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3464 lines
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263 KiB
XML
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<h1 class="res_name"><a href="/gene/">Gene</a></h1>
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<h2 class="res_tagline">Genes and mapped phenotypes</h2>
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<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pubmed">PubMed</option><option value="clinvar">ClinVar</option><option value="medgen">MedGen</option><option value="books" class="last">Books</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly" data-ac_dict="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene" selected="selected" data-ac_dict="gene">Gene</option><option value="genome" data-ac_dict="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore" data-ac_dict="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein" data-ac_dict="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Gene. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'gene',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a href="/gene/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3841/">Help</a></li></ul></div>
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<input name="EntrezSystem2.PEntrez.Gene.Gene_PageController.PreviousPageName" sid="1" type="hidden" value="results" />
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<div id="faceted_search" class="facet_hide">
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<h2 class="offscreen_noflow">Result Filters</h2>
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<div class="facet_cont" data-db="gene" data-default_grps="fg_gene-sources,fg_categories,fg_sequence-content,fg_status" data-sd="db:'gene',op:'select',term:'',qk:'7264',linkname:'',idsfromresult:'11168',extra:''"><ul class="facet" data-filter_id="gene-sources" id="_gene-sources"><li class="filter_grp "><div class="clearfix"><h3>Gene sources</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="genomic">Genomic</a></li></ul></li></ul><ul class="facet" data-filter_id="categories" id="_categories"><li class="filter_grp "><div class="clearfix"><h3>Categories</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="alt-splicing">Alternatively spliced</a></li><li class="fil_val"><a href="#" data-value_id="annotated-genes">Annotated genes</a></li><li class="fil_val"><a href="#" data-value_id="gene-type-protein-coding">Protein-coding</a></li></ul></li></ul><ul class="facet" data-filter_id="sequence-content" id="_sequence-content"><li class="filter_grp "><div class="clearfix"><h3>Sequence content</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="seq-ccds">CCDS</a></li><li class="fil_val"><a href="#" data-value_id="seq-ensembl">Ensembl</a></li><li class="fil_val"><a href="#" data-value_id="refseq">RefSeq</a></li></ul></li></ul><ul class="facet" data-filter_id="status" id="_status"><li class="filter_grp "><div class="clearfix"><h3>Status</h3><a href="#" data-value_id="" class="clear clear_show">Clear</a></div><ul><li class="fil_val selected"><a href="#" data-value_id="current-only">Current</a><span class="fcount">(1)</span></li></ul></li></ul><div id="chr-location-facet-wrapper" data-bid="MCID_67ca00cb69195c35ad7604d0" data-hid="MCID_67c90f2d64f30b25346ccae2" data-qky="7264" class="disabled" style="display:none"><ul class="facet" data-filter_id="chromosomal-region" id="_chromosomal-region" data-of="yes"><li class="filter_grp of_grp"><div class="clearfix"><h3>Chromosome locations</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><a id="facet_ofchromosomal-region" href="#facet_of_divchromosomal-region" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'" data-value_id="fetch_more">more...</a><div id="facet_of_divchromosomal-region" style="display:none;" class="of_popup"><h4>Chromosome locations</h4><label for="organism-filter" style="width:100%;margin-bottom:.2em;" class="">Select an organism by typing or scrolling</label><input type="text" placeholder="Enter text to narrow down the list" id="organism-filter" style="width:98%;" autocomplete="off" /><br /><div id="chr-region-tax-list"><select id="of_chromosomal-region" size="9" class="chr-region-tax-list" style="width:100%;"></select></div><div id="chr-location-info-ctrl" data-disabled="disabled"><div class="chr-field"><label for="chr-name">Chromosome</label><br /><select id="chr-name" class="chr-field" disabled="disabled"></select></div><div class="chr-field"><label for="chr-from">From</label><br /><input type="text" name="chr-from" id="chr-from" disabled="disabled" class="chr-field" /></div><div class="chr-field"><label for="chr-to">To</label><br /><input type="text" name="chr-to" id="chr-to" disabled="disabled" class="chr-field" /></div></div><div class="actions clearfix"><button class="jig-ncbibutton of_add apply-chr" data-jigconfig="'color': 'ui-ncbibutton-blue'">Apply</button></div></div></ul></li></ul></div><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
|
||
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_gene-sources" /><label for="fg_gene-sources">Gene sources</label></li><li><input type="checkbox" id="fg_categories" /><label for="fg_categories">Categories</label></li><li><input type="checkbox" id="fg_sequence-content" /><label for="fg_sequence-content">Sequence content</label></li><li><input type="checkbox" id="fg_status" /><label for="fg_status">Status</label></li><li><input type="checkbox" id="fg_chromosomal-region" /><label for="fg_chromosomal-region">Chromosome locations</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=current-only" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.Gene.Gene_Facets.BMFacets" sid="1" type="hidden" value="" /></div>
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<span style="display: block; text-align: center;">S</span>
|
||
<span style="display: block; text-align: center;">I</span>
|
||
<span style="display: block; text-align: center;">D</span>
|
||
<span style="display: block; text-align: center;">E</span>
|
||
<span style="display: block; text-align: center;">B</span>
|
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<span style="display: block; text-align: center;">A</span>
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<span style="display: block; text-align: center;">R</span>
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<div class="results_settings one_setting"><ul class="inline_list left display_settings"><li><a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Display" sid="0" href="#" class="jig-ncbipopper" data-jigconfig="triggerPosition : 'bottom center',destPosition : 'top center',destSelector : '#display_settings_menu_report', hasArrow : false,openEvent : 'click',closeEvent : 'click',isTriggerElementCloseClick: false,addCloseButton : false, groupName: 'entrez_pg'" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Display">Full Report<span href="#" class="tgt_dark"></span></a></li></ul><div id="display_settings_menu_report" class="disp_settings tabPopper"><fieldset class="format"><legend>Format</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="1" value="full_report" format="" id="full_report" checked="true" /><label for="full_report">Full Report</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="2" value="full_report" format="text" id="full_reporttext" /><label for="full_reporttext">Full Report (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="3" value="expression" format="" id="expression" /><label for="expression">Expression</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="4" value="gene_table" format="" id="gene_table" /><label for="gene_table">Gene Table</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="5" value="gene_table" format="text" id="gene_tabletext" /><label for="gene_tabletext">Gene Table (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="6" value="generif" format="" id="generif" /><label for="generif">GeneRIF</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="7" value="docsum" format="" id="docsum" /><label for="docsum">Summary</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="8" value="docsum" format="text" id="docsumtext" /><label for="docsumtext">Summary (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="9" value="tabular" format="" id="tabular" /><label for="tabular">Tabular</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="10" value="tabular" format="text" id="tabulartext" /><label for="tabulartext">Tabular (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="11" value="asn1" format="text" id="asn1text" /><label for="asn1text">ASN.1</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="12" value="xml" format="text" id="xmltext" /><label for="xmltext">XML</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.sPresentation" sid="13" value="uilist" format="text" id="uilisttext" /><label for="uilisttext">UI List</label></li></ul></fieldset></div><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SetDisplay" sid="1" class="button_apply ncbipopper-close-button" style="display:none">Apply</button><h4 class="content_header send_to align_right jig-ncbipopper" id="sendto" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#send_to_menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, addCloseButton:true, groupName: 'entrez_pg', adjustFit:'none'"><a href="#" sourceContent="send_to_menu" class="tgt_dark">Send to:</a><script type="text/javascript">
|
||
jQuery(document).ready( function () {
|
||
jQuery("#send_to_menu input[type='radio']").click( function () {
|
||
var selectedValue = jQuery(this).val().toLowerCase();
|
||
var selectedDiv = jQuery("#send_to_menu div." + selectedValue);
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||
if(selectedDiv.is(":hidden")){
|
||
jQuery("#send_to_menu div.submenu:visible").slideUp();
|
||
selectedDiv.slideDown();
|
||
}
|
||
});
|
||
|
||
});
|
||
|
||
jQuery("#sendto").bind("ncbipopperclose", function(){
|
||
jQuery("#send_to_menu div.submenu:visible").css("display","none");
|
||
jQuery("#send_to_menu input[type='radio']:checked").attr("checked",false);
|
||
});
|
||
|
||
</script></h4><div id="send_to_menu" class="tabPopper send_to"><fieldset><legend>Choose Destination</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="1" value="File" id="dest_File" /><label for="dest_File">File</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="2" value="AddToClipboard" id="dest_AddToClipboard" /><label for="dest_AddToClipboard">Clipboard</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendTo" sid="3" value="AddToCollections" id="dest_AddToCollections" /><label for="dest_AddToCollections">Collections</label></li></ul></fieldset><div class="submenu file" id="submenu_File" style="display: none;"><p id="submenu_File_hint" class="hidden"></p><ul><li><label for="file_format">Format</label><select id="file_format" name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FFormat" sid="1"><option value="full_report" format="text" selected="selected">Full Report (text)</option><option value="gene_table" format="text">Gene Table (text)</option><option value="docsum" format="text">Summary (text)</option><option value="tabular" format="text">Tabular (text)</option><option value="asn1" format="text">ASN.1</option><option value="xml" format="text">XML</option><option value="uilist" format="text">UI List</option></select></li></ul><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="1" class="button_apply file ncbipopper-close-button" type="submit" cmd="File">Create File</button></div><div class="submenu addtoclipboard" id="submenu_AddToClipboard" style="display: none;"><p id="submenu_AddToClipboard_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="2" class="button_apply clipboard ncbipopper-close-button" type="submit" cmd="AddToClipboard">Add to Clipboard</button></div><div class="submenu addtocollections" id="submenu_AddToCollections" style="display: none;"><p id="submenu_AddToCollections_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.SendToSubmit" sid="3" class="button_apply collections ncbipopper-close-button" type="submit" cmd="AddToCollections">Add to Collections</button></div></div><div><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FileFormat" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastPresentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Presentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Sort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastSort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.FileSort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.Format" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.LastFormat" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevPresentation" sid="1" type="hidden" value="full_report" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_DisplayBar.PrevSort" sid="1" type="hidden" value="" /><input type="hidden" id="coll_startindex" name="CollectionStartIndex" value="1" /></div></div>
|
||
<div>
|
||
|
||
|
||
|
||
</div>
|
||
<div class="">
|
||
<div><span id="result_sel" class="nowrap"></span><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_ResultsController.ResultCount" sid="1" type="hidden" id="resultcount" value="1" /><input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_ResultsController.RunLastQuery" sid="1" type="hidden" /></div>
|
||
|
||
</div>
|
||
<div id="messagearea" class="empty">
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div class="rprt full-rprt">
|
||
<div>
|
||
<div class="rprt-header">
|
||
<input type="hidden" id="gene-tax-id" value="9606" />
|
||
<h1 class="title" id="gene-name"><span class="gn" style="padding-right:.5em;">PSIP1</span> PC4 and SRSF1 interacting protein 1 [ <em class="tax">Homo sapiens</em> (human)
|
||
]
|
||
</h1>
|
||
<span class="geneid">Gene ID: 11168, updated on
|
||
4-Mar-2025</span>
|
||
</div>
|
||
<div class="download-datasets">
|
||
<script type="text/javascript" src="https://cdnjs.cloudflare.com/ajax/libs/axios/0.23.0/axios.min.js"></script>
|
||
<h4 class="download-datasets-popper jig-ncbipopper" id="download-asm" style="align-self:start" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#download-datasets-popper-menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, groupName: 'entrez_pg', adjustFit:'none'" role="button" aria-expanded="false" aria-haspopup="true">
|
||
<svg alt="download" class="dlbtn-icon" x="0px" y="0px" width="15px" height="15px" viewBox="0 0 60 60" enable-background="new 0 0 60 60" xml:space="preserve">
|
||
<g>
|
||
<polygon points="48.75,36.25 48.75,48.75 11.25,48.75 11.25,36.25 5,36.25 5,55 55,55 55,36.25 "></polygon>
|
||
<polygon points="42.5,23.75 36.25,23.75 36.25,5 23.75,5 23.75,23.75 17.5,23.75 30,42.5 "></polygon>
|
||
</g>
|
||
</svg>
|
||
<a href="#">Download Datasets</a>
|
||
</h4>
|
||
<div id="download-datasets-popper-menu" style="display:none;">
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-gene-seq-fasta" value="FASTA_GENE" checked="checked" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-gene-seq-fasta">Gene Sequences (FASTA)</label>
|
||
</div>
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-transcript-seq-fasta" value="FASTA_RNA" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-transcript-seq-fasta">Transcript sequences (FASTA)</label>
|
||
</div>
|
||
<div class="input-group">
|
||
<input type="checkbox" id="datasets-ft-protein-seq-fasta" value="FASTA_PROTEIN" class="download-datasets-included-seq" />
|
||
<label for="datasets-ft-protein-seq-fasta">Protein sequences(FASTA)</label>
|
||
</div>
|
||
<p style="margin-left:5px;">In addition, your package will include a detailed data report in both TSV and JSONL formats.</p>
|
||
<div class="input-group">
|
||
<label for="datasets-download-file-name">File name</label>
|
||
<input type="text" id="datasets-download-file-name" placeholder="Name your file" style="padding:5px;" value="PSIP1_datasets.zip" />
|
||
</div>
|
||
<input type="hidden" id="download-datasets-base-url" value="https://api.ncbi.nlm.nih.gov/datasets/v2alpha/gene/download" />
|
||
<input type="hidden" id="gene-id-value" value="11168" />
|
||
<button id="datasets-download-submit" data-ga-action="click_begin_download" data-ga-label="download" class="jig-ncbibutton ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-gray" role="button">
|
||
<span class="ui-button-text">Download</span>
|
||
</button>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-body">
|
||
|
||
|
||
<div class="rprt-section gene-summary">
|
||
<section class="rprt-section-header" id="summary">
|
||
<h2 id="header-summary">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-summary .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Summary</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Summary_2" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div id="summaryDiv" class="section">
|
||
<dl id="summaryDl">
|
||
<dt class="noline"> Official
|
||
Symbol</dt>
|
||
<dd class="noline">PSIP1<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
|
||
<dt> Official
|
||
Full Name</dt>
|
||
<dd>PC4 and SRSF1 interacting protein 1<span class="prov">provided by <a href="http://www.genenames.org/" target="_blank" title="HUGO Gene Nomenclature Committee">HGNC</a></span></dd>
|
||
<dt>Primary source</dt>
|
||
<dd>
|
||
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9527" data-gblink-text="Ensembl">HGNC:HGNC:9527</a>
|
||
</dd>
|
||
<dt>See related</dt>
|
||
<dd>
|
||
<a href="http://www.ensembl.org/id/ENSG00000164985" data-gblink-text="Ensembl" class="genome-browser-link" data-genome-browser-link-sort="5" data-gb-url="http://www.ensembl.org/loc/ENSG00000164985">Ensembl:ENSG00000164985</a>
|
||
<a href="https://www.ncbi.nlm.nih.gov/omim/603620" data-gblink-text="Ensembl" ref="ordinalpos=1&ncbi_uid=11168&link_uid=603620">MIM:603620;</a>
|
||
<a href="https://www.alliancegenome.org/gene/HGNC:9527" data-gblink-text="Ensembl" ref="ordinalpos=1&ncbi_uid=11168&link_uid=HGNC:9527">AllianceGenome:HGNC:9527</a>
|
||
</dd>
|
||
<dt>Gene type</dt>
|
||
<dd>protein coding</dd>
|
||
<dt>RefSeq status</dt>
|
||
<dd>VALIDATED</dd>
|
||
<dt>Organism</dt>
|
||
<dd class="tax">
|
||
<a href="/Taxonomy/Browser/wwwtax.cgi?id=9606" ref="ordinalpos=1&ncbi_uid=11168&link_uid=9606">Homo sapiens</a>
|
||
</dd>
|
||
<dt>Lineage</dt>
|
||
<dd class="tax">Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo</dd>
|
||
<dt>Also known as</dt>
|
||
<dd>p52; p75; PAIP; DFS70; LEDGF; PSIP2</dd>
|
||
<dt>Summary</dt>
|
||
<dd>Enables DNA-binding transcription factor binding activity; chromatin binding activity; and transcription coactivator activity. Involved in mRNA 5'-splice site recognition and positive regulation of transcription by RNA polymerase II. Located in heterochromatin; nuclear periphery; and nucleoplasm. [provided by Alliance of Genome Resources, Feb 2025]</dd>
|
||
<dt>Expression</dt>
|
||
<dd>Ubiquitous expression in brain (RPKM 41.2), ovary (RPKM 33.4) and 24 other tissues <a href="#gene-expression">See more</a></dd>
|
||
<dt>Orthologs</dt>
|
||
<dd class="ortholog-links">
|
||
<a href="https://www.ncbi.nlm.nih.gov/gene/101739">mouse</a>
|
||
<a href="/gene/11168/ortholog/">all</a>
|
||
</dd>
|
||
<dt style="padding-top:.5em;">
|
||
<span class="new-icon">NEW</span>
|
||
</dt>
|
||
<dd style="padding-top:.5em;">
|
||
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/11168/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="gene_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Gene table</a></strong>
|
||
<br />
|
||
<strong>Try the new <a href="https://www.ncbi.nlm.nih.gov/datasets/gene/id/11168/products/" data-ga-category="summary" data-ga-action="click_datasets_link" data-ga-label="transcript_table" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report.">Transcript table</a></strong>
|
||
</dd>
|
||
</dl>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-genomic-context">
|
||
<section class="rprt-section-header" id="genomic-context">
|
||
<h2 id="header-genomic-context">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-context .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Genomic context</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Genomic_Context" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div class="gc_cont">
|
||
<div class="gt_cont_contents">
|
||
<div style="float:right"><span>See PSIP1 in </span><a href="/genome/gdv/?context=gene&acc=11168" class="link-to-gdv genome-browser-link" data-genome-browser-link-sort="1" data-acc="GCF_000001405.40">Genome Data Viewer</a> </div>
|
||
<dl class="dl-chr-info" style="float:left;margin-top:0;">
|
||
<dt>Location: </dt>
|
||
<dd>
|
||
<span style="display:inline-block;">9p22.3</span>
|
||
</dd>
|
||
</dl>
|
||
</div>
|
||
<dl class="dl-chr-info exon-count">
|
||
<dt>Exon count: </dt>
|
||
<dd>18</dd>
|
||
</dl>
|
||
<div class="ui-ncbigrid-outer-div" id="genomic-context-tbl-location">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="">
|
||
<thead>
|
||
<tr>
|
||
<th style="max-width:15%">Annotation release</th>
|
||
<th style="max-width:10%">Status</th>
|
||
<th>Assembly</th>
|
||
<th>
|
||
<span title="Chromosome">Chr</span>
|
||
</th>
|
||
<th>Location</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td>RS_2024_08</td>
|
||
<td>current</td>
|
||
<td>GRCh38.p14 (<a href="/assembly/GCF_000001405.40/" ref="ncbi_uid=11168&link_uid=GCF_000001405.40">GCF_000001405.40</a>)</td>
|
||
<td>9</td>
|
||
<td>NC_000009.12 (15464066..15510970, complement) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>RS_2024_08</td>
|
||
<td>current</td>
|
||
<td>T2T-CHM13v2.0 (<a href="/assembly/GCF_009914755.1/" ref="ncbi_uid=11168&link_uid=GCF_009914755.1">GCF_009914755.1</a>)</td>
|
||
<td>9</td>
|
||
<td>NC_060933.1 (15475998..15522882, complement) </td>
|
||
</tr>
|
||
<tr>
|
||
<td>RS_2024_09</td>
|
||
<td>previous assembly</td>
|
||
<td>GRCh37.p13 (<a href="/assembly/GCF_000001405.25/" ref="ncbi_uid=11168&link_uid=GCF_000001405.25">GCF_000001405.25</a>)</td>
|
||
<td>9</td>
|
||
<td>NC_000009.11 (15464064..15510968, complement) </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<p class="withnote margin_t2em"><strong>Chromosome 9 - NC_000009.12</strong><img usemap="#nbrMap11168_568815589" border="0" alt="Genomic Context describing neighboring genes" src="/gutils/geneneighb.fcgi?geneid=11168&nuc_gi=568815589&n0=RPL7P33&n1=LOC127814451&n2=LOC130001563&n3=SNAPC3&n4=LOC130001564&n5=RNU6-319P&n6=PSIP1&n7=LOC127814452&n8=LOC127814453&n9=LOC127814454&n10=LOC107987048&n11=RN7SL98P" /><map name="nbrMap11168_568815589" id="nbrMap11168_568815589">
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ribosomal protein L7 pseudogene 33')" onMouseOut="hidetip()" coords="27,23,72,31" alt="Neighboring gene ribosomal protein L7 pseudogene 33" href="/gene/286348" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'H3K27ac hESC enhancer GRCh37_chr9:15418920-15419420')" onMouseOut="hidetip()" coords="127,23,197,31" alt="Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:15418920-15419420" href="/gene/127814451" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid silent region 19780')" onMouseOut="hidetip()" coords="135,35,205,43" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19780" href="/gene/130001563" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'ATAC-STARR-seq lymphoblastoid active region 28214')" onMouseOut="hidetip()" coords="137,47,207,55" alt="Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28214" href="/gene/130001564" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'small nuclear RNA activating complex polypeptide 3')" onMouseOut="hidetip()" coords="166,59,294,67" alt="Neighboring gene small nuclear RNA activating complex polypeptide 3" href="/gene/6619" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'RNA, U6 small nuclear 319, pseudogene')" onMouseOut="hidetip()" coords="171,71,226,79" alt="Neighboring gene RNA, U6 small nuclear 319, pseudogene" href="/gene/106481280" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:15510081-15511034')" onMouseOut="hidetip()" coords="326,35,396,43" alt="Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:15510081-15511034" href="/gene/127814452" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:15511035-15511987')" onMouseOut="hidetip()" coords="328,47,398,55" alt="Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:15511035-15511987" href="/gene/127814453" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:15512640-15513258')" onMouseOut="hidetip()" coords="332,59,402,67" alt="Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:15512640-15513258" href="/gene/127814454" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'thymosin beta-11-like')" onMouseOut="hidetip()" coords="353,71,423,79" alt="Neighboring gene thymosin beta-11-like" href="/gene/107987048" />
|
||
<area shape="rect" onMouseOver="showtip(this,event,'RNA, 7SL, cytoplasmic 98, pseudogene')" onMouseOut="hidetip()" coords="373,83,423,91" alt="Neighboring gene RNA, 7SL, cytoplasmic 98, pseudogene" href="/gene/106479259" />
|
||
</map>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-genomic-regions-transcripts-products">
|
||
<section class="rprt-section-header" id="genomic-regions-transcripts-products">
|
||
<h2 id="header-genomic-regions-transcripts-products">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-genomic-regions-transcripts-products .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Genomic regions, transcripts, and products</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Genomic_Regions_Transcripts_a" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<div style="text-align:right;">Go to <a href="#reference-sequences">reference sequence details</a></div>
|
||
</div>
|
||
<div>
|
||
<p class="choose">
|
||
<label for="accession" class="label">Genomic Sequence: </label>
|
||
<select name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.accessionList" sid="1" id="accessionList" data-taxid="9606" data-geneid="11168">
|
||
<option value="NC_000009.12_15464065_15510969">NC_000009.12 Chromosome 9 Reference GRCh38.p14 Primary Assembly</option>
|
||
<option value="NC_060933.1_15475997_15522881">NC_060933.1 Chromosome 9 Alternate T2T-CHM13v2.0</option>
|
||
<option value="NC_000009.11_15464063_15510967">NC_000009.11 Chromosome 9 Reference GRCh37.p13 Primary Assembly</option>
|
||
</select>
|
||
</p>
|
||
</div>
|
||
<div id="NC_000009" class="divAccession">
|
||
<div class="seq-viewer">
|
||
<p class="note-link">
|
||
<strong>Go to nucleotide:</strong>
|
||
<a title="Nucleotide Graphic report" href="/nuccore/NC_000009.12?report=graph&from=15457029&to=15518005&strand=true&app_context=Gene&assm_context=GCF_000001405.40" ref="ordinalpos=1&ncbi_uid=11168&link_uid=NC_000009.12">Graphics</a>
|
||
<a title="Nucleotide FASTA report" href="/nuccore/NC_000009.12?report=fasta&from=15464066&to=15510970&strand=true" ref="ordinalpos=1&ncbi_uid=11168&link_uid=NC_000009.12">FASTA</a>
|
||
<a title="Nucleotide GenBank report" href="/nuccore/NC_000009.12?report=genbank&from=15464066&to=15510970&strand=true" ref="ordinalpos=1&ncbi_uid=11168&link_uid=NC_000009.12">GenBank</a>
|
||
</p>
|
||
<div id="divNC_000009" class="SeqViewerApp" style="clear:both;" data-sv="appname=ncbigene&embedded=true&noslider=1&id=NC_000009.12&from=15457029&to=15518005&strand=true&app_context=Gene&assm_context=GCF_000001405.40">
|
||
<a href="?appname=ncbigene&embedded=true&noslider=1&id=NC_000009.12&from=15457029&to=15518005&strand=true&app_context=Gene&assm_context=GCF_000001405.40"></a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000009.12" sid="1" type="hidden" id="nucleotideLink_NC_000009_12_15464065_15510969" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_000009.12?report=graph&amp;from=15457029&amp;to=15518005&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" ref="ordinalpos=1&amp;ncbi_uid=11168&amp;link_uid=NC_000009.12">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_000009.12?report=fasta&amp;from=15464066&amp;to=15510970&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=11168&amp;link_uid=NC_000009.12">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_000009.12?report=genbank&amp;from=15464066&amp;to=15510970&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=11168&amp;link_uid=NC_000009.12">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000009.12" sid="1" type="hidden" id="relString_NC_000009_12_15464065_15510969" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000009.12&amp;from=15457029&amp;to=15518005&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.40" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_060933.1" sid="1" type="hidden" id="nucleotideLink_NC_060933_1_15475997_15522881" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_060933.1?report=graph&amp;from=15468964&amp;to=15529914&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_009914755.1" ref="ordinalpos=1&amp;ncbi_uid=11168&amp;link_uid=NC_060933.1">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_060933.1?report=fasta&amp;from=15475998&amp;to=15522882&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=11168&amp;link_uid=NC_060933.1">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_060933.1?report=genbank&amp;from=15475998&amp;to=15522882&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=11168&amp;link_uid=NC_060933.1">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_060933.1" sid="1" type="hidden" id="relString_NC_060933_1_15475997_15522881" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_060933.1&amp;from=15468964&amp;to=15529914&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_009914755.1" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.nucleotideLink_NC_000009.11" sid="1" type="hidden" id="nucleotideLink_NC_000009_11_15464063_15510967" value="<p class="note-link"><strong>Go to nucleotide:</strong><a title="Nucleotide Graphic report" href="/nuccore/NC_000009.11?report=graph&amp;from=15457027&amp;to=15518003&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" ref="ordinalpos=1&amp;ncbi_uid=11168&amp;link_uid=NC_000009.11">Graphics</a><a title="Nucleotide FASTA report" href="/nuccore/NC_000009.11?report=fasta&amp;from=15464064&amp;to=15510968&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=11168&amp;link_uid=NC_000009.11">FASTA</a><a title="Nucleotide GenBank report" href="/nuccore/NC_000009.11?report=genbank&amp;from=15464064&amp;to=15510968&amp;strand=true" ref="ordinalpos=1&amp;ncbi_uid=11168&amp;link_uid=NC_000009.11">GenBank</a></p>" />
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_GenomicProductsP.relString_NC_000009.11" sid="1" type="hidden" id="relString_NC_000009_11_15464063_15510967" value="appname=ncbigene&amp;embedded=true&amp;noslider=1&amp;id=NC_000009.11&amp;from=15457027&amp;to=15518003&amp;strand=true&amp;app_context=Gene&amp;assm_context=GCF_000001405.25" />
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-gene-expression">
|
||
<section class="rprt-section-header" id="gene-expression">
|
||
<h2 id="header-gene-expression">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-gene-expression .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Expression</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Expression" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<div style="text-align:right;">
|
||
<a href="/gene/11168/?report=expression" data-url="/gene/11168/?report=expression" id="gene-expression-see-details">See details</a>
|
||
</div>
|
||
<div id="gene-expression-app" data-url="https://www.ncbi.nlm.nih.gov/gene/11168" data-report-type="summary">
|
||
<div>
|
||
<script type="text/javascript">
|
||
|
||
window.tissues_data = {'adrenal 10wk': {'id': '11168_Adrenal_10wk_PRJNA270632', 'gene': 11168, 'source_name': 'adrenal 10wk', 'full_rpkm': 7.31212, 'exp_rpkm': 7.31, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734416836853785}, 'adrenal 16wk': {'id': '11168_Adrenal_16wk_PRJNA270632', 'gene': 11168, 'source_name': 'adrenal 16wk', 'full_rpkm': 3.74726, 'exp_rpkm': 3.75, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734416836853786}, 'adrenal 18wk': {'id': '11168_Adrenal_18wk_PRJNA270632', 'gene': 11168, 'source_name': 'adrenal 18wk', 'full_rpkm': 5.02989, 'exp_rpkm': 5.03, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734416836853787}, 'adrenal 20wk': {'id': '11168_Adrenal_20wk_PRJNA270632', 'gene': 11168, 'source_name': 'adrenal 20wk', 'full_rpkm': 3.20423, 'exp_rpkm': 3.2, 'var': 0.1706688, 'project_desc': 'PRJNA270632', '_version_': 1785734416836853788}, 'heart 10wk': {'id': '11168_Heart_10wk;_PRJNA270632', 'gene': 11168, 'source_name': 'heart 10wk', 'full_rpkm': 14.8192, 'exp_rpkm': 14.8, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734416836853789}, 'heart 11wk': {'id': '11168_Heart_11wk;_PRJNA270632', 'gene': 11168, 'source_name': 'heart 11wk', 'full_rpkm': 8.45209, 'exp_rpkm': 8.45, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902336}, 'heart 17wk': {'id': '11168_Heart_17wk;_PRJNA270632', 'gene': 11168, 'source_name': 'heart 17wk', 'full_rpkm': 6.9693, 'exp_rpkm': 6.97, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902337}, 'heart 18wk': {'id': '11168_Heart_18wk;_PRJNA270632', 'gene': 11168, 'source_name': 'heart 18wk', 'full_rpkm': 6.67435, 'exp_rpkm': 6.67, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902338}, 'heart 20wk': {'id': '11168_Heart_20wk_PRJNA270632', 'gene': 11168, 'source_name': 'heart 20wk', 'full_rpkm': 7.13594, 'exp_rpkm': 7.14, 'var': 6.11391, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902339}, 'intestine 10wk': {'id': '11168_Intestine_10wk_PRJNA270632', 'gene': 11168, 'source_name': 'intestine 10wk', 'full_rpkm': 10.8197, 'exp_rpkm': 10.8, 'var': 10.4538, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902340}, 'intestine 11wk': {'id': '11168_Intestine_11wk_PRJNA270632', 'gene': 11168, 'source_name': 'intestine 11wk', 'full_rpkm': 10.5783, 'exp_rpkm': 10.6, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902341}, 'intestine 15wk': {'id': '11168_Intestine_15wk_PRJNA270632', 'gene': 11168, 'source_name': 'intestine 15wk', 'full_rpkm': 7.51059, 'exp_rpkm': 7.51, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902342}, 'intestine 17wk': {'id': '11168_Intestine_17wk_PRJNA270632', 'gene': 11168, 'source_name': 'intestine 17wk', 'full_rpkm': 4.48758, 'exp_rpkm': 4.49, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902343}, 'intestine 20wk': {'id': '11168_Intestine_20wk_PRJNA270632', 'gene': 11168, 'source_name': 'intestine 20wk', 'full_rpkm': 9.30232, 'exp_rpkm': 9.3, 'var': 0.331756, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902344}, 'kidney 10wk': {'id': '11168_Kidney_10wk_PRJNA270632', 'gene': 11168, 'source_name': 'kidney 10wk', 'full_rpkm': 13.6776, 'exp_rpkm': 13.7, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902345}, 'kidney 16wk': {'id': '11168_Kidney_16wk_PRJNA270632', 'gene': 11168, 'source_name': 'kidney 16wk', 'full_rpkm': 4.97398, 'exp_rpkm': 4.97, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902346}, 'kidney 20wk': {'id': '11168_Kidney_20wk_PRJNA270632', 'gene': 11168, 'source_name': 'kidney 20wk', 'full_rpkm': 1.91003, 'exp_rpkm': 1.91, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902347}, 'lung 10wk': {'id': '11168_Lung_10wk_PRJNA270632', 'gene': 11168, 'source_name': 'lung 10wk', 'full_rpkm': 12.7681, 'exp_rpkm': 12.8, 'var': 0.1096316, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902348}, 'lung 17wk': {'id': '11168_Lung_17wk_PRJNA270632', 'gene': 11168, 'source_name': 'lung 17wk', 'full_rpkm': 11.8327, 'exp_rpkm': 11.8, 'var': 0.883284, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902349}, 'lung 20wk': {'id': '11168_Lung_20wk_PRJNA270632', 'gene': 11168, 'source_name': 'lung 20wk', 'full_rpkm': 8.25378, 'exp_rpkm': 8.25, 'var': 5.26806, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902350}, 'stomach 10wk': {'id': '11168_Stomach_10wk_PRJNA270632', 'gene': 11168, 'source_name': 'stomach 10wk', 'full_rpkm': 7.17863, 'exp_rpkm': 7.18, 'var': 0.371088, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902351}, 'stomach 16wk': {'id': '11168_Stomach_16wk_PRJNA270632', 'gene': 11168, 'source_name': 'stomach 16wk', 'full_rpkm': 10.0057, 'exp_rpkm': 10.0, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902352}, 'stomach 18wk': {'id': '11168_Stomach_18wk_PRJNA270632', 'gene': 11168, 'source_name': 'stomach 18wk', 'full_rpkm': 10.083, 'exp_rpkm': 10.1, 'var': 0.0, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902353}, 'stomach 20wk': {'id': '11168_Stomach_20wk_PRJNA270632', 'gene': 11168, 'source_name': 'stomach 20wk', 'full_rpkm': 9.95401, 'exp_rpkm': 9.95, 'var': 0.35034, 'project_desc': 'PRJNA270632', '_version_': 1785734416837902354}};
|
||
|
||
|
||
|
||
|
||
window.details_data = {"adrenal 10wk": [{"id": "metadata_9606_SAMN03267754", "gene": 11168, "sample_id": "SAMN03267754", "full_rpkm": 7.31212, "exp_rpkm": 7.31, "exp_total": 188213, "project_desc": "PRJNA270632", "_version_": 1785734387345653765, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 10wk", "exp_Mcount": 4852.92}], "adrenal 16wk": [{"id": "metadata_9606_SAMN03267755", "gene": 11168, "sample_id": "SAMN03267755", "full_rpkm": 3.74726, "exp_rpkm": 3.75, "exp_total": 144481, "project_desc": "PRJNA270632", "_version_": 1785734387345653764, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 16wk", "exp_Mcount": 7269.31}], "adrenal 18wk": [{"id": "metadata_9606_SAMN03267761", "gene": 11168, "sample_id": "SAMN03267761", "full_rpkm": 5.02989, "exp_rpkm": 5.03, "exp_total": 178090, "project_desc": "PRJNA270632", "_version_": 1785734387345653763, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 18wk", "exp_Mcount": 6675.41}], "adrenal 20wk": [{"id": "metadata_9606_SAMN03267762", "gene": 11168, "sample_id": "SAMN03267762", "full_rpkm": 3.61735, "exp_rpkm": 3.62, "exp_total": 145083, "project_desc": "PRJNA270632", "_version_": 1785734387345653761, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 20wk", "exp_Mcount": 7561.75}, {"id": "metadata_9606_SAMN03267753", "gene": 11168, "sample_id": "SAMN03267753", "full_rpkm": 2.79111, "exp_rpkm": 2.79, "exp_total": 98417, "project_desc": "PRJNA270632", "_version_": 1785734387345653762, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "adrenal 20wk", "exp_Mcount": 6647.98}], "heart 10wk": [{"id": "metadata_9606_SAMN03267750", "gene": 11168, "sample_id": "SAMN03267750", "full_rpkm": 14.8192, "exp_rpkm": 14.8, "exp_total": 419741, "project_desc": "PRJNA270632", "_version_": 1785734387345653760, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 10wk", "exp_Mcount": 5340.16}], "heart 11wk": [{"id": "metadata_9606_SAMN03267763", "gene": 11168, "sample_id": "SAMN03267763", "full_rpkm": 8.45209, "exp_rpkm": 8.45, "exp_total": 266159, "project_desc": "PRJNA270632", "_version_": 1785734387344605210, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 11wk", "exp_Mcount": 5937.09}], "heart 17wk": [{"id": "metadata_9606_SAMN03267757", "gene": 11168, "sample_id": "SAMN03267757", "full_rpkm": 6.9693, "exp_rpkm": 6.97, "exp_total": 292308, "project_desc": "PRJNA270632", "_version_": 1785734387344605209, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 17wk", "exp_Mcount": 7907.66}], "heart 18wk": [{"id": "metadata_9606_SAMN03267751", "gene": 11168, "sample_id": "SAMN03267751", "full_rpkm": 6.67435, "exp_rpkm": 6.67, "exp_total": 225889, "project_desc": "PRJNA270632", "_version_": 1785734387344605208, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 18wk", "exp_Mcount": 6380.91}], "heart 20wk": [{"id": "metadata_9606_SAMN03267756", "gene": 11168, "sample_id": "SAMN03267756", "full_rpkm": 5.34739, "exp_rpkm": 5.35, "exp_total": 307916, "project_desc": "PRJNA270632", "_version_": 1785734387344605205, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 20wk", "exp_Mcount": 10856.4}, {"id": "metadata_9606_SAMN03267764", "gene": 11168, "sample_id": "SAMN03267764", "full_rpkm": 10.6325, "exp_rpkm": 10.6, "exp_total": 287475, "project_desc": "PRJNA270632", "_version_": 1785734387344605206, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 20wk", "exp_Mcount": 5097.56}, {"id": "metadata_9606_SAMN03267760", "gene": 11168, "sample_id": "SAMN03267760", "full_rpkm": 5.42798, "exp_rpkm": 5.43, "exp_total": 172569, "project_desc": "PRJNA270632", "_version_": 1785734387344605207, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "heart 20wk", "exp_Mcount": 5994.06}], "intestine 10wk": [{"id": "metadata_9606_SAMN03267752", "gene": 11168, "sample_id": "SAMN03267752", "full_rpkm": 7.58648, "exp_rpkm": 7.59, "exp_total": 314216, "project_desc": "PRJNA270632", "_version_": 1785734387344605203, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 10wk", "exp_Mcount": 7808.8}, {"id": "metadata_9606_SAMN03267759", "gene": 11168, "sample_id": "SAMN03267759", "full_rpkm": 14.0529, "exp_rpkm": 14.1, "exp_total": 514814, "project_desc": "PRJNA270632", "_version_": 1785734387344605204, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 10wk", "exp_Mcount": 6906.84}], "intestine 11wk": [{"id": "metadata_9606_SAMN03267758", "gene": 11168, "sample_id": "SAMN03267758", "full_rpkm": 10.5783, "exp_rpkm": 10.6, "exp_total": 243220, "project_desc": "PRJNA270632", "_version_": 1785734387344605202, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 11wk", "exp_Mcount": 4334.9}], "intestine 15wk": [{"id": "metadata_9606_SAMN03267775", "gene": 11168, "sample_id": "SAMN03267775", "full_rpkm": 7.51059, "exp_rpkm": 7.51, "exp_total": 158566, "project_desc": "PRJNA270632", "_version_": 1785734387344605201, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 15wk", "exp_Mcount": 3980.45}], "intestine 17wk": [{"id": "metadata_9606_SAMN03267782", "gene": 11168, "sample_id": "SAMN03267782", "full_rpkm": 4.48758, "exp_rpkm": 4.49, "exp_total": 230063, "project_desc": "PRJNA270632", "_version_": 1785734387344605200, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 17wk", "exp_Mcount": 9665.65}], "intestine 20wk": [{"id": "metadata_9606_SAMN03267766", "gene": 11168, "sample_id": "SAMN03267766", "full_rpkm": 9.8783, "exp_rpkm": 9.88, "exp_total": 218027, "project_desc": "PRJNA270632", "_version_": 1785734387344605198, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 20wk", "exp_Mcount": 4161.26}, {"id": "metadata_9606_SAMN03267769", "gene": 11168, "sample_id": "SAMN03267769", "full_rpkm": 8.72633, "exp_rpkm": 8.73, "exp_total": 180232, "project_desc": "PRJNA270632", "_version_": 1785734387344605199, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "intestine 20wk", "exp_Mcount": 3894.01}], "kidney 10wk": [{"id": "metadata_9606_SAMN03267784", "gene": 11168, "sample_id": "SAMN03267784", "full_rpkm": 13.6776, "exp_rpkm": 13.7, "exp_total": 342822, "project_desc": "PRJNA270632", "_version_": 1785734387344605197, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 10wk", "exp_Mcount": 4725.59}], "kidney 16wk": [{"id": "metadata_9606_SAMN03267772", "gene": 11168, "sample_id": "SAMN03267772", "full_rpkm": 4.97398, "exp_rpkm": 4.97, "exp_total": 403333, "project_desc": "PRJNA270632", "_version_": 1785734387344605196, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 16wk", "exp_Mcount": 15288.2}], "kidney 20wk": [{"id": "metadata_9606_SAMN03267777", "gene": 11168, "sample_id": "SAMN03267777", "full_rpkm": 1.91003, "exp_rpkm": 1.91, "exp_total": 104145, "project_desc": "PRJNA270632", "_version_": 1785734387344605195, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "kidney 20wk", "exp_Mcount": 10280.0}], "lung 10wk": [{"id": "metadata_9606_SAMN03267770", "gene": 11168, "sample_id": "SAMN03267770", "full_rpkm": 12.437, "exp_rpkm": 12.4, "exp_total": 392677, "project_desc": "PRJNA270632", "_version_": 1785734387344605193, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 10wk", "exp_Mcount": 5952.75}, {"id": "metadata_9606_SAMN03267767", "gene": 11168, "sample_id": "SAMN03267767", "full_rpkm": 13.0992, "exp_rpkm": 13.1, "exp_total": 363458, "project_desc": "PRJNA270632", "_version_": 1785734387344605194, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 10wk", "exp_Mcount": 5231.26}], "lung 17wk": [{"id": "metadata_9606_SAMN03267778", "gene": 11168, "sample_id": "SAMN03267778", "full_rpkm": 10.8928, "exp_rpkm": 10.9, "exp_total": 361342, "project_desc": "PRJNA270632", "_version_": 1785734387344605191, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 17wk", "exp_Mcount": 6254.23}, {"id": "metadata_9606_SAMN03267776", "gene": 11168, "sample_id": "SAMN03267776", "full_rpkm": 12.7725, "exp_rpkm": 12.8, "exp_total": 253593, "project_desc": "PRJNA270632", "_version_": 1785734387344605192, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 17wk", "exp_Mcount": 3743.33}], "lung 20wk": [{"id": "metadata_9606_SAMN03267780", "gene": 11168, "sample_id": "SAMN03267780", "full_rpkm": 5.95856, "exp_rpkm": 5.96, "exp_total": 292975, "project_desc": "PRJNA270632", "_version_": 1785734387344605189, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 20wk", "exp_Mcount": 9270.13}, {"id": "metadata_9606_SAMN03267768", "gene": 11168, "sample_id": "SAMN03267768", "full_rpkm": 10.549, "exp_rpkm": 10.5, "exp_total": 355437, "project_desc": "PRJNA270632", "_version_": 1785734387344605190, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "lung 20wk", "exp_Mcount": 6352.54}], "stomach 10wk": [{"id": "metadata_9606_SAMN03267773", "gene": 11168, "sample_id": "SAMN03267773", "full_rpkm": 7.7878, "exp_rpkm": 7.79, "exp_total": 271880, "project_desc": "PRJNA270632", "_version_": 1785734387344605187, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 10wk", "exp_Mcount": 6582.02}, {"id": "metadata_9606_SAMN03267779", "gene": 11168, "sample_id": "SAMN03267779", "full_rpkm": 6.56946, "exp_rpkm": 6.57, "exp_total": 252065, "project_desc": "PRJNA270632", "_version_": 1785734387344605188, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 10wk", "exp_Mcount": 7234.02}], "stomach 16wk": [{"id": "metadata_9606_SAMN03267774", "gene": 11168, "sample_id": "SAMN03267774", "full_rpkm": 10.0057, "exp_rpkm": 10.0, "exp_total": 330065, "project_desc": "PRJNA270632", "_version_": 1785734387344605186, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 16wk", "exp_Mcount": 6219.43}], "stomach 18wk": [{"id": "metadata_9606_SAMN03267771", "gene": 11168, "sample_id": "SAMN03267771", "full_rpkm": 10.083, "exp_rpkm": 10.1, "exp_total": 311278, "project_desc": "PRJNA270632", "_version_": 1785734387344605185, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 18wk", "exp_Mcount": 5820.42}], "stomach 20wk": [{"id": "metadata_9606_SAMN03267765", "gene": 11168, "sample_id": "SAMN03267765", "full_rpkm": 10.2456, "exp_rpkm": 10.2, "exp_total": 244247, "project_desc": "PRJNA270632", "_version_": 1785734387342508032, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4494.58}, {"id": "metadata_9606_SAMN03267781", "gene": 11168, "sample_id": "SAMN03267781", "full_rpkm": 10.4877, "exp_rpkm": 10.5, "exp_total": 254006, "project_desc": "PRJNA270632", "_version_": 1785734387343556608, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4566.24}, {"id": "metadata_9606_SAMN03267783", "gene": 11168, "sample_id": "SAMN03267783", "full_rpkm": 9.1287, "exp_rpkm": 9.13, "exp_total": 232631, "project_desc": "PRJNA270632", "_version_": 1785734387344605184, "is_metadata": true, "is_sample": true, "taxid": 9606, "source_name": "stomach 20wk", "exp_Mcount": 4804.58}]}
|
||
window.taxId = 9606
|
||
</script>
|
||
|
||
|
||
<div>
|
||
|
||
|
||
|
||
<select name="p" id="project-selector">
|
||
|
||
|
||
<option value="SRP051249" selected="selected" data-bioproject="PRJNA270632">
|
||
|
||
Tissue-specific circular RNA induction during human fetal development
|
||
|
||
</option>
|
||
|
||
|
||
|
||
<option value="SRP056969" data-bioproject="PRJNA280600">
|
||
|
||
RNA sequencing of total RNA from 20 human tissues
|
||
|
||
|
||
</option>
|
||
|
||
|
||
|
||
<option value="ERP003613" data-bioproject="PRJEB4337">
|
||
|
||
HPA RNA-seq normal tissues
|
||
|
||
|
||
</option>
|
||
|
||
|
||
|
||
</select>
|
||
|
||
|
||
|
||
<ul id="project-summary">
|
||
<li id="project-summary-title">Project title:
|
||
|
||
Tissue-specific circular RNA induction during human fetal development
|
||
|
||
</li>
|
||
|
||
|
||
<li id="project-summary-desc">Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA</li>
|
||
|
||
|
||
|
||
<li id="project-summary-bioprojects">BioProject: <a href="/bioproject/PRJNA270632/">PRJNA270632</a>
|
||
</li>
|
||
|
||
<li id="project-summary-pubs">Publication:
|
||
|
||
|
||
<span><a href="/pubmed/26076956/">PMID 26076956</a></span>
|
||
|
||
</li>
|
||
|
||
|
||
<li id="project-summary-analysis-date">Analysis date: Mon Apr 2 22:54:59 2018</li>
|
||
|
||
</ul>
|
||
|
||
|
||
|
||
<div id="gene-expr-details" class="expression-chart"></div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<script type="text/javascript" src="https://www.gstatic.com/charts/loader.js"></script>
|
||
<script type="text/javascript">
|
||
google.charts.load('current', {
|
||
'packages':[ 'corechart']
|
||
});
|
||
|
||
</script>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-bibliography">
|
||
<section class="rprt-section-header" id="bibliography"><h2 id="header-bibliography"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-bibliography .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Bibliography</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Bibliography" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
|
||
<div class="rprt-section-body" style="">
|
||
<div class="generif-pubmed">
|
||
<h3 id="relatedarticlesinpubmed">
|
||
<a href="#" class="jig-ncbitoggler-open">Related articles in PubMed</a>
|
||
</h3>
|
||
<div class="generefbl-link">
|
||
<ol class="generef-link">
|
||
<li>
|
||
<a href="/pubmed/21623867/" ref="ordinalpos=1&ncbi_uid=11168&link_uid=21623867">Diagnostic utility of low-affinity nerve growth factor receptor (P 75) immunostaining in atypical fibroxanthoma.</a>
|
||
<span class="pubmed-auth-date"> Bull C, <em>et al</em>. J Cutan Pathol, 2011 Aug. PMID 21623867</span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/24604027/" ref="ordinalpos=2&ncbi_uid=11168&link_uid=24604027">Oncogenic human papillomaviruses activate the tumor-associated lens epithelial-derived growth factor (LEDGF) gene.</a>
|
||
<span class="pubmed-auth-date"> Leitz J, <em>et al</em>. PLoS Pathog, 2014 Mar. PMID 24604027, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC3946365/" ref="ordinalpos=0&ncbi_uid=11168&link_uid=PMC3946365">Free PMC Article</a></span></span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/28212536/" ref="ordinalpos=3&ncbi_uid=11168&link_uid=28212536">Targeting the stress oncoprotein LEDGF/p75 to sensitize chemoresistant prostate cancer cells to taxanes.</a>
|
||
<span class="pubmed-auth-date"> Ríos-Colón L, <em>et al</em>. Oncotarget, 2017 Apr 11. PMID 28212536, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC5421899/" ref="ordinalpos=0&ncbi_uid=11168&link_uid=PMC5421899">Free PMC Article</a></span></span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/28770702/" ref="ordinalpos=4&ncbi_uid=11168&link_uid=28770702">Prevalence of anti-DFS70 antibodies in patients with and without systemic autoimmune rheumatic diseases.</a>
|
||
<span class="pubmed-auth-date"> Shovman O, <em>et al</em>. Clin Exp Rheumatol, 2018 Jan-Feb. PMID 28770702</span>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/34685704/" ref="ordinalpos=5&ncbi_uid=11168&link_uid=34685704">The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells.</a>
|
||
<span class="pubmed-auth-date"> Ortiz-Hernandez GL, <em>et al</em>. Cells, 2021 Oct 12. PMID 34685704, <span class="pubmed-pmc-link"><a href="/pmc/articles/PMC8534522/" ref="ordinalpos=0&ncbi_uid=11168&link_uid=PMC8534522">Free PMC Article</a></span></span>
|
||
</li>
|
||
</ol>
|
||
<p class="see-all-pm">
|
||
<a href="/pubmed?LinkName=gene_pubmed&from_uid=11168" title="See all 365 citations in Pubmed">See all (365) citations in PubMed</a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="generif-pubmed generif">
|
||
<h3 id="generifsgenereferencesintofunctions">
|
||
<a href="#" class="jig-ncbitoggler-open">GeneRIFs: Gene References Into Functions</a>
|
||
</h3>
|
||
<div>
|
||
<a href="/gene/about-generif" class="whatisthis">What's a GeneRIF?</a>
|
||
<div class="generefbl-link">
|
||
<ol class="generef-link">
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/38191578" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=11168&link_uid=38191578">PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity.</a>
|
||
<div id="gene-popper1" class="gene-rif-popper">Title: PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/34225636" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=11168&link_uid=34225636">The LncRNA MIR155HG is Upregulated by SP1 in Melanoma Cells and Drives Melanoma Progression via Modulating the MiR-485-3p/PSIP1 Axis.</a>
|
||
<div id="gene-popper2" class="gene-rif-popper">Title: The LncRNA MIR155HG is Upregulated by SP1 in Melanoma Cells and Drives Melanoma Progression via Modulating the MiR-485-3p/PSIP1 Axis.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/34634812" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=11168&link_uid=34634812">Modulation of the intrinsic chromatin binding property of HIV-1 integrase by LEDGF/p75.</a>
|
||
<div id="gene-popper3" class="gene-rif-popper">Title: Modulation of the intrinsic chromatin binding property of HIV-1 integrase by LEDGF/p75.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/34685704" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=11168&link_uid=34685704">The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells.</a>
|
||
<div id="gene-popper4" class="gene-rif-popper">Title: The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/34070855" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=11168&link_uid=34070855">LEDGF/p75 Is Required for an Efficient DNA Damage Response.</a>
|
||
<div id="gene-popper5" class="gene-rif-popper">Title: LEDGF/p75 Is Required for an Efficient DNA Damage Response.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/33477970" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=11168&link_uid=33477970">Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival.</a>
|
||
<div id="gene-popper6" class="gene-rif-popper">Title: Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/30787394" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=11168&link_uid=30787394">Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection.</a>
|
||
<div id="gene-popper7" class="gene-rif-popper">Title: Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/31616795" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=11168&link_uid=31616795">LEDGF and HDGF2 colocalize with Histone H3 lysine 36 methylation 2/3 at genomic regions containing active genes.</a>
|
||
<div id="gene-popper8" class="gene-rif-popper">Title: LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/31819277" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=11168&link_uid=31819277">This study reports the cryo-electron microscopy structure of the PWWP reader domain of human transcriptional coactivator LEDGF in complex with an H3K36-methylated nucleosome at 3.2-A resolution.</a>
|
||
<div id="gene-popper9" class="gene-rif-popper">Title: Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding.</div>
|
||
</li>
|
||
<li class="gene-rif-popper">
|
||
<a href="/pubmed/31396837" target="_blank" class="gene-rif-popper" ref="ordinalpos=1&ncbi_uid=11168&link_uid=31396837">antibodies more frequent in systemic autoimmune rheumatic disease patients than in blood donors</a>
|
||
<div id="gene-popper10" class="gene-rif-popper">Title: Investigation of anti-DFS70 antibody in patients with systemic autoimmune rheumatic diseases.</div>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
<div class="submit-genrif">
|
||
<span>Submit:</span>
|
||
<a href="/gene/submit-generif/?geneId=11168&sym=PSIP1&name=PC4 and SRSF1 interacting protein 1&org=Homo sapiens">New GeneRIF</a>
|
||
<a href="/RefSeq/update.cgi?geneid=11168&symbol=PSIP1;task=fixpub">Correction</a>
|
||
<a href="https://www.ncbi.nlm.nih.gov/gene?db=gene&report=generif&term=11168" class="seeall-generif">See all GeneRIFs (107)</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-phenotypes">
|
||
<section class="rprt-section-header" id="phenotypes">
|
||
<h2 id="header-phenotypes">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-phenotypes .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Phenotypes</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Phenotype" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body info-phenotype">
|
||
<p class="nochild-link">
|
||
<a href="/gtr/tests/?term=PSIP1[gene]">Find tests for this gene in the NIH Genetic Testing Registry (GTR)</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/gap/PheGenI?tab=1&gene=11168">Review eQTL and phenotype association data in this region using PheGenI</a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-variation">
|
||
<section class="rprt-section-header" id="variation">
|
||
<h2 id="header-variation">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-variation .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Variation</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.variation" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<p class="nochild-link">
|
||
<a href="/clinvar/?term=PSIP1[gene]" ref="log$=recordlinks">See variants in ClinVar</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/dbvar?LinkName=gene_dbvar&from_uid=11168" ref="log$=recordlinks">See studies and variants in dbVar</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/variation/view/?q=11168[geneid]&assm=GCF_000001405.25" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh37.p13)">See Variation Viewer (GRCh37.p13)</a>
|
||
</p>
|
||
<p class="nochild-link">
|
||
<a href="/variation/view/?q=11168[geneid]" ref="log$=recordlinks" data-genome-browser-link-sort="3" class="genome-browser-link" data-gblink-text="Variation Viewer (GRCh38)">See Variation Viewer (GRCh38)</a>
|
||
</p>
|
||
<set></set>
|
||
<set></set>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-HIV-1-interactions">
|
||
<section class="rprt-section-header" id="HIV-1-interactions">
|
||
<h2 id="header-HIV-1-interactions">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-HIV-1-interactions .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">HIV-1 interactions</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.HIV1_interactions" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div class="fgrid">
|
||
<h3 id="replicationinteractions">Replication interactions</h3>
|
||
<table summary="replication interactions" class="jig-ncbigrid">
|
||
<thead>
|
||
<tr>
|
||
<th id="hivinter">Interaction</th>
|
||
<th id="hivpub">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="hivinter">HIV-1 LAI replication requires PSIP1 (LEDGF) and TNPO3 expression as shown through CRISPR/Cas9 genome editing in primary CD4+ T cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 27783955" href="/pubmed/27783955">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">HIV-1 replication, specifically reactivation, requires PSIP1 (LEDGF/p75) as shown through inhibition with LEDGINs</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 27428435" href="/pubmed/27428435">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">HIV-1 replication requires PSIP1 (LEDGF/p75) and TPR to maintain chromatin structure amenable to integration as shown through shRNA treatment</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25744187" href="/pubmed/25744187">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivinter">Knockdown of LEDGF/p75 by shRNA enhances HIV-1 replication in HIV-1-infected CD4+ T-cells and latently infected cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25590759" href="/pubmed/25590759">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
<h3 id="proteininteractions">Protein interactions</h3>
|
||
<table summary="protein interactions" class="jig-ncbigrid">
|
||
<thead>
|
||
<tr>
|
||
<th id="hivprotein">Protein</th>
|
||
<th id="gene-hivprotein">Gene</th>
|
||
<th id="hivinter">Interaction</th>
|
||
<th id="hivpub">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/28872823">Pol</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">LEDGF/p75 is recruited to HIV-1 particles through its direct interaction with the IN domain of Pol</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25809198" href="/pubmed/25809198">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Pol is identified to have a physical interaction with PC4 and SFRS1 interacting protein 1 (PSIP1; p75/LEDGF) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22190034" href="/pubmed/22190034">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/9629359">Rev</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155908">rev</a>
|
||
</td>
|
||
<td headers="hivinter">Rev 35-50, Rev 75-84, LEDGF 361-370, and LEDGF 402-411 peptides can specifically prevent formation of the Rev-LEDGF/p75 complex</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19855849" href="/pubmed/19855849">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155908">rev</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Rev interacts with LEDGF/p75 to promote dissociation of HIV-1 IN-LEDGF/p75 complex</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19855849" href="/pubmed/19855849">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/19172948">capsid</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">LEDGF/p75 is incorporated in HIV-1 particles, and fractionates with HIV-1 CA and IN viral proteins in velocity gradient purification assay</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25809198" href="/pubmed/25809198">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 CA mutant N74D and depletion of NUP153 and LEDGF/p75 significantly reduce HIV-1 DNA integration into gene-rich regions of chromosomes and gene bodies</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23097450" href="/pubmed/23097450">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155030">gag</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 CA mutants, including Q63A/Q67A, N74D, G89V, P90A, and A92E, are less dependent on LEDGF/p75 than the wild type CA in infectivity</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23097450" href="/pubmed/23097450">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/25121908">integrase</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Integrase interacts with PSIP1 (LEDGF/p75) to determine the site of integration</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 27428435" href="/pubmed/27428435">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">PSIP1 (LEDGF/p75) L368A mutant demonstrates reduced binding to HIV-1 IN</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26245978" href="/pubmed/26245978">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">PSIP1 (LEDGF/p75) K407D mutation increases binding to HIV-1 IN</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26245978" href="/pubmed/26245978">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">The IN catalytic core domain has a higher binding affinity (Kd) for PSIP1 (LEDGF/p75) than the physiological binding partners, CDCA7L (JOP2), POGZ, KMT2A (MML1) and IWS1</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26245978" href="/pubmed/26245978">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">The HIV IN interaction site on the PSIP1 (LEDGF/p75) intergrase binding domain (IBD) overlaps with that of POGZ, JPO2 and KMT2A (MLL1)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26245978" href="/pubmed/26245978">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">A domesticated transposase, POGZ, carries a DDE domain (amino acids 1117-1323) and interacts with LEDGF/p75. HIV-1 IN is efficient in displacing POGZ from LEDGF/p75</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26245978,19244240" href="/pubmed/26245978,19244240">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">The interaction of HIV-1 integrase with LEDGF/p75 accounts for the karyophilic properties and chromosomal targeting of integrase, which co-localizes with LEDGF/p75 in the nuclei of human cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26245978,25555456,25383358,25147212,24820090,24618511,24451643,24051001,23863879,23859152,23024700,22928108,22762018,22535962,22291694,21994603,21270171,20538907,19836475,19389610,19232540,19020832,19020831,18369482,18264802,17669426,17320002,17304248,16793062,16403635,15788449,15308744,12796494,12407101" href="/pubmed/26245978,25555456,25383358,25147212,24820090,24618511,24451643,24051001,23863879,23859152,23024700,22928108,22762018,22535962,22291694,21994603,21270171,20538907,19836475,19389610,19232540,19020832,19020831,18369482,18264802,17669426,17320002,17304248,16793062,16403635,15788449,15308744,12796494,12407101">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">LEDGF/p75 complexes with HIV-1 integrase and stimulates integrase strand transfer activity in vitro</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 26245978,25778682,25705574,25555456,25322565,25147212,25118283,25072705,24874515,24794743,24451643,24261564,24014475,23994868,23985689,23863879,23803661,23799881,23758584,23671082,23610442,23445471,23306052,23217620,23043109,23024700,22928108,22762018,22733274,22437836,22421880,22291694,22278243,21994603,21994569,21875413,21771857,21506277,21409951,21222490,21152581,20974633,20850978,20719241,20712566,20538907,20473303,20367881,20018238,20016921,19889764,19855849,19836475,19801648,19750561,19609362,19609359,19565598,19389610,19244240,19229293,19132083,19081927,19049878,19020831,19015031,19014595,18799576,18789977,18691555,18369482,18264802,18174227,17669426,17488811,17328897,17320002,17298035,17267486,17258258,17172465,17158150,17083721,16403635,12796494,12407101" href="/pubmed/26245978,25778682,25705574,25555456,25322565,25147212,25118283,25072705,24874515,24794743,24451643,24261564,24014475,23994868,23985689,23863879,23803661,23799881,23758584,23671082,23610442,23445471,23306052,23217620,23043109,23024700,22928108,22762018,22733274,22437836,22421880,22291694,22278243,21994603,21994569,21875413,21771857,21506277,21409951,21222490,21152581,20974633,20850978,20719241,20712566,20538907,20473303,20367881,20018238,20016921,19889764,19855849,19836475,19801648,19750561,19609362,19609359,19565598,19389610,19244240,19229293,19132083,19081927,19049878,19020831,19015031,19014595,18799576,18789977,18691555,18369482,18264802,18174227,17669426,17488811,17328897,17320002,17298035,17267486,17258258,17172465,17158150,17083721,16403635,12796494,12407101">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">LEDGF/p75 is incorporated in HIV-1 particles, and fractionates with HIV-1 CA and IN viral proteins in velocity gradient purification assay</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25809198" href="/pubmed/25809198">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">LEDGF/p75 is recruited to HIV-1 particles through its direct interaction with the IN domain of Pol</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25809198" href="/pubmed/25809198">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">LEDGINs are novel allosteric HIV-1 IN inhibitors, which inhibit the catalytic activity of IN, abrogate the interaction between LEDGF/p75 and IN, and enhance IN oligomerization in viral particles</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25778682,25555456,25486307,25224008,24618511,24480521,24451643,24389668,24261564,23859152,23721378,23671082,23610442" href="/pubmed/25778682,25555456,25486307,25224008,24618511,24480521,24451643,24389668,24261564,23859152,23721378,23671082,23610442">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 IN mutant K42E reduces its ability of binding to LEDGF/p75, whereas HIV-1 IN mutants EE10/13RR and EEE6/10/13RRE abolish to bind a detectable level of LEDGF/p75</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25383358" href="/pubmed/25383358">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Small molecules are identified to inhibit HIV-1 IN dimerization, IN/viral DNA assembly, and/or IN/LEDGF interaction</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25555456,25230778,25118283,24954548,24904063,24874515,24794743,24618511,23859152,22928108,22808106,22733274,22535962" href="/pubmed/25555456,25230778,25118283,24954548,24904063,24874515,24794743,24618511,23859152,22928108,22808106,22733274,22535962">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">(E)-3-(2-chlorophenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one (NPD170) shows the antiviral activity by blocking the binding of transfected IN to endogenous LEDGF/p75 in cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25555456,23046280" href="/pubmed/25555456,23046280">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">N-(cyclohexylmethyl)-2,3-dihydroxy-5-(piperidin-1-ylsulfonyl) benzamide (5u) inhibits the HIV-1 IN-LEDGF/p75 interaction</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25555456,21778063" href="/pubmed/25555456,21778063">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">2-(quinolin-3-yl) acetic acid derivatives inhibit the IN-LEDGF interaction in vitro and impair HIV-1 replication in infected cells.</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25555456,22664975,22437836,20473303" href="/pubmed/25555456,22664975,22437836,20473303">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Studies on integrase strand transfer activity in vitro show that LEDGF/p75 only binds HIV-1 integrase before the latter binds donor DNA, whereas donor DNA engages either free or LEDGF/p75-bound integrase</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25555456,22928108,19229293,19049878,18369482,18264802,17298035" href="/pubmed/25555456,22928108,19229293,19049878,18369482,18264802,17298035">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">LEDGF/p75 interferes with HIV-1 integrase (IN) full-site product formation by competing for HIV-1 IN dimer-dimer interactions or interfering with assembled synaptic complexes that harbor a single integrated end</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25555456,22928108,22762018,18369482,18264802,17258258" href="/pubmed/25555456,22928108,22762018,18369482,18264802,17258258">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">LEDGF strongly stabilizes HIV-1 integrase-LEDGF/p75 interactions and promotes IN tetramerization</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25555456,24904063,22928108,22762018,19229293,18801737" href="/pubmed/25555456,24904063,22928108,22762018,19229293,18801737">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">LEDGF/p75 binds to HIV-1 integrase (IN) and tethers IN to chromatin; the N-terminal PWWP domain (residues 1-93) in LEDGF/p75, and its beta-barrel substructure (first 63 residues) are required for chromatin binding and IN tethering to chromatin</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25555456,23043109,23024700,22928108,21510906,21506277,21152581,19401538,18799576,18369482,18264802,18174227,16959972,16793062" href="/pubmed/25555456,23043109,23024700,22928108,21510906,21506277,21152581,19401538,18799576,18369482,18264802,18174227,16959972,16793062">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">The N-terminal zinc binding domain (amino acids 1-52) and the central core domain (amino acids 53-212) of HIV-1 integrase are involved in the interaction with LEDGF/p75, with the core domain harboring the main determinant for interaction</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25462529,23863879,23043109,22928108,22190034,21778063,21506277,19609359,19401538,19132083,18801737,18480474,18369482,18264802,17158150,17137594,16403635,16075307,15875659,12796494" href="/pubmed/25462529,23863879,23043109,22928108,22190034,21778063,21506277,19609359,19401538,19132083,18801737,18480474,18369482,18264802,17158150,17137594,16403635,16075307,15875659,12796494">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">The NMR structure of the integrase-binding domain (IBD) in LEDGF/p75 reveals that residues Ile365, Asp366, or Phe406 in LEDGF/p75 mediate binding to HIV-1 integrase, and amino acids 165-173 of HIV-1 integrase are involved in the binding to LEDGF/p75</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25462529,22803661,21994603,21994569,21506277,20719241,20133638,19401538,19119323,18369482,18264802,17137594,16403635,16337983,16314581,16260736,15895093,15797927" href="/pubmed/25462529,22803661,21994603,21994569,21506277,20719241,20133638,19401538,19119323,18369482,18264802,17137594,16403635,16337983,16314581,16260736,15895093,15797927">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">A single mutation at residue Q168 of HIV-1 integrase disrupts its interaction with LEDGF/p75 and results in defective HIV-1 replication</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25462529,23863879,23369367,21510906,20719241,20367881,18369482,18264802,17158150,17137594,16987986,16959283,16439544,16314581,15855167" href="/pubmed/25462529,23863879,23369367,21510906,20719241,20367881,18369482,18264802,17158150,17137594,16987986,16959283,16439544,16314581,15855167">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 IN K264A/K266A mutant exhibits wild-type level of LEDGF/p75 binding, whereas A128T mutant displays slightly reduced binding to the cellular cofactor</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25118283" href="/pubmed/25118283">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Enhanced nuclear accumulation of HIV-1 IN in mouse MEF cells expressing human LEDGF/p75 suggests LEDGF/p75 stably transports the viral protein to chromatin</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24381568" href="/pubmed/24381568">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Molecular modeling study demonstrates that the LEDGF/p75 integrase binding domain residues Ile365, Asp366, Phe406 and Val408 have significant contributions to the binding of LEDGF/p75 to HIV1 IN</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 24599328" href="/pubmed/24599328">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Depletion of LEDGF/p75 leads to the accumulation of HIV-1 IN complex, which contains tetramers of IN exclusively in nuclear. IN Q168A mutant fails to accumulate in a nuclear low molecular weight complex</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23369367" href="/pubmed/23369367">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Mass spectrometry and Fluorescence Correlation Spectroscopy analyses show a stable complex between HIV-1 IN, viral U5 DNA, LEDGF/p75, and the integrase binding domain (amino acids 174-289) of INI1 with a 4/2/2/2 stoichiometry</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23593299" href="/pubmed/23593299">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Knockdown of HRP-2 by siRNA in LEDGF/p75-depleted cells reduces integration frequency in transcription units and shifts the integration distribution towards random</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23046603" href="/pubmed/23046603">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">HRP-2 functions as a co-factor of HIV-1 IN in LEDGF/p75-depleted cells. HRP-2 overexpression rescues HIV-1 replication and restored integration in genes to wild-type levels</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23046603" href="/pubmed/23046603">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">The NLS (amino acids 148-156) and AT-hook like domains (amino acids 178-197) constitute important contributions to enhance the binding of HIV-1 Integrase (IN) to DNA</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23043109,21763490" href="/pubmed/23043109,21763490">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Three peptides (354-378, 360-370, 400-413) derived from the IBD of LEDGF compete with LEDGF binding to HIV-1 IN. LEDGF-354-378 peptide shows the strongest binding competition</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22928108,22803661,21506277,20719241,19801648" href="/pubmed/22928108,22803661,21506277,20719241,19801648">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">In LEDGF/p75 knock-down cells, there is an increase in ubiquitinated HIV-1 integrase, which is found exclusively in the cytoplasm of these cells, and protection of HIV-1 integrase from the proteasome requires only interaction with LEDGF/p75</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 23863879,23024700,22928108,21994603,21409951,20719241,19389610,18369482,18264802,16439544,16403635,15475359" href="/pubmed/23863879,23024700,22928108,21994603,21409951,20719241,19389610,18369482,18264802,16439544,16403635,15475359">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Using a pull-down assay, LEDGF/p75 interacts with HIV-1, HIV-2, and FIV integrases and strongly promotes the binding of HIV-1 integrase to DNA in vitro</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22928108,21994603,19389610,18369482,18264802,17158150,16403635,15749713" href="/pubmed/22928108,21994603,19389610,18369482,18264802,17158150,16403635,15749713">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 integrase (IN) increases the binding strength of LEDGF/p75 deltaPWWP to chromatin, which requires the direct interaction of these two proteins. Integrase fails to increase chromatin binding of a LEDGF/p75 deltaPWWP/AT mutant</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22928108,21763490,21510906" href="/pubmed/22928108,21763490,21510906">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 IN mutant K264E supports the wild-type level of concerted integration activity and the efficient integration of endogenous viral DNA in vitro in the presence of LEDGF/p75</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22278243" href="/pubmed/22278243">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">The triple mutant RRK262/3/4/EEE in HIV-1 IN still maintains wild type levels of binding with LEDGF/p75</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22872640" href="/pubmed/22872640">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">LEDGF-derived peptides inhibit HIV-1 IN binding to DNA by shifting its oligomerization equilibrium toward the tetramer. The LEDGF peptides inhibit HIV-1 replication in cell culture by eliminating viral DNA integration</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22928108,21506277,21156026,20719241,18369482,18264802,17488811" href="/pubmed/22928108,21506277,21156026,20719241,18369482,18264802,17488811">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">The 146-156 amino acid stretch of LEDGF/p75 is critical for nuclear localization and a single amino acid mutation at K150A in LEDGF/p75 renders HIV-1 integrase cytoplasmic</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21506277,20719241,18369482,18264802,16403635,16314581,15163664" href="/pubmed/21506277,20719241,18369482,18264802,16403635,16314581,15163664">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Two LEDGF mutants (K401E/K402S/R405E and K401E/K402E/R405E) fail to interact with HIV-1 IN. The IN mutant (D6K/E10K/E13K) complements the interaction with the LEDGF mutant (K401E/K402E/R405E)</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21506277,19132083" href="/pubmed/21506277,19132083">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Replacing the N-terminal domain ensemble (NDE) of IN with strongly divergent chromatin-binding modules (i.e. H1 or KSHV LANA) can rescue integrase tethering and HIV-1 integration in LEDGF/p75-deficient cells</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 19609362" href="/pubmed/19609362">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">A serine cluster (residues 271, 273, and 275) in LEDGF/p75 is phosphorylated by protein kinase casein kinase 2 (PKCK2). S271/273/275A mutant impairs LEDGF/p75-mediate HIV-1 DNA integration without altering IN and chromatin binding</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21506277,19889764" href="/pubmed/21506277,19889764">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Alanine scan, fluorescence anisotropy studies, homology modeling and NMR demonstrate that all residues in LEDGF 361-370 contribute to IN binding and inhibition. Kinetic studies in cells show direct inhibition of viral cDNA integration by LEDGF 361-370</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22928108,21994569,21506277,20719241,20171172" href="/pubmed/22928108,21994569,21506277,20719241,20171172">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">A bi-helix motif (residues 149-186) in HIV-1 IN consists of the alpha(4) and alpha(5) helices connected by a 3 to 5-residue turn and binds to the LTR ends of virus DNA and to the IN binding domain (IBD) but not the IBD-Asp366Asn variant of LEDGF</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21506277,20331877,19119323" href="/pubmed/21506277,20331877,19119323">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 integrase (IN) and JPO2 bind mutually exclusively to LEDGF/p75. Two LEDGF/p75 mutants (I365A and D366N) abrogate interaction between LEDGF/p75 and IN but interact with JPO2 to the same extent as wild-type LEDGF/p75</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22334021,21506277,18369482,18264802,17669426" href="/pubmed/22334021,21506277,18369482,18264802,17669426">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 integration in cells depleted for LEDGF/p75 is less frequent in transcription units, less frequent in genes regulated by LEDGF/p75 and more frequent in GC-rich DNA</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22928108,22762018,18369482,18264802,18092005,17639082,17320002,16439544,16403635,16337983,16311605" href="/pubmed/22928108,22762018,18369482,18264802,18092005,17639082,17320002,16439544,16403635,16337983,16311605">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Results from molecular dynamics simulations show residues Gln168, Glu170 and Thr174 in chain A of HIV-1 Integrase (IN), Thr125 and Trp131 in chain B of IN as well as Ile365, Asp366, Phe406 and Val408 in LEDGF/p75 are responsible for IN-LEDGF/p75 binding</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21994569,21506277,18247352" href="/pubmed/21994569,21506277,18247352">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 IN mutants (V165A, A179P, and KR186,7AA) exhibit no chromatin-binding ability and fails to interact with LEDGF/p75</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21506277,19014595" href="/pubmed/21506277,19014595">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 Rev interacts with LEDGF/p75 to promote dissociation of HIV-1 IN-LEDGF/p75 complex</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20538907,19855849" href="/pubmed/20538907,19855849">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Mass spectrometry analysis shows a stable complex between human LEDGF/p75 and HIV-1 IN with a stoichiometry of 2 LEDGF/p75 and 4 IN</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22928108,22762018,21994569,21506277,19229293" href="/pubmed/22928108,22762018,21994569,21506277,19229293">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">The C-terminal domain of HIV-1 IN is masked in the presence of LEDGF/p75 protein in cell lysates, suggesting a structural rearrangement or oligomerization of IN</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 20367881" href="/pubmed/20367881">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 IN mutants (H171A, L172A, and EH170,1AA), located between the alpha4 and alpha5 helices of IN, severely impair the interaction with LEDGF/p75 but are still able to bind chromatin, suggesting IN-mediated LEDGF-independent chromatin targeting</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21506277,20331877" href="/pubmed/21506277,20331877">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Multiangle light scattering and small angle x-ray scattering analysis indicate full-length IN (wild-type and C56S/F139D/F185H/C280S mutant) and LEDGF/p75 (amino acids 325-530) form a tetramer complex with stoichiometry 4:4</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22928108,21994569,21506277,20406807" href="/pubmed/22928108,21994569,21506277,20406807">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Multiangle light scattering and small angle x-ray scattering analysis indicate full-length IN (C56S/F139D/F185H/C280S) and LEDGF/p75 (amino acids 347-471) form a tetramer, where each IN dimer binds only one LEDGF/p75</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22928108,21994569,21506277,20406807" href="/pubmed/22928108,21994569,21506277,20406807">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Analytical ultracentrifugation indicates IN (amino acids 1-212) and LEDGF/p75 (amino acids 347-471) form a complex with a molecular weight consistent with a 2:2 complex</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22928108,21506277,20406807" href="/pubmed/22928108,21506277,20406807">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Overexpression of the integrase binding domain (IBD) of LEDGF/p75 severely inhibits HIV-1 replication, while no inhibition is observed in cell lines overexpressing the interaction-deficient D366A mutant of integrase</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22928108,21270171,18369482,18264802,17488811,17397262,17320002,17158150,16987986" href="/pubmed/22928108,21270171,18369482,18264802,17488811,17397262,17320002,17158150,16987986">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">A single mutation at residue A128 or H171 of HIV-1 integrase diminishes its interaction with LEDGF/p75</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21506277,18369482,18264802,16959283" href="/pubmed/21506277,18369482,18264802,16959283">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">Intensified RNA interference and dominant-negative protein approaches show that LEDGF/p75 is an essential linkage between HIV-1 integrase and chromatin</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 21152581,18369482,18264802,17320002,16959972" href="/pubmed/21152581,18369482,18264802,17320002,16959972">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein"></td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">T-cell lines expressing a C-terminal fragment (residues 325-530) of LEDGF/p75 exhibit a reduced affinity of integrase for LEDGF/p75 and the blockage of viral replication. Both A128T and E170G IN mutations are together sufficient for viral rescue</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 22928108,22334021,21506277,18369482,18264802,17397262" href="/pubmed/22928108,22334021,21506277,18369482,18264802,17397262">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="hivprotein">
|
||
<a href="/protein/25121906">retropepsin</a>
|
||
</td>
|
||
<td headers="gene-hivprotein">
|
||
<a href="/gene/155348">gag-pol</a>
|
||
</td>
|
||
<td headers="hivinter">HIV-1 PR cleaves LEDGF/p75 at amino-acid positions 110-111, 159-160, 357-358, and 433-434 in HIV-1 particles</td>
|
||
<td headers="hivpub">
|
||
<a title="PubMed Id(s): 25809198" href="/pubmed/25809198">PubMed</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
<p class="withnote">
|
||
<a class="note" href="/genome/viruses/retroviruses/hiv-1/interactions/">Go to the HIV-1, Human Interaction Database </a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-pathways">
|
||
<section class="rprt-section-header" id="pathways">
|
||
<h2 id="header-pathways">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-pathways .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Pathways from PubChem</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<ul class="geneinfo-subsec infopathway">
|
||
<iframe title="Pathways in which the gene target is involved" class="pubchem-widget" scrolling="no" src="https://pubchem.ncbi.nlm.nih.gov/gene/11168#section=Pathways&embed=true&hide_all_headings=true&page_size=25" style="border: 0; width: 100%;"></iframe>
|
||
<script type="text/javascript" src="https://pubchem.ncbi.nlm.nih.gov/pcfe/libs/iframeResizer.min.js"></script>
|
||
<script type="text/javascript">iFrameResize({log: false, checkOrigin: false}, '.pubchem-widget')</script>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-interactions">
|
||
<section class="rprt-section-header" id="interactions">
|
||
<h2 id="header-interactions">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-interactions .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Interactions</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Interactions" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<table summary="Gene Interaction" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/11168/data/interaction/',webserviceParams: 'p$l=Ajax&p$debugoutput=off', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th id="inter-prod">Products</th>
|
||
<th id="inter-interactant">Interactant</th>
|
||
<th id="inter-otherGene">Other Gene</th>
|
||
<th id="inter-compl">Complex</th>
|
||
<th id="inter-source">Source</th>
|
||
<th id="inter-pubs">Pubs</th>
|
||
<th id="inter-desc">Description</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody></tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-general-gene-info">
|
||
<section class="rprt-section-header" id="general-gene-info">
|
||
<h2 id="header-general-gene-info">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-gene-info .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">General gene information</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.General_Gene_Information" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
|
||
<div class="rprt-section-body" style="">
|
||
<div id="gene-markers">
|
||
<h3 id="markers">
|
||
<a class="jig-ncbitoggler">Markers</a>
|
||
</h3>
|
||
<div>
|
||
<ul class="marker odd">
|
||
<li class="marker">RH16596 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=38460%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=11168&link_uid=38460">UniSTS:38460</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">D10S16 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=155756%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=11168&link_uid=155756">UniSTS:155756</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">D9S1149 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=83064%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=11168&link_uid=83064">UniSTS:83064</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">STS-R43279 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=27262%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=11168&link_uid=27262">UniSTS:27262</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">G27467 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=62598%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=11168&link_uid=62598">UniSTS:62598</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">G35007 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=55180%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=11168&link_uid=55180">UniSTS:55180</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">SHGC-64828 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=42662%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=11168&link_uid=42662">UniSTS:42662</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker ">
|
||
<li class="marker">RH102634 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=96968%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=11168&link_uid=96968">UniSTS:96968</a></li></ul></li>
|
||
</ul>
|
||
<ul class="marker odd">
|
||
<li class="marker">RH92265 (e-PCR)<ul class="marker-link"><li><a href="https://www.ncbi.nlm.nih.gov/probe?term=91365%20%5BUniSTS%20ID%5D" ref="ordinalpos=1&ncbi_uid=11168&link_uid=91365">UniSTS:91365</a></li></ul></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div>
|
||
<div class="infosec" id="Relatedpseudogenes"><h3 id="relatedpseudogenes"><a class="jig-ncbitoggler-open">Related pseudogene(s)</a></h3>
|
||
<dl class="geneinfo-subsec"><dt>3 found
|
||
|
||
<a href="/gene/?Term=related_functional_gene_11168%5Bgroup%5D">Review record(s) in Gene</a></dt></dl>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="infosec">
|
||
<h3 id="homology">
|
||
<a class="jig-ncbitoggler-open">Homology</a>
|
||
</h3>
|
||
<ul class="geneinfo-subsec">
|
||
<li>
|
||
<a href="/gene/11168/ortholog/" id="ncbi-ortholog-link">NCBI Orthologs</a>
|
||
</li>
|
||
<a href="https://www.orthodb.org/?ncbi=11168" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=8178" target="_blank">
|
||
Orthologs from OrthoDB
|
||
</a>
|
||
</ul>
|
||
</div>
|
||
|
||
<!--<component id="Gene_InfoPathway"/>-->
|
||
|
||
<div class="infosec info-comment" id="info-comment">
|
||
<h3 id="CloneNames">
|
||
<a class="jig-ncbitoggler-open">Clone Names</a>
|
||
</h3>
|
||
<ul class="geneinfo-subsec">
|
||
<li>MGC74712 </li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="gene-ontology infosec">
|
||
<h3 id="gene-ontology">
|
||
<a class="jig-ncbitoggler-open">
|
||
<span>Gene Ontology</span>
|
||
</a>
|
||
<a target="_blank" href="http://www.ebi.ac.uk/GOA" class="g-ontology-src" title="Provided by GOA">Provided by GOA</a>
|
||
</h3>
|
||
<div class="ontology-tables">
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Function</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0140297">enables DNA-binding transcription factor binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-1-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/9822615" target="_blank" title="PubMed ID 9822615" ref="ordinalpos=1&ncbi_uid=11168&link_uid=9822615">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0003723">enables RNA binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> HDA</a>
|
||
<div id="evidence-code-2-0" class="ecode">
|
||
<br />
|
||
<a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a>
|
||
</div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/22658674,22681889" target="_blank" title="PubMed ID 22658674,22681889" ref="ordinalpos=1&ncbi_uid=11168&link_uid=22658674,22681889">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0003682">enables chromatin binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-3-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/20974633" target="_blank" title="PubMed ID 20974633" ref="ordinalpos=1&ncbi_uid=11168&link_uid=20974633">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005515">enables protein binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IPI</a>
|
||
<div id="evidence-code-4-0" class="ecode">Inferred from Physical Interaction<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/9885563,17137594,21156026,22748127,22773103,22872640,25082813,25305204,29997176" target="_blank" title="PubMed ID 9885563,17137594,21156026,22748127,22773103,22872640,25082813,25305204,29997176" ref="ordinalpos=1&ncbi_uid=11168&link_uid=9885563,17137594,21156026,22748127,22773103,22872640,25082813,25305204,29997176">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0097100">enables supercoiled DNA binding</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
|
||
<div id="evidence-code-5-0" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-func">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0003713">enables transcription coactivator activity</a>
|
||
</td>
|
||
<td headers="ont-evi- ont-evi-code-">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-0', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-6-0" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi- ont-pub-"><a href="/pubmed/9822615,9885563" target="_blank" title="PubMed ID 9822615,9885563" ref="ordinalpos=1&ncbi_uid=11168&link_uid=9822615,9885563">PubMed</a> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-jigconfig="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Process</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0006338">involved_in chromatin remodeling</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-1-1" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0000395">involved_in mRNA 5'-splice site recognition</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-2-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9885563" target="_blank" title="PubMed ID 9885563" ref="ordinalpos=1&ncbi_uid=11168&link_uid=9885563">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0045944">involved_in positive regulation of transcription by RNA polymerase II</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-3-1" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"><a href="/pubmed/9822615,9885563" target="_blank" title="PubMed ID 9822615,9885563" ref="ordinalpos=1&ncbi_uid=11168&link_uid=9822615,9885563">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0009408">involved_in response to heat</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
|
||
<div id="evidence-code-4-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-comp">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0006979">involved_in response to oxidative stress</a>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-evi-code-2">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-1', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
|
||
<div id="evidence-code-5-1" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-2 ont-pub-2"> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
<div class="ui-ncbigrid-outer-div">
|
||
<div class="ui-ncbigrid-inner-div">
|
||
<table class="jig-ncbigrid" data-config="isPageable: true, pageSize : 25, isSortable: true, columnTypes: ['str', 'str', 'str']">
|
||
<thead>
|
||
<tr>
|
||
<th class="col1">Component</th>
|
||
<th style="width:12%;">Evidence Code</th>
|
||
<th style="width:10%;">Pubs</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005829">located_in cytosol</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-1-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-1-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0000791">located_in euchromatin</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-2-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> ISS</a>
|
||
<div id="evidence-code-2-2" class="ecode">Inferred from Sequence or Structural Similarity<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0000792">located_in heterochromatin</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-3-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-3-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/12796494" target="_blank" title="PubMed ID 12796494" ref="ordinalpos=1&ncbi_uid=11168&link_uid=12796494">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0034399">located_in nuclear periphery</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-4-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-4-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/11512661" target="_blank" title="PubMed ID 11512661" ref="ordinalpos=1&ncbi_uid=11168&link_uid=11512661">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005730">NOT located_in nucleolus</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-5-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-5-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/11512661" target="_blank" title="PubMed ID 11512661" ref="ordinalpos=1&ncbi_uid=11168&link_uid=11512661">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005654">located_in nucleoplasm</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-6-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-6-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/9885563" target="_blank" title="PubMed ID 9885563" ref="ordinalpos=1&ncbi_uid=11168&link_uid=9885563">PubMed</a> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005654">located_in nucleoplasm</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-7-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> TAS</a>
|
||
<div id="evidence-code-7-2" class="ecode">Traceable Author Statement<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005634">is_active_in nucleus</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-8-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IBA</a>
|
||
<div id="evidence-code-8-2" class="ecode">Inferred from Biological aspect of Ancestor<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"> </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="ont-proc">
|
||
<a href="http://amigo.geneontology.org/amigo/term/GO:0005634">located_in nucleus</a>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-evi-code-3">
|
||
<a class="jig-ncbipopper" href="http://geneontology.org/docs/guide-go-evidence-codes/" data-jigconfig="destSelector: '#evidence-code-9-2', hasArrow: true, openAnimation: 'none', closeAnimation: 'none', adjustFit: 'autoAdjust', triggerPosition: 'center right', destPosition: 'center left'"> IDA</a>
|
||
<div id="evidence-code-9-2" class="ecode">Inferred from Direct Assay<br /><a href="http://geneontology.org/docs/guide-go-evidence-codes/">more info</a></div>
|
||
</td>
|
||
<td headers="ont-evi-3 ont-pub-3"><a href="/pubmed/12796494" target="_blank" title="PubMed ID 12796494" ref="ordinalpos=1&ncbi_uid=11168&link_uid=12796494">PubMed</a> </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-general-protein-info">
|
||
<section class="rprt-section-header" id="general-protein-info">
|
||
<h2 id="header-general-protein-info">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-general-protein-info .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">General protein information</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.General_Protein_Information" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<dl>
|
||
<dt>Preferred Names</dt>
|
||
<dd>PC4 and SFRS1-interacting protein</dd>
|
||
</dl>
|
||
<dl>
|
||
<dt>Names</dt>
|
||
<dd>CLL-associated antigen KW-7</dd>
|
||
<dd>PC4 and SFRS1 interacting protein 1</dd>
|
||
<dd>dense fine speckles 70 kDa protein</dd>
|
||
<dd>lens epithelium-derived growth factor</dd>
|
||
<dd>transcriptional coactivator p52/p75</dd>
|
||
</dl>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="rprt-section gene-reference-sequences">
|
||
<section class="rprt-section-header" id="reference-sequences">
|
||
<h2 id="header-reference-sequences">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-reference-sequences .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">NCBI Reference Sequences (RefSeq)</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.NCBI_Reference_Sequences_RefS" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<p>
|
||
<span class="new-icon">NEW</span>
|
||
<strong>Try the new <a href="/datasets/tables/genes/?table_type=transcripts&ids=11168&utm_source=gene&utm_medium=referral&utm_campaign=refseq" title="View selected attributes for an input list of genes and download datasets containing genomic, transcript and protein sequences along with a detailed data report." data-ga-category="refseq" data-ga-action="click_datasets_link" data-ga-label="transcript_table">Transcript table</a></strong>
|
||
</p>
|
||
<h3 class="genomerefseqs gene_std_toggler" id="refseqset-independent">
|
||
<a class="jig-ncbitoggler-open">RefSeqs maintained independently of Annotated
|
||
Genomes</a>
|
||
</h3>
|
||
<div class="genomerefseqs_slave">
|
||
<p class="desc"> These reference sequences exist independently of genome builds. <a href="#refseq-expl" id="expl-refseg">Explain</a></p>
|
||
<p id="refseq-expl"> These reference sequences are curated independently of the genome
|
||
annotation cycle, so their versions may not match the RefSeq versions in the current
|
||
genome build. Identify version mismatches by comparing the version of the RefSeq in
|
||
this section to the one reported in <a href="#geneGenomic regions, transcripts, and products">Genomic regions,
|
||
transcripts, and products</a> above. </p>
|
||
<h4 id="mrnaandproteins-p50813440">mRNA and Protein(s) </h4>
|
||
<ol>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001128217.3">NM_001128217.3</a> → <a href="/protein/NP_001121689.1">NP_001121689.1</a> PC4 and SFRS1-interacting protein isoform 2</p>
|
||
<p>
|
||
<a href="/ipg/NP_001121689.1/" ref="ncbi_uid=11168">See identical proteins and their annotated locations for NP_001121689.1</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: VALIDATED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR, and 3' coding region, compared to variant 1. This results in a protein (isoform 2) with a longer, distinct C-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein (isoform 2).</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AF063020, AF432220, AL441925, BI547490">AF063020, AF432220, AL441925, BI547490</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS6479.1">CCDS6479.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/Swiss-Prot</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/D3DRI9" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">D3DRI9</a>, <a href="https://www.uniprot.org/uniprot/O00256" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">O00256</a>, <a href="https://www.uniprot.org/uniprot/O75475" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">O75475</a>, <a href="https://www.uniprot.org/uniprot/O95368" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">O95368</a>, <a href="https://www.uniprot.org/uniprot/Q6P391" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">Q6P391</a>, <a href="https://www.uniprot.org/uniprot/Q86YB9" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">Q86YB9</a>, <a href="https://www.uniprot.org/uniprot/Q9NZI3" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">Q9NZI3</a>, <a href="https://www.uniprot.org/uniprot/Q9UER6" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">Q9UER6</a></dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSP00000370114.4" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">ENSP00000370114.4</a>, <a href="http://www.ensembl.org/id/ENST00000380738.8" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">ENST00000380738.8</a></dd>
|
||
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001121689.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=99895">cd05834</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3</span> → <span class="cddto">87</span></dt>
|
||
<dd class="clearfix"> HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=173412">PTZ00121</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">89</span> → <span class="cddto">525</span></dt>
|
||
<dd class="clearfix"> PTZ00121; MAEBL; Provisional</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=402877">pfam11467</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">349</span> → <span class="cddto">442</span></dt>
|
||
<dd class="clearfix"> LEDGF; Lens epithelium-derived growth factor (LEDGF)</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001317898.3">NM_001317898.3</a> → <a href="/protein/NP_001304827.1">NP_001304827.1</a> PC4 and SFRS1-interacting protein isoform 3</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: VALIDATED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the 3' terminal exon, compared to variant 1. This variant encodes isoform 3, which is shorter and has a distinct C-terminus compared to isoform 1.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AL513423, BC044568">AL513423, BC044568</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS83348.1">CCDS83348.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/Swiss-Prot</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/O75475" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">O75475</a>
|
||
</dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSP00000370091.1" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">ENSP00000370091.1</a>, <a href="http://www.ensembl.org/id/ENST00000380715.5" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">ENST00000380715.5</a></dd>
|
||
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001304827.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=99895">cd05834</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3</span> → <span class="cddto">87</span></dt>
|
||
<dd class="clearfix"> HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=173412">PTZ00121</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">89</span> → <span class="cddto">325</span></dt>
|
||
<dd class="clearfix"> PTZ00121; MAEBL; Provisional</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_001317900.3">NM_001317900.3</a> → <a href="/protein/NP_001304829.1">NP_001304829.1</a> PC4 and SFRS1-interacting protein isoform 4</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: VALIDATED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. This variant encodes isoform 4, which is shorter than isoform 1.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AL513423, BC064135, BI547490">AL513423, BC064135, BI547490</a>
|
||
</dd>
|
||
<dt>UniProtKB/Swiss-Prot</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/O75475" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">O75475</a>
|
||
</dd>
|
||
<dt class="clear"> Conserved Domains (1) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_001304829.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=99895">cd05834</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3</span> → <span class="cddto">87</span></dt>
|
||
<dd class="clearfix"> HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_021144.4">NM_021144.4</a> → <a href="/protein/NP_066967.3">NP_066967.3</a> PC4 and SFRS1-interacting protein isoform 1</p>
|
||
<p>
|
||
<a href="/ipg/NP_066967.3/" ref="ncbi_uid=11168">See identical proteins and their annotated locations for NP_066967.3</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: VALIDATED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (1) represents the shortest transcript and encodes isoform 1.</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AF098482, AL513423, BC064135, BQ186453, BX649155">AF098482, AL513423, BC064135, BQ186453, BX649155</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS6480.1">CCDS6480.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/Swiss-Prot</dt>
|
||
<dd>
|
||
<a href="https://www.uniprot.org/uniprot/O75475" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">O75475</a>
|
||
</dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSP00000380653.2" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">ENSP00000380653.2</a>, <a href="http://www.ensembl.org/id/ENST00000397519.6" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">ENST00000397519.6</a></dd>
|
||
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_066967.3">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=99895">cd05834</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3</span> → <span class="cddto">87</span></dt>
|
||
<dd class="clearfix"> HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=173412">PTZ00121</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">89</span> → <span class="cddto">325</span></dt>
|
||
<dd class="clearfix"> PTZ00121; MAEBL; Provisional</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/NM_033222.5">NM_033222.5</a> → <a href="/protein/NP_150091.2">NP_150091.2</a> PC4 and SFRS1-interacting protein isoform 2</p>
|
||
<p>
|
||
<a href="/ipg/NP_150091.2/" ref="ncbi_uid=11168">See identical proteins and their annotated locations for NP_150091.2</a>
|
||
</p>
|
||
<p style="background:#fff; margin-top:1em;">Status: VALIDATED</p>
|
||
<dl>
|
||
<dt>Description</dt>
|
||
<dd>Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and 3' coding region, compared to variant 1. This results in a protein (isoform 2) with a longer, distinct C-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein (isoform 2).</dd>
|
||
<dt>Source sequence(s)</dt>
|
||
<dd class="wordwrap">
|
||
<a href="/nuccore/AF063020, AL441925">AF063020, AL441925</a>
|
||
</dd>
|
||
<dt>Consensus CDS</dt>
|
||
<dd>
|
||
<a href="/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS6479.1">CCDS6479.1</a>
|
||
</dd>
|
||
<dt>UniProtKB/Swiss-Prot</dt>
|
||
<dd><a href="https://www.uniprot.org/uniprot/D3DRI9" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">D3DRI9</a>, <a href="https://www.uniprot.org/uniprot/O00256" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">O00256</a>, <a href="https://www.uniprot.org/uniprot/O75475" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">O75475</a>, <a href="https://www.uniprot.org/uniprot/O95368" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">O95368</a>, <a href="https://www.uniprot.org/uniprot/Q6P391" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">Q6P391</a>, <a href="https://www.uniprot.org/uniprot/Q86YB9" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">Q86YB9</a>, <a href="https://www.uniprot.org/uniprot/Q9NZI3" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">Q9NZI3</a>, <a href="https://www.uniprot.org/uniprot/Q9UER6" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">Q9UER6</a></dd>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSP00000370109.4" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">ENSP00000370109.4</a>, <a href="http://www.ensembl.org/id/ENST00000380733.9" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">ENST00000380733.9</a></dd>
|
||
<dt class="clear"> Conserved Domains (3) <a href="/Structure/cdd/wrpsb.cgi?seqinput=NP_150091.2">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=99895">cd05834</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3</span> → <span class="cddto">87</span></dt>
|
||
<dd class="clearfix"> HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=173412">PTZ00121</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">89</span> → <span class="cddto">525</span></dt>
|
||
<dd class="clearfix"> PTZ00121; MAEBL; Provisional</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=402877">pfam11467</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">349</span> → <span class="cddto">442</span></dt>
|
||
<dd class="clearfix"> LEDGF; Lens epithelium-derived growth factor (LEDGF)</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
<h3 class="genomerefseqs gene_std_toggler" id="annotatedrefseq-title">
|
||
<a class="jig-ncbitoggler-open">RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08</a>
|
||
</h3>
|
||
<div class="genomerefseqs_slave">
|
||
<p class="desc"> The following sections contain reference sequences that belong to a
|
||
specific genome build. <a href="#" id="expl-genomes">Explain</a></p>
|
||
<p id="expl-genomes-desc" style="display:none">This section includes genomic Reference
|
||
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
|
||
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
|
||
assemblies. Model RNAs and proteins are also reported here.</p>
|
||
<h3 id="refseq-sequencedescription-p252330656">Reference GRCh38.p14 Primary Assembly</h3>
|
||
<h4 id="genomic-p252330656">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NC_000009.12 Reference GRCh38.p14 Primary Assembly</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>15464066..15510970 complement</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NC_000009.12?from=15464066&to=15510970&report=genbank&strand=true" ref="ordinalpos=1&ncbi_uid=11168&link_uid=NC_000009.12?from=15464066&to=15510970&report=genbank&strand=true">GenBank</a>, <a href="/nuccore/NC_000009.12?from=15464066&to=15510970&report=fasta&strand=true" ref="ordinalpos=1&ncbi_uid=11168&link_uid=NC_000009.12?from=15464066&to=15510970&report=fasta&strand=true">FASTA</a>, <a href="/nuccore/NC_000009.12?from=15457029&to=15518005&report=graph&content=5&strand=true" ref="ordinalpos=1&ncbi_uid=11168&link_uid=NC_000009.12?from=15457029&to=15518005&report=graph&content=5&strand=true">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
<h4 id="mrnaandproteins-p39818240">mRNA and Protein(s) </h4>
|
||
<ol>
|
||
<li>
|
||
<p><a href="/nuccore/XM_047422702.1">XM_047422702.1</a> → <a href="/protein/XP_047278658.1">XP_047278658.1</a> PC4 and SFRS1-interacting protein isoform X1</p>
|
||
<dl></dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/XM_047422703.1">XM_047422703.1</a> → <a href="/protein/XP_047278659.1">XP_047278659.1</a> PC4 and SFRS1-interacting protein isoform X2</p>
|
||
<dl>
|
||
<dt>Related</dt>
|
||
<dd><a href="http://www.ensembl.org/id/ENSP00000370092.4" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">ENSP00000370092.4</a>, <a href="http://www.ensembl.org/id/ENST00000380716.8" ref="itool=Gene_FullReport&PrId=5380&uid=11168&nlmid=&db=gene">ENST00000380716.8</a></dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/XM_024447399.2">XM_024447399.2</a> → <a href="/protein/XP_024303167.1">XP_024303167.1</a> PC4 and SFRS1-interacting protein isoform X1</p>
|
||
<dl>
|
||
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_024303167.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=99895">cd05834</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3</span> → <span class="cddto">87</span></dt>
|
||
<dd class="clearfix"> HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=331332">cl26511</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">89</span> → <span class="cddto">344</span></dt>
|
||
<dd class="clearfix"> Neuromodulin_N; Gap junction protein N-terminal region</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/XM_024447400.2">XM_024447400.2</a> → <a href="/protein/XP_024303168.1">XP_024303168.1</a> PC4 and SFRS1-interacting protein isoform X2</p>
|
||
<dl>
|
||
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_024303168.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=99895">cd05834</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3</span> → <span class="cddto">87</span></dt>
|
||
<dd class="clearfix"> HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=173412">PTZ00121</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">89</span> → <span class="cddto">325</span></dt>
|
||
<dd class="clearfix"> PTZ00121; MAEBL; Provisional</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/XM_024447402.2">XM_024447402.2</a> → <a href="/protein/XP_024303170.1">XP_024303170.1</a> PC4 and SFRS1-interacting protein isoform X4</p>
|
||
<dl>
|
||
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_024303170.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=99895">cd05834</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3</span> → <span class="cddto">87</span></dt>
|
||
<dd class="clearfix"> HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=173412">PTZ00121</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">89</span> → <span class="cddto">325</span></dt>
|
||
<dd class="clearfix"> PTZ00121; MAEBL; Provisional</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/XM_047422704.1">XM_047422704.1</a> → <a href="/protein/XP_047278660.1">XP_047278660.1</a> PC4 and SFRS1-interacting protein isoform X3</p>
|
||
<dl></dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/XM_024447401.2">XM_024447401.2</a> → <a href="/protein/XP_024303169.1">XP_024303169.1</a> PC4 and SFRS1-interacting protein isoform X3</p>
|
||
<dl>
|
||
<dt class="clear"> Conserved Domains (2) <a href="/Structure/cdd/wrpsb.cgi?seqinput=XP_024303169.1">summary</a></dt>
|
||
<dd>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=99895">cd05834</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">3</span> → <span class="cddto">87</span></dt>
|
||
<dd class="clearfix"> HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...</dd>
|
||
</dl>
|
||
<dl class="level2">
|
||
<dt><a href="/Structure/cdd/cddsrv.cgi?uid=173412">PTZ00121</a><br /><span class="cddlocation">Location:</span><span class="cddfrom">89</span> → <span class="cddto">330</span></dt>
|
||
<dd class="clearfix"> PTZ00121; MAEBL; Provisional</dd>
|
||
</dl>
|
||
</dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
<h3 id="refseq-sequencedescription-p119881488">Alternate T2T-CHM13v2.0</h3>
|
||
<h4 id="genomic-p119881488">Genomic </h4>
|
||
<ol>
|
||
<li>
|
||
<p>NC_060933.1 Alternate T2T-CHM13v2.0</p>
|
||
<dl>
|
||
<dt>Range</dt>
|
||
<dd class="rs-range">
|
||
<span>15475998..15522882 complement</span>
|
||
</dd>
|
||
<dt>Download</dt>
|
||
<dd><a href="/nuccore/NC_060933.1?from=15475998&to=15522882&report=genbank&strand=true" ref="ordinalpos=1&ncbi_uid=11168&link_uid=NC_060933.1?from=15475998&to=15522882&report=genbank&strand=true">GenBank</a>, <a href="/nuccore/NC_060933.1?from=15475998&to=15522882&report=fasta&strand=true" ref="ordinalpos=1&ncbi_uid=11168&link_uid=NC_060933.1?from=15475998&to=15522882&report=fasta&strand=true">FASTA</a>, <a href="/nuccore/NC_060933.1?from=15468964&to=15529914&report=graph&content=5&strand=true" ref="ordinalpos=1&ncbi_uid=11168&link_uid=NC_060933.1?from=15468964&to=15529914&report=graph&content=5&strand=true">Sequence Viewer (Graphics)</a></dd>
|
||
</dl>
|
||
</li>
|
||
</ol>
|
||
<h4 id="mrnaandproteins-p43963840">mRNA and Protein(s) </h4>
|
||
<ol>
|
||
<li>
|
||
<p><a href="/nuccore/XM_054361870.1">XM_054361870.1</a> → <a href="/protein/XP_054217845.1">XP_054217845.1</a> PC4 and SFRS1-interacting protein isoform X1</p>
|
||
<dl></dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/XM_054361874.1">XM_054361874.1</a> → <a href="/protein/XP_054217849.1">XP_054217849.1</a> PC4 and SFRS1-interacting protein isoform X3</p>
|
||
<dl></dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/XM_054361871.1">XM_054361871.1</a> → <a href="/protein/XP_054217846.1">XP_054217846.1</a> PC4 and SFRS1-interacting protein isoform X1</p>
|
||
<dl></dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/XM_054361875.1">XM_054361875.1</a> → <a href="/protein/XP_054217850.1">XP_054217850.1</a> PC4 and SFRS1-interacting protein isoform X3</p>
|
||
<dl></dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/XM_054361872.1">XM_054361872.1</a> → <a href="/protein/XP_054217847.1">XP_054217847.1</a> PC4 and SFRS1-interacting protein isoform X2</p>
|
||
<dl></dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/XM_054361873.1">XM_054361873.1</a> → <a href="/protein/XP_054217848.1">XP_054217848.1</a> PC4 and SFRS1-interacting protein isoform X2</p>
|
||
<dl></dl>
|
||
</li>
|
||
<li>
|
||
<p><a href="/nuccore/XM_054361876.1">XM_054361876.1</a> → <a href="/protein/XP_054217851.1">XP_054217851.1</a> PC4 and SFRS1-interacting protein isoform X4</p>
|
||
<dl></dl>
|
||
</li>
|
||
</ol>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-related-sequences">
|
||
<section class="rprt-section-header" id="related-sequences">
|
||
<h2 id="header-related-sequences">
|
||
<a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-related-sequences .rprt-section-body'">
|
||
<span class="ui-ncbitoggler-master-text">Related sequences</span>
|
||
</a>
|
||
</h2>
|
||
<div class="rprt-section-tools">
|
||
<a href="#top" title="Go to the top of the page" class="gene-top-page">
|
||
<span>Go to the top of the page</span>
|
||
</a>
|
||
<a href="/books/NBK3841/#EntrezGene.Related_Sequences" title="Help" class="gene-section-help">
|
||
<span>Help</span>
|
||
</a>
|
||
</div>
|
||
</section>
|
||
<div class="rprt-section-body">
|
||
<div>
|
||
<table id="proteinTblId" class="jig-ncbiservergrid" data-jigconfig="webservice:'/gene/11168/data/related-sequences/',webserviceParams: 'p$l=Ajax', isServersideLoad:true, isServersidePaging: true,isServersidePagingCached: true,pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th colspan="2" id="rs-nucleo">Nucleotide</th>
|
||
<th rowspan="2" id="rs-protein">Protein</th>
|
||
</tr>
|
||
<tr>
|
||
<th id="rs-heading">Heading</th>
|
||
<th id="rs-heading-acc">Accession and Version</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody></tbody>
|
||
</table>
|
||
<table id="proteinTblId" class="jig-ncbigrid" data-jigconfig="isPageable:true, pageSize:25">
|
||
<thead>
|
||
<tr>
|
||
<th class="proteinTblTh" rowspan="2" id="rs-prot-acc">Protein Accession</th>
|
||
<th class="proteinTblTh" colspan="2" id="rs-link">Links</th>
|
||
</tr>
|
||
<tr>
|
||
<th id="rs-genepept">GenPept Link</th>
|
||
<th id="rs-uniprot">UniProtKB Link</th>
|
||
</tr>
|
||
</thead>
|
||
<tbody>
|
||
<tr>
|
||
<td headers="rs-prot-acc">O75475.1</td>
|
||
<td headers="rs-link rs-genepept">
|
||
<a href="/protein/68565853" ref="ordinalpos=1&ncbi_uid=11168&link_uid=68565853">GenPept</a>
|
||
</td>
|
||
<td>
|
||
<a href="https://www.uniprot.org/uniprot/O75475">UniProtKB/Swiss-Prot:O75475</a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="rprt-section gene-additional-links">
|
||
|
||
<section class="rprt-section-header" id="additional-links"><h2 id="header-additional-links"><a href="#" class="jig-ncbitoggler-open" data-jigconfig="targets: '.gene-additional-links .rprt-section-body'"><span class="ui-ncbitoggler-master-text">Additional links</span></a></h2><div class="rprt-section-tools"><a href="#top" title="Go to the top of the page" class="gene-top-page"><span>Go to the top of the page</span></a><a href="/books/NBK3841/#EntrezGene.Additional_Links" title="Help" class="gene-section-help"><span>Help</span></a></div></section>
|
||
|
||
<div class="rprt-section-body" style="">
|
||
|
||
|
||
<h3 class="withnote" id="genelinkout">
|
||
<a class="jig-ncbitoggler">Gene LinkOut</a>
|
||
</h3><div>
|
||
<p>The following <a href="https://www.ncbi.nlm.nih.gov/projects/linkout/index.html">LinkOut</a> resources are supplied by external providers. These providers are responsible for maintaining the links. </p>
|
||
<div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Chemical Information</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Interologous Interaction Database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://ophid.utoronto.ca/redirect/ncbi/human?proteins=11168" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=7911">
|
||
<span>Interologous Interaction Database</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>MilliporeSigma</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.sigmaaldrich.com/catalog/genes/PSIP1?lang=en&region=US" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=9978">
|
||
<span>Psip1 products</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Molecular Biology Databases</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Bgee database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.bgee.org/gene/ENSG00000164985" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=10418">
|
||
<span>PSIP1 gene expression</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>BioGPS</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://biogps.org/gene/11168/" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=5059">
|
||
<span>BioGPS</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>BioGRID Open Repository of CRISPR Screens (ORCS)</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://orcs.thebiogrid.org/Gene/11168" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=10164">
|
||
<span>BioGRID CRISPR Screen Phenotypes (50 hits/1378 screens)</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>CTD: Comparative Toxicogenomics Database</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://ctdbase.org/detail.go?type=gene&acc=11168" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=7845">
|
||
<span>CTD: Comparative Toxicogenomics Database - PSIP1</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Domain Mapping of Disease Mutations</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://bioinf.umbc.edu/DMDM/gene_prot_page.php?id=11168" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=7642">
|
||
<span>PSIP1</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>GlyGen glycoinformatics resource</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://glygen.org/protein/O75475" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=10227">
|
||
<span>GlyGen glycoinformatics resource</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Human eFP Browser</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Skeletal_Immune_Digestive&modeInput=Absolute&primaryGene=11168" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=8875">
|
||
<span>Human eFP Browser</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Nervous&modeInput=Absolute&primaryGene=11168" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=8875">
|
||
<span>Human eFP Browser</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="http://bar.utoronto.ca/efp_human/cgi-bin/efpWeb.cgi?dataSource=Circulatory_Respiratory&modeInput=Absolute&primaryGene=11168" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=8875">
|
||
<span>Human eFP Browser</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li>Ingenuity Pathways Analysis</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://partnersolution.ingenuity.com/?cid=97ae3f91eab87a&p1=Entrez&p2=GV&s=&ipaUri=%2Fpa%2Fapi%2Fv2%2Fgeneview%3Fapplicationname%3DEntrez%26geneId%3D11168%26geneidtype%3Dentrezgene" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=5628">
|
||
<span>Ingenuity Pathways Analysis</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>InnateDB</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.innatedb.com/getGeneCard.do?id=51337" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=7894">
|
||
<span>InnateDB</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>InterMine</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.humanmine.org/humanmine/search?keyword=ENSG00000164985" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=9169">
|
||
<span>InterMine</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>Kyoto Encyclopedia of Genes and Genomes</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.genome.jp/dbget-bin/www_bget?hsa:11168" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=5174">
|
||
<span>Kyoto Encyclopedia of Genes and Genomes</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>OMA Browser: Orthologous MAtrix</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN96494/" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=9822">
|
||
<span>OMA Browser: Orthologous MAtrix</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN96498/" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=9822">
|
||
<span>OMA Browser: Orthologous MAtrix</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://omabrowser.org/oma/info/HUMAN96495/" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=9822">
|
||
<span>OMA Browser: Orthologous MAtrix</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>OrthoDB catalog of orthologs</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.orthodb.org/?ncbi=11168" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=8178">
|
||
<span>Orthologs</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>PhosphoSitePlus</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.phosphosite.org/entrezGeneIdAction.action?id=11168" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=7987">
|
||
<span>PhosphoSitePlus® - comprehensive post-translational modification resource</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>The Gene Wiki</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://en.wikipedia.org/wiki/PSIP1" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=6933">
|
||
<span>The Gene Wiki</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="free-rsc"></span>The Weizmann Institute of Science GeneCards and MalaCards databases</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=PSIP1" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=8598">
|
||
<span>GeneCard for PSIP1</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Research Materials</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="order-rsc"></span>Addgene Non-profit plasmid repository</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://addgene.org//browse/gene/11168" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=5304">
|
||
<span>Get Plasmids - Addgene</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>Bio-Techne</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.bio-techne.com/t/ledgf/antibodies?utm_source=linkout&utm_medium=referral&utm_campaign=product&utm_term=antibodies" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=8242">
|
||
<span>LEDGF Antibodies</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.bio-techne.com/t/ledgf/proteins-enzymes?utm_source=linkout&utm_medium=referral&utm_campaign=product&utm_term=proteins" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=8242">
|
||
<span>LEDGF Proteins</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li>ExactAntigen/Labome</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.labome.com/gene/human/PSIP1-antibody.html" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=5753">
|
||
<span>reagents</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.labome.com/review/gene/human/PSIP1-antibody.html" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=5753">
|
||
<span>reagent review</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GenScript latest version of gene cDNA ORF Clone</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://www.genscript.com/gene/11168" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=8012">
|
||
<span>GenScript latest version of gene cDNA ORF Clone</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>GeneCopoeia Inc.</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=22&field=5&key=11168" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order promoter clone</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=11&field=5&key=11168" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order shRNA clones</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://www.genecopoeia.com/product/search/result.php?prt=1&field=5&key=11168" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=7255">
|
||
<span>Order full-length ORF clone</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
<li><span class="order-rsc"></span>OriGene</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://www.origene.com/search?q=PSIP1" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=7994">
|
||
<span>Order PSIP1 cDNA clone/Protein/Antibody/RNAi</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open main">
|
||
<span>Tools</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>GeneMANIA</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="http://genemania.org/link?o=9606&g=11168" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=7529">
|
||
<span>GeneMANIA</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
<div class="linkout">
|
||
<a class="jig-ncbitoggler-open">
|
||
<span>Miscellaneous</span>
|
||
</a>
|
||
<ul>
|
||
<li><span class="free-rsc"></span>Reactome</li>
|
||
<ul>
|
||
<li>
|
||
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-1643685" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=4914">
|
||
<span>Reactome Event:Disease</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://reactome.org/PathwayBrowser/#/R-HSA-74160" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=4914">
|
||
<span>Reactome Event:Gene expression (Transcription)</span>
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a target="_blank" href="https://reactome.org/content/query?q=UniProt:O75475" ref="itool=Gene_FullReport&uid=11168&nlmid=&db=gene&log$=linkoutlink&PrId=4914">
|
||
<span>Reactome Entity:O75475</span>
|
||
</a>
|
||
</li>
|
||
</ul>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="urls-in-genombrowser" style="display:none">
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div><input type="hidden" class="section_status_input" name="status_checked" id="status_checked" value="" /><input type="hidden" class="section_status_input" name="status_open" id="status_open" value="summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links" /><input type="hidden" class="section_status_input" name="status_exist" id="status_exist" value="summary,context,region,expression,bibliography,phenotypes,variation,hiv,,interactions,geneInfo,proteinInfo,refSeq,related,links" /><input type="hidden" class="section_status_input" name="status_closed" id="status_closed" value="" /><meta name="status_checked" content="" class="meta_section_status" /><meta name="status_open" content="summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links" class="meta_section_status" /><meta name="status_exist" content="summary,context,region,expression,bibliography,phenotypes,variation,hiv,,interactions,geneInfo,proteinInfo,refSeq,related,links" class="meta_section_status" /><meta name="status_closed" content="" class="meta_section_status" /><script type="text/javascript">
|
||
|
||
var section_status_meta = {
|
||
'status_checked': '',
|
||
'status_open': 'summary,region,context,bibliography,phenotypes,variation,hiv,interactions,pathways,geneInfo,proteinInfo,refSeq,related,links',
|
||
'status_exist': 'summary,context,region,expression,bibliography,phenotypes,variation,hiv,,interactions,geneInfo,proteinInfo,refSeq,related,links',
|
||
'status_closed': ''
|
||
};
|
||
|
||
|
||
/*
|
||
for (var o in section_status_meta) {
|
||
var meta=document.createElement('meta');
|
||
meta.name = o;
|
||
meta.content = section_status_meta[o];
|
||
var attr = document.createAttribute('data-ignore-limit');
|
||
attr.value = 'true';
|
||
meta.setAttributeNode(attr);
|
||
document.getElementsByTagName('head')[0].appendChild(meta);
|
||
}
|
||
*/
|
||
|
||
|
||
var __ncbi_sg_pingCallbacks_render_gene = function (data, evtObj, type) {
|
||
// data looks like {jsevent: "click", "link_id": "foo", ...}
|
||
// evtObj is the JS event object
|
||
// type is either "stat" (for applog) or "ga"
|
||
var extraData = {};
|
||
if (type == "stat") {
|
||
for (var o in section_status_meta) {
|
||
extraData[o] = section_status_meta[o];
|
||
}
|
||
|
||
return extraData;
|
||
|
||
}
|
||
}
|
||
|
||
|
||
</script></div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last" id="sidebar_tabular">
|
||
<!-- sidebar close/hide button-->
|
||
<div class="ui-helper-clearfix">
|
||
<a href="#" id="sidecontent_2_pullout" style="float:right;" class="sidecontentpullout_local collapse_button"><span>Hide sidebar >></span></a>
|
||
</div>
|
||
<!-- end sidebar close/hide button-->
|
||
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div id="gene-sidebar">
|
||
<div>
|
||
<div class="portlet brieflink dis-table-of-contents">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Table of contents</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_TableOfContents" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_TableOfContents.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li class="">
|
||
<a href="#summary">Summary</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#genomic-context">Genomic context</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#genomic-regions-transcripts-products">Genomic regions, transcripts, and products</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#gene-expression">Expression</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#bibliography">Bibliography</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#phenotypes">Phenotypes</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#variation">Variation</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#HIV-1-interactions">HIV-1 interactions</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#pathways">Pathways from PubChem</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#interactions">Interactions</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#general-gene-info">General gene information</a>
|
||
<div class="subsection-links"><a href="#gene-markers">Markers</a>, <a href="#Relatedpseudogenes">Related pseudogene(s)</a>, <a href="#CloneNames">Clone Names</a>, <a href="#homology">Homology</a>, <a href="#gene-ontology">Gene Ontology</a></div>
|
||
</li>
|
||
<li class="">
|
||
<a href="#general-protein-info">General protein information</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#reference-sequences">NCBI Reference Sequences (RefSeq)</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#related-sequences">Related sequences</a>
|
||
</li>
|
||
<li class="">
|
||
<a href="#additional-links">Additional links</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-genomesbrowser brieflink dis-genomesbrowser">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Genome Browsers</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GenomeBrowsers" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GenomeBrowsers.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="#">Loading...</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet dis-related-info brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedInformation.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clone/order/gene/11168" ref="log$=recordlinks">Order cDNA clone</a>
|
||
<div class="brieflinkpop offscreen_noflow">Order cDNA clone</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/structure?LinkName=gene_structure&from_uid=11168" ref="log$=recordlinks">3D structures</a>
|
||
<div class="brieflinkpop offscreen_noflow">3D structure of a gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_alltarget_list&from_uid=11168" ref="log$=recordlinks">BioAssay by Target (List)</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays related to the gene by protein target or RNAi target</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="//pubchem.ncbi.nlm.nih.gov/assay/bioactivity.html?geneid=11168" ref="log$=recordlinks">BioAssay by Target (Summary)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Summarized PubChem Data on the gene, showing the active data by default</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_target&from_uid=11168" ref="log$=recordlinks">BioAssay, by Gene target</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem BioAssays done on the Gene target</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai_active&from_uid=11168" ref="log$=recordlinks">BioAssays, RNAi Target, Active</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent, which is identified as a hit in a RNAi screening and flagged as "active" in the corresponding BioAssay record</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcassay?LinkName=gene_pcassay_rnai&from_uid=11168" ref="log$=recordlinks">BioAssays, RNAi Target, Tested</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioAssays that contain the gene as the target of a RNAi reagent</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/bioproject?LinkName=gene_bioproject&from_uid=11168" ref="log$=recordlinks">BioProjects</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioProjects related to a gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/biosystems?LinkName=gene_biosystems&from_uid=11168" ref="log$=recordlinks">BioSystems</a>
|
||
<div class="brieflinkpop offscreen_noflow">BioSystems</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/CCDS/CcdsBrowse.cgi?REQUEST=GENEID&DATA=11168" ref="log$=recordlinks">CCDS</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to CCDS</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar&from_uid=11168" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/cdd?LinkName=gene_cdd&from_uid=11168" ref="log$=recordlinks">Conserved Domains</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related CDD</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/dbvar?LinkName=gene_dbvar&from_uid=11168" ref="log$=recordlinks">dbVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link from Gene to dbVar</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc&from_uid=11168" ref="log$=recordlinks">Full text in PMC</a>
|
||
<div class="brieflinkpop offscreen_noflow">PMC links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=gene_pmc_nucleotide&from_uid=11168" ref="log$=recordlinks">Full text in PMC_nucleotide</a>
|
||
<div class="brieflinkpop offscreen_noflow">Full text in PubMedCentral identified from shared sequence links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/sparcle?LinkName=gene_sparcle&from_uid=11168" ref="log$=recordlinks">Functional Class</a>
|
||
<div class="brieflinkpop offscreen_noflow">Functional class of the sequence domain architecture</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_neighbors&from_uid=11168" ref="log$=recordlinks">Gene neighbors</a>
|
||
<div class="brieflinkpop offscreen_noflow">Overlapping genes and two nearest non-overlapping genes on either side</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=gene_gene_h3k4me3&from_uid=11168" ref="log$=recordlinks">Genes with a similar H3K4me3 profile</a>
|
||
<div class="brieflinkpop offscreen_noflow">Genes with a similar profile of promoter-activating H3K4me3 modifications across several tissue types</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/genome?LinkName=gene_genome&from_uid=11168" ref="log$=recordlinks">Genome</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Genome</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/geoprofiles?LinkName=gene_geoprofiles&from_uid=11168" ref="log$=recordlinks">GEO Profiles</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related GEO</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests/?term=11168[geneid]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Tests for this gene in the NIH Genetic Testing Registry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/homologene?LinkName=gene_homologene&from_uid=11168" ref="log$=recordlinks">HomoloGene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related HomoloGene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore&from_uid=11168" ref="log$=recordlinks">Nucleotide</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related Nucleotide entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=gene_omim&from_uid=11168" ref="log$=recordlinks">OMIM</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related OMIM entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/probe?LinkName=gene_probe&from_uid=11168" ref="log$=recordlinks">Probe</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Probe entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein&from_uid=11168" ref="log$=recordlinks">Protein</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related protein entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pccompound?LinkName=gene_pccompound&from_uid=11168" ref="log$=recordlinks">PubChem Compound</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem Compounds</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pcsubstance?LinkName=gene_pcsubstance&from_uid=11168" ref="log$=recordlinks">PubChem Substance</a>
|
||
<div class="brieflinkpop offscreen_noflow">PubChem Substances</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed&from_uid=11168" ref="log$=recordlinks">PubMed</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related PubMed entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_rif&from_uid=11168" ref="log$=recordlinks">PubMed (GeneRIF)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related PubMed article from GeneRIFs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_citedinomim&from_uid=11168" ref="log$=recordlinks">PubMed (OMIM)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Gene links to PubMed derived from omim_pubmed_cited links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=gene_pubmed_pmc_nucleotide&from_uid=11168" ref="log$=recordlinks">PubMed(nucleotide/PMC)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Citations in PubMed identified from shared sequence and PMC links.</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/protein?LinkName=gene_protein_refseq&from_uid=11168" ref="log$=recordlinks">RefSeq Proteins</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to Protein RefSeqs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/nuccore?LinkName=gene_nuccore_refseqrna&from_uid=11168" ref="log$=recordlinks">RefSeq RNAs</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to Nucleotide RefSeq RNAs</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=gene_clinvar_specific&from_uid=11168" ref="log$=recordlinks">Related gene-specific medical variations</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/snp?LinkName=gene_snp&from_uid=11168" ref="log$=recordlinks">SNP</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related SNP records</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/taxonomy?LinkName=gene_taxonomy&from_uid=11168" ref="log$=recordlinks">Taxonomy</a>
|
||
<div class="brieflinkpop offscreen_noflow">Link to related taxonomy entry</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/variation/view/?q=11168[geneid]" ref="log$=recordlinks">Variation Viewer</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related Variants</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet dis-links-to-other-res brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Links to other resources</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_LinksTwo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_LinksTwo.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9527">HGNC</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://www.ensembl.org/id/ENSG00000164985">Ensembl</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.alliancegenome.org/gene/HGNC:9527">AllianceGenome</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?c=geneid&org=9606&l=11168">AceView</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=human&position=NM_033222">UCSC</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://genecollections.nci.nih.gov/MGC/?ORG=Hs&LIST=BC044568,BC064135">MGC</a>
|
||
</li>
|
||
<li>
|
||
<a href="http://www.genome.jp/dbget-bin/www_bget?hsa:11168">KEGG</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://reactome.org/content/query?q=UniProt:O75475">Reactome</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-general-info">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>General information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_GeneralInfo" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_GeneralInfo.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pmc/?term=PMC4383897+OR+PMC3013746+OR+PMC1761442+OR+PMC539985">About Gene</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3840">FAQ</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://ftp.ncbi.nlm.nih.gov/gene/">FTP site</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3841/">Help</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK3842/">My NCBI help</a>
|
||
</li>
|
||
<li>
|
||
<a href="/books/NBK21085/">NCBI Handbook</a>
|
||
</li>
|
||
<li>
|
||
<a href="/gene/statistics/">Statistics</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-related-sites">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related sites</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_RelatedSites" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_RelatedSites.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/BLAST">BLAST</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/genome">Genome</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/bioproject">BioProject</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/">Genome Data Viewer</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/geo">GEO</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/omim">OMIM</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/probe">Probe</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/RefSeq">RefSeq</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-feedback">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Feedback</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Feedback" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Feedback.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://support.ncbi.nlm.nih.gov/ics/support/ticketnewwizard.asp?style=classic&deptID=28049">Contact Help Desk</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/RefSeq/update.cgi?geneid=11168&symbol=PSIP1">Submit Correction</a>
|
||
</li>
|
||
<li>
|
||
<a href="/gene/submit-generif?geneId=11168&sym=PSIP1&name=PC4 and SRSF1 interacting protein 1&org=Homo sapiens">Submit GeneRIF</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet brieflink dis-subscription">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Subscription</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Gene_Subscription" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVFullReport.Gene_RightColumn.Gene_Subscription.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="https://www.ncbi.nlm.nih.gov/mailman/listinfo/refseq-announce">RefSeq</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<!-- <component id="Gene_RVFullReport.Gene_RightColMenuLinks"/>-->
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Recent activity</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<div id="HTDisplay" class="">
|
||
<input name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.Cmd" sid="1" type="hidden" />
|
||
<div class="action">
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.ClearHistory">
|
||
Clear
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn Off
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" sid="2" realname="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOff" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn On
|
||
</a>
|
||
</div>
|
||
<ul id="activity">
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67ca00cba68b6b5afc280113">PSIP1 PC4 and SRSF1 interacting protein 1 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">PSIP1 PC4 and SRSF1 interacting protein 1 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:11168</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67ca00c984f3725e59f4025d">PC4 and SFRS1-interacting protein isoform 1 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">PC4 and SFRS1-interacting protein isoform 1 [Homo sapiens]<div class="brieflinkpopdesc">gi|190014586|ref|NP_066967.3|</div></div>
|
||
<div class="tertiary">Protein</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67ca00c8a68b6b5afc27f321">POU2F2 POU class 2 homeobox 2 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">POU2F2 POU class 2 homeobox 2 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:5452</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
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<li class="ra_rcd ralinkpopper two_line">
|
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67ca00c6f4a390645ef7afbc">POU domain, class 2, transcription factor 2 isoform 2 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">POU domain, class 2, transcription factor 2 isoform 2 [Homo sapiens]<div class="brieflinkpopdesc">gi|4505959|ref|NP_002689.1|</div></div>
|
||
<div class="tertiary">Protein</div>
|
||
</li>
|
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<li class="ra_rcd ralinkpopper two_line">
|
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67ca00c4b15b832ebcc68ac6">PELO pelota mRNA surveillance and ribosome rescue factor [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">PELO pelota mRNA surveillance and ribosome rescue factor [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:53918</div></div>
|
||
<div class="tertiary">Gene</div>
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</li>
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