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</style><p>This two-day virtual workshop hosted by <a href="https://www.ncbi.nlm.nih.gov/books/NBK53196/" title="NCATS Assay Guidance Manual (AGM)">NCATS Assay Guidance Manual (AGM)</a> covered a broad range of critical concepts underlying assay development and implementation for high-throughput screening and lead discovery projects. This workshop was designed to disseminate best practices for the development and implementation of robust assay methods. It is particularly relevant for researchers developing molecular probes or clinical candidates. Many of the workshop instructors have 20 to 30 years of experience in the field of drug discovery and share information not readily found in a classroom or published material outside of the AGM. This workshop also covered emerging technologies and modalities in drug discovery, including the use of stem cells, antibody therapeutics, DNA-encoded libraries, and advances in COVID-19 therapeutics.</p><h2>Goals and Objectives</h2><p>The goal of the AGM workshop series is to help participants design and implement robust assays in early translation research by providing them a broad, practical perspective on assay development and data analysis. Our aim is to help participants improve their research projects involving drug discovery and know where to find further information; identify reagents, methods and instrumentation that are well suited to robust assays; and develop robust assays and the required counter and secondary assays for targets of interest. The workshops also provide participants with broad overviews and practical perspectives on new and emerging modalities in drug discovery.</p><p><a class="pdf" href="/sites/default/files/AGM_Workshop_Agenda_Nov_18-19_508.pdf" title="View the agenda">View the agenda</a> (PDF - 267KB)</p><hr><h2 align="center">Day 1: Nov. 18, 2020</h2><!-- <div class="row card" style="margin-left:0;margin-right:0;">
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<strong>Christopher P. Austin, M.D.</strong> <br>
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Director <br>
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In his welcome address, Dr. Austin introduces the audience to NCATS, its mission to conduct and disseminate translational science, and to the Assay Guidance Manual (AGM). Dr. Austin also highlights the upcoming events on the AGM calendar.
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<hr> --><div class="row video-gallery "><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=azYGbvMZAPo&list=PLtOMdJ_3bSnz-zxODIJzK0YjjNAL9l2dF&index=1&rel=0"></iframe></div><div class="card-body"><h3>Welcome to the AGM Workshop</h3><p><strong>Christopher P. Austin, M.D.</strong> <br>Director <br>National Center for Advancing Translational Sciences (NCATS)</p><p class="card-text">In his welcome address, Dr. Austin introduces the audience to NCATS, its mission to conduct and disseminate translational science, and to the Assay Guidance Manual (AGM). Dr. Austin also highlights the upcoming events on the AGM calendar.</p></div></div></div><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=1zKgErL-pGg&list=PLtOMdJ_3bSnz-zxODIJzK0YjjNAL9l2dF&index=2&rel=0"></iframe></div><div class="card-body"><h3>Robust or Go Bust: An Introduction to the Assay Guidance Manual</h3><p style="margin-bottom:0;"><strong>Sarine Markossian, Ph.D.</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Editor-in-Chief, Assay Guidance Manual (AGM); Lead, AGM Translational Science Resources Program</p><p class="hanging-text">National Center for Advancing Translational Sciences (NCATS)</p><p class="card-text">Dr. Markossian introduces the audience to assays and their importance in the drug discovery pipeline, and to the Assay Guidance Manual (AGM) program including the e-book and the workshops. Dr. Markossian also highlights the objectives and goals of the workshop.</p></div></div></div><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=stM5LZDTXQE&list=PLtOMdJ_3bSnz-zxODIJzK0YjjNAL9l2dF&index=3&rel=0"></iframe></div><div class="card-body"><h3>Target Qualification Strategies: Functional Genomics for Target ID and Validation</h3><p style="margin-bottom:0;"><strong>Yueming Wang Ph.D.</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Principal Scientist, Primary Pharmacology Group, Medicine Design</p><p class="hanging-text">Pfizer Inc.</p><p class="card-text">Dr. Wang discusses the importance of improving the quality of target selection and details strategies to achieve that goal. He also takes a deep dive into the importance of functional genomics for target ID and validation.</p></div></div></div><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=p1JrTJ1xafc&list=PLtOMdJ_3bSnz-zxODIJzK0YjjNAL9l2dF&index=4&rel=0"></iframe></div><div class="card-body"><h3>Strategies for Assay Selection and for the Development of Robust Biochemical Assays</h3><p style="margin-bottom:0;"><strong>Nathan P. Coussens, Ph.D.</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Director, Molecular Pharmacology Laboratories</p><p class="hanging-text">Frederick National Laboratory for Cancer Research</p><p class="card-text">Dr. Coussens discusses strategies for choosing the right assay for HTS. Dr. Coussens also expands on biochemical assays for enzymes and for molecular interactions.</p></div></div></div><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=EojUncYjLOY&list=PLtOMdJ_3bSnz-zxODIJzK0YjjNAL9l2dF&index=5&rel=0"></iframe></div><div class="card-body"><h3>Treating Cells as Reagents to Design Reproducible Assays</h3><p style="margin-bottom:0;"><strong>Terry Riss, Ph.D.</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Senior Product Manager, Cell Health</p><p class="hanging-text">Promega Corporation</p><p class="card-text">Dr. Riss provides strategies to help design reproducible cell-based assays. He also addresses the major causes of variability in cell-based assays and provides avenues for establishing SOPs for consistent handling of cells.</p></div></div></div><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=L82_IpGfC88&list=PLtOMdJ_3bSnz-zxODIJzK0YjjNAL9l2dF&index=6&rel=0"></iframe></div><div class="card-body"><h3>High Content Imaging Applications: Best Practices and Approaches to Consider</h3><p style="margin-bottom:0;"><strong>Joe Trask</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Product Line Leader & Senior Application Scientist, Cellular Imaging and Analysis</p><p class="hanging-text">PerkinElmer</p><p class="card-text">Mr. Trask introduces the audience to all of the current and upcoming AGM high-content screening (HCS) chapters. This talk also covers an overview of a typical HCS Workflow including its bottlenecks, 3D HCS imaging considerations and an introduction to cell painting.</p></div></div></div><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=x-3lCxKCzvs&list=PLtOMdJ_3bSnz-zxODIJzK0YjjNAL9l2dF&index=7&rel=0"></iframe></div><div class="card-body"><h3>Biophysical Approaches to Small Molecule Discovery and Validation</h3><p style="margin-bottom:0;"><strong>Michelle Arkin, Ph.D.</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Professor, Pharmaceutical Chemistry; Co-Director, Small Molecule Discovery Center</p><p class="hanging-text">University of California, San Francisco</p><p class="card-text">Dr. Arkin describes the role of biophysical methods in drug discovery. Dr. Arkin first provides an overview of commonly used methodologies, and then describes fragment-based discovery as an application of biophysical methods in screening.</p></div></div></div><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=qLXifOzGfuw&list=PLtOMdJ_3bSnz-zxODIJzK0YjjNAL9l2dF&index=8&rel=0"></iframe></div><div class="card-body"><h3>Compound-mediated Interferences in Homogeneous Proximity Assays</h3><p style="margin-bottom:0;"><strong>Jayme L. Dahlin, M.D., Ph.D., FASCP</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Preclinical Medical Director, A Specialized Platform for Innovative Research Exploration (ASPIRE)</p><p class="hanging-text">National Center for Advancing Translational Sciences (NCATS)</p><p class="card-text">Dr. Dahlin provides a background on homogeneous proximity assays and discusses several compound interference mechanisms in these assays. Dr. Dahlin also provides strategies to identify and mitigate compound interferences.</p></div></div></div><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=oIuWMolUE8Q&list=PLtOMdJ_3bSnz-zxODIJzK0YjjNAL9l2dF&index=9&rel=0"></iframe></div><div class="card-body"><h3>In Vitro Toxicological Testing using a qHTS Platform</h3><p style="margin-bottom:0;"><strong>Menghang Xia, Ph.D.</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Group leader, Systems Toxicology, Division of Preclinical Innovation</p><p class="hanging-text">National Center for Advancing Translational Sciences (NCATS)</p><p class="card-text">Dr. Xia introduces the audience to the Tox21 program and further discusses the selection and design of assays used in this program. She then presents a case study for a mitochondrial membrane potential assay as an example of an application of qHTS in toxicology.</p></div></div></div><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=bgwG6bGv1YU&list=PLtOMdJ_3bSnz-zxODIJzK0YjjNAL9l2dF&index=10&rel=0"></iframe></div><div class="card-body"><h3>Lead Selection and Optimization by Medicinal Chemistry</h3><p style="margin-bottom:0;"><strong>Samarjit Patnaik, Ph.D.</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Group Leader, Chemistry, Early Translation Branch, Division of Preclinical Innovation</p><p class="hanging-text">National Center for Advancing Translational Sciences (NCATS)</p><p class="card-text">Dr. Patnaik emphasizes the importance of assay development to medicinal chemistry. He discusses multiple case studies where a change in the assay platform or conditions led to the discovery of unexpected activities of compounds.</p></div></div></div><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=qUEkVJqeg0I&list=PLtOMdJ_3bSnz-zxODIJzK0YjjNAL9l2dF&index=11&rel=0"></iframe></div><div class="card-body"><h3>In Vitro Assessment of ADME Properties of Lead Compounds</h3><p style="margin-bottom:0;"><strong>Xin Xu, Ph.D.</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Senior scientist and the director of pharmacokinetics (PK), Therapeutics Development Branch, Division of Preclinical Innovation</p><p class="hanging-text">National Center for Advancing Translational Sciences (NCATS)</p><p class="card-text">Dr. Xu describes the importance of ADME/PK concepts in drug discovery and development. She also describes the development of in vitro assays to address key ADME issues, and introduces common ADME assays used in drug discovery and development.</p></div></div></div></div><hr><h2 align="center">Day 2: Nov. 19, 2020</h2><div class="row video-gallery "><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=xRD01yMG27s&list=PLtOMdJ_3bSnyRiCprhUSn_8wV3rjQ_Y0F&index=1"></iframe></div><div class="card-body"><h3>Basic Assay Statistics, Data Analysis & Rules of Thumb (ROT)</h3><p style="margin-bottom:0;"><strong>Thomas “TC” D.Y. Chung, Ph.D.</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Director, Translational Outreach Programs</p><p class="hanging-text">Sanford Burnham Prebys Medical Discovery Institute</p><p class="card-text">Dr. Chung introduces basic statistical concepts for proper HTS data analysis and validation. Dr. Chung then describes the Z-factor (Z’) as a simple parameter that summarizes an assay’s robustness.</p></div></div></div><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=9J9CNnVKSVw&list=PLtOMdJ_3bSnyRiCprhUSn_8wV3rjQ_Y0F&index=2"></iframe></div><div class="card-body"><h3>Reproducibility Assessment of In Vitro Screening Results</h3><p style="margin-bottom:0;"><strong>Viswanath Devanarayan, Ph.D., FAAPS</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Senior Statistics Director</p><p class="hanging-text">GlaxoSmithKline</p><p class="card-text">Dr. Devanarayan introduces minimum significant ratio (MSR) as a metric for evaluating the reproducibility of potency results from dose-response screening assays. He then discusses how MSR is calculated and describes different ways of estimating MSR.</p></div></div></div><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=TmdK65zf3Mo&list=PLtOMdJ_3bSnyRiCprhUSn_8wV3rjQ_Y0F&index=3"></iframe></div><div class="card-body"><h3>Assay Operations: Keeping your Assays Robust and Reproducible</h3><p style="margin-bottom:0;"><strong>Jeffrey R. Weidner, Ph.D.</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Founder</p><p class="hanging-text">QualSci Consulting, LLC</p><p class="card-text">Dr. Weidner introduces and defines key statistical concepts for assay robustness and reproducibility. He then introduces the audience to Statistical Process Control (SPC) which applies statistical methods to optimize reproducibility, reliability and quality.</p></div></div></div><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=3cyba6TPtNI&list=PLtOMdJ_3bSnyRiCprhUSn_8wV3rjQ_Y0F&index=4"></iframe></div><div class="card-body"><h3>Kinetics of Target Binding: Impact on Drug Activity from Bench to Bedside</h3><p style="margin-bottom:0;"><strong>Sam Hoare, Ph.D.</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Founder</p><p class="hanging-text">Pharmechanics, LLC</p><p class="card-text">Dr. Hoare introduces basic concepts and principles in binding kinetics and its impact on drug measurements. Dr. Hoare then describes methodologies for measuring binding kinetics and highlights when to apply kinetics in drug discovery.</p></div></div></div><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=ynCPoy0n6ro&list=PLtOMdJ_3bSnyRiCprhUSn_8wV3rjQ_Y0F&index=5"></iframe></div><div class="card-body"><h3>Why You Want to Use Stem Cells for Drug Discovery</h3><p style="margin-bottom:0;"><strong>Marcie Glicksman, Ph.D.</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Head of Biology</p><p class="hanging-text">EnClear Therapies</p><p class="card-text">Dr. Glicksman emphasizes the importance of using stem cells in drug discovery campaigns and describes different stem cell technologies utilized in drug discovery. Dr. Glicksman also provides examples and case studies where stem cells were used in the drug discovery process as well as for therapy.</p></div></div></div><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=ao25JYg8leg&list=PLtOMdJ_3bSnyRiCprhUSn_8wV3rjQ_Y0F&index=6"></iframe></div><div class="card-body"><h3>Toward the Efficient Discovery of Actionable Chemical Matter from DNA-encoded Libraries</h3><p style="margin-bottom:0;"><strong>Timothy L. Foley, Ph.D.</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Pharmacology & DEL Selection Biology Lab Head, Primary Pharmacology Group</p><p class="hanging-text">Pfizer Inc.</p><p class="card-text">Dr. Foley introduces DNA-encoded chemical libraries (DEL) and describes how they are used for lead discovery. Dr. Foley then addresses several topics including reproducibility in DEL screens, hit selection and conformation, as well as some challenges in these processes.</p></div></div></div><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=gchPVv33ExM&list=PLtOMdJ_3bSnyRiCprhUSn_8wV3rjQ_Y0F&index=7"></iframe></div><div class="card-body"><h3>Antibody Binding Sites as Therapeutics: From scFv to V<sub>H</sub>H and V<sub>NAR</sub></h3><p style="margin-bottom:0;"><strong>Mitchell Ho, Ph.D.</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Deputy Chief, Laboratory of Molecular Biology</p><p class="hanging-text">National Cancer Institute (NCI), NIH</p><p class="card-text">Dr. Ho describes different approaches for therapeutic antibody discovery. He then introduces the concept of antibody binding site as therapeutics and takes a deep dive into the utility of single-chain variable fragment (scFv) and single domain antibodies in therapeutics.</p></div></div></div><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=c5aigqGITpk&list=PLtOMdJ_3bSnyRiCprhUSn_8wV3rjQ_Y0F&index=8"></iframe><!--<img class="video-placeholder-image" src="/sites/default/files/Video_coming_soon-agm_placeholder_-bottom_border_800x450.png" />--></div><div class="card-body"><h3>COVID19: The NCATS Experience</h3><p style="margin-bottom:0;"><strong>Matthew D. Hall, Ph.D.</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Director, Early Translation Branch, Division of Preclinical Innovation</p><p class="hanging-text">National Center for Advancing Translational Sciences (NCATS)</p><p class="card-text">Dr. Hall describes activities conducted by NCATS to address COVID-19 including SARS-CoV-2 assay development and screening, as well as the launch of an open data portal to share COVID-19 drug repurposing data in real time.</p></div></div></div><div class="col-md-6 col-xl-4 d-flex"><div class="card card-wrapper shadow-sm flex-fill"><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed?v=52a43qX1Zi8&list=PLtOMdJ_3bSnyRiCprhUSn_8wV3rjQ_Y0F&index=9"></iframe><!-- <img class="video-placeholder-image" src="/sites/default/files/Video_coming_soon-agm_placeholder_-bottom_border_800x450.png" /> --></div><div class="card-body"><h3>Closing Remarks</h3><p style="margin-bottom:0;"><strong>Anton Simeonov, Ph.D.</strong></p><p class="hanging-text" style="margin-bottom:0;margin-top:0;">Scientific Director, Division of Preclinical Innovation</p><p class="hanging-text">National Center for Advancing Translational Sciences (NCATS)</p><p class="card-text">In his closing remarks, Dr. Simeonov describes the AGM as a freely available resource for early discovery and emphasizes that the AGM program is becoming a community of followers, practitioners, and disseminators. Dr. Simeonov highlights the future directions and the upcoming events of the AGM.</p></div></div></div></div>
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