485 lines
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485 lines
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<div class="search"><form method="get" action="/biosample/"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="biosample" selected="selected">BioSample</option><option value="clinvar">ClinVar</option><option value="dbvar">dbVar</option><option value="snp" class="last">SNP</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene">Gene</option><option value="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search BioSample" value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="isEnabled:false,disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'no',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div></form><ul class=" inline_list searchlinks"><li>
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<div class="col1">
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<div id="str" class="lineheight2em">
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<h1>Authenticated Cell Lines</h1>
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<h2>Why is cell line authentication important?</h2>
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<p>
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Contaminated and misidentified cell lines are a serious and pervasive problem in the research community.
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A cell line becomes misidentified through cross-contamination, mislabeling, or other laboratory errors,
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meaning that it no longer corresponds to the original donor and may in fact come from an entirely
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different species, tissue or disease. Consequently, data derived from misidentified cell lines can be
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misleading or false, and cause confusion in the scientific literature. To address this issue, a
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growing number of journals and funding agencies now require researchers to authenticate their cell
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lines using an accepted consensus method, such as short tandem repeat (STR) profiling.
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</p>
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<p>
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The <a href="http://iclac.org/resources/">International Cell Line Authentication Committee (ICLAC)</a>
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provides many resources and best practice guidelines for researchers, including a curated register
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of cell lines already known to be misidentified or contaminated.
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</p>
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<p>In summary, to reduce the impact of misidentified cell lines, ICLAC recommends:</p>
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<ol>
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<li>Check the register of known misidentified cell lines before starting work</li>
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<li>Incorporate authentication testing into everyday culture practice</li>
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<li>Report testing as an essential part of publications and grant applications</li>
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</ol>
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<h2>How can I find out if my cell line is already known to be misidentified? </h2>
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<p>
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Check the <a href="http://iclac.org/databases/cross-contaminations/">ICLAC register of known misidentified cell lines</a>.
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The full dataset can be downloaded from ICLAC website directly. It is also disseminated via multiple
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resources, including here in the BioSample database
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(<a href="/biosample?term=misidentified+cell+line%5bFilter%5d">browse misidentified cell lines</a>).
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To search the register in BioSample, enter your cell line name into this box:
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</p>
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<form id="misidentified_form">
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<input type="text" name="term" placeholder="cell line name or keyword" />
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<input type="submit" value="Search" class="jig-ncbibutton" id="misidentified_search_button" />
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</form>
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<h2>How can I find STR calls for my cell line? </h2>
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<p>
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The first place to check is the repository from which your cell line was originally purchased.
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Alternatively, the BioSample database stores STR profiles and descriptions for several thousand
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cell lines, as provided by cell line repositories
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(<a href="/biosample?term=human+str+profile%5bFilter%5d">browse cell lines with STR profiles</a>).
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To search STR data for your cell line in BioSample, enter your cell line name into this box:
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</p>
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<form id="str_calls_form">
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<input type="text" name="term" placeholder="cell line name or keyword" />
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<input type="submit" value="Search" class="jig-ncbibutton" id="str_calls_search_button" />
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</form>
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<h2>I’m a researcher and I’ve generated STR calls for the cell line I’m using.
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How can I determine if my STR calls match the calls generated by the cell line repository? </h2>
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<p>
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At this time, there is no mechanism to perform direct matching or comparisons of the STR profiles
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in the BioSample database with user input data. Instead, we recommend the
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<a href="https://www.atcc.org/STR_Database.aspx" class="match_tool">ATCC STR matching tool</a> and the
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<a href="https://www.dsmz.de/services/services-human-and-animal-cell-lines/online-str-analysis.html" class="match_tool">DSMZ STR matching tool</a>
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to help you find the best matches between your STR calls and cell lines in those databases.
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Alternatively, you can consult the
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<a href="http://iclac.org/resources/match-criteria-worksheet/" class="match_tool">ICLAC Match Criteria Worksheet</a>
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to determine if STR profiles from two cell lines are related.
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</p>
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<h2>I represent a cell line repository. How can I submit cell line descriptions,
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electropherogram images and STR calls to the BioSample database? </h2>
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<p>
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Cell line repositories can contribute to this collection and deposit cell line descriptions,
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authenticated STR calls and electropherogram images to the BioSample database using this
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<a href="/biosample/docs/templates/NCBI_HumanCellLineStrProfile_SubmissionTemplate.xlsx">STR submission template</a>.
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Full instructions are provided within the template.
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If you have any questions about the procedure,
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please <a href="mailto:biosamplehelp@ncbi.nlm.nih.gov">contact the BioSample help team</a>.
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</p>
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