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<TITLE>Expired NOT-DA-21-017: Notice of Special Interest (NOSI): Medical Consequences of Smoking and Vaping Drugs of Abuse in Individuals with HIV and COVID-19</TITLE>
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<META NAME="description" CONTENT="NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Special Interest (NOSI): Medical Consequences of Smoking and Vaping Drugs of Abuse in Individuals with HIV and COVID-19 NOT-DA-21-017. NIDA">
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<META NAME="Keywords" CONTENT="NOT-DA-21-017: Notice of Special Interest (NOSI): Medical Consequences of Smoking and Vaping Drugs of Abuse in Individuals with HIV and COVID-19">
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<div class="noticeBar">This notice has expired. Check the <a href="https://grants.nih.gov/funding/searchguide/">NIH Guide</a> for active opportunities and notices.</div>
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<p id="watermark_text">EXPIRED</p>
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<span class="title">Notice of Special Interest (NOSI): Medical Consequences of Smoking and Vaping Drugs of Abuse in Individuals with HIV and COVID-19</span>
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Notice Number:
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<div data-element-id="25861" data-element-has-label="true" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
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<span class="noticenum">NOT-DA-21-017</span>
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<a name="_Key_Dates"></a><h2 class="heading2">Key Dates</h2>
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Release Date:
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<p class="Normal">February 4, 2021 </p>
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First Available Due Date:
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May 05, 2021
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Expiration Date:
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September 08, 2024
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<a name="_"></a><h2 class="heading2">Related Announcements</h2>
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</div>
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<p class="Normal"><a href="https://grants.nih.gov/grants/guide/pa-files/PA-20-184.html">PA-20-184 </a>- Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)</p>
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<p class="Normal"><a href="https://grants.nih.gov/grants/guide/pa-files/PA-20-183.html">PA-20-183 </a>- Research Project Grant (Parent R01 Clinical Trial Required)</p>
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<p class="Normal"><a href="https://grants.nih.gov/grants/guide/pa-files/PA-20-200.html">PA-20-200 </a>- NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)</p>
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<p class="Normal"><a href="https://grants.nih.gov/grants/guide/pa-files/PA-20-195.html">PA-20-195 </a>- NIH Exploratory/Developmental Research Grant (Parent R21 Clinical Trial Not Allowed)</p>
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<p class="Normal"><a href="https://grants.nih.gov/grants/guide/pa-files/PA-20-194.html">PA-20-194</a> - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)</p>
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<p class="Normal"><a href="https://grants.nih.gov/grants/guide/pa-files/PA-20-196.html">PA-20-196</a> - NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required)</p>
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<a name="_"></a><h2 class="heading2">Issued by</h2>
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<p>National Institute on Drug Abuse (<a href="https://www.drugabuse.gov/" target="_blank">NIDA</a>)
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</div>
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<a name="_"></a><h2 class="heading2">Purpose</h2>
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<p class="Normal"><b></span> </b></p>
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<p class="Normal"><b>Background</b>: Tobacco use, particularly cigarette smoking, is a leading lifestyle-related cause of death in the United States. HIV-positive individuals who smoke experience higher morbidity and mortality compared to HIV-positive nonsmokers. Smoking is significantly associated with a greater risk for cardiovascular disease and non-AIDS malignancies, including non-AIDS-related cancers. Among HIV-positive people on antiretroviral therapy, HIV-positive smokers have a two-fold increase in mortality, compared to HIV-positive nonsmokers. Vaping is becoming highly prevalent, particularly among teenagers and young adults. Teenagers and young adults who vaped were 5-7 times more likely to be infected with SARS-CoV2 than those who did not use e-cigarettes.</p>
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<p class="Normal">COVID-19 can severely affect cardiovascular, respiratory, renal, gastrointestinal, hematological, immunological, and central (CNS) and peripheral nervous systems (PNS) with long-term consequences yet to be fully known or understood. Hypercoagulability, cardiomyopathy, pneumonia, inflammatory lympho-/chemokine storm, diarrhea, renal failure, Guillain-Barre syndrome, transverse myelitis, psychosis and coma have been caused by SARS-CoV2.</p>
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<p class="Normal">People living with HIV are recognized as being at potentially greater risk for severe COVID-19 by the CDC though data are still scant. Thus, it is of public health relevance to understand the potential deleterious effects of smoking and vaping in among individuals with HIV who had been infected with the SARS-CoV2. Thanks to significant investments in electronic health records (EHR) over the past years and the establishment of large databases, data mining strategies can be employed to facilitate research into the smoking and vaping/COVID 19/HIV syndemic.</p>
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<p class="Normal"><b>Rationale</b>: In the midst of the COVID-19 pandemic, HIV clinical research and medical care have been negatively impacted. “Stay-at-home” recommendations, solitude, unemployment, lack of medical resources, distress, and sickness have all raised the level of anxiety, with consequent reinforcement of addictive behaviors, like smoking or vaping tobacco, marijuana, cocaine, and/or methamphetamine. The long-term effects of COVID-19 disease are not known. Recent studies suggest possible pathogenic roles between nicotine and angiotensin-2 receptors, investigations which are critical for understanding the pathogenesis of COVID-19. Thus, it is scientifically justified to study whether and how smoking and/or vaping addictive substances impact on the morbidity and mortality of people with HIV and SARS-CoV2 co-infection. Large COVID-19 datasets already exist to facilitate this research.</p>
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<p class="Normal"><b>Research Objectives: </b>NIDA is interested in receiving research applications focusing on individuals with HIV who smoke or vape marijuana, tobacco, cocaine and/or methamphetamine to determine the long-term effects of their use among individuals with HIV and COVID-19.</p>
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<p class="Normal"><b>Research Areas: </b></p>
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<ul>
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<li class="Normal" style="list-style-type: disc;">The <b>risks </b>that smoking and/or vaping tobacco, marijuana, cocaine, and/or methamphetamine may have on acquiring the SARS-CoV2 infection in individuals with HIV.</li>
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<li class="Normal" style="list-style-type: disc;"><b>The medical consequences, co-morbidity, and complications</b> of SARS-CoV2 infection affecting <b>cardiovascular, respiratory, renal, gastrointestinal, hematological, immunological, CNS and PNS systems</b> in HIV individuals who smoke and/or vape tobacco, marijuana, cocaine, and/or methamphetamine.</li>
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<li class="Normal" style="list-style-type: disc;"><b>Defining mechanisms</b> by which substance use and HIV interact to increase susceptibility to severe COVID-19 affecting <b>cardiovascular, respiratory, renal, gastrointestinal, hematological, immunological, CNS and PNS</b> morbidity.</li>
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<li class="Normal" style="list-style-type: disc;"><b>Utilization of large database- Electronic Health Records – strategies </b>for retrospective and platform based prospective studies, cross analyses, and real-time health delivery and critical health-related decisions in emergency medicine settings.</li>
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</ul>
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<p class="Normal"><b>Investigators are encouraged to make use of existing data sets and resources.</b></p>
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<p class="Normal" style="margin: 0in 0in 7.5pt;"><b>Application and Submission Information</b></p>
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<p class="Normal" style="margin: 0in 0in 7.5pt;">This notice applies to due dates on or after May 5, 2021</span></span> and subsequent receipt dates through September 7</span></span>, 2024. </p>
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<p class="Normal" style="margin: 0in 0in 7.5pt;">Submit applications for this initiative using one of the following funding opportunity announcements (FOAs) or any reissues of these announcement through the expiration date of this notice.</p>
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<p class="Normal"><a href="https://grants.nih.gov/grants/guide/pa-files/PA-20-184.html">PA-20-184 </a>- Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)</p>
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<p class="Normal"><a href="https://grants.nih.gov/grants/guide/pa-files/PA-20-183.html">PA-20-183</a> - Research Project Grant (Parent R01 Clinical Trial Required)</p>
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<p class="Normal"><a href="https://grants.nih.gov/grants/guide/pa-files/PA-20-200.html">PA-20-200 </a>- NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed</p>
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<p class="Normal"><a href="//grants.nih.gov/grants/guide/pa-files/PA-20-146.html">PA-20-146</a> - NIH Small Research Grant Program (Parent R03 Clinical Trial Required)</p>
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<p class="Normal"><a href="https://grants.nih.gov/grants/guide/pa-files/PA-20-195.html">PA-20-195 </a>- NIH Exploratory/Developmental Research Grant (Parent R21 Clinical Trial Not Allowed)</p>
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<p class="Normal"><a href="https://grants.nih.gov/grants/guide/pa-files/PA-20-194.html">PA-20-194 </a>- NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)</p>
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<p class="Normal"><a href="https://grants.nih.gov/grants/guide/pa-files/PA-20-196.html">PA-20-196 </a>- NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required)</p>
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<p class="Normal" style="margin-right: 0in; margin-left: 0in;">All instructions in the <a href="https://grants.nih.gov/grants/how-to-apply-application-guide.html">SF424 (R&R) Application Guide</a> and the funding opportunity announcement used for submission must be followed, with the following additions:</p>
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<li class="Normal" style="margin-right: 0in;">For funding consideration, applicants must include “NOT-DA-21-017” (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative.</li>
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<p class="Normal"><span style="background:white">Applications nonresponsive to terms of this NOSI will not be considered for the NOSI initiative.</span></p>
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<a name="_"></a><h2 class="heading2">Inquiries</h2>
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Please direct all inquiries to the contacts in Section VII of the listed funding opportunity announcements with the following additions/substitutions:
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<p class="Normal" style="margin: 1em 0in 6pt;"><b>Scientific/Research Contact(s) </b></p>
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<p class="Normal" style="margin: 0in 0in 6pt;"><normal class="Normal">Raul Mandler, MD<normal endtag="true"><normal class="Normal"><br />
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NIDA/DTMC/CMB<normal endtag="true"><normal class="Normal"><br />
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Telephone: 301-480-2541<normal endtag="true"><normal class="Normal"><br />
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Email: <a href="/cdn-cgi/l/email-protection#99f4f8f7fdf5fcebebd9f7f0f1b7fef6ef"><span class="__cf_email__" data-cfemail="335e525d575f564141735d5a5b1d545c45">[email protected]</span></a></span><normal endtag="true"></normal></normal></normal></normal></normal></normal></normal></normal></p>
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<A HREF="/grants/guide/WeeklyIndex.cfm?02-05-21">Weekly TOC for this Announcement</A><br>
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<A HREF="/grants/guide/index.html">NIH Funding Opportunities and Notices</A>
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