556 lines
30 KiB
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556 lines
30 KiB
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<!-- PubChem template version 5.1 2012-05 -->
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<!-- $Id: about.html 367034 2012-06-20 14:44:12Z jiazhang $ -->
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<html xmlns="http://www.w3.org/1999/xhtml">
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<head xmlns:xi="http://www.w3.org/2001/XInclude">
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<meta content="text/html; charset=utf-8" http-equiv="Content-Type" />
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<meta name="description" content="VAST Search, a tool that allows you to input the spatial coordinates of a 3D macromolecular structure in PDB format and retrieve similar 3D structures. Developed by the National Center for Biotechnology Information's Structure Group." />
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<meta name="ncbi_db" content="pubchem" />
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<meta name="keywords" content="Vector Alignment Search Tool (VAST), 3D macromolecular structures, three-dimensional structures, 3D, 3-D, structural alignments, similar structures, superpose, superpositions, superimpose, superimposition, proteins, chemicals, nucleotide sequences, x-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, nucleic acids, DNA, RNA, ligands, bound chemicals, drugs, medicine, Entrez Structure, Molecular Modeling Database (MMDB), VAST+, Conserved Domains Database (CDD), CDTree, CD Tree, PubChem, NCBI, National Center for Biotechnology Information" />
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<meta name="robots" content="index,follow,noarchive" />
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<title>VAST Search</title>
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<!-- ======= END_GET_PUBCHEM_HEADER_AND_NCBILOCALNAV_PULLDOWN_MENUS ========= -->
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<!-- ==================== VERTICAL SPACER ======================= -->
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<TABLE style="margin:0px 0px 0px 0px;" width="100%" border="0" cellspacing="0" cellpadding="0">
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<TR>
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<TD class="WhiteCell MiniText"> </TD>
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</TR>
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</TABLE>
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<!-- ==================== END_VERTICAL SPACER ======================= -->
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<!-- ##################### BEGIN_EDITABLE_CONTENT ##################### -->
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<A NAME="3"></A>
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<!-- ######### BEGIN_BLUE_EDGE_BOX_WITH_TITLE_OF_DOCUMENT ######## -->
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<TABLE style="margin:0px 0px 0px 0px;" class="NormalText" width="100%" border="0" cellspacing="0" cellpadding="0" bgcolor="#FFFFFF">
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<TR>
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<!-- ==================== TITLE_OF_DOCUMENT =================== -->
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<TABLE style="margin:0px 0px 0px 0px;" width="100%" border="0" cellspacing="0" cellpadding="0" bgcolor="#FFFFFF">
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<TR>
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<TD class="DocTitleText" align="left"> <A HREF="../vast.shtml">VAST: <SPAN class="DocTitleTextSmall13">Vector Alignment Search Tool</SPAN></A></TD>
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<!-- ===================== GREEN_BUTTONS ====================== -->
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<TD width="350" bgcolor="#FFFFFF">
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<TABLE width="350" border="0" style="border-collapse:separate;" cellspacing="1" cellpadding="0" bgcolor="#FFFFFF">
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<TR>
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<TD class="NavResourceButtonInactive" align="center" valign="center" style="white-space: nowrap;"><A href="vast.shtml"> ABOUT </A></TD>
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<!-- TD class="NavResourceButtonInactive" align="center" valign="center" style="white-space: nowrap;"><A href="../MMDB/docs/mmdb_how_to.html#VAST"> HOW TO </A></TD -->
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<TD class="NavResourceButtonActive" align="center" valign="center" style="white-space: nowrap;"><A href="vastsearch.html"> SEARCH </A></TD>
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<TD class="NavResourceButtonInactive" align="center" valign="center" style="white-space: nowrap;"><A href="vasthelp.html"> HELP </A></TD>
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<!-- TD class="NavResourceButtonInactive" align="center" valign="center" style="white-space: nowrap;"><A href="vastsrchelp.html"> VAST SEARCH HELP </A></TD -->
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<!-- TD class="NavResourceButtonInactive" align="center" valign="center" style="white-space: nowrap;"><A href="../vastplus/docs/vastplus_help.html"> VAST+ HELP </A></TD -->
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<TD class="NavResourceButtonInactive" align="center" valign="center" style="white-space: nowrap;"><A href="nrpdb.html"> nr-PDB </A></TD>
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<TD class="NavResourceButtonInactive" align="center" valign="center" style="white-space: nowrap;"><A href="docs/vast_publications.html"> PUBLICATIONS </A></TD>
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<TD class="NavResourceButtonInactive" align="center" valign="center" style="white-space: nowrap;"><A HREF="../MMDB/mmdb.shtml" title="Overview of macromolecular resources available from the NCBI Structure Group"> RESOURCES </A></TD>
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<TD class="NavResourceButtonInactive" align="center" valign="center" style="white-space: nowrap;"><A href="../MMDB/docs/mmdb_news.html" title="News about the macromolecular resources available from the NCBI Structure Group"> NEWS </A></TD>
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<TD class="NavResourceButtonInactive" align="center" valign="center" style="white-space: nowrap;"><A HREF="../structure_discover.html" title="Discover associations among protein sequence, function, and structure"> DISCOVER </A></TD>
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<TD class="WhiteCell" width="1"> </TD>
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<TR>
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</TABLE>
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<TD class="MiniText" width="5"> </TD>
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</TABLE>
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<!-- ==================== VERTICAL SPACER ======================= -->
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<TABLE width="100%" border="0" cellspacing="0" cellpadding="0">
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<TR>
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<TD class="WhiteCell MicroText"> </TD>
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</TR>
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</TABLE>
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<!-- ================== END_VERTICAL SPACER ===================== -->
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<!-- the contents -->
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<TABLE style="margin:0px 0px 0px 0px;" width="100%" border="0" cellspacing="0" cellpadding="0" bgcolor="#FFFFFF">
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<TD class="WhiteCellWithPadding" ALIGN="LEFT" VALIGN="TOP">
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<!-- ======================== BOX1 =========================== -->
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<TABLE style="margin:0px 0px 0px 0px;" width="100%" border="0" cellspacing="0" cellpadding="0" class="WhiteCellBlueEdgeAll">
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<!-- ########## WHITE_HEADER ########## -->
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<TR>
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<TD class="WhiteCell" ALIGN="LEFT" VALIGN="TOP">
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<SPAN class="MiniText"> <BR></SPAN>
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<P class="indent10 TOCText2">There are several ways to retrieve similar 3D structures<!-- that are similar in 3D shape to a query structure -->:</P></TD>
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</TR>
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<!-- ########## END_WHITE_HEADER ########## -->
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<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
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<TD class="WhiteCell MiniText" ALIGN="Center" VALIGN="TOP"> </TD>
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</TR>
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<!-- TR>
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<TD class="WhiteCell TOCText" ALIGN="LEFT" VALIGN="TOP">
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<P class="indent10 NormalText">Description of <A HREF="___">resource</A> text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text.</P>
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</TD>
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</TR -->
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<!-- TR>
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<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> </TD>
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</TR -->
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<TR>
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<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP">
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<TABLE style="margin:0px 0px 0px 0px;" width="100%" border="0" cellspacing="0" cellpadding="0" class="WhiteCell">
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<!-- ================ INPUT_PDB_FORMAT_FILE ===================== -->
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<TR>
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<TD width="10" class="WhiteCell TOCText" ALIGN="LEFT" VALIGN="TOP">
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 </TD>
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<TD width="250" class="WhiteCell TOCText2" ALIGN="LEFT" VALIGN="TOP">
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<A NAME="InputPDBFormatFile"></A>Input a PDB-formatted file<BR> directly into <B>VAST Search</B></TD>
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<TD width="5" class="WhiteCell TOCText" ALIGN="LEFT" VALIGN="TOP">
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 </TD>
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<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
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<!-- VAST Search is NCBI's structure-structure similarity search service.
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It compares 3D coordinates of a newly determined protein structure to those
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in the MMDB/PDB database. VAST Search computes a list of structure neighbors
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that you may browse interactively, viewing superpositions and alignments
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by molecular graphics. From this page, you can either start a new Vast Search
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or retrieve the Vast Search results for previously submitted jobs.<BR><BR -->
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The <B>VAST Search</B> service is a web-based tool that allows you to compare the spatial coordinates of a newly resolved 3D structure against all structures in the <A HREF="https://www.ncbi.nlm.nih.gov/structure/">Molecular Modeling Database (MMDB)</A>. To use the service, place your data into a <A HREF="vastsrchelp.html#Submission">text file</A> using
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<!-- a href="http://www.rcsb.org/pdb/" --><!-- A HREF="http://www.wwpdb.org/docs.html" --><A HREF="http://www.wwpdb.org/documentation/file-format">PDB File format</a>. Use the "choose file" button below to browse your computer and select the data file, and select the <a href="vasthelp.html#VASTNR">data set</a> (all or medium redundancy) against which you want to search. Click the "Submit" button to begin the search. The <A HREF="vastsrchelp.html"><B>VAST Search help document</B></A> provides additional details about <A HREF="#Submission">submitting a query</A>. The main <A HREF="vasthelp.html">VAST Help document</A> provides general information <A HREF="vasthelp.html#WhatIs">about VAST</A>, <A HREF="vasthelp.html#OriginalVAST">illustrated examples of the output</A>, and links to <A HREF="docs/vast_publications.html">publications</A> that describe the <A HREF="vasthelp.html#WhatIs">VAST algorithm</A>.<BR><BR>
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<form method=post enctype=multipart/form-data action="../vast/VSMmdb.cgi" name="newvs">
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<!-- form method=get action="VSMmdb.cgi" -->
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<table cellspacing=0 border=0 width=600>
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<tr>
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<td class="NormalText">
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<input type=submit name=cmdVSMmdb value=Submit>
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<b> PDB file: </b>
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</td>
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<td class="NormalText"> <input type=file name=pdbfile value=1abc.pdb></td>
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</tr>
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<tr><td> </td></tr>
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<tr>
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<td class="NormalText" width=170><b>Searching against:</b></td>
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<td class="NormalText" valign="top"><input type=radio name=dataset value="Non-redundant subset" checked> Medium-redundancy Subset of PDB
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<a href="vasthelp.html#VASTNR"><img SRC="https://www.ncbi.nlm.nih.gov/Structure/vast/HTML_dir/infosmall.gif" border=0></a>
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</td>
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</tr>
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<tr>
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<td> </td>
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<td class="NormalText"><input type=radio name=dataset value=All>All of PDB </td>
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</tr>
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</table>
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</form>
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<I>(Please note that the VAST Search service returns results in the <A HREF="vasthelp.html#OriginalVAST">Original VAST output format</A>. The new <A HREF="../vastplus/docs/vastplus_help.html#IllustratedExamples">VAST+ output format</A> is currently available only for structures that are publicly available in MMDB. Read more about the <A HREF="../vastplus/docs/vastplus_help.html#Compare">differences between VAST and VAST+</A>)</I>
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<BR><BR>
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</TD>
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<TD width="5" class="WhiteCell TOCText" ALIGN="LEFT" VALIGN="TOP">
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 </TD>
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</TR>
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<TR>
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<TD colspan="5" class="WhiteCell MiniText" ALIGN="LEFT" VALIGN="TOP"> </TD>
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</TR>
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<!-- ================ INPUT_VAST_REQUEST_ID_RID ===================== -->
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<TR>
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<TD width="10" class="WhiteCell TOCText" ALIGN="LEFT" VALIGN="TOP">
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 </TD>
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<TD width="250" class="WhiteCell TOCText2" ALIGN="LEFT" VALIGN="TOP">
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<A NAME="InputRID"></A><A NAME="ChkRes"></A>Retrieve the results<BR> of a previous <B>VAST Search</B></TD>
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<TD width="5" class="WhiteCell TOCText" ALIGN="LEFT" VALIGN="TOP">
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 </TD>
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<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
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<P class="NormalText">To get results of a previous job, please enter its
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<a href="vsprivacy.html">request identifier</a>,
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a number you received when submitting the previous search,
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in the following line and click the "Show" button.
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<br><br>
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<form method=post enctype=multipart/form-data action="../vast/VSMmdb.cgi" name="newvs">
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<!-- form method=get action="VSMmdb.cgi" -->
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<table cellspacing=0 border=0 width=600>
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<tr>
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<td class="NormalText">
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<input type=submit name=submit value=Show>
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<input type=hidden name=cmdVSMmdb value=StrText>
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<b> Retrieve result by request ID: </b>
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<input type=text name=grpid>
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</td>
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</tr>
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</table>
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</form>
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</TD>
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<TD width="5" class="WhiteCell TOCText" ALIGN="LEFT" VALIGN="TOP">
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 </TD>
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</TR>
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<TR>
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<TD colspan="5" class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP"> </TD>
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</TR>
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<TR>
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<TD colspan="5" class="WhiteCell MiniText" ALIGN="LEFT" VALIGN="TOP"> </TD>
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</TR>
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<!-- ================ INPUT_ENTREZ_SEARCH ===================== -->
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<TR>
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<TD width="10" class="WhiteCell TOCText2" ALIGN="LEFT" VALIGN="TOP">
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 </TD>
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<TD width="250" class="WhiteCell TOCText2" ALIGN="LEFT" VALIGN="TOP">
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<A NAME="InputEntrezStructureRecord"></A>Retrieve a 3D Structure record from <A HREF="https://www.ncbi.nlm.nih.gov/structure/"><B>MMDB</B></A> → link to similar structures</TD>
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<TD width="5" class="WhiteCell TOCText" ALIGN="LEFT" VALIGN="TOP">
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 </TD>
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<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">If your structure of interest is already available in the <A HREF="https://www.ncbi.nlm.nih.gov/structure/">Molecular Modeling Database (MMDB)</A>, a VAST search has been conducted and the precalculated <A HREF="vast.shtml">VAST</A>, and <A HREF="../vastplus/vastplus.cgi">VAST+</A>, results are accessible from the structure's summary page. To view the precalculated results:<BR><BR>
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(1) <!-- A HREF="../MMDB/docs/mmdb_help.html#SearchTips" --><A HREF="https://www.ncbi.nlm.nih.gov/structure/">Retrieve</A> a structure record of interest by PDB ID, MMDB ID, or text term.<BR><BR>
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(2) Open its <A HREF="../MMDB/docs/mmdb_help.html#SummaryPage">structure summary page</A>.<BR><BR>
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(3) Click on the "<A HREF="../MMDB/docs/mmdb_help.html#MmdbsrvSimilarStructures"><B>Similar Structures: VAST+</B></A>" link near the upper right corner of the summary page. That will open the new <A HREF="../vastplus/vastplus.cgi"><B>VAST+</B></A> search results page<!-- (<A HREF="../vastplus/docs/vastplus_help.html#IllustratedExamples"><I><span style="color:#d70000">illustrated example</span></I></A>) -->, which lists the query structure followed by similar structures, ranked by the degree of similarity to the query structure's <A HREF="../vastplus/docs/vastplus_help.html#OutputBiologicalUnit">biological unit</A>.<BR><BR> As a shortcut to the VAST+ results for your structure of interest, simply enter its PDB ID or MMDB ID in the form below:<BR><BR>
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<!-- OLD CODE FOR THIS FORM -->
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<!-- FORM METHOD="post" ACTION="/Structure/mmdb/mmdbsrv.cgi">
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<B>Show "Similar Structures: VAST+" for PDB ID or MMDB ID:</B>
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<INPUT TYPE="text" NAME="uid" SIZE=6>
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<INPUT TYPE="hidden" NAME="ShowOp" VALUE="VastSum">
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<INPUT TYPE="submit" NAME="submit" VALUE=" Go ">
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</FORM -->
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<table border="0" width="100%" cellspacing="0" cellpadding="0" class="NormalText">
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<tr valign="top">
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<td class="NormalText" align="LEFT">
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<FORM METHOD="post" ACTION="/Structure/vastplus/vastplus.cgi">
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<B>Show Similar Structures for:</B>
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<INPUT TYPE="text" NAME="uid" SIZE=15 placeholder="PDB ID or MMDB ID">
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<INPUT TYPE="hidden" NAME="style" VALUE="old">
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<INPUT TYPE="submit" NAME="submit" VALUE="Go">
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<INPUT TYPE="reset" NAME="reset" VALUE="Clear">
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</FORM>
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</td>
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</tr>
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</table>
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<BR>
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If you prefer to see the <A HREF="../vastplus/docs/vastplus_help.html#OriginalVAST"><B>original VAST</B></A> results<!-- (<A HREF="../vastplus/docs/vastplus_help.html#OriginalVASTDisplay"><I><span style="color:#d70000">illustrated example</span></I></A>) -->, which focus on similarities between individual protein molecules or 3D domains within the query structure and hits, then click on the <A HREF="../vastplus/docs/vastplus_help.html#OriginalVAST"><B>"Original VAST" button</B></A> near the upper right corner of the <A HREF="../vastplus/vastplus.cgi">VAST+</A> search results page.<!-- That will open a dialog box listing the individual [<A HREF="../MMDB/docs/mmdb_help.html#MmdbsrvProteinsShowAnnotation">]<A HREF="../MMDB/docs/mmdb_help.html#MmdbsrvProteins">protein molecules</A> that compose the structure, and the <A HREF="../MMDB/docs/mmdb_help.html#MmdbsrvProteins3dDomains">3D domains</A> detected in each one. Select a protein molecule or 3D domain of interest to view a list of other structures that are similar in shape to the molecule or 3D domain you selected. -->
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<BR>
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Alternatively, you can access original VAST results for individual proteins within your query structure by following these steps: open the query structure's <A HREF="../MMDB/docs/mmdb_help.html#SummaryPage">summary page</A>; scroll down to the <A HREF="../MMDB/docs/mmdb_help.html#MmdbsrvMolecularComponents">table of <B>molecules and interactions</B></A>; view the <A HREF="../MMDB/docs/mmdb_help.html#MmdbsrvProteinsShowAnnotation">"<B>show annotation</B>" graphic</A> for any protein molecule of interest; then <B>click on the bar graphic</B> for the overall <!-- A HREF="../MMDB/docs/mmdb_help.html#MmdbsrvProteinsShowAnnotation" --><A HREF="../MMDB/docs/mmdb_help.html#MmdbsrvProteins">protein molecule</A> or for any <A HREF="../MMDB/docs/mmdb_help.html#MmdbsrvProteins3dDomains">3D domain</A> it contains. That will display a list of other structures that are similar in shape to the specific molecule or 3D domain you selected;
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<BR><BR>
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The <A HREF="../vastplus/docs/vastplus_help.html">VAST+ help document</A> provides details about the <A HREF="../vastplus/docs/vastplus_help.html#Compare">differences between VAST and VAST+</A>, an <A HREF="../vastplus/docs/vastplus_help.html#IllustratedExamples"><I><span style="color:#d70000">illustrated example</span></I> of VAST+ results</A>, and an <A HREF="../vastplus/docs/vastplus_help.html#OriginalVASTDisplay"><I><span style="color:#d70000">illustrated example</span></I> of original VAST results</A>.
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<!-- UL>
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<LI><A HREF="#InputEntrezStructureToVASTstructures">3D structure → similar 3D structures</A></LI>
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<LI><A HREF="#InputEntrezProteintoStructuretoVASTstructures">protein sequence → source 3D structure → similar 3D structures</A></LI>
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<LI><A HREF="#InputEntrezProteintoCBLASTStructuretoVASTstructures">protein sequence → sequence-similar 3D structures (CBLAST "related structures") → (VAST) similar structures</A></LI>
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</UL -->
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<!-- TABLE CLASS="WhiteCell NormalText" WIDTH="100%" BORDER="0" CELLSPACING="0" CELLPADDING="0" BGCOLOR="#FFFFFF">
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<TR>
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<TD WIDTH="___" CLASS="___" ALIGN="LEFT" VALIGN="TOP"><A HREF="vast_help.html#InputEntrezStructureToVASTstructures">3D structure → similar structures</A></TD>
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<TD WIDTH="___" CLASS="___" ALIGN="LEFT" VALIGN="TOP"> </TD>
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<TD WIDTH="___" CLASS="___" ALIGN="LEFT" VALIGN="TOP"><A HREF="vast_help.html#InputEntrezProteintoStructuretoVASTstructures">protein sequence → [source 3D] structure → similar structures</A></TD>
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<TD WIDTH="___" CLASS="___" ALIGN="LEFT" VALIGN="TOP"> </TD>
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<TD WIDTH="___" CLASS="___" ALIGN="LEFT" VALIGN="TOP"><A HREF="vast_help.html#InputEntrezProteintoCBLASTStructuretoVASTstructures">protein sequence → [sequence-similar 3D] {{CBLAST related structures}} → (VAST) similar structures</A></TD>
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<TD WIDTH="___" CLASS="___" ALIGN="LEFT" VALIGN="TOP"> </TD>
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</TABLE -->
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<TD colspan="5" class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP"> </TD>
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<!-- ================ INPUT_IBIS_SEARCH ===================== -->
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 </TD>
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<TD width="250" class="WhiteCell TOCText2" ALIGN="LEFT" VALIGN="TOP">
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<A NAME="InputIBISSearch"></A><A HREF="https://www.ncbi.nlm.nih.gov/Structure/ibis/ibis.cgi"><B>IBIS</B></A> <A HREF="https://www.ncbi.nlm.nih.gov/protein/">protein</A> or <A HREF="https://www.ncbi.nlm.nih.gov/structure/">structure</A> query → retrieve related/similar structures,<BR>clustered by binding site similarity</TD>
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<TD width="5" class="WhiteCell TOCText" ALIGN="LEFT" VALIGN="TOP">
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 </TD>
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<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">Open the <SPAN class="ThumbText"><A HREF="_______"><B>___RESOURCE_NAME___</B></A></SPAN> home page to text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text text.</TD>
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<TD colspan="5" class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP"> </TD>
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<TD colspan="5" class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP"> </TD>
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<!-- ================ INPUT_TEMPLATE ===================== -->
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 </TD>
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<TD width="250" class="WhiteCell TOCText2" ALIGN="LEFT" VALIGN="TOP">
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<A NAME="_______">____header_____</A></TD>
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<TD width="5" class="WhiteCell TOCText" ALIGN="LEFT" VALIGN="TOP">
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 </TD>
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<TD class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP">
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Use the <SPAN class="ThumbText"><A HREF="________"><B>______</B></A></SPAN> program to upload the ______ <SPAN class="ThumbText"><A HREF="http://www.rcsb.org/pdb/"><B>PDB format</B></A></SPAN> and _______.</TD>
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<TD colspan="5" class="WhiteCell NormalText" ALIGN="LEFT" VALIGN="TOP"> </TD>
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<TD colspan="5" class="WhiteCell MiniText" ALIGN="LEFT" VALIGN="TOP"> </TD>
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</TR -->
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<TD width="10" class="WhiteCell ThumbText2" ALIGN="LEFT" VALIGN="TOP">
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 </TD>
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<TD colspan="3" class="WhiteCell ThumbText2" ALIGN="LEFT" VALIGN="TOP">
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The "<a href="../MMDB/docs/mmdb_how_to.html#VAST"><B>How To</B></a>" page provides <a href="vast_how_to.html"><B>quick start guides</B></a> for some common types of searches, and the VAST <a href="vasthelp.html"><B>Help document</B></a> provides detailed descriptions of the [input required, output displays, and the] program's features and functions. [Once records of interest are retrieved, follow Entrez's "Links" to <a href="../../structure_discover.html"><B>discover associations among previously disparate data</B></A>.]</TD>
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<TD width="5" class="WhiteCell ThumbText2" ALIGN="LEFT" VALIGN="TOP">
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<!-- ======================== END_BOX1 =========================== -->
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<!-- ================== END_VERTICAL SPACER ===================== -->
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<!-- ########## BLUE_HEADER ########## -->
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<TD class="SteelBlueCell HeaderText2B" ALIGN="LEFT" VALIGN="TOP">__________________________________</TD>
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</TR -->
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<!-- ########## END_BLUE_HEADER ########## -->
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<TABLE style="margin:0px 0px 0px 0px;" width="100%" border="0" cellspacing="0" cellpadding="0" class="WhiteCell NormalText">
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<TD class="WhiteCell" WIDTH="15" ALIGN="Center" VALIGN="TOP"> </TD>
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<TD class="WhiteCell NormalText" ALIGN="Left" VALIGN="TOP">
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Text text text text...<BR><BR>
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Text text text text...<BR><BR>
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</TD>
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<TD class="WhiteCell" WIDTH="15" ALIGN="Center" VALIGN="TOP"> </TD>
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<TD class="WhiteCell" WIDTH="15" ALIGN="Center" VALIGN="TOP"> </TD>
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<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP">
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<img src="________.png" width="500" height="100"><BR><BR>
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</TD>
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<TD class="WhiteCell" WIDTH="15" ALIGN="Center" VALIGN="TOP"> </TD>
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<TD class="WhiteCell" WIDTH="15" ALIGN="Center" VALIGN="TOP"> </TD>
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<TD class="WhiteCell NormalText" ALIGN="Left" VALIGN="TOP">
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Text text text text...<BR><BR>
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Text text text text...<BR><BR>
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</TD>
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<TD class="WhiteCell" WIDTH="15" ALIGN="Center" VALIGN="TOP"> </TD>
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</TR>
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<TD class="WhiteCell NormalText" ALIGN="Center" VALIGN="TOP"> 
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<BR> <BR></TD>
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<!-- ============== END_CONTENT_AREA_ROW_1_CELL_1 ================= -->
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<!-- ############ END_BLUE_EDGE_BOX_WITH_TITLE_OF_DOCUMENT ######## -->
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<!-- =================== PAGE_FOOTER_AND_DATE_REVISED ================== -->
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<TABLE style="margin:0px 0px 0px 0px;" width="100%" border="0" cellspacing="0" cellpadding="0">
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<TD VALIGN="top" ALIGN="RIGHT"><SPAN CLASS="HELPBAR1" STYLE="color="#646464"">Revised 26 September 2016</SPAN></TD>
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<TD width="25"><IMG SRC="https://www.ncbi.nlm.nih.gov/coreweb/template1/pix/pixel.gif" width="1" height="1" alt="" border=0></TD>
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<!-- ##################### END_EDITABLE_CONTENT ##################### -->
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<script type="text/javascript">doc_tmp.getDocFtr('<A HREF="https://www.ncbi.nlm.nih.gov/research/">Computational Biology Branch</A> > <A HREF="https://www.ncbi.nlm.nih.gov/Structure/index.shtml">Structure Group</A> > <A HREF="https://www.ncbi.nlm.nih.gov/Structure/MMDB/mmdb.shtml">Macromolecular Structures</A> > <A HREF="https://www.ncbi.nlm.nih.gov/Structure/VAST/vast.shtml">VAST</A> > VAST Search','other');</script>
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<!-- script type="text/javascript">doc_tmp.getDocFtr(' > <A HREF="______">__________</A> > <A HREF="______">__________</A> > <A HREF="______">__________</A> > ___currentpage_____', 'other');</script -->
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