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3965 lines
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319 KiB
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<h1 class="res_name"><a href="/gene/">Gene</a></h1>
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<h2 class="res_tagline">Genes and mapped phenotypes</h2>
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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pubmed">PubMed</option><option value="clinvar">ClinVar</option><option value="medgen">MedGen</option><option value="books" class="last">Books</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" selected="selected" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<input name="EntrezSystem2.PEntrez.Gene.Gene_PageController.PreviousPageName" sid="1" type="hidden" value="results" />
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<h2 class="offscreen_noflow">Result Filters</h2>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'2778',linkname:'',idsfromresult:'1234',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="genomic">Genomic</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="alt-splicing">Alternatively spliced</a></li><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li><li class="fil_val"><a href="#" data-value_id="gene-type-protein-coding">Protein-coding</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="seq-ccds">CCDS</a></li><li class="fil_val"><a href="#" data-value_id="seq-ensembl">Ensembl</a></li><li class="fil_val"><a href="#" data-value_id="refseq">RefSeq</a></li><li class="fil_val"><a href="#" data-value_id="seq-refseqgene">RefSeqGene</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67c9d82c69195c35ad6ba5dd" data-hid="MCID_67c90f2d64f30b25346ccae2" data-qky="2778" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
|
||
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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|
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<span style="display: block; text-align: center;">S</span>
|
||
<span style="display: block; text-align: center;">I</span>
|
||
<span style="display: block; text-align: center;">D</span>
|
||
<span style="display: block; text-align: center;">E</span>
|
||
<span style="display: block; text-align: center;">B</span>
|
||
<span style="display: block; text-align: center;">A</span>
|
||
<span style="display: block; text-align: center;">R</span>
|
||
</div>
|
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|
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<div class="results_settings one_setting"><ul class="inline_list left display_settings"><li><a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Display" sid="0" href="#" class="jig-ncbipopper" data-jigconfig="triggerPosition : 'bottom center',destPosition : 'top center',destSelector : '#display_settings_menu_report', hasArrow : false,openEvent : 'click',closeEvent : 'click',isTriggerElementCloseClick: false,addCloseButton : false, groupName: 'entrez_pg'" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Display">Full Report<span href="#" class="tgt_dark"></span></a></li></ul><div id="display_settings_menu_report" class="disp_settings tabPopper"><fieldset class="format"><legend>Format</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="1" value="full_report" format="" id="full_report" checked="true" /><label for="full_report">Full Report</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="2" value="full_report" format="text" id="full_reporttext" /><label for="full_reporttext">Full Report (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="3" value="expression" format="" id="expression" /><label for="expression">Expression</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="4" value="gene_table" format="" id="gene_table" /><label for="gene_table">Gene Table</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="5" value="gene_table" format="text" id="gene_tabletext" /><label for="gene_tabletext">Gene Table (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="6" value="generif" format="" id="generif" /><label for="generif">GeneRIF</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="7" value="docsum" format="" id="docsum" /><label for="docsum">Summary</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="8" value="docsum" format="text" id="docsumtext" /><label for="docsumtext">Summary (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="9" value="tabular" format="" id="tabular" /><label for="tabular">Tabular</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="10" value="tabular" format="text" id="tabulartext" /><label for="tabulartext">Tabular (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="11" value="asn1" format="text" id="asn1text" /><label for="asn1text">ASN.1</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="12" value="xml" format="text" id="xmltext" /><label for="xmltext">XML</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="13" value="uilist" format="text" id="uilisttext" /><label for="uilisttext">UI List</label></li></ul></fieldset></div><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SetDisplay" sid="1" class="button_apply ncbipopper-close-button" style="display:none">Apply</button><h4 class="content_header send_to align_right jig-ncbipopper" id="sendto" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#send_to_menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, addCloseButton:true, groupName: 'entrez_pg', adjustFit:'none'"><a href="#" sourceContent="send_to_menu" class="tgt_dark">Send to:</a><script type="text/javascript">
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jQuery("#send_to_menu div.submenu:visible").css("display","none");
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</script></h4><div id="send_to_menu" class="tabPopper send_to"><fieldset><legend>Choose Destination</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="1" value="File" id="dest_File" /><label for="dest_File">File</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="2" value="AddToClipboard" id="dest_AddToClipboard" /><label for="dest_AddToClipboard">Clipboard</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="3" value="AddToCollections" id="dest_AddToCollections" /><label for="dest_AddToCollections">Collections</label></li></ul></fieldset><div class="submenu file" id="submenu_File" style="display: none;"><p id="submenu_File_hint" class="hidden"></p><ul><li><label for="file_format">Format</label><select id="file_format" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FFormat" sid="1"><option value="full_report" format="text" selected="selected">Full Report (text)</option><option value="gene_table" format="text">Gene Table (text)</option><option value="docsum" format="text">Summary (text)</option><option value="tabular" format="text">Tabular (text)</option><option value="asn1" format="text">ASN.1</option><option value="xml" format="text">XML</option><option value="uilist" format="text">UI List</option></select></li></ul><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="1" class="button_apply file ncbipopper-close-button" type="submit" cmd="File">Create File</button></div><div class="submenu addtoclipboard" id="submenu_AddToClipboard" style="display: none;"><p id="submenu_AddToClipboard_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="2" class="button_apply clipboard ncbipopper-close-button" type="submit" cmd="AddToClipboard">Add to Clipboard</button></div><div class="submenu addtocollections" id="submenu_AddToCollections" style="display: none;"><p id="submenu_AddToCollections_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="3" class="button_apply collections ncbipopper-close-button" type="submit" cmd="AddToCollections">Add to Collections</button></div></div><div><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FileFormat" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastPresentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Presentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Sort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastSort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FileSort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Format" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastFormat" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevPresentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevSort" sid="1" type="hidden" value="" /><input type="hidden" id="coll_startindex" name="CollectionStartIndex" value="1" /></div></div>
|
||
<div>
|
||
|
||
|
||
|
||
</div>
|
||
<div class="">
|
||
<div><span id="result_sel" class="nowrap"></span><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_ResultsController.ResultCount" sid="1" type="hidden" id="resultcount" value="1" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_ResultsController.RunLastQuery" sid="1" type="hidden" /></div>
|
||
|
||
</div>
|
||
<div id="messagearea" class="empty">
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div class="rprt full-rprt">
|
||
<div>
|
||
<div class="rprt-header">
|
||
<input type="hidden" id="gene-tax-id" value="9606" />
|
||
<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">CCR5</span> C-C motif chemokine receptor 5 [ <em class="tax">Homo sapiens</em> (human)
|
||
]
|
||
</h1>
|
||
<span class="geneid">Gene ID: 1234, updated on
|
||
4-Mar-2025</span>
|
||
</div>
|
||
<div class="download-datasets">
|
||
<script type="text/javascript" src="https://cdnjs.cloudflare.com/ajax/libs/axios/0.23.0/axios.min.js"></script>
|
||
<h4 class="download-datasets-popper jig-ncbipopper" id="download-asm" style="align-self:start" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#download-datasets-popper-menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, groupName: 'entrez_pg', adjustFit:'none'" role="button" aria-expanded="false" aria-haspopup="true">
|
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<svg alt="download" class="dlbtn-icon" x="0px" y="0px" width="15px" height="15px" viewBox="0 0 60 60" enable-background="new 0 0 60 60" xml:space="preserve">
|
||
<g>
|
||
<polygon points="48.75,36.25 48.75,48.75 11.25,48.75 11.25,36.25 5,36.25 5,55 55,55 55,36.25 "></polygon>
|
||
<polygon points="42.5,23.75 36.25,23.75 36.25,5 23.75,5 23.75,23.75 17.5,23.75 30,42.5 "></polygon>
|
||
</g>
|
||
</svg>
|
||
<a href="#">Download Datasets</a>
|
||
</h4>
|
||
<div id="download-datasets-popper-menu" style="display:none;">
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-gene-seq-fasta" value="FASTA_GENE" checked="checked" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-gene-seq-fasta">Gene Sequences (FASTA)</label>
|
||
</div>
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-transcript-seq-fasta" value="FASTA_RNA" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-transcript-seq-fasta">Transcript sequences (FASTA)</label>
|
||
</div>
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-protein-seq-fasta" value="FASTA_PROTEIN" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-protein-seq-fasta">Protein sequences(FASTA)</label>
|
||
</div>
|
||
<p style="margin-left:5px;">In addition, your package will include a detailed data report in both TSV and JSONL formats.</p>
|
||
<div class="input-group">
|
||
<label for="datasets-download-file-name">File name</label>
|
||
<input type="text" id="datasets-download-file-name" placeholder="Name your file" style="padding:5px;" value="CCR5_datasets.zip" />
|
||
</div>
|
||
<input type="hidden" id="download-datasets-base-url" value="https://api.ncbi.nlm.nih.gov/datasets/v2alpha/gene/download" />
|
||
<input type="hidden" id="gene-id-value" value="1234" />
|
||
<button id="datasets-download-submit" data-ga-action="click_begin_download" data-ga-label="download" class="jig-ncbibutton ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-gray" role="button">
|
||
<span class="ui-button-text">Download</span>
|
||
</button>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-body">
|
||
|
||
|
||
<div class="rprt-section gene-summary">
|
||
<section class="rprt-section-header" id="summary">
|
||
<h2 id="header-summary">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-summary .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Summary</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Summary_2" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div id="summaryDiv" class="section">
|
||
<dl id="summaryDl">
|
||
<dt class="noline"> Official
|
||
Symbol</dt>
|
||
<dd class="noline">CCR5<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
|
||
<dt> Official
|
||
Full Name</dt>
|
||
<dd>C-C motif chemokine receptor 5<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
|
||
<dt>Primary source</dt>
|
||
<dd>
|
||
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1606" data-gblink-text="Ensembl">HGNC:HGNC:1606</a>
|
||
</dd>
|
||
<dt>See related</dt>
|
||
<dd>
|
||
<a href="http://www.ensembl.org/id/ENSG00000160791" data-gblink-text="Ensembl" class="genome-browser-link" data-genome-browser-link-sort="5" data-gb-url="http://www.ensembl.org/loc/ENSG00000160791">Ensembl:ENSG00000160791</a>
|
||
<a href="https://www.ncbi.nlm.nih.gov/omim/601373" data-gblink-text="Ensembl" ref="ordinalpos=1&ncbi_uid=1234&link_uid=601373">MIM:601373;</a>
|
||
<a href="https://www.alliancegenome.org/gene/HGNC:1606" data-gblink-text="Ensembl" ref="ordinalpos=1&ncbi_uid=1234&link_uid=HGNC:1606">AllianceGenome:HGNC:1606</a>
|
||
</dd>
|
||
<dt>Gene type</dt>
|
||
<dd>protein coding</dd>
|
||
<dt>RefSeq status</dt>
|
||
<dd>REVIEWED</dd>
|
||
<dt>Organism</dt>
|
||
<dd class="tax">
|
||
<a href="/Taxonomy/Browser/wwwtax.cgi?id=9606" ref="ordinalpos=1&ncbi_uid=1234&link_uid=9606">Homo sapiens</a>
|
||
</dd>
|
||
<dt>Lineage</dt>
|
||
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dd>
|
||
<dt>Also known as</dt>
|
||
<dd>CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5</dd>
|
||
<dt>Summary</dt>
|
||
<dd>This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]</dd>
|
||
<dt>Annotation information</dt>
|
||
<dd>Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.</dd>
|
||
<dt>Expression</dt>
|
||
<dd>Broad expression in appendix (RPKM 9.4), lymph node (RPKM 7.4) and 21 other tissues <a href="#gene-expression">See more</a></dd>
|
||
<dt>Orthologs</dt>
|
||
<dd class="ortholog-links">
|
||
<a href="/gene/1234/ortholog/">all</a>
|
||
</dd>
|
||
<dt style="padding-top:.5em;">
|
||
<span class="new-icon">NEW</span>
|
||
</dt>
|
||
<dd style="padding-top:.5em;">
|
||
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/1234/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
|
||
<br />
|
||
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/1234/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
|
||
</dd>
|
||
</dl>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-genomic-context">
|
||
<section class="rprt-section-header" id="genomic-context">
|
||
<h2 id="header-genomic-context">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-context .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Genomic context</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Genomic_Context" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div class="gc_cont">
|
||
<div class="gt_cont_contents">
|
||
<div style="float:right"><span>See CCR5 in </span><a href="/genome/gdv/?context=gene&acc=1234" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="GCF_000001405.40">Genome Data Viewer</a> </div>
|
||
<dl class="dl-chr-info" style="float:left;margin-top:0;">
|
||
<dt>Location: </dt>
|
||
<dd>
|
||
<span style="display:inline-block;">3p21.31</span>
|
||
</dd>
|
||
</dl>
|
||
</div>
|
||
<dl class="dl-chr-info exon-count">
|
||
<dt>Exon count: </dt>
|
||
<dd>3</dd>
|
||
</dl>
|
||
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="">
|
||
<thead>
|
||
<tr>
|
||
<th style="max-width:15%">Annotation release</th>
|
||
<th style="max-width:10%">Status</th>
|
||
<th>Assembly</th>
|
||
<th>
|
||
<span title="Chromosome">Chr</span>
|
||
</th>
|
||
<th>Location</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td>RS_2024_08</td>
|
||
<td>current</td>
|
||
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=1234&link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
|
||
<td>3</td>
|
||
<td>NC_000003.12 (46370142..46376206) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>RS_2024_08</td>
|
||
<td>current</td>
|
||
<td>T2T-CHM13v2.0 (<a href="/assembly/GCF_009914755.1/" ref="ncbi_uid=1234&link_uid=GCF_009914755.1">GCF_009914755.1</a>)</td>
|
||
<td>3</td>
|
||
<td>NC_060927.1 (46385976..46392040) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>RS_2024_09</td>
|
||
<td>previous assembly</td>
|
||
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=1234&link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
|
||
<td>3</td>
|
||
<td>NC_000003.11 (46411633..46417697) </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<p class="withnote margin_t2em"><strong>Chromosome 3 - NC_000003.12</strong><img usemap="#nbrMap1234_568815595" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=1234&nuc_gi=568815595&n0=UQCRC2P1&n1=LOC129661025&n2=LOC129936641&n3=CCR2&n4=CCR5AS&n5=CCR5&n6=LOC129936642&n7=LOC127397272&n8=LOC127397273&n9=LOC129936643&n10=CCRL2&n11=LINC02009" /><map name="nbrMap1234_568815595" id="nbrMap1234_568815595">
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ubiquinol-cytochrome c reductase core protein 2 pseudogene 1')" onMouseOut="hidetip()" coords="22,23,72,31" alt="Neighboring gene ubiquinol-cytochrome c reductase core protein 2 pseudogene 1" href="/gene/100131327" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ReSE screen-validated silencer GRCh37_chr3:46386020-46386226')" onMouseOut="hidetip()" coords="110,23,180,31" alt="Neighboring gene ReSE screen-validated silencer GRCh37_chr3:46386020-46386226" href="/gene/129661025" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 19796')" onMouseOut="hidetip()" coords="128,35,198,43" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19796" href="/gene/129936641" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'C-C motif chemokine receptor 2')" onMouseOut="hidetip()" coords="181,23,224,31" alt="Neighboring gene C-C motif chemokine receptor 2" href="/gene/729230" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'CCR5 antisense RNA')" onMouseOut="hidetip()" coords="202,35,370,43" alt="Neighboring gene CCR5 antisense RNA" href="/gene/102724297" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 14288')" onMouseOut="hidetip()" coords="218,47,288,55" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14288" href="/gene/129936642" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'NANOG hESC enhancer GRCh37_chr3:46421718-46422219')" onMouseOut="hidetip()" coords="223,59,293,67" alt="Neighboring gene NANOG hESC enhancer GRCh37_chr3:46421718-46422219" href="/gene/127397272" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac hESC enhancer GRCh37_chr3:46434353-46434852')" onMouseOut="hidetip()" coords="263,71,333,79" alt="Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:46434353-46434852" href="/gene/127397273" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 14289')" onMouseOut="hidetip()" coords="266,83,336,91" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14289" href="/gene/129936643" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'C-C motif chemokine receptor like 2')" onMouseOut="hidetip()" coords="344,23,379,31" alt="Neighboring gene C-C motif chemokine receptor like 2" href="/gene/9034" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'long intergenic non-protein coding RNA 2009')" onMouseOut="hidetip()" coords="353,47,423,55" alt="Neighboring gene long intergenic non-protein coding RNA 2009" href="/gene/105377068" />
|
||
</map>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-genomic-regions-transcripts-products">
|
||
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
|
||
<h2 id="header-genomic-regions-transcripts-products">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Genomic_Regions_Transcripts_a" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
|
||
</div>
|
||
<div>
|
||
<p class="choose">
|
||
<label for="accession" class="label">Genomic Sequence: </label>
|
||
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="9606" data-geneid="1234">
|
||
<option value="NC_000003.12_46370141_46376205">NC_000003.12 Chromosome 3 Reference GRCh38.p14 Primary Assembly</option>
|
||
<option value="NG_012637.1_5804_11064">NG_012637.1 RefSeqGene</option>
|
||
<option value="NC_060927.1_46385975_46392039">NC_060927.1 Chromosome 3 Alternate T2T-CHM13v2.0</option>
|
||
<option value="NC_000003.11_46411632_46417696">NC_000003.11 Chromosome 3 Reference GRCh37.p13 Primary Assembly</option>
|
||
</select>
|
||
</p>
|
||
</div>
|
||
<div id="NC_000003" class="divAccession">
|
||
<div class="seq-viewer">
|
||
<p class="note-link">
|
||
<strong>Go to nucleotide:</strong>
|
||
<a title="Nucleotide Graphic report" href="/nuccore/NC_000003.12?report=graph&from=46369231&to=46377115&app_context=Gene&assm_context=GCF_000001405.40" ref="ordinalpos=1&ncbi_uid=1234&link_uid=NC_000003.12">Graphics</a>
|
||
<a title="Nucleotide FASTA report" href="/nuccore/NC_000003.12?report=fasta&from=46370142&to=46376206" ref="ordinalpos=1&ncbi_uid=1234&link_uid=NC_000003.12">FASTA</a>
|
||
<a title="Nucleotide GenBank report" href="/nuccore/NC_000003.12?report=genbank&from=46370142&to=46376206" ref="ordinalpos=1&ncbi_uid=1234&link_uid=NC_000003.12">GenBank</a>
|
||
</p>
|
||
<div id="divNC_000003" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&embedded=true&noslider=1&id=NC_000003.12&from=46369231&to=46377115&app_context=Gene&assm_context=GCF_000001405.40">
|
||
<a href="?appname=ncbigene&embedded=true&noslider=1&id=NC_000003.12&from=46369231&to=46377115&app_context=Gene&assm_context=GCF_000001405.40"></a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000003.12" sid="1" type="hidden" id="nucleotideLink_NC_000003_12_46370141_46376205" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_000003.12?report=graph&amp;from=46369231&amp;to=46377115&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=1234&amp;link_uid=NC_000003.12">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_000003.12?report=fasta&amp;from=46370142&amp;to=46376206" ref="ordinalpos=1&amp;ncbi_uid=1234&amp;link_uid=NC_000003.12">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_000003.12?report=genbank&amp;from=46370142&amp;to=46376206" ref="ordinalpos=1&amp;ncbi_uid=1234&amp;link_uid=NC_000003.12">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000003.12" sid="1" type="hidden" id="relString_NC_000003_12_46370141_46376205" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000003.12&amp;from=46369231&amp;to=46377115&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NG_012637.1" sid="1" type="hidden" id="nucleotideLink_NG_012637_1_5804_11064" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NG_012637.1?report=graph&amp;from=5015&amp;to=11853&amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:ShowAllButGenes,SNPs:false,CDSProductFeats:false,ShowLabelsForAllFeatures:true,HighlightMode:2][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results][key:alignment_track,category:Alignments,annots:Unnamed][key:alignment_track,category:Alignments,annots:NA000079160.1][key:alignment_track,category:Alignments,annots:NA000010065.1]" ref="ordinalpos=1&amp;ncbi_uid=1234&amp;link_uid=NG_012637.1">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NG_012637.1?report=fasta&amp;from=5805&amp;to=11065" ref="ordinalpos=1&amp;ncbi_uid=1234&amp;link_uid=NG_012637.1">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NG_012637.1?report=genbank&amp;from=5805&amp;to=11065" ref="ordinalpos=1&amp;ncbi_uid=1234&amp;link_uid=NG_012637.1">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NG_012637.1" sid="1" type="hidden" id="relString_NG_012637_1_5804_11064" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NG_012637.1&amp;from=5015&amp;to=11853&amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes---Unnamed,display_name:Genes,annots:Unnamed,Options:ShowAllButGenes,SNPs:false,CDSProductFeats:false,ShowLabelsForAllFeatures:true,HighlightMode:2][key:SNP_track,name:SNP,annots:SNP,Layout:Adaptive][key:SNP_Bins_track,name:Clinical Variants][key:SNP_Bins_track,name:Cited Variants][key:GWAS_track,name:GWAS Tracks,display_name:Association Results][key:alignment_track,category:Alignments,annots:Unnamed][key:alignment_track,category:Alignments,annots:NA000079160.1][key:alignment_track,category:Alignments,annots:NA000010065.1]" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_060927.1" sid="1" type="hidden" id="nucleotideLink_NC_060927_1_46385975_46392039" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_060927.1?report=graph&amp;from=46385065&amp;to=46392949&amp;app_context=Gene&amp;assm_context=GCF_009914755.1" ref="ordinalpos=1&amp;ncbi_uid=1234&amp;link_uid=NC_060927.1">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_060927.1?report=fasta&amp;from=46385976&amp;to=46392040" ref="ordinalpos=1&amp;ncbi_uid=1234&amp;link_uid=NC_060927.1">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_060927.1?report=genbank&amp;from=46385976&amp;to=46392040" ref="ordinalpos=1&amp;ncbi_uid=1234&amp;link_uid=NC_060927.1">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_060927.1" sid="1" type="hidden" id="relString_NC_060927_1_46385975_46392039" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_060927.1&amp;from=46385065&amp;to=46392949&amp;app_context=Gene&amp;assm_context=GCF_009914755.1" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000003.11" sid="1" type="hidden" id="nucleotideLink_NC_000003_11_46411632_46417696" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_000003.11?report=graph&amp;from=46410722&amp;to=46418606&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" ref="ordinalpos=1&amp;ncbi_uid=1234&amp;link_uid=NC_000003.11">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_000003.11?report=fasta&amp;from=46411633&amp;to=46417697" ref="ordinalpos=1&amp;ncbi_uid=1234&amp;link_uid=NC_000003.11">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_000003.11?report=genbank&amp;from=46411633&amp;to=46417697" ref="ordinalpos=1&amp;ncbi_uid=1234&amp;link_uid=NC_000003.11">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000003.11" sid="1" type="hidden" id="relString_NC_000003_11_46411632_46417696" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000003.11&amp;from=46410722&amp;to=46418606&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" />
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-gene-expression">
|
||
<section class="rprt-section-header" id="gene-expression">
|
||
<h2 id="header-gene-expression">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-gene-expression .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Expression</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Expression" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<div style="text-align:right;">
|
||
<a href="/gene/1234/?report=expression" data-url="/gene/1234/?report=expression" id="gene-expression-see-details">See details</a>
|
||
</div>
|
||
<div id="gene-expression-app" data-url="https://www.ncbi.nlm.nih.gov/gene/1234" data-report-type="summary">
|
||
<div>
|
||
<script type="text/javascript">
|
||
|
||
window.tissues_data = {'adrenal 10wk': {'id': '1234_Adrenal_10wk_PRJNA270632', 'gene': 1234, 'source_name': 'adrenal 10wk', 'full_rpkm': 0.0840344, 'exp_rpkm': 0.084, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389860139046}, 'adrenal 16wk': {'id': '1234_Adrenal_16wk_PRJNA270632', 'gene': 1234, 'source_name': 'adrenal 16wk', 'full_rpkm': 0.0223951, 'exp_rpkm': 0.0224, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389860139047}, 'adrenal 18wk': {'id': '1234_Adrenal_18wk_PRJNA270632', 'gene': 1234, 'source_name': 'adrenal 18wk', 'full_rpkm': 0.0397321, 'exp_rpkm': 0.0397, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389860139048}, 'adrenal 20wk': {'id': '1234_Adrenal_20wk_PRJNA270632', 'gene': 1234, 'source_name': 'adrenal 20wk', 'full_rpkm': 0.0363875, 'exp_rpkm': 0.0364, 'var': 5.79882e-06, 'project_desc': 'PRJNA270632', '_version_': 1785734389860139049}, 'heart 10wk': {'id': '1234_Heart_10wk;_PRJNA270632', 'gene': 1234, 'source_name': 'heart 10wk', 'full_rpkm': 0.0519173, 'exp_rpkm': 0.0519, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389860139050}, 'heart 11wk': {'id': '1234_Heart_11wk;_PRJNA270632', 'gene': 1234, 'source_name': 'heart 11wk', 'full_rpkm': 0.019047, 'exp_rpkm': 0.019, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389860139051}, 'heart 17wk': {'id': '1234_Heart_17wk;_PRJNA270632', 'gene': 1234, 'source_name': 'heart 17wk', 'full_rpkm': 0.013817, 'exp_rpkm': 0.0138, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389860139052}, 'heart 18wk': {'id': '1234_Heart_18wk;_PRJNA270632', 'gene': 1234, 'source_name': 'heart 18wk', 'full_rpkm': 0.0174654, 'exp_rpkm': 0.0175, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389860139053}, 'heart 20wk': {'id': '1234_Heart_20wk_PRJNA270632', 'gene': 1234, 'source_name': 'heart 20wk', 'full_rpkm': 0.0326286, 'exp_rpkm': 0.0326, 'var': 0.0002391498, 'project_desc': 'PRJNA270632', '_version_': 1785734389861187584}, 'intestine 10wk': {'id': '1234_Intestine_10wk_PRJNA270632', 'gene': 1234, 'source_name': 'intestine 10wk', 'full_rpkm': 0.0274891, 'exp_rpkm': 0.0275, 'var': 0.0001192162, 'project_desc': 'PRJNA270632', '_version_': 1785734389861187585}, 'intestine 11wk': {'id': '1234_Intestine_11wk_PRJNA270632', 'gene': 1234, 'source_name': 'intestine 11wk', 'full_rpkm': 0.010775, 'exp_rpkm': 0.0108, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389861187586}, 'intestine 15wk': {'id': '1234_Intestine_15wk_PRJNA270632', 'gene': 1234, 'source_name': 'intestine 15wk', 'full_rpkm': 0.267697, 'exp_rpkm': 0.268, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389861187587}, 'intestine 17wk': {'id': '1234_Intestine_17wk_PRJNA270632', 'gene': 1234, 'source_name': 'intestine 17wk', 'full_rpkm': 0.109789, 'exp_rpkm': 0.11, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389861187588}, 'intestine 20wk': {'id': '1234_Intestine_20wk_PRJNA270632', 'gene': 1234, 'source_name': 'intestine 20wk', 'full_rpkm': 0.224016, 'exp_rpkm': 0.224, 'var': 0.003082, 'project_desc': 'PRJNA270632', '_version_': 1785734389861187589}, 'kidney 10wk': {'id': '1234_Kidney_10wk_PRJNA270632', 'gene': 1234, 'source_name': 'kidney 10wk', 'full_rpkm': 0.0771082, 'exp_rpkm': 0.0771, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389861187590}, 'kidney 16wk': {'id': '1234_Kidney_16wk_PRJNA270632', 'gene': 1234, 'source_name': 'kidney 16wk', 'full_rpkm': 0.00979095, 'exp_rpkm': 0.00979, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389861187591}, 'kidney 20wk': {'id': '1234_Kidney_20wk_PRJNA270632', 'gene': 1234, 'source_name': 'kidney 20wk', 'full_rpkm': 0.0163676, 'exp_rpkm': 0.0164, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389861187592}, 'lung 10wk': {'id': '1234_Lung_10wk_PRJNA270632', 'gene': 1234, 'source_name': 'lung 10wk', 'full_rpkm': 0.0186709, 'exp_rpkm': 0.0187, 'var': 0.0001808878, 'project_desc': 'PRJNA270632', '_version_': 1785734389861187593}, 'lung 17wk': {'id': '1234_Lung_17wk_PRJNA270632', 'gene': 1234, 'source_name': 'lung 17wk', 'full_rpkm': 0.0749783, 'exp_rpkm': 0.075, 'var': 0.001302162, 'project_desc': 'PRJNA270632', '_version_': 1785734389861187594}, 'lung 20wk': {'id': '1234_Lung_20wk_PRJNA270632', 'gene': 1234, 'source_name': 'lung 20wk', 'full_rpkm': 0.0994579, 'exp_rpkm': 0.0995, 'var': 0.001107444, 'project_desc': 'PRJNA270632', '_version_': 1785734389861187595}, 'stomach 10wk': {'id': '1234_Stomach_10wk_PRJNA270632', 'gene': 1234, 'source_name': 'stomach 10wk', 'full_rpkm': 0.0536801, 'exp_rpkm': 0.0537, 'var': 0.000737774, 'project_desc': 'PRJNA270632', '_version_': 1785734389861187596}, 'stomach 16wk': {'id': '1234_Stomach_16wk_PRJNA270632', 'gene': 1234, 'source_name': 'stomach 16wk', 'full_rpkm': 0.0776044, 'exp_rpkm': 0.0776, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389861187597}, 'stomach 18wk': {'id': '1234_Stomach_18wk_PRJNA270632', 'gene': 1234, 'source_name': 'stomach 18wk', 'full_rpkm': 0.132576, 'exp_rpkm': 0.133, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734389861187598}, 'stomach 20wk': {'id': '1234_Stomach_20wk_PRJNA270632', 'gene': 1234, 'source_name': 'stomach 20wk', 'full_rpkm': 0.14934, 'exp_rpkm': 0.149, 'var': 0.00361794, 'project_desc': 'PRJNA270632', '_version_': 1785734389861187599}};
|
||
|
||
|
||
|
||
|
||
window.details_data = {"adrenal 10wk": [{"id": "metadata_9606_SAMN03267754", "gene": 1234, "sample_id": "SAMN03267754", "full_rpkm": 0.0840344, "exp_rpkm": 0.084, "exp_total": 1493, "project_desc": "PRJNA270632", "_version_": 1785734387345653765, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 10wk", "exp_Mcount": 4852.92}], "adrenal 16wk": [{"id": "metadata_9606_SAMN03267755", "gene": 1234, "sample_id": "SAMN03267755", "full_rpkm": 0.0223951, "exp_rpkm": 0.0224, "exp_total": 596, "project_desc": "PRJNA270632", "_version_": 1785734387345653764, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 16wk", "exp_Mcount": 7269.31}], "adrenal 18wk": [{"id": "metadata_9606_SAMN03267761", "gene": 1234, "sample_id": "SAMN03267761", "full_rpkm": 0.0397321, "exp_rpkm": 0.0397, "exp_total": 971, "project_desc": "PRJNA270632", "_version_": 1785734387345653763, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 18wk", "exp_Mcount": 6675.41}], "adrenal 20wk": [{"id": "metadata_9606_SAMN03267762", "gene": 1234, "sample_id": "SAMN03267762", "full_rpkm": 0.0387956, "exp_rpkm": 0.0388, "exp_total": 1074, "project_desc": "PRJNA270632", "_version_": 1785734387345653761, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 20wk", "exp_Mcount": 7561.75}, {"id": "metadata_9606_SAMN03267753", "gene": 1234, "sample_id": "SAMN03267753", "full_rpkm": 0.0339794, "exp_rpkm": 0.034, "exp_total": 827, "project_desc": "PRJNA270632", "_version_": 1785734387345653762, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 20wk", "exp_Mcount": 6647.98}], "heart 10wk": [{"id": "metadata_9606_SAMN03267750", "gene": 1234, "sample_id": "SAMN03267750", "full_rpkm": 0.0519173, "exp_rpkm": 0.0519, "exp_total": 1015, "project_desc": "PRJNA270632", "_version_": 1785734387345653760, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 10wk", "exp_Mcount": 5340.16}], "heart 11wk": [{"id": "metadata_9606_SAMN03267763", "gene": 1234, "sample_id": "SAMN03267763", "full_rpkm": 0.019047, "exp_rpkm": 0.019, "exp_total": 414, "project_desc": "PRJNA270632", "_version_": 1785734387344605210, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 11wk", "exp_Mcount": 5937.09}], "heart 17wk": [{"id": "metadata_9606_SAMN03267757", "gene": 1234, "sample_id": "SAMN03267757", "full_rpkm": 0.013817, "exp_rpkm": 0.0138, "exp_total": 400, "project_desc": "PRJNA270632", "_version_": 1785734387344605209, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 17wk", "exp_Mcount": 7907.66}], "heart 18wk": [{"id": "metadata_9606_SAMN03267751", "gene": 1234, "sample_id": "SAMN03267751", "full_rpkm": 0.0174654, "exp_rpkm": 0.0175, "exp_total": 408, "project_desc": "PRJNA270632", "_version_": 1785734387344605208, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 18wk", "exp_Mcount": 6380.91}], "heart 20wk": [{"id": "metadata_9606_SAMN03267756", "gene": 1234, "sample_id": "SAMN03267756", "full_rpkm": 0.0167315, "exp_rpkm": 0.0167, "exp_total": 665, "project_desc": "PRJNA270632", "_version_": 1785734387344605205, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 20wk", "exp_Mcount": 10856.4}, {"id": "metadata_9606_SAMN03267764", "gene": 1234, "sample_id": "SAMN03267764", "full_rpkm": 0.0535843, "exp_rpkm": 0.0536, "exp_total": 1000, "project_desc": "PRJNA270632", "_version_": 1785734387344605206, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 20wk", "exp_Mcount": 5097.56}, {"id": "metadata_9606_SAMN03267760", "gene": 1234, "sample_id": "SAMN03267760", "full_rpkm": 0.0275699, "exp_rpkm": 0.0276, "exp_total": 605, "project_desc": "PRJNA270632", "_version_": 1785734387344605207, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 20wk", "exp_Mcount": 5994.06}], "intestine 10wk": [{"id": "metadata_9606_SAMN03267752", "gene": 1234, "sample_id": "SAMN03267752", "full_rpkm": 0.0384077, "exp_rpkm": 0.0384, "exp_total": 1098, "project_desc": "PRJNA270632", "_version_": 1785734387344605203, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 10wk", "exp_Mcount": 7808.8}, {"id": "metadata_9606_SAMN03267759", "gene": 1234, "sample_id": "SAMN03267759", "full_rpkm": 0.0165705, "exp_rpkm": 0.0166, "exp_total": 419, "project_desc": "PRJNA270632", "_version_": 1785734387344605204, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 10wk", "exp_Mcount": 6906.84}], "intestine 11wk": [{"id": "metadata_9606_SAMN03267758", "gene": 1234, "sample_id": "SAMN03267758", "full_rpkm": 0.010775, "exp_rpkm": 0.0108, "exp_total": 171, "project_desc": "PRJNA270632", "_version_": 1785734387344605202, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 11wk", "exp_Mcount": 4334.9}], "intestine 15wk": [{"id": "metadata_9606_SAMN03267775", "gene": 1234, "sample_id": "SAMN03267775", "full_rpkm": 0.267697, "exp_rpkm": 0.268, "exp_total": 3901, "project_desc": "PRJNA270632", "_version_": 1785734387344605201, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 15wk", "exp_Mcount": 3980.45}], "intestine 17wk": [{"id": "metadata_9606_SAMN03267782", "gene": 1234, "sample_id": "SAMN03267782", "full_rpkm": 0.109789, "exp_rpkm": 0.11, "exp_total": 3885, "project_desc": "PRJNA270632", "_version_": 1785734387344605200, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 17wk", "exp_Mcount": 9665.65}], "intestine 20wk": [{"id": "metadata_9606_SAMN03267766", "gene": 1234, "sample_id": "SAMN03267766", "full_rpkm": 0.168501, "exp_rpkm": 0.169, "exp_total": 2567, "project_desc": "PRJNA270632", "_version_": 1785734387344605198, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 20wk", "exp_Mcount": 4161.26}, {"id": "metadata_9606_SAMN03267769", "gene": 1234, "sample_id": "SAMN03267769", "full_rpkm": 0.279532, "exp_rpkm": 0.28, "exp_total": 3985, "project_desc": "PRJNA270632", "_version_": 1785734387344605199, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 20wk", "exp_Mcount": 3894.01}], "kidney 10wk": [{"id": "metadata_9606_SAMN03267784", "gene": 1234, "sample_id": "SAMN03267784", "full_rpkm": 0.0771082, "exp_rpkm": 0.0771, "exp_total": 1334, "project_desc": "PRJNA270632", "_version_": 1785734387344605197, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 10wk", "exp_Mcount": 4725.59}], "kidney 16wk": [{"id": "metadata_9606_SAMN03267772", "gene": 1234, "sample_id": "SAMN03267772", "full_rpkm": 0.00979095, "exp_rpkm": 0.00979, "exp_total": 548, "project_desc": "PRJNA270632", "_version_": 1785734387344605196, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 16wk", "exp_Mcount": 15288.2}], "kidney 20wk": [{"id": "metadata_9606_SAMN03267777", "gene": 1234, "sample_id": "SAMN03267777", "full_rpkm": 0.0163676, "exp_rpkm": 0.0164, "exp_total": 616, "project_desc": "PRJNA270632", "_version_": 1785734387344605195, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 20wk", "exp_Mcount": 10280.0}], "lung 10wk": [{"id": "metadata_9606_SAMN03267770", "gene": 1234, "sample_id": "SAMN03267770", "full_rpkm": 0.0321204, "exp_rpkm": 0.0321, "exp_total": 700, "project_desc": "PRJNA270632", "_version_": 1785734387344605193, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 10wk", "exp_Mcount": 5952.75}, {"id": "metadata_9606_SAMN03267767", "gene": 1234, "sample_id": "SAMN03267767", "full_rpkm": 0.00522148, "exp_rpkm": 0.00522, "exp_total": 100, "project_desc": "PRJNA270632", "_version_": 1785734387344605194, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 10wk", "exp_Mcount": 5231.26}], "lung 17wk": [{"id": "metadata_9606_SAMN03267778", "gene": 1234, "sample_id": "SAMN03267778", "full_rpkm": 0.111064, "exp_rpkm": 0.111, "exp_total": 2543, "project_desc": "PRJNA270632", "_version_": 1785734387344605191, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 17wk", "exp_Mcount": 6254.23}, {"id": "metadata_9606_SAMN03267776", "gene": 1234, "sample_id": "SAMN03267776", "full_rpkm": 0.0388928, "exp_rpkm": 0.0389, "exp_total": 533, "project_desc": "PRJNA270632", "_version_": 1785734387344605192, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 17wk", "exp_Mcount": 3743.33}], "lung 20wk": [{"id": "metadata_9606_SAMN03267780", "gene": 1234, "sample_id": "SAMN03267780", "full_rpkm": 0.0661796, "exp_rpkm": 0.0662, "exp_total": 2246, "project_desc": "PRJNA270632", "_version_": 1785734387344605189, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 20wk", "exp_Mcount": 9270.13}, {"id": "metadata_9606_SAMN03267768", "gene": 1234, "sample_id": "SAMN03267768", "full_rpkm": 0.132736, "exp_rpkm": 0.133, "exp_total": 3087, "project_desc": "PRJNA270632", "_version_": 1785734387344605190, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 20wk", "exp_Mcount": 6352.54}], "stomach 10wk": [{"id": "metadata_9606_SAMN03267773", "gene": 1234, "sample_id": "SAMN03267773", "full_rpkm": 0.0265181, "exp_rpkm": 0.0265, "exp_total": 639, "project_desc": "PRJNA270632", "_version_": 1785734387344605187, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 10wk", "exp_Mcount": 6582.02}, {"id": "metadata_9606_SAMN03267779", "gene": 1234, "sample_id": "SAMN03267779", "full_rpkm": 0.0808421, "exp_rpkm": 0.0808, "exp_total": 2141, "project_desc": "PRJNA270632", "_version_": 1785734387344605188, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 10wk", "exp_Mcount": 7234.02}], "stomach 16wk": [{"id": "metadata_9606_SAMN03267774", "gene": 1234, "sample_id": "SAMN03267774", "full_rpkm": 0.0776044, "exp_rpkm": 0.0776, "exp_total": 1767, "project_desc": "PRJNA270632", "_version_": 1785734387344605186, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 16wk", "exp_Mcount": 6219.43}], "stomach 18wk": [{"id": "metadata_9606_SAMN03267771", "gene": 1234, "sample_id": "SAMN03267771", "full_rpkm": 0.132576, "exp_rpkm": 0.133, "exp_total": 2825, "project_desc": "PRJNA270632", "_version_": 1785734387344605185, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 18wk", "exp_Mcount": 5820.42}], "stomach 20wk": [{"id": "metadata_9606_SAMN03267765", "gene": 1234, "sample_id": "SAMN03267765", "full_rpkm": 0.232092, "exp_rpkm": 0.232, "exp_total": 3819, "project_desc": "PRJNA270632", "_version_": 1785734387342508032, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4494.58}, {"id": "metadata_9606_SAMN03267781", "gene": 1234, "sample_id": "SAMN03267781", "full_rpkm": 0.125023, "exp_rpkm": 0.125, "exp_total": 2090, "project_desc": "PRJNA270632", "_version_": 1785734387343556608, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4566.24}, {"id": "metadata_9606_SAMN03267783", "gene": 1234, "sample_id": "SAMN03267783", "full_rpkm": 0.0909062, "exp_rpkm": 0.0909, "exp_total": 1599, "project_desc": "PRJNA270632", "_version_": 1785734387344605184, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4804.58}]}
|
||
window.taxId = 9606
|
||
</script>
|
||
|
||
|
||
<div>
|
||
|
||
|
||
|
||
<select name="p" id="project-selector">
|
||
|
||
|
||
<option value="SRP051249" selected="selected" data-bioproject="PRJNA270632">
|
||
|
||
Tissue-specific circular RNA induction during human fetal development
|
||
|
||
</option>
|
||
|
||
|
||
|
||
<option value="SRP056969" data-bioproject="PRJNA280600">
|
||
|
||
RNA sequencing of total RNA from 20 human tissues
|
||
|
||
|
||
</option>
|
||
|
||
|
||
|
||
<option value="ERP003613" data-bioproject="PRJEB4337">
|
||
|
||
HPA RNA-seq normal tissues
|
||
|
||
|
||
</option>
|
||
|
||
|
||
|
||
</select>
|
||
|
||
|
||
|
||
<ul id="project-summary">
|
||
<li id="project-summary-title">Project title:
|
||
|
||
Tissue-specific circular RNA induction during human fetal development
|
||
|
||
</li>
|
||
|
||
|
||
<li id="project-summary-desc">Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA</li>
|
||
|
||
|
||
|
||
<li id="project-summary-bioprojects">BioProject: <a href="/bioproject/PRJNA270632/">PRJNA270632</a>
|
||
</li>
|
||
|
||
<li id="project-summary-pubs">Publication:
|
||
|
||
|
||
<span><a href="/pubmed/26076956/">PMID 26076956</a></span>
|
||
|
||
</li>
|
||
|
||
|
||
<li id="project-summary-analysis-date">Analysis date: Mon Apr 2 22:54:59 2018</li>
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
<div id="gene-expr-details" class="expression-chart"></div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<script type="text/javascript" src="https://www.gstatic.com/charts/loader.js"></script>
|
||
<script type="text/javascript">
|
||
google.charts.load('current', {
|
||
'packages':[ 'corechart']
|
||
});
|
||
|
||
</script>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-bibliography">
|
||
<section class="rprt-section-header" id="bibliography"><h2 id="header-bibliography"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-bibliography .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Bibliography</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Bibliography" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
|
||
<div class="rprt-section-body" style="">
|
||
<div class="generif-pubmed">
|
||
<h3 id="relatedarticlesinpubmed">
|
||
<a href="#" class="jig-ncbitoggler-open">Related articles in PubMed</a>
|
||
</h3>
|
||
<div class="generefbl-link">
|
||
<ol class="generef-link">
|
||
<li>
|
||
<a href="/pubmed/12915585/" ref="ordinalpos=1&ncbi_uid=1234&link_uid=12915585">Early- and intermediate-stage variants of simian immunodeficiency virus replicate efficiently in cells lacking CCR5.</a>
|
||
<span class="pubmed-auth-date"> Forte S, <em>et al</em>. J Virol, 2003 Sep. PMID 12915585, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC187416/" ref="ordinalpos=0&ncbi_uid=1234&link_uid=PMC187416">Free PMC Article</a></span></span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/24599359/" ref="ordinalpos=2&ncbi_uid=1234&link_uid=24599359">Chemokine receptor 5 Δ32 polymorphism and systemic lupus erythematosus, vasculitis, and primary Sjogren's syndrome. Meta-analysis of possible associations.</a>
|
||
<span class="pubmed-auth-date"> Lee YH, <em>et al</em>. Z Rheumatol, 2014 Nov. PMID 24599359</span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/14636691/" ref="ordinalpos=3&ncbi_uid=1234&link_uid=14636691">More about the Viking hypothesis of origin of the delta32 mutation in the CCR5 gene conferring resistance to HIV-1 infection.</a>
|
||
<span class="pubmed-auth-date"> Lucotte G, <em>et al</em>. Infect Genet Evol, 2003 Nov. PMID 14636691</span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/22537745/" ref="ordinalpos=4&ncbi_uid=1234&link_uid=22537745">Genetic variants in the chemokines and chemokine receptors in Chagas disease.</a>
|
||
<span class="pubmed-auth-date"> Flórez O, <em>et al</em>. Hum Immunol, 2012 Aug. PMID 22537745</span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/14583186/" ref="ordinalpos=5&ncbi_uid=1234&link_uid=14583186">CC-chemokine receptor CCR5-del32 mutation as a modifying pathogenetic factor in type I diabetes.</a>
|
||
<span class="pubmed-auth-date"> Kalev I, <em>et al</em>. J Diabetes Complications, 2003 Nov-Dec. PMID 14583186</span>
|
||
</li>
|
||
</ol>
|
||
<p class="see-all-pm">
|
||
<a href="/pubmed?LinkName=gene_pubmed&from_uid=1234" title="See all 1642 citations in Pubmed">See all (1642) citations in PubMed</a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="generif-pubmed generif">
|
||
<h3 id="generifsgenereferencesintofunctions">
|
||
<a href="#" class="jig-ncbitoggler-open">GeneRIFs: Gene References Into Functions</a>
|
||
</h3>
|
||
<div>
|
||
<a href="/gene/about-generif" class="whatisthis">What's a GeneRIF?</a>
|
||
<div class="generefbl-link">
|
||
<ol class="generef-link">
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/39236430" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=1234&link_uid=39236430">CCL4/CCR5 regulates chondrocyte biology and OA progression.</a>
|
||
<div id="gene-popper1" class="gene-rif-popper">Title: CCL4/CCR5 regulates chondrocyte biology and OA progression.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/38770825" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=1234&link_uid=38770825">The EBI2 receptor is coexpressed with CCR5 in CD4 + T cells and boosts HIV-1 R5 replication.</a>
|
||
<div id="gene-popper2" class="gene-rif-popper">Title: The EBI2 receptor is coexpressed with CCR5 in CD4 + T cells and boosts HIV-1 R5 replication.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/38719543" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=1234&link_uid=38719543">CCR5 and CCL5 in metastatic colorectal cancer.</a>
|
||
<div id="gene-popper3" class="gene-rif-popper">Title: CCR5 and CCL5 in metastatic colorectal cancer.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/38329228" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=1234&link_uid=38329228">Higher CCR5 density on CD4 + T-cells in mothers and infants is associated with increased risk of in-utero HIV-1 transmission.</a>
|
||
<div id="gene-popper4" class="gene-rif-popper">Title: Higher CCR5 density on CD4 + T-cells in mothers and infants is associated with increased risk of in-utero HIV-1 transmission.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/38507500" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=1234&link_uid=38507500">JAK/STAT signaling pathway affects CCR5 expression in human CD4[+] T cells.</a>
|
||
<div id="gene-popper5" class="gene-rif-popper">Title: JAK/STAT signaling pathway affects CCR5 expression in human CD4(+) T cells.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/37690681" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=1234&link_uid=37690681">Multiple mechanisms of self-association of chemokine receptors CXCR4 and CCR5 demonstrated by deep mutagenesis.</a>
|
||
<div id="gene-popper6" class="gene-rif-popper">Title: Multiple mechanisms of self-association of chemokine receptors CXCR4 and CCR5 demonstrated by deep mutagenesis.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/38257729" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=1234&link_uid=38257729">A Pocket Guide to CCR5-Neurotropic Flavivirus Edition.</a>
|
||
<div id="gene-popper7" class="gene-rif-popper">Title: A Pocket Guide to CCR5-Neurotropic Flavivirus Edition.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/37866719" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=1234&link_uid=37866719">The menstrual cycle regulates migratory CD4 T-cell surveillance in the female reproductive tract via CCR5 signaling.</a>
|
||
<div id="gene-popper8" class="gene-rif-popper">Title: The menstrual cycle regulates migratory CD4 T-cell surveillance in the female reproductive tract via CCR5 signaling.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/37489764" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=1234&link_uid=37489764">CCR5 deficiency: Decreased neuronal resilience to oxidative stress and increased risk of vascular dementia.</a>
|
||
<div id="gene-popper9" class="gene-rif-popper">Title: CCR5 deficiency: Decreased neuronal resilience to oxidative stress and increased risk of vascular dementia.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/37984413" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=1234&link_uid=37984413">CCR5 promoter region polymorphisms in systemic lupus erythematosus.</a>
|
||
<div id="gene-popper10" class="gene-rif-popper">Title: CCR5 promoter region polymorphisms in systemic lupus erythematosus.</div>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
<div class="submit-genrif">
|
||
<span>Submit:</span>
|
||
<a href="/gene/submit-generif/?geneId=1234&sym=CCR5&name=C-C motif chemokine receptor 5&org=Homo sapiens">New GeneRIF</a>
|
||
<a href="/RefSeq/update.cgi?geneid=1234&symbol=CCR5;task=fixpub">Correction</a>
|
||
<a href="https://www.ncbi.nlm.nih.gov/gene?db=gene&report=generif&term=1234" class="seeall-generif">See all GeneRIFs (792)</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-phenotypes">
|
||
<section class="rprt-section-header" id="phenotypes">
|
||
<h2 id="header-phenotypes">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-phenotypes .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Phenotypes</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Phenotype" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body info-phenotype">
|
||
<p class="nochild-link">
|
||
<a href="/gtr/tests/?term=CCR5[gene]">Find tests for this gene in the NIH Genetic Testing Registry (GTR)</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/gap/PheGenI?tab=1&gene=1234">Review eQTL and phenotype association data in this region using PheGenI</a>
|
||
</p>
|
||
<div>
|
||
<h3 id="associatedconditions">Associated conditions</h3>
|
||
<table class="jig-ncbigrid gtr-associated-cond">
|
||
<thead>
|
||
<tr>
|
||
<th class="description">Description</th>
|
||
<th>Tests</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/conditions/C1835407" ref="ncbi_uid=1234&link_uid=C1835407">Hepatitis C virus, susceptibility to</a>
|
||
<div class="gtr-associated-cond-extra">
|
||
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C1835407" ref="ncbi_uid=1234&link_uid=C1835407">C1835407</a></span>
|
||
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/609532" ref="ncbi_uid=1234"> 609532</a></span>
|
||
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
|
||
</div>
|
||
</td>
|
||
<td>
|
||
<a href="/gtr/tests/?term=C1835407[DISCUI]&condition=C1835407&compare_labs=1" ref="ncbi_uid=1234">Compare labs</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/conditions/CN077994" ref="ncbi_uid=1234&link_uid=CN077994">Maraviroc response</a>
|
||
<div class="gtr-associated-cond-extra">
|
||
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/CN077994" ref="ncbi_uid=1234&link_uid=CN077994">CN077994</a></span>
|
||
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
|
||
</div>
|
||
</td>
|
||
<td>
|
||
<span class="gtr-na">not available</span>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/conditions/C1836230" ref="ncbi_uid=1234&link_uid=C1836230">Susceptibility to HIV infection</a>
|
||
<div class="gtr-associated-cond-extra">
|
||
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C1836230" ref="ncbi_uid=1234&link_uid=C1836230">C1836230</a></span>
|
||
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/609423" ref="ncbi_uid=1234"> 609423</a></span>
|
||
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
|
||
</div>
|
||
</td>
|
||
<td>
|
||
<a href="/gtr/tests/?term=C1836230[DISCUI]&condition=C1836230&compare_labs=1" ref="ncbi_uid=1234">Compare labs</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/conditions/C2675864" ref="ncbi_uid=1234&link_uid=C2675864">Type 1 diabetes mellitus 22</a>
|
||
<div class="gtr-associated-cond-extra">
|
||
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C2675864" ref="ncbi_uid=1234&link_uid=C2675864">C2675864</a></span>
|
||
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/612522" ref="ncbi_uid=1234"> 612522</a></span>
|
||
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
|
||
</div>
|
||
</td>
|
||
<td>
|
||
<a href="/gtr/tests/?term=C2675864[DISCUI]&condition=C2675864&compare_labs=1" ref="ncbi_uid=1234">Compare labs</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td>
|
||
<a href="/gtr/conditions/C1835867" ref="ncbi_uid=1234&link_uid=C1835867">West Nile virus, susceptibility to</a>
|
||
<div class="gtr-associated-cond-extra">
|
||
<span class="gtr-associated-cond-extra-i">MedGen: <a href="/medgen/C1835867" ref="ncbi_uid=1234&link_uid=C1835867">C1835867</a></span>
|
||
<span class="gtr-associated-cond-extra-i">OMIM: <a href="https://www.ncbi.nlm.nih.gov/omim/610379" ref="ncbi_uid=1234"> 610379</a></span>
|
||
<span class="gtr-associated-cond-extra-i">GeneReviews: <span>Not available</span></span>
|
||
</div>
|
||
</td>
|
||
<td>
|
||
<a href="/gtr/tests/?term=C1835867[DISCUI]&condition=C1835867&compare_labs=1" ref="ncbi_uid=1234">Compare labs</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
<div>
|
||
<h3 id="ebigwascatalog">EBI GWAS Catalog</h3>
|
||
<table class="jig-ncbigrid gtr-associated-cond" data-jigconfig="isPageable: true, pageSize: 10">
|
||
<thead>
|
||
<tr>
|
||
<th class="description">Description</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td>Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/25340798">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/25340798">PubMed</a></span></div></div></div></td>
|
||
</tr>
|
||
<tr>
|
||
<td>Multiple common variants for celiac disease influencing immune gene expression.<div class="gtr-associated-cond-extra"><div class="gtr-associated-cond-extra-c"><span style="color:#000;">EBI GWAS Catalog</span><div><span class="gtr-associated-cond-extra-i"><a href="https://www.ebi.ac.uk/gwas/publications/20190752">EBI GWAS Catalog</a></span><span class="gtr-associated-cond-extra-i"><a href="/pubmed/20190752">PubMed</a></span></div></div></div></td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-variation">
|
||
<section class="rprt-section-header" id="variation">
|
||
<h2 id="header-variation">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Variation</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<p class="nochild-link">
|
||
<a href="/clinvar/?term=CCR5[gene]" ref="log$=recordlinks">See variants in ClinVar</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/dbvar?LinkName=gene_dbvar&from_uid=1234" ref="log$=recordlinks">See studies and variants in dbVar</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/variation/view/?q=1234[geneid]&assm=GCF_000001405.25" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh37.p13)">See Variation Viewer (GRCh37.p13)</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/variation/view/?q=1234[geneid]" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh38)">See Variation Viewer (GRCh38)</a>
|
||
</p>
|
||
<set></set>
|
||
<set></set>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-HIV-1-interactions">
|
||
<section class="rprt-section-header" id="HIV-1-interactions">
|
||
<h2 id="header-HIV-1-interactions">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-HIV-1-interactions .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">HIV-1 interactions</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.HIV1_interactions" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div class="fgrid">
|
||
<h3 id="replicationinteractions">Replication interactions</h3>
|
||
<table summary="replication interactions" class="jig-ncbigrid">
|
||
<thead>
|
||
<tr>
|
||
<th id="hivinter">Interaction</th>
|
||
<th id="hivpub">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="hivinter">HIV/tuberculosis coinfection upregulates CCR5 expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with only tuberculosis)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25924204" href="/pubmed/25924204">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">HIV-1 LAI replication absolutely requires CCR5 and, to a lesser extent, CXCR4 as shown through CRISPR/Cas9 genome editing of each in primary CD4+ T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 27783955" href="/pubmed/27783955">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">HIV-1 replication requires CCR5 expression for infectivity of induced pluripotent stem cells as shown through CRISPR/Cas9 removal of CCR5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26670276" href="/pubmed/26670276">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">HIV-1 replication requires CCR5 expression for infectivity of primary CD4+ T lymphocytes as shown through CRISPR/Cas9 removal of CCR5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25854553" href="/pubmed/25854553">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">HIV-1 infectivity involves C5AR1 in complex with CCR5 on THP-1 and monocyte-derived macrophages as shown through decreased R5-tropic genomic integration in the presence of neutralizing C5aR1 antibody or siRNA knockdown of C5AR1 or hC5a treatment</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26537334" href="/pubmed/26537334">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">Knockdown of chemokine (C-C motif) receptor 5 (CCR5) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25358251,22404213" href="/pubmed/25358251,22404213">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">Knockdown of chemokine (C-C motif) receptor 5 (CCR5) by shRNA inhibits HIV-1 infection in CEM.NKR-CCR5 cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24831610" href="/pubmed/24831610">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
<h3 id="proteininteractions">Protein interactions</h3>
|
||
<table summary="protein interactions" class="jig-ncbigrid">
|
||
<thead>
|
||
<tr>
|
||
<th id="hivprotein">Protein</th>
|
||
<th id="gene-hivprotein">Gene</th>
|
||
<th id="hivinter">Interaction</th>
|
||
<th id="hivpub">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/28876544">Envelope surface glycoprotein gp120</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The CCR5 chemokine receptor is required for the entry of macrophage-tropic HIV-1 into target cells; the HIV-1 gp120-CD4 complex binds CCR5, which inhibits the binding of the natural CCR5 ligands macrophage inflammatory protein (MIP)-1alpha and MIP-1beta</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25880110,25840914,25809903,25730507,25724219,25595802,25387392,25313689,25231990,25193376,25081935,24990163,24957778,24931198,24897520,24862329,24788065,24731927,24657436,24635642,24606688,24586501,24478426,24465884,24461764,24454812,24390333,24387762,24381033,24312168,24312095,24309114,24307580,24215935,24158961,24156625,24149829,24041034,24030490,23884589,23774428,23762317,23696662,23692808,23672855,23606583,23602007,23449229,23446039,23389465,23355876,23350534,23330719,23269796,23229639,23202514,23153179,23143844,23135721,23077246,23043104,23043103,22954962,22908191,22842622,22818780,22811524,22650962,22547820,22520838,22474613,22470838,22447925,22332354,22313935,22297516,22291694,22286875,22219640,22157596,22147802,22147793,22124968,22101471,22069466,22047989,22024519,21994672,21994458,21948112,21926353,21914280,21875413,21859712,21835796,21763507,21760891,21680525,21676905,21663455,21647388,21569409,21555814,21388649,21373976,21362450,21356539,21351426,21349294,21346189,21345957,21330910,21325401,21310296,21295814,21288824,21288812,21284907,21284906,21284902,21284900,21284899,21284403,21248683,21226626,21188555,21165786,21152581,21128884,21118814,21106747,20981786,20969781,20947116,20942936,20923564,20921899,20861743,20856130,20854195,20842205,20810746,20797755,20698725,20678176,20657663,20639728,20622876,20530226,20507591,20494390,20381825,20377425,20299967,20229778,20051874,20041213,20015684,20007245,19837465,19776131,19695656,19692480,19692476,19661992,19625411,19556424,19402700,19401538,19339953,19339951,19279116,19180188,19170639,19144136,19129457,19055831,19020832,19020816,18991615,18977142,18976462,18958626,18925934,18799178,18786994,18691022,18672260,18624812,18619974,18614865,18590744,18588983,18577234,18500445,18490657,18480460,18468560,18453587,18296630,18242797,18203956,18197116,18160142,18090388,18076768,18036244,17977968,17971448,17959679,17947541,17936869,17933721,17933717,17920626,17507486,17507467,17485501,17411375,17346133,17328229,17306322,17201668,17187670,17174449,17151939,17147503,17121788,17116673,17101166,17053352,17041228,17035237,17030448,17010165,16966601,16943294,16934308,16855325,16817962,16796521,16775320,16753228,16721558,16712896,16702010,16686527,16685256,16672549,16515489,16470129,16437164,16386774,16375941,16314403,16309726,16300985,16282475,16157597,16002156,15983047,15972662,15964018,15956589,15890935,15857992,15807900,15784911,15767436,15321703,15279586,15279544,15258189,15215692,15194768,15113926,15045488,15018709,14990703,14967033,14592765,14585219,14517611,14512572,12963807,12960231,12887918,12873765,12873764,12871111,12857973,12845769,12692222,12634405,12610158,12477875,12441808,12429730,12429712,12408990,12392548,12368322,12202222,12190962,12183462,12169668,12163614,12163558,12120995,11967288,11906183,11884536,11878912,11877445,11876757,11861874,11861850,11709091,11698270,11689632,11679153,11602715,11596075,11529558,11517394,11489906,11485305,11468147,11464139,11429110,11427892,11414813,11413305,11397808,11356967,11356961,11342415,11336643,11313374,11312658,11290759,11265761,11264367,11264346,11263244,11238869,11162839,11134270,11118070,11115360,11086073,11069996,11024154,11023526,11005830,10970739,10961858,10938094,10888639,10888615,10882583,10877489,10826481,10823934,10820198,10816381,10775626,10738970,10725362,10644351,10623731,10606089,10602038,10590121,10590105,10585143,10574939,10562492,10559284,10555208,10544150,10527688,10505675,10497246,10487781,10482572,10477718,10449282,10446313,10438870,10413516,10393974,10370370,10357469,10339592,10229873,10200301,10089882,10029247,9971818,9890944,9882373,9882290,9870313,9653051,9636210,9632396,9576954,9576751,9525683,9445013,9420238,9420225,9362541,9359702,9353123,9334377,9261451,9261346,9188565,9184207,9031325,9020356,8995603,8976200,8906796,8906795,8898753,8805353,8674119" href="/pubmed/25880110,25840914,25809903,25730507,25724219,25595802,25387392,25313689,25231990,25193376,25081935,24990163,24957778,24931198,24897520,24862329,24788065,24731927,24657436,24635642,24606688,24586501,24478426,24465884,24461764,24454812,24390333,24387762,24381033,24312168,24312095,24309114,24307580,24215935,24158961,24156625,24149829,24041034,24030490,23884589,23774428,23762317,23696662,23692808,23672855,23606583,23602007,23449229,23446039,23389465,23355876,23350534,23330719,23269796,23229639,23202514,23153179,23143844,23135721,23077246,23043104,23043103,22954962,22908191,22842622,22818780,22811524,22650962,22547820,22520838,22474613,22470838,22447925,22332354,22313935,22297516,22291694,22286875,22219640,22157596,22147802,22147793,22124968,22101471,22069466,22047989,22024519,21994672,21994458,21948112,21926353,21914280,21875413,21859712,21835796,21763507,21760891,21680525,21676905,21663455,21647388,21569409,21555814,21388649,21373976,21362450,21356539,21351426,21349294,21346189,21345957,21330910,21325401,21310296,21295814,21288824,21288812,21284907,21284906,21284902,21284900,21284899,21284403,21248683,21226626,21188555,21165786,21152581,21128884,21118814,21106747,20981786,20969781,20947116,20942936,20923564,20921899,20861743,20856130,20854195,20842205,20810746,20797755,20698725,20678176,20657663,20639728,20622876,20530226,20507591,20494390,20381825,20377425,20299967,20229778,20051874,20041213,20015684,20007245,19837465,19776131,19695656,19692480,19692476,19661992,19625411,19556424,19402700,19401538,19339953,19339951,19279116,19180188,19170639,19144136,19129457,19055831,19020832,19020816,18991615,18977142,18976462,18958626,18925934,18799178,18786994,18691022,18672260,18624812,18619974,18614865,18590744,18588983,18577234,18500445,18490657,18480460,18468560,18453587,18296630,18242797,18203956,18197116,18160142,18090388,18076768,18036244,17977968,17971448,17959679,17947541,17936869,17933721,17933717,17920626,17507486,17507467,17485501,17411375,17346133,17328229,17306322,17201668,17187670,17174449,17151939,17147503,17121788,17116673,17101166,17053352,17041228,17035237,17030448,17010165,16966601,16943294,16934308,16855325,16817962,16796521,16775320,16753228,16721558,16712896,16702010,16686527,16685256,16672549,16515489,16470129,16437164,16386774,16375941,16314403,16309726,16300985,16282475,16157597,16002156,15983047,15972662,15964018,15956589,15890935,15857992,15807900,15784911,15767436,15321703,15279586,15279544,15258189,15215692,15194768,15113926,15045488,15018709,14990703,14967033,14592765,14585219,14517611,14512572,12963807,12960231,12887918,12873765,12873764,12871111,12857973,12845769,12692222,12634405,12610158,12477875,12441808,12429730,12429712,12408990,12392548,12368322,12202222,12190962,12183462,12169668,12163614,12163558,12120995,11967288,11906183,11884536,11878912,11877445,11876757,11861874,11861850,11709091,11698270,11689632,11679153,11602715,11596075,11529558,11517394,11489906,11485305,11468147,11464139,11429110,11427892,11414813,11413305,11397808,11356967,11356961,11342415,11336643,11313374,11312658,11290759,11265761,11264367,11264346,11263244,11238869,11162839,11134270,11118070,11115360,11086073,11069996,11024154,11023526,11005830,10970739,10961858,10938094,10888639,10888615,10882583,10877489,10826481,10823934,10820198,10816381,10775626,10738970,10725362,10644351,10623731,10606089,10602038,10590121,10590105,10585143,10574939,10562492,10559284,10555208,10544150,10527688,10505675,10497246,10487781,10482572,10477718,10449282,10446313,10438870,10413516,10393974,10370370,10357469,10339592,10229873,10200301,10089882,10029247,9971818,9890944,9882373,9882290,9870313,9653051,9636210,9632396,9576954,9576751,9525683,9445013,9420238,9420225,9362541,9359702,9353123,9334377,9261451,9261346,9188565,9184207,9031325,9020356,8995603,8976200,8906796,8906795,8898753,8805353,8674119">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The specific amino acids 298-329 in the V3 loop of HIV-1 gp120 that determine cellular tropism also regulate chemokine coreceptor (CCR5 or CXCR4) preference for cell entry by the virus</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25313689,25265194,24862329,24859049,24763408,24215935,23808984,23758814,23745959,23672855,23606583,23596523,23446039,23369572,23297034,22954962,22876913,22830600,22732432,22728273,22424737,22313935,22292949,22286874,22157596,22047989,21994672,21835796,21760891,21555814,21513481,21288824,21288812,20921899,20381825,20377425,19625411,18815295,18753930,18480460,18160142,18036244,17582634,17507467,17411375,17329448,17328229,17202224,17101166,16966601,16721558,16476981,16378977,15983047,15964018,15890935,15857992,12610158,12490404,12408990,12368322,12202222,12163614,11861850,11153675,11069996,10562492,10544150,10482572,10357469,10200301,9971818,9870313,9653051,9632396,9261451,9184207" href="/pubmed/25313689,25265194,24862329,24859049,24763408,24215935,23808984,23758814,23745959,23672855,23606583,23596523,23446039,23369572,23297034,22954962,22876913,22830600,22732432,22728273,22424737,22313935,22292949,22286874,22157596,22047989,21994672,21835796,21760891,21555814,21513481,21288824,21288812,20921899,20381825,20377425,19625411,18815295,18753930,18480460,18160142,18036244,17582634,17507467,17411375,17329448,17328229,17202224,17101166,16966601,16721558,16476981,16378977,15983047,15964018,15890935,15857992,12610158,12490404,12408990,12368322,12202222,12163614,11861850,11153675,11069996,10562492,10544150,10482572,10357469,10200301,9971818,9870313,9653051,9632396,9261451,9184207">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Env (gp120) V3 loop binds to CXCR4 and CCR5 through in silico analysis</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26859389" href="/pubmed/26859389">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 JR-CSF Env binds CCR5 but is abrogated by the mutation K421D</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24957778" href="/pubmed/24957778">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 JR-CSF Env mutant S142N binds CCR5 with better affinity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24957778" href="/pubmed/24957778">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 binds to CCR5 with decreased affinity when an alanine insertion within the GPG (G310_P311insA) of the gp120 VL3 (resulting from Maraviroc pressure) is present; molecular simulations indicate weakened interaction with CCR5 extracellular loop 2</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26081316" href="/pubmed/26081316">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Env gp120 (JRFL) interacts with the extracellular loop 1 of CCR5 and these interactions are functionally critical; adaptation to murine extracellular loop 1 requires multiple mutations in the crown of gp120s V3 loop</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26114311" href="/pubmed/26114311">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 D197 and T/V200 increase fusion and infection of cells expressing low CD4 by enhancing gp120 binding to CCR5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25797607" href="/pubmed/25797607">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Two-dimensional saturation transfer difference NMR spectroscopy and dynamic filtering studies reveal involvement of residues Y187, F189, W190 and F193 of the second extracellular loop of CCR5 in the interaction with HIV-1 gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25703038" href="/pubmed/25703038">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Antibodies to specific epitopes of HIV-1 gp120 block the interaction of CCR5 with the gp120/CD4 complex, suggesting that a CD4-mediated conformational change in gp120 is required for subsequent binding to CCR5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25888743,25700204,24409525,24243013,24172905,24172896,24172894,23692808,22547820,21994672,21760891,21325401,21152581,20507591,20018238,18815295,18691022,18619974,18490657,18076768,17722977,17507486,17346133,17306322,17053352,16999983,16817962,16702010,16672549,12887918,12477875,11264346,9334377,9261346" href="/pubmed/25888743,25700204,24409525,24243013,24172905,24172896,24172894,23692808,22547820,21994672,21760891,21325401,21152581,20507591,20018238,18815295,18691022,18619974,18490657,18076768,17722977,17507486,17346133,17306322,17053352,16999983,16817962,16702010,16672549,12887918,12477875,11264346,9334377,9261346">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The amino-terminal residues (amino acids 1-25) and three extracellular loops (amino acids 88-102, 168-194, 261-277) of the CCR5 coreceptor are highly involved in its binding to gp120 from macrophage-tropic HIV-1 strains and in CCR5-mediated HIV-1 entry</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25703038,22024519,12183462,11356961,10938094,10823934,10574939,9890944,9882373,9653051,9525683,9445013,9420225" href="/pubmed/25703038,22024519,12183462,11356961,10938094,10823934,10574939,9890944,9882373,9653051,9525683,9445013,9420225">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Anti-CCR5 monoclonal antibodies efficiently prevent HIV-1 infection by inducing receptor dimerization, but not by interfering with HIV-1 gp120 binding to CCR5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25700204,21680525,18691022,10725362" href="/pubmed/25700204,21680525,18691022,10725362">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The binding of HIV-1 gp120 to CCR5 and entry of macrophage-tropic HIV-1 isolates into cells is blocked by CCR5 antagonists or the chemokine RANTES, which interacts with CCR5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25785610,23692808,23229639,22787219,22403408,22286874,21647388,21388649,21188555,20842205,20570309,20018238,19722264,19339953,19129457,18786994,18706447,18588983,18242797,17328229,17053352,15992849,15279544,14990703,12963807,12873765,12873764,12871111,12692222,12689409,11877445,11427892,11313374,11162839,10882583,10820198,10775626,10644351,10393974,9653051,9576751,9420238,9359702,9031325,8976200,8898753" href="/pubmed/25785610,23692808,23229639,22787219,22403408,22286874,21647388,21388649,21188555,20842205,20570309,20018238,19722264,19339953,19129457,18786994,18706447,18588983,18242797,17328229,17053352,15992849,15279544,14990703,12963807,12873765,12873764,12871111,12692222,12689409,11877445,11427892,11313374,11162839,10882583,10820198,10775626,10644351,10393974,9653051,9576751,9420238,9359702,9031325,8976200,8898753">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The coreceptor-binding site in HIV-1 gp120 is centered around an anti-parallel beta-sheet structure 'bridging sheet domain'; mutations in and adjacent to this domain have greater impact on CXCR4-mediated fusion than on CCR5-mediated fusion</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 16631222" href="/pubmed/16631222">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Interaction of HIV-1 gp120 with CCR5 upregulates IL-6 expression in primary human monocyte-derived dendritic cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25008924" href="/pubmed/25008924">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CCR5 expression inhibits HIV-1 gp120-induced LIMK1 activation and cofilin phosphorylation in CD4/CXCR4 expressing 293T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24778234" href="/pubmed/24778234">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CCR5 expression inhibits HIV-1 gp120 binding to CD4/CXCR4 complexes in 293T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24778234" href="/pubmed/24778234">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CCR5 expression inhibits HIV-1 gp120-mediated early actin rearrangement in CD4/CXCR4 expressing 293T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24778234" href="/pubmed/24778234">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120-enhanced CD4/CXCR4 conformation changes are regulated by CCR5 expression in 293T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24778234" href="/pubmed/24778234">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">SMS2, but not SMS1, is involved in enhancement of HIV-1 gp120/gp41-mediated membrane fusion through CD4 receptor and CCR5/CXCR4 coreceptors</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25231990" href="/pubmed/25231990">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 mutant K421D exhibits inefficient entry at low levels of CCR5, while K421D responses dramatically to the entry at high levels of CCR5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24957778" href="/pubmed/24957778">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Negatively charged Asp/Glu at position 322 in the V3 of gp120 and positively charged Arg at position 440 in the C4 of gp120 occur more frequently in CCR5-using strains</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25313689" href="/pubmed/25313689">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">V1, V2, and V3 domains and N-linked glycosylation sites of HIV-1 gp120 confer coreceptor tropism; loss of an N-linked glycosylation site within V3 has a major influence on the virus switching from CCR5 to CXCR4 tropism in a V3 charge-dependent manner</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25313689,24859049,24676404,23672855,23446039,22876913,21676905,21569409,21525208,21513481,21295814,21288824,21288812,20923564,19625411,19339951,18815295,17977968,17971448,17722977,15767436,12368322,11711617,11709091,11689632,11679153,11529558,11390601,11356952,11278567" href="/pubmed/25313689,24859049,24676404,23672855,23446039,22876913,21676905,21569409,21525208,21513481,21295814,21288824,21288812,20923564,19625411,19339951,18815295,17977968,17971448,17722977,15767436,12368322,11711617,11709091,11689632,11679153,11529558,11390601,11356952,11278567">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A single sulfotyrosine residue 14 in CCR5 is recognized by HIV-1 gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24963694,18952441,17901336" href="/pubmed/24963694,18952441,17901336">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">In addition to the V3 loop of HIV-1 gp120, some conserved amino acid residues (117-123, 207, 419-422, and 438-441) are also involved in CCR5 chemokine receptor binding</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24859049,22403408,21284403,21248683,21152581,20969781,20923564,20856130,19692476,18952441,17971448,17901336,16157597,15113926,11278567,10970739,10888615,10826481,10801487,10602038,9632396" href="/pubmed/24859049,22403408,21284403,21248683,21152581,20969781,20923564,20856130,19692476,18952441,17971448,17901336,16157597,15113926,11278567,10970739,10888615,10826481,10801487,10602038,9632396">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 mutations S298N, F313L, and N403S result in weakening gp120's grip on gp41 rather than altering gp120 binding to specific CCR5 sites</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24478426" href="/pubmed/24478426">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Peptides from a library inhibit HIV-1 replication in vitro through blocking of HIV-1 gp120 interaction with the co-receptor CCR5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24149829" href="/pubmed/24149829">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Analysis of the distribution of V3 loop's net charge and flexibility in HIV-1 gp120 shows its selection more positive toward CXCR4 than CCR5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24090041,23808984,22876913,22313935,22292949" href="/pubmed/24090041,23808984,22876913,22313935,22292949">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Interaction of the trimeric gp120 with CCR5 coreceptor triggers dendritic cells (DCs) to migrate between intestinal epithelial cells to sample virions and transfer infection to target cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23606583" href="/pubmed/23606583">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Gelsolin overexpression impairs HIV-1 gp120-induced cortical F-actin reorganization and capping and gp120-mediated CD4-CCR5 and CD4-CXCR4 redistribution in permissive lymphocytes</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23575248" href="/pubmed/23575248">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 binds and signals through CD4, which leads to T cell activation with upregulation of the CXCR5, PD-1, Fas, and FasL expression</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23742646" href="/pubmed/23742646">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120-induced dephosphorylation of KV2.1 and re-localization of KV2.1 on the soma and proximal dendrites results in disruption of the clustered KV2.1 via activation of CCR5/CXCR4 co-receptors or SDF-1 alpha treatment</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24086760" href="/pubmed/24086760">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The V3 loop of brain-derived HIV-1 Env gp120 proteins significantly reduces the contact with N-terminal interface (Tyr10, Asn13, and Tyr14) of CCR5 as compared to lymph-node-derived gp120 proteins</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23077246" href="/pubmed/23077246">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120/41 Envelope proteins form a complex with integrin alpha4beta7 and chemokine receptor CCR5 on the CD4-negative gamma-delta T cell membrane, which leads to activation of the p38-caspase pathway and induces the death of gamma-delta cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21926353" href="/pubmed/21926353">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Antibodies to specific epitopes of the CCR5 or CXCR4 chemokine receptors inhibit the entry of M-tropic, T-tropic, or dual-tropic HIV-1 into target cells by blocking the interaction of the receptors with the HIV-1 gp120/CD4 complex</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21994672,21760891,21680525,21349294,21330910,21152581,18691022,18590744,18490657,18296630,18205925,17507486,17346133,17147503,15321703,11264346,11134270,11069996" href="/pubmed/21994672,21760891,21680525,21349294,21330910,21152581,18691022,18590744,18490657,18296630,18205925,17507486,17346133,17147503,15321703,11264346,11134270,11069996">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Binding of HIV-1 gp120 to CCR5 causes NHERF1-mediated activation of RhoA</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22028271" href="/pubmed/22028271">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Stimulation of cells with HIV-1 gp120 induces the interaction of endogenous CCR5 with NHERF1, which enhances CCR5 internalization</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22028271" href="/pubmed/22028271">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 R5-tropic Env-mediated apoptosis of bystander cells is dependent on both CCR5 expression levels and fusogenic activity of the Env glycoprotein through the mechanism of apoptosis involved caspase-3 activation and mitochondrial depolarization</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21859712" href="/pubmed/21859712">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">NMR studies find the strong interaction of sulfated (CCR5)Tyr14 with (gp120)Arg440</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21763489" href="/pubmed/21763489">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The C-terminal region of CCR5 second extracellular loop (ECL2) comprising Cys178-Lys191 is sufficient for inhibition of HIV-1 entry by R5 and X4 strains. Peptides derived from ECL2 form a complex with HIV-1 gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22403408" href="/pubmed/22403408">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Deaminases APOBEC3F- and APOBEC3G-mediated G-to-A mutations in the V3 region of HIV-1 gp120 lead to the co-receptor switch from R5 to X4 strains</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21573951" href="/pubmed/21573951">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Genistein, tyrosine kinase inhibitor, inhibits cell fusion between macrophages and HIV-1 Env expressing cells. Genistein treatment does not change CD4 or CCR5 surface expression and has no effect on gp120-CD4-CCR5 complex formation</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17030448" href="/pubmed/17030448">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120-induced PI3-kinase activity and calcium mobilization are inhibited by pertussis toxin and blocking antibodies directed against CCR5 and CXCR4, suggesting that this signaling is mediated through these chemokine receptors</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20842205,12960231,12551992" href="/pubmed/20842205,12960231,12551992">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Sulfation of CCR5 by tyrosylprotein sulfotranferase-2 is crucial for mediating interaction with HIV-1 gp120. The pattern and the rate of sulfation for CCR5 depend on the number of amino acids N-terminal of Tyr-3</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19402700" href="/pubmed/19402700">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120-induced Ca(2+) fluxing is CD4 dependent and coreceptor specific, and is mediated by the CCR5 and CXCR4 coreceptors</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20842205,17121788" href="/pubmed/20842205,17121788">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">N362, a potential N-linked glycosylation site immediately N-terminal to CD4-binding site residues in the C3 region of gp120, contributes to fusogenicity of R5 Envs in a strain dependent manner</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18076768" href="/pubmed/18076768">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Individual gp120-CD4 bonds undergo rapid destabilization and this destabilization is significantly enhanced by the coreceptor CCR5, not by CXCR4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18480458" href="/pubmed/18480458">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18453587" href="/pubmed/18453587">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 induces IL-1beta release from macrophages in a time- and concentration-dependent manner through binding to the chemokine receptor CCR5 and coupling to G(i)alpha protein</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18453587" href="/pubmed/18453587">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Introduction of G312V and A204E to multiple subtype A Envs and substitution of G312 and A204 with other residues increase CCR5-dependent entry into pig-tailed macaque lymphocytes</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21325401" href="/pubmed/21325401">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Soluble HIV-1 gp120 protein induces CCR5 downregulation on activated CD4+ T-cells in HIV-infected individuals</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18462992" href="/pubmed/18462992">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 hydrogen bond interactions among transmembrane residues Y108, E283, and Y251, are crucial for HIV-1-gp120/sCD4 complex binding and HIV-1 fusion. HIV-1 gp120 binding to CCR5 disrupts these interhelix hydrogen bond interactions</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18590744" href="/pubmed/18590744">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Maraviroc-resistant gp120 interacts much less efficiently with CCR5 and becomes critically dependent on the V3 loop-CCR5 N terminus and on positively charged elements of the drug-modified CCR5 extracellular loops 1 (His 88) and 2 (His 181)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21345957" href="/pubmed/21345957">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1-induced cell fusion is mediated by multiple regions within both the viral gp120 protein and the CCR5 coreceptor; dual-tropic virus isolates are less tolerant to changes in CCR5 than macrophage-tropic strains that have more restricted coreceptor use</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22908191,20381825,18673537,17686153,16702010,16300985,15258189,12873764,11414813,9334377,9188565,9184207" href="/pubmed/22908191,20381825,18673537,17686153,16702010,16300985,15258189,12873764,11414813,9334377,9188565,9184207">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 from a T-cell-tropic virus causes CD4-dependent antagonism of CXCR4 response to SDF-1alpha, whereas gp120 from macrophage-tropic viruses causes CD4-dependent antagonism of CCR5 response to MIP-1alpha</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21188555,11414813,11413305,9653130" href="/pubmed/21188555,11414813,11413305,9653130">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 induced cell death is inhibited by a CCR5-mediated neuroprotective pathway that involves protein kinase Akt/PKB as an essential component and can be triggered by the CCR5 agonists MIP-1beta and RANTES</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20842205,16841089" href="/pubmed/20842205,16841089">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120-induced neuronal cell death involves p38 mitogen-activated protein kinase; both HIV-1 coreceptors, CCR5 and CXCR4, can mediate HIV-1 gp120-induced neurotoxicity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20842205,16841089" href="/pubmed/20842205,16841089">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The HIV-1 envelope protein gp120 from macrophage-tropic HIV and SIV induces a signal through CCR5 on CD4+ T cells and macrophages, and this gp120-mediated signal transduction induces chemotaxis of T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20842205,12960231,12857973,9353123" href="/pubmed/20842205,12960231,12857973,9353123">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">An adapted primary HIV-1 isolate, ADA, is able to replicate in CD4-negative cells expressing human CCR5; the gp120 glycoprotein of the adapted virus binds CCR5 directly, without prior interaction with CD4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17507486,11238869,10482561,10438870,10339592" href="/pubmed/17507486,11238869,10482561,10438870,10339592">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Membrane fusion inhibitors inhibit HIV-1 infection in T cells by preventing gp120 interaction with CCR5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22044225,17255952,16943294" href="/pubmed/22044225,17255952,16943294">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 and alcohol increase the permeability of the blood-brain barrier (BBB) model, but do not result in a significant synergistic effect. Gp120 permeability involves chemokine receptor CCR5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17207111" href="/pubmed/17207111">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 and gp41-mediated virus-cell fusion is more dependent on viral core maturation for viruses bearing CXCR4-tropic gp120 than for those bearing CCR5-tropic gp120</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 16375941" href="/pubmed/16375941">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The V3 domain of HIV-1 gp120 induces associations between CD4 and CCR5 receptors in cholesterol-rich microenvironments</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 16963439" href="/pubmed/16963439">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Stimulation of human monocyte-derived macrophages with HIV-1 gp120 results in the CCR5-mediated activation of Lyn and the concomitant Lyn-dependent activation of the mitogen-activated protein (MAP) kinase ERK-1/2, which leads to production of TNF-alpha</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 16621960" href="/pubmed/16621960">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A peptide fragment corresponding to the loop between the fifth and sixth transmembrane regions of the CCR5 receptor (amino acids 222-240) can inhibit HIV-1 infection of MT-4 cells, suggesting this region of CCR5 is involved with HIV-1 gp120 binding</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 17210123" href="/pubmed/17210123">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">A synthetic peptide corresponding to amino acid residues 414-434 of HIV-1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 11342415,10438703" href="/pubmed/11342415,10438703">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Chemokines such as MCP-3 and MCP-2 that can compete with high affinity for MIP-1beta binding to CCR5 can also compete for monomeric HIV-1 gp120 binding to CCR5, although with variable potencies</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 10477718" href="/pubmed/10477718">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The chemokine receptor CCR5 is posttranslationally modified by sulfation of its N-terminal tyrosines; sulfated tyrosines contribute to the binding of CCR5 to MIP-1 alpha, MIP-1 beta, and HIV-1 gp120/CD4 complexes and to the ability of HIV-1 to enter cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 12183462,12169668,10497246,10089882" href="/pubmed/12183462,12169668,10497246,10089882">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">N-formyl-methionyl-leucylphenyl-alanine binding to formyl peptide receptor (FPR) results in significant attenuation of cell responses to CCR5 ligands and in inhibition of HIV-1 gp120-mediated fusion and infection of cells expressing CD4, CCR5, and FPR</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 11023526" href="/pubmed/11023526">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 12960231,12857973,10758170" href="/pubmed/12960231,12857973,10758170">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">AGP inhibits the binding of the HIV-1 gp120 consensus V3 domain (V3Cs) and macrophage inflammatory protein-1beta (MIP-1beta) to CCR5 on human monocyte-derived macrophages (MDM)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 11336643" href="/pubmed/11336643">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">CCR5 and CXCR4 coreceptor engagement by HIV-1 gp120 in primary macrophages activates 2 members of the mitogen-activated protein kinase (MAPK) superfamily, c-Jun amino-terminal kinase and p38 MAPK</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 12960231,12857973,11698270,11468147" href="/pubmed/12960231,12857973,11698270,11468147">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 interactions with CXCR4 and CCR5 lead to the cross-desensitization of CCR6 and CCR7; this gp120-induced inhibition is strictly dependent on CXCR4 or CCR5 and lipid rafts but not on CD4 or V(H)3-expressing BCR</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 15972662" href="/pubmed/15972662">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Engagement of the CCR5 and CXCR4 receptors by HIV-1 gp120 induces tyrosine phosphorylation of the protein tyrosine kinase Pyk2</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 12960231,12857973,11698270,9362541" href="/pubmed/12960231,12857973,11698270,9362541">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/9629363">Envelope surface glycoprotein gp160, precursor</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Interaction of the trimeric gp140 with CCR5 coreceptor triggers dendritic cells (DCs) to migrate between intestinal epithelial cells to sample virions and transfer infection to target cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23606583" href="/pubmed/23606583">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/19172954">Envelope transmembrane glycoprotein gp41</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Primary human T cells exposed to HIV gp41 increase CCR5 mRNA expression</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26347747" href="/pubmed/26347747">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">SMS2, but not SMS1, is involved in enhancement of HIV-1 gp120/gp41-mediated membrane fusion through CD4 receptor and CCR5/CXCR4 coreceptors</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25231990" href="/pubmed/25231990">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">The binding of soluble TLR2 to HIV-1 MA, CA, or gp41 inhibits the nuclear translocation of NFKB p65 subunit and downregulates IL-8 and CCR5 expression, leading to inhibition of HIV-1 infection in cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25265071" href="/pubmed/25265071">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120 and gp41 form a transitional complex with the CD4 receptor and CCR5/CXCR4 coreceptors during virus-cell and cell-cell membrane fusion</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25231990,24381033,24371049,24041034,23541872,23043104,23043103,22732432,22297516,22069466,21926353,21760891,21356539,20570309,18991615,18977142,18925934,18500445,18468560,18353949,17686153,15479838,15308751,15258189,15047829,14694113,14505910,12871111" href="/pubmed/25231990,24381033,24371049,24041034,23541872,23043104,23043103,22732432,22297516,22069466,21926353,21760891,21356539,20570309,18991615,18977142,18925934,18500445,18468560,18353949,17686153,15479838,15308751,15258189,15047829,14694113,14505910,12871111">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp120/41 Envelope proteins form a complex with integrin alpha4beta7 and chemokine receptor CCR5 on the CD4-negative gamma-delta T cell membrane, which leads to activation of the p38-caspase pathway and induces the death of gamma-delta cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21926353" href="/pubmed/21926353">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 R5-tropic Env-mediated apoptosis of bystander cells is dependent on both CCR5 expression levels and fusogenic activity of the Env glycoprotein through the mechanism of apoptosis involved caspase-3 activation and mitochondrial depolarization</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21859712" href="/pubmed/21859712">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Sequences in the gp41 transmembrane (TM) can modulate coreceptor specificity and that Env sequences other than that of V3 may facilitate efficient CXCR4-mediated entry</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18353956" href="/pubmed/18353956">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Peptide P5 (residues 628-683), comprising the entire membrane proximal region of HIV-1 gp41 and its calcium-binding site, inhibits HIV-1 envelope mediated cell-cell fusion and infection of PBMCs by both X4- and R5-tropic HIV-1 strains</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 18925934" href="/pubmed/18925934">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">RANTES, MIP-1beta, and anti-CD4 antibodies inhibit CCR5-dependent cell-cell fusion mediated by HIV-1 gp120 and gp41 from macrophage-tropic isolates</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 9256481" href="/pubmed/9256481">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 10807185" href="/pubmed/10807185">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155971">env</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 gp41 activates innate host immune cells through FPRL1, and the activation of FPRL1 by gp41 further induces the phosphorylation of the chemokine receptor CCR5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 10872839" href="/pubmed/10872839">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/28872818">Nef</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef expression from unintegrated HIV-1 DNA downregulates the surface levels of CD4, CCR5, and CXCR4 on T-lymphocytes and monocytes</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25807049,22808111,21696586,20465832" href="/pubmed/25807049,22808111,21696586,20465832">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Nef downregulates cell-surface levels of CCR5 in CHO cells expressing human CCR5; the Nef-induced downregulation of CCR5 is as efficient as the downregulation induced by the natural beta-chemokine ligand RANTES</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24489825,22175768,22103834,22103833,20594957,19149577,18462992,15854903" href="/pubmed/24489825,22175768,22103834,22103833,20594957,19149577,18462992,15854903">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/156110">nef</a>
|
||
</td>
|
||
<td headers="hivinter">SH3 (PxxP motif) and PACS (E4) interaction surfaces as well as the myristoylation site (G2) in HIV-1 Nef are required for Nef-mediated downregulation of CCR5</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 15854903" href="/pubmed/15854903">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/9629358">Tat</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat upregulates CCR5 expression on monocytes/macrophages but not on lymphocytes, indicating a role for Tat in HIV-1 pathogenesis and in promoting the infection of monocytes/macrophages.</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23842123,19864932,16179731,15629079,15586413,10453044,9765440" href="/pubmed/23842123,19864932,16179731,15629079,15586413,10453044,9765440">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">Results from the treatment of microglia with HIV-1 Tat suggest downregulation of CCR5 mRNA expression by HIV-1 Tat, however this was deemed to not be significant</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 16179731,10751368" href="/pubmed/16179731,10751368">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155871">tat</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Tat is associated with upregulation of CCR5 and MIP-1alpha expression in nodular lesions found in HIV encephalopathy and progressive multifocal leukoencephalopathy (PML), indicating a role for Tat in HIV-1 pathogenesis</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 10602409" href="/pubmed/10602409">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/28872817">Vpr</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155807">vpr</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Vpr depletes regulatory CD4+ T cells and enhances HIV-1 replication in a CCR5 coreceptor-dependent manner</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24339781" href="/pubmed/24339781">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/19172948">capsid</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">Primary human T cells exposed to HIV CA (p24) increase CCR5 mRNA expression</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26347747" href="/pubmed/26347747">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">Herpes simplex virus type 2-Infected monocyte-derived dendritic cells (MDDCs) produce TNF-alpha, which binds to its receptor TNF-R1 and upregulates the expression of CCR5 on cell surface, leading to enhance HIV-1 p24 release from MDDCs</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25840914" href="/pubmed/25840914">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">The binding of soluble TLR2 to HIV-1 MA, CA, or gp41 inhibits the nuclear translocation of NFKB p65 subunit and downregulates IL-8 and CCR5 expression, leading to inhibition of HIV-1 infection in cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25265071" href="/pubmed/25265071">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/28876542">matrix</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">Exposure of primary human T cells to HIV MA (p17) increases CCR5 mRNA expression</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26347747" href="/pubmed/26347747">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">The binding of soluble TLR2 to HIV-1 MA, CA, or gp41 inhibits the nuclear translocation of NFKB p65 subunit and downregulates IL-8 and CCR5 expression, leading to inhibition of HIV-1 infection in cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25265071" href="/pubmed/25265071">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
<p class="withnote">
|
||
<a class="note" href="/genome/viruses/retroviruses/hiv-1/interactions/">Go to the HIV-1, Human Interaction Database </a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-pathways">
|
||
<section class="rprt-section-header" id="pathways">
|
||
<h2 id="header-pathways">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-pathways .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Pathways from PubChem</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<ul class="geneinfo-subsec infopathway">
|
||
<iframe title="Pathways in which the gene target is involved" class="pubchem-widget" scrolling="no" src="https://pubchem.ncbi.nlm.nih.gov/gene/1234#section=Pathways&embed=true&hide_all_headings=true&page_size=25" style="border: 0; width: 100%;"></iframe>
|
||
<script type="text/javascript" src="https://pubchem.ncbi.nlm.nih.gov/pcfe/libs/iframeResizer.min.js"></script>
|
||
<script type="text/javascript">iFrameResize({log: false, checkOrigin: false}, '.pubchem-widget')</script>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-interactions">
|
||
<section class="rprt-section-header" id="interactions">
|
||
<h2 id="header-interactions">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-interactions .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Interactions</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Interactions" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<table summary="Gene Interaction" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/1234/data/interaction/',webserviceParams: 'p$l=Ajax&p$debugoutput=off', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th id="inter-prod">Products</th>
|
||
<th id="inter-interactant">Interactant</th>
|
||
<th id="inter-otherGene">Other Gene</th>
|
||
<th id="inter-compl">Complex</th>
|
||
<th id="inter-source">Source</th>
|
||
<th id="inter-pubs">Pubs</th>
|
||
<th id="inter-desc">Description</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody></tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-general-gene-info">
|
||
<section class="rprt-section-header" id="general-gene-info">
|
||
<h2 id="header-general-gene-info">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">General gene information</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
|
||
<div class="rprt-section-body" style="">
|
||
<div id="gene-markers">
|
||
<h3 id="markers">
|
||
<a class="jig-ncbitoggler">Markers</a>
|
||
</h3>
|
||
<div>
|
||
<ul class="marker odd">
|
||
<li class="marker">D3S4504 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=474434%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=1234&link_uid=474434">UniSTS:474434</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">RH65248 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=88902%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=1234&link_uid=88902">UniSTS:88902</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">STS-X91492 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=43626%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=1234&link_uid=43626">UniSTS:43626</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">CCR5_4 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=276171%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=1234&link_uid=276171">UniSTS:276171</a></li></ul></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div></div>
|
||
|
||
<div class="infosec">
|
||
<h3 id="homology">
|
||
<a class="jig-ncbitoggler-open">Homology</a>
|
||
</h3>
|
||
<ul class="geneinfo-subsec">
|
||
<li>
|
||
<a href="/gene/1234/ortholog/" id="ncbi-ortholog-link">NCBI Orthologs</a>
|
||
</li>
|
||
<a href="https://www.orthodb.org/?ncbi=1234" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=8178" target="_blank">
|
||
Orthologs from OrthoDB
|
||
</a>
|
||
</ul>
|
||
</div>
|
||
|
||
<!--<component id="Gene_InfoPathway"/>-->
|
||
|
||
<div class="infosec info-comment" id="info-comment">
|
||
<h3 id="CloneNames">
|
||
<a class="jig-ncbitoggler-open">Clone Names</a>
|
||
</h3>
|
||
<ul class="geneinfo-subsec">
|
||
<li>FLJ78003 </li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="gene-ontology infosec">
|
||
<h3 id="gene-ontology">
|
||
<a class="jig-ncbitoggler-open">
|
||
<span>Gene Ontology</span>
|
||
</a>
|
||
<a target="_blank" href="http://www.ebi.ac.uk/GOA" class="g-ontology-src" title="Provided by GOA">Provided by GOA</a>
|
||
</h3>
|
||
<div class="ontology-tables">
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Function</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0019957">enables C-C chemokine binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-1-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/8699119,10383387,10679098" target="_blank" title="PubMed ID 8699119,10383387,10679098" ref="ordinalpos=1&ncbi_uid=1234&link_uid=8699119,10383387,10679098">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0016493">enables C-C chemokine receptor activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-2-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0016493">enables C-C chemokine receptor activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-3-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/8639485,10383387,11278962" target="_blank" title="PubMed ID 8639485,10383387,11278962" ref="ordinalpos=1&ncbi_uid=1234&link_uid=8639485,10383387,11278962">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0016493">enables C-C chemokine receptor activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> NAS</a>
|
||
<div id="evidence-code-4-0" class="ecode">Non-traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/8639485" target="_blank" title="PubMed ID 8639485" ref="ordinalpos=1&ncbi_uid=1234&link_uid=8639485">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0003779">enables actin binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-5-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/12421915" target="_blank" title="PubMed ID 12421915" ref="ordinalpos=1&ncbi_uid=1234&link_uid=12421915">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0071791">enables chemokine (C-C motif) ligand 5 binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-6-0" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0071791">enables chemokine (C-C motif) ligand 5 binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-7-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/8699119" target="_blank" title="PubMed ID 8699119" ref="ordinalpos=1&ncbi_uid=1234&link_uid=8699119">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0004950">enables chemokine receptor activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-8-0" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/10201901" target="_blank" title="PubMed ID 10201901" ref="ordinalpos=1&ncbi_uid=1234&link_uid=10201901">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0015026">enables coreceptor activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-9-0" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/10469138" target="_blank" title="PubMed ID 10469138" ref="ordinalpos=1&ncbi_uid=1234&link_uid=10469138">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0042802">enables identical protein binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-10-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/18230715,18632580,23121557" target="_blank" title="PubMed ID 18230715,18632580,23121557" ref="ordinalpos=1&ncbi_uid=1234&link_uid=18230715,18632580,23121557">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0004435">enables phosphatidylinositol phospholipase C activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-11-0" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/8663314" target="_blank" title="PubMed ID 8663314" ref="ordinalpos=1&ncbi_uid=1234&link_uid=8663314">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005515">enables protein binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-12-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/10816381,12421915,15001559,15660419,18230715,18632580,23235831,23480650,23597562,24405750,28381538,30542158,32296183" target="_blank" title="PubMed ID 10816381,12421915,15001559,15660419,18230715,18632580,23235831,23480650,23597562,24405750,28381538,30542158,32296183" ref="ordinalpos=1&ncbi_uid=1234&link_uid=10816381,12421915,15001559,15660419,18230715,18632580,23235831,23480650,23597562,24405750,28381538,30542158,32296183">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0001618">enables virus receptor activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-13-0" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Process</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0007186">involved_in G protein-coupled receptor signaling pathway</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-1-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19523456" target="_blank" title="PubMed ID 19523456" ref="ordinalpos=1&ncbi_uid=1234&link_uid=19523456">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0000165">involved_in MAPK cascade</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEP</a>
|
||
<div id="evidence-code-2-1" class="ecode">Inferred from Expression Pattern<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/12032188" target="_blank" title="PubMed ID 12032188" ref="ordinalpos=1&ncbi_uid=1234&link_uid=12032188">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0006915">involved_in apoptotic process</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-3-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0006816">involved_in calcium ion transport</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-4-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/8699119" target="_blank" title="PubMed ID 8699119" ref="ordinalpos=1&ncbi_uid=1234&link_uid=8699119">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0019722">involved_in calcium-mediated signaling</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-5-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0019722">involved_in calcium-mediated signaling</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-6-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/10679098,19523456" target="_blank" title="PubMed ID 10679098,19523456" ref="ordinalpos=1&ncbi_uid=1234&link_uid=10679098,19523456">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0060326">involved_in cell chemotaxis</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-7-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0007166">involved_in cell surface receptor signaling pathway</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-8-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/8639485" target="_blank" title="PubMed ID 8639485" ref="ordinalpos=1&ncbi_uid=1234&link_uid=8639485">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0007267">involved_in cell-cell signaling</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-9-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/10679098" target="_blank" title="PubMed ID 10679098" ref="ordinalpos=1&ncbi_uid=1234&link_uid=10679098">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0006968">involved_in cellular defense response</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-10-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-10-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/10201901" target="_blank" title="PubMed ID 10201901" ref="ordinalpos=1&ncbi_uid=1234&link_uid=10201901">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0071222">involved_in cellular response to lipopolysaccharide</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-11-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEP</a>
|
||
<div id="evidence-code-11-1" class="ecode">Inferred from Expression Pattern<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/10679098" target="_blank" title="PubMed ID 10679098" ref="ordinalpos=1&ncbi_uid=1234&link_uid=10679098">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0070098">involved_in chemokine-mediated signaling pathway</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-12-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-12-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0006935">involved_in chemotaxis</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-13-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-13-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/10741397" target="_blank" title="PubMed ID 10741397" ref="ordinalpos=1&ncbi_uid=1234&link_uid=10741397">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0002407">involved_in dendritic cell chemotaxis</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-14-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-14-1" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/16621978" target="_blank" title="PubMed ID 16621978" ref="ordinalpos=1&ncbi_uid=1234&link_uid=16621978">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0006955">involved_in immune response</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-15-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-15-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0006954">involved_in inflammatory response</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-16-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-16-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:2000110">involved_in negative regulation of macrophage apoptotic process</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-17-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-17-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0007204">involved_in positive regulation of cytosolic calcium ion concentration</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-18-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-18-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0014808">involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-19-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-19-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19523456" target="_blank" title="PubMed ID 19523456" ref="ordinalpos=1&ncbi_uid=1234&link_uid=19523456">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0070723">involved_in response to cholesterol</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-20-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IMP</a>
|
||
<div id="evidence-code-20-1" class="ecode">Inferred from Mutant Phenotype<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/19523456" target="_blank" title="PubMed ID 19523456" ref="ordinalpos=1&ncbi_uid=1234&link_uid=19523456">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0023052">involved_in signaling</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-21-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEP</a>
|
||
<div id="evidence-code-21-1" class="ecode">Inferred from Expression Pattern<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/12032188" target="_blank" title="PubMed ID 12032188" ref="ordinalpos=1&ncbi_uid=1234&link_uid=12032188">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0046718">involved_in symbiont entry into host cell</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-22-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IEA</a>
|
||
<div id="evidence-code-22-1" class="ecode">Inferred from Electronic Annotation<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-config="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Component</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0009986">is_active_in cell surface</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-1-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/29739880" target="_blank" title="PubMed ID 29739880" ref="ordinalpos=1&ncbi_uid=1234&link_uid=29739880">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0009986">located_in cell surface</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-2-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/10521508" target="_blank" title="PubMed ID 10521508" ref="ordinalpos=1&ncbi_uid=1234&link_uid=10521508">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005737">is_active_in cytoplasm</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-3-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005768">located_in endosome</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-4-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/10679098" target="_blank" title="PubMed ID 10679098" ref="ordinalpos=1&ncbi_uid=1234&link_uid=10679098">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0009897">is_active_in external side of plasma membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-5-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0009897">located_in external side of plasma membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-6-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/10383387,10679098,11278962,19523456" target="_blank" title="PubMed ID 10383387,10679098,11278962,19523456" ref="ordinalpos=1&ncbi_uid=1234&link_uid=10383387,10679098,11278962,19523456">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005886">located_in plasma membrane</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-7-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-general-protein-info">
|
||
<section class="rprt-section-header" id="general-protein-info">
|
||
<h2 id="header-general-protein-info">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-protein-info .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">General protein information</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.General_Protein_Information" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<dl>
|
||
<dt>Preferred Names</dt>
|
||
<dd>C-C chemokine receptor type 5</dd>
|
||
</dl>
|
||
<dl>
|
||
<dt>Names</dt>
|
||
<dd>C-C motif chemokine receptor 5 A159A</dd>
|
||
<dd>HIV-1 fusion coreceptor</dd>
|
||
<dd>chemokine (C-C motif) receptor 5</dd>
|
||
<dd>chemokine receptor CCR5</dd>
|
||
<dd>chemokine recptor CCR5 Delta32</dd>
|
||
<dd>chemr13</dd>
|
||
<dd>mutant C-C motif chemokine receptor</dd>
|
||
</dl>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-reference-sequences">
|
||
<section class="rprt-section-header" id="reference-sequences">
|
||
<h2 id="header-reference-sequences">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-reference-sequences .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">NCBI Reference Sequences (RefSeq)</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.NCBI_Reference_Sequences_RefS" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<p>
|
||
<span class="new-icon">NEW</span>
|
||
<strong>Try the new <a href="/datasets/tables/genes/?table_type=transcripts&ids=1234&utm_source=gene&utm_medium=referral&utm_campaign=refseq" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report." data-ga-category="refseq" data-ga-action="click_datasets_link" data-ga-label="transcript_table">Transcript table</a></strong>
|
||
</p>
|
||
<h3 class="genomerefseqs gene_std_toggler" id="refseqset-independent">
|
||
<a class="jig-ncbitoggler-open">RefSeqs maintained independently of Annotated
|
||
Genomes</a>
|
||
</h3>
|
||
<div class="genomerefseqs_slave">
|
||
<p class="desc"> These reference sequences exist independently of genome builds. <a href="#refseq-expl" id="expl-refseg">Explain</a></p>
|
||
<p id="refseq-expl"> These reference sequences are curated independently of the genome
|
||
annotation cycle, so their versions may not match the RefSeq versions in the current
|
||
genome build. Identify version mismatches by comparing the version of the RefSeq in
|
||
this section to the one reported in <a href="#geneGenomic regions, transcripts, and products">Genomic regions,
|
||
transcripts, and products</a> above. </p>
|
||
<h4 id="genomic-p113686960">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NG_012637.1 RefSeqGene</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>5805..11065</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NG_012637.1?from=5805&to=11065&report=genbank" ref="ordinalpos=1&ncbi_uid=1234&link_uid=NG_012637.1?from=5805&to=11065&report=genbank">GenBank</a>, <a href="/nuccore/NG_012637.1?from=5805&to=11065&report=fasta" ref="ordinalpos=1&ncbi_uid=1234&link_uid=NG_012637.1?from=5805&to=11065&report=fasta">FASTA</a>, <a href="/nuccore/NG_012637.1?from=5015&to=11853&report=graph&content=5" ref="ordinalpos=1&ncbi_uid=1234&link_uid=NG_012637.1?from=5015&to=11853&report=graph&content=5">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
<h4 id="mrnaandproteins-p119884816">mRNA and Protein(s) </h4>
|
||
<ol>
|
||
<li>
|
||
<p><a href="/nuccore/NM_000579.4">NM_000579.4</a> → <a href="/protein/NP_000570.1">NP_000570.1</a> C-C chemokine receptor type 5</p>
|
||
<p>
|
||
<a href="/ipg/NP_000570.1/" ref="ncbi_uid=1234">See identical proteins and their annotated locations for NP_000570.1</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (A) represents the longer transcript. Both variants encode the same protein.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC098613, BC038398, DA818906, U54994">AC098613, BC038398, DA818906, U54994</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS2739.1">CCDS2739.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/Swiss-Prot</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/O14692" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14692</a>, <a href="https://www.uniprot.org/uniprot/O14693" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14693</a>, <a href="https://www.uniprot.org/uniprot/O14695" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14695</a>, <a href="https://www.uniprot.org/uniprot/O14696" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14696</a>, <a href="https://www.uniprot.org/uniprot/O14697" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14697</a>, <a href="https://www.uniprot.org/uniprot/O14698" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14698</a>, <a href="https://www.uniprot.org/uniprot/O14699" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14699</a>, <a href="https://www.uniprot.org/uniprot/O14700" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14700</a>, <a href="https://www.uniprot.org/uniprot/O14701" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14701</a>, <a href="https://www.uniprot.org/uniprot/O14702" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14702</a>, <a href="https://www.uniprot.org/uniprot/O14703" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14703</a>, <a href="https://www.uniprot.org/uniprot/O14704" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14704</a>, <a href="https://www.uniprot.org/uniprot/O14705" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14705</a>, <a href="https://www.uniprot.org/uniprot/O14706" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14706</a>, <a href="https://www.uniprot.org/uniprot/O14707" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14707</a>, <a href="https://www.uniprot.org/uniprot/O14708" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14708</a>, <a href="https://www.uniprot.org/uniprot/O15538" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O15538</a>, <a href="https://www.uniprot.org/uniprot/P51681" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">P51681</a>, <a href="https://www.uniprot.org/uniprot/Q9UPA4" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">Q9UPA4</a></dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/A0A089G3J8" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G3J8</a>, <a href="https://www.uniprot.org/uniprot/A0A089G3L9" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G3L9</a>, <a href="https://www.uniprot.org/uniprot/A0A089G3M1" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G3M1</a>, <a href="https://www.uniprot.org/uniprot/A0A089G3N1" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G3N1</a>, <a href="https://www.uniprot.org/uniprot/A0A089G3P4" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G3P4</a>, <a href="https://www.uniprot.org/uniprot/A0A089G5N2" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G5N2</a>, <a href="https://www.uniprot.org/uniprot/A0A089G6S3" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G6S3</a>, <a href="https://www.uniprot.org/uniprot/A0A089G7J6" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G7J6</a>, <a href="https://www.uniprot.org/uniprot/A0A089H983" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089H983</a>, <a href="https://www.uniprot.org/uniprot/A0A089H987" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089H987</a>, <a href="https://www.uniprot.org/uniprot/B0EX00" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">B0EX00</a>, <a href="https://www.uniprot.org/uniprot/B0EX01" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">B0EX01</a>, <a href="https://www.uniprot.org/uniprot/B2KIU0" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">B2KIU0</a>, <a href="https://www.uniprot.org/uniprot/B2KIU1" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">B2KIU1</a>, <a href="https://www.uniprot.org/uniprot/B2KKJ9" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">B2KKJ9</a>, <a href="https://www.uniprot.org/uniprot/H9MHP3" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">H9MHP3</a>, <a href="https://www.uniprot.org/uniprot/H9MHP6" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">H9MHP6</a>, <a href="https://www.uniprot.org/uniprot/H9MHP8" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">H9MHP8</a>, <a href="https://www.uniprot.org/uniprot/H9MHP9" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">H9MHP9</a>, <a href="https://www.uniprot.org/uniprot/L7S2Y4" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">L7S2Y4</a>, <a href="https://www.uniprot.org/uniprot/Q38L21" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">Q38L21</a>, <a href="https://www.uniprot.org/uniprot/Q3L3Q6" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">Q3L3Q6</a>, <a href="https://www.uniprot.org/uniprot/Q5EKM9" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">Q5EKM9</a>, <a href="https://www.uniprot.org/uniprot/Q5QIN9" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">Q5QIN9</a>, <a href="https://www.uniprot.org/uniprot/Q5QIP1" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">Q5QIP1</a></dd>
|
||
<dt class="clear"> Conserved Domains (1) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_000570.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=341338">cd15184</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">31</span> → <span class="cddto">308</span></dt>
|
||
<dd class="clearfix"> 7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001100168.2">NM_001100168.2</a> → <a href="/protein/NP_001093638.1">NP_001093638.1</a> C-C chemokine receptor type 5</p>
|
||
<p>
|
||
<a href="/ipg/NP_001093638.1/" ref="ncbi_uid=1234">See identical proteins and their annotated locations for NP_001093638.1</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (B) differs in the 5' UTR compared to variant A. Both variants encode the same protein.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC098613, BC038398, DA818906, U54994">AC098613, BC038398, DA818906, U54994</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS2739.1">CCDS2739.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/Swiss-Prot</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/O14692" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14692</a>, <a href="https://www.uniprot.org/uniprot/O14693" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14693</a>, <a href="https://www.uniprot.org/uniprot/O14695" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14695</a>, <a href="https://www.uniprot.org/uniprot/O14696" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14696</a>, <a href="https://www.uniprot.org/uniprot/O14697" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14697</a>, <a href="https://www.uniprot.org/uniprot/O14698" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14698</a>, <a href="https://www.uniprot.org/uniprot/O14699" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14699</a>, <a href="https://www.uniprot.org/uniprot/O14700" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14700</a>, <a href="https://www.uniprot.org/uniprot/O14701" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14701</a>, <a href="https://www.uniprot.org/uniprot/O14702" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14702</a>, <a href="https://www.uniprot.org/uniprot/O14703" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14703</a>, <a href="https://www.uniprot.org/uniprot/O14704" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14704</a>, <a href="https://www.uniprot.org/uniprot/O14705" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14705</a>, <a href="https://www.uniprot.org/uniprot/O14706" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14706</a>, <a href="https://www.uniprot.org/uniprot/O14707" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14707</a>, <a href="https://www.uniprot.org/uniprot/O14708" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14708</a>, <a href="https://www.uniprot.org/uniprot/O15538" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O15538</a>, <a href="https://www.uniprot.org/uniprot/P51681" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">P51681</a>, <a href="https://www.uniprot.org/uniprot/Q9UPA4" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">Q9UPA4</a></dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/A0A089G3J8" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G3J8</a>, <a href="https://www.uniprot.org/uniprot/A0A089G3L9" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G3L9</a>, <a href="https://www.uniprot.org/uniprot/A0A089G3M1" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G3M1</a>, <a href="https://www.uniprot.org/uniprot/A0A089G3N1" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G3N1</a>, <a href="https://www.uniprot.org/uniprot/A0A089G3P4" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G3P4</a>, <a href="https://www.uniprot.org/uniprot/A0A089G5N2" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G5N2</a>, <a href="https://www.uniprot.org/uniprot/A0A089G6S3" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G6S3</a>, <a href="https://www.uniprot.org/uniprot/A0A089G7J6" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G7J6</a>, <a href="https://www.uniprot.org/uniprot/A0A089H983" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089H983</a>, <a href="https://www.uniprot.org/uniprot/A0A089H987" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089H987</a>, <a href="https://www.uniprot.org/uniprot/B0EX00" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">B0EX00</a>, <a href="https://www.uniprot.org/uniprot/B0EX01" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">B0EX01</a>, <a href="https://www.uniprot.org/uniprot/B2KIU0" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">B2KIU0</a>, <a href="https://www.uniprot.org/uniprot/B2KIU1" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">B2KIU1</a>, <a href="https://www.uniprot.org/uniprot/B2KKJ9" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">B2KKJ9</a>, <a href="https://www.uniprot.org/uniprot/H9MHP3" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">H9MHP3</a>, <a href="https://www.uniprot.org/uniprot/H9MHP6" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">H9MHP6</a>, <a href="https://www.uniprot.org/uniprot/H9MHP8" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">H9MHP8</a>, <a href="https://www.uniprot.org/uniprot/H9MHP9" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">H9MHP9</a>, <a href="https://www.uniprot.org/uniprot/L7S2Y4" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">L7S2Y4</a>, <a href="https://www.uniprot.org/uniprot/Q38L21" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">Q38L21</a>, <a href="https://www.uniprot.org/uniprot/Q3L3Q6" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">Q3L3Q6</a>, <a href="https://www.uniprot.org/uniprot/Q5EKM9" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">Q5EKM9</a>, <a href="https://www.uniprot.org/uniprot/Q5QIN9" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">Q5QIN9</a>, <a href="https://www.uniprot.org/uniprot/Q5QIP1" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">Q5QIP1</a></dd>
|
||
<dt class="clear"> Conserved Domains (1) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001093638.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=341338">cd15184</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">31</span> → <span class="cddto">308</span></dt>
|
||
<dd class="clearfix"> 7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001394783.1">NM_001394783.1</a> → <a href="/protein/NP_001381712.1">NP_001381712.1</a> C-C chemokine receptor type 5</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: REVIEWED</p>
|
||
<dl>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AC098613">AC098613</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS2739.1">CCDS2739.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/Swiss-Prot</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/O14692" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14692</a>, <a href="https://www.uniprot.org/uniprot/O14693" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14693</a>, <a href="https://www.uniprot.org/uniprot/O14695" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14695</a>, <a href="https://www.uniprot.org/uniprot/O14696" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14696</a>, <a href="https://www.uniprot.org/uniprot/O14697" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14697</a>, <a href="https://www.uniprot.org/uniprot/O14698" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14698</a>, <a href="https://www.uniprot.org/uniprot/O14699" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14699</a>, <a href="https://www.uniprot.org/uniprot/O14700" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14700</a>, <a href="https://www.uniprot.org/uniprot/O14701" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14701</a>, <a href="https://www.uniprot.org/uniprot/O14702" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14702</a>, <a href="https://www.uniprot.org/uniprot/O14703" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14703</a>, <a href="https://www.uniprot.org/uniprot/O14704" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14704</a>, <a href="https://www.uniprot.org/uniprot/O14705" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14705</a>, <a href="https://www.uniprot.org/uniprot/O14706" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14706</a>, <a href="https://www.uniprot.org/uniprot/O14707" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14707</a>, <a href="https://www.uniprot.org/uniprot/O14708" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O14708</a>, <a href="https://www.uniprot.org/uniprot/O15538" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">O15538</a>, <a href="https://www.uniprot.org/uniprot/P51681" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">P51681</a>, <a href="https://www.uniprot.org/uniprot/Q9UPA4" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">Q9UPA4</a></dd>
|
||
<dt>UniProtKB/TrEMBL</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/A0A089G3J8" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G3J8</a>, <a href="https://www.uniprot.org/uniprot/A0A089G3L9" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G3L9</a>, <a href="https://www.uniprot.org/uniprot/A0A089G3M1" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G3M1</a>, <a href="https://www.uniprot.org/uniprot/A0A089G3N1" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G3N1</a>, <a href="https://www.uniprot.org/uniprot/A0A089G3P4" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G3P4</a>, <a href="https://www.uniprot.org/uniprot/A0A089G5N2" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G5N2</a>, <a href="https://www.uniprot.org/uniprot/A0A089G6S3" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G6S3</a>, <a href="https://www.uniprot.org/uniprot/A0A089G7J6" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089G7J6</a>, <a href="https://www.uniprot.org/uniprot/A0A089H983" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089H983</a>, <a href="https://www.uniprot.org/uniprot/A0A089H987" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">A0A089H987</a>, <a href="https://www.uniprot.org/uniprot/B0EX00" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">B0EX00</a>, <a href="https://www.uniprot.org/uniprot/B0EX01" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">B0EX01</a>, <a href="https://www.uniprot.org/uniprot/B2KIU0" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">B2KIU0</a>, <a href="https://www.uniprot.org/uniprot/B2KIU1" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">B2KIU1</a>, <a href="https://www.uniprot.org/uniprot/B2KKJ9" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">B2KKJ9</a>, <a href="https://www.uniprot.org/uniprot/H9MHP3" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">H9MHP3</a>, <a href="https://www.uniprot.org/uniprot/H9MHP6" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">H9MHP6</a>, <a href="https://www.uniprot.org/uniprot/H9MHP8" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">H9MHP8</a>, <a href="https://www.uniprot.org/uniprot/H9MHP9" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">H9MHP9</a>, <a href="https://www.uniprot.org/uniprot/L7S2Y4" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">L7S2Y4</a>, <a href="https://www.uniprot.org/uniprot/Q38L21" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">Q38L21</a>, <a href="https://www.uniprot.org/uniprot/Q3L3Q6" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">Q3L3Q6</a>, <a href="https://www.uniprot.org/uniprot/Q5EKM9" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">Q5EKM9</a>, <a href="https://www.uniprot.org/uniprot/Q5QIN9" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">Q5QIN9</a>, <a href="https://www.uniprot.org/uniprot/Q5QIP1" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">Q5QIP1</a></dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSP00000292303.4" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">ENSP00000292303.4</a>, <a href="http://www.ensembl.org/id/ENST00000292303.5" ref="itool=Gene_FullReport&PrId=5380&uid=1234&nlmid=&db=gene">ENST00000292303.5</a></dd>
|
||
<dt class="clear"> Conserved Domains (1) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001381712.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=341338">cd15184</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">31</span> → <span class="cddto">308</span></dt>
|
||
<dd class="clearfix"> 7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
<h3 class="genomerefseqs gene_std_toggler" id="annotatedrefseq-title">
|
||
<a class="jig-ncbitoggler-open">RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08</a>
|
||
</h3>
|
||
<div class="genomerefseqs_slave">
|
||
<p class="desc"> The following sections contain reference sequences that belong to a
|
||
specific genome build. <a href="#" id="expl-genomes">Explain</a></p>
|
||
<p id="expl-genomes-desc" style="display:none">This section includes genomic Reference
|
||
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
|
||
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
|
||
assemblies. Model RNAs and proteins are also reported here.</p>
|
||
<h3 id="refseq-sequencedescription-p113272416">Reference GRCh38.p14 Primary Assembly</h3>
|
||
<h4 id="genomic-p113272416">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NC_000003.12 Reference GRCh38.p14 Primary Assembly</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>46370142..46376206</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NC_000003.12?from=46370142&to=46376206&report=genbank" ref="ordinalpos=1&ncbi_uid=1234&link_uid=NC_000003.12?from=46370142&to=46376206&report=genbank">GenBank</a>, <a href="/nuccore/NC_000003.12?from=46370142&to=46376206&report=fasta" ref="ordinalpos=1&ncbi_uid=1234&link_uid=NC_000003.12?from=46370142&to=46376206&report=fasta">FASTA</a>, <a href="/nuccore/NC_000003.12?from=46369231&to=46377115&report=graph&content=5" ref="ordinalpos=1&ncbi_uid=1234&link_uid=NC_000003.12?from=46369231&to=46377115&report=graph&content=5">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
<h3 id="refseq-sequencedescription-p128931936">Alternate T2T-CHM13v2.0</h3>
|
||
<h4 id="genomic-p128931936">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NC_060927.1 Alternate T2T-CHM13v2.0</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>46385976..46392040</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NC_060927.1?from=46385976&to=46392040&report=genbank" ref="ordinalpos=1&ncbi_uid=1234&link_uid=NC_060927.1?from=46385976&to=46392040&report=genbank">GenBank</a>, <a href="/nuccore/NC_060927.1?from=46385976&to=46392040&report=fasta" ref="ordinalpos=1&ncbi_uid=1234&link_uid=NC_060927.1?from=46385976&to=46392040&report=fasta">FASTA</a>, <a href="/nuccore/NC_060927.1?from=46385065&to=46392949&report=graph&content=5" ref="ordinalpos=1&ncbi_uid=1234&link_uid=NC_060927.1?from=46385065&to=46392949&report=graph&content=5">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-related-sequences">
|
||
<section class="rprt-section-header" id="related-sequences">
|
||
<h2 id="header-related-sequences">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-related-sequences .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Related sequences</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Related_Sequences" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<table id="proteinTblId" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/1234/data/related-sequences/',webserviceParams: 'p$l=Ajax', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th colspan="2" id="rs-nucleo">Nucleotide</th>
|
||
<th rowspan="2" id="rs-protein">Protein</th>
|
||
</tr>
|
||
<tr>
|
||
<th id="rs-heading">Heading</th>
|
||
<th id="rs-heading-acc">Accession and Version</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody></tbody>
|
||
</table>
|
||
<table id="proteinTblId" class="jig-ncbigrid" data-jigconfig="isPageable:true, pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th class="proteinTblTh" rowspan="2" id="rs-prot-acc">Protein Accession</th>
|
||
<th class="proteinTblTh" colspan="2" id="rs-link">Links</th>
|
||
</tr>
|
||
<tr>
|
||
<th id="rs-genepept">GenPept Link</th>
|
||
<th id="rs-uniprot">UniProtKB Link</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="rs-prot-acc">P51681.1</td>
|
||
<td headers="rs-link rs-genepept">
|
||
<a href="/protein/1705896" ref="ordinalpos=1&ncbi_uid=1234&link_uid=1705896">GenPept</a>
|
||
</td>
|
||
<td>
|
||
<a href="https://www.uniprot.org/uniprot/P51681">UniProtKB/Swiss-Prot:P51681</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-additional-links">
|
||
|
||
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
|
||
|
||
<div class="rprt-section-body" style="">
|
||
<div id="lsdb"><h3 class="withnote" id="locusspecificdatabases"><a class="jig-ncbitoggler-open">Locus-specific Databases</a></h3><div><ul class="locusdb"><li><a href="http://databases.lovd.nl/shared/genes/CCR5" ref="from_uid=1234" class="lsdblink">CCR5 database</a></li></ul></div></div>
|
||
|
||
<h3 class="withnote" id="genelinkout">
|
||
<a class="jig-ncbitoggler">Gene LinkOut</a>
|
||
</h3><div>
|
||
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
|
||
<div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Chemical Information</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Interologous Interaction Database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://ophid.utoronto.ca/redirect/ncbi/human?proteins=1234" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=7911">
|
||
<span>Interologous Interaction Database</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>MilliporeSigma</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.sigmaaldrich.com/catalog/genes/CCR5?lang=en&region=US" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=9978">
|
||
<span>Ccr5 products</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Molecular Biology Databases</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Bgee database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.bgee.org/gene/ENSG00000160791" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=10418">
|
||
<span>CCR5 gene expression</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>BioGPS</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://biogps.org/gene/1234/" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=5059">
|
||
<span>BioGPS</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>BioGRID Open Repository of CRISPR Screens (ORCS)</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://orcs.thebiogrid.org/Gene/1234" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=10164">
|
||
<span>BioGRID CRISPR Screen Phenotypes (17 hits/1362 screens)</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Domain Mapping of Disease Mutations</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://bioinf.umbc.edu/DMDM/gene_prot_page.php?id=1234" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=7642">
|
||
<span>CCR5</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>GlyGen glycoinformatics resource</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://glygen.org/protein/P51681" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=10227">
|
||
<span>GlyGen glycoinformatics resource</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Guide to Pharmacology</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=62" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=8191">
|
||
<span>CCR5 gene</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span><span class="regis-rsc"></span>Human Gene Mutation Database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.hgmd.cf.ac.uk/ac/gene.php?gene=CCR5" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=3100">
|
||
<span>Human Gene Mutation Database</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Human eFP Browser</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Nervous&modeInput=Absolute&primaryGene=1234" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=8875">
|
||
<span>Human eFP Browser</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Reproductive&modeInput=Absolute&primaryGene=1234" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=8875">
|
||
<span>Human eFP Browser</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Skeletal_Immune_Digestive&modeInput=Absolute&primaryGene=1234" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=8875">
|
||
<span>Human eFP Browser</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li>Ingenuity Pathways Analysis</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://partnersolution.ingenuity.com/?cid=97ae3f91eab87a&p1=Entrez&p2=GV&s=&ipaUri=%2Fpa%2Fapi%2Fv2%2Fgeneview%3Fapplicationname%3DEntrez%26geneId%3D1234%26geneidtype%3Dentrezgene" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=5628">
|
||
<span>Ingenuity Pathways Analysis</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>InnateDB</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.innatedb.com/getGeneCard.do?id=30229" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=7894">
|
||
<span>InnateDB</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>InterMine</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.humanmine.org/humanmine/search?keyword=ENSG00000160791" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=9169">
|
||
<span>InterMine</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Kyoto Encyclopedia of Genes and Genomes</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.genome.jp/dbget-bin/www_bget?hsa:1234" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=5174">
|
||
<span>Kyoto Encyclopedia of Genes and Genomes</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>OMA Browser: Orthologous MAtrix</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN69650/" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=9822">
|
||
<span>OMA Browser: Orthologous MAtrix</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN69649/" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=9822">
|
||
<span>OMA Browser: Orthologous MAtrix</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>OrthoDB catalog of orthologs</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.orthodb.org/?ncbi=1234" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=8178">
|
||
<span>Orthologs</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Pharmacogenomics Knowledge Base</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.pharmgkb.org/gene/PA26170" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=4067">
|
||
<span>Annotated Pharmacogenomic Information for CCR5 [PharmGKB]</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>PhosphoSitePlus</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.phosphosite.org/entrezGeneIdAction.action?id=1234" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=7987">
|
||
<span>PhosphoSitePlus® - comprehensive post-translational modification resource</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>The Gene Wiki</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://en.wikipedia.org/wiki/CCR5" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=6933">
|
||
<span>The Gene Wiki</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>The Weizmann Institute of Science GeneCards and MalaCards databases</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=CCR5" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=8598">
|
||
<span>GeneCard for CCR5</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Research Materials</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="order-rsc"></span>Addgene Non-profit plasmid repository</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://addgene.org//browse/gene/1234" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=5304">
|
||
<span>Get Plasmids - Addgene</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>Bio-Techne</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.bio-techne.com/t/ccr5/antibodies?utm_source=linkout&utm_medium=referral&utm_campaign=product&utm_term=antibodies" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=8242">
|
||
<span>CCR5 Antibodies</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.bio-techne.com/t/ccr5/lysates?utm_source=linkout&utm_medium=referral&utm_campaign=product&utm_term=lysates" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=8242">
|
||
<span>CCR5 Lysates</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.bio-techne.com/t/ccr5/proteins-enzymes?utm_source=linkout&utm_medium=referral&utm_campaign=product&utm_term=proteins" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=8242">
|
||
<span>CCR5 Proteins</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li>ExactAntigen/Labome</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.labome.com/gene/human/CCR5-antibody.html" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=5753">
|
||
<span>reagents</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.labome.com/review/gene/human/CCR5-antibody.html" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=5753">
|
||
<span>reagent review</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GenScript latest version of gene cDNA ORF Clone</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.genscript.com/gene/1234" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=8012">
|
||
<span>GenScript latest version of gene cDNA ORF Clone</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GeneCopoeia Inc.</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=26&field=5&key=1234" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order TALEN/CRISPR clones</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?tax_id=9606&field=5&prt=16&key=1234" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order miRNA target clones</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=1&field=5&key=1234" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order full-length ORF clone</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GeneTex Inc</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.genetex.com/Product/Search?geneid=1234&type=01&page=1" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=8117">
|
||
<span>Find Quality Antibodies</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>Kazusa DNA Research Institute</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.kazusa.or.jp/kop/dsearch/symsearch.cgi?keyword=CCR5;" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=3267">
|
||
<span>Kazusa DNA Research Institute</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>OriGene</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.origene.com/search?q=CCR5" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=7994">
|
||
<span>Order CCR5 cDNA clone/Protein/Antibody/RNAi</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Tools</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>GeneMANIA</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://genemania.org/link?o=9606&g=1234" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=7529">
|
||
<span>GeneMANIA</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open">
|
||
<span>Miscellaneous</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Reactome</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-1643685" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=4914">
|
||
<span>Reactome Event:Disease</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-162582" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=4914">
|
||
<span>Reactome Event:Signal Transduction</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-168256" ref="itool=Gene_FullReport&uid=1234&nlmid=&db=gene&log$=linkoutlink&PrId=4914">
|
||
<span>Reactome Event:Immune System</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="urls-in-genombrowser" style="display:none">
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div><input type="hidden" class="section_status_input" name="status_checked" id="status_checked" value="" /><input type="hidden" class="section_status_input" name="status_open" id="status_open" value="summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links" /><input type="hidden" class="section_status_input" name="status_exist" id="status_exist" value="summary,context,region,expression,bibliography,phenotypes,variation,hiv,,interactions,geneInfo,proteinInfo,refSeq,related,links" /><input type="hidden" class="section_status_input" name="status_closed" id="status_closed" value="" /><meta name="status_checked" content="" class="meta_section_status" /><meta name="status_open" content="summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links" class="meta_section_status" /><meta name="status_exist" content="summary,context,region,expression,bibliography,phenotypes,variation,hiv,,interactions,geneInfo,proteinInfo,refSeq,related,links" class="meta_section_status" /><meta name="status_closed" content="" class="meta_section_status" /><script type="text/javascript">
|
||
|
||
var section_status_meta = {
|
||
'status_checked': '',
|
||
'status_open': 'summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links',
|
||
'status_exist': 'summary,context,region,expression,bibliography,phenotypes,variation,hiv,,interactions,geneInfo,proteinInfo,refSeq,related,links',
|
||
'status_closed': ''
|
||
};
|
||
|
||
|
||
/*
|
||
for (var o in section_status_meta) {
|
||
var meta=document.createElement('meta');
|
||
meta.name = o;
|
||
meta.content = section_status_meta[o];
|
||
var attr = document.createAttribute('data-ignore-limit');
|
||
attr.value = 'true';
|
||
meta.setAttributeNode(attr);
|
||
document.getElementsByTagName('head')[0].appendChild(meta);
|
||
}
|
||
*/
|
||
|
||
|
||
var __ncbi_sg_pingCallbacks_render_gene = function (data, evtObj, type) {
|
||
// data looks like {jsevent: "click", "link_id": "foo", ...}
|
||
// evtObj is the JS event object
|
||
// type is either "stat" (for applog) or "ga"
|
||
var extraData = {};
|
||
if (type == "stat") {
|
||
for (var o in section_status_meta) {
|
||
extraData[o] = section_status_meta[o];
|
||
}
|
||
|
||
return extraData;
|
||
|
||
}
|
||
}
|
||
|
||
|
||
</script></div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last" id="sidebar_tabular">
|
||
<!-- sidebar close/hide button-->
|
||
<div class="ui-helper-clearfix">
|
||
<a href="#" id="sidecontent_2_pullout" style="float:right;" class="sidecontentpullout_local collapse_button"><span>Hide sidebar >></span></a>
|
||
</div>
|
||
<!-- end sidebar close/hide button-->
|
||
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div id="gene-sidebar">
|
||
<div>
|
||
<div class="portlet brieflink dis-table-of-contents">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Table of contents</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li class="">
|
||
<a href="#summary">Summary</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#genomic-context">Genomic context</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#gene-expression">Expression</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#bibliography">Bibliography</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#phenotypes">Phenotypes</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#variation">Variation</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#HIV-1-interactions">HIV-1 interactions</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#pathways">Pathways from PubChem</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#interactions">Interactions</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#general-gene-info">General gene information</a>
|
||
<div class="subsection-links"><a href="#gene-markers">Markers</a>, <a href="#CloneNames">Clone Names</a>, <a href="#homology">Homology</a>, <a href="#gene-ontology">Gene Ontology</a></div>
|
||
</li>
|
||
<li class="">
|
||
<a href="#general-protein-info">General protein information</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#reference-sequences">NCBI Reference Sequences (RefSeq)</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#related-sequences">Related sequences</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#additional-links">Additional links</a>
|
||
<div class="subsection-links">
|
||
<a href="#lsdb">Locus-specific Databases</a>
|
||
</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Genome Browsers</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GenomeBrowsers" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="#">Loading...</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet dis-related-info brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clone/order/gene/1234" ref="log$=recordlinks">Order cDNA clone</a>
|
||
<div class="brieflinkpop offscreen_noflow">Order cDNA clone</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/structure?LinkName=gene_structure&from_uid=1234" ref="log$=recordlinks">3D structures</a>
|
||
<div class="brieflinkpop offscreen_noflow">3D structure of a gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_alltarget_list&from_uid=1234" ref="log$=recordlinks">BioAssay by Target (List)</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays related to the gene by protein target or RNAi target</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="//pubchem.ncbi.nlm.nih.gov/assay/bioactivity.html?geneid=1234" ref="log$=recordlinks">BioAssay by Target (Summary)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Summarized PubChem Data on the gene, showing the active data by default</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_target&from_uid=1234" ref="log$=recordlinks">BioAssay, by Gene target</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem BioAssays done on the Gene target</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai_active&from_uid=1234" ref="log$=recordlinks">BioAssays, RNAi Target, Active</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent, which is identified as a hit in a RNAi screening and flagged as "active" in the corresponding BioAssay record</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai&from_uid=1234" ref="log$=recordlinks">BioAssays, RNAi Target, Tested</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&from_uid=1234" ref="log$=recordlinks">BioProjects</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/biosystems?LinkName=gene_biosystems&from_uid=1234" ref="log$=recordlinks">BioSystems</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioSystems</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/books?LinkName=gene_books&from_uid=1234" ref="log$=recordlinks">Books</a>
|
||
<div class="brieflinkpop offscreen_noflow">Books</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/CCDS/CcdsBrowse.cgi?REQUEST=GENEID&DATA=1234" ref="log$=recordlinks">CCDS</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to CCDS</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar&from_uid=1234" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/cdd?LinkName=gene_cdd&from_uid=1234" ref="log$=recordlinks">Conserved Domains</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related CDD</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/dbvar?LinkName=gene_dbvar&from_uid=1234" ref="log$=recordlinks">dbVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link from Gene to dbVar</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&from_uid=1234" ref="log$=recordlinks">Full text in PMC</a>
|
||
<div class="brieflinkpop offscreen_noflow">PMC links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&from_uid=1234" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
|
||
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/sparcle?LinkName=gene_sparcle&from_uid=1234" ref="log$=recordlinks">Functional Class</a>
|
||
<div class="brieflinkpop offscreen_noflow">Functional class of the sequence domain architecture</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gap?LinkName=gene_gap&from_uid=1234" ref="log$=recordlinks">GAP</a>
|
||
<div class="brieflinkpop offscreen_noflow">GAP Links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&from_uid=1234" ref="log$=recordlinks">Gene neighbors</a>
|
||
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/genome?LinkName=gene_genome&from_uid=1234" ref="log$=recordlinks">Genome</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Genome</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/geoprofiles?LinkName=gene_geoprofiles&from_uid=1234" ref="log$=recordlinks">GEO Profiles</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related GEO</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests/?term=1234[geneid]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Tests for this gene in the NIH Genetic Testing Registry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/homologene?LinkName=gene_homologene&from_uid=1234" ref="log$=recordlinks">HomoloGene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related HomoloGene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/medgen?LinkName=gene_medgen_diseases&from_uid=1234" ref="log$=recordlinks">MedGen</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in MedGen</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&from_uid=1234" ref="log$=recordlinks">Nucleotide</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=gene_omim&from_uid=1234" ref="log$=recordlinks">OMIM</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related OMIM entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/probe?LinkName=gene_probe&from_uid=1234" ref="log$=recordlinks">Probe</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Probe entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein&from_uid=1234" ref="log$=recordlinks">Protein</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related protein entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pccompound?LinkName=gene_pccompound&from_uid=1234" ref="log$=recordlinks">PubChem Compound</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem Compounds</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcsubstance?LinkName=gene_pcsubstance&from_uid=1234" ref="log$=recordlinks">PubChem Substance</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem Substances</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&from_uid=1234" ref="log$=recordlinks">PubMed</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_rif&from_uid=1234" ref="log$=recordlinks">PubMed (GeneRIF)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related PubMed article from GeneRIFs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_citedinomim&from_uid=1234" ref="log$=recordlinks">PubMed (OMIM)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Gene links to PubMed derived from omim_pubmed_cited links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&from_uid=1234" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein_refseq&from_uid=1234" ref="log$=recordlinks">RefSeq Proteins</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to Protein RefSeqs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore_refseqrna&from_uid=1234" ref="log$=recordlinks">RefSeq RNAs</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeq RNAs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/nuccore/255652911?report=graph" ref="log$=recordlinks">RefSeqGene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeqGenes</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar_specific&from_uid=1234" ref="log$=recordlinks">Related gene-specific medical variations</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/snp?LinkName=gene_snp&from_uid=1234" ref="log$=recordlinks">SNP</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related SNP records</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&from_uid=1234" ref="log$=recordlinks">Taxonomy</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/variation/view/?q=1234[geneid]" ref="log$=recordlinks">Variation Viewer</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Variants</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet dis-links-to-other-res brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Links to other resources</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_LinksTwo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1606">HGNC</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://www.ensembl.org/id/ENSG00000160791">Ensembl</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.alliancegenome.org/gene/HGNC:1606">AllianceGenome</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&org=9606&l=1234">AceView</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://databases.lovd.nl/shared/genes/CCR5">CCR5 database</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_000579">UCSC</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://genecollections.nci.nih.gov/MGC/?ORG=Hs&LIST=BC038398">MGC</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=CCR5&geneID=1234&typeOption=gene&which=2&pubOrderType=pubD&typeSubmit=GO&check=y">HuGE Navigator</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://www.genome.jp/dbget-bin/www_bget?hsa:1234">KEGG</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-general-info">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>General information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GeneralInfo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pmc/?term=PMC4383897+OR+PMC3013746+OR+PMC1761442+OR+PMC539985">About Gene</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3840">FAQ</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3841/">Help</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3842/">My NCBI help</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK21085/">NCBI Handbook</a>
|
||
</li>
|
||
<li>
|
||
<a href="/gene/statistics/">Statistics</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-related-sites">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related sites</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_RelatedSites" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/genome">Genome</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/">Genome Data Viewer</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/geo">GEO</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/omim">OMIM</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-feedback">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Feedback</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Feedback" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://support.ncbi.nlm.nih.gov/ics/support/ticketnewwizard.asp?style=classic&deptID=28049">Contact Help Desk</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/RefSeq/update.cgi?geneid=1234&symbol=CCR5">Submit Correction</a>
|
||
</li>
|
||
<li>
|
||
<a href="/gene/submit-generif?geneId=1234&sym=CCR5&name=C-C motif chemokine receptor 5&org=Homo sapiens">Submit GeneRIF</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-subscription">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Subscription</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Subscription" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/mailman/listinfo/refseq-announce">RefSeq</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<!-- <component id="Gene_RVFullReport.Gene_RightColMenuLinks"/>-->
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Recent activity</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<div id="HTDisplay" class="">
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Cmd" sid="1" type="hidden" />
|
||
<div class="action">
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory">
|
||
Clear
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn Off
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" sid="2" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOff" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn On
|
||
</a>
|
||
</div>
|
||
<ul id="activity">
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67c9d82df4a390645e066a09">CCR5 C-C motif chemokine receptor 5 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">CCR5 C-C motif chemokine receptor 5 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:1234</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67c9d82b84f3725e59067b68">C-C chemokine receptor type 5 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">C-C chemokine receptor type 5 [Homo sapiens]<div class="brieflinkpopdesc">gi|4502639|ref|NP_000570.1|</div></div>
|
||
<div class="tertiary">Protein</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67c9d828a68b6b5afc402205">CCR4 C-C motif chemokine receptor 4 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">CCR4 C-C motif chemokine receptor 4 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:1233</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67c9d826b15b832ebcdacd72">C-C chemokine receptor type 4 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">C-C chemokine receptor type 4 [Homo sapiens]<div class="brieflinkpopdesc">gi|5031627|ref|NP_005499.1|</div></div>
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<div class="tertiary">Protein</div>
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|
||
<div class="ralinkpop offscreen_noflow">CCR3 C-C motif chemokine receptor 3 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:1232</div></div>
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<div class="tertiary">Gene</div>
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