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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="books">Books</option><option value="pubmed">PubMed</option><option value="pmc">PMC</option><option value="nuccore" class="last" data-ac_dict="nuccore">Nucleotide</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" selected="selected" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'88175',linkname:'',idsfromresult:'5663',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="genomic">Genomic</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="alt-splicing">Alternatively spliced</a></li><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li><li class="fil_val"><a href="#" data-value_id="gene-type-protein-coding">Protein-coding</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="seq-ccds">CCDS</a></li><li class="fil_val"><a href="#" data-value_id="seq-ensembl">Ensembl</a></li><li class="fil_val"><a href="#" data-value_id="refseq">RefSeq</a></li><li class="fil_val"><a href="#" data-value_id="seq-refseqgene">RefSeqGene</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67dbb4994f3d5e000deafbcc" data-hid="MCID_67d9f06cb98da1549268b4db" data-qky="88175" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">PSEN1</span> presenilin 1 [ <em class="tax">Homo sapiens</em> (human)
]
</h1>
<span class="geneid">Gene ID: 5663, updated on
8-Mar-2025</span>
</div>
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<p style="margin-left:5px;">In addition, your package will include a detailed data report in both TSV and JSONL formats.</p>
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<div class="rprt-section gene-summary">
<section class="rprt-section-header" id="summary">
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<div id="summaryDiv" class="section">
<dl id="summaryDl">
<dt class="noline"> Official
Symbol</dt>
<dd class="noline">PSEN1<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt> Official
Full Name</dt>
<dd>presenilin 1<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
<dt>Primary source</dt>
<dd>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9508" data-gblink-text="Ensembl">HGNC:HGNC:9508</a>
</dd>
<dt>See related</dt>
<dd>
<a href="http://www.ensembl.org/id/ENSG00000080815" data-gblink-text="Ensembl" class="genome-browser-link" data-genome-browser-link-sort="5" data-gb-url="http://www.ensembl.org/loc/ENSG00000080815">Ensembl:ENSG00000080815</a>
<a href="https://www.ncbi.nlm.nih.gov/omim/104311" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=104311">MIM:104311;</a>
<a href="https://www.alliancegenome.org/gene/HGNC:9508" data-gblink-text="Ensembl" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=HGNC:9508">AllianceGenome:HGNC:9508</a>
</dd>
<dt>Gene type</dt>
<dd>protein coding</dd>
<dt>RefSeq status</dt>
<dd>REVIEWED</dd>
<dt>Organism</dt>
<dd class="tax">
<a href="/Taxonomy/Browser/wwwtax.cgi?id=9606" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=9606">Homo sapiens</a>
</dd>
<dt>Lineage</dt>
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dd>
<dt>Also known as</dt>
<dd>AD3; FAD; PS1; PS-1; S182; CMD1U; PSNL1; ACNINV3</dd>
<dt>Summary</dt>
<dd>Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]</dd>
<dt>Expression</dt>
<dd>Ubiquitous expression in colon (RPKM 14.6), small intestine (RPKM 14.0) and 25 other tissues <a href="#gene-expression">See more</a></dd>
<dt>Orthologs</dt>
<dd class="ortholog-links">
<a href="https://www.ncbi.nlm.nih.gov/gene/19164">mouse</a>
<a href="/gene/5663/ortholog/">all</a>
</dd>
<dt style="padding-top:.5em;">
<span class="new-icon">NEW</span>
</dt>
<dd style="padding-top:.5em;">
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/5663/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
<br />
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/5663/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
</dd>
</dl>
</div>
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<div class="rprt-section gene-genomic-context">
<section class="rprt-section-header" id="genomic-context">
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<span class="ui-ncbitoggler-master-text">Genomic context</span>
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</h2>
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</section>
<div class="rprt-section-body">
<div class="gc_cont">
<div class="gt_cont_contents">
<div style="float:right"><span>See PSEN1 in </span><a href="/genome/gdv/?context=gene&amp;acc=5663" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="GCF_000001405.40">Genome Data Viewer</a> </div>
<dl class="dl-chr-info" style="float:left;margin-top:0;">
<dt>Location: </dt>
<dd>
<span style="display:inline-block;">14q24.2</span>
</dd>
</dl>
</div>
<dl class="dl-chr-info exon-count">
<dt>Exon count: </dt>
<dd>13</dd>
</dl>
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="">
<thead>
<tr>
<th style="max-width:15%">Annotation release</th>
<th style="max-width:10%">Status</th>
<th>Assembly</th>
<th>
<span title="Chromosome">Chr</span>
</th>
<th>Location</th>
</tr>
</thead>
<tbody>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=5663&amp;link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
<td>14</td>
<td>NC_000014.9 (73136417..73223691) </td>
</tr>
<tr>
<td>RS_2024_08</td>
<td>current</td>
<td>T2T-CHM13v2.0 (<a href="/assembly/GCF_009914755.1/" ref="ncbi_uid=5663&amp;link_uid=GCF_009914755.1">GCF_009914755.1</a>)</td>
<td>14</td>
<td>NC_060938.1 (67341963..67429152) </td>
</tr>
<tr>
<td>RS_2024_09</td>
<td>previous assembly</td>
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=5663&amp;link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
<td>14</td>
<td>NC_000014.8 (73603215..73690399) </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<p class="withnote margin_t2em"><strong>Chromosome 14 - NC_000014.9</strong><img usemap="#nbrMap5663_568815584" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=5663&amp;nuc_gi=568815584&amp;n0=RBM25-AS1&amp;n1=LOC126861995&amp;n2=RBM25&amp;n3=LOC127827927&amp;n4=LOC127827928&amp;n5=LOC100422493&amp;n6=LOC127827929&amp;n7=LOC130056042&amp;n8=PSEN1&amp;n9=LOC130056043&amp;n10=LOC130056044&amp;n11=LOC127827930&amp;n12=LOC127827931&amp;n13=LOC127827932&amp;n14=LOC127827933&amp;n15=LOC127827934&amp;n16=LOC127827935&amp;n17=LOC130056045&amp;n18=LOC125048438&amp;n19=PAPLN&amp;n20=LOC127827936&amp;n21=PAPLN-AS1&amp;n22=LOC130056046&amp;n23=RNU6-419P" /><map name="nbrMap5663_568815584" id="nbrMap5663_568815584">
<area shape="rect" onMouseOver="showtip(this,event,'MED14-independent group 3 enhancer GRCh37_chr14:73524555-73525754')" onMouseOut="hidetip()" coords="4,23,74,31" alt="Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:73524555-73525754" href="/gene/126861995" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr14:73531656-73532156')" onMouseOut="hidetip()" coords="15,35,85,43" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73531656-73532156" href="/gene/127827927" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr14:73532157-73532657')" onMouseOut="hidetip()" coords="16,47,86,55" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73532157-73532657" href="/gene/127827928" />
<area shape="rect" onMouseOver="showtip(this,event,'RBM25 antisense RNA 1')" onMouseOut="hidetip()" coords="17,59,72,67" alt="Neighboring gene RBM25 antisense RNA 1" href="/gene/105370560" />
<area shape="rect" onMouseOver="showtip(this,event,'required for meiotic nuclear division 1 homolog (S. cerevisiae) pseudogene')" onMouseOut="hidetip()" coords="21,71,91,79" alt="Neighboring gene required for meiotic nuclear division 1 homolog (S. cerevisiae) pseudogene" href="/gene/100422493" />
<area shape="rect" onMouseOver="showtip(this,event,'RNA binding motif protein 25')" onMouseOut="hidetip()" coords="40,83,175,91" alt="Neighboring gene RNA binding motif protein 25" href="/gene/58517" />
<area shape="rect" onMouseOver="showtip(this,event,'OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:73591861-73592400')" onMouseOut="hidetip()" coords="115,23,185,31" alt="Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:73591861-73592400" href="/gene/127827929" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 5904')" onMouseOut="hidetip()" coords="133,35,203,43" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5904" href="/gene/130056042" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 5905')" onMouseOut="hidetip()" coords="134,47,204,55" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5905" href="/gene/130056043" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 8694')" onMouseOut="hidetip()" coords="134,59,204,67" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8694" href="/gene/130056044" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr14:73635088-73636024')" onMouseOut="hidetip()" coords="186,23,256,31" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73635088-73636024" href="/gene/127827930" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancer GRCh37_chr14:73636025-73636961')" onMouseOut="hidetip()" coords="187,83,257,91" alt="Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73636025-73636961" href="/gene/127827931" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG hESC enhancer GRCh37_chr14:73637234-73637812')" onMouseOut="hidetip()" coords="189,95,259,103" alt="Neighboring gene NANOG hESC enhancer GRCh37_chr14:73637234-73637812" href="/gene/127827932" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:73651850-73652468')" onMouseOut="hidetip()" coords="214,35,284,43" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:73651850-73652468" href="/gene/127827933" />
<area shape="rect" onMouseOver="showtip(this,event,'NANOG hESC enhancer GRCh37_chr14:73689643-73690155')" onMouseOut="hidetip()" coords="276,23,346,31" alt="Neighboring gene NANOG hESC enhancer GRCh37_chr14:73689643-73690155" href="/gene/127827934" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:73693769-73694664')" onMouseOut="hidetip()" coords="283,47,353,55" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:73693769-73694664" href="/gene/127827935" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 8695')" onMouseOut="hidetip()" coords="291,35,361,43" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8695" href="/gene/130056045" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K4me1 hESC enhancers GRCh37_chr14:73702487-73703059 and GRCh37_chr14:73703060-73703631')" onMouseOut="hidetip()" coords="297,59,367,67" alt="Neighboring gene H3K4me1 hESC enhancers GRCh37_chr14:73702487-73703059 and GRCh37_chr14:73703060-73703631" href="/gene/125048438" />
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:73704205-73704775')" onMouseOut="hidetip()" coords="300,83,370,91" alt="Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:73704205-73704775" href="/gene/127827936" />
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 5906')" onMouseOut="hidetip()" coords="314,95,384,103" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5906" href="/gene/130056046" />
<area shape="rect" onMouseOver="showtip(this,event,'PAPLN antisense RNA 1')" onMouseOut="hidetip()" coords="326,107,381,115" alt="Neighboring gene PAPLN antisense RNA 1" href="/gene/101928123" />
<area shape="rect" onMouseOver="showtip(this,event,'RNA, U6 small nuclear 419, pseudogene')" onMouseOut="hidetip()" coords="330,119,385,127" alt="Neighboring gene RNA, U6 small nuclear 419, pseudogene" href="/gene/106479751" />
<area shape="rect" onMouseOver="showtip(this,event,'papilin, proteoglycan like sulfated glycoprotein')" onMouseOut="hidetip()" coords="332,131,423,139" alt="Neighboring gene papilin, proteoglycan like sulfated glycoprotein" href="/gene/89932" />
</map>
</p>
</div>
</div>
<div class="rprt-section gene-genomic-regions-transcripts-products">
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
<h2 id="header-genomic-regions-transcripts-products">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Genomic_Regions_Transcripts_a" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
</div>
<div>
<p class="choose">
<label for="accession" class="label">Genomic Sequence: </label>
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="9606" data-geneid="5663">
<option value="NC_000014.9_73136416_73223690">NC_000014.9 Chromosome 14 Reference GRCh38.p14 Primary Assembly</option>
<option value="NG_007386.2_5036_92220">NG_007386.2 RefSeqGene</option>
<option value="NC_060938.1_67341962_67429151">NC_060938.1 Chromosome 14 Alternate T2T-CHM13v2.0</option>
<option value="NC_000014.8_73603214_73690398">NC_000014.8 Chromosome 14 Reference GRCh37.p13 Primary Assembly</option>
</select>
</p>
</div>
<div id="NC_000014" class="divAccession">
<div class="seq-viewer">
<p class="note-link">
<strong>Go to nucleotide:</strong>
<a title="Nucleotide Graphic report" href="/nuccore/NC_000014.9?report=graph&amp;from=73123325&amp;to=73236781&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=NC_000014.9">Graphics</a>
<a title="Nucleotide FASTA report" href="/nuccore/NC_000014.9?report=fasta&amp;from=73136417&amp;to=73223691" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=NC_000014.9">FASTA</a>
<a title="Nucleotide GenBank report" href="/nuccore/NC_000014.9?report=genbank&amp;from=73136417&amp;to=73223691" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=NC_000014.9">GenBank</a>
</p>
<div id="divNC_000014" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000014.9&amp;from=73123325&amp;to=73236781&amp;app_context=Gene&amp;assm_context=GCF_000001405.40">
<a href="?appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000014.9&amp;from=73123325&amp;to=73236781&amp;app_context=Gene&amp;assm_context=GCF_000001405.40"></a>
</div>
</div>
</div>
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000014.9" sid="1" type="hidden" id="nucleotideLink_NC_000014_9_73136416_73223690" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000014.9?report=graph&amp;amp;from=73123325&amp;amp;to=73236781&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=5663&amp;amp;link_uid=NC_000014.9&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000014.9?report=fasta&amp;amp;from=73136417&amp;amp;to=73223691&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=5663&amp;amp;link_uid=NC_000014.9&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000014.9?report=genbank&amp;amp;from=73136417&amp;amp;to=73223691&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=5663&amp;amp;link_uid=NC_000014.9&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000014.9" sid="1" type="hidden" id="relString_NC_000014_9_73136416_73223690" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000014.9&amp;amp;from=73123325&amp;amp;to=73236781&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.40" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NG_007386.2" sid="1" type="hidden" id="nucleotideLink_NG_007386_2_5036_92220" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NG_007386.2?report=graph&amp;amp;from=1&amp;amp;to=105298&amp;amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:ShowAllButGenes,SNPs:false,CDSProductFeats:false,ShowLabelsForAllFeatures:true,HighlightMode:2][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results][key:alignment_track,category:Alignments,annots:Unnamed][key:alignment_track,category:Alignments,annots:NA000079160.1][key:alignment_track,category:Alignments,annots:NA000010065.1]&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=5663&amp;amp;link_uid=NG_007386.2&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NG_007386.2?report=fasta&amp;amp;from=5037&amp;amp;to=92221&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=5663&amp;amp;link_uid=NG_007386.2&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NG_007386.2?report=genbank&amp;amp;from=5037&amp;amp;to=92221&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=5663&amp;amp;link_uid=NG_007386.2&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NG_007386.2" sid="1" type="hidden" id="relString_NG_007386_2_5036_92220" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NG_007386.2&amp;amp;from=1&amp;amp;to=105298&amp;amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:ShowAllButGenes,SNPs:false,CDSProductFeats:false,ShowLabelsForAllFeatures:true,HighlightMode:2][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results][key:alignment_track,category:Alignments,annots:Unnamed][key:alignment_track,category:Alignments,annots:NA000079160.1][key:alignment_track,category:Alignments,annots:NA000010065.1]" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_060938.1" sid="1" type="hidden" id="nucleotideLink_NC_060938_1_67341962_67429151" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_060938.1?report=graph&amp;amp;from=67328884&amp;amp;to=67442229&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_009914755.1&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=5663&amp;amp;link_uid=NC_060938.1&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_060938.1?report=fasta&amp;amp;from=67341963&amp;amp;to=67429152&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=5663&amp;amp;link_uid=NC_060938.1&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_060938.1?report=genbank&amp;amp;from=67341963&amp;amp;to=67429152&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=5663&amp;amp;link_uid=NC_060938.1&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_060938.1" sid="1" type="hidden" id="relString_NC_060938_1_67341962_67429151" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_060938.1&amp;amp;from=67328884&amp;amp;to=67442229&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_009914755.1" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000014.8" sid="1" type="hidden" id="nucleotideLink_NC_000014_8_73603214_73690398" value="&lt;p class=&quot;note-link&quot;&gt;&lt;strong&gt;Go to nucleotide:&lt;/strong&gt;&lt;a title=&quot;Nucleotide Graphic report&quot; href=&quot;/nuccore/NC_000014.8?report=graph&amp;amp;from=73590136&amp;amp;to=73703476&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=5663&amp;amp;link_uid=NC_000014.8&quot;&gt;Graphics&lt;/a&gt;&lt;a title=&quot;Nucleotide FASTA report&quot; href=&quot;/nuccore/NC_000014.8?report=fasta&amp;amp;from=73603215&amp;amp;to=73690399&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=5663&amp;amp;link_uid=NC_000014.8&quot;&gt;FASTA&lt;/a&gt;&lt;a title=&quot;Nucleotide GenBank report&quot; href=&quot;/nuccore/NC_000014.8?report=genbank&amp;amp;from=73603215&amp;amp;to=73690399&quot; ref=&quot;ordinalpos=1&amp;amp;ncbi_uid=5663&amp;amp;link_uid=NC_000014.8&quot;&gt;GenBank&lt;/a&gt;&lt;/p&gt;" />
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000014.8" sid="1" type="hidden" id="relString_NC_000014_8_73603214_73690398" value="appname=ncbigene&amp;amp;embedded=true&amp;amp;noslider=1&amp;amp;id=NC_000014.8&amp;amp;from=73590136&amp;amp;to=73703476&amp;amp;app_context=Gene&amp;amp;assm_context=GCF_000001405.25" />
</div>
</div>
<div class="rprt-section gene-gene-expression">
<section class="rprt-section-header" id="gene-expression">
<h2 id="header-gene-expression">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-gene-expression .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Expression</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Expression" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<div style="text-align:right;">
<a href="/gene/5663/?report=expression" data-url="/gene/5663/?report=expression" id="gene-expression-see-details">See details</a>
</div>
<div id="gene-expression-app" data-url="https://www.ncbi.nlm.nih.gov/gene/5663" data-report-type="summary">
<div>
<script type="text/javascript">
window.tissues_data = {'adrenal 10wk': {'id': '5663_Adrenal_10wk_PRJNA270632', 'gene': 5663, 'source_name': 'adrenal 10wk', 'full_rpkm': 6.00684, 'exp_rpkm': 6.01, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734401617821729}, 'adrenal 16wk': {'id': '5663_Adrenal_16wk_PRJNA270632', 'gene': 5663, 'source_name': 'adrenal 16wk', 'full_rpkm': 5.35515, 'exp_rpkm': 5.36, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734401617821730}, 'adrenal 18wk': {'id': '5663_Adrenal_18wk_PRJNA270632', 'gene': 5663, 'source_name': 'adrenal 18wk', 'full_rpkm': 7.60065, 'exp_rpkm': 7.6, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734401617821731}, 'adrenal 20wk': {'id': '5663_Adrenal_20wk_PRJNA270632', 'gene': 5663, 'source_name': 'adrenal 20wk', 'full_rpkm': 7.61222, 'exp_rpkm': 7.61, 'var': 1.105888, 'project_desc': 'PRJNA270632', '_version_': 1785734401617821732}, 'heart 10wk': {'id': '5663_Heart_10wk;_PRJNA270632', 'gene': 5663, 'source_name': 'heart 10wk', 'full_rpkm': 4.38996, 'exp_rpkm': 4.39, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734401617821733}, 'heart 11wk': {'id': '5663_Heart_11wk;_PRJNA270632', 'gene': 5663, 'source_name': 'heart 11wk', 'full_rpkm': 2.91812, 'exp_rpkm': 2.92, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734401617821734}, 'heart 17wk': {'id': '5663_Heart_17wk;_PRJNA270632', 'gene': 5663, 'source_name': 'heart 17wk', 'full_rpkm': 2.93059, 'exp_rpkm': 2.93, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734401617821735}, 'heart 18wk': {'id': '5663_Heart_18wk;_PRJNA270632', 'gene': 5663, 'source_name': 'heart 18wk', 'full_rpkm': 3.12843, 'exp_rpkm': 3.13, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734401617821736}, 'heart 20wk': {'id': '5663_Heart_20wk_PRJNA270632', 'gene': 5663, 'source_name': 'heart 20wk', 'full_rpkm': 3.0399, 'exp_rpkm': 3.04, 'var': 1.041918, 'project_desc': 'PRJNA270632', '_version_': 1785734401617821737}, 'intestine 10wk': {'id': '5663_Intestine_10wk_PRJNA270632', 'gene': 5663, 'source_name': 'intestine 10wk', 'full_rpkm': 2.90185, 'exp_rpkm': 2.9, 'var': 0.1681902, 'project_desc': 'PRJNA270632', '_version_': 1785734401617821738}, 'intestine 11wk': {'id': '5663_Intestine_11wk_PRJNA270632', 'gene': 5663, 'source_name': 'intestine 11wk', 'full_rpkm': 3.09904, 'exp_rpkm': 3.1, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734401617821739}, 'intestine 15wk': {'id': '5663_Intestine_15wk_PRJNA270632', 'gene': 5663, 'source_name': 'intestine 15wk', 'full_rpkm': 7.85086, 'exp_rpkm': 7.85, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734401618870272}, 'intestine 17wk': {'id': '5663_Intestine_17wk_PRJNA270632', 'gene': 5663, 'source_name': 'intestine 17wk', 'full_rpkm': 3.1486, 'exp_rpkm': 3.15, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734401618870273}, 'intestine 20wk': {'id': '5663_Intestine_20wk_PRJNA270632', 'gene': 5663, 'source_name': 'intestine 20wk', 'full_rpkm': 13.6973, 'exp_rpkm': 13.7, 'var': 2.14144, 'project_desc': 'PRJNA270632', '_version_': 1785734401618870274}, 'kidney 10wk': {'id': '5663_Kidney_10wk_PRJNA270632', 'gene': 5663, 'source_name': 'kidney 10wk', 'full_rpkm': 3.56532, 'exp_rpkm': 3.57, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734401618870275}, 'kidney 16wk': {'id': '5663_Kidney_16wk_PRJNA270632', 'gene': 5663, 'source_name': 'kidney 16wk', 'full_rpkm': 2.17042, 'exp_rpkm': 2.17, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734401618870276}, 'kidney 20wk': {'id': '5663_Kidney_20wk_PRJNA270632', 'gene': 5663, 'source_name': 'kidney 20wk', 'full_rpkm': 1.21671, 'exp_rpkm': 1.22, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734401618870277}, 'lung 10wk': {'id': '5663_Lung_10wk_PRJNA270632', 'gene': 5663, 'source_name': 'lung 10wk', 'full_rpkm': 3.90635, 'exp_rpkm': 3.91, 'var': 0.0899388, 'project_desc': 'PRJNA270632', '_version_': 1785734401618870278}, 'lung 17wk': {'id': '5663_Lung_17wk_PRJNA270632', 'gene': 5663, 'source_name': 'lung 17wk', 'full_rpkm': 5.00272, 'exp_rpkm': 5.0, 'var': 0.020729, 'project_desc': 'PRJNA270632', '_version_': 1785734401618870279}, 'lung 20wk': {'id': '5663_Lung_20wk_PRJNA270632', 'gene': 5663, 'source_name': 'lung 20wk', 'full_rpkm': 4.7266, 'exp_rpkm': 4.73, 'var': 1.73066, 'project_desc': 'PRJNA270632', '_version_': 1785734401618870280}, 'stomach 10wk': {'id': '5663_Stomach_10wk_PRJNA270632', 'gene': 5663, 'source_name': 'stomach 10wk', 'full_rpkm': 3.01013, 'exp_rpkm': 3.01, 'var': 0.0236786, 'project_desc': 'PRJNA270632', '_version_': 1785734401618870281}, 'stomach 16wk': {'id': '5663_Stomach_16wk_PRJNA270632', 'gene': 5663, 'source_name': 'stomach 16wk', 'full_rpkm': 4.9834, 'exp_rpkm': 4.98, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734401618870282}, 'stomach 18wk': {'id': '5663_Stomach_18wk_PRJNA270632', 'gene': 5663, 'source_name': 'stomach 18wk', 'full_rpkm': 5.64186, 'exp_rpkm': 5.64, 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<select name="p" id="project-selector">
<option value="SRP051249" selected="selected" data-bioproject="PRJNA270632">
Tissue-specific circular RNA induction during human fetal development
</option>
<option value="SRP056969" data-bioproject="PRJNA280600">
RNA sequencing of total RNA from 20 human tissues
</option>
<option value="ERP003613" data-bioproject="PRJEB4337">
HPA RNA-seq normal tissues
</option>
</select>
<ul id="project-summary">
<li id="project-summary-title">Project title:
Tissue-specific circular RNA induction during human fetal development
</li>
<li id="project-summary-desc">Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA</li>
<li id="project-summary-bioprojects">BioProject: <a href="/bioproject/PRJNA270632/">PRJNA270632</a>
</li>
<li id="project-summary-pubs">Publication:
<span><a href="/pubmed/26076956/">PMID 26076956</a></span>
</li>
<li id="project-summary-analysis-date">Analysis date: Mon Apr 2 22:54:59 2018</li>
</ul>
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</div>
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<section class="rprt-section-header" id="bibliography"><h2 id="header-bibliography"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-bibliography .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Bibliography</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Bibliography" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
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<div class="generif-pubmed">
<h3 id="relatedarticlesinpubmed">
<a href="#" class="jig-ncbitoggler-open">Related articles in PubMed</a>
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<ol class="generef-link">
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<a href="/pubmed/19667325/" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=19667325">Presenilin1 G217R mutation linked to Alzheimer disease with cotton wool plaques.</a>
<span class="pubmed-auth-date"> Norton JB, <em>et al</em>. Neurology, 2009 Aug 11. PMID 19667325, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC2727146/" ref="ordinalpos=0&amp;ncbi_uid=5663&amp;link_uid=PMC2727146">Free PMC Article</a></span></span>
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<a href="/pubmed/18445230/" ref="ordinalpos=2&amp;ncbi_uid=5663&amp;link_uid=18445230">Down-regulation of insulin-degrading enzyme by presenilin 1 V97L mutant potentially underlies increased levels of amyloid beta 42.</a>
<span class="pubmed-auth-date"> Qin W, <em>et al</em>. Eur J Neurosci, 2008 May. PMID 18445230</span>
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<a href="/pubmed/18479822/" ref="ordinalpos=3&amp;ncbi_uid=5663&amp;link_uid=18479822">Novel presenilin 1 variant (P117A) causing Alzheimer's disease in the fourth decade of life.</a>
<span class="pubmed-auth-date"> Kauwe JS, <em>et al</em>. Neurosci Lett, 2008 Jun 20. PMID 18479822, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC2838423/" ref="ordinalpos=0&amp;ncbi_uid=5663&amp;link_uid=PMC2838423">Free PMC Article</a></span></span>
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<span class="pubmed-auth-date"> Batelli S, <em>et al</em>. Alzheimer Dis Assoc Disord, 2008 Apr-Jun. PMID 18525293</span>
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<span class="pubmed-auth-date"> Cheung KH, <em>et al</em>. Neuron, 2008 Jun 26. PMID 18579078, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC2495086/" ref="ordinalpos=0&amp;ncbi_uid=5663&amp;link_uid=PMC2495086">Free PMC Article</a></span></span>
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</ol>
<p class="see-all-pm">
<a href="/pubmed?LinkName=gene_pubmed&amp;from_uid=5663" title="See all 877 citations in Pubmed">See all (877) citations in PubMed</a>
</p>
</div>
</div>
<div class="generif-pubmed generif">
<h3 id="generifsgenereferencesintofunctions">
<a href="#" class="jig-ncbitoggler-open">GeneRIFs: Gene References Into Functions</a>
</h3>
<div>
<a href="/gene/about-generif" class="whatisthis">What's a GeneRIF?</a>
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</li>
<li class="gene-rif-popper">
<a href="/pubmed/38824433" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=38824433">The presenilin 1 mutation P436S causes familial Alzheimer's disease with elevated Abeta43 and atypical clinical manifestations.</a>
<div id="gene-popper5" class="gene-rif-popper">Title: The presenilin 1 mutation P436S causes familial Alzheimer's disease with elevated Aβ43 and atypical clinical manifestations.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38851626" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=38851626">Presenilin-1 DeltaE9 mutation associated sarcoplasmic reticulum leak alters [Ca[2+]]i distribution in human iPSC-derived cardiomyocytes.</a>
<div id="gene-popper6" class="gene-rif-popper">Title: Presenilin-1 ΔE9 mutation associated sarcoplasmic reticulum leak alters [Ca(2+)](i) distribution in human iPSC-derived cardiomyocytes.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38227890" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=38227890">Presenilin Gene Mutation-associated Psychosis: Phenotypic Characteristics and Clinical Implications.</a>
<div id="gene-popper7" class="gene-rif-popper">Title: Presenilin Gene Mutation-associated Psychosis: Phenotypic Characteristics and Clinical Implications.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38380882" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=38380882">Presenilin-1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage.</a>
<div id="gene-popper8" class="gene-rif-popper">Title: Presenilin-1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/37864790" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=37864790">Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development.</a>
<div id="gene-popper9" class="gene-rif-popper">Title: Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development.</div>
</li>
<li class="gene-rif-popper">
<a href="/pubmed/38215435" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=38215435">Neuropathology of patients with preclinical or early clinical Alzheimer's disease with pathogenic PSEN1_p. L392V: Comparison of advanced siblings.</a>
<div id="gene-popper10" class="gene-rif-popper">Title: Neuropathology of patients with preclinical or early clinical Alzheimer's disease with pathogenic PSEN1_p. L392V: Comparison of advanced siblings.</div>
</li>
</ol>
</div>
<div class="submit-genrif">
<span>Submit:</span>
<a href="/gene/submit-generif/?geneId=5663&amp;sym=PSEN1&amp;name=presenilin 1&amp;org=Homo sapiens">New GeneRIF</a>
<a href="/RefSeq/update.cgi?geneid=5663&amp;symbol=PSEN1;task=fixpub">Correction</a>
<a href="https://www.ncbi.nlm.nih.gov/gene?db=gene&amp;report=generif&amp;term=5663" class="seeall-generif">See all GeneRIFs (622)</a>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-phenotypes">
<section class="rprt-section-header" id="phenotypes">
<h2 id="header-phenotypes">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-phenotypes .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Phenotypes</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Phenotype" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body info-phenotype">
<p class="nochild-link">
<a href="/gtr/tests/?term=PSEN1[gene]">Find tests for this gene in the NIH Genetic Testing Registry (GTR)</a>
</p>
<p class="nochild-link">
<a href="/gap/PheGenI?tab=1&amp;gene=5663">Review eQTL and phenotype association data in this region using PheGenI</a>
</p>
<div>
<h3 id="associatedconditions">Associated conditions</h3>
<table class="jig-ncbigrid gtr-associated-cond">
<thead>
<tr>
<th class="description">Description</th>
<th>Tests</th>
</tr>
</thead>
<tbody>
<tr>
<td>
<a href="/gtr/conditions/C3151038" ref="ncbi_uid=5663&amp;link_uid=C3151038">Acne inversa, familial, 3</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C3151038" ref="ncbi_uid=5663&amp;link_uid=C3151038">C3151038</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/613737" ref="ncbi_uid=5663"> 613737</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
</div>
</td>
<td>
<a href="/gtr/tests/?term=C3151038[DISCUI]&amp;condition=C3151038&amp;compare_labs=1" ref="ncbi_uid=5663">Compare labs</a>
</td>
</tr>
<tr>
<td>
<a href="/gtr/conditions/C1843013" ref="ncbi_uid=5663&amp;link_uid=C1843013">Alzheimer disease 3</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C1843013" ref="ncbi_uid=5663&amp;link_uid=C1843013">C1843013</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/607822" ref="ncbi_uid=5663"> 607822</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <a href="/books/NBK1161" ref="ncbi_uid=5663">Alzheimer Disease Overview</a></span>
</div>
</td>
<td>
<a href="/gtr/tests/?term=C1843013[DISCUI]&amp;condition=C1843013&amp;compare_labs=1" ref="ncbi_uid=5663">Compare labs</a>
</td>
</tr>
<tr>
<td>
<a href="/gtr/conditions/C3160720" ref="ncbi_uid=5663&amp;link_uid=C3160720">Dilated cardiomyopathy 1U</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C3160720" ref="ncbi_uid=5663&amp;link_uid=C3160720">C3160720</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/613694" ref="ncbi_uid=5663"> 613694</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <a href="/books/NBK1309" ref="ncbi_uid=5663">Dilated Cardiomyopathy Overview</a></span>
</div>
</td>
<td>
<a href="/gtr/tests/?term=C3160720[DISCUI]&amp;condition=C3160720&amp;compare_labs=1" ref="ncbi_uid=5663">Compare labs</a>
</td>
</tr>
<tr>
<td>
<a href="/gtr/conditions/C0338451" ref="ncbi_uid=5663&amp;link_uid=C0338451">Frontotemporal dementia</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C0338451" ref="ncbi_uid=5663&amp;link_uid=C0338451">C0338451</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/600274" ref="ncbi_uid=5663"> 600274</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
</div>
</td>
<td>
<a href="/gtr/tests/?term=C0338451[DISCUI]&amp;condition=C0338451&amp;compare_labs=1" ref="ncbi_uid=5663">Compare labs</a>
</td>
</tr>
<tr>
<td>
<a href="/gtr/conditions/C0236642" ref="ncbi_uid=5663&amp;link_uid=C0236642">Pick disease</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C0236642" ref="ncbi_uid=5663&amp;link_uid=C0236642">C0236642</a></span>
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/172700" ref="ncbi_uid=5663"> 172700</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
</div>
</td>
<td>
<a href="/gtr/tests/?term=C0236642[DISCUI]&amp;condition=C0236642&amp;compare_labs=1" ref="ncbi_uid=5663">Compare labs</a>
</td>
</tr>
<tr>
<td>
<a href="/gtr/conditions/C0007193" ref="ncbi_uid=5663&amp;link_uid=C0007193">Primary dilated cardiomyopathy</a>
<div class="gtr-associated-cond-extra">
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C0007193" ref="ncbi_uid=5663&amp;link_uid=C0007193">C0007193</a></span>
<span class="gtr-associated-cond-extra-i">GeneReviews: <a href="/books/NBK1309" ref="ncbi_uid=5663">Dilated Cardiomyopathy Overview</a></span>
</div>
</td>
<td>
<a href="/gtr/tests/?term=C0007193[DISCUI]&amp;condition=C0007193&amp;compare_labs=1" ref="ncbi_uid=5663">Compare labs</a>
</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-variation">
<section class="rprt-section-header" id="variation">
<h2 id="header-variation">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Variation</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p class="nochild-link">
<a href="/clinvar/?term=PSEN1[gene]" ref="log$=recordlinks">See variants in ClinVar</a>
</p>
<p class="nochild-link">
<a href="/dbvar?LinkName=gene_dbvar&amp;from_uid=5663" ref="log$=recordlinks">See studies and variants in dbVar</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=5663[geneid]&amp;assm=GCF_000001405.25" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh37.p13)">See Variation Viewer (GRCh37.p13)</a>
</p>
<p class="nochild-link">
<a href="/variation/view/?q=5663[geneid]" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh38)">See Variation Viewer (GRCh38)</a>
</p>
<set></set>
<set></set>
</div>
</div>
<div class="rprt-section gene-pathways">
<section class="rprt-section-header" id="pathways">
<h2 id="header-pathways">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-pathways .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Pathways from PubChem</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<ul class="geneinfo-subsec infopathway">
<iframe title="Pathways in which the gene target is involved" class="pubchem-widget" scrolling="no" src="https://pubchem.ncbi.nlm.nih.gov/gene/5663#section=Pathways&amp;embed=true&amp;hide_all_headings=true&amp;page_size=25" style="border: 0; width: 100%;"></iframe>
<script type="text/javascript" src="https://pubchem.ncbi.nlm.nih.gov/pcfe/libs/iframeResizer.min.js"></script>
<script type="text/javascript">iFrameResize({log: false, checkOrigin: false}, '.pubchem-widget')</script>
</ul>
</div>
</div>
<div class="rprt-section gene-interactions">
<section class="rprt-section-header" id="interactions">
<h2 id="header-interactions">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-interactions .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Interactions</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Interactions" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<table summary="Gene Interaction" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/5663/data/interaction/',webserviceParams: 'p$l=Ajax&amp;p$debugoutput=off', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th id="inter-prod">Products</th>
<th id="inter-interactant">Interactant</th>
<th id="inter-otherGene">Other Gene</th>
<th id="inter-compl">Complex</th>
<th id="inter-source">Source</th>
<th id="inter-pubs">Pubs</th>
<th id="inter-desc">Description</th>
</tr>
</thead>
<tbody></tbody>
</table>
</div>
</div>
<div class="rprt-section gene-general-gene-info">
<section class="rprt-section-header" id="general-gene-info">
<h2 id="header-general-gene-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General gene information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body" style="">
<div id="gene-markers">
<h3 id="markers">
<a class="jig-ncbitoggler">Markers</a>
</h3>
<div>
<ul class="marker odd">
<li class="marker">D14S1264 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=154642%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=154642">UniSTS:154642</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">G38182 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=61209%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=61209">UniSTS:61209</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">SHGC-132632 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=185371%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=185371">UniSTS:185371</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">G38198 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=37423%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=37423">UniSTS:37423</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">WI-11404 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=44594%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=44594">UniSTS:44594</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">RH77790 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=58424%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=58424">UniSTS:58424</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">D14S43 (e-PCR), detects polymorphism<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=72766%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=72766">UniSTS:72766</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">SGC34362 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=58943%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=58943">UniSTS:58943</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">G38133 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=57156%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=57156">UniSTS:57156</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">G35565 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=25416%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=25416">UniSTS:25416</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">G38272 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=61768%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=61768">UniSTS:61768</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">G38175 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=73545%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=73545">UniSTS:73545</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">G38218 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=5967%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=5967">UniSTS:5967</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">SHGC-78932 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=95823%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=95823">UniSTS:95823</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">G35501 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=42580%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=42580">UniSTS:42580</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">G38323 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=59480%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=59480">UniSTS:59480</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">G38215 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=77408%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=77408">UniSTS:77408</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">G38068 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=79456%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=79456">UniSTS:79456</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">G35665 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=38760%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=38760">UniSTS:38760</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">PSEN1_232 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=277618%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=277618">UniSTS:277618</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">D15S1477 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=474482%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=474482">UniSTS:474482</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">SHGC-31609 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=35446%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=35446">UniSTS:35446</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">G38324 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=42359%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=42359">UniSTS:42359</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">G38176 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=48247%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=48247">UniSTS:48247</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">D14S1438 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=153981%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=153981">UniSTS:153981</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">D14S1439 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=153982%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=153982">UniSTS:153982</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">D14S1440 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=153983%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=153983">UniSTS:153983</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">D14S1442 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=153985%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=153985">UniSTS:153985</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">G38129 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=41366%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=41366">UniSTS:41366</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">A005E05 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=57512%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=57512">UniSTS:57512</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">G38136 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=3507%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=3507">UniSTS:3507</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">SHGC-36769 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=18869%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=18869">UniSTS:18869</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">G38220 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=9152%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=9152">UniSTS:9152</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">G38203 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=67017%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=67017">UniSTS:67017</a></li></ul></li>
</ul>
<ul class="marker odd">
<li class="marker">G38066 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=11726%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=11726">UniSTS:11726</a></li></ul></li>
</ul>
<ul class="marker ">
<li class="marker">G38184 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=65743%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=65743">UniSTS:65743</a></li></ul></li>
</ul>
</div>
</div>
<div></div>
<div class="infosec">
<h3 id="homology">
<a class="jig-ncbitoggler-open">Homology</a>
</h3>
<ul class="geneinfo-subsec">
<li>
<a href="/gene/5663/ortholog/" id="ncbi-ortholog-link">NCBI Orthologs</a>
</li>
<a href="https://www.orthodb.org/?ncbi=5663" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178" target="_blank">
Orthologs from OrthoDB
</a>
</ul>
</div>
<!--<component id="Gene_InfoPathway"/>-->
<div class="gene-ontology infosec">
<h3 id="gene-ontology">
<a class="jig-ncbitoggler-open">
<span>Gene Ontology</span>
</a>
<a target="_blank" href="http://www.ebi.ac.uk/GOA" class="g-ontology-src" title="Provided by GOA">Provided by GOA</a>
</h3>
<div class="ontology-tables">
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Function</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051117">enables ATPase binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-1-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/26094765" target="_blank" title="PubMed ID 26094765" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=26094765">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030165">enables PDZ domain binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-2-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/10551805" target="_blank" title="PubMed ID 10551805" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=10551805">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042500">enables aspartic endopeptidase activity, intramembrane cleaving</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-3-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042500">enables aspartic endopeptidase activity, intramembrane cleaving</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-4-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/26280335" target="_blank" title="PubMed ID 26280335" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=26280335">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042500">enables aspartic endopeptidase activity, intramembrane cleaving</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-5-0" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/17428795" target="_blank" title="PubMed ID 17428795" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=17428795">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0004190">enables aspartic-type endopeptidase activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
<div id="evidence-code-6-0" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/24217950" target="_blank" title="PubMed ID 24217950" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=24217950">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0008013">enables beta-catenin binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-7-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/9632714" target="_blank" title="PubMed ID 9632714" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=9632714">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045296">enables cadherin binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-8-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005262">enables calcium channel activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-9-0" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/16959576" target="_blank" title="PubMed ID 16959576" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=16959576">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0004175">enables endopeptidase activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-10-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/8755489" target="_blank" title="PubMed ID 8755489" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=8755489">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0004175">enables endopeptidase activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-11-0" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/12763021" target="_blank" title="PubMed ID 12763021" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=12763021">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0004175">enables endopeptidase activity</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-12-0" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/12297508" target="_blank" title="PubMed ID 12297508" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=12297508">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0070851">enables growth factor receptor binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-13-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/26094765" target="_blank" title="PubMed ID 26094765" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=26094765">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-func">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005515">enables protein binding</a>
</td>
<td headers="ont-evi- ont-evi-code-">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
<div id="evidence-code-14-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi- ont-pub-"><a href="/pubmed/9223340,9689133,10508860,11076969,11083918,12297508,12522139,12901838,15322109,15890777,16007100,16641999,18201567,21115843,21143716,21163940,22036569,25394380,25959826,26094765,26280335,29611543,30559186,32296183,32814053" target="_blank" title="PubMed ID 9223340,9689133,10508860,11076969,11083918,12297508,12522139,12901838,15322109,15890777,16007100,16641999,18201567,21115843,21143716,21163940,22036569,25394380,25959826,26094765,26280335,29611543,30559186,32296183,32814053" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=9223340,9689133,10508860,11076969,11083918,12297508,12522139,12901838,15322109,15890777,16007100,16641999,18201567,21115843,21143716,21163940,22036569,25394380,25959826,26094765,26280335,29611543,30559186,32296183,32814053">PubMed</a> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Process</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0021870">involved_in Cajal-Retzius cell differentiation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-1-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006974">involved_in DNA damage response</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-2-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/25542424" target="_blank" title="PubMed ID 25542424" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=25542424">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0098712">involved_in L-glutamate import across plasma membrane</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-3-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0007220">involved_in Notch receptor processing</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-4-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/27608597" target="_blank" title="PubMed ID 27608597" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=27608597">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0007220">involved_in Notch receptor processing</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-5-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/15274632" target="_blank" title="PubMed ID 15274632" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=15274632">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0007219">involved_in Notch signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-6-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0002286">involved_in T cell activation involved in immune response</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-7-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0050852">involved_in T cell receptor signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-8-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042987">involved_in amyloid precursor protein catabolic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-9-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/27608597" target="_blank" title="PubMed ID 27608597" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=27608597">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042987">involved_in amyloid precursor protein catabolic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-10-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/12763021" target="_blank" title="PubMed ID 12763021" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=12763021">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042987">involved_in amyloid precursor protein catabolic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-11-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/12297508" target="_blank" title="PubMed ID 12297508" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=12297508">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042987">involved_in amyloid precursor protein catabolic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-12-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/15274632" target="_blank" title="PubMed ID 15274632" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=15274632">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042982">involved_in amyloid precursor protein metabolic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-13-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/26280335" target="_blank" title="PubMed ID 26280335" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=26280335">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0034205">involved_in amyloid-beta formation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-14-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0034205">involved_in amyloid-beta formation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-15-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-15-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/27608597" target="_blank" title="PubMed ID 27608597" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=27608597">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0034205">involved_in amyloid-beta formation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-16-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-16-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/12763021" target="_blank" title="PubMed ID 12763021" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=12763021">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0034205">involved_in amyloid-beta formation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-17-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-17-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/12297508,26280335" target="_blank" title="PubMed ID 12297508,26280335" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=12297508,26280335">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0097190">involved_in apoptotic signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-18-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-18-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0048143">involved_in astrocyte activation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-19-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-19-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20445063" target="_blank" title="PubMed ID 20445063" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=20445063">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0002265">involved_in astrocyte activation involved in immune response</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-20-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-20-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/23152628" target="_blank" title="PubMed ID 23152628" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=23152628">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0000045">involved_in autophagosome assembly</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-21-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-21-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0001568">involved_in blood vessel development</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-22-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-22-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0048854">involved_in brain morphogenesis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-23-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-23-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0055074">involved_in calcium ion homeostasis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-24-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-24-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0070588">involved_in calcium ion transmembrane transport</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-25-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-25-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0001708">involved_in cell fate specification</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-26-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-26-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0098609">acts_upstream_of_or_within cell-cell adhesion</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-27-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-27-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/11953314" target="_blank" title="PubMed ID 11953314" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=11953314">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1904646">involved_in cellular response to amyloid-beta</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-28-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-28-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/23152628" target="_blank" title="PubMed ID 23152628" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=23152628">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0021549">involved_in cerebellum development</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-29-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-29-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0021795">involved_in cerebral cortex cell migration</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-30-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-30-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0015871">involved_in choline transport</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-31-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-31-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0021904">involved_in dorsal/ventral neural tube patterning</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-32-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-32-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030326">involved_in embryonic limb morphogenesis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-33-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-33-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0032469">acts_upstream_of_or_within endoplasmic reticulum calcium ion homeostasis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-34-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-34-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/17431506" target="_blank" title="PubMed ID 17431506" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=17431506">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0032469">involved_in endoplasmic reticulum calcium ion homeostasis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-35-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-35-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16959576" target="_blank" title="PubMed ID 16959576" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=16959576">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0032469">involved_in endoplasmic reticulum calcium ion homeostasis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-36-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-36-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/25394380" target="_blank" title="PubMed ID 25394380" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=25394380">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0050673">involved_in epithelial cell proliferation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-37-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-37-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0001947">involved_in heart looping</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-38-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-38-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0002244">involved_in hematopoietic progenitor cell differentiation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-39-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-39-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0035556">involved_in intracellular signal transduction</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-40-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-40-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0007611">involved_in learning or memory</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-41-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-41-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20445063,24012003,24052308" target="_blank" title="PubMed ID 20445063,24012003,24052308" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=20445063,24012003,24052308">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0040011">involved_in locomotion</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-42-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-42-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006509">involved_in membrane protein ectodomain proteolysis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-43-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-43-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006509">involved_in membrane protein ectodomain proteolysis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-44-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-44-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/15274632" target="_blank" title="PubMed ID 15274632" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=15274632">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0007613">involved_in memory</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-45-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-45-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/11880515" target="_blank" title="PubMed ID 11880515" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=11880515">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006839">involved_in mitochondrial transport</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-46-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-46-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0043011">involved_in myeloid dendritic cell differentiation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-47-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-47-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0043066">involved_in negative regulation of apoptotic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-48-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-48-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/10805794" target="_blank" title="PubMed ID 10805794" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=10805794">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0043066">involved_in negative regulation of apoptotic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-49-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-49-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/10508860" target="_blank" title="PubMed ID 10508860" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=10508860">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:2001234">involved_in negative regulation of apoptotic signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-50-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-50-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0050771">involved_in negative regulation of axonogenesis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-51-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-51-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1904797">involved_in negative regulation of core promoter binding</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-52-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-52-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/10508860" target="_blank" title="PubMed ID 10508860" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=10508860">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0010629">involved_in negative regulation of gene expression</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-53-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-53-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/28008308,29061364" target="_blank" title="PubMed ID 28008308,29061364" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=28008308,29061364">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0043524">involved_in negative regulation of neuron apoptotic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-54-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-54-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0000122">involved_in negative regulation of transcription by RNA polymerase II</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-55-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-55-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/10508860" target="_blank" title="PubMed ID 10508860" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=10508860">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:2000059">involved_in negative regulation of ubiquitin-dependent protein catabolic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-56-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-56-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0003407">involved_in neural retina development</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-57-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-57-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051402">involved_in neuron apoptotic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-58-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-58-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0070050">involved_in neuron cellular homeostasis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-59-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-59-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0048666">involved_in neuron development</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-60-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-60-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0001764">involved_in neuron migration</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-61-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-61-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1990535">involved_in neuron projection maintenance</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-62-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-62-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/20445063" target="_blank" title="PubMed ID 20445063" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=20445063">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045893">involved_in positive regulation of DNA-templated transcription</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-63-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-63-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/23794287" target="_blank" title="PubMed ID 23794287" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=23794287">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0002038">involved_in positive regulation of L-glutamate import across plasma membrane</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-64-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-64-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:1905908">involved_in positive regulation of amyloid fibril formation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-65-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-65-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/11880515" target="_blank" title="PubMed ID 11880515" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=11880515">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0043065">involved_in positive regulation of apoptotic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-66-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-66-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0050820">involved_in positive regulation of coagulation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-67-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-67-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0060999">involved_in positive regulation of dendritic spine development</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-68-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-68-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/21951279" target="_blank" title="PubMed ID 21951279" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=21951279">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0010628">involved_in positive regulation of gene expression</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-69-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-69-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/28008308,29061364" target="_blank" title="PubMed ID 28008308,29061364" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=28008308,29061364">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045821">involved_in positive regulation of glycolytic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-70-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-70-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/29061364" target="_blank" title="PubMed ID 29061364" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=29061364">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0032436">involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-71-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-71-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042307">involved_in positive regulation of protein import into nucleus</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-72-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-72-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/10508860" target="_blank" title="PubMed ID 10508860" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=10508860">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0001921">involved_in positive regulation of receptor recycling</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-73-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-73-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0032760">involved_in positive regulation of tumor necrosis factor production</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-74-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-74-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/29061364" target="_blank" title="PubMed ID 29061364" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=29061364">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0009791">involved_in post-embryonic development</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-75-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-75-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0140249">involved_in protein catabolic process at postsynapse</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-76-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-76-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006486">involved_in protein glycosylation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-77-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-77-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0016485">involved_in protein processing</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-78-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-78-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0016485">involved_in protein processing</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-79-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-79-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/15274632,27608597" target="_blank" title="PubMed ID 15274632,27608597" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=15274632,27608597">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0016485">involved_in protein processing</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-80-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-80-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/12763021" target="_blank" title="PubMed ID 12763021" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=12763021">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0016485">involved_in protein processing</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-81-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-81-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/12297508" target="_blank" title="PubMed ID 12297508" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=12297508">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0015031">involved_in protein transport</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-82-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-82-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0060828">involved_in regulation of canonical Wnt signaling pathway</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-83-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
<div id="evidence-code-83-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0010468">involved_in regulation of gene expression</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-84-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-84-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/26200696" target="_blank" title="PubMed ID 26200696" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=26200696">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0010975">involved_in regulation of neuron projection development</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-85-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-85-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/15004326" target="_blank" title="PubMed ID 15004326" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=15004326">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042325">involved_in regulation of phosphorylation</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-86-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-86-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9689133" target="_blank" title="PubMed ID 9689133" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=9689133">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0099175">involved_in regulation of postsynapse organization</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-87-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-87-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0060075">involved_in regulation of resting membrane potential</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-88-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-88-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0048167">involved_in regulation of synaptic plasticity</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-89-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-89-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051966">involved_in regulation of synaptic transmission, glutamatergic</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-90-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-90-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0098693">involved_in regulation of synaptic vesicle cycle</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-91-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-91-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0006979">involved_in response to oxidative stress</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-92-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-92-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051208">involved_in sequestering of calcium ion</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-93-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-93-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0048705">involved_in skeletal system morphogenesis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-94-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-94-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0043589">involved_in skin morphogenesis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-95-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-95-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0051563">involved_in smooth endoplasmic reticulum calcium ion homeostasis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-96-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-96-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0001756">involved_in somitogenesis</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-97-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-97-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0050808">involved_in synapse organization</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-98-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-98-1" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/24012003" target="_blank" title="PubMed ID 24012003" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=24012003">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0016080">involved_in synaptic vesicle targeting</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-99-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-99-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
<tr>
<td headers="ont-comp">
<a href="http://amigo.geneontology.org/amigo/term/GO:0048538">involved_in thymus development</a>
</td>
<td headers="ont-evi-2 ont-evi-code-2">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-100-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-100-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-2 ont-pub-2"> </td>
</tr>
</tbody>
</table>
</div>
</div>
<div class="ui-ncbigrid-outer-div">
<div class="ui-ncbigrid-inner-div">
<table class="jig-ncbigrid" data-config="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
<thead>
<tr>
<th class="col1">Component</th>
<th style="width:12%;">Evidence Code</th>
<th style="width:10%;">Pubs</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005794">located_in Golgi apparatus</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-1-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/9246482,9632714,15274632" target="_blank" title="PubMed ID 9246482,9632714,15274632" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=9246482,9632714,15274632">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0000139">located_in Golgi membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-2-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0016235">located_in aggresome</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-3-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/21143716" target="_blank" title="PubMed ID 21143716" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=21143716">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0035577">located_in azurophil granule membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-4-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005938">located_in cell cortex</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-5-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030054">located_in cell junction</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-6-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0009986">located_in cell surface</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-7-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005813">located_in centrosome</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-8-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/9298903" target="_blank" title="PubMed ID 9298903" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=9298903">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0035253">located_in ciliary rootlet</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-9-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030425">is_active_in dendrite</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-10-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/24012003" target="_blank" title="PubMed ID 24012003" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=24012003">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0043198">located_in dendritic shaft</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-11-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0031901">located_in early endosome membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-12-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005783">located_in endoplasmic reticulum</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-13-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/9246482,15274632" target="_blank" title="PubMed ID 9246482,15274632" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=9246482,15274632">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005789">located_in endoplasmic reticulum membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-14-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0070765">part_of gamma-secretase complex</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-15-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
<div id="evidence-code-15-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0070765">part_of gamma-secretase complex</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-16-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-16-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/10801983,12297508,26280335" target="_blank" title="PubMed ID 10801983,12297508,26280335" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=10801983,12297508,26280335">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0070765">part_of gamma-secretase complex</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-17-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IGI</a>
<div id="evidence-code-17-2" class="ecode">Inferred from Genetic Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/12763021" target="_blank" title="PubMed ID 12763021" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=12763021">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0098978">located_in glutamatergic synapse</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-18-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-18-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0030426">located_in growth cone</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-19-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-19-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/15004326" target="_blank" title="PubMed ID 15004326" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=15004326">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0000776">located_in kinetochore</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-20-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-20-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/9298903" target="_blank" title="PubMed ID 9298903" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=9298903">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0016020">located_in membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-21-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-21-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/22375059,26280335" target="_blank" title="PubMed ID 22375059,26280335" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=22375059,26280335">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0016020">located_in membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-22-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-22-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/7596406" target="_blank" title="PubMed ID 7596406" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=7596406">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0045121">located_in membrane raft</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-23-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-23-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/20299451" target="_blank" title="PubMed ID 20299451" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=20299451">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005743">located_in mitochondrial inner membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-24-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-24-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005739">located_in mitochondrion</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-25-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-25-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/12377771" target="_blank" title="PubMed ID 12377771" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=12377771">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0031594">located_in neuromuscular junction</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-26-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-26-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0043005">located_in neuron projection</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-27-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-27-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/15004326" target="_blank" title="PubMed ID 15004326" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=15004326">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0043025">located_in neuronal cell body</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-28-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-28-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0031965">located_in nuclear membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-29-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-29-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/9298903" target="_blank" title="PubMed ID 9298903" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=9298903">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005640">located_in nuclear outer membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-30-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-30-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/9246482" target="_blank" title="PubMed ID 9246482" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=9246482">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005654">located_in nucleoplasm</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-31-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-31-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005634">located_in nucleus</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-32-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-32-2" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/10508860" target="_blank" title="PubMed ID 10508860" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=10508860">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">located_in plasma membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-33-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-33-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/15274632,21143716" target="_blank" title="PubMed ID 15274632,21143716" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=15274632,21143716">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">located_in plasma membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-34-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
<div id="evidence-code-34-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0098794">located_in postsynapse</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-35-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-35-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042734">located_in presynaptic membrane</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-36-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-36-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0032991">part_of protein-containing complex</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-37-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
<div id="evidence-code-37-2" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/10508860" target="_blank" title="PubMed ID 10508860" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=10508860">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005791">located_in rough endoplasmic reticulum</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-38-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-38-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/9632714" target="_blank" title="PubMed ID 9632714" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=9632714">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0042383">located_in sarcolemma</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-39-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-39-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005790">colocalizes_with smooth endoplasmic reticulum</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-40-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-40-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/10508860" target="_blank" title="PubMed ID 10508860" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=10508860">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0005790">located_in smooth endoplasmic reticulum</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-41-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
<div id="evidence-code-41-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/9632714" target="_blank" title="PubMed ID 9632714" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=9632714">PubMed</a> </td>
</tr>
<tr>
<td headers="ont-proc">
<a href="http://amigo.geneontology.org/amigo/term/GO:0008021">located_in synaptic vesicle</a>
</td>
<td headers="ont-evi-3 ont-evi-code-3">
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-42-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
<div id="evidence-code-42-2" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
</td>
<td headers="ont-evi-3 ont-pub-3"> </td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
</div>
</div>
</div>
<div class="rprt-section gene-general-protein-info">
<section class="rprt-section-header" id="general-protein-info">
<h2 id="header-general-protein-info">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-protein-info .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">General protein information</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.General_Protein_Information" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<dl>
<dt>Preferred Names</dt>
<dd>presenilin-1</dd>
</dl>
<dl>
<dt>Names</dt>
<dd>familial Alzheimer Disease</dd>
</dl>
<dl>
<dt class="heading">NP_000012.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/3.4.23.-">3.4.23.-</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">NP_015557.2</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/3.4.23.-">3.4.23.-</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_005267921.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/3.4.23.-">3.4.23.-</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_005267923.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/3.4.23.-">3.4.23.-</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_011535274.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/3.4.23.-">3.4.23.-</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_011535275.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/3.4.23.-">3.4.23.-</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_011535276.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/3.4.23.-">3.4.23.-</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047287556.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/3.4.23.-">3.4.23.-</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047287557.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/3.4.23.-">3.4.23.-</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_047287558.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/3.4.23.-">3.4.23.-</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054232388.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/3.4.23.-">3.4.23.-</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054232389.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/3.4.23.-">3.4.23.-</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054232390.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/3.4.23.-">3.4.23.-</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054232391.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/3.4.23.-">3.4.23.-</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054232392.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/3.4.23.-">3.4.23.-</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054232393.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/3.4.23.-">3.4.23.-</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054232394.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/3.4.23.-">3.4.23.-</a></li>
</ul>
</dd>
</dl>
<dl>
<dt class="heading">XP_054232395.1</dt>
<dd>
<ul class="geneinfo-subsec">
<li>EC <a href="http://enzyme.expasy.org/EC/3.4.23.-">3.4.23.-</a></li>
</ul>
</dd>
</dl>
</div>
</div>
<div class="rprt-section gene-reference-sequences">
<section class="rprt-section-header" id="reference-sequences">
<h2 id="header-reference-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-reference-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">NCBI Reference Sequences (RefSeq)</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.NCBI_Reference_Sequences_RefS" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<p>
<span class="new-icon">NEW</span>
<strong>Try the new <a href="/datasets/tables/genes/?table_type=transcripts&amp;ids=5663&amp;utm_source=gene&amp;utm_medium=referral&amp;utm_campaign=refseq" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report." data-ga-category="refseq" data-ga-action="click_datasets_link" data-ga-label="transcript_table">Transcript table</a></strong>
</p>
<h3 class="genomerefseqs gene_std_toggler" id="refseqset-independent">
<a class="jig-ncbitoggler-open">RefSeqs maintained independently of Annotated
Genomes</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> These reference sequences exist independently of genome builds. <a href="#refseq-expl" id="expl-refseg">Explain</a></p>
<p id="refseq-expl"> These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in <a href="#geneGenomic regions, transcripts, and products">Genomic regions,
transcripts, and products</a> above. </p>
<h4 id="genomic-p199131296">Genomic </h4>
<ol>
<li>
<p>NG_007386.2 RefSeqGene</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>5037..92221</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NG_007386.2?from=5037&amp;to=92221&amp;report=genbank" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=NG_007386.2?from=5037&amp;to=92221&amp;report=genbank">GenBank</a>, <a href="/nuccore/NG_007386.2?from=5037&amp;to=92221&amp;report=fasta" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=NG_007386.2?from=5037&amp;to=92221&amp;report=fasta">FASTA</a>, <a href="/nuccore/NG_007386.2?from=1&amp;to=105298&amp;report=graph&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=NG_007386.2?from=1&amp;to=105298&amp;report=graph&amp;content=5">Sequence Viewer (Graphics)</a>, <a href="ftp://ftp.ebi.ac.uk/pub/databases/lrgex/LRG_224.xml">LRG_224</a></dd>
</dl>
</li>
</ol>
<h4 id="mrnaandproteins-p150314512">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/NM_000021.4">NM_000021.4</a><a href="/protein/NP_000012.1">NP_000012.1</a>  presenilin-1 isoform I-467</p>
<p>
<a href="/ipg/NP_000012.1/" ref="ncbi_uid=5663">See identical proteins and their annotated locations for NP_000012.1</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (1) encodes the longer isoform (I-467).</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AK094186, AK312531, AW069286, BC011729, DA670846, DB075605, DB203403">AK094186, AK312531, AW069286, BC011729, DA670846, DB075605, DB203403</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS9812.1">CCDS9812.1</a>
</dd>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R6D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">B2R6D3</a>, <a href="https://www.uniprot.org/uniprot/O95465" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">O95465</a>, <a href="https://www.uniprot.org/uniprot/P49768" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">P49768</a>, <a href="https://www.uniprot.org/uniprot/Q14762" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q14762</a>, <a href="https://www.uniprot.org/uniprot/Q15719" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q15719</a>, <a href="https://www.uniprot.org/uniprot/Q15720" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q15720</a>, <a href="https://www.uniprot.org/uniprot/Q96P33" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q96P33</a>, <a href="https://www.uniprot.org/uniprot/Q9UIF0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q9UIF0</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A024R6A3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A024R6A3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN4</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN7</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP0</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP1</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGQ3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGQ3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGQ6" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGQ6</a></dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000326366.5" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">ENSP00000326366.5</a>, <a href="http://www.ensembl.org/id/ENST00000324501.10" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">ENST00000324501.10</a></dd>
<dt class="clear"> Conserved Domains (1) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_000012.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=395857">pfam01080</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">76</span><span class="cddto">457</span></dt>
<dd class="clearfix"> Presenilin</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/NM_007318.3">NM_007318.3</a><a href="/protein/NP_015557.2">NP_015557.2</a>  presenilin-1 isoform I-463</p>
<p>
<a href="/ipg/NP_015557.2/" ref="ncbi_uid=5663">See identical proteins and their annotated locations for NP_015557.2</a>
</p>
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
<dl>
<dt>Description</dt>
<dd>Transcript Variant: This variant (2) uses an alternative donor splice site at one of the coding exons compared to transcript variant 1. It maintains the same reading frame, and encodes a shorter isoform (I-463) missing a 4 aa peptide compared to isoform I-467.</dd>
<dt>Source sequence(s)</dt>
<dd class="wordwrap">
<a href="/nuccore/AK094186, AW069286, BC011729, DA670846, DB075605, DB203403">AK094186, AW069286, BC011729, DA670846, DB075605, DB203403</a>
</dd>
<dt>Consensus CDS</dt>
<dd>
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&amp;GO=MainBrowse&amp;DATA=CCDS9813.1">CCDS9813.1</a>
</dd>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A0S2Z4D2" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A0S2Z4D2</a>, <a href="https://www.uniprot.org/uniprot/Q53FV8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q53FV8</a></dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000350342.4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">ENSP00000350342.4</a>, <a href="http://www.ensembl.org/id/ENST00000357710.8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">ENST00000357710.8</a></dd>
<dt class="clear"> Conserved Domains (1) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_015557.2">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=395857">pfam01080</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">72</span><span class="cddto">453</span></dt>
<dd class="clearfix"> Presenilin</dd>
</dl>
</dd>
</dl>
</li>
</ol>
</div>
<h3 class="genomerefseqs gene_std_toggler" id="annotatedrefseq-title">
<a class="jig-ncbitoggler-open">RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> The following sections contain reference sequences that belong to a
specific genome build. <a href="#" id="expl-genomes">Explain</a></p>
<p id="expl-genomes-desc" style="display:none">This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.</p>
<h3 id="refseq-sequencedescription-p148563632">Reference GRCh38.p14 Primary Assembly</h3>
<h4 id="genomic-p148563632">Genomic </h4>
<ol>
<li>
<p>NC_000014.9 Reference GRCh38.p14 Primary Assembly</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>73136417..73223691</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_000014.9?from=73136417&amp;to=73223691&amp;report=genbank" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=NC_000014.9?from=73136417&amp;to=73223691&amp;report=genbank">GenBank</a>, <a href="/nuccore/NC_000014.9?from=73136417&amp;to=73223691&amp;report=fasta" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=NC_000014.9?from=73136417&amp;to=73223691&amp;report=fasta">FASTA</a>, <a href="/nuccore/NC_000014.9?from=73123325&amp;to=73236781&amp;report=graph&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=NC_000014.9?from=73123325&amp;to=73236781&amp;report=graph&amp;content=5">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h4 id="mrnaandproteins-p196110512">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/XM_047431602.1">XM_047431602.1</a><a href="/protein/XP_047287558.1">XP_047287558.1</a>  presenilin-1 isoform X2</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A0S2Z4D2" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A0S2Z4D2</a>, <a href="https://www.uniprot.org/uniprot/Q53FV8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q53FV8</a></dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000514901.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">ENSP00000514901.1</a>, <a href="http://www.ensembl.org/id/ENST00000700265.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">ENST00000700265.1</a></dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047431601.1">XM_047431601.1</a><a href="/protein/XP_047287557.1">XP_047287557.1</a>  presenilin-1 isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R6D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">B2R6D3</a>, <a href="https://www.uniprot.org/uniprot/O95465" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">O95465</a>, <a href="https://www.uniprot.org/uniprot/P49768" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">P49768</a>, <a href="https://www.uniprot.org/uniprot/Q14762" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q14762</a>, <a href="https://www.uniprot.org/uniprot/Q15719" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q15719</a>, <a href="https://www.uniprot.org/uniprot/Q15720" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q15720</a>, <a href="https://www.uniprot.org/uniprot/Q96P33" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q96P33</a>, <a href="https://www.uniprot.org/uniprot/Q9UIF0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q9UIF0</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A024R6A3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A024R6A3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN4</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN7</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP0</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP1</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGQ3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGQ3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGQ6" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGQ6</a></dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000514903.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">ENSP00000514903.1</a>, <a href="http://www.ensembl.org/id/ENST00000700267.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">ENST00000700267.1</a></dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_047431600.1">XM_047431600.1</a><a href="/protein/XP_047287556.1">XP_047287556.1</a>  presenilin-1 isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R6D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">B2R6D3</a>, <a href="https://www.uniprot.org/uniprot/O95465" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">O95465</a>, <a href="https://www.uniprot.org/uniprot/P49768" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">P49768</a>, <a href="https://www.uniprot.org/uniprot/Q14762" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q14762</a>, <a href="https://www.uniprot.org/uniprot/Q15719" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q15719</a>, <a href="https://www.uniprot.org/uniprot/Q15720" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q15720</a>, <a href="https://www.uniprot.org/uniprot/Q96P33" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q96P33</a>, <a href="https://www.uniprot.org/uniprot/Q9UIF0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q9UIF0</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A024R6A3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A024R6A3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN4</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN7</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP0</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP1</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGQ3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGQ3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGQ6" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGQ6</a></dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_011536974.3">XM_011536974.3</a><a href="/protein/XP_011535276.1">XP_011535276.1</a>  presenilin-1 isoform X2</p>
<p>
<a href="/ipg/XP_011535276.1/" ref="ncbi_uid=5663">See identical proteins and their annotated locations for XP_011535276.1</a>
</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A0S2Z4D2" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A0S2Z4D2</a>, <a href="https://www.uniprot.org/uniprot/Q53FV8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q53FV8</a></dd>
<dt class="clear"> Conserved Domains (1) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011535276.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=395857">pfam01080</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">72</span><span class="cddto">453</span></dt>
<dd class="clearfix"> Presenilin</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_011536972.3">XM_011536972.3</a><a href="/protein/XP_011535274.1">XP_011535274.1</a>  presenilin-1 isoform X1</p>
<p>
<a href="/ipg/XP_011535274.1/" ref="ncbi_uid=5663">See identical proteins and their annotated locations for XP_011535274.1</a>
</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R6D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">B2R6D3</a>, <a href="https://www.uniprot.org/uniprot/O95465" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">O95465</a>, <a href="https://www.uniprot.org/uniprot/P49768" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">P49768</a>, <a href="https://www.uniprot.org/uniprot/Q14762" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q14762</a>, <a href="https://www.uniprot.org/uniprot/Q15719" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q15719</a>, <a href="https://www.uniprot.org/uniprot/Q15720" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q15720</a>, <a href="https://www.uniprot.org/uniprot/Q96P33" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q96P33</a>, <a href="https://www.uniprot.org/uniprot/Q9UIF0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q9UIF0</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A024R6A3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A024R6A3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN4</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN7</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP0</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP1</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGQ3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGQ3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGQ6" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGQ6</a></dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000514968.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">ENSP00000514968.1</a>, <a href="http://www.ensembl.org/id/ENST00000700378.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">ENST00000700378.1</a></dd>
<dt class="clear"> Conserved Domains (1) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011535274.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=395857">pfam01080</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">76</span><span class="cddto">457</span></dt>
<dd class="clearfix"> Presenilin</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_011536973.3">XM_011536973.3</a><a href="/protein/XP_011535275.1">XP_011535275.1</a>  presenilin-1 isoform X2</p>
<p>
<a href="/ipg/XP_011535275.1/" ref="ncbi_uid=5663">See identical proteins and their annotated locations for XP_011535275.1</a>
</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A0S2Z4D2" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A0S2Z4D2</a>, <a href="https://www.uniprot.org/uniprot/Q53FV8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q53FV8</a></dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000377719.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">ENSP00000377719.1</a>, <a href="http://www.ensembl.org/id/ENST00000394164.5" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">ENST00000394164.5</a></dd>
<dt class="clear"> Conserved Domains (1) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_011535275.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=395857">pfam01080</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">72</span><span class="cddto">453</span></dt>
<dd class="clearfix"> Presenilin</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_005267864.4">XM_005267864.4</a><a href="/protein/XP_005267921.1">XP_005267921.1</a>  presenilin-1 isoform X1</p>
<p>
<a href="/ipg/XP_005267921.1/" ref="ncbi_uid=5663">See identical proteins and their annotated locations for XP_005267921.1</a>
</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R6D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">B2R6D3</a>, <a href="https://www.uniprot.org/uniprot/O95465" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">O95465</a>, <a href="https://www.uniprot.org/uniprot/P49768" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">P49768</a>, <a href="https://www.uniprot.org/uniprot/Q14762" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q14762</a>, <a href="https://www.uniprot.org/uniprot/Q15719" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q15719</a>, <a href="https://www.uniprot.org/uniprot/Q15720" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q15720</a>, <a href="https://www.uniprot.org/uniprot/Q96P33" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q96P33</a>, <a href="https://www.uniprot.org/uniprot/Q9UIF0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q9UIF0</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A024R6A3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A024R6A3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN4</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN7</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP0</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP1</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGQ3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGQ3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGQ6" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGQ6</a></dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000514904.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">ENSP00000514904.1</a>, <a href="http://www.ensembl.org/id/ENST00000700268.1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">ENST00000700268.1</a></dd>
<dt class="clear"> Conserved Domains (1) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_005267921.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=395857">pfam01080</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">76</span><span class="cddto">457</span></dt>
<dd class="clearfix"> Presenilin</dd>
</dl>
</dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_005267866.3">XM_005267866.3</a><a href="/protein/XP_005267923.1">XP_005267923.1</a>  presenilin-1 isoform X2</p>
<p>
<a href="/ipg/XP_005267923.1/" ref="ncbi_uid=5663">See identical proteins and their annotated locations for XP_005267923.1</a>
</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A0S2Z4D2" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A0S2Z4D2</a>, <a href="https://www.uniprot.org/uniprot/Q53FV8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q53FV8</a></dd>
<dt>Related</dt>
<dd><a href="http://www.ensembl.org/id/ENSP00000450551.2" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">ENSP00000450551.2</a>, <a href="http://www.ensembl.org/id/ENST00000556951.6" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">ENST00000556951.6</a></dd>
<dt class="clear"> Conserved Domains (1) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_005267923.1">summary</a></dt>
<dd>
<dl class="level2">
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=395857">pfam01080</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">72</span><span class="cddto">453</span></dt>
<dd class="clearfix"> Presenilin</dd>
</dl>
</dd>
</dl>
</li>
</ol>
<h3 id="refseq-sequencedescription-p134334480">Alternate T2T-CHM13v2.0</h3>
<h4 id="genomic-p134334480">Genomic </h4>
<ol>
<li>
<p>NC_060938.1 Alternate T2T-CHM13v2.0</p>
<dl>
<dt>Range</dt>
<dd class="rs-range">
<span>67341963..67429152</span>
</dd>
<dt>Download</dt>
<dd><a href="/nuccore/NC_060938.1?from=67341963&amp;to=67429152&amp;report=genbank" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=NC_060938.1?from=67341963&amp;to=67429152&amp;report=genbank">GenBank</a>, <a href="/nuccore/NC_060938.1?from=67341963&amp;to=67429152&amp;report=fasta" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=NC_060938.1?from=67341963&amp;to=67429152&amp;report=fasta">FASTA</a>, <a href="/nuccore/NC_060938.1?from=67328884&amp;to=67442229&amp;report=graph&amp;content=5" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=NC_060938.1?from=67328884&amp;to=67442229&amp;report=graph&amp;content=5">Sequence Viewer (Graphics)</a></dd>
</dl>
</li>
</ol>
<h4 id="mrnaandproteins-p197326832">mRNA and Protein(s) </h4>
<ol>
<li>
<p><a href="/nuccore/XM_054376420.1">XM_054376420.1</a><a href="/protein/XP_054232395.1">XP_054232395.1</a>  presenilin-1 isoform X2</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A0S2Z4D2" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A0S2Z4D2</a>, <a href="https://www.uniprot.org/uniprot/Q53FV8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q53FV8</a></dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054376415.1">XM_054376415.1</a><a href="/protein/XP_054232390.1">XP_054232390.1</a>  presenilin-1 isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R6D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">B2R6D3</a>, <a href="https://www.uniprot.org/uniprot/O95465" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">O95465</a>, <a href="https://www.uniprot.org/uniprot/P49768" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">P49768</a>, <a href="https://www.uniprot.org/uniprot/Q14762" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q14762</a>, <a href="https://www.uniprot.org/uniprot/Q15719" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q15719</a>, <a href="https://www.uniprot.org/uniprot/Q15720" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q15720</a>, <a href="https://www.uniprot.org/uniprot/Q96P33" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q96P33</a>, <a href="https://www.uniprot.org/uniprot/Q9UIF0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q9UIF0</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A024R6A3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A024R6A3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN4</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN7</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP0</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP1</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGQ3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGQ3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGQ6" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGQ6</a></dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054376414.1">XM_054376414.1</a><a href="/protein/XP_054232389.1">XP_054232389.1</a>  presenilin-1 isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R6D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">B2R6D3</a>, <a href="https://www.uniprot.org/uniprot/O95465" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">O95465</a>, <a href="https://www.uniprot.org/uniprot/P49768" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">P49768</a>, <a href="https://www.uniprot.org/uniprot/Q14762" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q14762</a>, <a href="https://www.uniprot.org/uniprot/Q15719" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q15719</a>, <a href="https://www.uniprot.org/uniprot/Q15720" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q15720</a>, <a href="https://www.uniprot.org/uniprot/Q96P33" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q96P33</a>, <a href="https://www.uniprot.org/uniprot/Q9UIF0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q9UIF0</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A024R6A3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A024R6A3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN4</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN7</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP0</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP1</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGQ3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGQ3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGQ6" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGQ6</a></dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054376418.1">XM_054376418.1</a><a href="/protein/XP_054232393.1">XP_054232393.1</a>  presenilin-1 isoform X2</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A0S2Z4D2" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A0S2Z4D2</a>, <a href="https://www.uniprot.org/uniprot/Q53FV8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q53FV8</a></dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054376416.1">XM_054376416.1</a><a href="/protein/XP_054232391.1">XP_054232391.1</a>  presenilin-1 isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R6D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">B2R6D3</a>, <a href="https://www.uniprot.org/uniprot/O95465" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">O95465</a>, <a href="https://www.uniprot.org/uniprot/P49768" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">P49768</a>, <a href="https://www.uniprot.org/uniprot/Q14762" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q14762</a>, <a href="https://www.uniprot.org/uniprot/Q15719" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q15719</a>, <a href="https://www.uniprot.org/uniprot/Q15720" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q15720</a>, <a href="https://www.uniprot.org/uniprot/Q96P33" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q96P33</a>, <a href="https://www.uniprot.org/uniprot/Q9UIF0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q9UIF0</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A024R6A3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A024R6A3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN4</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN7</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP0</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP1</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGQ3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGQ3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGQ6" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGQ6</a></dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054376419.1">XM_054376419.1</a><a href="/protein/XP_054232394.1">XP_054232394.1</a>  presenilin-1 isoform X2</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A0S2Z4D2" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A0S2Z4D2</a>, <a href="https://www.uniprot.org/uniprot/Q53FV8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q53FV8</a></dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054376413.1">XM_054376413.1</a><a href="/protein/XP_054232388.1">XP_054232388.1</a>  presenilin-1 isoform X1</p>
<dl>
<dt>UniProtKB/Swiss-Prot</dt>
<dd><a href="https://www.uniprot.org/uniprot/B2R6D3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">B2R6D3</a>, <a href="https://www.uniprot.org/uniprot/O95465" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">O95465</a>, <a href="https://www.uniprot.org/uniprot/P49768" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">P49768</a>, <a href="https://www.uniprot.org/uniprot/Q14762" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q14762</a>, <a href="https://www.uniprot.org/uniprot/Q15719" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q15719</a>, <a href="https://www.uniprot.org/uniprot/Q15720" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q15720</a>, <a href="https://www.uniprot.org/uniprot/Q96P33" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q96P33</a>, <a href="https://www.uniprot.org/uniprot/Q9UIF0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q9UIF0</a></dd>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A024R6A3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A024R6A3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN4" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN4</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGN7" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGN7</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP0" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP0</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP1" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP1</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGP3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGP3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGQ3" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGQ3</a>, <a href="https://www.uniprot.org/uniprot/A0A218KGQ6" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A218KGQ6</a></dd>
</dl>
</li>
<li>
<p><a href="/nuccore/XM_054376417.1">XM_054376417.1</a><a href="/protein/XP_054232392.1">XP_054232392.1</a>  presenilin-1 isoform X2</p>
<dl>
<dt>UniProtKB/TrEMBL</dt>
<dd><a href="https://www.uniprot.org/uniprot/A0A0S2Z4D2" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">A0A0S2Z4D2</a>, <a href="https://www.uniprot.org/uniprot/Q53FV8" ref="itool=Gene_FullReport&amp;PrId=5380&amp;uid=5663&amp;nlmid=&amp;db=gene">Q53FV8</a></dd>
</dl>
</li>
</ol>
</div>
<h3 class="genomerefseqs gene_std_toggler">
<a class="jig-ncbitoggler">Suppressed Reference Sequence(s)</a>
</h3>
<div class="genomerefseqs_slave">
<p class="desc"> The following Reference Sequences have been suppressed. <a href="#expl-suppressed-desc" id="expl-suppressed">Explain</a></p>
<p id="expl-suppressed-desc" style="display:none">These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.</p>
<ol>
<li>
<p><a href="/nuccore/7549814">NM_007319.1</a>: Suppressed sequence</p>
<dl>
<dt>Description</dt>
<dd>NM_007319.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.</dd>
</dl>
</li>
</ol>
</div>
</div>
</div>
<div class="rprt-section gene-related-sequences">
<section class="rprt-section-header" id="related-sequences">
<h2 id="header-related-sequences">
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-related-sequences .rprt-section-body'">
<span class="ui-ncbitoggler-master-text">Related sequences</span>
</a>
</h2>
<div class="rprt-section-tools">
<a href="#top" title="Go to the top of the page" class="gene-top-page">
<span>Go to the top of the page</span>
</a>
<a href="/books/NBK3841/#EntrezGene.Related_Sequences" title="Help" class="gene-section-help">
<span>Help</span>
</a>
</div>
</section>
<div class="rprt-section-body">
<div>
<table id="proteinTblId" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/5663/data/related-sequences/',webserviceParams: 'p$l=Ajax', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
<thead>
<tr>
<th colspan="2" id="rs-nucleo">Nucleotide</th>
<th rowspan="2" id="rs-protein">Protein</th>
</tr>
<tr>
<th id="rs-heading">Heading</th>
<th id="rs-heading-acc">Accession and Version</th>
</tr>
</thead>
<tbody></tbody>
</table>
<table id="proteinTblId" class="jig-ncbigrid" data-jigconfig="isPageable:true, pageSize:25">
<thead>
<tr>
<th class="proteinTblTh" rowspan="2" id="rs-prot-acc">Protein Accession</th>
<th class="proteinTblTh" colspan="2" id="rs-link">Links</th>
</tr>
<tr>
<th id="rs-genepept">GenPept Link</th>
<th id="rs-uniprot">UniProtKB Link</th>
</tr>
</thead>
<tbody>
<tr>
<td headers="rs-prot-acc">P49768.1</td>
<td headers="rs-link rs-genepept">
<a href="/protein/1709856" ref="ordinalpos=1&amp;ncbi_uid=5663&amp;link_uid=1709856">GenPept</a>
</td>
<td>
<a href="https://www.uniprot.org/uniprot/P49768">UniProtKB/Swiss-Prot:P49768</a>
</td>
</tr>
</tbody>
</table>
</div>
</div>
</div>
<div class="rprt-section gene-additional-links">
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
<div class="rprt-section-body" style="">
<div id="lsdb"><h3 class="withnote" id="locusspecificdatabases"><a class="jig-ncbitoggler-open">Locus-specific Databases</a></h3><div><ul class="locusdb"><li><a href="http://www.molgen.ua.ac.be/ADMutations/default.cfm?MT=1&amp;ML=0&amp;Page=ADMDB" ref="from_uid=5663" class="lsdblink">Alzheimer Disease &amp; Frontotemporal Dementia Mutation Database</a></li><li><a href="http://alsod.iop.kcl.ac.uk/Als/Overview/gene.aspx?gene_id=PSEN1" ref="from_uid=5663" class="lsdblink">ALSoD/PSEN1 genetic mutations</a></li><li><a href="https://lovd.nl/PSEN1" ref="from_uid=5663" class="lsdblink">PSEN1 database</a></li></ul></div></div>
<h3 class="withnote" id="genelinkout">
<a class="jig-ncbitoggler">Gene LinkOut</a>
</h3><div>
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
<div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Chemical Information</span>
</a>
<ul>
<li><span class="free-rsc"></span>Interologous Interaction Database</li>
<ul>
<li>
<a target="_blank" href="http://ophid.utoronto.ca/redirect/ncbi/human?proteins=5663" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7911">
<span>Interologous Interaction Database</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>MilliporeSigma</li>
<ul>
<li>
<a target="_blank" href="https://www.sigmaaldrich.com/catalog/genes/PSEN1?lang=en&amp;region=US" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9978">
<span>Psen1 products</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Medical</span>
</a>
<ul>
<li><span class="free-rsc"></span>MedlinePlus Health Information</li>
<ul>
<li>
<a target="_blank" href="https://medlineplus.gov/genetics/gene/psen1" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=3162">
<span>PSEN1 gene</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Molecular Biology Databases</span>
</a>
<ul>
<li><span class="free-rsc"></span>Bgee database</li>
<ul>
<li>
<a target="_blank" href="https://www.bgee.org/gene/ENSG00000080815" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10418">
<span>PSEN1 gene expression</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGPS</li>
<ul>
<li>
<a target="_blank" href="http://biogps.org/gene/5663/" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5059">
<span>BioGPS</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>BioGRID Open Repository of CRISPR Screens (ORCS)</li>
<ul>
<li>
<a target="_blank" href="https://orcs.thebiogrid.org/Gene/5663" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10164">
<span>BioGRID CRISPR Screen Phenotypes (22 hits/1371 screens)</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Eukaryotic Promoter Database</li>
<ul>
<li>
<a target="_blank" href="http://epd.vital-it.ch/cgi-bin/get_doc?db=hgEpdNew&amp;format=genome&amp;entry=PSEN1_1" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9624">
<span>PSEN1_1</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>GenAge Database of Aging Related Genes</li>
<ul>
<li>
<a target="_blank" href="http://genomics.senescence.info/genes/entry.php?hgnc=PSEN1" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=6827">
<span>GenAge Database of Aging Related Genes</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>GlyGen glycoinformatics resource</li>
<ul>
<li>
<a target="_blank" href="https://glygen.org/protein/P49768" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10227">
<span>GlyGen glycoinformatics resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Guide to Pharmacology</li>
<ul>
<li>
<a target="_blank" href="https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8191">
<span>presenilin 1 gene</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span><span class="regis-rsc"></span>Human Gene Mutation Database</li>
<ul>
<li>
<a target="_blank" href="http://www.hgmd.cf.ac.uk/ac/gene.php?gene=PSEN1" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=3100">
<span>Human Gene Mutation Database</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Human eFP Browser</li>
<ul>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Reproductive&amp;modeInput=Absolute&amp;primaryGene=5663" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Skeletal_Immune_Digestive&amp;modeInput=Absolute&amp;primaryGene=5663" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
<li>
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Nervous&amp;modeInput=Absolute&amp;primaryGene=5663" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8875">
<span>Human eFP Browser</span>
</a>
</li>
</ul>
<li>Ingenuity Pathways Analysis</li>
<ul>
<li>
<a target="_blank" href="http://partnersolution.ingenuity.com/?cid=97ae3f91eab87a&amp;p1=Entrez&amp;p2=GV&amp;s=&amp;ipaUri=%2Fpa%2Fapi%2Fv2%2Fgeneview%3Fapplicationname%3DEntrez%26geneId%3D5663%26geneidtype%3Dentrezgene" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5628">
<span>Ingenuity Pathways Analysis</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InnateDB</li>
<ul>
<li>
<a target="_blank" href="http://www.innatedb.com/getGeneCard.do?id=11235" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7894">
<span>InnateDB</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>InterMine</li>
<ul>
<li>
<a target="_blank" href="https://www.humanmine.org/humanmine/search?keyword=ENSG00000080815" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9169">
<span>InterMine</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>Kyoto Encyclopedia of Genes and Genomes</li>
<ul>
<li>
<a target="_blank" href="http://www.genome.jp/dbget-bin/www_bget?hsa:5663" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5174">
<span>Kyoto Encyclopedia of Genes and Genomes</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OMA Browser: Orthologous MAtrix</li>
<ul>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN20136/" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN20146/" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
<li>
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN20145/" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=9822">
<span>OMA Browser: Orthologous MAtrix</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>OrthoDB catalog of orthologs</li>
<ul>
<li>
<a target="_blank" href="https://www.orthodb.org/?ncbi=5663" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8178">
<span>Orthologs</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>PhosphoSitePlus</li>
<ul>
<li>
<a target="_blank" href="https://www.phosphosite.org/entrezGeneIdAction.action?id=5663" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7987">
<span>PhosphoSitePlus® - comprehensive post-translational modification resource</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Gene Wiki</li>
<ul>
<li>
<a target="_blank" href="https://en.wikipedia.org/wiki/PSEN1" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=6933">
<span>The Gene Wiki</span>
</a>
</li>
</ul>
<li><span class="free-rsc"></span>The Weizmann Institute of Science GeneCards and MalaCards databases</li>
<ul>
<li>
<a target="_blank" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=PSEN1" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8598">
<span>GeneCard for PSEN1</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Research Materials</span>
</a>
<ul>
<li><span class="order-rsc"></span>Addgene Non-profit plasmid repository</li>
<ul>
<li>
<a target="_blank" href="https://addgene.org//browse/gene/5663" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5304">
<span>Get Plasmids - Addgene</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Bio-Techne</li>
<ul>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/presenilin-1/proteins-enzymes?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=proteins" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>Presenilin-1 Proteins</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/presenilin-1/elisa-kits?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=elisakits" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>Presenilin-1 ELISA Kits</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.bio-techne.com/t/presenilin-1/antibodies?utm_source=linkout&amp;utm_medium=referral&amp;utm_campaign=product&amp;utm_term=antibodies" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8242">
<span>Presenilin-1 Antibodies</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Creative Biogene</li>
<ul>
<li>
<a target="_blank" href="https://www.creative-biogene.com/genesearch/PSEN1.html" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=10094">
<span>presenilin 1</span>
</a>
</li>
</ul>
<li>ExactAntigen/Labome</li>
<ul>
<li>
<a target="_blank" href="https://www.labome.com/gene/human/PS1-antibody.html" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagents</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.labome.com/review/gene/human/PS1-antibody.html" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=5753">
<span>reagent review</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GenScript latest version of gene cDNA ORF Clone</li>
<ul>
<li>
<a target="_blank" href="http://www.genscript.com/gene/5663" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8012">
<span>GenScript latest version of gene cDNA ORF Clone</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GeneCopoeia Inc.</li>
<ul>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=1&amp;field=5&amp;key=5663" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order full-length ORF clone</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=22&amp;field=5&amp;key=5663" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order promoter clone</span>
</a>
</li>
<li>
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=11&amp;field=5&amp;key=5663" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7255">
<span>Order shRNA clones</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>GeneTex Inc</li>
<ul>
<li>
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=5663&amp;type=01&amp;page=1" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=8117">
<span>Find Quality Antibodies</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>Kazusa DNA Research Institute</li>
<ul>
<li>
<a target="_blank" href="http://www.kazusa.or.jp/kop/dsearch/symsearch.cgi?keyword=PSEN1;" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=3267">
<span>Kazusa DNA Research Institute</span>
</a>
</li>
</ul>
<li><span class="order-rsc"></span>OriGene</li>
<ul>
<li>
<a target="_blank" href="https://www.origene.com/search?q=PSEN1" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7994">
<span>Order PSEN1 cDNA clone/Protein/Antibody/RNAi</span>
</a>
</li>
</ul>
</ul>
</div>
<div class="linkout">
<a class="jig-ncbitoggler-open main">
<span>Tools</span>
</a>
<ul>
<li><span class="free-rsc"></span>GeneMANIA</li>
<ul>
<li>
<a target="_blank" href="http://genemania.org/link?o=9606&amp;g=5663" ref="itool=Gene_FullReport&amp;uid=5663&amp;nlmid=&amp;db=gene&amp;log$=linkoutlink&amp;PrId=7529">
<span>GeneMANIA</span>
</a>
</li>
</ul>
</ul>
</div>
</div>
</div>
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</div>
</div>
</div>
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<!-- sidebar close/hide button-->
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<h2 class="offscreen_noflow">Supplemental Content</h2>
<div id="gene-sidebar">
<div>
<div class="portlet brieflink dis-table-of-contents">
<div class="portlet_head">
<div class="portlet_title">
<h3>Table of contents</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li class="">
<a href="#summary">Summary</a>
</li>
<li class="">
<a href="#genomic-context">Genomic context</a>
</li>
<li class="">
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
</li>
<li class="">
<a href="#gene-expression">Expression</a>
</li>
<li class="">
<a href="#bibliography">Bibliography</a>
</li>
<li class="">
<a href="#phenotypes">Phenotypes</a>
</li>
<li class="">
<a href="#variation">Variation</a>
</li>
<li class="">
<a href="#pathways">Pathways from PubChem</a>
</li>
<li class="">
<a href="#interactions">Interactions</a>
</li>
<li class="">
<a href="#general-gene-info">General gene information</a>
<div class="subsection-links"><a href="#gene-markers">Markers</a>, <a href="#homology">Homology</a>, <a href="#gene-ontology">Gene Ontology</a></div>
</li>
<li class="">
<a href="#general-protein-info">General protein information</a>
</li>
<li class="">
<a href="#reference-sequences">NCBI Reference Sequences (RefSeq)</a>
</li>
<li class="">
<a href="#related-sequences">Related sequences</a>
</li>
<li class="">
<a href="#additional-links">Additional links</a>
<div class="subsection-links">
<a href="#lsdb">Locus-specific Databases</a>
</div>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
<div class="portlet_head">
<div class="portlet_title">
<h3>Genome Browsers</h3>
</div>
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</li>
</ul>
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<div class="portlet dis-related-info brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related information</h3>
</div>
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</div>
<div class="portlet_content DiscoveryDbLinks">
<ul>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clone/order/gene/5663" ref="log$=recordlinks">Order cDNA clone</a>
<div class="brieflinkpop offscreen_noflow">Order cDNA clone</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/structure?LinkName=gene_structure&amp;from_uid=5663" ref="log$=recordlinks">3D structures</a>
<div class="brieflinkpop offscreen_noflow">3D structure of a gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_alltarget_list&amp;from_uid=5663" ref="log$=recordlinks">BioAssay by Target (List)</a>
<div class="brieflinkpop offscreen_noflow">BioAssays related to the gene by protein target or RNAi target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="//pubchem.ncbi.nlm.nih.gov/assay/bioactivity.html?geneid=5663" ref="log$=recordlinks">BioAssay by Target (Summary)</a>
<div class="brieflinkpop offscreen_noflow">Summarized PubChem Data on the gene, showing the active data by default</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_target&amp;from_uid=5663" ref="log$=recordlinks">BioAssay, by Gene target</a>
<div class="brieflinkpop offscreen_noflow">PubChem BioAssays done on the Gene target</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai_active&amp;from_uid=5663" ref="log$=recordlinks">BioAssays, RNAi Target, Active</a>
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent, which is identified as a hit in a RNAi screening and flagged as "active" in the corresponding BioAssay record</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai&amp;from_uid=5663" ref="log$=recordlinks">BioAssays, RNAi Target, Tested</a>
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&amp;from_uid=5663" ref="log$=recordlinks">BioProjects</a>
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/biosystems?LinkName=gene_biosystems&amp;from_uid=5663" ref="log$=recordlinks">BioSystems</a>
<div class="brieflinkpop offscreen_noflow">BioSystems</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/CCDS/CcdsBrowse.cgi?REQUEST=GENEID&amp;DATA=5663" ref="log$=recordlinks">CCDS</a>
<div class="brieflinkpop offscreen_noflow">Link to CCDS</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar&amp;from_uid=5663" ref="log$=recordlinks">ClinVar</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/cdd?LinkName=gene_cdd&amp;from_uid=5663" ref="log$=recordlinks">Conserved Domains</a>
<div class="brieflinkpop offscreen_noflow">Related CDD</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/dbvar?LinkName=gene_dbvar&amp;from_uid=5663" ref="log$=recordlinks">dbVar</a>
<div class="brieflinkpop offscreen_noflow">Link from Gene to dbVar</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&amp;from_uid=5663" ref="log$=recordlinks">Full text in PMC</a>
<div class="brieflinkpop offscreen_noflow">PMC links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&amp;from_uid=5663" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/sparcle?LinkName=gene_sparcle&amp;from_uid=5663" ref="log$=recordlinks">Functional Class</a>
<div class="brieflinkpop offscreen_noflow">Functional class of the sequence domain architecture</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&amp;from_uid=5663" ref="log$=recordlinks">Gene neighbors</a>
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_h3k4me3&amp;from_uid=5663" ref="log$=recordlinks">Genes with a similar H3K4me3 profile</a>
<div class="brieflinkpop offscreen_noflow">Genes with a similar profile of promoter-activating H3K4me3 modifications across several tissue types</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/genome?LinkName=gene_genome&amp;from_uid=5663" ref="log$=recordlinks">Genome</a>
<div class="brieflinkpop offscreen_noflow">Related Genome</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/geoprofiles?LinkName=gene_geoprofiles&amp;from_uid=5663" ref="log$=recordlinks">GEO Profiles</a>
<div class="brieflinkpop offscreen_noflow">Related GEO</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gtr/tests/?term=5663[geneid]" ref="log$=recordlinks">GTR</a>
<div class="brieflinkpop offscreen_noflow">Tests for this gene in the NIH Genetic Testing Registry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/homologene?LinkName=gene_homologene&amp;from_uid=5663" ref="log$=recordlinks">HomoloGene</a>
<div class="brieflinkpop offscreen_noflow">Related HomoloGene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/medgen?LinkName=gene_medgen_diseases&amp;from_uid=5663" ref="log$=recordlinks">MedGen</a>
<div class="brieflinkpop offscreen_noflow">Related information in MedGen</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&amp;from_uid=5663" ref="log$=recordlinks">Nucleotide</a>
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/omim?LinkName=gene_omim&amp;from_uid=5663" ref="log$=recordlinks">OMIM</a>
<div class="brieflinkpop offscreen_noflow">Link to related OMIM entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/probe?LinkName=gene_probe&amp;from_uid=5663" ref="log$=recordlinks">Probe</a>
<div class="brieflinkpop offscreen_noflow">Related Probe entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein&amp;from_uid=5663" ref="log$=recordlinks">Protein</a>
<div class="brieflinkpop offscreen_noflow">Link to related protein entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pccompound?LinkName=gene_pccompound&amp;from_uid=5663" ref="log$=recordlinks">PubChem Compound</a>
<div class="brieflinkpop offscreen_noflow">PubChem Compounds</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pcsubstance?LinkName=gene_pcsubstance&amp;from_uid=5663" ref="log$=recordlinks">PubChem Substance</a>
<div class="brieflinkpop offscreen_noflow">PubChem Substances</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&amp;from_uid=5663" ref="log$=recordlinks">PubMed</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_rif&amp;from_uid=5663" ref="log$=recordlinks">PubMed (GeneRIF)</a>
<div class="brieflinkpop offscreen_noflow">Link to related PubMed article from GeneRIFs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_citedinomim&amp;from_uid=5663" ref="log$=recordlinks">PubMed (OMIM)</a>
<div class="brieflinkpop offscreen_noflow">Gene links to PubMed derived from omim_pubmed_cited links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&amp;from_uid=5663" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein_refseq&amp;from_uid=5663" ref="log$=recordlinks">RefSeq Proteins</a>
<div class="brieflinkpop offscreen_noflow">Link to Protein RefSeqs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore_refseqrna&amp;from_uid=5663" ref="log$=recordlinks">RefSeq RNAs</a>
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeq RNAs</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/nuccore/213511787?report=graph" ref="log$=recordlinks">RefSeqGene</a>
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeqGenes</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar_specific&amp;from_uid=5663" ref="log$=recordlinks">Related gene-specific medical variations</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/snp?LinkName=gene_snp&amp;from_uid=5663" ref="log$=recordlinks">SNP</a>
<div class="brieflinkpop offscreen_noflow">Related SNP records</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&amp;from_uid=5663" ref="log$=recordlinks">Taxonomy</a>
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/variation/view/?q=5663[geneid]" ref="log$=recordlinks">Variation Viewer</a>
<div class="brieflinkpop offscreen_noflow">Related Variants</div>
</li>
</ul>
</div>
</div>
<div class="portlet dis-links-to-other-res brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Links to other resources</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_LinksTwo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9508">HGNC</a>
</li>
<li>
<a href="http://www.ensembl.org/id/ENSG00000080815">Ensembl</a>
</li>
<li>
<a href="https://www.alliancegenome.org/gene/HGNC:9508">AllianceGenome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&amp;org=9606&amp;l=5663">AceView</a>
</li>
<li>
<a href="http://alsod.iop.kcl.ac.uk/Als/Overview/gene.aspx?gene_id=PSEN1">ALSoD/PSEN1 genetic mutations</a>
</li>
<li>
<a href="http://www.molgen.ua.ac.be/ADMutations/default.cfm?MT=1&amp;ML=0&amp;Page=ADMDB">Alzheimer Disease &amp; Frontotemporal Dementia Mutation Database</a>
</li>
<li>
<a href="https://lovd.nl/PSEN1">PSEN1 database</a>
</li>
<li>
<a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&amp;position=NM_000021">UCSC</a>
</li>
<li>
<a href="https://genecollections.nci.nih.gov/MGC/?ORG=Hs&amp;LIST=BC011729">MGC</a>
</li>
<li>
<a href="https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=PSEN1&amp;geneID=5663&amp;typeOption=gene&amp;which=2&amp;pubOrderType=pubD&amp;typeSubmit=GO&amp;check=y">HuGE Navigator</a>
</li>
<li>
<a href="http://www.genome.jp/dbget-bin/www_bget?hsa:5663">KEGG</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-general-info">
<div class="portlet_head">
<div class="portlet_title">
<h3>General information</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GeneralInfo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="/pmc/?term=PMC4383897+OR+PMC3013746+OR+PMC1761442+OR+PMC539985">About Gene</a>
</li>
<li>
<a href="/books/NBK3840">FAQ</a>
</li>
<li>
<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
</li>
<li>
<a href="/books/NBK3841/">Help</a>
</li>
<li>
<a href="/books/NBK3842/">My NCBI help</a>
</li>
<li>
<a href="/books/NBK21085/">NCBI Handbook</a>
</li>
<li>
<a href="/gene/statistics/">Statistics</a>
</li>
</ul>
</div>
</div>
<div class="portlet brieflink dis-related-sites">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related sites</h3>
</div>
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_RelatedSites" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/genome">Genome</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/">Genome Data Viewer</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/geo">GEO</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/omim">OMIM</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
</li>
</ul>
</div>
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<h3>Feedback</h3>
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<li>
<a href="https://support.ncbi.nlm.nih.gov/ics/support/ticketnewwizard.asp?style=classic&amp;deptID=28049">Contact Help Desk</a>
</li>
<li>
<a href="https://www.ncbi.nlm.nih.gov/RefSeq/update.cgi?geneid=5663&amp;symbol=PSEN1">Submit Correction</a>
</li>
<li>
<a href="/gene/submit-generif?geneId=5663&amp;sym=PSEN1&amp;name=presenilin 1&amp;org=Homo sapiens">Submit GeneRIF</a>
</li>
</ul>
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<h3>Subscription</h3>
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<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Subscription" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter"></a>
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<div class="portlet_content">
<ul>
<li>
<a href="https://www.ncbi.nlm.nih.gov/mailman/listinfo/refseq-announce">RefSeq</a>
</li>
</ul>
</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67dbb49b2f30673f7b190455">PSEN1 presenilin 1 [Homo sapiens]</a>
<div class="ralinkpop offscreen_noflow">PSEN1 presenilin 1 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:5663</div></div>
<div class="tertiary">Gene</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67dbb49984f3725e5948c68d">Early-Onset Familial Alzheimer Disease RETIRED CHAPTER, FOR HISTORICAL REFEREN...</a>
<div class="ralinkpop offscreen_noflow">Early-Onset Familial Alzheimer Disease RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY - GeneReviews®<div class="brieflinkpopdesc"></div></div>
<div class="tertiary"></div>
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<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67dbb46e2f30673f7b181e9d">RecName: Full=Bacteriocin lactococcin-G subunit alpha</a>
<div class="ralinkpop offscreen_noflow">RecName: Full=Bacteriocin lactococcin-G subunit alpha<div class="brieflinkpopdesc">gi|547831|sp|P36961.1|LCGA_LACLL</div></div>
<div class="tertiary">Protein</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67dbb45867c23b31e0d706e5">Homo sapiens establishment of cohesion 1 homolog 2 (ESCO2) mRNA, complete cds</a>
<div class="ralinkpop offscreen_noflow">Homo sapiens establishment of cohesion 1 homolog 2 (ESCO2) mRNA, complete cds<div class="brieflinkpopdesc">gi|62131653|gb|AY882862.1|</div></div>
<div class="tertiary">Nucleotide</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67dbb453cde49f3df70eab98">TPA: hypothetical protein BOS_22221 [Bos taurus]</a>
<div class="ralinkpop offscreen_noflow">TPA: hypothetical protein BOS_22221 [Bos taurus]<div class="brieflinkpopdesc">gi|296473829|tpg|DAA15944.1||gnl|lc 9932267.46</div></div>
<div class="tertiary">Protein</div>
</li>
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