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<span>Stem Cell Translation Laboratory (SCTL)</span>
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<h1>Stem Cell Translation Laboratory (SCTL)</h1>
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The SCTL utilizes the latest technology and techniques in stem cell research to investigate innovative methodologies for accelerating the therapeutic development process.
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<h2 class="section-heading">About SCTL</h2>
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</style><div class="contact-box"><h4>Contact</h4><p><a href="mailto:Carlos.Tristan@nih.gov">Carlos Tristan, Ph.D.</a></p><hr><h4>Job Opportunities</h4><p><a href="https://ipsc.ncats.nih.gov/jobs/">View Current Open Positions at the SCTL</a></p></div><p>The progress made in stem cell biology over the past decade has opened many new opportunities for basic and translational scientists worldwide. Induced pluripotent stem cells (iPSCs) are particularly useful because scientists can group them into many specialized cell types to use for research or regenerative medicine applications (e.g., cell and gene therapy).</p><h3>About the Science</h3><p>Scientists produce iPSCs by reprogramming adult cells (e.g., skin cells, blood cells) to an embryonic stem cell–like state, where they have the potential to become any cell type of the human body. iPSC-based therapies are ideal because they use a patient's own cells, preventing such potential complications as rejection by the immune system. In addition, scientists can use iPSCs to produce the large amounts of relevant cells (e.g., nerve cells, liver cells) needed for disease research, tissue engineering, toxicology and regenerative medicine. Major limitations that currently impede the application of iPSCs include the lack of highly reproducible and well-defined procedures required to generate, characterize and differentiate patient-specific iPSCs safely for preclinical and clinical use.</p><h3>About the Lab</h3><p>To establish and move stem cell technologies forward through a more centralized effort, NIH has launched the Stem Cell Translation Laboratory (SCTL) within NCATS. Initially part of the NIH Common Fund's <a href="https://commonfund.nih.gov/stemcells">Regenerative Medicine Program</a>, the goal of the SCTL is to bring iPSC technology closer to clinical applications and drug development. Through the SCTL, NCATS provides researchers across various disciplines and organizations access to innovative protocols and resources to advance the translation of regenerative medicine applications. Through a multidisciplinary collaborative team approach, NCATS' SCTL scientists aim to:</p><ol><li>Establish quality control (QC) standards to define pluripotency and differentiated cell types</li><li>Develop methods to assess heterogeneity and characterize iPSC-derived cells using multi-omics technologies</li><li>Develop standardized methods to produce mature and functional cells meeting the QC standards above</li><li>Discover, validate and disseminate small-molecule reagents to replace expensive recombinant proteins, xenogeneic material and undefined media components in cell differentiation protocols</li></ol>
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<h2 class="section-heading">SCTL News</h2>
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<img loading="lazy" src="/sites/default/files/styles/media_library/public/Singec_Tristan_Nature_Protocols_hPSC_dissociation_image_0.png?itok=v4hcr7Qs" width="220" height="210" alt="Individual stem cells in wells on a plate." />
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<h3 class="title">Better Method for Growing Stem Cells Could Speed Gene-Editing Therapies</h3>
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<p class="m-0"><i>April 7, 2023 - NCATS News</i>
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<ul class="list-pipe">
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<li><i>Stem Cell Translation Laboratory (SCTL)</i></li>
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<p>Scientists have published step-by-step instructions on how to use a four-part cocktail of drugs and compounds to grow stem cells from a single cell.</p>
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<a href="/news-events/news/better-method-for-growing-stem-cells-could-speed-gene-editing-therapies">Read Article</a>
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<h3 class="title">Say Yes Until You Can Say No, Says NCATS’s Ryu</h3>
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<p class="m-0"><i>March 29, 2024 - Grantee/Partner News</i>
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<ul class="list-pipe">
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<li><i>Stem Cell Translation Laboratory (SCTL)</i></li>
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<a href="https://nihrecord.nih.gov/2024/03/29/say-yes-until-you-can-say-no-says-ncats-s-ryu">Read Article</a>
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<h3 class="title">FUJIFILM Wako Chemicals U.S.A. Commercializes CEPT Cocktail for Research-Use iPSC Applications</h3>
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<p class="m-0"><i>April 20, 2023 - Media Coverage</i>
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<ul class="list-pipe">
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<li><i>Stem Cell Translation Laboratory (SCTL)</i></li>
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<div class="usa-card__footer">
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<a href="https://apnews.com/press-release/globe-newswire/stem-cell-research-fujifilm-holdings-corp-globe-newswire-business-137ac3fe958ffcedd5f8d7b80e23a33e">Read Article</a>
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<div class="col-sm-4 mb-4 views-row"><div class="usa-card__container">
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<div class="usa-card__body">
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<h3 class="title">Painkillers That Don’t Kill</h3>
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<p class="m-0"><i>March 14, 2022 - Media Coverage</i>
|
||
</p>
|
||
<ul class="list-pipe">
|
||
<li><i>Stem Cell Translation Laboratory (SCTL)</i></li>
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</ul>
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</div>
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<div class="usa-card__footer">
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<a href="https://nautil.us/painkillers-that-dont-kill-238442/">Read Article</a>
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<div class="text-center button-wrap">
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<button class="buttons btn-1 mt-4"><a href="/news-events/news?program%5B0%5D=stem%20cell%20translation%20laboratory">See More SCTL News</a></button>
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<div class="container news-content Advancing">
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<h2>Virtual Tour of Stem Cell Translation Lab</h2>
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<div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed/zAx6g5zcfXg?si=9ntSzLIe6AihOgZc&rel=0"></iframe></div><p>This video (video length: 5:06) provides an overview of the SCTL lab and how NCATS is applying stem cells in translational science. Read Transcript.</p>
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<h2>Contact Us</h2>
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<div class="paragraph paragraph--type--single-contact paragraph--view-mode--default">
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<p>If you are an NIH Investigator, you can submit your proposal to the Functional Genomics Lab. </p><p>Connect with Carlos Tristan, Ph.D., to get started.</p><p> </p>
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<button class="buttons btn-1 mt-4"><a href="mailto:Carlos.tristan@nih.gov">Contact Us</a></button>
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<h2 class="section-heading">Our Team</h2>
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<p>The SCTL team is composed of talented researchers who bring their diverse expertise together to advance stem cell research.</p>
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<img class="staff-image" src="/sites/default/files/styles/staff/public/staff/deng_tao_900x1000px.jpg?itok=zDSEQQax" alt="Portrait of Tao Deng" />
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<div class="col-sm-8 staff-text">
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<h6 class="title"><a href="/about/our-staff/dengt">Tao Deng, Ph.D.</a></h6>
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<p class="position">Research Scientist</p>
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<p class="branch">
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</p>
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<p class="mb-1">Division of Preclinical Innovation </p>
|
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<!--<p class="division"></p>-->
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<p class="email"><a href="mailto:dengt@mail.nih.gov">
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dengt@mail.nih.gov
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<img class="staff-image" src="/sites/default/files/styles/staff/public/staff/jovanovic_900x1000px_0.jpg?itok=PKapD0yx" alt="Portrait of Vukasin Jovanovic" />
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<h6 class="title"><a href="/about/our-staff/jovanovicv2">Vukasin Jovanovic, Ph.D.</a></h6>
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<p class="position">Research Fellow</p>
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<p class="mb-1">Division of Preclinical Innovation </p>
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<p class="email"><a href="mailto:vukasin.jovanovic@nih.gov">
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vukasin.jovanovic@nih.gov
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<img class="staff-image" src="/sites/default/files/styles/staff/public/staff/Seungmi-Ryu_900x1000px.jpg?itok=VYw9zwZT" alt="Seungmi Ryu, Ph.D." />
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<h6 class="title"><a href="/about/our-staff/ryus4">Seungmi Ryu, Ph.D.</a></h6>
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<p class="branch">
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Chemical Genomics Branch
|
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<p class="mb-1">Division of Preclinical Innovation </p>
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<p class="email"><a href="mailto:seungmi.ryu@nih.gov">
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seungmi.ryu@nih.gov
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<img class="staff-image" src="/sites/default/files/styles/staff/public/staff/tristan_carlos_900x1000px.jpg?itok=ApU-rhZn" alt="Portrait of Carlos A. Tristan" />
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<h6 class="title"><a href="/about/our-staff/tristanc">Carlos A. Tristan, Ph.D., M.S.</a></h6>
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<p class="position">Director</p>
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<p class="email"><a href="mailto:carlos.tristan@nih.gov">
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||
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carlos.tristan@nih.gov
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<div class="container news-content Advancing">
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<h2 class="section-heading">Related Research</h2>
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<div class="row mb-4 three-pic-cards">
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<div class="col-xl-4 ps-xl-3 mb-4">
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<img src="/sites/default/files/2023-09/3D%20Bioprinting%20Card%20Related%20Research_746x370.png" class="img-fluid">
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</div>
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||
<div class="col-xl-12 col-lg-6">
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||
<div class="card-body px-0 pt-0">
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<h3 class="">3-D Tissue Bioprinting</h3>
|
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<p class="py-xl-0 py-lg-4 py-md-4 py-sm-4 py-2">
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||
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||
<p>Our scientists are creating and using 3-D printing techniques to make tissue models that closely resemble the complex structure and organization of our cells.</p>
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</p>
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<div class="card-footer bg-white border-0 p-0">
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<a href="/research/research-activities/bioprinting">Learn More</a>
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<div class="col-xl-12 col-lg-6">
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<img src="/sites/default/files/2023-09/PaVe-GT%20Related%20Research%20card_746x370_0.png" class="img-fluid">
|
||
</div>
|
||
<div class="col-xl-12 col-lg-6">
|
||
<div class="card-body px-0 pt-0">
|
||
<h3 class="">Platform Vector Gene Therapy (PaVe-GT)</h3>
|
||
<p class="py-xl-0 py-lg-4 py-md-4 py-sm-4 py-2">
|
||
|
||
<p>Our pilot project is testing the feasibility of increasing the efficiency of gene therapy clinical trials by using the same gene delivery system and manufacturing methods for multiple gene therapies.</p>
|
||
|
||
</p>
|
||
</div>
|
||
<div class="card-footer bg-white border-0 p-0">
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<a href="/research/research-activities/pave-gt">Learn More</a>
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||
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</div>
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<div class="col-xl-4 ps-xl-3 mb-4">
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<div class="col-xl-12 col-lg-6">
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||
<img src="/sites/default/files/2023-09/ADST%20Related%20Research%20card_746x370.png" class="img-fluid">
|
||
</div>
|
||
<div class="col-xl-12 col-lg-6">
|
||
<div class="card-body px-0 pt-0">
|
||
<h3 class="">Assay Development and Screening Technology (ADST)</h3>
|
||
<p class="py-xl-0 py-lg-4 py-md-4 py-sm-4 py-2">
|
||
|
||
<p>Our scientists explore and develop new ways to quickly test and screen potential drug candidates, often in collaboration with disease foundations.</p>
|
||
|
||
</p>
|
||
</div>
|
||
<div class="card-footer bg-white border-0 p-0">
|
||
<a href="/research/research-activities/assay-development-and-screening-technology">Learn More</a>
|
||
</div>
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||
</div>
|
||
|
||
</div>
|
||
</div>
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</div>
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</article>
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ul#superfish-navigation li { line-height:1.25; }
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