Metabolic and Antioxidant Status, Hormonal Response, and Exercise Performance of Active Individuals and Athletes: A Systematic Review of Randomised Controlled Trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zare R,
|
||
Devrim-Lanpir A,
|
||
Guazzotti S,
|
||
Ali Redha A,
|
||
Prokopidis K,
|
||
Spadaccini D,
|
||
Cannataro R,
|
||
Cione E,
|
||
Henselmans M,
|
||
Aragon AA</span><br />
|
||
<span class="medgenPMjournal">Sports Med</span>
|
||
2023 Dec;53(12):2417-2446.
|
||
Epub 2023 Aug 21
|
||
doi: 10.1007/s40279-023-01899-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37603200" target="_blank">37603200</a><a href="/pmc/articles/PMC10687132" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34342920">Effects of dehydroepiandrosterone (DHEA) supplementation on cortisol, leptin, adiponectin, and liver enzyme levels: A systematic review and meta-analysis of randomised clinical trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chen H,
|
||
Jin Z,
|
||
Sun C,
|
||
Santos HO,
|
||
Kord Varkaneh H</span><br />
|
||
<span class="medgenPMjournal">Int J Clin Pract</span>
|
||
2021 Nov;75(11):e14698.
|
||
Epub 2021 Aug 9
|
||
doi: 10.1111/ijcp.14698.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34342920" target="_blank">34342920</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23253896">Hair cortisol, stress exposure, and mental health in humans: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Staufenbiel SM,
|
||
Penninx BW,
|
||
Spijker AT,
|
||
Elzinga BM,
|
||
van Rossum EF</span><br />
|
||
<span class="medgenPMjournal">Psychoneuroendocrinology</span>
|
||
2013 Aug;38(8):1220-35.
|
||
Epub 2012 Dec 17
|
||
doi: 10.1016/j.psyneuen.2012.11.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23253896" target="_blank">23253896</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20cortisol%20level%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3)</a></div></div>
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