87 lines
61 KiB
HTML
87 lines
61 KiB
HTML
<!DOCTYPE html>
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/*# sourceURL=/css/ampshared.css*/</style><meta property="og:locale" content="en_US"><meta property="og:type" content="article"><meta property="og:title" content="New! Introducing the Multiple Comparative Genome Viewer (MCGV) Beta Release - NCBI Insights"><meta property="og:description" content="NLM’s NCBI is excited to introduce the Multiple Comparative Genome Viewer (MCGV), a new tool in active development that allows you to visualize an alignment of multiple eukaryotic genomes. While our existing Comparative Genome Viewer (CGV) allows you to compare pairs of eukaryotic assemblies, the new MCGV tool can help you analyze multiple assemblies in … Continue reading New! Introducing the Multiple Comparative Genome Viewer (MCGV) Beta Release →"><meta property="og:url" content="https://ncbiinsights.ncbi.nlm.nih.gov/2025/01/16/new-mcgv-beta-release/"><meta property="og:site_name" content="NCBI Insights"><meta property="article:publisher" content="https://www.facebook.com/ncbi.nlm"><meta property="article:published_time" content="2025-01-16T15:12:44+00:00"><meta property="og:image" content="https://ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_BLOG-1-e1736957172355.png"><meta property="og:image:width" content="1100"><meta property="og:image:height" content="575"><meta property="og:image:type" content="image/png"><meta name="author" content="NCBI Staff"><meta name="twitter:card" content="summary_large_image"><meta name="twitter:creator" content="@NCBI"><meta name="twitter:site" content="@NCBI"><meta name="twitter:label1" content="Written by"><meta name="twitter:data1" content="NCBI Staff"><meta name="twitter:label2" content="Est. reading 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<h1 class="amp-wp-title">New! Introducing the Multiple Comparative Genome Viewer (MCGV) Beta Release</h1>
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2 months ago </time>
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<amp-img width="1024" height="535" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_BLOG-1-e1736957172355.png?fit=1024%2C535&ssl=1" class="attachment-large size-large wp-post-image amp-wp-enforced-sizes i-amphtml-layout-intrinsic i-amphtml-layout-size-defined" alt="Yellow banner in corner yes NEW! Text says: Multiple Comparative Genome Viewer. New Visualization Tool" data-hero-candidate="" layout="intrinsic" data-hero i-amphtml-ssr i-amphtml-layout="intrinsic"><i-amphtml-sizer slot="i-amphtml-svc" class="i-amphtml-sizer"><img alt="" aria-hidden="true" class="i-amphtml-intrinsic-sizer" role="presentation" src="data:image/svg+xml;base64,PHN2ZyBoZWlnaHQ9IjUzNSIgd2lkdGg9IjEwMjQiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyIgdmVyc2lvbj0iMS4xIi8+"></i-amphtml-sizer><img class="i-amphtml-fill-content i-amphtml-replaced-content" decoding="async" loading="lazy" alt="Yellow banner in corner yes NEW! Text says: Multiple Comparative Genome Viewer. New Visualization Tool" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_BLOG-1-e1736957172355.png?fit=1024%2C535&ssl=1"></amp-img> </figure>
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<p><span data-contrast="auto">NLM’s NCBI is excited to introduce the </span><a href="https://www.ncbi.nlm.nih.gov/mcgv/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=mcgv-introduction-20250116"><span data-contrast="none">Multiple Comparative Genome Viewer (MCGV)</span></a><span data-contrast="auto">, a new tool in active development that allows you to visualize an alignment of multiple eukaryotic genomes. While our existing </span><a href="https://www.ncbi.nlm.nih.gov/cgv/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=mcgv-introduction-20250116"><span data-contrast="none">Comparative Genome Viewer (CGV)</span></a><span data-contrast="auto"> allows you to compare pairs of eukaryotic assemblies, the new MCGV tool can help you analyze multiple assemblies in a single view. </span><span data-ccp-props='{"201341983":0,"335559738":150,"335559739":0,"335559740":240}'> </span></p>
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<p><span data-contrast="auto">MCGV displays are based on multiple whole genome sequence alignments. You can navigate these alignments in the viewer to track evolutionarily related regions across strains or species. Focus in on a particular genome region to investigate how differences in genome structure may have contributed to differences in gene sequence and function. You can access MCGV by clicking on the “Visualize gene across species” link via the gene search results page. </span><span data-ccp-props='{"201341983":0,"335559738":150,"335559739":0,"335559740":240}'> </span></p>
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<h5>Learn more</h5>
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<p><span data-contrast="auto">Learn more about MCGV from the figures below. </span><span data-ccp-props='{"201341983":0,"335559738":150,"335559739":0,"335559740":240}'> </span></p>
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<p><amp-img class="alignright size-full wp-image-14389 amp-wp-enforced-sizes i-amphtml-layout-intrinsic i-amphtml-layout-size-defined" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_1.png?resize=1108%2C113&ssl=1" alt="Screenshot of MCGV " width="1108" height="113" srcset="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_1.png?w=1610&ssl=1 1610w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_1.png?resize=300%2C31&ssl=1 300w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_1.png?resize=1024%2C104&ssl=1 1024w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_1.png?resize=150%2C15&ssl=1 150w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_1.png?resize=768%2C78&ssl=1 768w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_1.png?resize=1536%2C156&ssl=1 1536w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_1.png?resize=270%2C28&ssl=1 270w" sizes="auto, (max-width: 1108px) 100vw, 1108px" layout="intrinsic" disable-inline-width="" i-amphtml-layout="intrinsic"><i-amphtml-sizer slot="i-amphtml-svc" class="i-amphtml-sizer"><img alt="" aria-hidden="true" class="i-amphtml-intrinsic-sizer" role="presentation" src="data:image/svg+xml;base64,PHN2ZyBoZWlnaHQ9IjExMyIgd2lkdGg9IjExMDgiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyIgdmVyc2lvbj0iMS4xIi8+"></i-amphtml-sizer><noscript><img loading="lazy" decoding="async" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_1.png?resize=1108%2C113&ssl=1" alt="Screenshot of MCGV " width="1108" height="113" srcset="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_1.png?w=1610&ssl=1 1610w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_1.png?resize=300%2C31&ssl=1 300w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_1.png?resize=1024%2C104&ssl=1 1024w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_1.png?resize=150%2C15&ssl=1 150w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_1.png?resize=768%2C78&ssl=1 768w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_1.png?resize=1536%2C156&ssl=1 1536w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_1.png?resize=270%2C28&ssl=1 270w" sizes="auto, (max-width: 1108px) 100vw, 1108px"></noscript></amp-img></p>
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<p><span data-contrast="auto"><em>Figure 1. MCGV <a href="https://www.ncbi.nlm.nih.gov/mcgv/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=mcgv-introduction-20250116">chromosome overview</a> displaying the number of assemblies aligned at each location along a chromosome of the anchor assembly (e.g. human GRCh38). Select a region to zoom in the viewer and investigate further.</em> </span><span data-ccp-props='{"201341983":0,"335559738":150,"335559739":0,"335559740":240}'> </span></p>
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<p><span data-ccp-props='{"201341983":0,"335559738":150,"335559739":0,"335559740":240}'> <amp-img class="alignright size-full wp-image-14390 amp-wp-enforced-sizes i-amphtml-layout-intrinsic i-amphtml-layout-size-defined" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_2.png?resize=1108%2C559&ssl=1" alt="MCGV screenshot" width="1108" height="559" srcset="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_2.png?w=1514&ssl=1 1514w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_2.png?resize=300%2C151&ssl=1 300w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_2.png?resize=1024%2C517&ssl=1 1024w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_2.png?resize=150%2C76&ssl=1 150w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_2.png?resize=768%2C388&ssl=1 768w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_2.png?resize=270%2C136&ssl=1 270w" sizes="auto, (max-width: 1108px) 100vw, 1108px" layout="intrinsic" disable-inline-width="" i-amphtml-layout="intrinsic"><i-amphtml-sizer slot="i-amphtml-svc" class="i-amphtml-sizer"><img alt="" aria-hidden="true" class="i-amphtml-intrinsic-sizer" role="presentation" src="data:image/svg+xml;base64,PHN2ZyBoZWlnaHQ9IjU1OSIgd2lkdGg9IjExMDgiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyIgdmVyc2lvbj0iMS4xIi8+"></i-amphtml-sizer><noscript><img loading="lazy" decoding="async" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_2.png?resize=1108%2C559&ssl=1" alt="MCGV screenshot" width="1108" height="559" srcset="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_2.png?w=1514&ssl=1 1514w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_2.png?resize=300%2C151&ssl=1 300w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_2.png?resize=1024%2C517&ssl=1 1024w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_2.png?resize=150%2C76&ssl=1 150w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_2.png?resize=768%2C388&ssl=1 768w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_2.png?resize=270%2C136&ssl=1 270w" sizes="auto, (max-width: 1108px) 100vw, 1108px"></noscript></amp-img></span></p>
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<p><em>Figure 2: MCGV <a href="https://ncbi.nlm.nih.gov/mcgv/browse/epo33/NC_000001.11/113000000/117000000/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=mcgv-introduction-20250116">alignment view</a> showing alignments for different genome assembles. Blue segments represent alignment blocks. Darker shades of blue signify more similarity to an anchor assembly, e.g. human GRCh38. The RefSeq gene annotation is also shown for the anchor assembly (green bars). </em></p>
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<p><amp-img class="alignright size-full wp-image-14391 amp-wp-enforced-sizes i-amphtml-layout-intrinsic i-amphtml-layout-size-defined" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_3.png?resize=1108%2C284&ssl=1" alt="Screenshot of MCGV" width="1108" height="284" srcset="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_3.png?w=1607&ssl=1 1607w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_3.png?resize=300%2C77&ssl=1 300w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_3.png?resize=1024%2C263&ssl=1 1024w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_3.png?resize=150%2C38&ssl=1 150w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_3.png?resize=768%2C197&ssl=1 768w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_3.png?resize=1536%2C394&ssl=1 1536w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_3.png?resize=270%2C69&ssl=1 270w" sizes="auto, (max-width: 1108px) 100vw, 1108px" layout="intrinsic" disable-inline-width="" i-amphtml-layout="intrinsic"><i-amphtml-sizer slot="i-amphtml-svc" class="i-amphtml-sizer"><img alt="" aria-hidden="true" class="i-amphtml-intrinsic-sizer" role="presentation" src="data:image/svg+xml;base64,PHN2ZyBoZWlnaHQ9IjI4NCIgd2lkdGg9IjExMDgiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyIgdmVyc2lvbj0iMS4xIi8+"></i-amphtml-sizer><noscript><img loading="lazy" decoding="async" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_3.png?resize=1108%2C284&ssl=1" alt="Screenshot of MCGV" width="1108" height="284" srcset="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_3.png?w=1607&ssl=1 1607w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_3.png?resize=300%2C77&ssl=1 300w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_3.png?resize=1024%2C263&ssl=1 1024w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_3.png?resize=150%2C38&ssl=1 150w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_3.png?resize=768%2C197&ssl=1 768w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_3.png?resize=1536%2C394&ssl=1 1536w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2025/01/MCGV_Screenshot_3.png?resize=270%2C69&ssl=1 270w" sizes="auto, (max-width: 1108px) 100vw, 1108px"></noscript></amp-img><em>Figure 3: MCGV <a href="https://ncbi.nlm.nih.gov/mcgv/browse/epo33/NC_000023.11/28587500/28587800/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=mcgv-introduction-20250116">sequence conservation panel</a>. This graph reports the proportion of aligned sequences containing perfect matches (dark blue) or mismatches or gaps (light blue) at each position in a gene region.</em><span data-ccp-props='{"201341983":0,"335559738":150,"335559739":0,"335559740":240}'> </span></p>
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<h5>We want to hear from you!</h5>
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<p><span data-contrast="none">Try it out and let us know what you think. We will be adding new functionality to MCGV in the coming months, such as expanded gene annotation and view customization options. We would like to know what improvements would be most helpful to your research. Please </span><a href="https://support.nlm.nih.gov/support/create-case/"><span data-contrast="none">reach out to us</span></a> <span data-contrast="none">using the yellow feedback button on the bottom of the webpage with your questions or feedback. Also, please contact us if there are other publicly available multiple whole genome sequence alignment datasets you’d like to see in MCGV. </span><span data-ccp-props='{"201341983":0,"335559738":150,"335559739":0,"335559740":240}'> </span></p>
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<p><span data-contrast="auto">MCGV is part of the </span><a href="https://www.ncbi.nlm.nih.gov/datasets/cgr?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=mcgv-introduction-20250116"><span data-contrast="none">NIH Comparative Genomics Resource (CGR)</span></a><span data-contrast="auto">. CGR facilitates reliable comparative genomics analyses for all eukaryotic organisms through an NCBI Toolkit and community collaboration. </span><span data-ccp-props='{"201341983":0,"335559738":150,"335559739":0,"335559740":240}'> </span></p>
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<p><a href="https://public.govdelivery.com/accounts/USNLMOCPL/subscriber/new?topic_id=USNLMOCPL_50%22"><span data-contrast="none">Join our mailing list</span></a><span data-contrast="auto"> to keep up to date with MCGV and other CGR news. </span><span data-ccp-props='{"201341983":0,"335559738":150,"335559739":0,"335559740":240}'> </span></p>
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