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/*# sourceURL=/css/ampshared.css*/</style><meta property="og:locale" content="en_US"><meta property="og:type" content="article"><meta property="og:title" content="Now Available! NCBI Hidden Markov Models (HMM) Release 17.0 - NCBI Insights"><meta property="og:description" content="Download release 17.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the Prokaryotic Genome Annotation Pipeline (PGAP). Search this collection against your favorite prokaryotic proteins to identify their function using the HMMER sequence analysis package. Whats New? Release 17.0 contains: 17,433 HMMs maintained by NCBI 386 new HMMs since release 16.0 You can search … Continue reading Now Available! NCBI Hidden Markov Models (HMM) Release 17.0 →"><meta property="og:url" content="https://ncbiinsights.ncbi.nlm.nih.gov/2024/12/18/ncbi-hidden-markov-models-release-17-0/"><meta property="og:site_name" content="NCBI Insights"><meta property="article:publisher" content="https://www.facebook.com/ncbi.nlm"><meta property="article:published_time" content="2024-12-18T15:53:08+00:00"><meta property="og:image" content="https://ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/12/HMM_Release-9-e1734462625364.png"><meta property="og:image:width" content="1100"><meta property="og:image:height" content="575"><meta property="og:image:type" content="image/png"><meta name="author" content="NCBI Staff"><meta name="twitter:card" content="summary_large_image"><meta name="twitter:creator" content="@NCBI"><meta name="twitter:site" content="@NCBI"><meta name="twitter:label1" content="Written by"><meta name="twitter:data1" content="NCBI Staff"><meta name="twitter:label2" content="Est. reading 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NCBI Hidden Markov Models (HMM) Release 17.0 - NCBI Insights</title></head>
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<h1 class="amp-wp-title">Now Available! NCBI Hidden Markov Models (HMM) Release 17.0</h1>
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<amp-img width="1024" height="535" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/12/HMM_Release-9-e1734462625364.png?fit=1024%2C535&amp;ssl=1" class="attachment-large size-large wp-post-image amp-wp-enforced-sizes i-amphtml-layout-intrinsic i-amphtml-layout-size-defined" alt="Colorful squares in the background with letters, ATGC, representing base pairs inside. Text says: HMM Release 17.0 Download Now!" data-hero-candidate="" layout="intrinsic" data-hero i-amphtml-ssr i-amphtml-layout="intrinsic"><i-amphtml-sizer slot="i-amphtml-svc" class="i-amphtml-sizer"><img alt="" aria-hidden="true" class="i-amphtml-intrinsic-sizer" role="presentation" src="data:image/svg+xml;base64,PHN2ZyBoZWlnaHQ9IjUzNSIgd2lkdGg9IjEwMjQiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyIgdmVyc2lvbj0iMS4xIi8+"></i-amphtml-sizer><img class="i-amphtml-fill-content i-amphtml-replaced-content" decoding="async" loading="lazy" alt="Colorful squares in the background with letters, ATGC, representing base pairs inside. Text says: HMM Release 17.0 Download Now!" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/12/HMM_Release-9-e1734462625364.png?fit=1024%2C535&amp;ssl=1"></amp-img> </figure>
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<p><a href="https://ftp.ncbi.nlm.nih.gov/hmm/17.0/">Download release 17.0</a> of the NCBI protein profile Hidden Markov models (HMMs) used by the <a class="external-link" href="https://www.ncbi.nlm.nih.gov/refseq/annotation_prok/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=hmm-release-17-20241218" target="_blank" rel="nofollow noopener">Prokaryotic Genome Annotation Pipeline (PGAP)</a>. Search this collection against your favorite prokaryotic proteins to identify their function using the <a class="external-link" href="http://eddylab.org/software/hmmer/Userguide.pdf" target="_blank" rel="nofollow noopener">HMMER sequence analysis package</a>.</p>
<h5>Whats New?</h5>
<p>Release 17.0 contains:</p>
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<li><span data-amp-original-style="font-size: 17px;" class="amp-wp-8bdd01f">17,433 HMMs maintained by NCBI</span></li>
<li><span data-amp-original-style="font-size: 17px;" class="amp-wp-8bdd01f">386 new HMMs since release 16.0</span></li>
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<p>You can search and view the details for these in the <a class="external-link" href="https://www.ncbi.nlm.nih.gov/protfam?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=hmm-release-17-20241218" target="_blank" rel="nofollow noopener">Protein Family Model</a> collection, which also includes conserved domain architectures and BlastRules, and access all <a class="external-link" href="https://www.ncbi.nlm.nih.gov/refseq/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=hmm-release-17-20241218" target="_blank" rel="nofollow noopener">RefSeq</a> proteins that these models name.</p>
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