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<meta name="description" content="Based on very limited information, a single dose of dipyrone 500 mg provides good pain relief to about 70% of people treated, compared to about 30% with placebo. For every five people given dipyrone 500 mg, two people would experience this level of pain relief over four to six hours who would not ha …"><meta name="keywords" content="pmid:27096578, PMC6540653, doi:10.1002/14651858.CD011421.pub2, Meta-Analysis, Research Support, Non-U.S. Gov&#x27;t, Review, Systematic Review, Leslie Hearn, Sheena Derry, R Andrew Moore, Acute Pain / drug therapy*, Administration, Oral, Adult, Anti-Inflammatory Agents, Non-Steroidal / administration &amp; dosage*, Dipyrone / administration &amp; dosage*, Female, Humans, Injections, Intramuscular, Male, Pain, Postoperative / drug therapy*, Randomized Controlled Trials as Topic, PubMed Abstract, NIH, NLM, NCBI, National Institutes of Health, National Center for Biotechnology Information, National Library of Medicine, MEDLINE"><meta name="robots" content="index,nofollow,noarchive"><meta property="og:title" content="Single dose dipyrone (metamizole) for acute postoperative pain in adults - PubMed"><meta property="og:url" content="https://pubmed.ncbi.nlm.nih.gov/27096578/"><meta property="og:description" content="Based on very limited information, a single dose of dipyrone 500 mg provides good pain relief to about 70% of people treated, compared to about 30% with placebo. For every five people given dipyrone 500 mg, two people would experience this level of pain relief over four to six hours who would not ha …"><meta property="og:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:image:secure_url" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:type" content="website"><meta property="og:site_name" content="PubMed"><meta name="twitter:domain" content="pubmed.ncbi.nlm.nih.gov"><meta name="twitter:card" content="summary_large_image"><meta name="twitter:title" content="Single dose dipyrone (metamizole) for acute postoperative pain in adults - PubMed"><meta name="twitter:url" content="https://pubmed.ncbi.nlm.nih.gov/27096578/"><meta name="twitter:description" content="Based on very limited information, a single dose of dipyrone 500 mg provides good pain relief to about 70% of people treated, compared to about 30% with placebo. For every five people given dipyrone 500 mg, two people would experience this level of pain relief over four to six hours who would not ha …"><meta name="twitter:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg">
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<label for="email-citation-format" class="action-panel-label">
Format:
</label>
<select id="email-citation-format" name="citation-format" class="action-panel-selector email-citation-format">
<option selected="selected" value="summary">Summary</option>
<option value="summary-text">Summary (text)</option>
<option value="abstract">Abstract</option>
<option value="abstract-text">Abstract (text)</option>
</select>
</div>
<div class="include-supplemental-container">
<input type="checkbox" aria-label="Include MeSH and other data" name="include-supplemental" id="email-include-supplemental" class="email-include-supplemental">
<label for="email-include-supplemental" class="email-include-supplemental-label">MeSH and other data</label>
</div>
<div class="form-field recaptcha ">
<div class="g-recaptcha" id="id-recaptcha" data-sitekey="6LfsWHMdAAAAAClKbtOpjQ2pMjgsGxvv7NdZW9uI"></div>
</div>
<div id="captcha-error-message" class="usa-input-error-message captcha-validation-message" role="alert"></div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Sending..."
data-ga-category="save_share"
data-ga-action="email"
data-ga-label="send">
Send email
</button>
<button class="action-panel-cancel"
aria-label="Close 'Email citations' panel"
ref="linksrc=close_email_panel"
aria-controls="email-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="email"
data-ga-label="cancel">
Cancel
</button>
</div>
<input type="hidden" name="email-search-details" value="" />
<input type="hidden" name="email-search-details-hash" value="0e42663a6c3bd85498fcb88798998fed7bfdc45d457db35281e41afe13cc0524" />
</form>
</div>
</div>
<div id="collections-action-panel"
class="collections-action-panel action-panel in-progress-dots-panel"
aria-hidden="true"
data-collections-open-panel-enabled="false"
data-collections-open-panel-url-hash="#open-collections-panel">
<div class="inner-wrap">
<h3 class="action-panel-heading">
Add to Collections
</h3>
<form id="collections-action-panel-form"
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
data-existing-collections-url="/list-existing-collections/"
data-add-to-existing-collection-url="/add-to-existing-collection/"
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
data-myncbi-max-collection-name-length="100"
data-add-to-collection-max-amount="1000"
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/">
<input type="hidden" name="csrfmiddlewaretoken" value="s4HzoS4MrqQs8pbbMn7unYI0P1JtOLgcJRrE1Ix811DW2Qh1pGKwR6eEn5rFHmOw">
<div class="choice-group" role="radiogroup">
<ul class="radio-group-items">
<li>
<input type="radio"
id="collections-action-panel-new"
class="collections-new"
name="collections"
value="new"
data-ga-category="save_share"
data-ga-action="collections"
data-ga-label="collections_radio_new">
<label for="collections-action-panel-new">Create a new collection</label>
</li>
<li>
<input type="radio"
id="collections-action-panel-existing"
class="collections-existing"
name="collections"
value="existing"
checked="true"
data-ga-category="save_share"
data-ga-action="collections"
data-ga-label="collections_radio_existing">
<label for="collections-action-panel-existing">Add to an existing collection</label>
</li>
</ul>
</div>
<div class="controls-wrapper">
<div class="action-panel-control-wrap new-collections-controls">
<label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk">
Name your collection:
</label>
<input
type="text"
name="add-to-new-collection"
id="collections-action-panel-add-to-new"
class="collections-action-add-to-new"
pattern="[^&quot;&amp;=&lt;&gt;\/]*" title="The following characters are not allowed in the Name field: &quot;&amp;=&lt;&gt;/"
maxlength="100"
data-ga-category="save_share"
data-ga-action="create_collection"
data-ga-label="non_favorties_collection">
<div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
Name must be less than 100 characters
</div>
</div>
<div class="action-panel-control-wrap existing-collections-controls">
<label for="collections-action-panel-add-to-existing" class="action-panel-label">
Choose a collection:
</label>
<select id="collections-action-panel-add-to-existing"
class="action-panel-selector collections-action-add-to-existing"
data-ga-category="save_share"
data-ga-action="select_collection"
data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'">
</select>
<div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
Unable to load your collection due to an error<br>
<a href="#">Please try again</a>
</div>
</div>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Adding..."
data-pinger-ignore
data-ga-category="save_share"
data-ga-action="collections"
data-ga-label="add">
Add
</button>
<button class="action-panel-cancel"
aria-label="Close 'Add to Collections' panel"
ref="linksrc=close_collections_panel"
aria-controls="collections-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="collections"
data-ga-label="cancel">
Cancel
</button>
</div>
</form>
</div>
</div>
<div id="bibliography-action-panel"
class="bibliography-action-panel action-panel in-progress-dots-panel"
aria-hidden="true"
data-bibliography-open-panel-enabled="false"
data-bibliography-open-panel-url-hash="#open-bibliography-panel">
<div class="inner-wrap">
<h3 class="action-panel-heading">
Add to My Bibliography
</h3>
<form id="bibliography-action-panel-form"
class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
data-add-to-bibliography-max-amount="100"
data-add-to-bibliography-batch-size="10"
data-bibliography-delegates-url="/list-bibliography-delegates/"
data-add-to-bibliography-url="/add-to-bibliography/"
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/">
<input type="hidden" name="csrfmiddlewaretoken" value="s4HzoS4MrqQs8pbbMn7unYI0P1JtOLgcJRrE1Ix811DW2Qh1pGKwR6eEn5rFHmOw">
<div class="action-panel-control-wrap bibliographies-controls">
<div class="choice-group">
<ul class="bibliographies-action-add radio-group-items">
<li>
<input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/>
<label for="my-bibliography">My Bibliography</label>
</li>
</ul>
</div>
</div>
<div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message">
Unable to load your delegates due to an error<br>
<a href="#">Please try again</a>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Adding..."
data-pinger-ignore>
Add
</button>
<button class="action-panel-cancel"
aria-label="Close 'Add to bibliography' panel"
ref="linksrc=close_bibliography_panel"
aria-controls="bibliography-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="mybib"
data-ga-label="cancel">
Cancel
</button>
</div>
</form>
</div>
</div>
<div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true"
data-saved-search-open-panel-enabled="false"
data-saved-search-open-panel-url-hash="#open-saved-search-panel">
<div class="inner-wrap">
<h2 class="action-panel-heading">
Your saved search
</h2>
<form id="saved-search-action-panel-form"
class="saved-search-action-panel-form action-panel-content action-form"
data-create-saved-search-url="/create-saved-search/"
data-try-search-terms-url="/try-search-term/"
data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/">
<input type="hidden" name="csrfmiddlewaretoken" value="s4HzoS4MrqQs8pbbMn7unYI0P1JtOLgcJRrE1Ix811DW2Qh1pGKwR6eEn5rFHmOw">
<div class="action-panel-control-wrap">
<label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk">
Name of saved search:
</label>
<input maxlength="200"
type="text"
name="saved-search-name"
id="saved-search-name"
class="saved-search-name"
value=""
required
pattern="[^&quot;&amp;=&lt;&gt;\/]*" title="The following characters are not allowed in the Name field: &quot;&amp;=&lt;&gt;/">
</div>
<div class="action-panel-control-wrap">
<label for="saved-search-term" class="action-panel-label required-field-asterisk">
Search terms:
</label>
<textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea>
</div>
<div class="test-search-term-wrap">
<a href="#" class="try-search-term">Test search terms</a>
</div>
<div class="choice-group action-panel-extra-margin-top">
<span class="action-panel-label" id="fieldset-label">
Would you like email updates of new search results?
</span>
<fieldset id="saved-search-alert" aria-describedby="fieldset-label">
<legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend>
<ul class="radio-group-items">
<li>
<input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked>
<label for="saved-search-alert-yes" class="action-panel-label">Yes</label>
</li>
<li>
<input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no">
<label for="saved-search-alert-no" class="action-panel-label">No</label>
</li>
</ul>
</fieldset>
</div>
<div class="alert-schedule-wrap">
<div class="action-panel-control-wrap">
<label class="action-panel-label">
Email:
</label>
<span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span>
</div>
<div class="action-panel-control-wrap action-panel-extra-margin-top">
<label for="saved-search-frequency" class="action-panel-label">
Frequency:
</label>
<select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency">
<option value="monthly">Monthly</option>
<option value="weekly">Weekly</option>
<option value="daily">Daily</option>
</select>
</div>
<div class="action-panel-control-wrap saved-search-monthly-additional">
<label for="saved-search-monthly-on-day" class="action-panel-label">
Which day?
</label>
<select id="saved-search-monthly-on-day" class="no-border-panel-selector">
<option value="Sunday">The first Sunday</option>
<option value="Monday">The first Monday</option>
<option value="Tuesday">The first Tuesday</option>
<option value="Wednesday">The first Wednesday</option>
<option value="Thursday">The first Thursday</option>
<option value="Friday">The first Friday</option>
<option value="Saturday">The first Saturday</option>
<option value="day">The first day</option>
<option value="weekday">The first weekday</option>
</select>
</div>
<div class="action-panel-control-wrap saved-search-weekly-additional">
<label for="saved-search-weekly-on-day" class="action-panel-label">
Which day?
</label>
<select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day">
<option value="Sunday">Sunday</option>
<option value="Monday">Monday</option>
<option value="Tuesday">Tuesday</option>
<option value="Wednesday">Wednesday</option>
<option value="Thursday">Thursday</option>
<option value="Friday">Friday</option>
<option value="Saturday">Saturday</option>
</select>
</div>
<div class="action-panel-control-wrap">
<label for="saved-search-report" class="action-panel-label">
Report format:
</label>
<select id="saved-search-report" class="no-border-panel-selector saved-search-report">
<option value="DocSum">Summary</option>
<option value="DocSumText">Summary (text)</option>
<option value="Abstract">Abstract</option>
<option value="AbstractText">Abstract (text)</option>
<option value="MEDLINE">PubMed</option>
</select>
</div>
<div class="action-panel-control-wrap">
<label for="saved-search-amount" class="action-panel-label">
Send at most:
</label>
<select id="saved-search-amount" class="no-border-panel-selector saved-search-amount">
<option value="1">1 item</option>
<option value="5" selected>5 items</option>
<option value="10">10 items</option>
<option value="20">20 items</option>
<option value="50">50 items</option>
<option value="100">100 items</option>
<option value="200">200 items</option>
</select>
</div>
<div>
<input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result">
<label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox">
Send even when there aren't any new results
</label>
</div>
<div class="action-panel-control-wrap option-text-in-email-wrap">
<label for="saved-search-email-text" class="action-panel-label">
Optional text in email:
</label>
<textarea name="saved-search-email-text"
id="saved-search-email-text"
class="saved-search-email-text"></textarea>
</div>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Saving..."
data-ga-category="save_share"
data-ga-action="alert"
data-ga-label="save">
Save
</button>
<button class="action-panel-cancel"
aria-label="Close 'Your saved search' panel"
ref="linksrc=close_saved_search_panel"
aria-controls="saved-search-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="alert"
data-ga-label="cancel">
Cancel
</button>
</div>
</form>
</div>
</div>
<div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true">
<div class="inner-wrap">
<h2 class="action-panel-heading">
Create a file for external citation management software
</h2>
<form id="citation-manager-action-panel-form"
class="action-panel-content action-form"
action="/results-export-ids/"
data-by-search-action="/results-export-search-data/"
data-by-ids-action="/results-export-ids/"
method="post"
data-by-search-method="post"
data-by-ids-method="post">
<input type="hidden" name="csrfmiddlewaretoken" value="s4HzoS4MrqQs8pbbMn7unYI0P1JtOLgcJRrE1Ix811DW2Qh1pGKwR6eEn5rFHmOw">
<input name="results-format" type="hidden" value="pubmed"/>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Sending..."
data-ga-category="save_share"
data-ga-action="citation_manager"
data-ga-label="save">
Create file
</button>
<button class="action-panel-cancel"
aria-label="Close 'Send citations to citation manager' panel"
ref="linksrc=close_citation_manager_panel"
aria-controls="citation-manager-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="citation_manager"
data-ga-label="cancel">
Cancel
</button>
</div>
</form>
</div>
</div>
<div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true">
<div class="inner-wrap">
<h2 class="action-panel-heading">
Your RSS Feed
</h2>
<form id="rss-action-panel-form"
class="rss-action-panel-form action-panel-content action-form"
data-create-rss-feed-url="/create-rss-feed-url/"
data-search-form-term-value="">
<input type="hidden" name="csrfmiddlewaretoken" value="s4HzoS4MrqQs8pbbMn7unYI0P1JtOLgcJRrE1Ix811DW2Qh1pGKwR6eEn5rFHmOw">
<div class="action-panel-control-wrap">
<label for="rss-name" class="action-panel-label required-field-asterisk">
Name of RSS Feed:
</label>
<input maxlength="200"
placeholder="Name"
type="text"
name="rss-name"
id="rss-name"
class="rss-name"
value=''
required
pattern="[^&quot;&amp;=&lt;&gt;\/]*" title="The following characters are not allowed in the Name field: &quot;&amp;=&lt;&gt;/">
</div>
<div class="rss-limit-wrap">
<div class="action-panel-control-wrap action-panel-extra-margin-top">
<label for="rss-limit" class="action-panel-label">
Number of items displayed:
</label>
<select id="rss-limit" class="no-border-panel-selector rss-limit">
<option value="5">5</option>
<option value="10">10</option>
<option value="15" selected="selected">15</option>
<option value="20">20</option>
<option value="50">50</option>
<option value="100">100</option>
</select>
</div>
</div>
<div class="action-panel-actions">
<button class="action-panel-submit"
type="submit"
data-loading-label="Creating..."
data-ga-category="save_share"
data-ga-action="alert"
data-ga-label="save">
Create RSS
</button>
<button class="action-panel-cancel"
aria-label="Close 'Your RSS' panel"
ref="linksrc=close_rss_panel"
aria-controls="rss-action-panel"
aria-expanded="false"
data-ga-category="save_share"
data-ga-action="alert"
data-ga-label="cancel">
Cancel
</button>
</div>
<div class="action-panel-control-wrap rss-link-copy-wrap">
<label for="rss-link" class="usa-sr-only">RSS Link</label>
<input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link">
<button
type="button"
disabled
class="rss-link-copy-button disabled"
data-ga-category="save_share"
data-ga-action="rss"
data-ga-label="copy">
Copy
</button>
</div>
</form>
</div>
</div>
</div>
</div>
<div class="article-page" id="article-page" data-article-pmid="27096578">
<aside class="page-sidebar">
<div class="inner-wrap">
<div class="full-text-links">
<div class="full-view">
<h3 class="title">
Full text links
</h3>
<div class="full-text-links-list">
<a class="link-item
dialog-focus"
href="https://doi.org/10.1002/14651858.CD011421.pub2"
target="_blank"
rel="noopener"
ref="linksrc=fulltextorjournal_fulltext&amp;is_pmc=False&amp;PrId=3058&amp;itool=Abstract-def&amp;log$=linkouticon&amp;uid=27096578&amp;db=pubmed&amp;nlmid=100909747"
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Wiley
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pmc
"
href="https://pmc.ncbi.nlm.nih.gov/articles/pmid/27096578/"
target="_blank"
rel="noopener"
ref="linksrc=fulltextorjournal_fulltext&amp;is_pmc=True&amp;PrId=3494&amp;itool=Abstract-def&amp;log$=linkouticon&amp;uid=27096578&amp;db=pubmed&amp;nlmid=100909747"
title="Free full text at PubMed Central"
data-ga-category="full_text"
data-ga-action="PMC"
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Free PMC article
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</div>
<div class="short-view">
<a href="#" class="full-text-links-button full-text-links-dialog-trigger">
Full text links
</a>
</div>
</div>
<div class="actions-buttons sidebar"><h3 class="title">Actions</h3><div class="inner-wrap"><button class="citation-button citation-dialog-trigger"
aria-label="Open dialog with citation text in different styles"
data-ga-category="save_share"
data-ga-action="cite"
data-ga-label="open"
data-all-citations-url="/27096578/citations/"
data-citation-style="nlm"
data-pubmed-format-link="/27096578/export/"><span class="button-label">Cite</span></button><link type="text/css" href="ncbi-overlay-block/src/overlay-block.css"><div class="collections-button-container" data-article-id="27096578" data-article-db="pubmed"><button class="collections-button collections-dialog-trigger"
aria-label="Save article in MyNCBI collections."
data-ga-category="collections_button"
data-ga-action="click"
data-ga-label="collections_button"
data-collections-open-dialog-enabled="false"
data-collections-open-dialog-url="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F27096578%2F%23open-collections-dialog"
data-in-collections="false"><span class="button-label">Collections</span></button><div class="overlay" role="dialog"><div id="collections-action-dialog"
class="dialog collections-dialog"
aria-hidden="true"><div class="title">Add to Collections</div><div class="collections-action-panel action-panel"><form id="collections-action-dialog-form"
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
data-existing-collections-url="/list-existing-collections/"
data-add-to-existing-collection-url="/add-to-existing-collection/"
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
data-myncbi-max-collection-name-length="100"
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="s4HzoS4MrqQs8pbbMn7unYI0P1JtOLgcJRrE1Ix811DW2Qh1pGKwR6eEn5rFHmOw"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio"
id="collections-action-dialog-new"
class="collections-new"
name="collections"
value="new"
data-ga-category="collections_button"
data-ga-action="click"
data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio"
id="collections-action-dialog-existing"
class="collections-existing"
name="collections"
value="existing"
checked="true"
data-ga-category="collections_button"
data-ga-action="click"
data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk">
Name your collection:
</label><input
type="text"
name="add-to-new-collection"
id="collections-action-dialog-add-to-new"
class="collections-action-add-to-new"
pattern="[^&quot;&amp;=&lt;&gt;\/]*" title="The following characters are not allowed in the Name field: &quot;&amp;=&lt;&gt;/"
maxlength="100"
data-ga-category="collections_button"
data-ga-action="create_collection"
data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
Name must be less than 100 characters
</div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label">
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Single dose dipyrone (metamizole) for acute postoperative pain in adults
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Background:
</strong>
Dipyrone (metamizole) is a nonsteroidal anti-inflammatory drug used in some countries to treat pain (postoperative, colic, cancer, and migraine); it is banned in other countries because of an association with life-threatening blood disorders. This review replaces a 2010 Cochrane review that has been withdrawn.
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To assess the analgesic efficacy and associated adverse events of single dose dipyrone for moderate to severe acute postoperative pain using methods that permit comparison with other analgesics evaluated in standardised trials using almost identical methods and outcomes.
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We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, and LILACS to 11 August 2015; the Oxford Pain Relief Database; two clinical trial registries; and the reference lists of articles.
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We included randomised, double-blind, placebo-controlled trials of single dose dipyrone for relief of established moderate to severe postoperative pain in adults. We accepted oral, rectal, intramuscular, and intravenous routes of administration.
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</strong>
Two review authors independently considered studies for inclusion in the review, assessed risk of bias, and extracted data. We used summed total pain relief or pain intensity difference (TOTPAR or SPID) over four to six hours to calculate the number of participants achieving at least 50% pain relief. From derived results, we calculated the risk ratio and number needed to treat for an additional beneficial outcome (NNT), with 95% confidence intervals (CI), for one participant to experience at least 50% pain relief over four to six hours compared to placebo. We looked at use of rescue medication and time to use of rescue medication as additional measures of efficacy. We also looked for information on adverse events and withdrawals.
</p>
<p>
<strong class="sub-title">
Main results:
</strong>
We included eight studies, involving 809 participants, comparing oral dipyrone 500 mg (143 participants), oral dipyrone 1000 mg (57 participants), and intramuscular dipyrone 2000 mg (35 participants) with placebo (236 participants). In addition to placebo, all studies used active controls (ibuprofen, paracetamol, aspirin, flurbiprofen, ketoprofen; 338 participants). Seven studies used the oral route of administration, and one study used the intramuscular route. The mean age ranged from 23 to 62 years. Six studies included both men and women, and two studies included only women. All the studies were small, but were otherwise of moderate to good quality.Over 70% of participants experienced our primary outcome of at least 50% pain relief over four to six hours with oral dipyrone 500 mg compared to 30% with placebo (five studies, 288 participants; NNT 2.4 (95% CI 1.8 to 3.1)) (moderate quality evidence). There were insufficient data to assess other doses or routes of administration of dipyrone.Fewer participants needed rescue medication within four to six hours with dipyrone 500 mg than with placebo (7% with dipyrone versus 34% with placebo; four studies, 248 participants) (low quality evidence).The data on numbers of participants experiencing any adverse event was inconsistently reported and no analysis was possible. No serious adverse events or adverse event withdrawals were reported (very low quality evidence).There were too few data to compare dipyrone directly with other active treatments.
</p>
<p>
<strong class="sub-title">
Authors&#x27; conclusions:
</strong>
Based on very limited information, a single dose of dipyrone 500 mg provides good pain relief to about 70% of people treated, compared to about 30% with placebo. For every five people given dipyrone 500 mg, two people would experience this level of pain relief over four to six hours who would not have done with placebo, and fewer people would need rescue medication.We were unable to compare dipyrone directly with other active treatments, or to assess the effects of different doses or routes of administration, or the number of participants experiencing adverse events, because of insufficient data and inadequate reporting.
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Conflict of interest statement
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<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">LH none known</p>
<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">SD none known</p>
<p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">RAM has received institutional grant support from RB relating to individual patient level analyses of trial data on ibuprofen in acute pain and the effects of food on drug absorption of analgesics (2013), and from Grünenthal relating to individual patient level analyses of trial data regarding tapentadol in osteoarthritis and back pain (2015). He has attended boards with Menarini concerning methods of analgesic trial design (2014), with Novartis (2014) about the design of network metaanalyses, and RB on understanding pharmacokinetics of drug uptake (2015).</p>
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<div class="figure-caption-contents"><p> Study flow diagram. </p></div>
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<div class="figure-caption-contents"><p> Risk of bias graph: review authors'… </p></div>
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<p> 2 </p>
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<div class="figure-caption-contents"><p> Risk of bias graph: review authors' judgements about each risk of bias item presented… </p></div>
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<div class="figure-caption-contents">Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.</div>
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<div class="figure-caption-contents">Risk of bias summary: review authors' judgements about each risk of bias item for each included study.</div>
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<p> 4 </p>
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<div class="figure-caption-contents"><p> Forest plot of comparison: 1 Oral… </p></div>
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<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
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<p> 4 </p>
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<div class="figure-caption-contents"><p> Forest plot of comparison: 1 Oral dipyrone 500 mg versus placebo, outcome: 1.1 Participants… </p></div>
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<div class="figure-caption-contents">Forest plot of comparison: 1 Oral dipyrone 500 mg versus placebo, outcome: 1.1 Participants with ≥ 50% pain relief over 4 to 6 hours.</div>
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</strong>
<div class="figure-caption-contents"><p> Comparison 1 Oral dipyrone 500… </p></div>
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<p> 1.1. Analysis </p>
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<div class="figure-caption-contents"><p> Comparison 1 Oral dipyrone 500 mg versus placebo, Outcome 1 Participants with ≥… </p></div>
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</strong>
<div class="figure-caption-contents">Comparison 1 Oral dipyrone 500 mg versus placebo, Outcome 1 Participants with ≥ 50% pain relief over 4 to 6 hours.</div>
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<div class="references" id="references">
<h2 class="title">
References
</h2>
<div id='top-references-list' class="references-lists-container">
<div class="refs-list">
<h4 class="refs-list-title">References to studies included in this review</h4>
<div class="refs-list">
<h5 class="refs-list-title">Bhounsule 1990 {published data only}</h5>
<ol id="top-references-list-2" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Bhounsule SA, Nevreker PR, Agshikar NV, Pal MN, Dhume VG. A comparison of four analgesics in postepisiotomy pain. Indian Journal of Physiology and Pharmacology 1990;34(1):348.
-
<a
class="reference-link"
href="/2361721/"
ref="linksrc=references_link&amp;ordinalpos=1"
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PubMed
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</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Boraks 1987 {published data only}</h5>
<ol id="top-references-list-3" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Boraks S. Low dose flurbiprofen compared to dipyrone, acetylsalicylic acid and placebo in the treatment of postextraction dental pain [Flurbiprofen em dose baixa comparado a dipirona, acido acetilsalicilico e placebo no tratamento da dor posextracao dentaria]. Arquivos Brasileiros de Medicina 1987;61:42430.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">De Miguel Rivero 1997 {published data only}</h5>
<ol id="top-references-list-4" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Miguel Rivero C, Araujo CG, Sousa MM, Saenz López de Rueda F, Luna González F, Padilla Márquez A, et al. Comparative efficacy of oral ibuprofenarginine, intramuscular magnesic dipyrone and placebo in patients with postoperative pain following total hip replacement. Clinical Drug Investigation 1997;14(4):27685.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Dos Santos Pereira 1986 {published data only}</h5>
<ol id="top-references-list-5" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Dos Santos Pereira E. Comparative study of acetaminophen, dipyrone and placebo in the treatment of postoperative pain in orthopedics [Estudo comparativo entre acetaminofen, dipirona e placebo no tratamento da dor pósoperatória em ortopedia]. Folha Médica 1986;92(1/2):99105.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Olson 1999 {published data only}</h5>
<ol id="top-references-list-6" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Olson NZ, Sunshine A, Zighelboim I, Lange R. Analgesic efficacy of liquid ketoprofen compared to liquid dipyrone and placebo administered orally as drops in postepisiotomy pain. International Journal of Clinical Pharmacology and Therapeutics 1999;37(4):16874.
-
<a
class="reference-link"
href="/10235419/"
ref="linksrc=references_link&amp;ordinalpos=1"
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</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Pinto 1984 {published data only}</h5>
<ol id="top-references-list-7" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Pinto JA, Rosenberg PH, Heino A, Scheinin B. Evaluation of acetaminophen, dipyrone and placebo in the treatment of posttonsillectomy pain [Avaliacao de acetaminofen, dipirona e placebo no tratamento da dor posamigdalectomia]. Revista Brasileira de Cirurgia 1984;74(4):18590.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Rubinstein 1986 {published data only}</h5>
<ol id="top-references-list-8" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Rubinstein I, Canalini AF. Doubleblind study comparing acetaminophen, dipyrone and placebo on postoperative pain in urology [Estudo duplocego comparativo entre acetaminofen, dipirona e placebo na dor pósoperatória em urologia]. Folha Médica 1986;92:2016.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Sakata 1986 {published data only}</h5>
<ol id="top-references-list-9" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Sakata RK, Lauzi J, Kuniyoshi HS, Ono MT. Comparative doubleblind study with a single dose of acetaminophen, dipyrone and placebo in the treatment of postoperative pain. Revista Brasileira de Cirurgia 1986;76(5):3014.
</li>
</ol>
</li>
</ol>
</div>
</div>
<div class="refs-list">
<h4 class="refs-list-title">References to studies excluded from this review</h4>
<div class="refs-list">
<h5 class="refs-list-title">Aizawa 1972 {published data only}</h5>
<ol id="top-references-list-11" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Aizawa N, Mivagawa H, Kitamura M, Yamamoto T, Koide A. Effect of dpropoxyphene napsylate (S9700) on postoperative pain. Saishin Igaku. Modern Medicine 1972;27:7505.
-
<a
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href="/4554713/"
ref="linksrc=references_link&amp;ordinalpos=1"
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</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Bagan 1998 {published data only}</h5>
<ol id="top-references-list-12" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Bagan JV, Lopez Arranz JS, Valencia E, Santamaría J, Eguidazu I, Horas M, et al. Clinical comparison of dexketoprofen trometamol and dipyrone in postoperative dental pain. Journal of Clinical Pharmacology 1998;38 12 Suppl:55S64S.
-
<a
class="reference-link"
href="/9882083/"
ref="linksrc=references_link&amp;ordinalpos=1"
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</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Bosch 1990 {published data only}</h5>
<ol id="top-references-list-13" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Bosch F, Toranzo I, Banos JE. Dental pain as a model for studying selfmedication with analgesics. European Journal of Pharmacology 1990;183(3):10367.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Brodner 2011 {published data only}</h5>
<ol id="top-references-list-14" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Brodner G, Gogarten W, Aken H, Hahnenkamp K, Wempe C, Freise H, et al. Efficacy of intravenous paracetamol compared to dipyrone and parecoxib for postoperative pain management after minortointermediate surgery: a randomised, doubleblind trial. European Journal of Anaesthesiology 2011;28(2):12532. [DOI: 10.1097/EJA.0b013e32833fedfa]
-
<a
class="reference-link"
href="https://doi.org/10.1097/eja.0b013e32833fedfa"
ref="linksrc=references_link&amp;ordinalpos=1"
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data-ga-action="10.1097/EJA.0b013e32833fedfa"
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DOI
</a>
-
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PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Casali 1981 {published data only}</h5>
<ol id="top-references-list-15" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Casali R, Novelli GP, Bonetti L. A comparison of dipyrone with pethidine in postoperative pain. Anestesia e Rianimazione 1981;22:14354.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Castro 2000 {published data only}</h5>
<ol id="top-references-list-16" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Castro F, Pardo D, Mosquera G, Peleteiro R, Camba MA. Postoperative pain management with PCA in upper abdominal surgery: a comparative study, versus metamizol tramadol and ketorolac [Tratamiento del dolor postoperatorio con PCA en cirugía del abdomen superior: estudio comparativo, tramadol versus metamizol y ketorolaco]. Revista de la Sociedad Espanola del Dolor 2000;7:126.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Daftary 1980 {published data only}</h5>
<ol id="top-references-list-17" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Daftary SN, Mehta AC, Nanavati M. A controlled comparison of dipyrone and paracetamol in postepisiotomy pain. Current Medical Research and Opinion 1980;6(9):6148.
-
<a
class="reference-link"
href="/6996931/"
ref="linksrc=references_link&amp;ordinalpos=1"
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PubMed
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</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Ferrario 1984 {published data only}</h5>
<ol id="top-references-list-18" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Ferrario F, Frassineti L. IV ASA for postsurgical pain of the spine. European Review for Medical and Pharmacological Sciences 1984;6(1):14752.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Frantz 2009 {published data only}</h5>
<ol id="top-references-list-19" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Frantz KA, Moura Filho EdeR, Abud BM, Avila MP, Magacho L. Comparison of the analgesic effect between 90 mg etoricoxib and dipyrone after exeresis of primary pterygium with conjunctival autograft [Comparaçao do efeito analgesico entre etoricoxib 90 mg e dipirona sodica na exerese de pterigio primario com transplante autologo de conjuntiva]. Arquivos Brasileiros de Oftalmologia 2009;72(5):6614. [DOI: 10.1590/S0004-27492009000500012]
-
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class="reference-link"
href="https://doi.org/10.1590/s0004-27492009000500012"
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DOI
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-
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data-ga-action="20027405"
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PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Gomez Jimenez 1980 {published data only}</h5>
<ol id="top-references-list-20" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Gomez Jimenez J, Franco Patino R, Chargoy Vera J, Olivares Sosa R. Clinical efficacy of mild analgesics in pain following gynaecological or dental surgery: report on multicentre studies (Studies 1 &amp; 2). British Journal of Clinical Pharmacology 1980;10 Suppl 2:355S8S.
-
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class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC1430187/"
ref="linksrc=references_link&amp;ordinalpos=1"
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data-ga-action="PMC1430187"
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PMC
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-
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PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Gonzalez Garcia 1994 {published data only}</h5>
<ol id="top-references-list-21" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Gonzalez Garcia CA, Ibarra Ibarra LG, Barbosa Vivanco S. Comparative study of ketorolac and dipyrone administered orally in the treatment of postoperative pain. Proceedings of the Western Pharmacology Society 1994;37:1212.
-
<a
class="reference-link"
href="/7984640/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
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PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Goutaine 1975 {published data only}</h5>
<ol id="top-references-list-22" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Goutaine DJ. Valve of the use of an analgesic and antispasmodic medication in surgery. Semaine des hopitaux. Therapeutique 1975;51(1):158.
-
<a
class="reference-link"
href="/1162367/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="1162367"
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PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Hernandez 1997 {published data only}</h5>
<ol id="top-references-list-23" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Hernandez LG. Comparison of analgesia provided by dipyrone and diclofenac in postoperative patients of abdominal surgery [Comparacion de la analgesia proporcionada por diclofenaco y dipirona en pacientes posoperados de cirugia de abdomen]. Anestesia En Mexico 1997;9:13742.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Herrera Barroso 1982 {published data only}</h5>
<ol id="top-references-list-24" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Herrera Barroso M, Monroe P, Neuvonen PJ. Doubleblind evaluation of analgesic efficacy and tolerance of sodium and dipyrone zomepirac, a single dose in postoperative pain [Evaluacion doble ciego de la eficacia analgesica y tolerancia de zomepirac sodico y dipirona, a dosis unica en dolor posoperatorio]. Investigacion Medica Internacional 1982;9(2):16470.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">IbarraIbarra 1993 {published data only}</h5>
<ol id="top-references-list-25" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
IbarraIbarra LG, Cubillo MA, Silva Adaya A, Gonzalez Garcia CA. Comparative study of ketorolac and dipyrone in the treatment of postoperative pain. Proceedings of the Western Pharmacology Society 1993;36:1335.
-
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class="reference-link"
href="/8378366/"
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</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Lal 1973 {published data only}</h5>
<ol id="top-references-list-26" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Lal A, Pandey K, Chandra P, Pande SB. Dipyrone for treatment of postoperative pain. Anaesthesia 1973;28(1):437.
-
<a
class="reference-link"
href="/4346973/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="4346973"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Martin Duce 1997 {published data only}</h5>
<ol id="top-references-list-27" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Martin Duce A, Moreno J, Puerta J, Ortiz P. Effectiveness of metamizol in the management of pain after abdominal surgery: comparison of 1 or 2 g by the intramuscular or intravenous route. Pain Clinic 1997;10(1):2734.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Mehta 1967 {published data only}</h5>
<ol id="top-references-list-28" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Mehta S. Comparison of pethidine with sodium phenyldimethyl pyrazolone methylaminomethane sulphonate (novalgin) and placebo in postoperative pain. Indian Journal of Anaesthesia 1967;15:232.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Mendl 1992 {published data only}</h5>
<ol id="top-references-list-29" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Mendl G. Controlled clinical trials of dipyrone in postoperative pain conditions. Satellite symposium to the World Conference on Clinical Pharmacology and Therapeutics in Yokohama, Japan. World Conference on Clinical Pharmacology and Therapeutics, 1992.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Mukherjee 1980 {published data only}</h5>
<ol id="top-references-list-30" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Mukherjee S, Sood S. A controlled evaluation of orally administered aspirin, dipyrone and placebo in patients with postoperative pain. Current Medical Research and Opinion 1980;6(9):61923.
-
<a
class="reference-link"
href="/6996932/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="6996932"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Noronha 2009 {published data only}</h5>
<ol id="top-references-list-31" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Noronha VR, Gurgel GD, Alves LC, NomanFerreira LC, Mendonça LL, Aguiar EG, et al. Analgesic efficacy of lysine clonixinate, paracetamol and dipyrone in lower third molar extraction: a randomized controlled trial. Medicina oral, patología oral y cirugía bucal 2009;14(8):e4115.
-
<a
class="reference-link"
href="/19415056/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="19415056"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Patel 1980 {published data only}</h5>
<ol id="top-references-list-32" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Patel CV, Koppikar MG, Patel MS, Parulkar GB. A doubleblind comparison of parenteral dipyrone and pethidine in the treatment of postoperative pain. Current Medical Research and Opinion 1980;6(9):6249.
-
<a
class="reference-link"
href="/6996933/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="6996933"
>
PubMed
</a>
</li>
</ol>
</li>
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Patel CV, Koppikar MG, Patel MS, Parulkar GB, Pinto Pereira LM. A double blind comparison of parenteral analgin with pethidine. Journal of Postgraduate Medicine 1980;26(3):1626.
-
<a
class="reference-link"
href="/7009845/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="7009845"
>
PubMed
</a>
</li>
</ol>
</li>
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Patel CV, Koppikar MG, Patel MS, Parulkar GB, Pinto Pereira LM. Management of pain after abdominal surgery: dipyrone compared with pethidine. British Journal of Clinical Pharmacology 1980;10:351S4S.
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC1430171/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="PMC1430171"
>
PMC
</a>
-
<a
class="reference-link"
href="/7437276/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="7437276"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Quiñones 1993 {published data only}</h5>
<ol id="top-references-list-33" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Quiñones R, Oscar A. Comparative study of the efficacy of analgesic of the analgesic in the postoperative pain of general surgery [Estudio comparativo de la eficacia analgesica de la buprenorfina, clorhidrato de nalbufina, clohidrato de tramadol y dipirona en el manejo dl dolor postoperative de cirugia general y traumatologia]. Med Postgrad MayoAugusto 1993;9(2):1935.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Reyes 1988 {published data only}</h5>
<ol id="top-references-list-34" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Reyes F. Randomized comparative doubleblind study between sodium diclofenac and sodium dipyrone in post operative pain [Estudio doble ciego randomizado comparativo entre diclofenaco sódico y dipirona sódica en dolor postquirúrgico]. Compendium de Investigaciones Clínicas Latinoamericanas 1988;8:6573.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Rosas Pérez 1986 {published data only}</h5>
<ol id="top-references-list-35" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Rosas Pérez O, Salinas FA. Rating analgesic efficacy and tolerability of Suprofen and dipyrone in patients with episiotomy pain [Valoración del efecto analgésico y tolerabilidad de suprofén y dipirona en pracientes con dolor debido a episiotomía]. Investigacion Médica Internacional 1986;13:1058.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Saray 2001 {published data only}</h5>
<ol id="top-references-list-36" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Saray A, Büyükkocak U, Cinel I, Tellioglu AT, Oral U. Diclofenac and metamizol in postoperative analgesia in plastic surgery. Acta Chirurgiae Plasticae 2001;43(3):716.
-
<a
class="reference-link"
href="/11692987/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="11692987"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Sener 2008 {published data only}</h5>
<ol id="top-references-list-37" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Sener M, Yilmazer C, Yilmaz I, Bozdogan N, Ozer C, Donmez A, et al. Efficacy of lornoxicam for acute postoperative pain relief after septoplasty: a comparison with diclofenac, ketoprofen, and dipyrone. Journal of Clinical Anesthesia 2008;20(2):1038. [DOI: 10.1016/j.jclinane.2007.09.009]
-
<a
class="reference-link"
href="https://doi.org/10.1016/j.jclinane.2007.09.009"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/j.jclinane.2007.09.009"
>
DOI
</a>
-
<a
class="reference-link"
href="/18410864/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="18410864"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Stankov 1995 {published data only}</h5>
<ol id="top-references-list-38" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Stankov G, Schmieder G, Lechner FJ, Schinzel S. Observerblind multicentre study with dipyrone versus tramadol in postoperative pain. European Journal of Pain 1995;16(12):5663.
</li>
</ol>
</li>
</ol>
</div>
</div>
<div class="refs-list">
<h4 class="refs-list-title">Additional references</h4>
<div class="refs-list">
<h5 class="refs-list-title">Andersohn 2007</h5>
<ol id="top-references-list-40" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Andersohn F, Konzen C, Garbe E. Systematic review: agranulocytosis induced by nonchemotherapy drugs. Annals of Internal Medicine 2007;146:65765. [DOI: 10.7326/0003-4819-146-9-200705010-00009]
-
<a
class="reference-link"
href="https://doi.org/10.7326/0003-4819-146-9-200705010-00009"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.7326/0003-4819-146-9-200705010-00009"
>
DOI
</a>
-
<a
class="reference-link"
href="/17470834/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="17470834"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Andrade 1998</h5>
<ol id="top-references-list-41" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Andrade SE, Martinez C, Walker AM. Comparative safety evaluation of nonnarcotic analgesics. Journal of Clinical Epidemiology 1998;51(12):135765. [DOI: 10.1016/S0895-4356(98)00076-6]
-
<a
class="reference-link"
href="https://doi.org/10.1016/s0895-4356(98)00076-6"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/S0895-4356(98)00076-6"
>
DOI
</a>
-
<a
class="reference-link"
href="/10086830/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="10086830"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Arellano 1990</h5>
<ol id="top-references-list-42" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Arellano F, Sacristán JA. Metamizole: reassessment of its therapeutic role. European Journal of Clinical Pharmacology 1990;38(6):6179. [DOI: 10.1007/BF00278592]
-
<a
class="reference-link"
href="https://doi.org/10.1007/bf00278592"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1007/BF00278592"
>
DOI
</a>
-
<a
class="reference-link"
href="/2197099/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="2197099"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Barden 2004</h5>
<ol id="top-references-list-43" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Barden J, Edwards JE, McQuay HJ, Moore RA. Pain and analgesic response after third molar extraction and other postsurgical pain. Pain 2004;107(12):8690. [DOI: 10.1016/j.pain.2003.09.021]
-
<a
class="reference-link"
href="https://doi.org/10.1016/j.pain.2003.09.021"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/j.pain.2003.09.021"
>
DOI
</a>
-
<a
class="reference-link"
href="/14715393/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="14715393"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Bonkowsky 2002</h5>
<ol id="top-references-list-44" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Bonkowsky JL, Frazer JK, Buchi KF, Byington CL. Metamizole use by Latino immigrants: a common and potentially harmful home remedy. Pediatrics 2002;109(6):e98. [DOI: 10.1542/peds.109.6.e98]
-
<a
class="reference-link"
href="https://doi.org/10.1542/peds.109.6.e98"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1542/peds.109.6.e98"
>
DOI
</a>
-
<a
class="reference-link"
href="/12042592/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="12042592"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Collins 1997</h5>
<ol id="top-references-list-45" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Collins SL, Moore RA, McQuay HJ. The visual analogue pain intensity scale: what is moderate pain in millimetres?. Pain 1997;72:957. [DOI: 10.1016/S0304-3959(97)00005-5]
-
<a
class="reference-link"
href="https://doi.org/10.1016/s0304-3959(97)00005-5"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/S0304-3959(97)00005-5"
>
DOI
</a>
-
<a
class="reference-link"
href="/9272792/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="9272792"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Collins 2001</h5>
<ol id="top-references-list-46" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Collins SL, Edwards J, Moore RA, Smith LA, McQuay HJ. Seeking a simple measure of analgesia for megatrials: is a single global assessment good enough?. Pain 2001;91(12):18994. [DOI: 10.1016/S0304-3959(00)00435-8]
-
<a
class="reference-link"
href="https://doi.org/10.1016/s0304-3959(00)00435-8"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/S0304-3959(00)00435-8"
>
DOI
</a>
-
<a
class="reference-link"
href="/11240091/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="11240091"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Cook 1995</h5>
<ol id="top-references-list-47" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Cook RJ, Sackett DL. The number needed to treat: a clinically useful measure of treatment effect. BMJ 1995;310:4524. [DOI: 10.1136/bmj.310.6977.452]
-
<a
class="reference-link"
href="https://doi.org/10.1136/bmj.310.6977.452"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1136/bmj.310.6977.452"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2548824/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC2548824"
>
PMC
</a>
-
<a
class="reference-link"
href="/7873954/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="7873954"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Cooper 1991</h5>
<ol id="top-references-list-48" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Cooper SA. Singledose analgesic studies: the upside and downside of assay sensitivity. In: Max MB, Portenoy RK, Laska EM editor(s). The Design of Analgesic Clinical Trials. Advances in Pain Research and Therapy. Vol. 18, New York: Raven Press, 1991:11724.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Dechartres 2013</h5>
<ol id="top-references-list-49" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Dechartres A, Trinquart L, Boutron I, Ravaud P. Influence of trial sample size on treatment effect estimates: metaepidemiological study. BMJ 2013;346:f2304. [DOI: 10.1136/bmj.f2304]
-
<a
class="reference-link"
href="https://doi.org/10.1136/bmj.f2304"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1136/bmj.f2304"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC3634626/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC3634626"
>
PMC
</a>
-
<a
class="reference-link"
href="/23616031/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="23616031"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Edwards 2002</h5>
<ol id="top-references-list-50" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Edwards JE, McQuay HJ. Dipyrone and agranulocytosis: what is the risk?. Lancet 2002;360(9344):1438. [DOI: 10.1016/S0140-6736(02)11489-9]
-
<a
class="reference-link"
href="https://doi.org/10.1016/s0140-6736(02)11489-9"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/S0140-6736(02)11489-9"
>
DOI
</a>
-
<a
class="reference-link"
href="/12433507/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="12433507"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">FitzGerald 2001</h5>
<ol id="top-references-list-51" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
FitzGerald GA, Patrono C. The coxibs, selective inhibitors of cyclooxygenase2. New England Journal of Medicine 2001;345(6):43342. [DOI: 10.1056/NEJM200108093450607]
-
<a
class="reference-link"
href="https://doi.org/10.1056/nejm200108093450607"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1056/NEJM200108093450607"
>
DOI
</a>
-
<a
class="reference-link"
href="/11496855/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="11496855"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">GRADEpro GDT 2016 [Computer program]</h5>
<ol id="top-references-list-52" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
McMaster University (developed by Evidence Prime, Inc.). GRADEpro Guideline Development Tool [Software]. Available from <a class="external-link-urlize" href="http://www.gradepro.org" rel="nofollow noopener" target="_blank">www.gradepro.org</a> (accessed 3 March 2016). McMaster University (developed by Evidence Prime, Inc.), 2016.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Hawkey 1999</h5>
<ol id="top-references-list-53" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Hawkey CJ. Cox2 inhibitors. Lancet 1999;353(9149):30714. [DOI: 10.1016/S0140-6736(98)12154-2]
-
<a
class="reference-link"
href="https://doi.org/10.1016/s0140-6736(98)12154-2"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/S0140-6736(98)12154-2"
>
DOI
</a>
-
<a
class="reference-link"
href="/9929039/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="9929039"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Hawkey 2002</h5>
<ol id="top-references-list-54" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Hawkey C. Cyclooxygenase inhibition: between the devil and the deep blue sea. Gut 2002;50 Suppl 3:iii25iii30. [DOI: 10.1136/gut.50.suppl_3.iii25]
-
<a
class="reference-link"
href="https://doi.org/10.1136/gut.50.suppl_3.iii25"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1136/gut.50.suppl_3.iii25"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC1867681/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC1867681"
>
PMC
</a>
-
<a
class="reference-link"
href="/11953329/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="11953329"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Hedenmalm 2002</h5>
<ol id="top-references-list-55" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Hedenmalm K, Spigset O. Agranulocytosis and other blood dyscrasias associated with dipyrone (metamizole). European Journal of Clinical Pharmacology 2002;58:26574. [DOI: 10.1007/s00228-002-0465-2]
-
<a
class="reference-link"
href="https://doi.org/10.1007/s00228-002-0465-2"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1007/s00228-002-0465-2"
>
DOI
</a>
-
<a
class="reference-link"
href="/12136373/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="12136373"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Higgins 2011</h5>
<ol id="top-references-list-56" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane<a class="external-link-urlize" href="http://handbook.org" rel="nofollow noopener" target="_blank">handbook.org</a>.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Huber 2014</h5>
<ol id="top-references-list-57" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Huber M, Andersohn F, Bronder E, Klimpel A, Thomae M, Konzen C, et al. Druginduced agranulocytosis in the Berlin casecontrol surveillance study. European Journal of Clinical Pharmacology 2014;70(3):33945. [DOI: 10.1007/s00228-013-1618-1]
-
<a
class="reference-link"
href="https://doi.org/10.1007/s00228-013-1618-1"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1007/s00228-013-1618-1"
>
DOI
</a>
-
<a
class="reference-link"
href="/24297345/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="24297345"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">IAAAS 1986</h5>
<ol id="top-references-list-58" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
The International Agranulocytosis and Aplastic Anemia Study. Risks of agranulocytosis and aplastic anemia a first report of their relation to drug use with special reference to analgesics. JAMA 1986;256(13):174957. [DOI: 10.1001/jama.1986.03380130077032]
-
<a
class="reference-link"
href="https://doi.org/10.1001/jama.1986.03380130077032"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1001/jama.1986.03380130077032"
>
DOI
</a>
-
<a
class="reference-link"
href="/3747087/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="3747087"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Ibáñez 2005</h5>
<ol id="top-references-list-59" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Ibáñez L, Vidal X, Ballarín E, Laporte JR. Agranulocytosis associated with dipyrone (metamizol). European Journal of Clinical Pharmacology 2005;60:8219. [DOI: 10.1007/s00228-004-0836-y]
-
<a
class="reference-link"
href="https://doi.org/10.1007/s00228-004-0836-y"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1007/s00228-004-0836-y"
>
DOI
</a>
-
<a
class="reference-link"
href="/15580488/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="15580488"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Jadad 1996a</h5>
<ol id="top-references-list-60" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Jadad AR, Carroll D, Moore A, McQuay H. Developing a database of published reports of randomised clinical trials in pain research. Pain 1996;66:23946. [DOI: 10.1016/0304-3959(96)03033-3]
-
<a
class="reference-link"
href="https://doi.org/10.1016/0304-3959(96)03033-3"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/0304-3959(96)03033-3"
>
DOI
</a>
-
<a
class="reference-link"
href="/8880846/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="8880846"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Jadad 1996b</h5>
<ol id="top-references-list-61" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Controlled Clinical Trials 1996;17:112. [DOI: 10.1016/0197-2456(95)00134-4]
-
<a
class="reference-link"
href="https://doi.org/10.1016/0197-2456(95)00134-4"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/0197-2456(95)00134-4"
>
DOI
</a>
-
<a
class="reference-link"
href="/8721797/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="8721797"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Jage 2008</h5>
<ol id="top-references-list-62" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Jage J, LaufenbergFeldmann R, Heid F. Drugs for postoperative analgesia: routine and new aspects. Part 1: nonopioids [Medikamente zur postoperativen Schmerztherapie: Bewahrtes und Neues. Teil 1: Nichtopioide]. Der Anaesthesist 2008;57(4):38290. [DOI: 10.1007/s00101-008-1326-x]
-
<a
class="reference-link"
href="https://doi.org/10.1007/s00101-008-1326-x"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1007/s00101-008-1326-x"
>
DOI
</a>
-
<a
class="reference-link"
href="/18351305/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="18351305"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Kramer 1988</h5>
<ol id="top-references-list-63" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Kramer MS. The International Agranulocytosis and Aplastic Anemia Study (IAAAS). Journal of Clinical Epidemiology 1988;41(6):6134. [DOI: 10.1016/0895-4356(88)90069-8]
-
<a
class="reference-link"
href="https://doi.org/10.1016/0895-4356(88)90069-8"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/0895-4356(88)90069-8"
>
DOI
</a>
-
<a
class="reference-link"
href="/3290398/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="3290398"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Kötter 2015</h5>
<ol id="top-references-list-64" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Kötter T, Costa BR, Fässler M, Blozik E, Linde K, Jüni P, et al. Metamizoleassociated adverse events: a systematic review and metaanalysis. PLoS One 2015;10(4):e0122918. [DOI: 10.1371/journal.pone.0122918]
-
<a
class="reference-link"
href="https://doi.org/10.1371/journal.pone.0122918"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1371/journal.pone.0122918"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4405027/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC4405027"
>
PMC
</a>
-
<a
class="reference-link"
href="/25875821/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="25875821"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">L'Abbé 1987</h5>
<ol id="top-references-list-65" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
L'Abbé KA, Detsky AS, O'Rourke K. Metaanalysis in clinical research. Annals of Internal Medicine 1987;107:22433. [DOI: 10.7326/0003-4819-107-2-224]
-
<a
class="reference-link"
href="https://doi.org/10.7326/0003-4819-107-2-224"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.7326/0003-4819-107-2-224"
>
DOI
</a>
-
<a
class="reference-link"
href="/3300460/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="3300460"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Laporte 1991</h5>
<ol id="top-references-list-66" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Laporte J, Carne X. Upper gastrointestinal bleeding in relation to previous use of analgesics and nonsteroidal antiinflammatory drugs. Lancet 1991;337(8733):859. [DOI: 10.1016/0140-6736(91)90744-A]
-
<a
class="reference-link"
href="https://doi.org/10.1016/0140-6736(91)90744-a"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/0140-6736(91)90744-A"
>
DOI
</a>
-
<a
class="reference-link"
href="/1670734/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="1670734"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Laporte 2004</h5>
<ol id="top-references-list-67" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Laporte JR, Ibáñez L, Vidal X, Vendrell L, Leone R. Upper gastrointestinal bleeding associated with the use of NSAIDs: newer versus older agents. Drug Safety 2004;27(6):41120. [PUBMED: 15144234]
-
<a
class="reference-link"
href="/15144234/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="15144234"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Lobo 2013</h5>
<ol id="top-references-list-68" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Lobo MG, Pinheiro SM, Castro JG, Momenté VG, Pranchevicius MC. Adverse drug reaction monitoring: support for pharmacovigilance at a tertiary care hospital in Northern Brazil. BMC Pharmacology &amp; Toxicology 2013;14:5. [DOI: 10.1186/2050-6511-14-5]
-
<a
class="reference-link"
href="https://doi.org/10.1186/2050-6511-14-5"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1186/2050-6511-14-5"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC3554560/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC3554560"
>
PMC
</a>
-
<a
class="reference-link"
href="/23298396/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="23298396"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">McQuay 2005</h5>
<ol id="top-references-list-69" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
McQuay HJ, Moore RA. Placebo. Postgraduate Medical Journal 2005;81:15560. [DOI: 10.1136/pgmj.2004.024737]
-
<a
class="reference-link"
href="https://doi.org/10.1136/pgmj.2004.024737"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1136/pgmj.2004.024737"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC1743225/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC1743225"
>
PMC
</a>
-
<a
class="reference-link"
href="/15749790/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="15749790"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Moore 1996</h5>
<ol id="top-references-list-70" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Moore A, McQuay H, Gavaghan D. Deriving dichotomous outcome measures from continuous data in randomised controlled trials of analgesics. Pain 1996;66(23):22937. [DOI: 10.1016/0304-3959(96)03032-1]
-
<a
class="reference-link"
href="https://doi.org/10.1016/0304-3959(96)03032-1"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/0304-3959(96)03032-1"
>
DOI
</a>
-
<a
class="reference-link"
href="/8880845/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="8880845"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Moore 1997a</h5>
<ol id="top-references-list-71" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Moore A, McQuay H, Gavaghan D. Deriving dichotomous outcome measures from continuous data in randomised controlled trials of analgesics: verification from independent data. Pain 1997;69(12):12730. [DOI: 10.1016/S0304-3959(96)03251-4]
-
<a
class="reference-link"
href="https://doi.org/10.1016/s0304-3959(96)03251-4"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/S0304-3959(96)03251-4"
>
DOI
</a>
-
<a
class="reference-link"
href="/9060022/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="9060022"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Moore 1997b</h5>
<ol id="top-references-list-72" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Moore A, Moore O, McQuay H, Gavaghan D. Deriving dichotomous outcome measures from continuous data in randomised controlled trials of analgesics: use of pain intensity and visual analogue scales. Pain 1997;69(3):3115. [DOI: 10.1016/S0304-3959(96)03306-4]
-
<a
class="reference-link"
href="https://doi.org/10.1016/s0304-3959(96)03306-4"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/S0304-3959(96)03306-4"
>
DOI
</a>
-
<a
class="reference-link"
href="/9085306/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="9085306"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Moore 1998</h5>
<ol id="top-references-list-73" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Moore RA, Gavaghan D, Tramer MR, Collins SL, McQuay HJ. Size is everything large amounts of information are needed to overcome random effects in estimating direction and magnitude of treatment effects. Pain 1998;78(3):20916. [DOI: 10.1016/S0304-3959(98)00140-7]
-
<a
class="reference-link"
href="https://doi.org/10.1016/s0304-3959(98)00140-7"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/S0304-3959(98)00140-7"
>
DOI
</a>
-
<a
class="reference-link"
href="/9870574/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="9870574"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Moore 2003</h5>
<ol id="top-references-list-74" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Moore RA, Edwards J, Barden J, McQuay HJ. Bandolier's Little Book of Pain. Oxford: Oxford University Press, 2003. [ISBN: 0192632477]
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Moore 2005</h5>
<ol id="top-references-list-75" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Moore RA, Edwards JE, McQuay HJ. Acute pain: individual patient metaanalysis shows the impact of different ways of analysing and presenting results. Pain 2005;116(3):32231. [DOI: 10.1016/j.pain.2005.05.001]
-
<a
class="reference-link"
href="https://doi.org/10.1016/j.pain.2005.05.001"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1016/j.pain.2005.05.001"
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</a>
-
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PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Moore 2006</h5>
<ol id="top-references-list-76" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Moore A, McQuay H. Bandolier's Little Book of Making Sense of the Medical Evidence. Oxford: Oxford University Press, 2006. [ISBN: 0198566042]
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Moore 2008</h5>
<ol id="top-references-list-77" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Moore RA, Barden J, Derry S, McQuay HJ. Managing potential publication bias. In: McQuay HJ, Kalso E, Moore RA editor(s). Systematic Reviews in Pain Research: Methodology Refined. Seattle: IASP Press, 2008:1523. [ISBN: 9780931092695]
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Moore 2015a</h5>
<ol id="top-references-list-78" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Moore RA, Derry S, Aldington D, Wiffen PJ. Single dose oral analgesics for acute postoperative pain in adults an overview of Cochrane reviews. Cochrane Database of Systematic Reviews 2015, Issue 9. [DOI: 10.1002/14651858.CD008659.pub3]
-
<a
class="reference-link"
href="https://doi.org/10.1002/14651858.cd008659.pub3"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1002/14651858.CD008659.pub3"
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DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6485441/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC6485441"
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PMC
</a>
-
<a
class="reference-link"
href="/26414123/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="26414123"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Moore 2015b</h5>
<ol id="top-references-list-79" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Moore RA, Derry S, Aldington D, Wiffen PJ. Adverse events associated with single dose oral analgesics for acute postoperative pain in adults an overview of Cochrane reviews. Cochrane Database of Systematic Reviews 2015, Issue 10. [DOI: 10.1002/14651858.CD011407.pub2]
-
<a
class="reference-link"
href="https://doi.org/10.1002/14651858.cd011407.pub2"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1002/14651858.CD011407.pub2"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6485338/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC6485338"
>
PMC
</a>
-
<a
class="reference-link"
href="/26461263/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="26461263"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Morris 1995</h5>
<ol id="top-references-list-80" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Morris JA, Gardner MJ. Calculating confidence intervals for relative risk, odds ratios and standardised ratios and rates. In: Gardner MJ, Altman DG editor(s). Statistics with Confidence Confidence Intervals and Statistical Guidelines. London: BMJ Books, 1995:5063.
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2545775/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="PMC2545775"
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PMC
</a>
-
<a
class="reference-link"
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ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="3133061"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Mérida Rodrigo 2009</h5>
<ol id="top-references-list-81" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Mérida Rodrigo L, Faus Felipe V, Poveda Gómez F, García Alegría J. Agranulocytosis from metamizole: a potential problem for the British population. Revista Clinica Espanola 2009;209(4):1769. [PUBMED: 19457324]
-
<a
class="reference-link"
href="/19457324/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="19457324"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Nikolova 2013</h5>
<ol id="top-references-list-82" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Nikolova I, Petkova V, Tencheva J, Benbasat N, Voinikov J, Danchev N. Metamizole: a review profile of a wellknown "forgotten" drug. Part II: clinical profile. Biotechnology and Biotechnological Equipment 2013;27(2):360519.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Nüesch 2010</h5>
<ol id="top-references-list-83" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Nüesch E, Trelle S, Reichenbach S, Rutjes AW, Tschannen B, Altman DG, et al. Small study effects in metaanalyses of osteoarthritis trials: metaepidemiological study. BMJ 2010;341:c3515. [DOI: 10.1136/bmj.c3515]
-
<a
class="reference-link"
href="https://doi.org/10.1136/bmj.c3515"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1136/bmj.c3515"
>
DOI
</a>
-
<a
class="reference-link"
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ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC2905513"
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PMC
</a>
-
<a
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>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">PaPaS 2012</h5>
<ol id="top-references-list-84" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
PaPaS author and referee guidance. <a class="external-link-urlize" href="http://papas.cochrane.org/papasdocuments" rel="nofollow noopener" target="_blank">http://papas.cochrane.org/papasdocuments</a> (accessed 23 March 2016).
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Patrono 2009</h5>
<ol id="top-references-list-85" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Patrono C, Baigent C. Lowdose aspirin, coxibs, and other NSAIDS: a clinical mosaic emerges. Molecular Interventions 2009;9(1):319. [DOI: 10.1124/mi.9.1.8]
-
<a
class="reference-link"
href="https://doi.org/10.1124/mi.9.1.8"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1124/mi.9.1.8"
>
DOI
</a>
-
<a
class="reference-link"
href="/19299662/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="19299662"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">RevMan 2014 [Computer program]</h5>
<ol id="top-references-list-86" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Tramèr 1997</h5>
<ol id="top-references-list-87" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Tramèr MR, Reynolds DJM, Moore RA, McQuay HJ. Impact of covert duplicate results on metaanalysis: a case study. BMJ 1997;315:6359. [DOI: 10.1136/bmj.315.7109.635]
-
<a
class="reference-link"
href="https://doi.org/10.1136/bmj.315.7109.635"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1136/bmj.315.7109.635"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2127450/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC2127450"
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PMC
</a>
-
<a
class="reference-link"
href="/9310564/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="9310564"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
<div class="refs-list">
<h5 class="refs-list-title">Zukowski 2009</h5>
<ol id="top-references-list-88" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Zukowski M, Kotfis K. Safety of metamizole and paracetamol for acute pain treatment. Anestezjologia Intensywna Terapia 2009;41(3):1705. [PUBMED: 19999607]
-
<a
class="reference-link"
href="/19999607/"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="19999607"
>
PubMed
</a>
</li>
</ol>
</li>
</ol>
</div>
</div>
<div class="refs-list">
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<div class="refs-list">
<h5 class="refs-list-title">Derry 2010</h5>
<ol id="top-references-list-90" class="references-list">
<li>
<ol class="references-and-notes-list">
<li
class="skip-numbering"
value="1">
Derry S, Faura C, Edwards J, McQuay HJ, Moore RA. Single dose dipyrone for acute postoperative pain. Cochrane Database of Systematic Reviews 2010, Issue 11. [DOI: 10.1002/14651858.CD003227.pub2]
-
<a
class="reference-link"
href="https://doi.org/10.1002/14651858.cd003227.pub2"
ref="linksrc=references_link&amp;ordinalpos=1"
data-ga-category="reference"
data-ga-action="10.1002/14651858.CD003227.pub2"
>
DOI
</a>
-
<a
class="reference-link"
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4160844/"
ref="linksrc=references_link&amp;ordinalpos=2"
data-ga-category="reference"
data-ga-action="PMC4160844"
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PMC
</a>
-
<a
class="reference-link"
href="/20824835/"
ref="linksrc=references_link&amp;ordinalpos=3"
data-ga-category="reference"
data-ga-action="20824835"
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PubMed
</a>
</li>
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</li>
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