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||
Clipboard <span class="amount-in-clipboard"></span>
|
||
</a>
|
||
</div>
|
||
|
||
<span class="search-input-link user-guide-link" role="navigation" aria-label="User guide">
|
||
<a href="/help/"
|
||
data-ga-category="featured_link"
|
||
data-ga-action="user_guide">
|
||
User Guide
|
||
</a>
|
||
</span>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</form>
|
||
|
||
|
||
<div id="article-page-header">
|
||
<div id="article-top-actions-bar" class="article-top-actions-bar">
|
||
<div class="inner-wrap">
|
||
<div class="actions-container">
|
||
<div class="return-to-search">
|
||
|
||
|
||
</div>
|
||
|
||
<div class="multiple-results-actions " role="region" aria-label="save, email, send to">
|
||
<button id="save-results-panel-trigger"
|
||
type="button"
|
||
class="save-results save-results-panel-trigger"
|
||
aria-expanded="false"
|
||
aria-controls="save-action-panel"
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="open">
|
||
Save
|
||
</button><button id="email-results-panel-trigger"
|
||
type="button"
|
||
class="email-results email-results-panel-trigger"
|
||
aria-expanded="false"
|
||
aria-controls="email-action-panel"
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="open">
|
||
Email
|
||
</button><div class="more-actions dropdown-block"><button id="more-actions-trigger"
|
||
type="button"
|
||
class="trigger more-actions-trigger"
|
||
ref="linksrc=show_moreactions_btn"
|
||
aria-label="Send to"
|
||
aria-controls="more-actions-dropdown">Send to</button><div id="more-actions-dropdown" class="dropdown dropdown-container" hidden><div class="content"><ul class="more-actions-links"><li><a class="clipboard-panel-trigger dropdown-block-link "
|
||
href="#"
|
||
role="button"
|
||
data-ga-category="save_share"
|
||
data-ga-action="clipboard"
|
||
data-ga-label="send">
|
||
Clipboard
|
||
</a></li><li><a role="button" class="dropdown-block-link bibliography-trigger-target" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F24462098%2F%23open-bibliography-panel">My Bibliography</a></li><li><a role="button" class="dropdown-block-link collections-trigger-target" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F24462098%2F%23open-collections-panel">Collections</a></li><li><a role="button" class="citation-manager-panel-trigger dropdown-block-link citation-manager-trigger-target" href="#">Citation manager</a></li></ul></div></div></div>
|
||
</div>
|
||
|
||
|
||
|
||
<div class="display-options" data-format-key="format"
|
||
data-default-format-value="abstract"
|
||
data-current-format-value="abstract" role="region">
|
||
<button
|
||
class="trigger usa-button"
|
||
title="Change format"
|
||
data-ga-category="display_options"
|
||
data-ga-action="display_options_dialog">
|
||
<span class="button-label">Display options</span>
|
||
</button>
|
||
|
||
<div class="dropdown" hidden>
|
||
<div class="title">
|
||
Display options
|
||
</div>
|
||
|
||
<div class="content">
|
||
|
||
<div class="format-container">
|
||
<span class="option-label">
|
||
Format
|
||
</span>
|
||
<select name="format" data-initial-value="abstract" aria-label="Display format" id="article-display-format">
|
||
<option value="abstract">Abstract</option>
|
||
|
||
<option value="pubmed">PubMed</option>
|
||
|
||
<option value="pmid">PMID</option>
|
||
|
||
</select>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="J07iQ3kLGr29c0wAbhM6Js0N50SNTp990NRntTN7g2PD6rCqOAp8dAwrD4AZM0Ht">
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="article-panels-container" class="article-panels-container">
|
||
<div id="save-action-panel" class="save-action-panel action-panel" aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Save citation to file
|
||
</h2>
|
||
<form id="save-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/results-export-ids/"
|
||
data-by-search-action="/results-export-search-data/"
|
||
data-by-ids-action="/results-export-ids/"
|
||
method="post"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="J07iQ3kLGr29c0wAbhM6Js0N50SNTp990NRntTN7g2PD6rCqOAp8dAwrD4AZM0Ht">
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="save-action-format" class="action-panel-label">
|
||
Format:
|
||
</label>
|
||
<select id="save-action-format" name="results-format" class="action-panel-selector">
|
||
<option value="summary-text">Summary (text)</option>
|
||
<option value="pubmed-text">PubMed</option>
|
||
<option value="pmid">PMID</option>
|
||
<option value="abstract">Abstract (text)</option>
|
||
<option value="csv">CSV</option>
|
||
</select>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Saving..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="save">
|
||
Create file
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Save citations to file' panel"
|
||
ref="linksrc=close_save_panel"
|
||
aria-controls="save-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="email-action-panel"
|
||
class="email-action-panel action-panel"
|
||
aria-hidden="true"
|
||
data-recaptcha-script-url="https://www.recaptcha.net/recaptcha/enterprise.js?render=explicit&onload=onloadCaptchaCallback"
|
||
data-recaptcha-enabled="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Email citation
|
||
</h2>
|
||
<form id="email-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/send-email/"
|
||
data-by-search-action="/results-export-email-by-search-data/"
|
||
data-by-ids-action="/send-email/"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post"
|
||
method="post"
|
||
>
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="J07iQ3kLGr29c0wAbhM6Js0N50SNTp990NRntTN7g2PD6rCqOAp8dAwrD4AZM0Ht">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<span class="action-panel-label">
|
||
Subject:
|
||
</span>
|
||
<span class="email-subject" id="email-subject" aria-label="Email subject">1 selected item: 24462098 - PubMed</span>
|
||
<input type="hidden" name="email-subject" value="1 selected item: 24462098"/>
|
||
<input type="hidden" name="email-subject-hash" value="7eded10a44e6dc0a20c2de03bc15a838985667c62d851fdd9c516e6d1238cbf3"/>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-to" class="action-panel-label required-field-asterisk">
|
||
To:
|
||
</label>
|
||
<input type="email" aria-label="Recipient Email Address" placeholder="email@example.com" id="email-to" class="email-to" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="100" required>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-from" class="action-panel-label">
|
||
From:
|
||
</label>
|
||
<input type="email" aria-label="Sender Email Address" placeholder="email@example.com" id="email-from" class="email-from" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="256">
|
||
</div>
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-citation-format" class="action-panel-label">
|
||
Format:
|
||
</label>
|
||
<select id="email-citation-format" name="citation-format" class="action-panel-selector email-citation-format">
|
||
<option selected="selected" value="summary">Summary</option>
|
||
<option value="summary-text">Summary (text)</option>
|
||
<option value="abstract">Abstract</option>
|
||
<option value="abstract-text">Abstract (text)</option>
|
||
|
||
</select>
|
||
</div>
|
||
<div class="include-supplemental-container">
|
||
<input type="checkbox" aria-label="Include MeSH and other data" name="include-supplemental" id="email-include-supplemental" class="email-include-supplemental">
|
||
<label for="email-include-supplemental" class="email-include-supplemental-label">MeSH and other data</label>
|
||
</div>
|
||
|
||
|
||
|
||
<div class="form-field recaptcha ">
|
||
|
||
|
||
|
||
<div class="g-recaptcha" id="id-recaptcha" data-sitekey="6LfsWHMdAAAAAClKbtOpjQ2pMjgsGxvv7NdZW9uI"></div>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div id="captcha-error-message" class="usa-input-error-message captcha-validation-message" role="alert"></div>
|
||
|
||
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Sending..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="send">
|
||
Send email
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Email citations' panel"
|
||
ref="linksrc=close_email_panel"
|
||
aria-controls="email-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
<input type="hidden" name="email-search-details" value="" />
|
||
<input type="hidden" name="email-search-details-hash" value="0e42663a6c3bd85498fcb88798998fed7bfdc45d457db35281e41afe13cc0524" />
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="collections-action-panel"
|
||
class="collections-action-panel action-panel in-progress-dots-panel"
|
||
aria-hidden="true"
|
||
data-collections-open-panel-enabled="false"
|
||
data-collections-open-panel-url-hash="#open-collections-panel">
|
||
<div class="inner-wrap">
|
||
<h3 class="action-panel-heading">
|
||
Add to Collections
|
||
</h3>
|
||
|
||
|
||
<form id="collections-action-panel-form"
|
||
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-existing-collections-url="/list-existing-collections/"
|
||
data-add-to-existing-collection-url="/add-to-existing-collection/"
|
||
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
|
||
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
|
||
data-myncbi-max-collection-name-length="100"
|
||
data-add-to-collection-max-amount="1000"
|
||
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="J07iQ3kLGr29c0wAbhM6Js0N50SNTp990NRntTN7g2PD6rCqOAp8dAwrD4AZM0Ht">
|
||
|
||
|
||
|
||
<div class="choice-group" role="radiogroup">
|
||
<ul class="radio-group-items">
|
||
<li>
|
||
<input type="radio"
|
||
id="collections-action-panel-new"
|
||
class="collections-new"
|
||
name="collections"
|
||
value="new"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="collections_radio_new">
|
||
<label for="collections-action-panel-new">Create a new collection</label>
|
||
</li>
|
||
<li>
|
||
<input type="radio"
|
||
id="collections-action-panel-existing"
|
||
class="collections-existing"
|
||
name="collections"
|
||
value="existing"
|
||
checked="true"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="collections_radio_existing">
|
||
<label for="collections-action-panel-existing">Add to an existing collection</label>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="controls-wrapper">
|
||
<div class="action-panel-control-wrap new-collections-controls">
|
||
<label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk">
|
||
Name your collection:
|
||
</label>
|
||
<input
|
||
type="text"
|
||
name="add-to-new-collection"
|
||
id="collections-action-panel-add-to-new"
|
||
class="collections-action-add-to-new"
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"
|
||
maxlength="100"
|
||
data-ga-category="save_share"
|
||
data-ga-action="create_collection"
|
||
data-ga-label="non_favorties_collection">
|
||
<div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
|
||
Name must be less than 100 characters
|
||
</div>
|
||
</div>
|
||
<div class="action-panel-control-wrap existing-collections-controls">
|
||
<label for="collections-action-panel-add-to-existing" class="action-panel-label">
|
||
Choose a collection:
|
||
</label>
|
||
<select id="collections-action-panel-add-to-existing"
|
||
class="action-panel-selector collections-action-add-to-existing"
|
||
data-ga-category="save_share"
|
||
data-ga-action="select_collection"
|
||
data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'">
|
||
</select>
|
||
<div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your collection due to an error<br>
|
||
<a href="#">Please try again</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="add">
|
||
Add
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Add to Collections' panel"
|
||
ref="linksrc=close_collections_panel"
|
||
aria-controls="collections-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="bibliography-action-panel"
|
||
class="bibliography-action-panel action-panel in-progress-dots-panel"
|
||
aria-hidden="true"
|
||
data-bibliography-open-panel-enabled="false"
|
||
data-bibliography-open-panel-url-hash="#open-bibliography-panel">
|
||
<div class="inner-wrap">
|
||
<h3 class="action-panel-heading">
|
||
Add to My Bibliography
|
||
</h3>
|
||
<form id="bibliography-action-panel-form"
|
||
class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-add-to-bibliography-max-amount="100"
|
||
data-add-to-bibliography-batch-size="10"
|
||
data-bibliography-delegates-url="/list-bibliography-delegates/"
|
||
data-add-to-bibliography-url="/add-to-bibliography/"
|
||
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
|
||
data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="J07iQ3kLGr29c0wAbhM6Js0N50SNTp990NRntTN7g2PD6rCqOAp8dAwrD4AZM0Ht">
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap bibliographies-controls">
|
||
<div class="choice-group">
|
||
<ul class="bibliographies-action-add radio-group-items">
|
||
<li>
|
||
<input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/>
|
||
<label for="my-bibliography">My Bibliography</label>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your delegates due to an error<br>
|
||
<a href="#">Please try again</a>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore>
|
||
Add
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Add to bibliography' panel"
|
||
ref="linksrc=close_bibliography_panel"
|
||
aria-controls="bibliography-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="mybib"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true"
|
||
data-saved-search-open-panel-enabled="false"
|
||
data-saved-search-open-panel-url-hash="#open-saved-search-panel">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Your saved search
|
||
</h2>
|
||
|
||
<form id="saved-search-action-panel-form"
|
||
class="saved-search-action-panel-form action-panel-content action-form"
|
||
data-create-saved-search-url="/create-saved-search/"
|
||
data-try-search-terms-url="/try-search-term/"
|
||
data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="J07iQ3kLGr29c0wAbhM6Js0N50SNTp990NRntTN7g2PD6rCqOAp8dAwrD4AZM0Ht">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk">
|
||
Name of saved search:
|
||
</label>
|
||
<input maxlength="200"
|
||
type="text"
|
||
name="saved-search-name"
|
||
id="saved-search-name"
|
||
class="saved-search-name"
|
||
value=""
|
||
required
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/">
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-term" class="action-panel-label required-field-asterisk">
|
||
Search terms:
|
||
</label>
|
||
<textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea>
|
||
</div>
|
||
<div class="test-search-term-wrap">
|
||
<a href="#" class="try-search-term">Test search terms</a>
|
||
</div>
|
||
<div class="choice-group action-panel-extra-margin-top">
|
||
<span class="action-panel-label" id="fieldset-label">
|
||
Would you like email updates of new search results?
|
||
</span>
|
||
<fieldset id="saved-search-alert" aria-describedby="fieldset-label">
|
||
<legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend>
|
||
<ul class="radio-group-items">
|
||
<li>
|
||
<input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked>
|
||
<label for="saved-search-alert-yes" class="action-panel-label">Yes</label>
|
||
</li>
|
||
<li>
|
||
<input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no">
|
||
<label for="saved-search-alert-no" class="action-panel-label">No</label>
|
||
</li>
|
||
</ul>
|
||
</fieldset>
|
||
</div>
|
||
|
||
<div class="alert-schedule-wrap">
|
||
<div class="action-panel-control-wrap">
|
||
<label class="action-panel-label">
|
||
Email:
|
||
</label>
|
||
<span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span>
|
||
</div>
|
||
<div class="action-panel-control-wrap action-panel-extra-margin-top">
|
||
<label for="saved-search-frequency" class="action-panel-label">
|
||
Frequency:
|
||
</label>
|
||
<select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency">
|
||
<option value="monthly">Monthly</option>
|
||
<option value="weekly">Weekly</option>
|
||
<option value="daily">Daily</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap saved-search-monthly-additional">
|
||
<label for="saved-search-monthly-on-day" class="action-panel-label">
|
||
Which day?
|
||
</label>
|
||
<select id="saved-search-monthly-on-day" class="no-border-panel-selector">
|
||
<option value="Sunday">The first Sunday</option>
|
||
<option value="Monday">The first Monday</option>
|
||
<option value="Tuesday">The first Tuesday</option>
|
||
<option value="Wednesday">The first Wednesday</option>
|
||
<option value="Thursday">The first Thursday</option>
|
||
<option value="Friday">The first Friday</option>
|
||
<option value="Saturday">The first Saturday</option>
|
||
<option value="day">The first day</option>
|
||
<option value="weekday">The first weekday</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap saved-search-weekly-additional">
|
||
<label for="saved-search-weekly-on-day" class="action-panel-label">
|
||
Which day?
|
||
</label>
|
||
<select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day">
|
||
<option value="Sunday">Sunday</option>
|
||
<option value="Monday">Monday</option>
|
||
<option value="Tuesday">Tuesday</option>
|
||
<option value="Wednesday">Wednesday</option>
|
||
<option value="Thursday">Thursday</option>
|
||
<option value="Friday">Friday</option>
|
||
<option value="Saturday">Saturday</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-report" class="action-panel-label">
|
||
Report format:
|
||
</label>
|
||
<select id="saved-search-report" class="no-border-panel-selector saved-search-report">
|
||
<option value="DocSum">Summary</option>
|
||
<option value="DocSumText">Summary (text)</option>
|
||
<option value="Abstract">Abstract</option>
|
||
<option value="AbstractText">Abstract (text)</option>
|
||
<option value="MEDLINE">PubMed</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-amount" class="action-panel-label">
|
||
Send at most:
|
||
</label>
|
||
<select id="saved-search-amount" class="no-border-panel-selector saved-search-amount">
|
||
<option value="1">1 item</option>
|
||
<option value="5" selected>5 items</option>
|
||
<option value="10">10 items</option>
|
||
<option value="20">20 items</option>
|
||
<option value="50">50 items</option>
|
||
<option value="100">100 items</option>
|
||
<option value="200">200 items</option>
|
||
</select>
|
||
</div>
|
||
<div>
|
||
<input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result">
|
||
<label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox">
|
||
Send even when there aren't any new results
|
||
</label>
|
||
</div>
|
||
<div class="action-panel-control-wrap option-text-in-email-wrap">
|
||
<label for="saved-search-email-text" class="action-panel-label">
|
||
Optional text in email:
|
||
</label>
|
||
<textarea name="saved-search-email-text"
|
||
id="saved-search-email-text"
|
||
class="saved-search-email-text"></textarea>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Saving..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="save">
|
||
Save
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Your saved search' panel"
|
||
ref="linksrc=close_saved_search_panel"
|
||
aria-controls="saved-search-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Create a file for external citation management software
|
||
</h2>
|
||
<form id="citation-manager-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/results-export-ids/"
|
||
data-by-search-action="/results-export-search-data/"
|
||
data-by-ids-action="/results-export-ids/"
|
||
method="post"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="J07iQ3kLGr29c0wAbhM6Js0N50SNTp990NRntTN7g2PD6rCqOAp8dAwrD4AZM0Ht">
|
||
|
||
|
||
|
||
<input name="results-format" type="hidden" value="pubmed"/>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Sending..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="citation_manager"
|
||
data-ga-label="save">
|
||
Create file
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Send citations to citation manager' panel"
|
||
ref="linksrc=close_citation_manager_panel"
|
||
aria-controls="citation-manager-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="citation_manager"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Your RSS Feed
|
||
</h2>
|
||
|
||
<form id="rss-action-panel-form"
|
||
class="rss-action-panel-form action-panel-content action-form"
|
||
data-create-rss-feed-url="/create-rss-feed-url/"
|
||
data-search-form-term-value="">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="J07iQ3kLGr29c0wAbhM6Js0N50SNTp990NRntTN7g2PD6rCqOAp8dAwrD4AZM0Ht">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="rss-name" class="action-panel-label required-field-asterisk">
|
||
Name of RSS Feed:
|
||
</label>
|
||
<input maxlength="200"
|
||
placeholder="Name"
|
||
type="text"
|
||
name="rss-name"
|
||
id="rss-name"
|
||
class="rss-name"
|
||
value=''
|
||
required
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/">
|
||
</div>
|
||
|
||
<div class="rss-limit-wrap">
|
||
<div class="action-panel-control-wrap action-panel-extra-margin-top">
|
||
<label for="rss-limit" class="action-panel-label">
|
||
Number of items displayed:
|
||
</label>
|
||
<select id="rss-limit" class="no-border-panel-selector rss-limit">
|
||
<option value="5">5</option>
|
||
<option value="10">10</option>
|
||
<option value="15" selected="selected">15</option>
|
||
<option value="20">20</option>
|
||
<option value="50">50</option>
|
||
<option value="100">100</option>
|
||
</select>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Creating..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="save">
|
||
Create RSS
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Your RSS' panel"
|
||
ref="linksrc=close_rss_panel"
|
||
aria-controls="rss-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap rss-link-copy-wrap">
|
||
<label for="rss-link" class="usa-sr-only">RSS Link</label>
|
||
<input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link">
|
||
<button
|
||
type="button"
|
||
disabled
|
||
class="rss-link-copy-button disabled"
|
||
data-ga-category="save_share"
|
||
data-ga-action="rss"
|
||
data-ga-label="copy">
|
||
Copy
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="article-page" id="article-page" data-article-pmid="24462098">
|
||
<aside class="page-sidebar">
|
||
<div class="inner-wrap">
|
||
|
||
<div class="full-text-links">
|
||
<div class="full-view">
|
||
<h3 class="title">
|
||
Full text links
|
||
</h3>
|
||
<div class="full-text-links-list">
|
||
<a class="link-item
|
||
|
||
dialog-focus"
|
||
href="https://linkinghub.elsevier.com/retrieve/pii/S0896-6273(13)01132-X"
|
||
target="_blank"
|
||
rel="noopener"
|
||
|
||
ref="linksrc=fulltextorjournal_fulltext&is_pmc=False&PrId=3048&itool=Abstract-def&log$=linkouticon&uid=24462098&db=pubmed&nlmid=8809320"
|
||
title="See full text options at Elsevier Science"
|
||
|
||
data-ga-category="full_text"
|
||
data-ga-action="Elsevier Science"
|
||
data-ga-label="24462098"
|
||
><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--linkinghub.elsevier.com-ihub-images-celloa.png" alt="Elsevier Science full text link"><span class="text">
|
||
|
||
Elsevier Science
|
||
|
||
</span></a><a class="link-item
|
||
pmc
|
||
"
|
||
href="https://pmc.ncbi.nlm.nih.gov/articles/pmid/24462098/"
|
||
target="_blank"
|
||
rel="noopener"
|
||
|
||
ref="linksrc=fulltextorjournal_fulltext&is_pmc=True&PrId=3494&itool=Abstract-def&log$=linkouticon&uid=24462098&db=pubmed&nlmid=8809320"
|
||
title="Free full text at PubMed Central"
|
||
|
||
data-ga-category="full_text"
|
||
data-ga-action="PMC"
|
||
data-ga-label="24462098"
|
||
><span class="text">
|
||
|
||
Free PMC article
|
||
|
||
</span></a>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="short-view">
|
||
<a href="#" class="full-text-links-button full-text-links-dialog-trigger">
|
||
Full text links
|
||
</a>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div class="actions-buttons sidebar"><h3 class="title">Actions</h3><div class="inner-wrap"><button class="citation-button citation-dialog-trigger"
|
||
aria-label="Open dialog with citation text in different styles"
|
||
data-ga-category="save_share"
|
||
data-ga-action="cite"
|
||
data-ga-label="open"
|
||
data-all-citations-url="/24462098/citations/"
|
||
data-citation-style="nlm"
|
||
data-pubmed-format-link="/24462098/export/"><span class="button-label">Cite</span></button><link type="text/css" href="ncbi-overlay-block/src/overlay-block.css"><div class="collections-button-container" data-article-id="24462098" data-article-db="pubmed"><button class="collections-button collections-dialog-trigger"
|
||
aria-label="Save article in MyNCBI collections."
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_button"
|
||
data-collections-open-dialog-enabled="false"
|
||
data-collections-open-dialog-url="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F24462098%2F%23open-collections-dialog"
|
||
data-in-collections="false"><span class="button-label">Collections</span></button><div class="overlay" role="dialog"><div id="collections-action-dialog"
|
||
class="dialog collections-dialog"
|
||
aria-hidden="true"><div class="title">Add to Collections</div><div class="collections-action-panel action-panel"><form id="collections-action-dialog-form"
|
||
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-existing-collections-url="/list-existing-collections/"
|
||
data-add-to-existing-collection-url="/add-to-existing-collection/"
|
||
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
|
||
data-myncbi-max-collection-name-length="100"
|
||
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="J07iQ3kLGr29c0wAbhM6Js0N50SNTp990NRntTN7g2PD6rCqOAp8dAwrD4AZM0Ht"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio"
|
||
id="collections-action-dialog-new"
|
||
class="collections-new"
|
||
name="collections"
|
||
value="new"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio"
|
||
id="collections-action-dialog-existing"
|
||
class="collections-existing"
|
||
name="collections"
|
||
value="existing"
|
||
checked="true"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk">
|
||
Name your collection:
|
||
</label><input
|
||
type="text"
|
||
name="add-to-new-collection"
|
||
id="collections-action-dialog-add-to-new"
|
||
class="collections-action-add-to-new"
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"
|
||
maxlength="100"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="create_collection"
|
||
data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
|
||
Name must be less than 100 characters
|
||
</div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label">
|
||
Choose a collection:
|
||
</label><select id="collections-action-dialog-add-to-existing"
|
||
class="action-panel-selector collections-action-add-to-existing"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="select_collection"
|
||
data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="add">
|
||
Add
|
||
</button><button class="action-panel-cancel"
|
||
aria-label="Close 'Add to Collections' panel"
|
||
ref="linksrc=close_collections_panel"
|
||
aria-controls="collections-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger"
|
||
title="Open dialog with more actions to take"
|
||
ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format"
|
||
data-default-format-value="abstract"
|
||
data-current-format-value="abstract" role="region"><button
|
||
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Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice
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Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice
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Although protein-misfolding-mediated neurodegenerative diseases have been linked to aging, how aging contributes to selective neurodegeneration remains unclear. We established spinocerebellar ataxia 17 (SCA17) knockin mice that inducibly express one copy of mutant TATA box binding protein (TBP) at different ages by tamoxifen-mediated Cre recombination. We find that more mutant TBP accumulates in older mouse and that this accumulation correlates with age-related decreases in Hsc70 and chaperone activity. Consistently, older SCA17 mice experienced earlier neurological symptom onset and more severe Purkinje cell degeneration. Mutant TBP shows decreased association with XBP1s, resulting in the reduced transcription of mesencephalic astrocyte-derived neurotrophic factor (MANF), which is enriched in Purkinje cells. Expression of Hsc70 improves the TBP-XBP1s interaction and MANF transcription, and overexpression of MANF ameliorates mutant TBP-mediated Purkinje cell degeneration via protein kinase C (PKC)-dependent signaling. These findings suggest that the age-related decline in chaperone activity affects polyglutamine protein function that is important for the viability of specific types of neurons.
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src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa7e/4863472/336341db4e73/nihms781177f1.gif"
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alt="Figure 1" />
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<strong class="figure-label">
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<p> Figure 1. Characterization of TBP105Q Inducible KI… </p>
|
||
</strong>
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<strong class="figure-label">
|
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<p> Figure 1. Characterization of TBP105Q Inducible KI Mouse Model </p>
|
||
</strong>
|
||
|
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|
||
|
||
<div class="figure-caption-contents"><p> (A) A schematic illustration of expression… </p></div>
|
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<strong class="figure-label">
|
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Figure 1. Characterization of TBP105Q Inducible KI Mouse Model
|
||
</strong>
|
||
|
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|
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|
||
<div class="figure-caption-contents">(A) A schematic illustration of expression of mutant TBP in TBP105Q inducible KI mice. (B) Western blotting analys is of immunoprecipitated TBP from the cortex and liver of WT and TBP105Q inducible KI mice after tamoxifen induction for two months. The rabbit polyclonal antibody EM192 was used to immunoprecipitate TBP, and the mouse monoclonal antibody 1C2 was used to visualize mutant TBP (arrow). (C) Mutant TBP aggregates in the stacking gel were clearly detected in the cortex (Ctx), cerebellum (Cere), and muscle (Mus) of TBP105Q inducible KI mice by anti-TBP (1TBP18) but not in the kidney (Kid). (D) 1C2 immunohistochemical study confirming mutant TBP expression in the cerebellum, hippocampus, cortex, and striatum of 3- and 14-month-old KI mice injected with tamoxifen. Small aggregates of mutant TBP were visualized in the nucleus under 1003 magnification (arrows). Scale bars represent 100 µm(left) and 5 µm (right). (E) TBP105Q inducible KI and control mice at 3, 9, or 14 months of age were injected with tamoxifen in order to induce the expression of mutant TBP. The older KI mice showed earlier onset of body weight loss (day 35 for 14 months, p = 0.0374) than the younger KI mice (day 53 for 9 months, p = 0.0125, and day 113 for 3 months, p = 0.0438) after tamoxifen injection (n = 9–11 each group, two-way ANOVA, p < 0.0001). (F) The body weight of differently aged KI mice was also compared. (G) Representative images of differently aged (3, 9, and 14 months) KI mice (white arrow) were taken at the indicated days after tamoxifen injection.</div>
|
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href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa7e/4863472/4d9d1de09f32/nihms781177f2.jpg"
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itemprop="contentUrl"
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role="button"
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data-image-width="896"
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data-image-height="1050"
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data-image-alt="Figure 2"
|
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data-pmc-id="PMC4863472"
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||
data-figure-id="F2">
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<img class="figure-thumb" itemprop="thumbnail"
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id="article-image-1"
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src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa7e/4863472/ae4e19b8bee2/nihms781177f2.gif"
|
||
alt="Figure 2" />
|
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|
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|
||
<strong class="figure-label">
|
||
<p> Figure 2. Aging Exacerbates Neurological Phenotypes in… </p>
|
||
</strong>
|
||
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||
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|
||
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||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 2. Aging Exacerbates Neurological Phenotypes in TBP105Q Inducible KI Mouse Model </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> (A) Motor activity… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
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||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 2. Aging Exacerbates Neurological Phenotypes in TBP105Q Inducible KI Mouse Model
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">(A) Motor activity of mice injected with tamoxifen at 3, 9, and 14 months of age was analyzed by rotarod test. The older KI mice (day 9 for 14 months, p = 0.0031) showed earlier on set of motor impairment than the younger KI mice (day 15 for 9 months, p = 0.0298, and day 15 for 3 months, p = 0.0217) after tamoxifen injection (n = 9–11 each group, two-way ANOVA, p < 0.0001). (B) The rotarod performance of differently aged KI mice was also compared. (C) Motor coordination of mice was tested by balance beam walking assay 1.5 months after tamoxifen injection. The walking time of older TBP105Q inducible KI mice on the beam is significantly longer than that of young KI mice (n = 6; **p < 0.01). (D) Degeneration of Purkinje neurons labeled by anticalbindin in the cerebellum of KI mice injected with tamoxifen at different ages. WT mouse at 16 months of age served as a control. The scale bar represents 50 µm. (E) Quantification of Purkinje neuron number, molecular layer thickness, and dendritic branches in TBP105Q inducible KI mice at different ages (n = 6–8; *p < 0.05, **p < 0.01). (F and G) Western blotting (F) and quantitative analysis (G) of calbindin protein level in the cerebellum of 3-, 9-, and 14-month-old TBP105Q inducible KI mice. Actin was used as a loading control (*p < 0.05, **p < 0.01). Data are represented as mean ± SEM.</div>
|
||
|
||
|
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|
||
|
||
</figcaption>
|
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||
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data-slide-index="2"
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|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa7e/4863472/8760f9cffbc0/nihms781177f3.jpg"
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||
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data-image-width="936"
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|
||
data-image-alt="Figure 3"
|
||
data-pmc-id="PMC4863472"
|
||
data-figure-id="F3">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-2"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa7e/4863472/2887a0056df0/nihms781177f3.gif"
|
||
alt="Figure 3" />
|
||
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||
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|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 3. Age-Related Increase of Mutant TBP… </p>
|
||
</strong>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
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|
||
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|
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|
||
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|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 3. Age-Related Increase of Mutant TBP and Decrease of Wild-Type TBP in TBP105Q Inducible… </p>
|
||
</strong>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 3. Age-Related Increase of Mutant TBP and Decrease of Wild-Type TBP in TBP105Q Inducible KI Mice
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">(A) Western blotting analysis of soluble mutant TBP levels in the cortex and cerebellum of 3-, 9-, and 14-month old TBP105Q inducible KI mice. An age-related increase of soluble mutant TBP (arrow) was observed in KI mice. Control mice (Con) did not show mutant TBP expression. Actin was used as a loading control. (B) Quantification of the relative amount of TBP (the ratio of TBP to actin) on western blots (*p < 0.05). (C) RT-PCR revealed similar mRNA levels of mutant TBP in both the cortex and cerebellum of 3- and 9-month-old TBP105Q inducible KI mice. Actin was used as an internal control. (D) The ratio of mutant TBP to actin transcripts in RT-PCR is quantified. (E) Western blotting analysis of the expression of mouse endogenous WT TBP in the cerebellum of TBP105Q inducible KI and WT mice at 3, 9, and 14 months of age. (F) Quantitative analysis of WT TBP level on western blots by measurement of its ratio to actin (*p < 0.05, **p < 0.01). Data are represented as mean ± SEM.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
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|
||
<a class="figure-link"
|
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href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa7e/4863472/0d164bf02066/nihms781177f4.jpg"
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||
aria-describedby="figure-caption-3"
|
||
role="button"
|
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data-image-width="888"
|
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|
||
data-image-alt="Figure 4"
|
||
data-pmc-id="PMC4863472"
|
||
data-figure-id="F4">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-3"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa7e/4863472/a3b4bf4ad541/nihms781177f4.gif"
|
||
alt="Figure 4" />
|
||
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|
||
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||
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|
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||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 4. Age-Dependent Decrease in Chaperone Activity… </p>
|
||
</strong>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
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|
||
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|
||
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||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 4. Age-Dependent Decrease in Chaperone Activity and Hsc70 Level in Mouse Brain </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> (A) Western… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-3" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 4. Age-Dependent Decrease in Chaperone Activity and Hsc70 Level in Mouse Brain
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">(A) Western blotting analysis of p62 and LC3B level in the cortex and cerebellum of 3-, 12-, and 21-month-old WT mice. No significant difference was found among three age groups. (B) Luciferase protection assay was performed by incubating recombinant luciferase with lysates from either the cortex or cerebellum of 3-, 12-, and 21-month-old WT mice. Hsp inhibitor PU-H71 was added to the incubation in order to obtain Hsp-specific activity. (C) Decreased luciferase intensity was observed when brain lysates of 12- or 21-month-old mice were used, indicating an age-related decrease of chaperone activity in the cortex and cerebellum (*p < 0.05, **p < 0.01). (D) Western blot analysis of major chaperones with the cerebellum tissue from 3-, 12-, and 21-month-old WT mice. Actin was used as a loading control. (E) The relative levels of Hsp were normalized by actin for quantification. Hsc70 and Hsp90 showed a significant decrease with aging (*p < 0.05, **p < 0.01). (F) Hsc70 immunostaining showing age-dependent decrease in Hsc70 expression in Purkinje cells in WT mice at different ages (6, 18, and 24 months). Arrows indicate Purkinje cells. The scale bar represents 20 µm. Data are represented as mean ± SEM.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
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||
|
||
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|
||
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|
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|
||
<a class="figure-link"
|
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href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa7e/4863472/2f5a3f4145f3/nihms781177f5.jpg"
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data-image-alt="Figure 5"
|
||
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|
||
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|
||
<img class="figure-thumb" itemprop="thumbnail"
|
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id="article-image-4"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa7e/4863472/37aa25a35806/nihms781177f5.gif"
|
||
alt="Figure 5" />
|
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|
||
|
||
|
||
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||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 5. Decreased MANF Level in Purkinje… </p>
|
||
</strong>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
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|
||
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|
||
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||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Figure 5. Decreased MANF Level in Purkinje Neurons of TBP105Q Inducible KI Mice </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> (A) Western… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-4" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 5. Decreased MANF Level in Purkinje Neurons of TBP105Q Inducible KI Mice
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">(A) Western blotting analysis of MANF protein level in the cortex and cerebellum of 3-, 9-, and 14-month-old control and TBP105Q inducible KI mice. (B) Quantification of the ratio of MANF to actin showing that only the cerebellum in TBP105Q inducible KI mice, starting at 9 months, had a significant decrease of MANF in comparison to the control cerebellum (*p < 0.05, **p < 0.01). (C) Immunohistochemical study showing the enrichment of MANF in Purkinje neurons of WT cerebellum, and this enrichment is lost in the cerebellum of 14-month-old TBP105Q inducible KI mouse. Scale bars represent 40 µm. (D) RT-PCR revealed a decrease in MANF mRNA level, which is specific to the cerebellum of KI mice at an old age (9 months). Actin was used as an internal control. (E) Real-time PCR was used to confirm the RT-PCR result. Relative abundance of MANF was calculated with the value from the control mice set to 1, and actin served as an internal control (*p < 0.05). Data are represented as mean ± SEM.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
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|
||
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|
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|
||
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|
||
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|
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data-image-alt="Figure 6"
|
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|
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|
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<img class="figure-thumb" itemprop="thumbnail"
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|
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src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa7e/4863472/7ea66cbf2060/nihms781177f6.gif"
|
||
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|
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|
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|
||
<strong class="figure-label">
|
||
<p> Figure 6. Expanded polyQ Impairs the Binding… </p>
|
||
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|
||
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|
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|
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|
||
<strong class="figure-label">
|
||
<p> Figure 6. Expanded polyQ Impairs the Binding of TBP with XBP1s and Its Transcriptional Activity… </p>
|
||
</strong>
|
||
|
||
|
||
|
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|
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<figcaption id="figure-caption-5" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
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|
||
|
||
|
||
<strong class="figure-label">
|
||
Figure 6. Expanded polyQ Impairs the Binding of TBP with XBP1s and Its Transcriptional Activity for MANF Expression
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">(A) Western blotting analysis confirmed the expression of respective proteins (TBP13Q, TBP105Q, and XBP1s) in cells used for ChIP assay. (B) Semiquantitative PCR result using lysates from chromatin immunoprecipitation with anti-FLAG (ChIP, left). Control was beads only without anti-FLAG. More MANF promoter was pulled down in cells transfected with TBP13Q than with TBP105Q (right, **p < 0.01). (C) Coimmunoprecipitation of transfected XBP1s with TBP in the presence or absence of Hsc70. XBP1s was pulled down by XBP1 antibody in each sample, and less TBP105Q was pulled down with XBP1s. Overexpression of Hsc70 increased the precipitated amount of TBP (both 13Q and 105Q). (D) The relative amounts of TBP precipitated with XBP1s (*p < 0.05). (E) Schematic map of luciferase constructs for reporter assay. Luciferase activity of transfected HEK293 cells showed that XBP1s, but not XBP1u, greatly increased luciferase intensity. (F) Western blotting verifying the coexpression of TBP, Hsc70, and XBP1s with the MANF promoter reporter. (G) Overexpression of Hsc70 significantly rescued the impaired luciferase activity by TBP105Q (*p < 0.05). (H) Western blot analysis of MANF expression levels in TBP stably transfected cells that were transfected with (+) or without (−) HA-tagged Hsc70. The ratios of MANF to actin on the blot are also presented (*p < 0.05). Data are represented as mean ± SEM.</div>
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<p> Figure 7. Overexpression of MANF Ameliorates Toxicity… </p>
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<p> Figure 7. Overexpression of MANF Ameliorates Toxicity Caused by Mutant TBP In Vitro and In… </p>
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Figure 7. Overexpression of MANF Ameliorates Toxicity Caused by Mutant TBP In Vitro and In Vivo
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<div class="figure-caption-contents">(A) Schematic map of lentiviral MANF vector. (B) Western blotting analysis of HEK293 cells infected with lentiviral MANF for two days (Infected) confirming the expression of both MANF and ECFP. Uninfected HEK293 cells (Con) were used as a negative control. (C and D) PC12 cells stably expressing either WT TBP (TBP13Q) or mutant TBP (TBP105Q) were infected with lentiviral MANF or uninfected. Fluorescent imaging (C) and quantitative analysis (D; n = 15, **p < 0.01) showed that MANF significantly increased the percentage of cells with long neurites. The scale bar represents 10 µm. (E) Western blot analysis of PC12 cells stably expressing either WT TBP (TBP13Q) or mutant TBP (TBP105Q), which were infected with lentiviral MANF or GFP. (F) MTS assay showed a significant increase in the survival of PC12 cells (versus non-staurosporine-treated cells) expressing mutant TBP when infected with lentiviral MANF in comparison to lentiviral GFP (*p < 0.05, **p < 0.01). (G) One-year-old WT and TBP105Q inducible KI mice were injected with MANF lentivirus on the right side of the cerebellum and with lentiviral GFP on the left side. Fluorescence of GFP or ECFP was used to locate the region infected by lentivirus. Calbindin staining showed that MANF overexpression rescued the loss of Purkinje neurons caused by mutant TBP. The scale bar represents 50 µm. (H) Quantitative assessment of the number of Purkinje cells labeled by anticalbindin per image field (20×, n = 9, *p < 0.05). Data are represented as mean ± SEM.</div>
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<strong class="figure-label">
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<p> Figure 8. Expression of Transgenic MANF Ameliorates… </p>
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<strong class="figure-label">
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<p> Figure 8. Expression of Transgenic MANF Ameliorates Pathological Phenotypes of SCA17 KI Mice via PKC… </p>
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<strong class="figure-label">
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Figure 8. Expression of Transgenic MANF Ameliorates Pathological Phenotypes of SCA17 KI Mice via PKC Phosphorylation
|
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</strong>
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<div class="figure-caption-contents">(A) Schematic map of transgenic MANF construct. (B) Anti-HA western blotting verified the expression of transgenic MANF-HA in the brain cortex and cerebellum in MANF transgenic mouse. (C) Gait of SCA17 KI and KI/MANF mice was assessed with foot-printing assay. (D) KI/MANF mice show longer stride lengths in foot-printing test and shorter walking time in balance beam assay than SCA17 KI mice, indicating an improvement in gait performance and motor coordination (n = 6 each group, *p < 0.05). (E) Western blotting analysis of mutant TBP labeled by 1C2 antibody, transgenic MANF labeled by anti-HA, and calbindin in the cerebellum of 6-month-old SCA17 KI and KI/MANF mice. Actin was used as a loading control. The ratio of calbindin to actin is presented under the gel data (*p < 0.05). (F) Immunofluorescent staining images (103 by confocal microscope) of SCA17 KI and KI/MANF mouse cerebellum. Calbindin staining was used to reveal Purkinje neurons, and HA antibody was used to stain transgenic MANF. The scale bar represents 50 µm. (G) Quantitative assessment of the number of Purkinje neurons labeled by anticalbindin per image field, dendritic branches, and thickness of molecular layer (103, n = 9, *p < 0.05, **p < 0.01). (H) Coomassie staining of SDS gel containing total bacterial lysates and eluted His-MANF (arrowhead). (I) The purified His-MANF was applied to PC12 cells, and the PC12 cell lysates were collected 1, 2, 5, 10, and 20 min after MANF treatment and subjected to western blotting with an antibody to phosphor-PKC (pPKC). Actin was used as a loading control. The ratios of pPKC to actin are shown beneath the gel image (*p < 0.05). (J) Western blotting analysis of pPKC and PKCγ in the cerebellum of mice with different genotypes. The ratios of pPKC to actin are show under the gel image (*p < 0.05, **p < 0.01). (K) Immunofluorescent staining images of Purkinje neuron of SCA17 KI cerebellum injected with (+) or without (−) PKCγ adenovirus. Calbindin staining was used to reveal Purkinje neurons, and PKCγ antibody was used to detect viral PKCγ. The scale bar represents 50 µm. (L) Quantitative analysis of the number of Purkinje cells and their branches in KI mice injected with or without viral PKCγ (20×, n = 9, *p < 0.05). Data are represented as mean ± SEM.</div>
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<div id="mesh-terms" class="mesh-terms keywords-section">
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Cells, Cultured
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Estrogen Antagonists / pharmacology
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Gene Expression Regulation / genetics*
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HSC70 Heat-Shock Proteins / metabolism
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Immunoprecipitation
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||
</button><div id="keyword-actions-mesh-terms-9"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword Immunoprecipitation"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Immunoprecipitation%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Immunoprecipitation%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Immunoprecipitation"[MeSH]"
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data-ga-category="search"
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data-ga-action="mesh_term"
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data-ga-label="Immunoprecipitation">
|
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
||
ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Immunoprecipitation"
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data-ga-category="search_mesh"
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data-ga-action="mesh_term_link"
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data-ga-label="Immunoprecipitation">
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
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role="button"
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data-search-term=""Immunoprecipitation"[MeSH]"
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Immunoprecipitation"[MeSH]"
|
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href="#">
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Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Mice"
|
||
tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-10"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Mice
|
||
</button><div id="keyword-actions-mesh-terms-10"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
||
aria-label="Dropdown menu for keyword Mice"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Mice%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Mice%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Mice"[MeSH]"
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data-ga-category="search"
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data-ga-action="mesh_term"
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data-ga-label="Mice">
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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ref="linksrc=search_in_mesh_link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Mice"
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data-ga-category="search_mesh"
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data-ga-action="mesh_term_link"
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data-ga-label="Mice">
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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ref="linksrc=add_to_search_link"
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role="button"
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data-search-term=""Mice"[MeSH]"
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Mice"[MeSH]"
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href="#">
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
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aria-label="Toggle dropdown menu for keyword Mice, Inbred C57BL"
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tabindex="0"
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aria-controls="keyword-actions-mesh-terms-11"
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aria-expanded="false"
|
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data-pinger-ignore>
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Mice, Inbred C57BL
|
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</button><div id="keyword-actions-mesh-terms-11"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Mice, Inbred C57BL"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Mice%2C+Inbred+C57BL%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Mice%2C+Inbred+C57BL%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Mice, Inbred C57BL"[MeSH]"
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data-ga-action="mesh_term"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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ref="linksrc=search_in_mesh_link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Mice%2C+Inbred+C57BL"
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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data-search-term=""Mice, Inbred C57BL"[MeSH]"
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Mice, Inbred C57BL"[MeSH]"
|
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href="#">
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Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Mice, Transgenic"
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tabindex="0"
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aria-controls="keyword-actions-mesh-terms-12"
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aria-expanded="false"
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data-pinger-ignore>
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Mice, Transgenic
|
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</button><div id="keyword-actions-mesh-terms-12"
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
|
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aria-label="Dropdown menu for keyword Mice, Transgenic"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Mice%2C+Transgenic%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Mice%2C+Transgenic%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Mice, Transgenic"[MeSH]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Mice%2C+Transgenic"
|
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data-ga-category="search_mesh"
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data-ga-action="mesh_term_link"
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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role="button"
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data-search-term=""Mice, Transgenic"[MeSH]"
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Mice, Transgenic"[MeSH]"
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|
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Mutation / genetics"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-13"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Mutation / genetics
|
||
</button><div id="keyword-actions-mesh-terms-13"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
|
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aria-label="Dropdown menu for keyword Mutation / genetics"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Mutation%2Fgenetics%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Mutation%2Fgenetics%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Mutation/genetics"[MeSH]"
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data-ga-category="search"
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data-ga-action="mesh_term"
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data-ga-label="Mutation / genetics">
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Mutation"
|
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data-ga-category="search_mesh"
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data-ga-action="mesh_term_link"
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data-ga-label="Mutation / genetics">
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
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role="button"
|
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data-search-term=""Mutation/genetics"[MeSH]"
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Mutation/genetics"[MeSH]"
|
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href="#">
|
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Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major"
|
||
aria-label="Toggle dropdown menu for keyword Nerve Degeneration / pathology*"
|
||
tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-major-14"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Nerve Degeneration / pathology*
|
||
</button><div id="keyword-actions-mesh-terms-major-14"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
||
aria-label="Dropdown menu for keyword Nerve Degeneration / pathology*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Nerve+Degeneration%2Fpathology%22%5BMAJR%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Nerve+Degeneration%2Fpathology%22%5BMAJR%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Nerve Degeneration/pathology"[MAJR]"
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data-ga-category="search"
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data-ga-action="mesh_term"
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data-ga-label="Nerve Degeneration / pathology*">
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
||
ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Nerve+Degeneration"
|
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data-ga-category="search_mesh"
|
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data-ga-action="mesh_term_link"
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data-ga-label="Nerve Degeneration / pathology*">
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
|
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role="button"
|
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data-search-term=""Nerve Degeneration/pathology"[MAJR]"
|
||
data-ga-category="search"
|
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data-ga-action="add_to_search"
|
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data-ga-label=""Nerve Degeneration/pathology"[MAJR]"
|
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href="#">
|
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Nerve Growth Factors / genetics"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-15"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Nerve Growth Factors / genetics
|
||
</button><div id="keyword-actions-mesh-terms-15"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
||
aria-label="Dropdown menu for keyword Nerve Growth Factors / genetics"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Nerve+Growth+Factors%2Fgenetics%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Nerve+Growth+Factors%2Fgenetics%22%5BMeSH%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&mesh="Nerve Growth Factors/genetics"[MeSH]"
|
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data-ga-category="search"
|
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data-ga-action="mesh_term"
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data-ga-label="Nerve Growth Factors / genetics">
|
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Nerve+Growth+Factors"
|
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data-ga-category="search_mesh"
|
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data-ga-action="mesh_term_link"
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data-ga-label="Nerve Growth Factors / genetics">
|
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
|
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role="button"
|
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data-search-term=""Nerve Growth Factors/genetics"[MeSH]"
|
||
data-ga-category="search"
|
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data-ga-action="add_to_search"
|
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data-ga-label=""Nerve Growth Factors/genetics"[MeSH]"
|
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href="#">
|
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major"
|
||
aria-label="Toggle dropdown menu for keyword Nerve Growth Factors / metabolism*"
|
||
tabindex="0"
|
||
aria-controls="keyword-actions-mesh-terms-major-16"
|
||
aria-expanded="false"
|
||
data-pinger-ignore>
|
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Nerve Growth Factors / metabolism*
|
||
</button><div id="keyword-actions-mesh-terms-major-16"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword Nerve Growth Factors / metabolism*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Nerve+Growth+Factors%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Nerve+Growth+Factors%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&mesh="Nerve Growth Factors/metabolism"[MAJR]"
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data-ga-category="search"
|
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data-ga-action="mesh_term"
|
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data-ga-label="Nerve Growth Factors / metabolism*">
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Nerve+Growth+Factors"
|
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data-ga-category="search_mesh"
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data-ga-action="mesh_term_link"
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data-ga-label="Nerve Growth Factors / metabolism*">
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
|
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role="button"
|
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data-search-term=""Nerve Growth Factors/metabolism"[MAJR]"
|
||
data-ga-category="search"
|
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data-ga-action="add_to_search"
|
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data-ga-label=""Nerve Growth Factors/metabolism"[MAJR]"
|
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href="#">
|
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Peptides / metabolism"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-17"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Peptides / metabolism
|
||
</button><div id="keyword-actions-mesh-terms-17"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
||
aria-label="Dropdown menu for keyword Peptides / metabolism"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Peptides%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Peptides%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Peptides/metabolism"[MeSH]"
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data-ga-category="search"
|
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data-ga-action="mesh_term"
|
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data-ga-label="Peptides / metabolism">
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Peptides"
|
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data-ga-category="search_mesh"
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data-ga-action="mesh_term_link"
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data-ga-label="Peptides / metabolism">
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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ref="linksrc=add_to_search_link"
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role="button"
|
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data-search-term=""Peptides/metabolism"[MeSH]"
|
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Peptides/metabolism"[MeSH]"
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|
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
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aria-label="Toggle dropdown menu for keyword Protein Kinase C / metabolism"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-18"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Protein Kinase C / metabolism
|
||
</button><div id="keyword-actions-mesh-terms-18"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Protein Kinase C / metabolism"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Protein+Kinase+C%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Protein+Kinase+C%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Protein Kinase C/metabolism"[MeSH]"
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data-ga-category="search"
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data-ga-action="mesh_term"
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data-ga-label="Protein Kinase C / metabolism">
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=Protein+Kinase+C"
|
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data-ga-category="search_mesh"
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data-ga-label="Protein Kinase C / metabolism">
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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ref="linksrc=add_to_search_link"
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role="button"
|
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data-search-term=""Protein Kinase C/metabolism"[MeSH]"
|
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Protein Kinase C/metabolism"[MeSH]"
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href="#">
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major"
|
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aria-label="Toggle dropdown menu for keyword Purkinje Cells / pathology*"
|
||
tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-major-19"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Purkinje Cells / pathology*
|
||
</button><div id="keyword-actions-mesh-terms-major-19"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Purkinje Cells / pathology*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Purkinje+Cells%2Fpathology%22%5BMAJR%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Purkinje+Cells%2Fpathology%22%5BMAJR%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Purkinje Cells/pathology"[MAJR]"
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data-ga-category="search"
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data-ga-action="mesh_term"
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data-ga-label="Purkinje Cells / pathology*">
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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ref="linksrc=search_in_mesh_link"
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Regulatory Factor X Transcription Factors
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Transcription Factors / metabolism
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X-Box Binding Protein 1
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</div>
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|
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|
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<div id="substances" class="substances keywords-section">
|
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<h2 class="title">
|
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Substances
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</h2>
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<ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword DNA-Binding Proteins"
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DNA-Binding Proteins
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aria-label="Dropdown menu for keyword DNA-Binding Proteins"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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Search in PubMed
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Search in MeSH
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Estrogen Antagonists"
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tabindex="0"
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Estrogen Antagonists
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data-href="/?term=%22Estrogen+Antagonists%22%5Bnm%5D&sort=date&sort_order=desc"
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Search in PubMed
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Search in MeSH
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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HSC70 Heat-Shock Proteins
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Add to Search
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword MANF protein, mouse"
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MANF protein, mouse
|
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</button><div id="keyword-actions-substances-3"
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Search in MeSH
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Nerve Growth Factors"
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tabindex="0"
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Nerve Growth Factors
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Search in PubMed
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Search in MeSH
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|
||
data-search-term=""Nerve Growth Factors"[nm]"
|
||
data-ga-category="search"
|
||
data-ga-action="add_to_search"
|
||
data-ga-label=""Nerve Growth Factors"[nm]"
|
||
href="#">
|
||
Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Peptides"
|
||
tabindex="0"
|
||
aria-controls="keyword-actions-substances-5"
|
||
aria-expanded="false"
|
||
data-pinger-ignore>
|
||
Peptides
|
||
</button><div id="keyword-actions-substances-5"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword Peptides"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Peptides%22%5Bnm%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Peptides%22%5Bnm%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&keyword="Peptides"[nm]"
|
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data-ga-category="search"
|
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data-ga-action="substance"
|
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data-ga-label="Peptides">
|
||
Search in PubMed
|
||
</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
||
ref="linksrc=search_in_mesh_link"
|
||
href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Peptides%22"
|
||
data-ga-category="search_mesh"
|
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data-ga-action="substance_link"
|
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data-ga-label="Peptides">
|
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Search in MeSH
|
||
</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
|
||
role="button"
|
||
data-search-term=""Peptides"[nm]"
|
||
data-ga-category="search"
|
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data-ga-action="add_to_search"
|
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data-ga-label=""Peptides"[nm]"
|
||
href="#">
|
||
Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Regulatory Factor X Transcription Factors"
|
||
tabindex="0"
|
||
aria-controls="keyword-actions-substances-6"
|
||
aria-expanded="false"
|
||
data-pinger-ignore>
|
||
Regulatory Factor X Transcription Factors
|
||
</button><div id="keyword-actions-substances-6"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword Regulatory Factor X Transcription Factors"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Regulatory+Factor+X+Transcription+Factors%22%5Bnm%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22Regulatory+Factor+X+Transcription+Factors%22%5Bnm%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&keyword="Regulatory Factor X Transcription Factors"[nm]"
|
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data-ga-category="search"
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data-ga-action="substance"
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data-ga-label="Regulatory Factor X Transcription Factors">
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
||
ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Regulatory+Factor+X+Transcription+Factors%22"
|
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data-ga-category="search_mesh"
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data-ga-action="substance_link"
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data-ga-label="Regulatory Factor X Transcription Factors">
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
|
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role="button"
|
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data-search-term=""Regulatory Factor X Transcription Factors"[nm]"
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data-ga-category="search"
|
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data-ga-action="add_to_search"
|
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data-ga-label=""Regulatory Factor X Transcription Factors"[nm]"
|
||
href="#">
|
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Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword TATA-Box Binding Protein"
|
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tabindex="0"
|
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aria-controls="keyword-actions-substances-7"
|
||
aria-expanded="false"
|
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data-pinger-ignore>
|
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TATA-Box Binding Protein
|
||
</button><div id="keyword-actions-substances-7"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword TATA-Box Binding Protein"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22TATA-Box+Binding+Protein%22%5Bnm%5D&sort=date&sort_order=desc"
|
||
data-href="/?term=%22TATA-Box+Binding+Protein%22%5Bnm%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&keyword="TATA-Box Binding Protein"[nm]"
|
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data-ga-category="search"
|
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data-ga-action="substance"
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data-ga-label="TATA-Box Binding Protein">
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
||
ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=%22TATA-Box+Binding+Protein%22"
|
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data-ga-category="search_mesh"
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data-ga-action="substance_link"
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data-ga-label="TATA-Box Binding Protein">
|
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
||
ref="linksrc=add_to_search_link"
|
||
role="button"
|
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data-search-term=""TATA-Box Binding Protein"[nm]"
|
||
data-ga-category="search"
|
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data-ga-action="add_to_search"
|
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data-ga-label=""TATA-Box Binding Protein"[nm]"
|
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href="#">
|
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Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword TBP protein, human"
|
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tabindex="0"
|
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aria-controls="keyword-actions-substances-8"
|
||
aria-expanded="false"
|
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data-pinger-ignore>
|
||
TBP protein, human
|
||
</button><div id="keyword-actions-substances-8"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword TBP protein, human"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22TBP+protein%2C+human%22%5Bnm%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22TBP+protein%2C+human%22%5Bnm%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&keyword="TBP protein, human"[nm]"
|
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data-ga-category="search"
|
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data-ga-action="substance"
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data-ga-label="TBP protein, human">
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
||
ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=%22TBP+protein%2C+human%22"
|
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data-ga-category="search_mesh"
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data-ga-action="substance_link"
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data-ga-label="TBP protein, human">
|
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
|
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role="button"
|
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data-search-term=""TBP protein, human"[nm]"
|
||
data-ga-category="search"
|
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data-ga-action="add_to_search"
|
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data-ga-label=""TBP protein, human"[nm]"
|
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href="#">
|
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Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Transcription Factors"
|
||
tabindex="0"
|
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aria-controls="keyword-actions-substances-9"
|
||
aria-expanded="false"
|
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data-pinger-ignore>
|
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Transcription Factors
|
||
</button><div id="keyword-actions-substances-9"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
||
aria-label="Dropdown menu for keyword Transcription Factors"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Transcription+Factors%22%5Bnm%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Transcription+Factors%22%5Bnm%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&keyword="Transcription Factors"[nm]"
|
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data-ga-category="search"
|
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data-ga-action="substance"
|
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data-ga-label="Transcription Factors">
|
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Transcription+Factors%22"
|
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data-ga-category="search_mesh"
|
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data-ga-action="substance_link"
|
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data-ga-label="Transcription Factors">
|
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
|
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role="button"
|
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data-search-term=""Transcription Factors"[nm]"
|
||
data-ga-category="search"
|
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data-ga-action="add_to_search"
|
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data-ga-label=""Transcription Factors"[nm]"
|
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href="#">
|
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Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword X-Box Binding Protein 1"
|
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tabindex="0"
|
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aria-controls="keyword-actions-substances-10"
|
||
aria-expanded="false"
|
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data-pinger-ignore>
|
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X-Box Binding Protein 1
|
||
</button><div id="keyword-actions-substances-10"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword X-Box Binding Protein 1"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22X-Box+Binding+Protein+1%22%5Bnm%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22X-Box+Binding+Protein+1%22%5Bnm%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&keyword="X-Box Binding Protein 1"[nm]"
|
||
data-ga-category="search"
|
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data-ga-action="substance"
|
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data-ga-label="X-Box Binding Protein 1">
|
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=%22X-Box+Binding+Protein+1%22"
|
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data-ga-category="search_mesh"
|
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data-ga-action="substance_link"
|
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data-ga-label="X-Box Binding Protein 1">
|
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
|
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role="button"
|
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data-search-term=""X-Box Binding Protein 1"[nm]"
|
||
data-ga-category="search"
|
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data-ga-action="add_to_search"
|
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data-ga-label=""X-Box Binding Protein 1"[nm]"
|
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href="#">
|
||
Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword XBP1 protein, human"
|
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tabindex="0"
|
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aria-controls="keyword-actions-substances-11"
|
||
aria-expanded="false"
|
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data-pinger-ignore>
|
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XBP1 protein, human
|
||
</button><div id="keyword-actions-substances-11"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
||
aria-label="Dropdown menu for keyword XBP1 protein, human"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22XBP1+protein%2C+human%22%5Bnm%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22XBP1+protein%2C+human%22%5Bnm%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&keyword="XBP1 protein, human"[nm]"
|
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data-ga-category="search"
|
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data-ga-action="substance"
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data-ga-label="XBP1 protein, human">
|
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=%22XBP1+protein%2C+human%22"
|
||
data-ga-category="search_mesh"
|
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data-ga-action="substance_link"
|
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data-ga-label="XBP1 protein, human">
|
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Search in MeSH
|
||
</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
|
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role="button"
|
||
data-search-term=""XBP1 protein, human"[nm]"
|
||
data-ga-category="search"
|
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data-ga-action="add_to_search"
|
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data-ga-label=""XBP1 protein, human"[nm]"
|
||
href="#">
|
||
Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Xbp1 protein, mouse"
|
||
tabindex="0"
|
||
aria-controls="keyword-actions-substances-12"
|
||
aria-expanded="false"
|
||
data-pinger-ignore>
|
||
Xbp1 protein, mouse
|
||
</button><div id="keyword-actions-substances-12"
|
||
class="keyword-actions-dropdown dropdown dropdown-container"
|
||
hidden
|
||
aria-label="Dropdown menu for keyword Xbp1 protein, mouse"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
||
href="/?term=%22Xbp1+protein%2C+mouse%22%5Bnm%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Xbp1+protein%2C+mouse%22%5Bnm%5D&sort=date&sort_order=desc"
|
||
ref="linksrc=search_in_pubmed_keyword_link&keyword="Xbp1 protein, mouse"[nm]"
|
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data-ga-category="search"
|
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data-ga-action="substance"
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data-ga-label="Xbp1 protein, mouse">
|
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Search in PubMed
|
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
|
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ref="linksrc=search_in_mesh_link"
|
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href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Xbp1+protein%2C+mouse%22"
|
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data-ga-category="search_mesh"
|
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data-ga-action="substance_link"
|
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data-ga-label="Xbp1 protein, mouse">
|
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Search in MeSH
|
||
</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
|
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role="button"
|
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data-search-term=""Xbp1 protein, mouse"[nm]"
|
||
data-ga-category="search"
|
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data-ga-action="add_to_search"
|
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data-ga-label=""Xbp1 protein, mouse"[nm]"
|
||
href="#">
|
||
Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
||
aria-label="Toggle dropdown menu for keyword Tamoxifen"
|
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tabindex="0"
|
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aria-controls="keyword-actions-substances-13"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Tamoxifen
|
||
</button><div id="keyword-actions-substances-13"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Tamoxifen"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Tamoxifen%22%5Bnm%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Tamoxifen%22%5Bnm%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&keyword="Tamoxifen"[nm]"
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data-ga-category="search"
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data-ga-action="substance"
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data-ga-label="Tamoxifen">
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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ref="linksrc=search_in_mesh_link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Tamoxifen%22"
|
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data-ga-category="search_mesh"
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data-ga-action="substance_link"
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data-ga-label="Tamoxifen">
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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ref="linksrc=add_to_search_link"
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role="button"
|
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data-search-term=""Tamoxifen"[nm]"
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Tamoxifen"[nm]"
|
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href="#">
|
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Add to Search
|
||
</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
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aria-label="Toggle dropdown menu for keyword polyglutamine"
|
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tabindex="0"
|
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aria-controls="keyword-actions-substances-14"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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polyglutamine
|
||
</button><div id="keyword-actions-substances-14"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword polyglutamine"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22polyglutamine%22%5Bnm%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22polyglutamine%22%5Bnm%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&keyword="polyglutamine"[nm]"
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data-ga-category="search"
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data-ga-action="substance"
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data-ga-label="polyglutamine">
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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href="https://www.ncbi.nlm.nih.gov/mesh?term=%22polyglutamine%22"
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data-ga-category="search_mesh"
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data-ga-action="substance_link"
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data-ga-label="polyglutamine">
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Search in MeSH
|
||
</a></li><li><a class="add-to-search-link dropdown-block-link"
|
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ref="linksrc=add_to_search_link"
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role="button"
|
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data-search-term=""polyglutamine"[nm]"
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""polyglutamine"[nm]"
|
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href="#">
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
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aria-label="Toggle dropdown menu for keyword Protein Kinase C"
|
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tabindex="0"
|
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aria-controls="keyword-actions-substances-15"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Protein Kinase C
|
||
</button><div id="keyword-actions-substances-15"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Protein Kinase C"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Protein+Kinase+C%22%5Bnm%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Protein+Kinase+C%22%5Bnm%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&keyword="Protein Kinase C"[nm]"
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data-ga-category="search"
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