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<h1>3-D Tissue Bioprinting Operational Model</h1>
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Our projects are partnerships with members of the broad biomedical community, who provide expertise on disease physiology, access to patient-derived induced pluripotent stem cells and primary cells, and access to disease animal models. In turn, we provide expertise in tissue engineering, assay development and drug screening.
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<div class="sidebar-right"><div class="contact-box"><h4>Contact</h4><p><a class="mailto:ferrerm@mail.nih.gov" href="mailto:ferrerm@mail.nih.gov">Marc Ferrer, Ph.D.</a></p></div><div class="image-box"><p><img src="/sites/default/files/3d-Histology_900x600.jpg" alt="Histology is the gold standard to determine the architecture of tissues. These panels showing histological images of 3-D Bioprinted skin (top row) and native skin (bottom row) staining for different markers relevant to skin cells and extracellular matrix composition." width="900" height="600"></p><div class="caption-text"><p>Histology is the gold standard to determine the architecture of tissues. These panels showing histological images of 3-D Bioprinted skin (top row) and native skin (bottom row) staining for different markers relevant to skin cells and extracellular matrix composition. (<em>Paige Derr and Kristy Derr, NCATS</em>)</p></div></div></div><p>We work collaboratively with NIH intramural and extramural investigators and clinicians, regulatory agencies, biopharma industry groups and technology providers to advance, demonstrate and disseminate the development, application and use of 3-D tissue models for advancing therapeutics discovery and development. </p><h3>History of the Program</h3><p><strong>2013: </strong>A research collaboration agreement was signed between NIH — including NCATS and the National Eye Institute (NEI) — and Organovo, a company dedicated to pushing through the development of new therapies through the design and creation of functional human tissues using proprietary 3-D bioprinting technologies. As part of the partnership, NCATS <a href="https://ir.organovo.com/news-releases/news-release-details/organovo-announces-collaboration-national-institutes-health?c=254194&p=irol-newsArticle&ID=2129449">installed an Organovo NovoGen MMX Bioprinter®</a> to develop 3-D bioprinted retinal (jointly with NEI) and skin tissue.</p><p><strong>2016:</strong> The 3-D Tissue Bioprinting program at NCATS received funding through the <a href="/about/advisory-committees/can">Cures Acceleration Network</a>, which allowed the program to expand its bioprinting technical capabilities, create a histology core, and expand its microscopy imaging capabilities. It also enabled requests for applications (RFAs) to fund extramural labs to collaborate with NCATS to implement drug screens with 3-D bioprinted tissue models.</p><p><strong>2017:</strong> NCATS published an RFA, RFA-TR-17-007, titled NCATS Pilot Program for Collaborative Drug Discovery Research Using Bioprinted Skin Tissue (U18). Two teams at Columbia University (Angela Christiano, Ph.D.) and Rockefeller University/New York University (Dan Gareau, Ph.D.) received funding through this opportunity.</p><p><strong>2018: </strong>The 3-D Tissue Bioprinting Laboratory (3DTBL) was formally established in the Division of Preclinical development at NCATS.</p><p><strong>2018: </strong>The 3DTBL received funding from NIH’s Helping to End Addiction Long-term (HEAL) initiative to develop biofabricated 3-D tissue models of nociception, opioid use disorder and overdose for drug screening.</p><p><strong>2019: </strong>NCATS published an RFA, RFA-TR-19-020, titled Drug Screening With Biofabricated 3-D Skin Disease Tissue Models (U18). Two teams at Columbia University (Angela Christiano, Ph.D.) and University of Washington (Jia Zhu, Ph.D.) received funding through this opportunity.</p><p><strong>2020: </strong>The 3DTBL received funding from the Coronavirus Aid, Relief, and Economic Security (CARES) Act (2020) to develop biofabricated 3-D tissue models for COVID-19 drug screening.</p><p><strong>2021: </strong>NCATS published an RFA, RFA-TR-21-015, titled Intramural-Extramural Collaboration for Drug Screening with Biofabricated 3-D Disease Tissue Models (UH2/UH3). Two teams at the University of Pittsburgh (Dr. Mark Miedel) and University of Texas Medical Branch Galveston/Texas A&M (Drs. Ram Menon and Arum Han) received funding through this opportunity.</p>
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