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/* vietnamese */
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/* cyrillic */
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/* vietnamese */
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font-display: swap;
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/* latin-ext */
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font-display: swap;
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/* latin */
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/* latin */
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2021/02/'> February 2021 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2021/01/'> January 2021 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2020/12/'> December 2020 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2020/11/'> November 2020 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2020/04/'> April 2020 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2020/03/'> March 2020 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2020/02/'> February 2020 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2020/01/'> January 2020 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2019/12/'> December 2019 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2019/11/'> November 2019 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2019/10/'> October 2019 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2019/02/'> February 2019 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2019/01/'> January 2019 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2018/12/'> December 2018 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2018/10/'> October 2018 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2018/03/'> March 2018 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2018/02/'> February 2018 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2018/01/'> January 2018 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2017/12/'> December 2017 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2017/11/'> November 2017 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2017/10/'> October 2017 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2017/09/'> September 2017 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2017/08/'> August 2017 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2017/07/'> July 2017 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2017/06/'> June 2017 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2017/05/'> May 2017 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2017/04/'> April 2017 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2017/03/'> March 2017 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2017/02/'> February 2017 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2017/01/'> January 2017 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2016/12/'> December 2016 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2016/11/'> November 2016 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2016/10/'> October 2016 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2016/09/'> September 2016 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2016/07/'> July 2016 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2016/05/'> May 2016 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2016/03/'> March 2016 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2016/02/'> February 2016 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2016/01/'> January 2016 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2015/10/'> October 2015 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2015/09/'> September 2015 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2015/08/'> August 2015 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2015/07/'> July 2015 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2015/05/'> May 2015 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2015/04/'> April 2015 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2015/03/'> March 2015 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2015/02/'> February 2015 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2014/12/'> December 2014 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2014/10/'> October 2014 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2014/08/'> August 2014 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2014/06/'> June 2014 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2014/05/'> May 2014 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2014/04/'> April 2014 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2014/03/'> March 2014 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2014/01/'> January 2014 </option>
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||
<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2013/12/'> December 2013 </option>
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||
<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2013/11/'> November 2013 </option>
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||
<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2013/10/'> October 2013 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2013/09/'> September 2013 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2013/07/'> July 2013 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2013/06/'> June 2013 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2013/04/'> April 2013 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2013/03/'> March 2013 </option>
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||
<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2013/02/'> February 2013 </option>
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<option value='https://ncbiinsights.ncbi.nlm.nih.gov/2013/01/'> January 2013 </option>
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||
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</select>
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</aside><aside id="block-2" class="widget widget_block"><a href="https://www.ncbi.nlm.nih.gov/books/NBK1969/">NCBI News Archive 1994-2017</a></aside> </div>
|
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</div><!-- #secondary -->
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<div id="primary" class="content-area">
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<main id="main" class="site-main" role="main">
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<article id="post-13930" class="post-13930 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-comparative-genomics-resource-cgr tag-eukaryote-genome-annotation-pipeline-egap tag-ncbi-datasets tag-refseq">
|
||
<div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/17/refseq-release-226-is-available/"><img width="1108" height="737" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/iStock-1210474851-e1726525917284.jpg?resize=1100%2C551&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="RefSeq Release 226 is Available!" decoding="async" fetchpriority="high" data-attachment-id="13939" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/17/refseq-release-226-is-available/zebrafish-zebra-barb-danio-rerio-freshwater-aquarium-fish/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/iStock-1210474851-e1726525917284.jpg?fit=1100%2C551&ssl=1" data-orig-size="1100,551" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"Getty Images\/iStockphoto","camera":"","caption":"Zebrafish Zebra Barb Danio rerio freshwater aquarium fish","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"Zebrafish Zebra Barb Danio rerio freshwater aquarium fish","orientation":"0"}" data-image-title="Zebrafish Zebra Barb Danio rerio freshwater aquarium fish" data-image-description="" data-image-caption="<p>Zebrafish Zebra Barb Danio rerio freshwater aquarium fish</p>
|
||
" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/iStock-1210474851-e1726525917284.jpg?fit=300%2C150&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/iStock-1210474851-e1726525917284.jpg?fit=1024%2C513&ssl=1" /></a></div><!-- .post-image-link -->
|
||
<header class="entry-header">
|
||
<h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/17/refseq-release-226-is-available/" rel="bookmark">RefSeq Release 226 is Available!</a></h1> </header><!-- .entry-header -->
|
||
|
||
<div class="entry-content">
|
||
<p>Check out RefSeq release 226, now available <a href="https://www.ncbi.nlm.nih.gov/refseq/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-release-226-20240917">online</a> and from the <a href="https://ftp.ncbi.nlm.nih.gov/refseq/release/">FTP</a> site. You can access RefSeq data through <a href="https://www.ncbi.nlm.nih.gov/datasets/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-release-226-20240917">NCBI Datasets</a>. The release is provided in several directories as a complete dataset and also divided by logical groupings.</p>
|
||
<h5>What’s included in this release?</h5>
|
||
<p>As of September 13, 2024, this full release incorporates genomic, transcript, and protein data containing:</p>
|
||
<ul>
|
||
<li><span style="font-size: 17px;">472,512,852 records</span></li>
|
||
<li><span style="font-size: 17px;">355,355,673 proteins</span></li>
|
||
<li><span style="font-size: 17px;">65,576,846 RNAs</span></li>
|
||
<li><span style="font-size: 17px;">Sequences from 155,792 organisms</span></li>
|
||
</ul>
|
||
<p> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/17/refseq-release-226-is-available/#more-13930" class="more-link">Continue reading <span class="screen-reader-text">“RefSeq Release 226 is Available!”</span> <span class="meta-nav">→</span></a></p>
|
||
|
||
</div><!-- .entry-content -->
|
||
|
||
<footer class="entry-footer">
|
||
<ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/17/refseq-release-226-is-available/" rel="bookmark"><time class="entry-date published updated" datetime="2024-09-17T10:35:50-04:00">September 17, 2024</time></a></li></ul><!-- .post-metadata --> <div class="meta-wrapper">
|
||
<ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/comparative-genomics-resource-cgr/" rel="tag">Comparative Genomics Resource (CGR)</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/eukaryote-genome-annotation-pipeline-egap/" rel="tag">Eukaryote Genome Annotation Pipeline (EGAP)</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/ncbi-datasets/" rel="tag">NCBI Datasets</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/refseq/" rel="tag">RefSeq</a></li></ul><!-- .post-tags --> </div><!-- .meta-wrapper -->
|
||
</footer><!-- .entry-footer -->
|
||
</article><!-- #post-## -->
|
||
|
||
|
||
<article id="post-13918" class="post-13918 post type-post status-publish format-standard hentry category-whats-new tag-pgap tag-rapt">
|
||
|
||
<header class="entry-header">
|
||
<h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/16/rapt-to-retire-december-2024/" rel="bookmark">NCBI’s Read Assembly and Annotation Pipeline Tool (RAPT) to Retire December 2024</a></h1> </header><!-- .entry-header -->
|
||
|
||
<div class="entry-content">
|
||
<p>As of December 2024, NCBI’s pilot tool, <a href="https://github.com/ncbi/rapt">Read Assembly and Annotation Pipeline Tool (RAPT)</a> will no longer be available.</p>
|
||
<p>We encourage you to check out NCBI’s suite of assembly and annotation tools including the genome assembler <a href="https://pubmed.ncbi.nlm.nih.gov/30286803?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=rapt-sunset-20240916">SKESA</a>, the taxonomic assignment tool <a href="https://pubmed.ncbi.nlm.nih.gov/29792589?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=rapt-sunset-20240916">ANI</a>, and the prokaryotic genome annotation pipeline (<a href="https://pubmed.ncbi.nlm.nih.gov/33270901?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=rapt-sunset-20240916">PGAP</a>).</p>
|
||
<h5><strong>Stay up to date</strong></h5>
|
||
<p>Follow us on social <a href="https://twitter.com/ncbi">@NCBI</a> and <a href="https://public.govdelivery.com/accounts/USNLMOCPL/subscriber/new?topic_id=USNLMOCPL_52">join our mailing list</a> to keep up to date with NCBI news.</p>
|
||
<h5><strong>Questions?</strong></h5>
|
||
<p>Feel free to contact our help desk at <a href="mailto:info@ncbi.nlm.nih.gov">info@ncbi.nlm.nih.gov</a> if you have any questions or concerns.</p>
|
||
|
||
</div><!-- .entry-content -->
|
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|
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<footer class="entry-footer">
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<ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/16/rapt-to-retire-december-2024/" rel="bookmark"><time class="entry-date published updated" datetime="2024-09-16T10:06:53-04:00">September 16, 2024</time></a></li></ul><!-- .post-metadata --> <div class="meta-wrapper">
|
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<ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/pgap/" rel="tag">NCBI Prokaryotic Genome Annotation Pipeline (PGAP)</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/rapt/" rel="tag">Read assembly and Annotation Pipeline Tool (RAPT)</a></li></ul><!-- .post-tags --> </div><!-- .meta-wrapper -->
|
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</footer><!-- .entry-footer -->
|
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</article><!-- #post-## -->
|
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|
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|
||
<article id="post-13902" class="post-13902 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-cloud-computing tag-sra">
|
||
<div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/11/sra-data-access-amazon-web-services-aws/"><img width="1108" height="627" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/SRA_AWS-e1725997492633.png?resize=1100%2C575&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="Changes to SRA Data Access on Amazon Web Services (AWS)" decoding="async" data-attachment-id="13905" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/11/sra-data-access-amazon-web-services-aws/sra_aws/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/SRA_AWS-e1725997492633.png?fit=1100%2C575&ssl=1" data-orig-size="1100,575" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="SRA_AWS" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/SRA_AWS-e1725997492633.png?fit=300%2C157&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/SRA_AWS-e1725997492633.png?fit=1024%2C535&ssl=1" /></a></div><!-- .post-image-link -->
|
||
<header class="entry-header">
|
||
<h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/11/sra-data-access-amazon-web-services-aws/" rel="bookmark">Changes to SRA Data Access on Amazon Web Services (AWS)</a></h1> </header><!-- .entry-header -->
|
||
|
||
<div class="entry-content">
|
||
<h3><i><span data-contrast="none">Cost-effective alternatives for accessing SRA data</span></i><span data-contrast="auto"> </span><span data-ccp-props="{}"> </span></h3>
|
||
<p><span data-contrast="auto">Important note! The storage tier for </span><a href="https://www.ncbi.nlm.nih.gov/sra?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=sra-aws-access-20240911"><span data-contrast="none">Sequence Read Archive (SRA)</span></a><span data-contrast="auto"> data available through </span><a href="https://www.ncbi.nlm.nih.gov/sra/docs/sra-aws-download/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=sra-aws-access-20240911"><span data-contrast="none">Amazon Web Services (AWS)</span></a><span data-contrast="auto"> commercial buckets is transitioning to </span><a href="https://aws.amazon.com/efs/features/infrequent-access/"><span data-contrast="none">Infrequent Access</span></a><span data-contrast="auto">. This change is projected to be complete by the end of September 2024. </span><span data-contrast="auto">To mitigate the cost impact of this change, we recommend adjusting your data access workflow to utilize the SRA Toolkit for accessing SRA data. </span><a href="https://aws.amazon.com/s3/pricing/"><span data-contrast="none">Read more</span></a><span data-contrast="auto">.</span><span data-ccp-props="{}"> </span></p>
|
||
<p><span data-contrast="auto">Please note this change does not impact SRA data access from </span><a href="https://www.ncbi.nlm.nih.gov/sra/docs/SRA-Google-Cloud/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=sra-aws-access-20240911"><span data-contrast="none">Google Cloud Platform (GCP)</span></a><span data-contrast="auto"> or </span><a href="https://www.ncbi.nlm.nih.gov/sra/docs/sradownload/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=sra-aws-access-20240911"><span data-contrast="none">NCBI servers</span></a><span data-contrast="auto">. </span><span data-ccp-props="{}"> </span> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/11/sra-data-access-amazon-web-services-aws/#more-13902" class="more-link">Continue reading <span class="screen-reader-text">“Changes to SRA Data Access on Amazon Web Services (AWS)”</span> <span class="meta-nav">→</span></a></p>
|
||
|
||
</div><!-- .entry-content -->
|
||
|
||
<footer class="entry-footer">
|
||
<ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/11/sra-data-access-amazon-web-services-aws/" rel="bookmark"><time class="entry-date published updated" datetime="2024-09-11T09:46:27-04:00">September 11, 2024</time></a></li></ul><!-- .post-metadata --> <div class="meta-wrapper">
|
||
<ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/cloud-computing/" rel="tag">Cloud computing</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/sra/" rel="tag">Sequence Read Archive (SRA)</a></li></ul><!-- .post-tags --> </div><!-- .meta-wrapper -->
|
||
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<article id="post-13893" class="post-13893 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-clinvar">
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<div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/10/improving-representation-functional-data-clinvar/"><img width="1108" height="627" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/ClinVar_Functional_Data-2-e1725978340923.png?resize=1100%2C575&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="Coming Soon! Improving Representation of Functional Data in ClinVar" decoding="async" data-attachment-id="13896" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/10/improving-representation-functional-data-clinvar/clinvar_functional_data-2/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/ClinVar_Functional_Data-2-e1725978340923.png?fit=1100%2C575&ssl=1" data-orig-size="1100,575" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="ClinVar_Functional_Data (2)" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/ClinVar_Functional_Data-2-e1725978340923.png?fit=300%2C157&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/ClinVar_Functional_Data-2-e1725978340923.png?fit=1024%2C535&ssl=1" /></a></div><!-- .post-image-link -->
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<header class="entry-header">
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<h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/10/improving-representation-functional-data-clinvar/" rel="bookmark">Coming Soon! Improving Representation of Functional Data in ClinVar</a></h1> </header><!-- .entry-header -->
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<div class="entry-content">
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<p><span data-contrast="auto">NCBI is improving the way that functional data are submitted to </span><a href="https://www.ncbi.nlm.nih.gov/clinvar/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=clinvar-functional-data-20240910"><span data-contrast="none">ClinVar</span></a><span data-contrast="auto"> and how they are represented in the XML format and on the website. Almost half of the variants in ClinVar are variants of uncertain significance (VUS). It’s unclear what clinical action to take for these variants, creating a challenge for clinicians. One potential way to resolve VUS is to develop functional assays to determine the effect the variant has on the gene product, at either the transcript or the protein level. While ClinVar can currently accept functional data, we are striving to make submission easier and more efficient and to make the data easier to find and use. </span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335557856":16777215,"335559740":240}"> </span> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/10/improving-representation-functional-data-clinvar/#more-13893" class="more-link">Continue reading <span class="screen-reader-text">“Coming Soon! Improving Representation of Functional Data in ClinVar”</span> <span class="meta-nav">→</span></a></p>
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||
</div><!-- .entry-content -->
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<footer class="entry-footer">
|
||
<ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/10/improving-representation-functional-data-clinvar/" rel="bookmark"><time class="entry-date published updated" datetime="2024-09-10T10:48:10-04:00">September 10, 2024</time></a></li></ul><!-- .post-metadata --> <div class="meta-wrapper">
|
||
<ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/clinvar/" rel="tag">ClinVar</a></li></ul><!-- .post-tags --> </div><!-- .meta-wrapper -->
|
||
</footer><!-- .entry-footer -->
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</article><!-- #post-## -->
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<article id="post-13873" class="post-13873 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-geo">
|
||
<div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/04/submitting-sequence-data-gene-expression-omnibus/"><img width="1108" height="627" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/Submit_GEO_Blog-1-e1725463807436.png?resize=1100%2C575&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="Submitting High-Throughput Sequence Data to Gene Expression Omnibus (GEO)" decoding="async" loading="lazy" data-attachment-id="13876" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/04/submitting-sequence-data-gene-expression-omnibus/submit_geo_blog-1/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/Submit_GEO_Blog-1-e1725463807436.png?fit=1100%2C575&ssl=1" data-orig-size="1100,575" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="Submit_GEO_Blog (1)" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/Submit_GEO_Blog-1-e1725463807436.png?fit=300%2C157&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/Submit_GEO_Blog-1-e1725463807436.png?fit=1024%2C535&ssl=1" /></a></div><!-- .post-image-link -->
|
||
<header class="entry-header">
|
||
<h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/04/submitting-sequence-data-gene-expression-omnibus/" rel="bookmark">Submitting High-Throughput Sequence Data to Gene Expression Omnibus (GEO)</a></h1> </header><!-- .entry-header -->
|
||
|
||
<div class="entry-content">
|
||
<p><span data-contrast="auto">Submit your transcriptomic and epigenomic data to </span><a href="https://www.ncbi.nlm.nih.gov/geo/?utm_source=ncbi_insights&utm_medium=referral&utm_term=geo-submit-20240904"><span data-contrast="none">Gene Expression Omnibus (GEO</span></a><span data-contrast="auto">)</span><span data-contrast="none">! GEO is a </span><span data-contrast="auto">public functional genomics data repository that relies on your data submissions. We are pleased to announce a new submission interface to improve your experience. </span><span data-ccp-props="{}"> </span></p>
|
||
<h5><b><span data-contrast="auto">What’s new?</span></b><span data-ccp-props="{}"> </span></h5>
|
||
<ul>
|
||
<li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span style="font-size: 17px;">A web interface for uploading your GEO metadata </span></li>
|
||
<li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span style="font-size: 17px;">Metadata immediately validated for format and completeness </span></li>
|
||
<li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span style="font-size: 17px;">Errors reported instantly with how-to-fix instructions </span></li>
|
||
<li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span style="font-size: 17px;">Faster submission processing </span></li>
|
||
</ul>
|
||
<p> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/04/submitting-sequence-data-gene-expression-omnibus/#more-13873" class="more-link">Continue reading <span class="screen-reader-text">“Submitting High-Throughput Sequence Data to Gene Expression Omnibus (GEO)”</span> <span class="meta-nav">→</span></a></p>
|
||
|
||
</div><!-- .entry-content -->
|
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|
||
<footer class="entry-footer">
|
||
<ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/04/submitting-sequence-data-gene-expression-omnibus/" rel="bookmark"><time class="entry-date published updated" datetime="2024-09-04T12:30:55-04:00">September 4, 2024</time></a></li></ul><!-- .post-metadata --> <div class="meta-wrapper">
|
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<ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/geo/" rel="tag">Gene Expression Omnibus (GEO)</a></li></ul><!-- .post-tags --> </div><!-- .meta-wrapper -->
|
||
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|
||
</article><!-- #post-## -->
|
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|
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|
||
<article id="post-13817" class="post-13817 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-pathogen-detection">
|
||
<div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/03/milestone-ncbi-pathogen-detection-2m-isolates/"><img width="1108" height="627" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/PD_2M_Isolates-1-e1725376444404.png?resize=1100%2C575&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="New Milestone! NCBI Pathogen Detection Reaches 2 Million Isolates" decoding="async" loading="lazy" data-attachment-id="13825" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/03/milestone-ncbi-pathogen-detection-2m-isolates/pd_2m_isolates-1/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/PD_2M_Isolates-1-e1725376444404.png?fit=1100%2C575&ssl=1" data-orig-size="1100,575" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="PD_2M_Isolates (1)" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/PD_2M_Isolates-1-e1725376444404.png?fit=300%2C157&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/09/PD_2M_Isolates-1-e1725376444404.png?fit=1024%2C535&ssl=1" /></a></div><!-- .post-image-link -->
|
||
<header class="entry-header">
|
||
<h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/03/milestone-ncbi-pathogen-detection-2m-isolates/" rel="bookmark">New Milestone! NCBI Pathogen Detection Reaches 2 Million Isolates</a></h1> </header><!-- .entry-header -->
|
||
|
||
<div class="entry-content">
|
||
<p>NCBI’s <a href="https://www.ncbi.nlm.nih.gov/pathogens/?utm_source=ncbi_insights&utm_medium=referral&utm_term=pathogen-detection-milestone-20240903">Pathogen Detection</a> resource collects, analyzes, and reports on bacterial and fungal isolate genome sequences for outbreak identification and tracking. Pathogen Detection is also central to the surveillance of anti-microbial resistance, virulence, and stress resistance for <a href="https://www.ncbi.nlm.nih.gov/pathogens/organisms/?utm_source=ncbi_insights&utm_medium=referral&utm_term=pathogen-detection-milestone-20240903">97 pathogenic taxa</a> covering 753 species, and now includes analysis results for over <a href="https://www.ncbi.nlm.nih.gov/pathogens/isolates/?utm_source=ncbi_insights&utm_medium=referral&utm_term=pathogen-detection-milestone-20240903">2 million isolates</a>!</p>
|
||
<h5>How does Pathogen Detection work?</h5>
|
||
<p>Pathogen Detection provides two major automated real-time analyses:</p>
|
||
<ol>
|
||
<li><span style="font-size: 17px;">It quickly clusters related pathogen genome sequences to identify potential transmission chains helping public health scientists investigate disease outbreaks.</span></li>
|
||
<li><span style="font-size: 17px;">As part of the <a href="https://www.ncbi.nlm.nih.gov/pathogens/antimicrobial-resistance/?utm_source=ncbi_insights&utm_medium=referral&utm_term=pathogen-detection-milestone-20240903">National Database of Antibiotic Resistant Organisms (NDARO),</a> NCBI screens genomic sequences using <a href="https://github.com/ncbi/amr/wiki">AMRFinderPlus</a> to identify the antimicrobial resistance, stress response, and virulence genes found in bacterial genomic sequences. This enables scientists to track the spread of resistance genes and to understand the relationships among antimicrobial resistance, stress response, and virulence. </span></li>
|
||
</ol>
|
||
<p> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/03/milestone-ncbi-pathogen-detection-2m-isolates/#more-13817" class="more-link">Continue reading <span class="screen-reader-text">“New Milestone! NCBI Pathogen Detection Reaches 2 Million Isolates”</span> <span class="meta-nav">→</span></a></p>
|
||
|
||
</div><!-- .entry-content -->
|
||
|
||
<footer class="entry-footer">
|
||
<ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/09/03/milestone-ncbi-pathogen-detection-2m-isolates/" rel="bookmark"><time class="entry-date published updated" datetime="2024-09-03T15:34:46-04:00">September 3, 2024</time></a></li></ul><!-- .post-metadata --> <div class="meta-wrapper">
|
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<ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/pathogen-detection/" rel="tag">NCBI Pathogen Detection</a></li></ul><!-- .post-tags --> </div><!-- .meta-wrapper -->
|
||
</footer><!-- .entry-footer -->
|
||
</article><!-- #post-## -->
|
||
|
||
|
||
<article id="post-13805" class="post-13805 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-ncbi-datasets tag-taxonomy">
|
||
<div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/08/29/ncbi-taxonomy-updates-to-yeasts/"><img width="1108" height="627" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/08/Yeast_NCBI-Taxonomy-2-e1724881206977.png?resize=1100%2C575&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="NCBI Taxonomy Updates to Yeasts" decoding="async" loading="lazy" data-attachment-id="13811" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/08/29/ncbi-taxonomy-updates-to-yeasts/yeast_ncbi-taxonomy-2/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/08/Yeast_NCBI-Taxonomy-2-e1724881206977.png?fit=1100%2C575&ssl=1" data-orig-size="1100,575" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="Yeast_NCBI Taxonomy (2)" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/08/Yeast_NCBI-Taxonomy-2-e1724881206977.png?fit=300%2C157&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/08/Yeast_NCBI-Taxonomy-2-e1724881206977.png?fit=1024%2C535&ssl=1" /></a></div><!-- .post-image-link -->
|
||
<header class="entry-header">
|
||
<h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/08/29/ncbi-taxonomy-updates-to-yeasts/" rel="bookmark">NCBI Taxonomy Updates to Yeasts</a></h1> </header><!-- .entry-header -->
|
||
|
||
<div class="entry-content">
|
||
<p><span data-contrast="auto">As </span><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/06/04/changes-ncbi-taxonomy-classifications/?utm_source=ncbi_insights&utm_medium=referral&utm_term=taxonomy-yeast-20240829"><span data-contrast="none">previously announced</span></a><span data-contrast="auto">, NCBI is continually making improvements to our </span><a href="https://www.ncbi.nlm.nih.gov/taxonomy?utm_source=ncbi_insights&utm_medium=referral&utm_term=taxonomy-yeast-20240829"><span data-contrast="none">Taxonomy</span></a><span data-contrast="auto"> resource in response to new data and changes in biological nomenclature. We recently made classification changes to budding yeasts and allies (</span><a href="https://www.ncbi.nlm.nih.gov/datasets/taxonomy/147537/?utm_source=ncbi_insights&utm_medium=referral&utm_term=taxonomy-yeast-20240829"><span data-contrast="none">Saccharomycotina</span></a><span data-contrast="auto">), which consists of more than 1,200 species and exhibits levels of genomic diversity similar to those of plants and animals. This update affects more than six million records.</span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335557856":16777215,"335559740":240}"> Check out our new <a href="https://www.ncbi.nlm.nih.gov/datasets/taxonomy/147537/?utm_source=ncbi_insights&utm_medium=referral&utm_term=taxonomy-yeast-20240829">Taxonomy browser</a> in NCBI Datasets. </span> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/08/29/ncbi-taxonomy-updates-to-yeasts/#more-13805" class="more-link">Continue reading <span class="screen-reader-text">“NCBI Taxonomy Updates to Yeasts”</span> <span class="meta-nav">→</span></a></p>
|
||
|
||
</div><!-- .entry-content -->
|
||
|
||
<footer class="entry-footer">
|
||
<ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/08/29/ncbi-taxonomy-updates-to-yeasts/" rel="bookmark"><time class="entry-date published" datetime="2024-08-29T10:25:42-04:00">August 29, 2024</time><time class="updated" datetime="2024-08-29T10:47:33-04:00">August 29, 2024</time></a></li></ul><!-- .post-metadata --> <div class="meta-wrapper">
|
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<ul class="post-tags"><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/ncbi-datasets/" rel="tag">NCBI Datasets</a></li><li><a href="https://ncbiinsights.ncbi.nlm.nih.gov/tag/taxonomy/" rel="tag">NCBI Taxonomy</a></li></ul><!-- .post-tags --> </div><!-- .meta-wrapper -->
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</article><!-- #post-## -->
|
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|
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|
||
<article id="post-13782" class="post-13782 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-genbank">
|
||
<div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/08/26/now-available-genbank-release-262-0/"><img width="1108" height="627" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/08/GenBank_Release-15-e1724684557666.png?resize=1100%2C575&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="Now Available: GenBank Release 262.0!" decoding="async" loading="lazy" data-attachment-id="13790" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/08/26/now-available-genbank-release-262-0/genbank_release-15/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/08/GenBank_Release-15-e1724684557666.png?fit=1100%2C575&ssl=1" data-orig-size="1100,575" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="GenBank_Release (15)" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/08/GenBank_Release-15-e1724684557666.png?fit=300%2C157&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/08/GenBank_Release-15-e1724684557666.png?fit=1024%2C535&ssl=1" /></a></div><!-- .post-image-link -->
|
||
<header class="entry-header">
|
||
<h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/08/26/now-available-genbank-release-262-0/" rel="bookmark">Now Available: GenBank Release 262.0!</a></h1> </header><!-- .entry-header -->
|
||
|
||
<div class="entry-content">
|
||
<header></header>
|
||
<p><a href="https://www.ncbi.nlm.nih.gov/genbank/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=genbank-release-262-20240826">GenBank</a> release 262.0 (8/22/2024) is now available on the <a href="https://ftp.ncbi.nlm.nih.gov/genbank/">NCBI FTP site</a>. This release has 34.10 trillion bases and 4.76 billion records.</p>
|
||
<p><strong>The current release has: </strong></p>
|
||
<ul>
|
||
<li><span style="font-size: 17px;">251,998,350 traditional records containing 3,675,462,701,077 base pairs of sequence data</span></li>
|
||
<li><span style="font-size: 17px;">3,569,715,357 WGS records containing 29,643,594,176,326 base pairs of sequence data</span></li>
|
||
<li><span style="font-size: 17px;">755,907,377 bulk-oriented TSA records containing 706,085,554,263 base pairs of sequence data</span></li>
|
||
<li><span style="font-size: 17px;">187,321,998 bulk-oriented TLS records containing 77,026,446,552 base pairs of sequence data </span></li>
|
||
</ul>
|
||
<p> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/08/26/now-available-genbank-release-262-0/#more-13782" class="more-link">Continue reading <span class="screen-reader-text">“Now Available: GenBank Release 262.0!”</span> <span class="meta-nav">→</span></a></p>
|
||
|
||
</div><!-- .entry-content -->
|
||
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<article id="post-13763" class="post-13763 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-hidden-markov-models-hmm tag-pgap tag-protein-family-model tag-refseq">
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<div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/08/22/hmm-release-16-now-available/"><img width="1108" height="627" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/08/HMM_Release-8-e1724266030383.png?resize=1100%2C575&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="NCBI Hidden Markov Models (HMM) Release 16.0 Now Available!" decoding="async" loading="lazy" data-attachment-id="13765" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/08/22/hmm-release-16-now-available/hmm_release-8/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/08/HMM_Release-8-e1724266030383.png?fit=1100%2C575&ssl=1" data-orig-size="1100,575" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="HMM_Release (8)" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/08/HMM_Release-8-e1724266030383.png?fit=300%2C157&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/08/HMM_Release-8-e1724266030383.png?fit=1024%2C535&ssl=1" /></a></div><!-- .post-image-link -->
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<header class="entry-header">
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<h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/08/22/hmm-release-16-now-available/" rel="bookmark">NCBI Hidden Markov Models (HMM) Release 16.0 Now Available!</a></h1> </header><!-- .entry-header -->
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<div class="entry-content">
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<p><a href="https://ftp.ncbi.nlm.nih.gov/hmm/16.0/">Download release 16.0</a> of the NCBI protein profile Hidden Markov models (HMMs) used by the <a class="external-link" href="https://www.ncbi.nlm.nih.gov/refseq/annotation_prok/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=hmm-release-16-20240822" target="_blank" rel="nofollow noopener">Prokaryotic Genome Annotation Pipeline (PGAP)</a>! Search this collection against your favorite prokaryotic proteins to identify their function using the <a class="external-link" href="http://eddylab.org/software/hmmer/Userguide.pdf" target="_blank" rel="nofollow noopener">HMMER sequence analysis package</a>.</p>
|
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<h5>What’s New?</h5>
|
||
<p>Release 16.0 contains:</p>
|
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<ul>
|
||
<li><span style="font-size: 17px;">17,078 HMMs maintained by NCBI</span></li>
|
||
<li><span style="font-size: 17px;">406 new HMMs since release 15.0</span></li>
|
||
<li><span style="font-size: 17px;">The GO terms between NCBI HMMs and the corresponding <a class="external-link" href="https://www.ebi.ac.uk/interpro/" target="_blank" rel="nofollow noopener">Interpro</a> entries were compared and evaluated over a substantial number of HMMs and updated (added: 307; deleted: 39; updated: 1,482). </span></li>
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</ul>
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<p> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/08/22/hmm-release-16-now-available/#more-13763" class="more-link">Continue reading <span class="screen-reader-text">“NCBI Hidden Markov Models (HMM) Release 16.0 Now Available!”</span> <span class="meta-nav">→</span></a></p>
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<ul class="post-meta"><li class="author vcard"><a class="url fn n" href="https://ncbiinsights.ncbi.nlm.nih.gov/author/ncbiinsights/">NCBI Staff</a></li><li class="posted-on"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/08/22/hmm-release-16-now-available/" rel="bookmark"><time class="entry-date published" datetime="2024-08-22T10:24:37-04:00">August 22, 2024</time><time class="updated" datetime="2024-08-26T10:05:20-04:00">August 26, 2024</time></a></li></ul><!-- .post-metadata --> <div class="meta-wrapper">
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<article id="post-13751" class="post-13751 post type-post status-publish format-standard has-post-thumbnail hentry category-whats-new tag-genbank tag-ncbi-datasets tag-ncbi-virus tag-sra">
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<div class="post-image-link"><a rel="bookmark" href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/08/21/access-mpox-data-through-ncbi-virus/"><img width="1108" height="627" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/08/mpox_blog-1-e1724249484776.png?resize=1100%2C575&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="Quick & Easy Access to Mpox Data Through NCBI Virus" decoding="async" loading="lazy" data-attachment-id="13757" data-permalink="https://ncbiinsights.ncbi.nlm.nih.gov/2024/08/21/access-mpox-data-through-ncbi-virus/mpox_blog-1/" data-orig-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/08/mpox_blog-1-e1724249484776.png?fit=1100%2C575&ssl=1" data-orig-size="1100,575" data-comments-opened="1" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="mpox_blog (1)" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/08/mpox_blog-1-e1724249484776.png?fit=300%2C157&ssl=1" data-large-file="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/08/mpox_blog-1-e1724249484776.png?fit=1024%2C535&ssl=1" /></a></div><!-- .post-image-link -->
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<h1 class="entry-title"><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/08/21/access-mpox-data-through-ncbi-virus/" rel="bookmark">Quick & Easy Access to Mpox Data Through NCBI Virus</a></h1> </header><!-- .entry-header -->
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<p><span data-contrast="none">The </span><a href="https://www.who.int/news/item/14-08-2024-who-director-general-declares-mpox-outbreak-a-public-health-emergency-of-international-concern"><span data-contrast="none">World Health Organization (WHO)</span></a> <span data-contrast="none">declared the</span><span data-contrast="none"> recent </span><span data-contrast="none">upsurge of the mpox virus to be a public health emergency of international concern. Having timely viral genome data freely and widely available enables researchers to explore how this virus differs from viruses isolated and sequenced in the past. </span><span data-contrast="none">Therefore, NCBI’s <a href="https://www.ncbi.nlm.nih.gov/genbank/?utm_source=ncbi_insights&utm_medium=referral&utm_term=virus-mpox-20240821">GenBank</a> is expediting the release of mpox data by annotating gene and coding region features as part of the submission process</span><span data-contrast="none">.</span><span data-ccp-props="{}"> </span> <a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/08/21/access-mpox-data-through-ncbi-virus/#more-13751" class="more-link">Continue reading <span class="screen-reader-text">“Quick & Easy Access to Mpox Data Through NCBI Virus”</span> <span class="meta-nav">→</span></a></p>
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