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{"id":12434,"date":"2023-11-14T11:28:48","date_gmt":"2023-11-14T16:28:48","guid":{"rendered":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/?p=12434"},"modified":"2023-11-14T11:28:48","modified_gmt":"2023-11-14T16:28:48","slug":"refseq-release-221","status":"publish","type":"post","link":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/11\/14\/refseq-release-221\/","title":{"rendered":"RefSeq Release 221"},"content":{"rendered":"<p>RefSeq release 221 is now available <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/refseq\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-release-221-20231114\">online<\/a>\u00a0and from the\u00a0<a href=\"https:\/\/ftp.ncbi.nlm.nih.gov\/refseq\/release\/\">FTP<\/a>\u00a0site. You can access RefSeq data through\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/datasets\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-release-221-20231114\">NCBI Datasets<\/a>.<\/p>\n<h5>What\u2019s included in this release?<\/h5>\n<p>As of November 6, 2023, this full release incorporates genomic, transcript, and protein data containing:<\/p>\n<ul>\n<li><span style=\"font-size: 17px;\">404,657,610 records<\/span><\/li>\n<li><span style=\"font-size: 17px;\">300,054,945 proteins<\/span><\/li>\n<li><span style=\"font-size: 17px;\">57,882,313 RNAs<\/span><\/li>\n<li><span style=\"font-size: 17px;\">sequences from 143,819 organisms\u00a0<\/span><\/li>\n<\/ul>\n<p><!--more--><\/p>\n<p>The release is provided in several directories as a complete dataset and divided by logical groupings.<\/p>\n<h5>Human genome annotation update<\/h5>\n<h6>Assembly GRCh38.p14<\/h6>\n<ul>\n<li><span style=\"font-size: 17px;\">Annotation Release <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/genome\/annotation_euk\/Homo_sapiens\/GCF_000001405.40-RS_2023_10\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-release-221-20231114\">GCF_000001405.40-RS_2023_10<\/a> is an update of NCBI Homo sapiens Annotation Release 110, incorporating the latest set of curated RefSeq transcript changes.<\/span><\/li>\n<li><span style=\"font-size: 17px;\">The annotation products are available in the sequence databases and on the <a href=\"https:\/\/ftp.ncbi.nlm.nih.gov\/genomes\/all\/annotation_releases\/9606\/GCF_000001405.40-RS_2023_10\/\">FTP site<\/a>.<\/span><\/li>\n<\/ul>\n<h6>Assembly T2T-CHM13v2.0<\/h6>\n<ul>\n<li><span style=\"font-size: 17px;\">Annotation Release <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/genome\/annotation_euk\/Homo_sapiens\/GCF_009914755.1-RS_2023_10\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-release-221-20231114\">GCF_009914755.1-RS_2023_10<\/a> is an update of NCBI Homo sapiens Annotation Release 110, incorporating the latest set of curated RefSeq transcript changes.<\/span><\/li>\n<li><span style=\"font-size: 17px;\">The annotation products are available in the sequence databases and on the <a href=\"https:\/\/ftp.ncbi.nlm.nih.gov\/genomes\/all\/annotation_releases\/9606\/GCF_009914755.1-RS_2023_10\/\">FTP site<\/a>.<\/span><br \/>\n<b style=\"font-family: Merriweather; font-size: 1rem;\"><\/b><\/li>\n<\/ul>\n<h5>New eukaryotic genome annotations<\/h5>\n<p>This release includes new annotations generated by NCBI’s eukaryotic genome annotation pipeline for 36 additional species, including:<\/p>\n<ul>\n<li><span style=\"font-size: 17px;\">Cow, based on updated assembly ARS-UCD2.0 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/datasets\/genome\/GCF_002263795.3\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-release-221-20231114\">GCF_002263795.3_2023_09<\/a>)\u00a0<\/span><\/li>\n<li><span style=\"font-size: 17px;\">Mongolian gerbil, based on new assembly Bangor_MerUng_6.1 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/datasets\/genome\/GCF_030254825.1\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-release-221-20231114\">GCF_030254825.1_2023_10<\/a>) <em>(pictured)<\/em><\/span><\/li>\n<li><span style=\"font-size: 17px;\">Common lizard, based on new assembly Bangor_MerUng_6.1 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/datasets\/genome\/GCF_963506605.1\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-release-221-20231114\">GCF_963506605.1_2023_10<\/a>)<\/span><\/li>\n<li><span style=\"font-size: 17px;\">House finch, based on new assembly bHaeMex1.pri (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/datasets\/genome\/GCF_027477595.1\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-release-221-20231114\">GCF_027477595.1_2023_09<\/a>)\u00a0<\/span><\/li>\n<li><span style=\"font-size: 17px;\">Wine grape, based on new assembly ASM3070453v1 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/datasets\/genome\/GCF_030704535.1\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-release-221-20231114\">GCF_030704535.1_2023_09<\/a>)\u00a0<\/span><\/li>\n<li><span style=\"font-size: 17px;\">Sweet potato weevil, based on new assembly icCylForm1.1 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/datasets\/genome\/GCF_029955315.1\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-release-221-20231114\">GCF_029955315.1_2023_10<\/a>)\u00a0<\/span><\/li>\n<\/ul>\n<h5><b>Future changes<\/b><\/h5>\n<p>We plan to rename the *.nonredundant_protein* files to clarify that the files are specific to the prokaryote WP protein dataset. You should continue to use all complete.*protein.* files if you wish to obtain a complete set of RefSeq proteins across all represented taxa.<\/p>\n<h4>Stay up to date<\/h4>\n<p>RefSeq is part of the\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/comparative-genomics-resource\/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-release-221-20231113\">NIH Comparative Genomics Resource (CGR)<\/a>. <span data-contrast=\"none\">CGR facilitates reliable comparative genomics analyses\u202ffor all eukaryotic organisms through an NCBI Toolkit and community collaboration.\u00a0<\/span><span class=\"TextRun Highlight SCXW148001688 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW148001688 BCX8\">Follow us on social\u202f<\/span><\/span><a class=\"Hyperlink SCXW148001688 BCX8\" href=\"https:\/\/twitter.com\/ncbi\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"TextRun Highlight SCXW148001688 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW148001688 BCX8\" data-ccp-charstyle=\"Hyperlink\">@NCBI<\/span><\/span><\/a>\u00a0and\u00a0<a class=\"external-link\" href=\"https:\/\/public.govdelivery.com\/accounts\/USNLMOCPL\/subscriber\/new?topic_id=USNLMOCPL_50%22\" rel=\"nofollow\">join our mailing list<\/a>\u00a0to keep up to date with RefSeq and other CGR news.<\/p>\n<h4>Questions?<\/h4>\n<p><span data-contrast=\"auto\">If you have questions or would like to provide feedback, please\u00a0<a href=\"https:\/\/support.nlm.nih.gov\/support\/create-case\/\">reach out<\/a>\u00a0to us!<\/span><span data-contrast=\"auto\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>RefSeq release 221 is now available online\u00a0and from the\u00a0FTP\u00a0site. You can access RefSeq data through\u00a0NCBI Datasets. What\u2019s included in this release? As of November 6, 2023, this full release incorporates genomic, transcript, and protein data containing: 404,657,610 records 300,054,945 proteins 57,882,313 RNAs sequences from 143,819 organisms\u00a0<\/p>\n","protected":false},"author":42204617,"featured_media":12447,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"RefSeq Release 221!","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2248],"tags":[693060768,574294629,91552,693060836,27739816],"table_tags":[],"class_list":["post-12434","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-whats-new","tag-comparative-genomics-resource-cgr","tag-eukaryotic-genome-annotation","tag-human-genome","tag-ncbi-datasets","tag-refseq"],"jetpack_publicize_connections":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>RefSeq Release 221 - NCBI Insights<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/11\/14\/refseq-release-221\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"RefSeq Release 221 - NCBI Insights\" \/>\n<meta property=\"og:description\" content=\"RefSeq release 221 is now available online\u00a0and from the\u00a0FTP\u00a0site. You can access RefSeq data through\u00a0NCBI Datasets. What\u2019s included in this release? 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