87 lines
55 KiB
HTML
87 lines
55 KiB
HTML
<!DOCTYPE html>
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<html amp lang="en-US" data-amp-auto-lightbox-disable transformed="self;v=1" i-amphtml-layout="" i-amphtml-no-boilerplate="">
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/*# sourceURL=/css/ampshared.css*/</style><meta property="og:locale" content="en_US"><meta property="og:type" content="article"><meta property="og:title" content="Submit Your Somatic Variation Data to ClinVar - NCBI Insights"><meta property="og:description" content="NCBI’s ClinVar is now accepting submissions for somatic variants classified for cancer. As recently announced, we updated the ClinVar website as part of our effort to better support the display of submitted somatic variation data. Access to somatic variation data is essential for understanding tumor biology and will help researchers advance cancer treatment. It also … Continue reading Submit Your Somatic Variation Data to ClinVar →"><meta property="og:url" content="https://ncbiinsights.ncbi.nlm.nih.gov/2024/02/29/submit-somatic-data-to-clinvar/"><meta property="og:site_name" content="NCBI Insights"><meta property="article:publisher" content="https://www.facebook.com/ncbi.nlm"><meta property="article:published_time" content="2024-02-29T16:50:02+00:00"><meta property="og:image" content="https://ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/02/Submit_ClinVar-Somatic-Data-1-e1709153119718.png"><meta property="og:image:width" content="1100"><meta property="og:image:height" content="575"><meta property="og:image:type" content="image/png"><meta name="author" content="NCBI Staff"><meta name="twitter:card" content="summary_large_image"><meta name="twitter:creator" content="@NCBI"><meta name="twitter:site" content="@NCBI"><meta name="twitter:label1" content="Written by"><meta name="twitter:data1" content="NCBI Staff"><meta 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<h1 class="amp-wp-title">Submit Your Somatic Variation Data to ClinVar</h1>
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<amp-img width="1024" height="535" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/02/Submit_ClinVar-Somatic-Data-1-e1709153119718.png?fit=1024%2C535&ssl=1" class="attachment-large size-large wp-post-image amp-wp-enforced-sizes i-amphtml-layout-intrinsic i-amphtml-layout-size-defined" alt="Keyboard in the background with a person's finger pressing a blue submit button. Text says: ClinVar, Submit your somatic variation data." data-hero-candidate="" layout="intrinsic" data-hero i-amphtml-ssr i-amphtml-layout="intrinsic"><i-amphtml-sizer slot="i-amphtml-svc" class="i-amphtml-sizer"><img alt="" aria-hidden="true" class="i-amphtml-intrinsic-sizer" role="presentation" src="data:image/svg+xml;base64,PHN2ZyBoZWlnaHQ9IjUzNSIgd2lkdGg9IjEwMjQiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyIgdmVyc2lvbj0iMS4xIi8+"></i-amphtml-sizer><img class="i-amphtml-fill-content i-amphtml-replaced-content" decoding="async" loading="lazy" alt="Keyboard in the background with a person's finger pressing a blue submit button. Text says: ClinVar, Submit your somatic variation data." src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/02/Submit_ClinVar-Somatic-Data-1-e1709153119718.png?fit=1024%2C535&ssl=1"></amp-img> </figure>
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<p><span data-contrast="auto">NCBI’s </span><a href="https://www.ncbi.nlm.nih.gov/clinvar?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=clinvar-submit-somatic-data-20240229"><span data-contrast="none">ClinVar</span></a><span data-contrast="auto"> is now accepting submissions for somatic variants classified for cancer. As </span><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2024/01/31/enhancements-clinvar-website-live/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=clinvar-submit-somatic-data-20240229"><span data-contrast="none">recently announced</span></a><span data-contrast="auto">, we updated the ClinVar website as part of our effort to better support the display of submitted </span><a href="https://ncbiinsights.ncbi.nlm.nih.gov/2023/02/01/clinvar-support-for-somatic-data/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=clinvar-submit-somatic-data-20240229"><span data-contrast="none">somatic variation data</span></a><span data-contrast="auto">. </span><span data-ccp-props='{"134233117":true,"134233118":true,"201341983":0,"335559740":240}'> </span></p>
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<p><span data-contrast="auto">Access to somatic variation data is essential for understanding tumor biology and will help researchers advance cancer treatment. It also helps clinical cancer testing laboratories provide better patient reports. Make ClinVar as useful for somatic variants as it is for germline by contributing your data! </span><span data-contrast="auto">To submit your data, use our new somatic spreadsheet template </span><span data-contrast="none">(SubmissionTemplateSomatic.xlsx) </span><span data-contrast="auto">and follow these </span><a href="https://www.ncbi.nlm.nih.gov/clinvar/docs/spreadsheet/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=clinvar-submit-somatic-data-20240229#somatic"><span data-contrast="none">step-by-step instructions</span></a><span data-contrast="auto">. Once your submission is prepared, you can go to the </span><a href="https://submit.ncbi.nlm.nih.gov/clinvar/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=clinvar-submit-somatic-data-20240229"><span data-contrast="none">ClinVar Submission Portal</span></a><span data-contrast="auto"> to upload and send your file. See an example below. </span><span data-ccp-props='{"134233117":true,"134233118":true,"201341983":0,"335559740":240}'> </span></p>
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<p><amp-img class="alignright size-full wp-image-12929 amp-wp-enforced-sizes i-amphtml-layout-intrinsic i-amphtml-layout-size-defined" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/02/ClinVar_Screenshot-1.png?resize=1108%2C630&ssl=1" alt="Table to show an example of ClinVar somatic data submission interface. " width="1108" height="630" srcset="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/02/ClinVar_Screenshot-1.png?w=1200&ssl=1 1200w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/02/ClinVar_Screenshot-1.png?resize=300%2C171&ssl=1 300w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/02/ClinVar_Screenshot-1.png?resize=1024%2C582&ssl=1 1024w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/02/ClinVar_Screenshot-1.png?resize=150%2C85&ssl=1 150w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/02/ClinVar_Screenshot-1.png?resize=768%2C436&ssl=1 768w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/02/ClinVar_Screenshot-1.png?resize=270%2C153&ssl=1 270w" sizes="auto, (max-width: 1108px) 100vw, 1108px" layout="intrinsic" disable-inline-width="" i-amphtml-layout="intrinsic"><i-amphtml-sizer slot="i-amphtml-svc" class="i-amphtml-sizer"><img alt="" aria-hidden="true" class="i-amphtml-intrinsic-sizer" role="presentation" src="data:image/svg+xml;base64,PHN2ZyBoZWlnaHQ9IjYzMCIgd2lkdGg9IjExMDgiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyIgdmVyc2lvbj0iMS4xIi8+"></i-amphtml-sizer><noscript><img loading="lazy" decoding="async" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/02/ClinVar_Screenshot-1.png?resize=1108%2C630&ssl=1" alt="Table to show an example of ClinVar somatic data submission interface. " width="1108" height="630" srcset="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/02/ClinVar_Screenshot-1.png?w=1200&ssl=1 1200w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/02/ClinVar_Screenshot-1.png?resize=300%2C171&ssl=1 300w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/02/ClinVar_Screenshot-1.png?resize=1024%2C582&ssl=1 1024w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/02/ClinVar_Screenshot-1.png?resize=150%2C85&ssl=1 150w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/02/ClinVar_Screenshot-1.png?resize=768%2C436&ssl=1 768w, https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2024/02/ClinVar_Screenshot-1.png?resize=270%2C153&ssl=1 270w" sizes="auto, (max-width: 1108px) 100vw, 1108px"></noscript></amp-img></p>
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<p><em>Example of somatic submissions for a <a href="https://www.ncbi.nlm.nih.gov/clinvar/variation/13961/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=clinvar-submit-somatic-data-20240229">B-Raf proto oncogene</a> variant from colorectal cancer and melanoma tumors.</em></p>
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<p><span data-contrast="auto">Variants may be classified for clinical impact as in the </span><a href="https://pubmed.ncbi.nlm.nih.gov/27993330/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=clinvar-submit-somatic-data-20240229"><span data-contrast="none">AMP/ASCO/CAP guidelines</span></a><span data-contrast="auto"> and for oncogenicity as in the </span><a href="https://pubmed.ncbi.nlm.nih.gov/36063163/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=clinvar-submit-somatic-data-20240229"><span data-contrast="none">ClinGen/CGC/VICC recommendation</span></a>.<span data-contrast="auto"> </span><span data-ccp-props='{"134233117":true,"134233118":true,"201341983":0,"335559740":240}'> </span></p>
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<p><b><span data-contrast="auto">Important Note:</span></b><span data-contrast="auto"> Both the Submission API and the Single Submission Wizard will also be updated soon to support somatic variants.</span><span data-ccp-props='{"134233117":true,"134233118":true,"201341983":0,"335559740":240}'> </span></p>
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<h5 aria-level="5">Stay up to date</h5>
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<p><span data-contrast="auto">Follow us on social </span><a href="https://twitter.com/ncbi"><span data-contrast="auto">@NCBI</span></a><span data-contrast="auto"> and </span><a href="https://public.govdelivery.com/accounts/USNLMOCPL/subscriber/new?topic_id=USNLMOCPL_52"><span data-contrast="auto">join our mailing list</span></a><span data-contrast="auto"> to keep up to date with ClinVar and other NCBI news.</span><span data-ccp-props='{"134233117":true,"134233118":true,"201341983":0,"335559740":240}'> </span></p>
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<h5 aria-level="5">Questions?</h5>
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<p><span data-contrast="auto">If you have questions or would like to provide feedback, please reach out to us at </span><a href="mailto:clinvar@ncbi.nlm.nih.gov"><span data-contrast="auto">clinvar@ncbi.nlm.nih.gov</span></a><span data-contrast="auto">.</span><span data-ccp-props='{"134233117":true,"134233118":true,"201341983":0,"335559740":240}'> </span></p>
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